Pub Date : 2019-03-01DOI: 10.46958/rcv.2019.xxiv.n.139.p.54-65
Luanna F. Fasanelo Gomes, Stefano C. Filippo Hagen
Ultrasonography is not frequently used in the evaluation of the musculoskeletal system of dogs. During the last three decades this imaging technique has been shown to be valuable in the diagnosis and monitoring the musculoskeletal disorders of human patients. Ultrasonography allows recognitions of different anatomical joint structures and enables detection of lesions in tendons, ligaments, joint capsule, cartilage, meniscus and bone surfaces. The diagnostic value of the technique is highly operator-dependent, and can be influenced by the difficult to access to some anatomical structures. In spite of its limitations, the availability and low cost of the ultrasonography can make it an important tool in the assessment of musculoskeletal disorders in dogs.
{"title":"Ultrasonography diagnosis of joint diseases in dogs – review","authors":"Luanna F. Fasanelo Gomes, Stefano C. Filippo Hagen","doi":"10.46958/rcv.2019.xxiv.n.139.p.54-65","DOIUrl":"https://doi.org/10.46958/rcv.2019.xxiv.n.139.p.54-65","url":null,"abstract":"Ultrasonography is not frequently used in the evaluation of the musculoskeletal system of dogs. During the last three decades this imaging technique has been shown to be valuable in the diagnosis and monitoring the musculoskeletal disorders of human patients. Ultrasonography allows recognitions of different anatomical joint structures and enables detection of lesions in tendons, ligaments, joint capsule, cartilage, meniscus and bone surfaces. The diagnostic value of the technique is highly operator-dependent, and can be influenced by the difficult to access to some anatomical structures. In spite of its limitations, the availability and low cost of the ultrasonography can make it an important tool in the assessment of musculoskeletal disorders in dogs.","PeriodicalId":10255,"journal":{"name":"Clínica Veterinária","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75340217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.46958/rcv.2019.xxiv.n.139.p.36-52
V. Nowosh, Cristina de O. M. S. Gomes
Liquid biopsy is a diagnostic and prognostic tool already reported in several studies with human oncologic patients, and shows potential for application in veterinary oncology. However, liquid biopsy is not a widely known technique in veterinary medicine, and related research is sparse. Liquid biopsy is based on the analysis of blood samples for detection of various tumoral products in circulation. It is a non-invasive technique, and provides results in real time. Information obtained from liquid biopsies can complement the information obtained from the analysis of tissue biopsy. In this review of literature, we present the background principles of liquid biopsy, its methodology, and the tumoral products that can currently be detected with this tool. In addition to circulating tumor cells, liquid biopsies allow detection of nucleic acids, including tumor DNA, micro-RNA, messenger RNA and exosomes. We present the value of liquid biopsy as a diagnostic and prognostic tool, its predictive value in tumor progression and treatment success, and usefulness to assist treatment choice. We discuss its limitations, and the challenges to implement its use in a large scale.
{"title":"Liquid biopsy and its applications in veterinary medicine – a review","authors":"V. Nowosh, Cristina de O. M. S. Gomes","doi":"10.46958/rcv.2019.xxiv.n.139.p.36-52","DOIUrl":"https://doi.org/10.46958/rcv.2019.xxiv.n.139.p.36-52","url":null,"abstract":"Liquid biopsy is a diagnostic and prognostic tool already reported in several studies with human oncologic patients, and shows potential for application in veterinary oncology. However, liquid biopsy is not a widely known technique in veterinary medicine, and related research is sparse. Liquid biopsy is based on the analysis of blood samples for detection of various tumoral products in circulation. It is a non-invasive technique, and provides results in real time. Information obtained from liquid biopsies can complement the information obtained from the analysis of tissue biopsy. In this review of literature, we present the background principles of liquid biopsy, its methodology, and the tumoral products that can currently be detected with this tool. In addition to circulating tumor cells, liquid biopsies allow detection of nucleic acids, including tumor DNA, micro-RNA, messenger RNA and exosomes. We present the value of liquid biopsy as a diagnostic and prognostic tool, its predictive value in tumor progression and treatment success, and usefulness to assist treatment choice. We discuss its limitations, and the challenges to implement its use in a large scale.","PeriodicalId":10255,"journal":{"name":"Clínica Veterinária","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86886398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.46958/rcv.2019.xxiv.n.138.p.34-40
Laís Limeira Rodrigues, Leonardo Pereira Mesquita, Denis Alberto Zanatto, P. Maiorka
In dogs and cats, Horner's syndrome is characterized by a group of clinical signs arising from an ipsilateral dysfunction of sympathetic innervation of the eye and its appendages. These signs include ptosis, miosis, anisocoria, prolapse of the third eyelid, and enophtalmos. Lesions that may affect directly or indirectly the sympathetic innervation of the eye, such as trauma, neoplasms, iatrogenic lesions, otitis, encephalitis, among others, can induce HS. The aim of the present study was to review the anatomical and physiological characteristics of sympathetic innervation for the ocular globe, with emphasis on the description of the peculiarities of HS, including its etiology, clinical signs, diagnostic tools, as well as its possible treatments and prognosis.
{"title":"Horner’s syndrome in dogs and cats – a review","authors":"Laís Limeira Rodrigues, Leonardo Pereira Mesquita, Denis Alberto Zanatto, P. Maiorka","doi":"10.46958/rcv.2019.xxiv.n.138.p.34-40","DOIUrl":"https://doi.org/10.46958/rcv.2019.xxiv.n.138.p.34-40","url":null,"abstract":"In dogs and cats, Horner's syndrome is characterized by a group of clinical signs arising from an ipsilateral dysfunction of sympathetic innervation of the eye and its appendages. These signs include ptosis, miosis, anisocoria, prolapse of the third eyelid, and enophtalmos. Lesions that may affect directly or indirectly the sympathetic innervation of the eye, such as trauma, neoplasms, iatrogenic lesions, otitis, encephalitis, among others, can induce HS. The aim of the present study was to review the anatomical and physiological characteristics of sympathetic innervation for the ocular globe, with emphasis on the description of the peculiarities of HS, including its etiology, clinical signs, diagnostic tools, as well as its possible treatments and prognosis.","PeriodicalId":10255,"journal":{"name":"Clínica Veterinária","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88749652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.46958/RCV.2019.XXIV.N.138.P.58-71
Sérgio Diego Passos Costa, B. M. Araújo, N. L. Rocha, Thays G. Rodrigues dos Santos, Jamilly N. R. Costa, N. M. A. Neto, M. C. Rodrigues
Intervertebral disc disease (IVDD) is a common disorder, and most frequently affects the spinal cord at thoracolumbar region. Multiple factors are involved in the pathogenesis of the disease, and it has different characteristics in chondrodystrophic and non-chondrodystrophic breeds. Biochemical and molecular changes observed in the degenerate disc are similar independent of the affected breed. Advanced image techniques demonstrate degenerative characteristics different than those reported by Hansen in the 1960s. Based on and in light of these new findings, new treatments for IVDD have been roosed to optimize the recovery of affected dogs. We reviewed the literature related to thoracolumbar intervertebral disc disease in dogs with emphasis on pathogenesis, classification and treatment options.
{"title":"Canine thoracolumbar disc disease: pathogenesis, current classifications and therapeutic options","authors":"Sérgio Diego Passos Costa, B. M. Araújo, N. L. Rocha, Thays G. Rodrigues dos Santos, Jamilly N. R. Costa, N. M. A. Neto, M. C. Rodrigues","doi":"10.46958/RCV.2019.XXIV.N.138.P.58-71","DOIUrl":"https://doi.org/10.46958/RCV.2019.XXIV.N.138.P.58-71","url":null,"abstract":"Intervertebral disc disease (IVDD) is a common disorder, and most frequently affects the spinal cord at thoracolumbar region. Multiple factors are involved in the pathogenesis of the disease, and it has different characteristics in chondrodystrophic and non-chondrodystrophic breeds. Biochemical and molecular changes observed in the degenerate disc are similar independent of the affected breed. Advanced image techniques demonstrate degenerative characteristics different than those reported by Hansen in the 1960s. Based on and in light of these new findings, new treatments for IVDD have been roosed to optimize the recovery of affected dogs. We reviewed the literature related to thoracolumbar intervertebral disc disease in dogs with emphasis on pathogenesis, classification and treatment options.","PeriodicalId":10255,"journal":{"name":"Clínica Veterinária","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73764291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.46958/rcv.2019.xxiv.n.138.p.42-46
Diego Federico Blanco, M. Sclocco, J. Troiano
Ovarian cysts are not funcional fluid-filled structures, which can spontaneously develop in the ovaries during the reproductive cycle, and secrete female hormones in increased amounts, causing irregular reproductive cycles and infertility. We describe the case of a 4 year old, intact female guinea pig presented with anorexia, progressive weight loss and enlarged abdomen. She was fed commercial rodent dry food, fruits and vegetables. An abdominal ultrasonography revealed the presence of ovarian cysts, and an exploratory laparotomy was recommended. The pig was anesthetized with a combination of intramuscular xylazine (1 mg/kg); ketamine (25 mk/kg) and nalbuphine (1 mg/kg) followed by inhalatory anesthesia with 3% isoflurane during induction and 1% for maintenance. Surgical approach was median laparotomy. Bilateral ovariectomy with removal of the ovariany cyst was performed. Postoperative treatment consisted in administration of enrofloxacin 5 mg/kg every 24 hours via SC, feeding of commercial food until sutures were removed, 10 days after surgery.
{"title":"Ovary cysts in a guinea pig (Cavia porcellus) – case report","authors":"Diego Federico Blanco, M. Sclocco, J. Troiano","doi":"10.46958/rcv.2019.xxiv.n.138.p.42-46","DOIUrl":"https://doi.org/10.46958/rcv.2019.xxiv.n.138.p.42-46","url":null,"abstract":"Ovarian cysts are not funcional fluid-filled structures, which can spontaneously develop in the ovaries during the reproductive cycle, and secrete female hormones in increased amounts, causing irregular reproductive cycles and infertility. We describe the case of a 4 year old, intact female guinea pig presented with anorexia, progressive weight loss and enlarged abdomen. She was fed commercial rodent dry food, fruits and vegetables. An abdominal ultrasonography revealed the presence of ovarian cysts, and an exploratory laparotomy was recommended. The pig was anesthetized with a combination of intramuscular xylazine (1 mg/kg); ketamine (25 mk/kg) and nalbuphine (1 mg/kg) followed by inhalatory anesthesia with 3% isoflurane during induction and 1% for maintenance. Surgical approach was median laparotomy. Bilateral ovariectomy with removal of the ovariany cyst was performed. Postoperative treatment consisted in administration of enrofloxacin 5 mg/kg every 24 hours via SC, feeding of commercial food until sutures were removed, 10 days after surgery.","PeriodicalId":10255,"journal":{"name":"Clínica Veterinária","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86321330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.46958/rcv.2019.xxiv.n.138.p.48-56
Carolina T. Cordeiro, Simone T. de O. Stedile, Matheus Barbosa Gomes
The leptospirosis is a disease not yet clearly understood in cats. Cats can produce response with specific antibodies, but data on the clinical disease is lacking. Serological studies show a prevalence of 4.1% to 33.3% of leptospirosis in cats, and several serovars have been described. Recently studies suggest a possible relationship between infection and chronic and acute kidney lesion. Considering that kidney disease is a common occurrence in cats, it's possible that leptospirosis could be an underdiagnosed cause of renal disease in this species. Cats can present lepstospiruria, and could be reservoirs for Leptospira. The exact risk of another mammals contamination by the cats' urine is yet unknown. Future studies focused on disease and treatment of leptospirosis in cats could greatly improve our understanding of the epidemiology of leptospirosis in cats.
{"title":"Leptospira spp. in cats – review","authors":"Carolina T. Cordeiro, Simone T. de O. Stedile, Matheus Barbosa Gomes","doi":"10.46958/rcv.2019.xxiv.n.138.p.48-56","DOIUrl":"https://doi.org/10.46958/rcv.2019.xxiv.n.138.p.48-56","url":null,"abstract":"The leptospirosis is a disease not yet clearly understood in cats. Cats can produce response with specific antibodies, but data on the clinical disease is lacking. Serological studies show a prevalence of 4.1% to 33.3% of leptospirosis in cats, and several serovars have been described. Recently studies suggest a possible relationship between infection and chronic and acute kidney lesion. Considering that kidney disease is a common occurrence in cats, it's possible that leptospirosis could be an underdiagnosed cause of renal disease in this species. Cats can present lepstospiruria, and could be reservoirs for Leptospira. The exact risk of another mammals contamination by the cats' urine is yet unknown. Future studies focused on disease and treatment of leptospirosis in cats could greatly improve our understanding of the epidemiology of leptospirosis in cats.","PeriodicalId":10255,"journal":{"name":"Clínica Veterinária","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83619548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.46958/rcv.2018.xxiii.n.137.p.44-57
V. de Marco, R. Ubukata, Bianca M. Gonçalves, Nilson K. Kage, M. Kahvegian
Pheochromocytoma is a catecholamine secreting tumor that may be difficult to diagnose because clinical signs are not always present due to the episodic secretion of epinephrine and norepinephrine. We report a case of pheochromocytoma in an asymptomatic 9-year-old intact male maltese. The adrenal mass was an incidental finding during an abdominal ultrasonographic exam. Surgical treatment was declined by the owner. Eight months later the animal was presented with neoplastic thrombus in the caudal vena cava, and was submitted to adrenalectomy with venotomy and thrombectomy. The histopathological exam confirmed the diagnosis and surgical treatment of adrenal tumors, including cases of incidental finding in asymptomatic animals is emphasized here. Currently, five years after surgery, the dog is stable, healthy and without recurrence or evidences of tumor metastasis.
{"title":"Malignant pheochromocytoma in a dog – case report","authors":"V. de Marco, R. Ubukata, Bianca M. Gonçalves, Nilson K. Kage, M. Kahvegian","doi":"10.46958/rcv.2018.xxiii.n.137.p.44-57","DOIUrl":"https://doi.org/10.46958/rcv.2018.xxiii.n.137.p.44-57","url":null,"abstract":"Pheochromocytoma is a catecholamine secreting tumor that may be difficult to diagnose because clinical signs are not always present due to the episodic secretion of epinephrine and norepinephrine. We report a case of pheochromocytoma in an asymptomatic 9-year-old intact male maltese. The adrenal mass was an incidental finding during an abdominal ultrasonographic exam. Surgical treatment was declined by the owner. Eight months later the animal was presented with neoplastic thrombus in the caudal vena cava, and was submitted to adrenalectomy with venotomy and thrombectomy. The histopathological exam confirmed the diagnosis and surgical treatment of adrenal tumors, including cases of incidental finding in asymptomatic animals is emphasized here. Currently, five years after surgery, the dog is stable, healthy and without recurrence or evidences of tumor metastasis.","PeriodicalId":10255,"journal":{"name":"Clínica Veterinária","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73412577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.46958/rcv.2018.xxiii.n.137.p.58-68
Gustavo Soares Forlani, Risciela Salardi Alves de Brito, J. Salame, Angelita Dos Reis Gomes, Márcia de Oliveira Nobre
Sporotrichosis is a subcutaneous mycosis caused by the fungi of the Sporothrix schencki complex. The disease affects men and animals and is particularly severe in cats. The infection is typically acquired by traumatic inoculation of the fungus through scratches and bites from infected animals. Prognosis is worse in patients with immunodepressive diseases such as FeLV, and when administration of treatment is challenging. We report the therapeutic management of sporotrichosis in a cat seropositive for FeLV. Treatment resulted in regression of lesions and marked improvement of clinical signs.
{"title":"Sporotrichosis in a FeLV seropositive feline – case report","authors":"Gustavo Soares Forlani, Risciela Salardi Alves de Brito, J. Salame, Angelita Dos Reis Gomes, Márcia de Oliveira Nobre","doi":"10.46958/rcv.2018.xxiii.n.137.p.58-68","DOIUrl":"https://doi.org/10.46958/rcv.2018.xxiii.n.137.p.58-68","url":null,"abstract":"Sporotrichosis is a subcutaneous mycosis caused by the fungi of the Sporothrix schencki complex. The disease affects men and animals and is particularly severe in cats. The infection is typically acquired by traumatic inoculation of the fungus through scratches and bites from infected animals. Prognosis is worse in patients with immunodepressive diseases such as FeLV, and when administration of treatment is challenging. We report the therapeutic management of sporotrichosis in a cat seropositive for FeLV. Treatment resulted in regression of lesions and marked improvement of clinical signs.","PeriodicalId":10255,"journal":{"name":"Clínica Veterinária","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81448504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.46958/rcv.2018.xxiii.n.137.p.32-42
R. F. Teixeira, Thais Eleonora Madeira Buti, André Luiz Mota da Costa
Main mortality causes of neotropical primates are trauma and viral, bacterial and parasitic diseases. In all cases of animal death necropsy, histopathology, and complementary exams are essential to determine the cause of death. Between May 2017 and May 2018, 59 cases of death of non-human primates were registered during the Yellow Fever outbreak in the region of Sorocaba, São Paulo, Brazil. Five species of the genera Callithrix, Alouatta and Sapajus were identified. Wildlife and captivity animals were represented. All biological materials collected during necropsies were submitted to Instituto Adolf Lutz (in São Paulo, Brazil) to be tested for the Yellow Fever virus. Documented causes of death included Yellow Fever, unspecified trauma, interspecies and intraspecies aggression, firearm-induced trauma, pneumonia, and carbamate toxicosis.
{"title":"Postmortem exams in nonhuman primates during yellow fever epizootic in Sorocaba Metropolitan Region (RMS), SP, Brazil","authors":"R. F. Teixeira, Thais Eleonora Madeira Buti, André Luiz Mota da Costa","doi":"10.46958/rcv.2018.xxiii.n.137.p.32-42","DOIUrl":"https://doi.org/10.46958/rcv.2018.xxiii.n.137.p.32-42","url":null,"abstract":"Main mortality causes of neotropical primates are trauma and viral, bacterial and parasitic diseases. In all cases of animal death necropsy, histopathology, and complementary exams are essential to determine the cause of death. Between May 2017 and May 2018, 59 cases of death of non-human primates were registered during the Yellow Fever outbreak in the region of Sorocaba, São Paulo, Brazil. Five species of the genera Callithrix, Alouatta and Sapajus were identified. Wildlife and captivity animals were represented. All biological materials collected during necropsies were submitted to Instituto Adolf Lutz (in São Paulo, Brazil) to be tested for the Yellow Fever virus. Documented causes of death included Yellow Fever, unspecified trauma, interspecies and intraspecies aggression, firearm-induced trauma, pneumonia, and carbamate toxicosis.","PeriodicalId":10255,"journal":{"name":"Clínica Veterinária","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84897702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.46958/rcv.2018.xxiii.n.137.p.24-30
Marcela Fuzeti Gonçalves Netto, Gabryella Fraga Ramos Mello, V. de Marco
Hyperlipidemia in dogs can be primary or secondary. Secondary hyperlipidemia is the most frequent form, and it is associated to endocrine disorders, obesity, and glucocorticoid therapy. Primary hypertriglyceridemia of Miniature Schnauzers is a well-known condition and may predispose to the development of pancreatitis, diabetes, liver and neurological disorders. The goal of this study was to identify the prevalence of hyperlipidemia in 55 asymptomatic Miniature Schnauzers, and the frequency of hepatic changes and insulin resistance in hyperlipidemic dogs. Of the 55 dogs in the study, 56.4% had primary hyperlipidemia. In 23.6% of these cases, the hyperlipidemia was characterized by isolated hypertriglyceridemia, while isolated hypercholesterolemia was present in 20% of the cases. Mixed hyperlipidemia was observed in 12.7% of hyperlipidemic dogs. Hypertriglyceridemia was considered mild in 21/8% of the cases, and moderate to severe in 14.5% of them. Serum ALT was elevated in 32.3% of hyperlipidemic dogs and serum AF was elevated in 38.7% of the cases. Insulin resistance was observed in 90.3% of hyperlipidemic dogs. Given the high prevalence of hyperlipidemia in our sample, and the observed metabolic changes in hyperlipidemic dogs, we suggest that all Miniature Schnauzers are screened for hyperlipidemia as an aid to early diagnosis of this disorder and prevention of complications.
{"title":"Evaluation of the frequency of fasting and postprandial hyperlipidemia in healthy Schnauzers and of hepatic changes and insulin resistance in hyperlipidemic Schnauzers","authors":"Marcela Fuzeti Gonçalves Netto, Gabryella Fraga Ramos Mello, V. de Marco","doi":"10.46958/rcv.2018.xxiii.n.137.p.24-30","DOIUrl":"https://doi.org/10.46958/rcv.2018.xxiii.n.137.p.24-30","url":null,"abstract":"Hyperlipidemia in dogs can be primary or secondary. Secondary hyperlipidemia is the most frequent form, and it is associated to endocrine disorders, obesity, and glucocorticoid therapy. Primary hypertriglyceridemia of Miniature Schnauzers is a well-known condition and may predispose to the development of pancreatitis, diabetes, liver and neurological disorders. The goal of this study was to identify the prevalence of hyperlipidemia in 55 asymptomatic Miniature Schnauzers, and the frequency of hepatic changes and insulin resistance in hyperlipidemic dogs. Of the 55 dogs in the study, 56.4% had primary hyperlipidemia. In 23.6% of these cases, the hyperlipidemia was characterized by isolated hypertriglyceridemia, while isolated hypercholesterolemia was present in 20% of the cases. Mixed hyperlipidemia was observed in 12.7% of hyperlipidemic dogs. Hypertriglyceridemia was considered mild in 21/8% of the cases, and moderate to severe in 14.5% of them. Serum ALT was elevated in 32.3% of hyperlipidemic dogs and serum AF was elevated in 38.7% of the cases. Insulin resistance was observed in 90.3% of hyperlipidemic dogs. Given the high prevalence of hyperlipidemia in our sample, and the observed metabolic changes in hyperlipidemic dogs, we suggest that all Miniature Schnauzers are screened for hyperlipidemia as an aid to early diagnosis of this disorder and prevention of complications.","PeriodicalId":10255,"journal":{"name":"Clínica Veterinária","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83902138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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