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Myostatin, activin-A and follistatin are produced by the tumor in head and neck cancer and likely contribute to sarcopenia: A case-control, cross-sectional exploratory study 头颈癌肿瘤产生肌肉生长抑制素、激活素a和卵泡抑素，可能导致肌肉减少症：一项病例对照、横断面探索性研究。
IF 2.6 Q3 NUTRITION & DIETETICS
Clinical nutrition ESPEN
Pub Date : 2025-12-02 DOI: 10.1016/j.clnesp.2025.11.159
Nicolas Saroul , Alexis Dissard , Bruno Pereira , Thierry Mom , Yves Boirie , Laurent Gilain , Mathilde Puechmaille , Veronique Patrac , Jérôme Salles , Stéphane Walrand

Background and aims

Myostatin (M), activin-A (A) and follistatin (F), three TGF-β superfamily members, play a role in cancer sarcopenia. The aim of our study was to assess the association of MAF in head and neck cancer (HNC) skeletal muscle loss.

Materials and methods

This prospective study involved 55 patients, 32 with HNC and 23 controls. The patients underwent a full nutritional assessment just before surgery. Tumor, muscle and plasma were harvested at the time of surgery. Plasma was harvested a second time 7 days after the procedure. Tumor explants were cultured and MAF were measured in the incubation medium.

Results

A and F plasma levels were higher in cancer patients compared to control (320 vs. 203 pg/ml, p < 0.001, ES = 0.96 95 % CI [0.40; 1.52] and 3593 vs 2148 pg/ml, p < 0.001, ES = 1.10 95%CI [0.53; 1.66], respectively) and M plasma level lower (1542 vs. 2100 pg/ml, p = 0.01, ES = −0.70 95%CI [-1.24; −0.15]). M plasma level was correlated with the skeletal muscle index at the third lumbar vertebra (r = 0.44; p < 0.05) and negatively correlated with weight loss (r = −0.65; p < 0.05) and the C Reactive protein level (−0.44; p = 0.02). At the seventh postoperative day (D), A was increased (D7 vs D0) in the cancer group (379 vs 320 pg/ml; p < 0.001) while the concentrations of M and F were unchanged from the presurgical level. There was no difference between groups in the transcript levels of M and A in skeletal muscles. MAF were systematically detected in the tumor incubation medium with no correlation between tumor incubation medium level and plasma level at D0.

Conclusion

The MAF secretory profile is modified in HNC. In particular, A seems to play a role in muscle loss while F protects against skeletal muscle mass loss.
背景与目的：肌生长抑制素（Myostatin， M）、激活素-A （activin-A， A）和卵泡抑素（follistatin， F）是TGF-β超家族的三个成员，在癌症肌肉减少症中发挥作用。我们研究的目的是评估MAF与头颈癌（HNC）骨骼肌损失的关系。材料和方法：本前瞻性研究纳入55例患者，其中32例为HNC， 23例为对照。患者在手术前接受了全面的营养评估。手术时收集肿瘤、肌肉和血浆。术后7天第二次采集血浆。培养肿瘤外植体，在培养液中测定MAF。结果：癌症患者血浆A和F水平高于对照组（320比203 pg/ml， p）。结论：HNC患者的MAF分泌谱发生改变。特别是，A似乎在肌肉损失中起作用，而F则防止骨骼肌质量损失。
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引用次数: 0
Modulation of ceramides through nutrition: A new target in obesity and insulin resistance (Narrative Review) 神经酰胺通过营养调节：肥胖和胰岛素抵抗的新靶点。
IF 2.6 Q3 NUTRITION & DIETETICS
Clinical nutrition ESPEN
Pub Date : 2025-12-02 DOI: 10.1016/j.clnesp.2025.11.156
Ana T. Arias-Marroquín , Ivan Torre-Villalvazo , Omar Granados Portillo , Mariana Villegas-Romero , Alberto Camacho-Morales , Armando R. Tovar , Carlos A. Aguilar Salinas , Daniel Illescas-Zárate , Natalia Vázquez-Manjarrez

Background

Ceramides (Cer) are signaling sphingolipids that participate in insulin signaling, mitochondrial integrity, and inflammation. In obesity and insulin resistance (IR), Cer biosynthesis is exacerbated, leading to metabolic dysfunction and chronic diseases.

Objective

This narrative review synthesizes current evidence on how Cer metabolism can be modulated through dietary components and dietary patterns, with emphasis on lipidomic analyses.

Key findings

The synthesis and accumulation of Cer are influenced by dietary abundance and quality, such as carbohydrates, fat and phenolic compounds. High-fructose corn syrup and saturated fatty acids promote Cer accumulation and IR, while monounsaturated and polyunsaturated fatty acids—abundant in the Mediterranean and Nordic diets—attenuate these effects. Polyphenol-rich foods and caloric restriction may also reduce Cer concentrations and improve metabolic markers. The emerging evidence from lipidomic analyses is expanding our knowledge on the role of diet in Cer modulation.

Conclusion

Nutritional strategies targeting ceramide metabolism represent a promising approach to improve metabolic health. Beyond their therapeutic potential, ceramides also emerge as dynamic lipidomic biomarkers capable of reflecting early metabolic changes and monitoring the efficacy of nutritional interventions.
背景：神经酰胺（Cer）是参与胰岛素信号传导、线粒体完整性和炎症的神经鞘脂。在肥胖和胰岛素抵抗（IR）中，Cer生物合成加剧，导致代谢功能障碍和慢性疾病。目的：本文综述了目前关于膳食成分和饮食模式如何调节Cer代谢的证据，重点是脂质组学分析。主要发现：Cer的合成和积累受膳食丰度和质量（如碳水化合物、脂肪和酚类化合物）的影响。高果糖玉米糖浆和饱和脂肪酸促进Cer积累和IR，而地中海和北欧饮食中丰富的单不饱和脂肪酸和多不饱和脂肪酸则减弱这些影响。富含多酚的食物和热量限制也可以降低Cer浓度并改善代谢指标。来自脂质组学分析的新证据正在扩大我们对饮食在Cer调节中的作用的认识。结论：以神经酰胺代谢为目标的营养策略是改善代谢健康的一种有前景的途径。除了它们的治疗潜力，神经酰胺还作为动态脂质组学生物标志物出现，能够反映早期代谢变化并监测营养干预的效果。
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引用次数: 0
Positive clinical outcomes associated with use of glucagon-like peptide-2 (GLP-2) analogues in patients with intestinal failure: A systematic review and meta-analysis 肠衰竭患者使用胰高血糖素样肽-2 （GLP-2）类似物相关的阳性临床结果：一项系统回顾和荟萃分析
IF 2.6 Q3 NUTRITION & DIETETICS
Clinical nutrition ESPEN
Pub Date : 2025-12-02 DOI: 10.1016/j.clnesp.2025.11.132
Alysia Bastas , Kyle Williams , Darren Wong

Aim

Glucagon-like peptide-2 analogues are part of the treatment algorithm for chronic intestinal failure to improve enteral nutrient absorption and reduce reliance on parenteral support. The purpose of this review is to update, consolidate and comprehensively evaluate the existing body of evidence, highlighting the breadth of positive clinical outcomes associated with glucagon-like peptide-2 analogue treatment.

Methods

A systematic review was conducted using OVID Medline, Embase, Cochrane Library, CINAHL, and Web of Science. Studies reporting on glucagon-like peptide-2 analogue use in adults focusing on any change in clinical outcomes were included, while studies reporting solely biochemical outcomes were excluded. Meta-analyses and meta-regressions were conducted using R software. Where insufficient data was present, results were pooled and weighted by sample size or presented as a narrative synthesis.

Results

23 studies were included in the final review and analysis. Teduglutide demonstrated a positive and incremental effect on the proportion of short bowel syndrome-associated intestinal failure patients achieving a ≥20 % reduction in PS requirements, with response rates increasing from 64 % (95 % CI: 51 %–75 %) at 6 months to 73 % (95 % CI: 65 %–80 %) after ≥2 years of therapy. A similar trend was observed in patients achieving enteral autonomy, which rose from 13 % (95 % CI: 6 %–25 %) at 6 months to 31 % (95 % CI: 23 %–40 %) after ≥2 years of treatment. Moreover, early data shows teduglutide to have a positive effect on quality of life and stool characteristics of patients. Teduglutide appears to be an acceptable therapy, with a discontinuation rate of 14 %. Early reports suggest similar benefits for emerging GLP-2 including glepaglutide and apraglutide.
目的：胰高血糖素样肽-2类似物是慢性肠衰竭治疗算法的一部分，可改善肠内营养吸收，减少对肠外支持的依赖。本综述的目的是更新、巩固和全面评估现有的证据，强调与胰高血糖素样肽-2类似物治疗相关的积极临床结果的广度。方法：采用OVID Medline、Embase、Cochrane Library、CINAHL、Web of Science进行系统评价。报告成人使用胰高血糖素样肽-2类似物的临床结果变化的研究被纳入，而仅报告生化结果的研究被排除。采用R软件进行meta分析和meta回归。在数据不足的情况下，对结果进行汇总，并按样本量进行加权，或以叙事综合的形式呈现。结果：23项研究被纳入最终的回顾和分析。Teduglutide对短肠综合征相关肠衰竭患者达到PS要求降低≥20%的比例具有积极和递增的作用，治疗≥2年后，缓解率从6个月时的64% （95% CI: 51%-75%）增加到73% （95% CI: 65%-80%）。在获得肠内自主的患者中也观察到类似的趋势，在治疗≥2年后，从6个月时的13% （95% CI: 6%-25%）上升到31% （95% CI: 23%-40%）。此外，早期数据显示，teduglutide对患者的生活质量和粪便特征有积极的影响。Teduglutide似乎是一种可接受的治疗，停药率为14%。早期的报告显示，包括格列鲁肽和阿普鲁肽在内的新兴GLP-2也有类似的益处。
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引用次数: 0
Development of an instantly reconstitutable powdered broth as a clear fluid to shorten preoperative fasting 开发一种可瞬间重构的粉状肉汤作为一种透明液体，以缩短术前禁食时间。
IF 2.6 Q3 NUTRITION & DIETETICS
Clinical nutrition ESPEN
Pub Date : 2025-12-02 DOI: 10.1016/j.clnesp.2025.11.164
Alana Smaniotto Biolo , Rafael Vinícius Patzer , Rosicler Colet , Ana Luiza Lira , Geciane Toniazzo Backes , Jamile Zeni , André Keng Wei Hsu

Objective

This study aimed to develop and validate an instant powdered broth, reconstitutable as a clear liquid, to shorten preoperative fasting, in accordance with ERAS and ACERTO protocols. Prolonged fasting is associated with discomfort, increased insulin resistance, and delayed recovery, while carbohydrate-rich clear liquids consumed up to 2 h before anesthesia are considered safe and beneficial.

Methods

Three formulations were prepared using maltodextrin, glucose, sodium chloride, and chicken flavoring, all fat-free and with high caloric value. After microbiological and sensory analyses with 30 evaluators, the most accepted formulation was selected for physicochemical characterization and clinical evaluation. Gastric emptying was assessed in 29 healthy volunteers (18–65 years) after consumption of 200 mL of the broth 2 h before elective surgery. Gastric ultrasound was performed in 28 participants using standardized qualitative assessment of the gastric antrum, while one participant underwent abdominal computed tomography (CT) solely as an illustrative and confirmatory imaging method. Subjective perceptions of satiety, thirst, palatability, and satisfaction were collected through questionnaires.

Results

The product showed pH 5.17, low water activity, clear appearance, and microbiological safety. Imaging demonstrated adequate gastric emptying in all participants 2 h after consumption. Subjectively, 60 % reported complete satiety, 75 % absence of thirst, 71 % approved palatability, and 92 % expressed overall satisfaction.

Conclusion

The developed broth proved to be a safe, palatable, and effective clear fluid alternative to reduce preoperative fasting, offering an innovative, low-cost option with potential application in hospital settings and personalized nutritional therapy.
目的：本研究旨在根据ERAS和ACERTO协议，开发和验证一种可重构为透明液体的速溶粉状肉汤，以缩短术前禁食时间。长时间禁食与不适、胰岛素抵抗增加和恢复延迟有关，而在麻醉前两小时摄入富含碳水化合物的透明液体被认为是安全有益的。方法：以麦芽糖糊精、葡萄糖、氯化钠和鸡肉香精为原料，制备三种无脂高热值配方。经过30位评价者的微生物学和感官分析，选择最被接受的配方进行理化表征和临床评价。29名健康志愿者（18-65岁）在择期手术前2小时饮用200 mL肉汤后，评估胃排空情况。对28名参与者进行胃超声检查，对胃窦进行标准化的定性评估，同时对1名参与者进行腹部计算机断层扫描（CT），作为一种说明性和确证性成像方法。通过问卷调查收集饱腹感、口渴感、适口性和满意度的主观感知。结果：该产品pH值为5.17，水活度低，外观透明，微生物安全。成像显示所有参与者在进食后两小时胃排空充足。主观上，60%的人表示完全饱腹，75%的人不感到口渴，71%的人认为可口，92%的人表示总体满意。结论：所开发的肉汤被证明是一种安全、可口、有效的透明液体替代品，可以减少术前禁食，为医院环境和个性化营养治疗提供了一种创新、低成本的选择。
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引用次数: 0
Multiple regression models to predict electrical bioimpedance variables through anthropometric and simple measures in children aged 6–12 years 通过人体测量和简单测量预测6至12岁儿童电生物阻抗变量的多元回归模型。
IF 2.6 Q3 NUTRITION & DIETETICS
Clinical nutrition ESPEN
Pub Date : 2025-12-02 DOI: 10.1016/j.clnesp.2025.11.162
Paulo Roberto Santos Lopes , Gisele Bailich , Vinicius Layter Xavier , Igor Lima , Danubia da Cunha de Sá-Caputo , Redha Taiar , Katarzyna Zaborowska-Sapeta , Mario Bernardo-Filho , André Everton de Freitas , Anelise Sonza

Background and aims

Obesity is one of the most common nutritional and metabolic disorders worldwide, affecting all age groups. Multiple regression models can be used to predict bioelectrical impedance analysis (BIA) variables in various populations. These models incorporate a set of anthropometric and simple measures to improve the accuracy of predicting BIA variables. The goal was to develop and internally validate multiple regression models to predict BIA variables using simple clinical and anthropometric measurements in children aged 6–12 years.

Methods

This study employs an observational cross-sectional design. Body mass, height, body composition through BIA, anthropometric circumferences, and skinfolds were evaluated. Anthropometric indices were calculated. Statistical analyses were performed using R software. Non-parametric statistical tests were applied after a normality test. Pearson's correlation coefficients were calculated to assess linear associations between each pair of variables. The multiple regression models were adjusted using a stepwise method with the Akaike information criterion. The significance level was p ≤ 0.05.

Results

This study evaluated 128 children subdivided into eutrophic (N = 64) matched for sex and age with overweight (N = 30) and obese (N = 34) groups matched by sex and age. Significant correlations were observed between BIA variables and simple clinical and anthropometric measurements. Variables with the highest correlations with simple clinical and anthropometric measurements were body fat percentage, skeletal muscle mass, total body water, and fat-free mass, respectively.

Conclusions

Multiple regression analysis indicated that simple clinical and anthropometric measurements could be used to estimate BIA variables in children.
背景和目的：肥胖是世界上最常见的营养和代谢紊乱之一，影响所有年龄组。多元回归模型可用于预测不同种群的生物电阻抗分析（BIA）变量。这些模型结合了一套人体测量和简单的措施，以提高预测BIA变量的准确性。目的是开发并内部验证多元回归模型，通过简单的临床和人体测量来预测6-12岁儿童的电生物阻抗（BIA）变量。方法：本研究采用观察性横断面设计。通过BIA评估体重、身高、身体成分、人体测量周长和皮肤褶皱。计算人体测量指数。采用R软件进行统计分析。正态性检验后应用非参数统计检验。计算Pearson相关系数以评估每对变量之间的线性关联。采用赤池信息准则逐步调整多元回归模型。显著性水平p≤0.05。结果：本研究评估了128名儿童，按性别和年龄分为富营养化组（N=64），按性别和年龄分为超重组（N=30）和肥胖组（N=34）。BIA变量与简单的临床和人体测量值之间存在显著相关性。与简单临床和人体测量值相关性最高的变量分别是体脂率、骨骼肌质量、全身水分和无脂质量。结论：多元回归分析表明，简单的临床和人体测量可用于估计儿童BIA变量。
{"title":"Multiple regression models to predict electrical bioimpedance variables through anthropometric and simple measures in children aged 6–12 years","authors":"Paulo Roberto Santos Lopes ,&nbsp;Gisele Bailich ,&nbsp;Vinicius Layter Xavier ,&nbsp;Igor Lima ,&nbsp;Danubia da Cunha de Sá-Caputo ,&nbsp;Redha Taiar ,&nbsp;Katarzyna Zaborowska-Sapeta ,&nbsp;Mario Bernardo-Filho ,&nbsp;André Everton de Freitas ,&nbsp;Anelise Sonza","doi":"10.1016/j.clnesp.2025.11.162","DOIUrl":"10.1016/j.clnesp.2025.11.162","url":null,"abstract":"<div><h3>Background and aims</h3><div>Obesity is one of the most common nutritional and metabolic disorders worldwide, affecting all age groups. Multiple regression models can be used to predict bioelectrical impedance analysis (BIA) variables in various populations. These models incorporate a set of anthropometric and simple measures to improve the accuracy of predicting BIA variables. The goal was to develop and internally validate multiple regression models to predict BIA variables using simple clinical and anthropometric measurements in children aged 6–12 years.</div></div><div><h3>Methods</h3><div>This study employs an observational cross-sectional design. Body mass, height, body composition through BIA, anthropometric circumferences, and skinfolds were evaluated. Anthropometric indices were calculated. Statistical analyses were performed using R software. Non-parametric statistical tests were applied after a normality test. Pearson's correlation coefficients were calculated to assess linear associations between each pair of variables. The multiple regression models were adjusted using a stepwise method with the Akaike information criterion. The significance level was p ≤ 0.05.</div></div><div><h3>Results</h3><div>This study evaluated 128 children subdivided into eutrophic (N = 64) matched for sex and age with overweight (N = 30) and obese (N = 34) groups matched by sex and age. Significant correlations were observed between BIA variables and simple clinical and anthropometric measurements. Variables with the highest correlations with simple clinical and anthropometric measurements were body fat percentage, skeletal muscle mass, total body water, and fat-free mass, respectively.</div></div><div><h3>Conclusions</h3><div>Multiple regression analysis indicated that simple clinical and anthropometric measurements could be used to estimate BIA variables in children.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"71 ","pages":"Article 102842"},"PeriodicalIF":2.6,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding dietary beliefs, behaviors, and barriers in inflammatory bowel disease: A scoping review 理解炎症性肠病的饮食信念、行为和障碍：一项范围综述。
IF 2.6 Q3 NUTRITION & DIETETICS
Clinical nutrition ESPEN
Pub Date : 2025-12-01 DOI: 10.1016/j.clnesp.2025.11.133
C.V. Noejovich, P. Miranda, G.H. Rueda, Y. Yuan, J. Szeto, R. Patel, H. Zafar, M. Tedesco, D. Armstrong

Background

The connection between diet, disease activity, and symptoms in inflammatory bowel disease (IBD) has received increasing attention. Although many studies explore associations between dietary patterns and IBD, there is limited understanding of patients’ perspectives on dietary modifications and the challenges they encounter in implementing dietary changes. This scoping review aims to address this issue gap.

Aim

To examine the existing evidence on adult IBD patients’ perspectives on dietary modifications for symptom management and identify knowledge gaps for future research.

Methods

This scoping review followed the Joanna Briggs Institute (JBI) methodology. We searched MEDLINE (Ovid, from 1946) and Embase (Ovid, from 1974) until June 26, 2024. Qualitative, quantitative, and mixed-methods studies published in English that reported on IBD patients' perspectives, behaviors, and challenges regarding diet modification were included. Reference lists of relevant reviews were manually screened. No statistical comparisons were performed.

Results

The search identified 2909 studies, of which 53 met the inclusion criteria. Thirty-four studies focused primarily on patients' beliefs and behaviors regarding diet. Most IBD patients reported modifying their diet after diagnosis (56 %–91 %), most commonly through food avoidance (41–95 %) or by trialing restrictive diets to prevent relapse. Many patients believed diet played a role in IBD onset (8–49.2 %) and relapse prevention (33–74 %). Eighteen studies explored barriers to diet modification, the most commonly reported being negative impacts on social and family life and the unpredictability of dietary effects on overall health. Many patients sought dietary advice online.

Conclusion

Food avoidance and social restrictions are common among IBD patients. While nutrition is believed to play a key role in IBD management, challenges in accessing professional dietary guidance persist. Further research is needed to explore difficulties in implementing dietary changes.
背景：炎症性肠病（IBD）的饮食、疾病活动和症状之间的联系越来越受到关注。尽管许多研究探讨了饮食模式与IBD之间的关系，但对患者对饮食改变的看法以及他们在实施饮食改变时遇到的挑战的了解有限。这一范围审查旨在解决这一问题差距。目的：研究成人IBD患者对饮食改变对症状管理的看法的现有证据，并为未来的研究确定知识空白。方法：本综述采用乔安娜布里格斯研究所（JBI）的方法。我们检索了MEDLINE （Ovid，从1946年开始）和Embase （Ovid，从1974年开始），直到2024年6月26日。本研究纳入了用英语发表的关于IBD患者观点、行为和饮食改变挑战的定性、定量和混合方法研究。人工筛选相关审查的参考列表。没有进行统计学比较。结果：检索到2909项研究，其中53项符合纳入标准。34项研究主要关注患者对饮食的看法和行为。大多数IBD患者报告在诊断后改变饮食（56% - 91%），最常见的是通过避免食物（41% -95%）或尝试限制性饮食来防止复发。许多患者认为饮食在IBD发病（8-49.2%）和预防复发（33-74%）中起作用。18项研究探讨了改变饮食习惯的障碍，最常见的报告是对社会和家庭生活的负面影响，以及饮食对整体健康的不可预测性。许多患者在网上寻求饮食建议。结论：IBD患者普遍存在食物回避和社交限制。虽然营养被认为在IBD管理中发挥着关键作用，但在获得专业饮食指导方面仍然存在挑战。需要进一步的研究来探索实施饮食改变的困难。
{"title":"Understanding dietary beliefs, behaviors, and barriers in inflammatory bowel disease: A scoping review","authors":"C.V. Noejovich,&nbsp;P. Miranda,&nbsp;G.H. Rueda,&nbsp;Y. Yuan,&nbsp;J. Szeto,&nbsp;R. Patel,&nbsp;H. Zafar,&nbsp;M. Tedesco,&nbsp;D. Armstrong","doi":"10.1016/j.clnesp.2025.11.133","DOIUrl":"10.1016/j.clnesp.2025.11.133","url":null,"abstract":"<div><h3>Background</h3><div>The connection between diet, disease activity, and symptoms in inflammatory bowel disease (IBD) has received increasing attention. Although many studies explore associations between dietary patterns and IBD, there is limited understanding of patients’ perspectives on dietary modifications and the challenges they encounter in implementing dietary changes. This scoping review aims to address this issue gap.</div></div><div><h3>Aim</h3><div>To examine the existing evidence on adult IBD patients’ perspectives on dietary modifications for symptom management and identify knowledge gaps for future research.</div></div><div><h3>Methods</h3><div>This scoping review followed the Joanna Briggs Institute (JBI) methodology. We searched MEDLINE (Ovid, from 1946) and Embase (Ovid, from 1974) until June 26, 2024. Qualitative, quantitative, and mixed-methods studies published in English that reported on IBD patients' perspectives, behaviors, and challenges regarding diet modification were included. Reference lists of relevant reviews were manually screened. No statistical comparisons were performed.</div></div><div><h3>Results</h3><div>The search identified 2909 studies, of which 53 met the inclusion criteria. Thirty-four studies focused primarily on patients' beliefs and behaviors regarding diet. Most IBD patients reported modifying their diet after diagnosis (56 %–91 %), most commonly through food avoidance (41–95 %) or by trialing restrictive diets to prevent relapse. Many patients believed diet played a role in IBD onset (8–49.2 %) and relapse prevention (33–74 %). Eighteen studies explored barriers to diet modification, the most commonly reported being negative impacts on social and family life and the unpredictability of dietary effects on overall health. Many patients sought dietary advice online.</div></div><div><h3>Conclusion</h3><div>Food avoidance and social restrictions are common among IBD patients. While nutrition is believed to play a key role in IBD management, challenges in accessing professional dietary guidance persist. Further research is needed to explore difficulties in implementing dietary changes.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"71 ","pages":"Article 102818"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sufficient rate comparison of Harris-Benedict basal metabolic energy expenditure and Cunningham basal metabolic rate for the weight loss rate in allogeneic hematopoietic stem cell transplantation Harris-Benedict基础代谢能量消耗和Cunningham基础代谢率对同种异体造血干细胞移植减重率的足够率比较
IF 2.6 Q3 NUTRITION & DIETETICS
Clinical nutrition ESPEN
Pub Date : 2025-12-01 DOI: 10.1016/j.clnesp.2025.11.020
Takashi Aoyama

Background & aims

We aimed to compare the Harris–Benedict Basal Energy Expenditure (HBEE) and the Cunningham Basal Metabolic Rate (CBMR) in relation to weight loss rate (percentage loss of body weight [%LBW]) among patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).

Methods

Patients who underwent HSCT (transplant date = day 0) at the Division of Stem Cell Transplantation, Shizuoka Cancer Center, between January 2022 and June 2023 were included. We evaluated the association between weight loss rate from the day before pre-treatment to day 42 and the sufficiency of each calculated basal metabolic value.

Results

A total of 31 patients (median age, 53 years; interquartile range, 37–60; 17 male individuals) were analyzed. The median %LBW was −5.0 % (range: −31.2–7.6). %LBW was significantly correlated with sufficiency of HBEE based on current weight (97 %), HBEE based on standard weight (94 %), and CBMR (96 %) (r = 0.56, r = 0.44, r = 0.52, respectively). Using a cutoff of 7.5 % LBW, sufficiency rates were associated with weight loss (odds ratios: 1.08; 95 % confidence interval [CI]: 1.02–1.17; 1.07; 95 % CI: 1.01–1.14; and 1.05; 95 % CI: 1.01–1.11, respectively).

Conclusion

Post-HSCT weight loss was significantly correlated with HBEE (based on both current and standard weight) and CBMR sufficiency, suggesting that these calculations may provide useful indicators for nutritional management following HSCT.
背景与目的：我们旨在比较Harris-Benedict基础能量消耗（HBEE）和Cunningham基础代谢率（CBMR）与接受同种异体造血干细胞移植（HSCT）患者体重减轻率（体重减轻百分比[%LBW]）的关系。方法：纳入2022年1月至2023年6月期间在静冈癌症中心干细胞移植部接受HSCT（移植日期=第0天）的患者。我们评估了从治疗前一天到第42天的体重减轻率与计算的基础代谢值的充分性之间的关系。结果：共分析31例患者（中位年龄53岁，四分位数范围37 ~ 60岁，男性17例）。中位%LBW为-5.0%（范围：-31.2-7.6）。LBW %与基于当前体重的HBEE充分性（97%）、基于标准体重的HBEE充分性（94%）和CBMR充分性（96%）显著相关（r=0.56、r=0.44、r=0.52）。使用7.5%的LBW截断值，充足率与体重减轻相关（优势比：1.08；95%可信区间[CI]: 1.02-1.17; 1.07; 95% CI: 1.01-1.14；和1.05;95% CI: 1.01-1.11）。结论：HSCT后体重减轻与HBEE（基于当前体重和标准体重）和CBMR充分性显著相关，表明这些计算可能为HSCT后的营养管理提供有用的指标。
{"title":"Sufficient rate comparison of Harris-Benedict basal metabolic energy expenditure and Cunningham basal metabolic rate for the weight loss rate in allogeneic hematopoietic stem cell transplantation","authors":"Takashi Aoyama","doi":"10.1016/j.clnesp.2025.11.020","DOIUrl":"10.1016/j.clnesp.2025.11.020","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>We aimed to compare the Harris–Benedict Basal Energy Expenditure (HBEE) and the Cunningham Basal Metabolic Rate (CBMR) in relation to weight loss rate (percentage loss of body weight [%LBW]) among patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).</div></div><div><h3>Methods</h3><div>Patients who underwent HSCT (transplant date = day 0) at the Division of Stem Cell Transplantation, Shizuoka Cancer Center, between January 2022 and June 2023 were included. We evaluated the association between weight loss rate from the day before pre-treatment to day 42 and the sufficiency of each calculated basal metabolic value.</div></div><div><h3>Results</h3><div>A total of 31 patients (median age, 53 years; interquartile range, 37–60; 17 male individuals) were analyzed. The median %LBW was −5.0 % (range: −31.2–7.6). %LBW was significantly correlated with sufficiency of HBEE based on current weight (97 %), HBEE based on standard weight (94 %), and CBMR (96 %) (r = 0.56, r = 0.44, r = 0.52, respectively). Using a cutoff of 7.5 % LBW, sufficiency rates were associated with weight loss (odds ratios: 1.08; 95 % confidence interval [CI]: 1.02–1.17; 1.07; 95 % CI: 1.01–1.14; and 1.05; 95 % CI: 1.01–1.11, respectively).</div></div><div><h3>Conclusion</h3><div>Post-HSCT weight loss was significantly correlated with HBEE (based on both current and standard weight) and CBMR sufficiency, suggesting that these calculations may provide useful indicators for nutritional management following HSCT.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"70 ","pages":"Pages 684-691"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor: Comment on “Addressing nutritional risk and dehydration in vulnerable older adults in the emergency department: A single-arm feasibility study on detection, treatment, and follow-up” 致编辑的信：关于“解决急诊科脆弱老年人的营养风险和脱水问题：一项关于检测、治疗和随访的单臂可行性研究”的评论。
IF 2.6 Q3 NUTRITION & DIETETICS
Clinical nutrition ESPEN
Pub Date : 2025-12-01 DOI: 10.1016/j.clnesp.2025.09.013
Shashank Dokania, Parth Aphale, Himanshu Shekhar
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引用次数: 0
Letter to the Editor: Nutritional status in retroperitoneal sarcoma: Implication of prognostic Nutritional Index (PNI) and skeletal muscle index (SMI) on postoperative and oncological outcomes 致编辑的信：腹膜后肉瘤的营养状况：预后营养指数（PNI）和骨骼肌指数（SMI）对术后和肿瘤预后的影响。
IF 2.6 Q3 NUTRITION & DIETETICS
Clinical nutrition ESPEN
Pub Date : 2025-12-01 DOI: 10.1016/j.clnesp.2025.08.025
Leela Kumaran, Sheifali Gupta
{"title":"Letter to the Editor: Nutritional status in retroperitoneal sarcoma: Implication of prognostic Nutritional Index (PNI) and skeletal muscle index (SMI) on postoperative and oncological outcomes","authors":"Leela Kumaran,&nbsp;Sheifali Gupta","doi":"10.1016/j.clnesp.2025.08.025","DOIUrl":"10.1016/j.clnesp.2025.08.025","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"70 ","pages":"Pages 723-724"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of blood Omega-3 fatty acid, inflammatory markers, and lung function in UK biobank participants with inflammatory bowel disease 血液Omega-3脂肪酸、炎症标志物和肺功能在英国生物库炎症性肠病参与者中的关联
IF 2.6 Q3 NUTRITION & DIETETICS
Clinical nutrition ESPEN
Pub Date : 2025-12-01 DOI: 10.1016/j.clnesp.2025.11.160
Hsien-Yu Fan , Yih-Jong Chern , Hsin-Yin Hsu , Po-Jui Lai , Ming-Chieh Tsai , Kuo-Liong Chien , Chih-Jun Lai , Chiu-Li Yeh

Background

Blood omega-3 fatty acids have been linked to inflammatory markers and lung function, but their effects in participants with inflammatory bowel disease (IBD) remain unclear.

Objective

This study aimed to investigate inflammatory markers in the relationship between blood omega-3 fatty acids and lung function in IBD participants and subtypes.

Design, setting and patients

A total of 497,134 UK Biobank participants were screened, and 3340 participants with IBD were included in the analysis.

Exposures and outcomes

Participants were classified into quintiles based on blood omega-3 fatty acid levels (% of total fatty acids), with Q1 as the reference. Linear regression compared inflammatory markers across quintiles. We then examined how inflammatory markers might link omega-3 levels to lung function.

Results

IBD participants, particularly those with Crohn's disease, showed stronger reductions in inflammatory biomarkers—white blood cells, basophils, neutrophils, neutrophil-to-lymphocyte ratios, and C-reactive protein (CRP) (p < 0.001)—at higher omega-3 levels. CRP and neutrophils were potential mediators between omega-3 levels and lung function (FEV1 and FVC). A 1 % increase in omega-3 levels reduced CRP by 0.27 mg/L and neutrophils by 0.07 × 109 cells/L, corresponding to reductions of 10.88 mL in FEV1 and 12.36 mL in FVC for CRP, and 38.20 mL in FEV1 and 39.36 mL in FVC for neutrophils. Mediation analysis showed that CRP and neutrophils accounted for 21 % (p = 0.01) and 18 % (p = 0.02) of the FEV1 effect, and 22 % (p = 0.049) and 16 % (p = 0.049) of the FVC effect, respectively.

Conclusions

Higher omega-3 fatty acid levels were associated with reduced inflammatory biomarkers, which may also be associated with lung health in individuals with IBD, particularly those with Crohn's disease. Future studies should investigate additional immune mediators, including cytokines and chemokine.
背景：血液中omega-3脂肪酸与炎症标志物和肺功能有关，但其对炎症性肠病（IBD）患者的影响尚不清楚。目的：本研究旨在探讨IBD参与者及其亚型血液中omega-3脂肪酸与肺功能之间的炎症标志物。设计、环境和患者：共有497,134名UK Biobank参与者被筛选，3340名IBD患者被纳入分析。暴露和结果：参与者根据血液中omega-3脂肪酸水平（占总脂肪酸的百分比）分为五分之一，以Q1为参考。线性回归比较了不同五分位数的炎症标志物。然后，我们研究了炎症标志物如何将ω -3水平与肺功能联系起来。结果：IBD参与者，特别是那些患有克罗恩病的参与者，在较高的omega-3水平下，炎症生物标志物-白细胞、嗜碱性粒细胞、中性粒细胞、中性粒细胞与淋巴细胞比率和c反应蛋白（CRP） （p < 0.001）的减少更明显。CRP和中性粒细胞是omega-3水平与肺功能（FEV1和FVC）之间的潜在介质。omega-3水平增加1%，CRP降低0.27 mg/L，中性粒细胞降低0.07 × 109个细胞/L，对应于CRP降低10.88 mL FEV1和12.36 mL FVC，中性粒细胞降低38.20 mL FEV1和39.36 mL FVC。中介分析显示，CRP和中性粒细胞分别占FEV1效应的21% （p = 0.01）和18% (p = 0.02)，占FVC效应的22% （p = 0.049）和16% （p = 0.049）。结论：较高的omega-3脂肪酸水平与炎症生物标志物减少有关，这也可能与IBD患者，特别是克罗恩病患者的肺部健康有关。未来的研究应探讨更多的免疫介质，包括细胞因子和趋化因子。
{"title":"Associations of blood Omega-3 fatty acid, inflammatory markers, and lung function in UK biobank participants with inflammatory bowel disease","authors":"Hsien-Yu Fan ,&nbsp;Yih-Jong Chern ,&nbsp;Hsin-Yin Hsu ,&nbsp;Po-Jui Lai ,&nbsp;Ming-Chieh Tsai ,&nbsp;Kuo-Liong Chien ,&nbsp;Chih-Jun Lai ,&nbsp;Chiu-Li Yeh","doi":"10.1016/j.clnesp.2025.11.160","DOIUrl":"10.1016/j.clnesp.2025.11.160","url":null,"abstract":"<div><h3>Background</h3><div>Blood omega-3 fatty acids have been linked to inflammatory markers and lung function, but their effects in participants with inflammatory bowel disease (IBD) remain unclear.</div></div><div><h3>Objective</h3><div>This study aimed to investigate inflammatory markers in the relationship between blood omega-3 fatty acids and lung function in IBD participants and subtypes.</div></div><div><h3>Design, setting and patients</h3><div>A total of 497,134 UK Biobank participants were screened, and 3340 participants with IBD were included in the analysis.</div></div><div><h3>Exposures and outcomes</h3><div>Participants were classified into quintiles based on blood omega-3 fatty acid levels (% of total fatty acids), with Q1 as the reference. Linear regression compared inflammatory markers across quintiles. We then examined how inflammatory markers might link omega-3 levels to lung function.</div></div><div><h3>Results</h3><div>IBD participants, particularly those with Crohn's disease, showed stronger reductions in inflammatory biomarkers—white blood cells, basophils, neutrophils, neutrophil-to-lymphocyte ratios, and C-reactive protein (CRP) (<em>p</em> &lt; 0.001)—at higher omega-3 levels. CRP and neutrophils were potential mediators between omega-3 levels and lung function (FEV<sub>1</sub> and FVC). A 1 % increase in omega-3 levels reduced CRP by 0.27 mg/L and neutrophils by 0.07 × 10<sup>9</sup> cells/L, corresponding to reductions of 10.88 mL in FEV<sub>1</sub> and 12.36 mL in FVC for CRP, and 38.20 mL in FEV<sub>1</sub> and 39.36 mL in FVC for neutrophils. Mediation analysis showed that CRP and neutrophils accounted for 21 % (<em>p</em> = 0.01) and 18 % (<em>p</em> = 0.02) of the FEV1 effect, and 22 % (<em>p</em> = 0.049) and 16 % (<em>p</em> = 0.049) of the FVC effect, respectively.</div></div><div><h3>Conclusions</h3><div>Higher omega-3 fatty acid levels were associated with reduced inflammatory biomarkers, which may also be associated with lung health in individuals with IBD, particularly those with Crohn's disease. Future studies should investigate additional immune mediators, including cytokines and chemokine.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"71 ","pages":"Article 102840"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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