Clinical nutrition ESPEN最新文献

英文中文

Comparison of International Enhanced Recovery After Surgery (ERAS) Outcomes: An ERAS Interactive Audit System (EIAS) Database Study

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN

Pub Date : 2025-02-01 DOI: 10.1016/j.clnesp.2024.10.013

Gregg Nelson ∗ , Abby Thomas , Steven P. Bisch , Hans D. de Boer , Martin Hubner , Khara Sauro

引用次数: 0

The Paradoxical Relationship Among Diabetes Mellitus, Osteoporosis and Sarcopenia: The PARADOS Study 糖尿病对骨质疏松症和肌肉减少症的矛盾影响：paradox研究。

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN

Pub Date : 2025-02-01 DOI: 10.1016/j.clnesp.2024.12.009

Tülay Tiftik , Murat Kara , Cevriye Mülkoğlu , İrem Çiftçi , Ömer Faruk Çelik , Mahmut Esad Durmuş , Özgür Kara , Şerife Mehlika Kuşkonmaz , Hakan Genç , Bayram Kaymak , Levent Özçakar

Introduction

Type 2 diabetes mellitus (DM), osteoporosis (OP) and sarcopenia are major public health problems related with higher fall/fracture risks, morbidity and mortality. Due to the lack of a comprehensive analysis among OP, sarcopenia and DM; we aimed to explore the relationships between DM and the aforementioned conditions in postmenopausal women.

Methods

This cross-sectional study included postmenopausal women who consecutively admitted to the Departments of Physical & Rehabilitation Medicine, and Endocrinology and Metabolism. Demographic data, nutrition/cognition status and frailty scores of the participants were recorded. Sarcopenia-related parameters including, anterior thigh muscle thickness, handgrip strength, chair stand test, gait speed, and one-leg stand test (OLST) were measured. ISarcoPRM algorithm was used for the diagnosis of sarcopenia.

Results

A total of 444 postmenopausal women were consecutively enrolled. DM patients (N = 158) had higher frequency of sarcopenia (23.4 % vs. 12.9 %), but lower frequency of OP (33.5 % vs. 50.7 %) than controls (both p < 0.01). As regards regression analyses; menopause duration was positively (OR: 1.054, 95 % CI 1.030–1.077), but weight (OR: 0.957, 95 % CI 0.940–0.975) and DM (OR: 0.477, 95 % CI 0.310–0.733) were negatively related with OP (all p < 0.001). On the other hand, age (OR: 1.094, 95 % CI 1.056–1.133), body mass index (OR: 1.131, 95 % CI 1.067–1.198), and DM (OR: 1.887, 95 % CI 1.107–3.218) were positively related with sarcopenia (all p < 0.05). In addition, age (β = −0.355, p < 0.001), body mass index (β = −0.108, p = 0.021) and DM (β = −0.209, p < 0.001) were negatively related with OLST values.

Conclusion

DM has paradoxical associations with bone mass and muscle mass/function. Although it has negative relationship with OP (about two times lower odds), it has positive relationship with sarcopenia (about two times higher odds).

导言：2型糖尿病（DM）、骨质疏松症（OP）和肌肉疏松症是与较高的跌倒/骨折风险、发病率和死亡率相关的主要公共健康问题。由于缺乏对骨质疏松症、肌肉疏松症和糖尿病之间关系的全面分析，我们旨在探讨绝经后女性糖尿病与上述疾病之间的关系：这项横断面研究包括连续在物理与康复医学科、内分泌与代谢科住院的绝经后妇女。研究人员记录了参与者的人口统计学数据、营养/认知状况和虚弱评分。测量了与 "肌肉疏松症 "相关的参数，包括大腿前侧肌肉厚度、手握力、椅子站立测试、步速和单腿站立测试（OLST）。采用 ISarcoPRM 算法诊断肌肉疏松症：结果：共有 444 名绝经后妇女连续入选。与对照组相比，DM 患者（158 人）出现肌少症的频率较高（23.4% 对 12.9%），但出现 OP 的频率较低（33.5% 对 50.7%）：DM与骨量和肌肉质量/功能的关系自相矛盾。虽然它与 OP 呈负相关（几率低约两倍），但与肌肉疏松症呈正相关（几率高约两倍）。

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引用次数: 0

Metabolome-wide Mendelian randomization assessing the causal relationship between blood metabolites and primary ovarian insufficiency 全代谢组孟德尔随机化评估血液代谢物与原发性卵巢功能不全之间的因果关系。

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN

Pub Date : 2025-02-01 DOI: 10.1016/j.clnesp.2024.11.013

Yijie Chen , Jun Chen , Ji Wu , Xianguo Qu , Zhifen Zhang

Background & aims

Primary ovarian insufficiency (POI) is a significant clinical syndrome that leads to female infertility, and its incidence continues to increase. We used metabolome-specific Mendelian randomization (MR) to identify causally associated metabolites and explore the relationship between candidate metabolites and upstream genetic variations.

Methods

The primary MR analysis utilized the inverse variance weighted (IVW) method as the primary approach to assess the causal relationship between exposure and POI. Multiple sensitivity analyses included MR-Egger, weighted median, and weighted mode methods.

Results

After using genetic variants as probes, we identified 27 metabolites of 278 that are associated with the risk of POI, including dodecanedioate (OR 0.052, 95 % CI 0.010–0.265; P < 0.001), adrenate (OR 0.113, 95 % CI 0.016–0.822; P = 0.031), indolepropionate (OR 0.174, 95 % CI 0.051–0.593; P = 0.005), homocitrulline (OR 0.194, 95 % CI 0.051–0.741; P = 0.016), and 3-methylhistidine (OR 0.404, 95 % CI 0.193–0.848; P = 0.017). Our study indicated the presence of heterogeneity; therefore, we employed the IVW random-effects model as the primary approach. KEGG pathway enrichment analysis identified six significant metabolic pathways, primarily including biosynthesis of unsaturated fatty acids, phenylalanine, tyrosine and tryptophan biosynthesis, aminoacyl-tRNA biosynthesis, linoleic acid metabolism, valine, leucine and isoleucine biosynthesis, ubiquinone and other terpenoid-quinone biosynthesis.

Conclusions

By integrating genomics and metabolomics, this study provides novel insights into the causal relationship linking circulating metabolites and the onset of POI.

背景与目的：原发性卵巢功能不全（POI）是导致女性不孕症的重要临床综合征，其发病率不断上升。我们使用代谢组特异性孟德尔随机化（MR）来确定因果相关的代谢物，并探索候选代谢物与上游遗传变异之间的关系。方法：主要MR分析采用逆方差加权（IVW）方法作为评估暴露与POI之间因果关系的主要方法。多重敏感性分析包括MR-Egger、加权中位数和加权模式方法。结果：在使用遗传变异作为探针后，我们从278例患者中鉴定出27种与POI风险相关的代谢物，包括十二烷二酸酯(OR 0.052, 95% CI 0.010 - 0.265；P < 0.001)，肾上腺素(OR 0.113, 95% CI 0.016 - 0.822；P = 0.031)，吲哚丙酸酯(OR 0.174, 95% CI 0.051 - 0.593；P = 0.005)，均瓜氨酸(OR 0.194, 95% CI 0.051 - 0.741；P = 0.016)和3-甲基组氨酸(OR 0.404, 95% CI 0.193 - 0.848；P = 0.017)。我们的研究表明存在异质性；因此，我们采用IVW随机效应模型作为主要方法。KEGG途径富集分析确定了6条重要的代谢途径，主要包括不饱和脂肪酸的生物合成、苯丙氨酸、酪氨酸和色氨酸的生物合成、氨基酰基trna的生物合成、亚油酸的生物合成、缬氨酸、亮氨酸和异亮氨酸的生物合成、泛醌和其他萜类醌的生物合成。结论：通过整合基因组学和代谢组学，本研究为循环代谢物与POI发病之间的因果关系提供了新的见解。

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引用次数: 0

Impact of Enhanced Recovery After Surgery Compliance on Venous Thromboembolism Rates

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN

Pub Date : 2025-02-01 DOI: 10.1016/j.clnesp.2024.10.009

Kristin Black, Abby Thomas, Khara Sauro, Gregg Nelson ∗

引用次数: 0

The effect of three different analgesia techniques on pain scores in patients undergoing colorectal surgery with an Enhanced Recovery After Surgery (ERAS) protocol

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN

Pub Date : 2025-02-01 DOI: 10.1016/j.clnesp.2024.10.025

Menekse Ozcelik , Fatih Kurt ∗ , Süheyla Karadağ Erkoç , Hakan Yilmaz , Derya Gokmen , Cihangir Akyol , Mehmet Ali Koç , Sevda Ünver , Neslihan Alkis

引用次数: 0

Impact of Enhanced Recovery After Surgery (ERAS) Protocol Adoption for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) on Analgesia Practices and Patient-Reported Pain

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN

Pub Date : 2025-02-01 DOI: 10.1016/j.clnesp.2024.10.028

Cedar J. Fowler ∗ , Beatrice Sun , Tiffany Yue , Byrne Lee

引用次数: 0

Association between hypovitaminosis D and sarcopenic obesity in patients with chronic kidney disease stages 3 and 4 慢性肾病3期和4期患者维生素D缺乏症与肌肉减少性肥胖的关系

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN

Pub Date : 2025-02-01 DOI: 10.1016/j.clnesp.2024.11.020

Miguel Alvarez-Mejia , Cesar Augusto Restrepo , Felipe Marulanda-Mejia , Clara Helena González-Correa

The relationship between sarcopenic obesity and hypovitaminosis D in individuals with chronic kidney disease is complex and has significant impacts on muscle and bone health. An observational, cross-sectional, and analytical study was conducted to analyze possible associations between serum vitamin D levels and sarcopenic obesity in patients with chronic kidney disease stages 3 and 4 in a cohort of patients under nephrology care. The presence of sarcopenic obesity was assessed using bioimpedance criteria, and vitamin D levels were measured and recorded for each patient. Statistically significant associations were found between sarcopenic obesity and suboptimal vitamin D levels (p < 0.005) as well as between severe sarcopenia and hypovitaminosis D (p < 0.05) in patients with chronic kidney disease stages 3 and 4. Patients with optimal levels of vitamin D showed better muscle quality and a lower prevalence of sarcopenia and severe sarcopenia. The findings suggest that vitamin D levels play a crucial role in muscle quality in patients with CKD stages 3 and 4. Maintaining optimal levels of vitamin D may help reduce the prevalence of sarcopenic obesity and improve quality of life in these patients.

慢性肾脏疾病患者肌肉减少性肥胖与维生素D缺乏症之间的关系是复杂的，对肌肉和骨骼健康有显著影响。通过一项观察性、横断面性和分析性研究，分析慢性肾脏疾病3期和4期患者血清维生素D水平与肌肉减少性肥胖之间可能存在的关联。使用生物阻抗标准评估肌肉减少性肥胖的存在，并测量和记录每个患者的维生素D水平。在慢性肾脏疾病3期和4期患者中，肌肉减少性肥胖与维生素D水平不理想（p < 0.005）以及严重肌肉减少症与维生素D缺乏症（p < 0.05）之间存在有统计学意义的关联。维生素D水平最佳的患者表现出更好的肌肉质量，肌肉减少症和严重肌肉减少症的患病率较低。研究结果表明，维生素D水平在CKD 3期和4期患者的肌肉质量中起着至关重要的作用。维持最佳水平的维生素D可能有助于减少肌肉减少性肥胖的患病率，并改善这些患者的生活质量。

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引用次数: 0

Enhanced Recovery after Surgery(ERAS) in laparoscopic bariatric surgery: A prospective observational non-randomized comparative study

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN

Pub Date : 2025-02-01 DOI: 10.1016/j.clnesp.2024.10.027

Bon-Wook Koo, Young Hyun Koo ∗, Sohyun Lee

引用次数: 0

Diagnostic accuracy of C-reactive protein for the early diagnosis of infectious complications after gastrectomy for gastric cancer: A meta-analysis and systematic review

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN

Pub Date : 2025-02-01 DOI: 10.1016/j.clnesp.2024.10.033

Jianxiao Liu , Xusheng Liu , Chaoyang Wang , Yongjiang Yu ∗

引用次数: 0

Letter to the editor: Comment on “Maternal non-compliance with recommended folic acid supplement use alters global DNA methylation in cord blood of newborns: A cohort study” 致编辑的信关于 "孕产妇不按建议使用叶酸补充剂会改变新生儿脐带血中的 DNA 甲基化：一项队列研究 "的评论。

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN

Pub Date : 2025-02-01 DOI: 10.1016/j.clnesp.2024.10.169

Letícia Van-Lume Lima, Ana Elisa Toscano, Joaci Pereira dos Santos Júnior, Eulália Rebeca da Silva-Araújo, José Geneilson Silva, Raul Manhães-de-Castro

引用次数: 0

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