Clinical nutrition ESPEN最新文献

{"title":"The causal relationship between hydatidiform mole and nutrients: A two-sample Mendelian randomization study","authors":"Guohua Zhu ,&nbsp;Tingting Zhu ,&nbsp;Ruhe Jiang ,&nbsp;Xin Lu ,&nbsp;Yan Du","doi":"10.1016/j.clnesp.2024.09.018","DOIUrl":"10.1016/j.clnesp.2024.09.018","url":null,"abstract":"<div><h3>Background</h3><div>Hydatidiform mole (HM), a subset of gestational trophoblastic disease, is considered precancerous and exhibits geographical variation. The incidence of HM is linked to nutritional factors. This study aimed to investigate the causal relationship between nutrients and HM using a bidirectional two-sample Mendelian randomization (MR) approach.</div></div><div><h3>Methods</h3><div>We utilized publicly available genome-wide association study data to assess the causal associations between levels of specific vitamins (retinol, vitamins B12, B6, C, D, E, folate, and carotene) and minerals (iron, calcium, and magnesium) with HM. The MR analysis was conducted and reported following the STROBE-MR guidelines, employing MR Egger and inverse variance weighted (IVW) methods to estimate associations, with MR-PRESSO for pleiotropy testing.</div></div><div><h3>Results</h3><div>The study revealed vitamin B6 as a significant protective factor against HM (MR-Egger OR: 0.094, 95 % CI: 0.011–0.0778, P &lt; 0.05; IVW OR: 0.365, 95 % CI: 0.142–0.936, P &lt; 0.05). Folate and magnesium showed suggestive associations with HM, whereas most other nutrients did not exhibit a causal relationship. MR-PRESSO analysis supported the absence of horizontal pleiotropy of vitamin B6. Besides, reverse MR analysis did not reveal a significant causal association between HM and serum nutrient levels, suggesting that differences of nutrients in HM patients may not be directly attributed to the mole.</div></div><div><h3>Conclusion</h3><div>This MR study provides evidence that vitamin B6 may protect against HM, and suggests potential roles for folate and magnesium in HM development, while highlighting the need for further research to confirm these findings.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of different doses of daily prophylactic iron supplementation in pregnant women: A systematic review and meta-analysis","authors":"Indar Kumar Sharawat ,&nbsp;Prateek Kumar Panda ,&nbsp;Surbhi Choudhary ,&nbsp;Pranita Pradhan ,&nbsp;Vivek Singh Malik ,&nbsp;Meenu Singh","doi":"10.1016/j.clnesp.2024.09.019","DOIUrl":"10.1016/j.clnesp.2024.09.019","url":null,"abstract":"<div><h3>Introduction</h3><div>Several randomized controlled trials (RCT) have been conducted in the past to determine the optimum dose of iron supplementation during pregnancy, but there is a lack of consensus among different guidelines regarding the appropriate dosage of iron for prophylaxis during pregnancy.</div></div><div><h3>Methods</h3><div>Relevant electronic databases were searched to identify publications describing RCTs comparing different daily dosages of iron supplementation during pregnancy. Meta-analysis for various efficacy and safety outcomes such as changes in blood hemoglobin, serum ferritin, serum iron, and serum transferrin saturation, as well as the frequency of adverse effects, was performed using random and fixed effect models suitably depending on the degree of heterogeneity. Two groups were compared: those receiving 60 mg elemental iron or less and those receiving more than 60 mg elemental iron per day. Additionally, the efficacy of those receiving 30 mg elemental iron per day and those receiving 60 mg elemental iron per day were also compared.</div></div><div><h3>Results</h3><div>A to total of 15 RCTs comprising 2726 participants were included in the meta-analysis. Change in blood hemoglobin levels was comparable between the ≤60 mg/day and &gt;60 mg/day group (pooled estimate for mean difference, 0.01 [-0.11, 0.09], p = 0.86, I² = 96 %), but serum ferritin, iron level, and serum transferrin saturation change were higher in the &gt;60 mg group (p &lt; 0.0001, 0.008, and 0.02, respectively). Change in blood hemoglobin level was better in the 60 mg/day group compared to the 30 mg/day group (pooled estimate for mean difference, −0.11 [-0.21, 0.00], p = 0.04, I² = 90 %), as well as changes in serum ferritin and serum transferrin saturations (p = 0.004 and 0.0004, respectively).</div></div><div><h3>Conclusion</h3><div>Daily supplementation of 60 mg elemental iron is more efficacious than daily supplementation of 30 mg elemental iron for the prophylaxis of anemia in pregnant women (certainty of evidence-moderate), and daily supplementation of ≤60 mg elemental iron is equally efficacious compared to daily supplementation of &gt;60 mg elemental iron for the prophylaxis of anemia in pregnant women (certainty of evidence-moderate).</div></div><div><h3>Proespero registration no</h3><div>CRD42023455485.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized nutritional therapy in a patient with chronic critical illness","authors":"Veronica Ueckermann ,&nbsp;Engela Francis","doi":"10.1016/j.clnesp.2024.09.015","DOIUrl":"10.1016/j.clnesp.2024.09.015","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between phase angle and inflammatory blood biomarkers in community-dwelling older adults: Itabashi Longitudinal Study on Aging","authors":"Sho Hatanaka ,&nbsp;Takashi Shida ,&nbsp;Yosuke Osuka ,&nbsp;Narumi Kojima ,&nbsp;Keiko Motokawa ,&nbsp;Tsuyoshi Okamura ,&nbsp;Hirohiko Hirano ,&nbsp;Shuichi Awata ,&nbsp;Hiroyuki Sasai","doi":"10.1016/j.clnesp.2024.09.017","DOIUrl":"10.1016/j.clnesp.2024.09.017","url":null,"abstract":"<div><h3>Background &amp; aim</h3><div>Bioelectrical impedance analysis–derived phase angle (PhA) reflects the disruption of the cell membrane and intra- and extracellular fluid imbalances caused by chronic inflammation. This study examined the association between PhA and inflammatory markers in community-dwelling older adults.</div></div><div><h3>Methods</h3><div>A sex-stratified logistic regression analysis was conducted, with elevated C-reactive protein (CRP; ≥3.0 mg/L) and interleukin-6 (IL-6; &gt;4.0 pg/mL) levels as the outcomes and whole-body and local PhAs as the exposures. The same analysis was conducted with further stratification for age, overweight status, history of inflammation-related non-communicable diseases, and dietary inflammatory index. The ability to identify inflammation in whole-body and local PhAs was assessed using a receiver operating characteristic (ROC) curve.</div></div><div><h3>Results</h3><div>This study included 1664 participants (age: 76 [73–80] years; 855 women). In men, significant odds ratios (ORs) at the 95 % confidence interval (95 % CI) were observed for abnormal CRP and IL-6 levels for both whole-body and leg PhAs in the third quartile compared with the lowest quartile (OR [95 % CI] for abnormal CRP levels: 0.36 [0.18, 0.68] for whole-body PhA, 0.51 [0.27, 0.95] for leg PhA; OR [95 % CI] for abnormal IL-6 levels: 0.36 [0.15, 0.81] for whole-body PhA, 0.33 [0.12, 0.78] for leg PhA). The areas under the ROC curves (95 % CI) for identifying abnormal IL-6 were mild in men (0.62 [0.54, 0.70] for whole-body PhA and 0.62 [0.55, 0.70] for leg PhA). In men without a history of inflammation-related non-communicable diseases, it was 0.72 (0.59, 0.85) for whole-body PhA and 0.68 (0.54, 0.81) for leg PhA. In women, the PhA was not significantly associated with inflammatory markers.</div></div><div><h3>Conclusion</h3><div>PhA is associated with inflammation in community-dwelling older men, but may need to be combined with other information to identify inflammation.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low visceral fat volume and hypoalbuminemia as prognostic markers in hospitalized patients with coronavirus disease 2019 during the omicron variant epidemic","authors":"Shin Nakayama ,&nbsp;Yoshitaka Wakabayashi ,&nbsp;Kyotaro Kawase ,&nbsp;Ai Yamamoto ,&nbsp;Takatoshi Kitazawa","doi":"10.1016/j.clnesp.2024.09.016","DOIUrl":"10.1016/j.clnesp.2024.09.016","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>The rate of severe cases of coronavirus disease 2019 (COVID-19) has decreased since the Omicron variant became epidemic. Visceral fat volume was a risk factor for COVID-19 severity with prior prevalent variants, but whether visceral fat volume remains a risk factor for the Omicron variant is unclear. We investigated the associations of clinical factors including visceral fat volume with severity and mortality among hospitalized patients with COVID-19 during the Omicron variant epidemic.</div></div><div><h3>Methods</h3><div>This was a single-center retrospective cohort study conducted at the Teikyo University Hospital in Japan. We included hospitalized patients with COVID-19 during the Omicron variant epidemic who underwent computed tomography of the abdomen. Clinical data were obtained from the medical records and visceral fat area (VFA) was measured using a 3-dimensional image analysis system volume analyzer. Severity was determined by the presence or absence of oxygen supplementation.</div></div><div><h3>Results</h3><div>Among the 226 patients, 66 patients showed moderate severity and 29 patients were non-survivors. Hypoalbuminemia was associated with severity (odds ratio [OR] 3.93, 95 % confidence interval [CI] 1.91–8.07; p = 0.0002), and hypoalbuminemia (OR 8.38, 95%CI 2.37–29.58; p = 0.0010) and low VFA (OR 3.40, 95%CI 1.15–10.06; p = 0.027) were associated with mortality. Decision tree analysis showed that mortality rate in the hypoalbuminemia and low-VFA group (37.3 %) was significantly higher than in other groups (p ≤ 0.01).</div></div><div><h3>Conclusions</h3><div>Low visceral fat volume and hypoalbuminemia were associated with mortality in hospitalized patients with COVID-19 during the Omicron variant epidemic. Classification by VFA and serum albumin may allow simple prediction of mortality risk among hospitalized patients with COVID-19.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Vinegar (acetic acid) intake on glucose metabolism: A narrative review” [Clin Nutr ESPEN 32 (2019) 1–7]","authors":"Heitor O. Santos ,&nbsp;Wilson M.A.M. de Moraes ,&nbsp;Guilherme A.R. da Silva ,&nbsp;Jonato Prestes ,&nbsp;Brad J. Schoenfeld","doi":"10.1016/j.clnesp.2024.09.013","DOIUrl":"10.1016/j.clnesp.2024.09.013","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405457724013172/pdfft?md5=6616228ac80c053de419b4a3427dbc75&pid=1-s2.0-S2405457724013172-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BIA-assessed cellular hydration and strength in healthy older adults","authors":"Elena Vila ,&nbsp;Pedro Bezerra ,&nbsp;Bruno Silva ,&nbsp;José Mᵃ. Cancela","doi":"10.1016/j.clnesp.2024.09.010","DOIUrl":"10.1016/j.clnesp.2024.09.010","url":null,"abstract":"<div><h3>Objectives</h3><div>The objective of this research was to evaluate the differential relationships between various BIA-estimated compartments of body water and strength, among healthy older adults, by age range and sex.</div></div><div><h3>Design</h3><div>Descriptive and correlational study.</div></div><div><h3>Setting and participants</h3><div>A total of 234 healthy older adults (72.59 ± 7.60 years) participated in the study. Participants were recruited from community centers around Portugal and Spain. Data were recorded during May 2023. This is a physically active sample: all the participants are physically active for a minimum of three days a week.</div></div><div><h3>Methods</h3><div>For the study of body composition the variables extracted from the Tanita were: fat mass (FM), fat free mass (FFM), visceral fat rating (VFR), total body water (TBW), extracellular water (ECW) and intracellular water (ICW). Handgrip Strength was used to evaluate upper body strength and the Chair Stand Test for lower body strength.</div></div><div><h3>Results</h3><div>Differences across the various data sets were recorded in the gender variable.</div><div>When looking into the gender variable, significant correlations were recorded for the body composition variables analyzed for all age groups in the upper body strength test, except for BMI(r = .125–.878) and Fat mass (.056 to −.634). For the lower body strength test, no significant correlations were recorded for the Fat-Free mass variables (r = .164–.380), as well as for the Visceral Fat Rating(r = .082–.213) and the body water variables (TBW, ECW, ICW).</div></div><div><h3>Conclusions</h3><div>The hydration parameters analyzed can be related to muscle performance for Handgrip in an independent older adult population with ages ranging from 60 to 90 years.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro digestion study comparing a predigested glycerolysis product versus long-chain polyunsaturated fatty acid-rich oils (LCPUFA) as a strategy for administering LCPUFA to preterm neonates","authors":"Assamae Chabni ,&nbsp;Blanca Pardo de Donlebún ,&nbsp;Celia Bañares ,&nbsp;Carlos F. Torres","doi":"10.1016/j.clnesp.2024.09.011","DOIUrl":"10.1016/j.clnesp.2024.09.011","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Maintaining an adequate supply of arachidonic acid (ARA) and docosahexaenoic acid (DHA) is essential for optimal growth of preterm infants. This study aims to evaluate and compare the digestibility and bioaccessibility of ARA and DHA oils compared to their predigested product through an <em>in vitro</em> digestion model.</div></div><div><h3>Methods</h3><div>An <em>in vitro</em> gastrointestinal digestion model was used in two stages: gastric digestion and intestinal digestion. Samples of two polyunsaturated rich oils (ARA and DHA oils) and their predigested product (2:1, ARA: DHA) produced by enzymatic glycerolysis have been digested for 120 min. The final digestion product obtained was composed of three phases: an upper oily phase (OP) containing the undigested species, an intermediate micellar phase (MP) containing digested and bioaccessible lipids, and a precipitate phase (PP) with insoluble compounds. The reaction was monitored by taking aliquots and their subsequent lipid extraction and analysis.</div></div><div><h3>Results</h3><div>Poorer digestibility for ARA and DHA oils was observed based on the percentage of the oily phase (26.7% and 20%, respectively) found compared to the glycerolysis product (GP) oily phase (13.9%). The highest micellar phase was found in the GP (approx. 83%). On the other hand, the monoglyceride (MAG) content was lower in the digestion product (DP) from ARA and DHA oils, 4.3% and 9.2%, respectively, compared to the MAG observed in the DP of GP (15%).</div></div><div><h3>Conclusion</h3><div>Considering the percentage of oily phase, micellar phase, and the MAG content, it can be concluded that the GP is more digestible and ARA and DHA are more bioaccessible than in its precursor oils.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on: “An L-shaped relationship between dietary vitamin K and atherosclerotic cardiovascular disease”","authors":"Jinxiang Peng,&nbsp;Haozhu Chen","doi":"10.1016/j.clnesp.2024.09.012","DOIUrl":"10.1016/j.clnesp.2024.09.012","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-chamber parenteral nutrition (PN) bags are safe and cost-effective in replacing compounded PN regimens in hospitalised patients","authors":"Maja Kopczynska ,&nbsp;Simon Harrison ,&nbsp;Kirstine Farrer ,&nbsp;Gavin Leahy ,&nbsp;Charlotte Ollerenshaw-Ward ,&nbsp;Simon Lal","doi":"10.1016/j.clnesp.2024.09.009","DOIUrl":"10.1016/j.clnesp.2024.09.009","url":null,"abstract":"<div><h3>Background &amp; aims</h3><p>There is varied international practice in the use of ready-made multi-chamber bags (MCBs) and compounded parenteral nutrition (PN). Recent national aseptic pharmacy capacity limitations have restricted compounded PN production so we aimed to explore outcomes associated with the increased use of MCB vs compounded regimens during a period of change in PN supplies.</p></div><div><h3>Methods</h3><p>This was a point prevalence study conducted over two time periods, Period 1: 01.01.2022–31.03.2022 and Period 2: 01.10.2022–31.12.2022. Data were collected on PN regimen, outcomes, cost and aseptic time required to prepare PN bags.</p></div><div><h3>Results</h3><p>263 patients were included: 132 in Period 1 and 131 in Period 2. Overall, 2263 PN bags were utilised; 1179 in Period 1 and 1084 in Period 2. In Period 1, of all utilised bags, 138 (11.7%) were compounded PN, 356 (30.2%) supplemented MCBs and 685 (58.1%) manipulated MCBs whereas in Period 2, 0 were compounded PN, 546 (50.3%) supplemented MCBs and 538 (49.6%) manipulated MCBs. There were no significant differences in the proportion of patients with deranged blood tests between the study periods. In both periods there were only two episodes of catheter-related blood stream infection. The total cost saved in Period 2 compared to Period 1 was £20,684 and total aseptic staff time saved was 191 h.</p></div><div><h3>Conclusion</h3><p>Wider use of in-hospital MCB PN regimens could lead to a reduction in the need for compounded PN produced by aseptic pharmacy facilities, saving costs while maintaining good patient outcomes.</p></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}