Pub Date : 2025-02-01DOI: 10.1016/j.clnesp.2024.10.016
Run Wan ∗ , Zhou Juanjuan , Shang Yi , Zhou Xiaoqin
{"title":"Comparative Assessment of Skeletal Muscle Index and Sarcopenia in patients with Gastric cancer between Computed Tomography and Bioelectrical Impedance","authors":"Run Wan ∗ , Zhou Juanjuan , Shang Yi , Zhou Xiaoqin","doi":"10.1016/j.clnesp.2024.10.016","DOIUrl":"10.1016/j.clnesp.2024.10.016","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 494-495"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.clnesp.2024.10.040
Montserrat Tió , Josefina Fabian , Nuria Martin , Yocelin Saavedra , Elisabet Ripoll , Jenaro Fernandez-Valencia , Tomas Cuñat ∗
{"title":"Effect of high-dose dexamethasone in postoperative opioid use and perioperative glycaemia in FAST TRACK primary hip arthroplasty","authors":"Montserrat Tió , Josefina Fabian , Nuria Martin , Yocelin Saavedra , Elisabet Ripoll , Jenaro Fernandez-Valencia , Tomas Cuñat ∗","doi":"10.1016/j.clnesp.2024.10.040","DOIUrl":"10.1016/j.clnesp.2024.10.040","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 505-506"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143132167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.clnesp.2024.12.011
Mauricio Chona Chona , Lina Maria López Basto , Carolina Pinzón Ospina , Ana Cristina Pardo Coronado , María Paula Guzmán Silva , Marjorie Marín , Alvaro Vallejos , Gloria Esperanza Castro Osmán , Carlos Saavedra , Jorge Díaz Rojas , Jorge Medina-Parra , Ricardo Alfonso Merchán-Chaverra
Background and objectives
Surgical resection is a first-line treatment for patients with cancer, but preoperative malnutrition is a risk factor for postoperative complications. This study aimed to evaluate the association between preoperative administration of an immunonutrition regimen and postoperative clinical outcomes in patients with cancer undergoing major abdominal surgery.
Methods
The Surgical Prehabilitation Multimodal Oncology (SUPREMO) retrospective cohort study, conducted from January 2021 to December 2023, included patients with cancer undergoing major abdominal surgery. Patients were categorized based on whether they received a complete immunonutrition regimen or an incomplete or no regimen. Demographic and clinical data were extracted from electronic health records for descriptive analysis. Logistic regression was used to assess the impact of immunonutrition on the risk of infectious complications, with clinical and demographic variables as explanatory factors.
Results
A total of 620 patients were included, with 49 % receiving a complete preoperative immunonutrition regimen. Bivariate analysis indicated that complete regimen administration was associated with lower intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and vasopressor support requirements (p = 0.005, p = 0.019, and p = 0.032, respectively). The logistic regression model showed a significant reduction in in-hospital infectious complications (odds ratio 0.54, 95 % confidence interval 0.31–0.98; p = 0.044).
Conclusion
Administering a complete preoperative immunonutrition regimen may be associated with reduced infectious complications, ICU and IMV requirements, and vasopressor support use.
{"title":"Preoperative immunonutrition and postoperative outcomes in patients with cancer undergoing major abdominal surgery: Retrospective cohort study","authors":"Mauricio Chona Chona , Lina Maria López Basto , Carolina Pinzón Ospina , Ana Cristina Pardo Coronado , María Paula Guzmán Silva , Marjorie Marín , Alvaro Vallejos , Gloria Esperanza Castro Osmán , Carlos Saavedra , Jorge Díaz Rojas , Jorge Medina-Parra , Ricardo Alfonso Merchán-Chaverra","doi":"10.1016/j.clnesp.2024.12.011","DOIUrl":"10.1016/j.clnesp.2024.12.011","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Surgical resection is a first-line treatment for patients with cancer, but preoperative malnutrition is a risk factor for postoperative complications. This study aimed to evaluate the association between preoperative administration of an immunonutrition regimen and postoperative clinical outcomes in patients with cancer undergoing major abdominal surgery.</div></div><div><h3>Methods</h3><div>The Surgical Prehabilitation Multimodal Oncology (SUPREMO) retrospective cohort study, conducted from January 2021 to December 2023, included patients with cancer undergoing major abdominal surgery. Patients were categorized based on whether they received a complete immunonutrition regimen or an incomplete or no regimen. Demographic and clinical data were extracted from electronic health records for descriptive analysis. Logistic regression was used to assess the impact of immunonutrition on the risk of infectious complications, with clinical and demographic variables as explanatory factors.</div></div><div><h3>Results</h3><div>A total of 620 patients were included, with 49 % receiving a complete preoperative immunonutrition regimen. Bivariate analysis indicated that complete regimen administration was associated with lower intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and vasopressor support requirements (<em>p</em> = 0.005, <em>p</em> = 0.019, and <em>p</em> = 0.032, respectively). The logistic regression model showed a significant reduction in in-hospital infectious complications (odds ratio 0.54, 95 % confidence interval 0.31–0.98; <em>p</em> = 0.044).</div></div><div><h3>Conclusion</h3><div>Administering a complete preoperative immunonutrition regimen may be associated with reduced infectious complications, ICU and IMV requirements, and vasopressor support use.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 324-330"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.clnesp.2024.12.020
Rafaela Rodrigues Vieira , Patrícia Zamberlan
Background
Nutritional intervention during hospitalisation is vital in managing of children and adolescents in intensive care. In this context, body composition measurements, such as mid-upper arm circumference (MUAC), can help improve the accuracy of nutritional assessments. However, using MUAC has some limitations. Calf circumference (CC) is a straightforward, inexpensive, and easily obtainable measurement. However, no reference values currently exist for CC in paediatric patients.
Aims
To describe the nutritional monitoring of critically ill children and adolescents in the Paediatric Intensive Care Unit (PICU) using CC.
Methods
Patients aged 6 months to 18 years old who were admitted to the PICUs participated in the study. Two MUAC and CC measurements were performed: one in the first 48 h of admission to the PICU and another after 7 days. The percentage change between the two measurements was compared. Information was also evaluated about demographic and outcome data. Analyses were conducted with all patients included in the sample collectively and subdivided by age (<10 years and ≥10 years).
Results
Two hundred and eleven patients underwent anthropometric assessment on admission, and the sample for comparative analyses consisted of 103 patients (after discharges and deaths). MUAC and CC significantly decreased in the first week of hospitalisation. A positive weak correlation was found between the percentage change in the MUAC and CC only for individuals under 10 years old and for the total sample, but not for adolescents. The all age group and children under 10 years old showed a greater reduction in CC than in MUAC. The same did not occur for adolescents.
Conclusions
Calf circumference may be a promising method for nutritional monitoring of critically ill children in Paediatric Intensive Care Units because it can indicate signs of depletion earlier than mid-upper arm circumference. These results are more meaningful for children than for adolescents.
{"title":"Calf circumference may complement the nutritional assessment of children under 10 in the paediatric intensive care unit","authors":"Rafaela Rodrigues Vieira , Patrícia Zamberlan","doi":"10.1016/j.clnesp.2024.12.020","DOIUrl":"10.1016/j.clnesp.2024.12.020","url":null,"abstract":"<div><h3>Background</h3><div>Nutritional intervention during hospitalisation is vital in managing of children and adolescents in intensive care. In this context, body composition measurements, such as mid-upper arm circumference (MUAC), can help improve the accuracy of nutritional assessments. However, using MUAC has some limitations. Calf circumference (CC) is a straightforward, inexpensive, and easily obtainable measurement. However, no reference values currently exist for CC in paediatric patients.</div></div><div><h3>Aims</h3><div>To describe the nutritional monitoring of critically ill children and adolescents in the Paediatric Intensive Care Unit (PICU) using CC.</div></div><div><h3>Methods</h3><div>Patients aged 6 months to 18 years old who were admitted to the PICUs participated in the study. Two MUAC and CC measurements were performed: one in the first 48 h of admission to the PICU and another after 7 days. The percentage change between the two measurements was compared. Information was also evaluated about demographic and outcome data. Analyses were conducted with all patients included in the sample collectively and subdivided by age (<10 years and ≥10 years).</div></div><div><h3>Results</h3><div>Two hundred and eleven patients underwent anthropometric assessment on admission, and the sample for comparative analyses consisted of 103 patients (after discharges and deaths). MUAC and CC significantly decreased in the first week of hospitalisation. A positive weak correlation was found between the percentage change in the MUAC and CC only for individuals under 10 years old and for the total sample, but not for adolescents. The all age group and children under 10 years old showed a greater reduction in CC than in MUAC. The same did not occur for adolescents.</div></div><div><h3>Conclusions</h3><div>Calf circumference may be a promising method for nutritional monitoring of critically ill children in Paediatric Intensive Care Units because it can indicate signs of depletion earlier than mid-upper arm circumference. These results are more meaningful for children than for adolescents.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 445-452"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.clnesp.2024.10.043
Thilo Welsch ∗, Alina Ritter, Freya Brodersen, Tobias Schneider, Faik Güntac Uzunoglu, Felix Nickel, Mara R. Goetz, Jana Bardenhagen, Thilo Hackert, Jakob R. Izbicki
{"title":"Impact Of Enhanced Recovery After Surgery Protocol Compliance On Outcome After Pancreatic Surgery – Results From A Certified Eras Center","authors":"Thilo Welsch ∗, Alina Ritter, Freya Brodersen, Tobias Schneider, Faik Güntac Uzunoglu, Felix Nickel, Mara R. Goetz, Jana Bardenhagen, Thilo Hackert, Jakob R. Izbicki","doi":"10.1016/j.clnesp.2024.10.043","DOIUrl":"10.1016/j.clnesp.2024.10.043","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Page 507"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.clnesp.2024.11.002
Lara J. Bou Malhab , Mohamed I. Madkour , Dana N. Abdelrahim , Leen Eldohaji , Maha Saber-Ayad , Nabil Eid , Wael M. Abdel-Rahman , MoezAlIslam E. Faris
Aim and background
A growing body of evidence supports the impact of intermittent fasting (IF) on longevity and healthy aging via the modulation of autophagy genes. The activation of the catabolic autophagic machinery (LAMP2, LC3B, ATG5, and ATG4D) has protective effects against degenerative aging and chronic diseases. This research examined the changes in the expression of the aforementioned genes upon the observance of dawn-to-dusk IF among metabolically healthy participants with overweight and obesity.
Methods
Fifty-one (51) participants (36 males and 15 females, 38.84 ± 11.73 years) with overweight and obesity (BMI = 29.75 ± 5.04 kg/m2) were recruited and monitored before and at the end of the commencement of the four-week IF. Six healthy subjects with normal BMI (21.4 ± 2.20 kg/m2) were recruited only to standardize the reference for normal levels of gene expressions. At the two time points, anthropometric, biochemical, and dietary assessments were performed, and LAMP2, LC3B, ATG5, and ATG4D gene expressions were assessed using qRT-PCR on RNA extracted from whole blood samples.
Results
At the end of IF, and compared to the pre-fasting levels, the relative gene expressions among participants with overweight/obesity were significantly increased for the three autophagy genes LAMP2, LC3B, and ATG5, with increments of about 4.2 folds, 1.9-fold, and 1.4-fold, respectively. In contrast, the increase in the ATG4D gene was not significant. Concomitantly, significant decreases were found in body weight, BMI, fat mass, body fat percent, hip and waist circumferences, LDL, IL-6, and TNF-a (P < 0.05), While HDL, IL-10, and CD163 significantly increased (P < 0.05). Binary logistic regression analysis for genetic expressions showed no significant association between high-energy intake, waist circumference, or obesity and the four gene expressions.
Conclusions
Four consecutive weeks of dawn-to-dusk IF of Ramadan is associated with the upregulation of autophagy gene expressions in participants with overweight/obesity, and this may explain, at least in part, its favorable short-term temporal metabolic and health-improving effects on early aging-related markers. Hence, IF presumably may entail a protective impact against early markers of aging and metabolic diseases in participants with overweight/obesity.
{"title":"Dawn-to-dusk intermittent fasting is associated with overexpression of autophagy genes: A prospective study on overweight and obese cohort","authors":"Lara J. Bou Malhab , Mohamed I. Madkour , Dana N. Abdelrahim , Leen Eldohaji , Maha Saber-Ayad , Nabil Eid , Wael M. Abdel-Rahman , MoezAlIslam E. Faris","doi":"10.1016/j.clnesp.2024.11.002","DOIUrl":"10.1016/j.clnesp.2024.11.002","url":null,"abstract":"<div><h3>Aim and background</h3><div>A growing body of evidence supports the impact of intermittent fasting (IF) on longevity and healthy aging via the modulation of autophagy genes. The activation of the catabolic autophagic machinery (<em>LAMP2, LC3B, ATG5</em>, and <em>ATG4D)</em> has protective effects against degenerative aging and chronic diseases. This research examined the changes in the expression of the aforementioned genes upon the observance of dawn-to-dusk IF among metabolically healthy participants with overweight and obesity.</div></div><div><h3>Methods</h3><div>Fifty-one (51) participants (36 males and 15 females, 38.84 ± 11.73 years) with overweight and obesity (BMI = 29.75 ± 5.04 kg/m<sup>2</sup>) were recruited and monitored before and at the end of the commencement of the four-week IF. Six healthy subjects with normal BMI (21.4 ± 2.20 kg/m<sup>2</sup>) were recruited only to standardize the reference for normal levels of gene expressions. At the two time points, anthropometric, biochemical, and dietary assessments were performed, and <em>LAMP2, LC3B, ATG5</em>, and <em>ATG4D</em> gene expressions were assessed using qRT-PCR on RNA extracted from whole blood samples.</div></div><div><h3>Results</h3><div>At the end of IF, and compared to the pre-fasting levels, the relative gene expressions among participants with overweight/obesity were significantly increased for the three autophagy genes <em>LAMP2</em>, <em>LC3B,</em> and <em>ATG5</em>, with increments of about 4.2 folds, 1.9-fold, and 1.4-fold, respectively. In contrast, the increase in the <em>ATG4D</em> gene was not significant. Concomitantly, significant decreases were found in body weight, BMI, fat mass, body fat percent, hip and waist circumferences, LDL, IL-6, and TNF-a (<em>P</em> < <em>0.05</em>), While HDL, IL-10, and CD163 significantly increased (<em>P</em> < <em>0.05</em>). Binary logistic regression analysis for genetic expressions showed no significant association between high-energy intake, waist circumference, or obesity and the four gene expressions.</div></div><div><h3>Conclusions</h3><div>Four consecutive weeks of dawn-to-dusk IF of Ramadan is associated with the upregulation of autophagy gene expressions in participants with overweight/obesity, and this may explain, at least in part, its favorable short-term temporal metabolic and health-improving effects on early aging-related markers. Hence, IF presumably may entail a protective impact against early markers of aging and metabolic diseases in participants with overweight/obesity.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 209-217"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.clnesp.2024.11.026
Tatiana Palotta Minari , Carolina Freitas Manzano , Louise Buonalumi Tácito Yugar , Luis Gustavo Sedenho-Prado , Tatiane de Azevedo Rubio , Lúcia Helena Bonalumi Tácito , Antônio Carlos Pires , José Fernando Vilela-Martin , Luciana Neves Cosenso-Martin , Nelson Dinamarco Ludovico , André Fattori , Juan Carlos Yugar-Toledo , Heitor Moreno , Luciana Pellegrini Pisani
Background & aims
Meal timing is an emerging branch of science that investigates the influence of eating patterns on the circadian rhythm and overall health. There are still discrepancies in the literature as to whether late distribution of food intake and sleep disorders could impact biochemical, anthropometric, and cardiovascular markers. The objectives of this study were firstly observe skipping breakfast and sleep disorders over 12 months. Secondarily, analyze the individual influence of these findings on changes biochemical, anthropometric, and cardiovascular markers during the same period.
Methods
This descriptive study is part of a tertiary analysis in a recently published study. This research recruited 84 participants with Type 2 Diabetes (T2D) who were divided: Control-40 participants received only medical care; Intervention-44 participants received the same medical care along with nutritional assessment. Consultations occurred quarterly over 12th months, and a follow-up was conducted after 3 months. For influence analysis, non-normal variables were compared using Mann–Whitney, while normal variables were compared using unpaired t-tests. In all instances, α = 0.05 and P < 0.05 were adopted.
Results
Analysis revealed a high percentage of patients in both groups who skipped breakfast, slept less than 6 h, and experienced nighttime awakenings during the 1st visit. By the 12th month, there was deterioration in all data in the control group and significant improvement in the intervention group. Those with sleep disturbances also had lower HDL-cholesterol (HDL-C) values (p = 0.0054). For the other analyzes no significant differences were found.
Conclusion
Participants who skipped breakfast and had more nocturnal awakenings possibly had worse glycemic and weight control, but this difference was not statistically significant and only trends were observed. Sleep disorders could affect HDL-C levels. However, the influence analysis does not establish a causal relationship and more clinical trials are needed to analyze this topic on T2D.
背景与目的：进餐时间是研究饮食模式对昼夜节律和整体健康影响的一个新兴科学分支。关于食物摄入和睡眠障碍的晚分布是否会影响生物化学、人体测量学和心血管指标，文献中仍然存在差异。本研究的目的首先是在12个月内观察不吃早餐和睡眠障碍。其次，分析这些发现在同一时期对生化、人体测量和心血管指标变化的个体影响。方法：该描述性研究是最近发表的一项研究的三级分析的一部分。这项研究招募了84名2型糖尿病患者（T2D），他们被分为两组：对照组40人只接受医疗护理；干预44的参与者在接受营养评估的同时也接受了同样的医疗护理。在12个月内每季度进行一次咨询，3个月后进行随访。对于影响分析，使用Mann-Whitney比较非正态变量，而使用非配对t检验比较正态变量。各试验均采用α = 0.05, P < 0.05。结果：分析显示，两组患者在第一次就诊时不吃早餐、睡眠时间少于6小时、夜间醒来的比例都很高。到第12个月时，对照组所有数据均出现恶化，干预组有明显改善。睡眠障碍患者的高密度脂蛋白胆固醇（HDL-C）值也较低（p=0.0054）。对于其他分析，没有发现显著差异。结论：不吃早餐和夜间醒来较多的参与者可能血糖和体重控制较差，但这种差异没有统计学意义，只观察到趋势。睡眠障碍会影响HDL-C水平。然而，影响分析并没有建立因果关系，需要更多的临床试验来分析T2D的这一主题。
{"title":"The effect of breakfast skipping and sleep disorders on glycemic control, cardiovascular risk, and weight loss in type 2 diabetes","authors":"Tatiana Palotta Minari , Carolina Freitas Manzano , Louise Buonalumi Tácito Yugar , Luis Gustavo Sedenho-Prado , Tatiane de Azevedo Rubio , Lúcia Helena Bonalumi Tácito , Antônio Carlos Pires , José Fernando Vilela-Martin , Luciana Neves Cosenso-Martin , Nelson Dinamarco Ludovico , André Fattori , Juan Carlos Yugar-Toledo , Heitor Moreno , Luciana Pellegrini Pisani","doi":"10.1016/j.clnesp.2024.11.026","DOIUrl":"10.1016/j.clnesp.2024.11.026","url":null,"abstract":"<div><h3>Background & aims</h3><div>Meal timing is an emerging branch of science that investigates the influence of eating patterns on the circadian rhythm and overall health. There are still discrepancies in the literature as to whether late distribution of food intake and sleep disorders could impact biochemical, anthropometric, and cardiovascular markers<strong>.</strong> The objectives of this study were firstly observe skipping breakfast and sleep disorders over 12 months. Secondarily, analyze the individual influence of these findings on changes biochemical, anthropometric, and cardiovascular markers during the same period.</div></div><div><h3>Methods</h3><div>This descriptive study is part of a tertiary analysis in a recently published study. This research recruited 84 participants with Type 2 Diabetes (T2D) who were divided: Control-40 participants received only medical care; Intervention-44 participants received the same medical care along with nutritional assessment. Consultations occurred quarterly over 12th months, and a follow-up was conducted after 3 months. For influence analysis, non-normal variables were compared using Mann–Whitney, while normal variables were compared using unpaired t-tests. In all instances, α = 0.05 and P < 0.05 were adopted.</div></div><div><h3>Results</h3><div>Analysis revealed a high percentage of patients in both groups who skipped breakfast, slept less than 6 h, and experienced nighttime awakenings during the 1st visit. By the 12th month, there was deterioration in all data in the control group and significant improvement in the intervention group. Those with sleep disturbances also had lower HDL-cholesterol (HDL-C) values (p = 0.0054). For the other analyzes no significant differences were found.</div></div><div><h3>Conclusion</h3><div>Participants who skipped breakfast and had more nocturnal awakenings possibly had worse glycemic and weight control, but this difference was not statistically significant and only trends were observed. Sleep disorders could affect HDL-C levels. However, the influence analysis does not establish a causal relationship and more clinical trials are needed to analyze this topic on T2D.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 172-181"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.clnesp.2024.10.013
Gregg Nelson ∗ , Abby Thomas , Steven P. Bisch , Hans D. de Boer , Martin Hubner , Khara Sauro
{"title":"Comparison of International Enhanced Recovery After Surgery (ERAS) Outcomes: An ERAS Interactive Audit System (EIAS) Database Study","authors":"Gregg Nelson ∗ , Abby Thomas , Steven P. Bisch , Hans D. de Boer , Martin Hubner , Khara Sauro","doi":"10.1016/j.clnesp.2024.10.013","DOIUrl":"10.1016/j.clnesp.2024.10.013","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Page 493"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.clnesp.2024.12.009
Tülay Tiftik , Murat Kara , Cevriye Mülkoğlu , İrem Çiftçi , Ömer Faruk Çelik , Mahmut Esad Durmuş , Özgür Kara , Şerife Mehlika Kuşkonmaz , Hakan Genç , Bayram Kaymak , Levent Özçakar
Introduction
Type 2 diabetes mellitus (DM), osteoporosis (OP) and sarcopenia are major public health problems related with higher fall/fracture risks, morbidity and mortality. Due to the lack of a comprehensive analysis among OP, sarcopenia and DM; we aimed to explore the relationships between DM and the aforementioned conditions in postmenopausal women.
Methods
This cross-sectional study included postmenopausal women who consecutively admitted to the Departments of Physical & Rehabilitation Medicine, and Endocrinology and Metabolism. Demographic data, nutrition/cognition status and frailty scores of the participants were recorded. Sarcopenia-related parameters including, anterior thigh muscle thickness, handgrip strength, chair stand test, gait speed, and one-leg stand test (OLST) were measured. ISarcoPRM algorithm was used for the diagnosis of sarcopenia.
Results
A total of 444 postmenopausal women were consecutively enrolled. DM patients (N = 158) had higher frequency of sarcopenia (23.4 % vs. 12.9 %), but lower frequency of OP (33.5 % vs. 50.7 %) than controls (both p < 0.01). As regards regression analyses; menopause duration was positively (OR: 1.054, 95 % CI 1.030–1.077), but weight (OR: 0.957, 95 % CI 0.940–0.975) and DM (OR: 0.477, 95 % CI 0.310–0.733) were negatively related with OP (all p < 0.001). On the other hand, age (OR: 1.094, 95 % CI 1.056–1.133), body mass index (OR: 1.131, 95 % CI 1.067–1.198), and DM (OR: 1.887, 95 % CI 1.107–3.218) were positively related with sarcopenia (all p < 0.05). In addition, age (β = −0.355, p < 0.001), body mass index (β = −0.108, p = 0.021) and DM (β = −0.209, p < 0.001) were negatively related with OLST values.
Conclusion
DM has paradoxical associations with bone mass and muscle mass/function. Although it has negative relationship with OP (about two times lower odds), it has positive relationship with sarcopenia (about two times higher odds).
导言：2型糖尿病（DM）、骨质疏松症（OP）和肌肉疏松症是与较高的跌倒/骨折风险、发病率和死亡率相关的主要公共健康问题。由于缺乏对骨质疏松症、肌肉疏松症和糖尿病之间关系的全面分析，我们旨在探讨绝经后女性糖尿病与上述疾病之间的关系：这项横断面研究包括连续在物理与康复医学科、内分泌与代谢科住院的绝经后妇女。研究人员记录了参与者的人口统计学数据、营养/认知状况和虚弱评分。测量了与 "肌肉疏松症 "相关的参数，包括大腿前侧肌肉厚度、手握力、椅子站立测试、步速和单腿站立测试（OLST）。采用 ISarcoPRM 算法诊断肌肉疏松症：结果：共有 444 名绝经后妇女连续入选。与对照组相比，DM 患者（158 人）出现肌少症的频率较高（23.4% 对 12.9%），但出现 OP 的频率较低（33.5% 对 50.7%）：DM与骨量和肌肉质量/功能的关系自相矛盾。虽然它与 OP 呈负相关（几率低约两倍），但与肌肉疏松症呈正相关（几率高约两倍）。
{"title":"The Paradoxical Relationship Among Diabetes Mellitus, Osteoporosis and Sarcopenia: The PARADOS Study","authors":"Tülay Tiftik , Murat Kara , Cevriye Mülkoğlu , İrem Çiftçi , Ömer Faruk Çelik , Mahmut Esad Durmuş , Özgür Kara , Şerife Mehlika Kuşkonmaz , Hakan Genç , Bayram Kaymak , Levent Özçakar","doi":"10.1016/j.clnesp.2024.12.009","DOIUrl":"10.1016/j.clnesp.2024.12.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Type 2 diabetes mellitus (DM), osteoporosis (OP) and sarcopenia are major public health problems related with higher fall/fracture risks, morbidity and mortality. Due to the lack of a comprehensive analysis among OP, sarcopenia and DM; we aimed to explore the relationships between DM and the aforementioned conditions in postmenopausal women.</div></div><div><h3>Methods</h3><div>This cross-sectional study included postmenopausal women who consecutively admitted to the Departments of Physical & Rehabilitation Medicine, and Endocrinology and Metabolism. Demographic data, nutrition/cognition status and frailty scores of the participants were recorded. Sarcopenia-related parameters including, anterior thigh muscle thickness, handgrip strength, chair stand test, gait speed, and one-leg stand test (OLST) were measured. ISarcoPRM algorithm was used for the diagnosis of sarcopenia.</div></div><div><h3>Results</h3><div>A total of 444 postmenopausal women were consecutively enrolled. DM patients (<em>N</em> = 158) had higher frequency of sarcopenia (23.4 % vs. 12.9 %), but lower frequency of OP (33.5 % vs. 50.7 %) than controls (both <em>p</em> < 0.01). As regards regression analyses; menopause duration was positively (OR: 1.054, 95 % CI 1.030–1.077), but weight (OR: 0.957, 95 % CI 0.940–0.975) and DM (OR: 0.477, 95 % CI 0.310–0.733) were negatively related with OP (all <em>p</em> < 0.001). On the other hand, age (OR: 1.094, 95 % CI 1.056–1.133), body mass index (OR: 1.131, 95 % CI 1.067–1.198), and DM (OR: 1.887, 95 % CI 1.107–3.218) were positively related with sarcopenia (all <em>p</em> < 0.05). In addition, age (β = −0.355, <em>p</em> < 0.001), body mass index (β = −0.108, <em>p</em> = 0.021) and DM (β = −0.209, <em>p</em> < 0.001) were negatively related with OLST values.</div></div><div><h3>Conclusion</h3><div>DM has paradoxical associations with bone mass and muscle mass/function. Although it has negative relationship with OP (about two times lower odds), it has positive relationship with sarcopenia (about two times higher odds).</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 258-263"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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