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Ethics of reversible dermatologic care in transgender and gender-diverse adolescents under restrictive and ambiguous laws 在限制和模糊的法律下,变性和性别多样化(TGD)青少年的可逆皮肤护理伦理。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 Epub Date: 2025-02-20 DOI: 10.1016/j.clindermatol.2025.02.010
Priya Patel Housley MS , Sami K. Saikaly MD , Neelesh Jain MD , Jane M. Grant-Kels MD
Gender dysphoria causes significant distress in transgender and gender-diverse (TGD) adolescents, often impacting their mental health. Evidence-based gender-affirming interventions, such as hormone therapy, have been shown to reduce this distress and lower suicide risk, and dermatological treatments may help alleviate gender dysphoria. However, recent state-specific legal restrictions and ambiguous laws in the United States (US) have created barriers for TGD adolescents from accessing these treatments; some states have passed new laws that restrict TGD youth access to surgical and even medical gender affirming services as hormone treatment. We explore dermatologists’ challenges in providing care to TGD adolescents in legally ambiguous and restrictive states in the context of the core ethical principles of autonomy, beneficence, nonmaleficence, and justice. Using exemplary case studies, we discuss ethical dilemmas involving dermal fillers, laser hair removal, hair growth treatments, and acne management for TGD adolescents living in such states. We find that as such treatments are available in other geographic locations, available for cis-gender individuals and not necessarily permanent, there is a violation of the core principle of justice. Dermatologists should navigate these legal and ethical complexities to provide safe, compassionate care for TGD adolescents. Advocacy for clear state-specific guidelines, equitable access to care, and ongoing research are essential to support this vulnerable population.
性别焦虑症对跨性别和性别多样化青少年造成严重困扰,往往影响他们的心理健康。以证据为基础的性别肯定干预措施,如激素治疗,已被证明可以减少这种痛苦并降低自杀风险,皮肤病治疗可能有助于减轻性别不安;然而,美国最近各州的具体法律限制和模棱两可的法律为TGD青少年获得这些治疗创造了障碍。我们探讨皮肤科医生的挑战,在自主、慈善、无害和正义的核心伦理原则的背景下,在法律上模棱两可和限制性的状态下,为TGD青少年提供护理。通过典型案例研究,我们讨论了涉及真皮填充物、激光脱毛、毛发生长治疗以及生活在这种状态下的TGD青少年的痤疮管理的伦理困境。我们发现,由于这种治疗在其他地理位置也有,对顺性人也有,而且不一定是永久性的,这违反了正义的核心原则。皮肤科医生必须驾驭这些法律和伦理的复杂性,为TGD青少年提供安全、富有同情心的护理。倡导明确的各州具体指导方针、公平获得医疗服务和正在进行的研究对于支持这一弱势群体至关重要。
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引用次数: 0
Red marble and the art for peace: An example from the Great Northern Wars (1700-1772). 红色大理石与和平艺术。以北方大战争(1700-1772)为例。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-10-28 DOI: 10.1016/j.clindermatol.2025.10.007
Uwe Wollina, Andreas Nowak, Leonard J Hoenig, Lawrence Charles Parish

Red marble is a rare limestone found in the Ore Mountains of Saxony, Germany. It was used by a court goldsmith, Johann Heinrich Köhler (1669-1736), to create a sculpture for King Augustus the Strong (1670-1733) and for his widely known Green Vault in the Royal Palace of Dresden. This treasured small figure of a disabled Swedish Grenadier depicts the bloody experience of the battlefield during the Great Northern War (1700-1721) in the German States. The grenadier sculpture also conveys a positive message to the viewer, intended to guide the prevention of death and suffering-an art object for peace.

红色大理石是一种罕见的石灰石,发现于德国萨克森州的矿石山脉。它曾被宫廷金匠约翰·海因里希Köhler(1669-1736)用来为国王奥古斯都(1670-1733)和他在德累斯顿皇宫中著名的绿色穹顶制作雕塑。这个珍贵的残疾瑞典掷弹兵的小雕像描绘了大北方战争(1700-1721)期间德国战场上的血腥经历。掷弹兵雕塑也向观众传达了积极的信息,旨在指导防止死亡和痛苦-和平的艺术对象。
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引用次数: 0
Clinical and ethical considerations in nanotechnology-based dermatologic care. 基于纳米技术的皮肤护理的临床和伦理考虑。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-10-16 DOI: 10.1016/j.clindermatol.2025.10.004
Isabella J Tan, Tarek Zieneldien, Sophia Ma, Jane M Grant-Kels

Nanodermatology is the application of nanotechnology specifically to dermatology. We discuss the pros and cons of translating these innovations into routine dermatology practice, as well as the unique safety challenges, regulatory issues, and ethical and equity concerns surrounding nanodermatology. Unlike other emerging technologies, nanodermatology involves transcutaneous exposure to engineered nanoparticles that may penetrate beyond the epidermis, persist in tissues, and accumulate systemically. These characteristics create distinct safety and ethical challenges, including invisible patient exposure, uncertain long-term toxicologic effects, and unequal regulatory oversight across countries. The specific ethical issues involve nonmaleficence, informed consent, privacy, autonomy, and justice.

纳米皮肤病学是纳米技术专门应用于皮肤病学。我们讨论了将这些创新转化为常规皮肤医学实践的利弊,以及围绕纳米皮肤医学的独特安全挑战、监管问题以及伦理和公平问题。与其他新兴技术不同,纳米皮肤病学涉及经皮暴露于工程纳米颗粒,这些纳米颗粒可能穿透表皮,持续存在于组织中,并在全身积累。这些特点带来了明显的安全和伦理挑战,包括看不见的患者暴露、不确定的长期毒理学效应以及各国监管监督的不平等。具体的伦理问题包括非恶意、知情同意、隐私、自主和正义。纳米技术正在成为皮肤病学的关键前沿,其应用范围从靶向药物递送到纳米级诊断传感器和先进的化妆品配方例如,基于纳米颗粒的外用制剂可增加免疫调节剂进入银屑病斑块的递送,用于增强他克莫司角质层渗透的胶束载体,以及能够实时检测炎症生物标志物的纳米传感器最近的研究强调纳米皮肤病学,将纳米技术专门应用于皮肤病学,作为解决持续挑战的潜在解决方案,如提高治疗效果,减少全身毒性,以及实现精确的皮肤病学干预将这些创新转化为日常实践引发了关键的伦理、安全和公平问题。
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引用次数: 0
The ethical implications of financial burdens incurred by medical students to attend dermatology conferences. 医学生参加皮肤科会议所产生的经济负担的伦理含义。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.clindermatol.2025.09.018
Eunheh Koh, Joo Young Jung, Loretta S Davis

As the dermatology residency match has become increasingly competitive, dermatology applicants are more prolific in their research achievements, including numerous poster presentations, abstracts, and manuscripts. Notably, students often feel compelled to attend as many conferences as possible to showcase their scholarly work and demonstrate their interest in the specialty. Compared with other research deliverables, conference attendance also offers the valuable benefit of networking opportunities. Attending conferences can impose a significant financial burden on students; the cumulative cost of accommodations, registration, and travel for multiple meetings can quickly become burdensome. The ethical considerations of this financial commitment and its implications on the dermatology applicant pool must be recognized as a consequence of the competitive residency application process.

随着皮肤科住院医师的竞争越来越激烈,皮肤科申请者的研究成果越来越多,包括大量的海报展示、摘要和手稿。值得注意的是,学生们经常感到有必要参加尽可能多的会议,以展示他们的学术工作和展示他们对该专业的兴趣。与其他研究成果相比,参加会议也提供了宝贵的社交机会。参加会议可能会给学生带来沉重的经济负担;多次会议的住宿、注册和旅行的累积成本可能很快就会成为负担。这种财务承诺的伦理考虑及其对皮肤科申请人池的影响必须被认为是竞争的住院医师申请过程的结果。
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引用次数: 0
Contextualizing the Clinic: A Model for History and Ethics Curricula in Graduate Medical Education. 诊所情境化:研究生医学教育中历史与伦理学课程的模式。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-29 DOI: 10.1016/j.clindermatol.2025.09.016
Sana Kamboj, Saad Maan, Hala Idris, Ameya Gangal, Travis W Blalock

The Accreditation Council of Graduate Medical Education (ACGME) requires ethics education for dermatology trainees; yet, less than half of American dermatology residencies currently include ethics in their curriculum. 1, 2 Barriers to establishing ethics curricula in dermatology residences include time restraints, lack of useful resources, and lack of faculty with expertise in dermatoethics.2 We suggest a hybrid education model, involving a mix of virtual, lecture-based, and case-based didactics to incorporate ethics education longitudinally in dermatology residencies. Subject matter should align with the American Academy of Dermatology subcommittee's six domains of ethics education.

研究生医学教育认证委员会(ACGME)要求对皮肤科学员进行道德教育;然而,目前只有不到一半的美国皮肤科住院医师将伦理学纳入他们的课程。1,2在皮肤科住院医师中建立伦理学课程的障碍包括时间限制,缺乏有用的资源,以及缺乏具有皮肤伦理学专业知识的教师我们建议采用一种混合教育模式,包括虚拟教学、以讲座为基础的教学和以案例为基础的教学,将皮肤科住院医师的伦理教育纵向纳入其中。主题应与美国皮肤病学会小组委员会的六个道德教育领域保持一致。
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引用次数: 0
Natura sanat-nature heals-Dr Heinrich Lahmann and his physiatric sanatorium. 自然疗养院-自然治疗-海因里希·拉赫曼博士和他的理疗疗养院。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-27 DOI: 10.1016/j.clindermatol.2025.09.015
Uwe Wollina, Leonard J Hoenig, Lawrence Charles Parish

Dr Heinrich Lahmann was a German physician and health reformer who was especially active in Dresden and the surrounding area during the first half of the 20th century. He was born on December 11, 1860, in Bremen and died in Dresden in 1941. Lahmann was especially well-known for his efforts to improve general health care, promote naturopathy, and his role as a sanatorium director. His work and the institutions he established had a far-reaching impact on the medical landscape of his time. His sanatorium attracted patients from Europe and beyond, where he also tried to apply his therapeutic approach to sexually transmitted diseases and chronic dermatitis.

海因里希·拉赫曼博士是一位德国医生和健康改革者,他在20世纪上半叶在德累斯顿和周边地区特别活跃。他于1860年12月11日出生在不来梅,1941年在德累斯顿去世。拉赫曼尤其以他改善一般医疗保健、促进自然疗法的努力和他作为疗养院主任的角色而闻名。他的工作和他建立的机构对他那个时代的医学景观产生了深远的影响。他的疗养院吸引了来自欧洲和其他地区的病人,在那里他还试图将他的治疗方法应用于性传播疾病和慢性皮炎。
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引用次数: 0
Prurigo nodularis and acquired perforating dermatosis in chronic kidney disease: Are they the same entity? 慢性肾脏疾病的结节性痒疹和获得性穿孔性皮肤病:它们是同一个实体吗?
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 Epub Date: 2025-03-15 DOI: 10.1016/j.clindermatol.2025.03.011
Rami H. Mahmoud BS , Giulia Coscarella MD , Ruby Kwak MD , Gil Yosipovitch MD
Prurigo nodularis has been reported in itchy chronic kidney disease (CKD) patients, particularly those with end-stage renal failure. Acquired perforating dermatitis associated with CKD and diabetes is a group of disorders in which dermal materials are eliminated through the epidermis and is characterized by itchy papules and nodules. We focus on the relationship between prurigo nodularis and acquired perforating dermatitis in CKD and provide data to support that both entities share many of the same clinical and histologic features. These cutaneous diseases are often underreported in this patient population, leading to inadequate treatment and suboptimal patient outcomes. Our review of the literature suggests a relationship between prurigo nodularis/acquired perforating dermatitis and CKD, presumably driven by uremic pruritus, changes in the renin-angiotensin-aldosterone system, a predisposing immune dysregulation with increased interleukin-31 expression, and opioid system imbalances. A variety of pharmacologic therapies may be efficacious. The use of the new targeted biologics for prurigo nodularis and whether they are also helpful for CKD and acquired perforating dermatitis are welcome.
痒性慢性肾脏疾病(CKD)患者,特别是终末期肾功能衰竭患者中有结节性痒疹(PN)的报道。与CKD和糖尿病相关的获得性穿孔性皮炎(APD)是一组皮肤物质通过表皮消除的疾病,其特征是发痒的丘疹和结节。我们关注CKD中PN和APD之间的关系,并提供数据来支持这两种实体具有许多相同的临床和组织学特征。这些皮肤疾病在这一患者群体中往往报告不足,导致治疗不足和患者预后不佳。我们对文献的回顾表明PN/APD和CKD之间的关系,可能是由尿毒症瘙痒、肾素-血管紧张素-醛固酮系统的变化、IL-31表达增加的易感免疫失调和阿片系统失衡驱动的。多种药物治疗可能有效。新的靶向生物制剂在PN中的应用,以及它们是否对CKD和APD也有帮助,都是值得欢迎的。
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引用次数: 0
Prurigo nodularis imitators unmasked
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 Epub Date: 2025-03-15 DOI: 10.1016/j.clindermatol.2025.03.003
Elisabeth V. Goessinger MD , Tobias Kliesener MD , Beda Muehleisen MD, Oliver Brandt MD, Simon Mueller MD
Prurigo nodularis (PN) is characterized by chronic, nodular lesions on the extensor surfaces of the extremities and back. For experienced clinicians, the recognition of this diagnosis is usually not difficult; however, it is essential to consider differential diagnoses and to identify PN imitators. We report five patients with severe chronic pruritus who presented with skin lesions resembling PN. They were treated accordingly but were subsequently diagnosed with a different underlying disease, including nodular marginal zone lymphoma (1 case), delusional parasitosis (1 case), well-differentiated squamous cell carcinomas arising among PN lesions (2 cases), and PN-like pemphigus foliaceus (1 case). Critical reassessment of the diagnosis of PN is important to avoid cognitive biases such as the availability bias, anchoring bias, or attribution bias, which could lead to delayed diagnosis of the actual disease, inappropriate treatment, and poorer outcome.
结节性痒疹(PN)的特征是四肢和背部伸肌表面的典型慢性结节性病变。对于经验丰富的临床医生来说,识别这种诊断通常并不困难;然而,必须考虑鉴别诊断和识别PN模仿者。我们报告了5例严重慢性瘙痒患者,他们的皮肤病变类似PN。他们接受了相应的治疗,但随后被诊断为不同的基础疾病,包括结节性边缘区淋巴瘤(1例),妄想寄生虫病(1例),PN病变中出现的高分化鳞状细胞癌(2例)和PN样天疱疮(1例)。对PN诊断进行批判性重新评估对于避免认知偏差(如可得性偏差、锚定偏差或归因偏差)非常重要,这些偏差可能导致实际疾病的诊断延迟、治疗不当和预后较差。
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引用次数: 0
The state of artificial intelligence-enabled skin cancer diagnostics: Why are there two spectroscopy devices available yet no imaging devices? 人工智能皮肤癌诊断的现状:为什么有两种光谱设备可用,而没有成像设备?
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 Epub Date: 2025-05-07 DOI: 10.1016/j.clindermatol.2025.05.001
Jay Gopal BS , Albert E. Zhou MD, PhD , Ashfaq A. Marghoob MD , Christian Gronbeck MD , Jane M. Grant-Kels MD
Artificial intelligence (AI) is already impacting the way we diagnose skin diseases. Although there are many new AI tools promoted to be helpful to dermatologists and primary care physicians, especially in the recognition of melanoma and nonmelanoma skin cancers, there is a major obstacle that the sponsoring companies must overcome before it is possible to integrate any of these innovative AI-enabled technologies into clinical practice. The regulatory process of the Food and Drug Administration (FDA) is demanding and requires proof of safety and effectiveness for each of these devices before the FDA gives their approval. Herein we discuss the reasons why there are hundreds of papers applying AI to imaging in dermatology, but the only available FDA-approved AI dermatology tools use spectroscopy.
人工智能(AI)已经在影响我们诊断皮肤病的方式。尽管有许多新的人工智能工具被吹捧为对皮肤科医生和初级保健医生有帮助,特别是在识别黑色素瘤和非黑色素瘤皮肤癌方面,但在将这些创新的人工智能(AI)支持技术整合到临床实践之前,赞助公司必须克服一个主要障碍。美国食品和药物管理局(FDA)的监管程序要求严格,在批准之前需要证明每种设备的安全性和有效性。在这里,我们讨论了为什么有数百篇论文将人工智能应用于皮肤科成像,但唯一可用的fda批准的人工智能皮肤科工具使用光谱学的原因。
{"title":"The state of artificial intelligence-enabled skin cancer diagnostics: Why are there two spectroscopy devices available yet no imaging devices?","authors":"Jay Gopal BS ,&nbsp;Albert E. Zhou MD, PhD ,&nbsp;Ashfaq A. Marghoob MD ,&nbsp;Christian Gronbeck MD ,&nbsp;Jane M. Grant-Kels MD","doi":"10.1016/j.clindermatol.2025.05.001","DOIUrl":"10.1016/j.clindermatol.2025.05.001","url":null,"abstract":"<div><div><span>Artificial intelligence (AI) is already impacting the way we diagnose skin diseases. Although there are many new AI tools promoted to be helpful to dermatologists and </span>primary care<span><span> physicians, especially in the recognition of melanoma and </span>nonmelanoma skin cancers<span>, there is a major obstacle that the sponsoring companies must overcome before it is possible to integrate any of these innovative AI-enabled technologies into clinical practice. The regulatory process of the Food and Drug Administration (FDA) is demanding and requires proof of safety and effectiveness for each of these devices before the FDA gives their approval. Herein we discuss the reasons why there are hundreds of papers applying AI to imaging in dermatology, but the only available FDA-approved AI dermatology tools use spectroscopy.</span></span></div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"43 5","pages":"Pages 687-689"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prurigo nodularis phenotype in the bullous dermatoses spectrum 大疱性皮肤病谱中的结节性痒疹表型。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 Epub Date: 2025-03-19 DOI: 10.1016/j.clindermatol.2025.03.012
Valeria Mateeva MD, PhD, Aylin Kafelova MD, Kossara Drenovska MD, PhD, Snejina Vassileva MD, PhD
Prurigo nodularis (PN) of Hyde is a highly pruritic condition that results from the vicious cycle of itching and scratching. An increasing number of case studies report PN-mimicking lesions in patients with confirmed autoimmune bullous dermatoses (AIBDs). The PN lesions usually precede the blister formation and thus raise the question about the pathogenic relation between the two conditions and the possible role of PN as a trigger of AIBDs. We shed light on PN in the context of AIBDs, especially regarding the clinical characteristics and pathogenesis of the PN-like phenotype of bullous pemphigoid, linear IgA bullous dermatosis, and dermatitis herpetiformis, as well as in the hereditary bullous dermatoses setting, namely, epidermolysis bullosa pruriginosa.
海德结节性痒疹(PN)是一种由瘙痒和抓挠的恶性循环引起的高度瘙痒性疾病。越来越多的病例研究报告,在确诊自身免疫性大疱性皮肤病(aibd)的患者中出现了模仿pn的病变。PN病变通常先于水疱形成,因此提出了这两种情况之间的致病关系以及PN作为aibd的可能触发因素的问题。我们在aibd的背景下阐明PN,特别是大疱性类天疱疮、线状IgA大疱性皮肤病和疱疹样皮炎的PN样表型的临床特征和发病机制,以及遗传性大疱性皮肤病,即大疱性纯性表皮松解症。
{"title":"Prurigo nodularis phenotype in the bullous dermatoses spectrum","authors":"Valeria Mateeva MD, PhD,&nbsp;Aylin Kafelova MD,&nbsp;Kossara Drenovska MD, PhD,&nbsp;Snejina Vassileva MD, PhD","doi":"10.1016/j.clindermatol.2025.03.012","DOIUrl":"10.1016/j.clindermatol.2025.03.012","url":null,"abstract":"<div><div><span>Prurigo nodularis (PN) of Hyde is a highly pruritic condition that results from the vicious cycle of itching and scratching. An increasing number of case studies report PN-mimicking lesions in patients with confirmed autoimmune </span>bullous dermatoses<span><span> (AIBDs). The PN lesions usually precede the blister formation and thus raise the question about the pathogenic relation between the two conditions and the possible role of PN as a trigger of AIBDs. We shed light on PN in the context of AIBDs, especially regarding the clinical characteristics and pathogenesis of the PN-like phenotype of bullous pemphigoid<span>, linear IgA bullous dermatosis, and dermatitis herpetiformis, as well as in the hereditary bullous dermatoses setting, namely, </span></span>epidermolysis bullosa pruriginosa.</span></div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"43 5","pages":"Pages 656-660"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Clinics in dermatology
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