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Prurigo nodularis phenotype in the bullous dermatoses spectrum 大疱性皮肤病谱中的结节性痒疹表型。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 DOI: 10.1016/j.clindermatol.2025.03.012
Valeria Mateeva MD, PhD, Aylin Kafelova MD, Kossara Drenovska MD, PhD, Snejina Vassileva MD, PhD
Prurigo nodularis (PN) of Hyde is a highly pruritic condition that results from the vicious cycle of itching and scratching. An increasing number of case studies report PN-mimicking lesions in patients with confirmed autoimmune bullous dermatoses (AIBDs). The PN lesions usually precede the blister formation and thus raise the question about the pathogenic relation between the two conditions and the possible role of PN as a trigger of AIBDs. We shed light on PN in the context of AIBDs, especially regarding the clinical characteristics and pathogenesis of the PN-like phenotype of bullous pemphigoid, linear IgA bullous dermatosis, and dermatitis herpetiformis, as well as in the hereditary bullous dermatoses setting, namely, epidermolysis bullosa pruriginosa.
海德结节性痒疹(PN)是一种由瘙痒和抓挠的恶性循环引起的高度瘙痒性疾病。越来越多的病例研究报告,在确诊自身免疫性大疱性皮肤病(aibd)的患者中出现了模仿pn的病变。PN病变通常先于水疱形成,因此提出了这两种情况之间的致病关系以及PN作为aibd的可能触发因素的问题。我们在aibd的背景下阐明PN,特别是大疱性类天疱疮、线状IgA大疱性皮肤病和疱疹样皮炎的PN样表型的临床特征和发病机制,以及遗传性大疱性皮肤病,即大疱性纯性表皮松解症。
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引用次数: 0
Xerosis cutis and wounded skin in modern art: Two works by Alberto Burri 现代艺术中的皮肤干燥症和受伤的皮肤:阿尔贝托-布里的两幅作品
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 DOI: 10.1016/j.clindermatol.2025.03.001
Uwe Wollina MD , Leonhard J. Hoenig MD , Lawrence Charles Parish MD, MD (Hon), FRCP (Edin)
 The human skin has been a subject of medicine and art. The interest in the interaction of skin and the inner body had increased after the establishment of anatomy as a science long before dermatology was acknowledged as a medical discipline. In painting the body surface, the Inkarnat (flesh tone) represents a mixture of the superficial epidermis and dermis, plus the deeper musculature and vasculature, each contributing to the skin color. In the fine arts of the Renaissance, skin is understood as primarily a layer of material. The human skin can express feelings, emotions, and various states of mind. We analyze two works of the Italian artist Alberto Burri (1915-1995), who painted in the postwar period. He opens a window into human existence with his materials while showing tragedies and wounds.
人体皮肤一直是医学和艺术的主题。早在皮肤病学被公认为一门医学学科之前,解剖学作为一门科学建立之后,人们对皮肤和身体内部相互作用的兴趣就增加了。在绘制身体表面时,Inkarnat(肤色)代表了表皮和真皮的混合物,加上深层的肌肉组织和脉管系统,每一个都有助于肤色。在文艺复兴时期的美术中,皮肤主要被理解为一层材料。人类的皮肤可以表达感情、情绪和各种精神状态。我们分析意大利艺术家阿尔贝托·布里(1915-1995)的两幅作品,他在战后时期作画。他在展示悲剧和创伤的同时,用素材打开了一扇通向人类存在的窗户。
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引用次数: 0
Evolving evidence in the neural sensitization of prurigo nodularis 结节性痒疹神经致敏的新证据。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 DOI: 10.1016/j.clindermatol.2025.03.008
Sarah G. Brooks BA, Gil Yosipovitch MD
Prurigo nodularis is a chronic inflammatory skin disorder characterized by relentlessly pruritic, hyperkeratotic nodules. Recent studies have provided compelling evidence for the pivotal role of dysregulated interactions between the nervous and immune systems in its pathogenesis. This article reviews the latest findings on the neurogenic mechanisms contributing to prurigo nodularis, particularly how these processes lead to the sensation of increased itch intensity. Peripheral sensitization is primarily driven by abnormal innervation of histamine-independent, small unmyelinated C fibers, epidermal hypoplasia, and dermal hyperinnervation. This sensitization is further amplified by the cyclic release of neuropeptides such as Substance P, calcitonin gene-related peptide, and nerve growth factor. Although the mechanisms underlying central sensitization in prurigo nodularis remain less understood, it likely involves enhanced itch signaling in the dorsal spinal cord or a lowered threshold for itch perception. Additionally, parallels between pruritus and pain–such as allodynia and alloknesis, as well as hyperalgesia and hyperknesis-along with the association of prurigo nodularis with various comorbid systemic conditions, offer valuable insights into the disorder's pathology. A deeper understanding of the complex neural sensitization mechanisms in prurigo nodularis may lead to the identification of novel therapeutic targets, ultimately alleviating the burden of this debilitating condition.
结节性痒疹是一种慢性炎症性皮肤病,其特征是持续瘙痒,角化结节过度。最近的研究提供了令人信服的证据,证明神经和免疫系统之间的相互作用失调在其发病机制中起着关键作用。本文综述了有关结节性痒疹的神经源性机制的最新发现,特别是这些过程如何导致瘙痒强度增加的感觉。外周致敏主要由不依赖组胺的小无髓C纤维的异常神经支配、表皮发育不全和真皮神经支配过度驱动。这种致敏作用被神经肽的循环释放进一步放大,如P物质、降钙素基因相关肽和神经生长因子。尽管结节性痒疹中枢致敏的机制尚不清楚,但它可能与脊髓背侧瘙痒信号增强或瘙痒感知阈值降低有关。此外,瘙痒和疼痛之间的相似之处,如异位性痛觉和异位性疼痛,以及痛觉过敏和痛觉亢进,以及结节性痒疹与各种共病系统疾病的关联,为该疾病的病理提供了有价值的见解。对结节性痒疹复杂的神经致敏机制的深入了解可能会导致新的治疗靶点的确定,最终减轻这种使人衰弱的疾病的负担。
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引用次数: 0
Microneedling radiofrequency followed by topical exosome application therapy for pattern hair loss: A scoping review and prospective study 微针射频后外用外显体应用治疗模式脱发:一项范围回顾和前瞻性研究。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 DOI: 10.1016/j.clindermatol.2025.07.006
Ioannis-Alexios Koumprentziotis MD , Eleni Kroumpouzos BA , Shohreh Delavar MD , George Kroumpouzos MD, PhD
Microneedling radiofrequency (MNRF) and exosome therapies have recently garnered attention as potential treatments for pattern hair loss (PHL). This study aimed to conduct a scoping review of these treatments and present a series of patients with PHL treated with MNRF followed by topical exosome application therapy. We searched the PubMed, Google Scholar, and Cochrane databases for relevant articles regarding MNRF and exosome treatments for PHL. Our search yielded two studies on MNRF and nine studies on exosome therapy, all of which demonstrated positive effects on hair regrowth. One of these studies specifically focused on MN combined with exosome therapy. In our current study, we prospectively evaluated the efficacy and safety of MNRF followed by topical exosome application in 20 patients (median age, 46 years), comprising 16 men and four women, with PHL. Clinical evaluations were conducted using macroscopic photographs and digital image analysis with a trichoscopy device at baseline and then again at three, six, and nine months after treatment. The median followup duration was 10 months. Our results revealed significant increases in mean hair density and diameter, along with high patient satisfaction. No adverse events were reported. The treatment response was found to be independent of sex and the severity of PHL. Overall, this study underscores the potential therapeutic benefits of the MNRF followed by topical exosome application therapy. Randomized controlled trials, however, are needed to confirm the efficacy of this therapy and to determine the optimal treatment parameters.
微针射频(MNRF)和外泌体治疗最近引起了人们的关注,因为它们是治疗型脱发(PHL)的潜在方法。本研究旨在对这些治疗方法进行范围审查,并介绍了一系列接受MNRF治疗的PHL患者,然后进行局部外泌体应用(MNRF- exo)治疗。我们检索了PubMed、谷歌Scholar和Cochrane数据库中有关MNRF和外泌体治疗PHL的相关文章。我们的研究获得了两项关于MNRF的研究和九项关于外泌体治疗的研究,这些研究都证明了对头发再生的积极作用。其中一项研究特别关注微针与外泌体治疗的结合。在我们目前的研究中,我们前瞻性地评估了20例PHL患者(中位年龄46岁)MNRF-Exo的疗效和安全性,其中包括16名男性和4名女性。临床评估采用宏观照片和数字图像分析,在基线时,然后在治疗后3、6和9个月再次进行。中位随访时间为10个月。我们的结果显示,平均头发密度和直径显著增加,患者满意度也很高。无不良事件报告。治疗反应与性别和PHL的严重程度无关。总的来说,这项研究强调了MNRF-Exo疗法的潜在治疗益处。然而,需要随机对照试验来证实该疗法的疗效并确定最佳治疗参数。
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引用次数: 0
Neurocosmetics are cosmetics, which mean that they could have effects only on skin 神经化妆品是化妆品,这意味着它们只能对皮肤起作用。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 DOI: 10.1016/j.clindermatol.2025.07.002
Laurent Misery MD, PhD , Howard I. Maibach MD , John Koo MD , Mohammad Jafferany MD
Neurocosmetics have been used since the 1990s and are defined as products that are supposed to modulate the neuro-immuno-cutaneous system functioning at the epidermal level. They have many potential applications, such as sensitive skin, skin stress, skin aging, pigmentation disorders, redness, skin regeneration, and skin inflammation. Cosmetics with pleasant properties are not neurocosmetics, and nothing new is being offered. Of more concern, some pseudo-neurocosmetics contain agonists and antagonists of neurotransmitters and, subsequently, potential effects on the central nervous system. These products are not cosmetics. There is an urgent need to inform patients, especially those with psychologic fragility.
神经化妆品自20世纪90年代开始使用,被定义为“在表皮水平上调节神经-免疫皮肤系统功能的产品”。它们有许多潜在的应用,如敏感皮肤、皮肤压力、皮肤老化、色素沉着障碍、红肿、皮肤再生和皮肤炎症。具有令人愉悦的特性的化妆品不是神经化妆品,也没有什么新的东西可以提供。更令人担忧的是,一些伪神经化妆品含有神经递质的激动剂和拮抗剂,随后对中枢神经系统产生潜在影响。这些产品不是化妆品。迫切需要告知患者,特别是那些心理脆弱的患者。
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引用次数: 0
Comorbidities in prurigo nodularis
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 DOI: 10.1016/j.clindermatol.2025.09.001
Jaya Manjunath BS , Brenda Umenita Akinniyi MS , Alexander L. Kollhoff MD , Shawn G. Kwatra MD
Prurigo nodularis (PN) is a chronic inflammatory skin condition characterized by intense pruritus and hyperkeratotic nodules commonly found on the trunk and extremities. The pathogenesis of PN involves neuroimmune dysregulation, mediated by various inflammatory cytokines and neuropeptides. PN significantly impacts patients' quality of life. There is greater disease severity, increased itch intensity, and a more pronounced reduction in quality of life in PN compared with other individuals with chronic pruritus. PN is associated with a range of systemic comorbidities, including chronic kidney disease, cardiovascular disease, metabolic disorders, HIV and tuberculosis infection, hepatic disorders, and autoimmune diseases. Additionally, PN is frequently accompanied by psychiatric comorbidities such as depression, anxiety, and obsessive-compulsive disorder, further complicating management. Sleep disturbances and neurologic comorbidities, including neuropathic pain and central sensitization, are also common in PN patients. Diagnosis should include a comprehensive review of systems to assess for comorbidities and evaluate disease severity, guiding personalized treatment approaches. Management strategies aim to reduce itch severity and improve quality of life, often involving immunosuppressants, neuromodulators, or emerging biologics such as dupilumab.
结节性痒疹(Prurigo结节,PN)是一种慢性炎症性皮肤病,以强烈瘙痒和角化结节为特征,常见于躯干和四肢。PN的发病机制涉及多种炎症细胞因子和神经肽介导的神经免疫失调。PN显著影响患者生活质量(QOL)。与其他慢性瘙痒患者相比,PN患者的疾病严重程度更高,瘙痒强度增加,生活质量下降更明显。PN与一系列全身性合并症有关,包括慢性肾病、心血管疾病、代谢紊乱、HIV和结核感染、肝脏疾病和自身免疫性疾病。此外,PN经常伴有精神合并症,如抑郁、焦虑和强迫症,进一步使治疗复杂化。睡眠障碍和神经系统合并症,包括神经性疼痛和中枢致敏,在PN患者中也很常见。诊断应包括对系统的全面审查,以评估合并症和评估疾病严重程度,指导个性化治疗方法。治疗策略旨在减轻瘙痒严重程度和改善生活质量,通常涉及免疫抑制剂、神经调节剂或新兴生物制剂,如杜匹单抗。
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引用次数: 0
Diagnosis and management of prurigo nodularis in skin of color patients 有色皮肤结节性痒疹的诊断与治疗。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 DOI: 10.1016/j.clindermatol.2025.03.004
Akash Rau BS , Danyelle Dawes MD
Prurigo nodularis is a chronic, intensely pruritic eruption that results in excoriated papules, mostly on the extensor surfaces of the arms and legs. Previous studies have indicated that the condition disproportionally affects those of African descent. Although the etiology has not been fully elucidated, patients with prurigo nodularis have been found to have associated comorbidities such as hypertension, renal disease, and HIV infection. This review covers the principles of work-up and diagnosis of prurigo nodularis in skin of color patients as well as management considerations in this population.
结节性痒疹是一种慢性的、强烈的瘙痒性皮疹,主要在手臂和腿部的伸肌表面产生瘙痒性丘疹。先前的研究表明,这种情况对非洲裔的影响尤为严重。虽然病因尚未完全阐明,但结节性痒疹患者已发现有相关的合并症,如高血压、肾脏疾病和HIV感染。本文综述了有色皮肤患者结节性痒疹的检查和诊断原则以及该人群的管理注意事项。
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引用次数: 0
Dermatologists Who Have Been Knighted by the Kings and Queens of England 被英国国王和女王封为骑士的皮肤科医生。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 DOI: 10.1016/j.clindermatol.2025.06.001
Leonard J. Hoenig MD , Uwe Wollina MD , Nick J. Levell MD, FRCP, MBA , Lawrence Charles Parish MD, MD (Hon), FRCP (Edin)
This contribution highlights the biographies of 12 physicians, 11 of whom were dermatologists, knighted by British monarchs over the past 150 years. They are: William JamesErasmus Wilson (1809-1884), Dyce Duckworth (1840-1928), Thomas McCall Anderson (1836-1908), Jonathan Hutchinson (1828-1913), Malcolm Morris (1849-1924), James Galloway (1862-1922), Aldo Castellani (1874-1971), Humphrey Rolleston (1862-1944), Norman Purvis Walker (1862-1942), Robert Bolam (1871-1939), Ernest Graham-Little (1867-1950), and Archibald M. H. Gray (1880-1967).
We also highlight the lives of two physicians honored as members of the Order of the British Empire: Nigel Vincent Delahunty Bunker (1927-1967) and dermatologist Nick J. Levell, as well as Nigel’s son, the noted dermatologist Christopher B. Bunker, who was awarded the 2019 Sir Archibald Gray Prize and Medal for outstanding work in dermatology.
这一贡献突出了12位医生的传记,其中11位是皮肤科医生,在过去的150年里被英国君主封为爵士。他们包括:伊拉斯谟·威尔逊(1809-1884)、戴斯·达克沃斯(1840-1928)、托马斯·麦考尔·安德森(1836-1908)、乔纳森·哈钦森(1828-1913)、马尔科姆·莫里斯(1847-1924)、詹姆斯·加洛韦(1862-1922)、阿尔多·卡斯特拉尼(1874-1971)、汉弗莱·罗莱斯顿(1862-1944)、诺曼·珀维斯·沃克(1862-1942)、罗伯特·波拉姆(1871-1939)、欧内斯特·格雷厄姆·利特尔(1867-1950)和阿奇博尔德·格雷(1880-1967)。我们还重点介绍了两位被授予大英帝国勋章的医生的生活:奈杰尔·文森特·德拉汉蒂·邦克(1927-1967)和皮肤科医生尼克·j·利维尔,以及奈杰尔的儿子,著名皮肤科医生克里斯托弗·b·邦克,他因在皮肤科的杰出工作而被授予2019年阿奇博尔德·格雷爵士奖和奖章。
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引用次数: 0
From patients to partners: Ethical complexities of maintaining professional boundaries in a digital age 从患者到合作伙伴:数字时代保持专业界限的伦理复杂性。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 DOI: 10.1016/j.clindermatol.2025.02.006
Shannon Hanggodo BS , Timothy Klufas BA , Simran Saini BS , Albert E. Zhou MDPhD , Gillian Weston MD , Jane M. Grant-Kels MD
Professional ethics prohibit physicians from dating current patients due to risks of exploitation, compromised objectivity, and power imbalances, conflicting with obligations of beneficence and nonmaleficence. Online dating applications or appls" complicate these boundaries, as a physician's online presence may inadvertently enable patient encounters outside professional contexts. To maintain ethical standards, physicians should avoid sharing identifiable information on dating platforms, ensure patient care is transferred before pursuing romantic relationships, and adhere to institutional policies that mitigate risks and uphold transparency.
职业道德禁止医生与现有病人约会,因为存在剥削、客观性受损和权力失衡的风险,这与慈善和非恶意的义务相冲突。在线约会应用程序或应用程序使这些界限复杂化,因为医生的在线存在可能会无意中使患者接触到专业环境之外的情况。为了保持道德标准,医生应避免在约会平台上分享可识别的信息,确保在追求恋爱关系之前转移患者护理,并坚持降低风险和保持透明度的制度政策。
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引用次数: 0
Prurigo Nodularis 结节性瘙痒 - 皮肤科临床。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-09-01 DOI: 10.1016/j.clindermatol.2025.03.002
Gil Yosipovitch MD , Sarah G. Brooks BA
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引用次数: 0
期刊
Clinics in dermatology
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