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Are systemic sclerosis and localized scleroderma (morphea) part of a common disease spectrum? A systematic review on their coexistence 系统性硬化症和硬皮病/局部硬皮病是常见疾病谱系的一部分吗?对两者共存的系统回顾。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.09.032
Carolina De Rosa MD , Giorgia Di Marco MD , Vanessa Bottino MD , Nazario Pesce MD , Antonio Podo Brunetti MD , Giorgio Stabile MD , Stefania Guida MD , Franco Rongioletti MD
Scleroderma encompasses systemic sclerosis (SSc), which may be divided into limited cutaneous and diffuse cutaneous forms, as well as localized scleroderma (LoS), also known as morphea, each with distinct yet overlapping features. Although SSc affects internal organs, LoS (morphea) is typically confined to skin and the underlying tissues. We reviewed the records from 23 studies of 57 patients for coexistence of SSc and LoS (morphea). The majority of patients were women (84%) with a mean disease onset age of 44 years. Limited cutaneous SSc (46%) and nodular morphea (25%) were the most frequent subtypes. Raynaud phenomenon (63%) and sclerodactyly (53%) were common systemic manifestations, with severe complications, such as interstitial lung disease (25%) and esophageal dysmotility (18%), observed in 35% of the patients. Autoantibodies were detected in 67% of the patients, with anti-centromere (28%) and anti-nuclear (23%) antibodies as the most frequent markers. Disease sequencing showed SSc preceding LoS (morphea) in 47% of cases (mean latency: five years), LoS (morphea) preceding SSc in 26% (latency: seven years), and concurrent onset in 26%, often with generalized morphea. The coexistence suggests shared pathogenic mechanisms involving autoimmunity and TGF-β-mediated fibrosis. Treatment data were limited but indicated partial to complete improvement with systemic steroids, immunosuppressants, and other modalities. These findings highlight the importance of monitoring LoS (morphea) patients, particularly those with Raynaud phenomenon or autoantibody positivity, for potential progression to SSc. The overlap supports considering SSc and LoS (morphea) as a continuum rather than distinct entities.
硬皮病包括系统性硬皮病(SSc),可分为局限性皮肤硬皮病(lcSSc)和弥漫性皮肤硬皮病(dcSSc),以及局限性硬皮病(LoS),也称为morphea,每一种硬皮病都具有不同但重叠的特征。当SSc影响内部器官时,morphea/LoS通常局限于皮肤和底层组织。我们回顾了57例SSc和LoS共存患者的23项研究记录。大多数患者为女性(84%),平均发病年龄为44岁。局限性皮肤性SSc(46%)和结节性morphea(25%)是最常见的亚型。雷诺现象(63%)和指硬症(53%)是常见的全身性表现,35%的患者伴有间质性肺疾病(25%)和食管运动障碍(18%)等严重并发症。67%的患者检测到自身抗体,其中ACA(28%)和ANA(23%)是最常见的标志物。疾病测序显示,47%的病例(平均潜伏期:5年)SSc先于morphea/LoS, 26%的病例(潜伏期:7年)morphea/LoS先于SSc, 26%的病例同时发病,通常伴有全身性morphea。这种共存提示了共同的致病机制,包括自身免疫和tgf - β介导的纤维化。治疗数据有限,但表明全身性类固醇、免疫抑制剂和其他方式部分或完全改善。这些发现强调了监测morphea/LoS患者的重要性,特别是那些有雷诺现象或自身抗体阳性的患者,以防止潜在的SSc进展。这种重叠支持将SSc和morphea/LoS视为连续体,而不是不同的实体。
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引用次数: 0
Ethics of reversible dermatologic care in transgender and gender-diverse adolescents under restrictive and ambiguous laws 在限制和模糊的法律下,变性和性别多样化(TGD)青少年的可逆皮肤护理伦理。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.02.010
Priya Patel Housley MS , Sami K. Saikaly MD , Neelesh Jain MD , Jane M. Grant-Kels MD
Gender dysphoria causes significant distress in transgender and gender-diverse (TGD) adolescents, often impacting their mental health. Evidence-based gender-affirming interventions, such as hormone therapy, have been shown to reduce this distress and lower suicide risk, and dermatological treatments may help alleviate gender dysphoria. However, recent state-specific legal restrictions and ambiguous laws in the United States (US) have created barriers for TGD adolescents from accessing these treatments; some states have passed new laws that restrict TGD youth access to surgical and even medical gender affirming services as hormone treatment. We explore dermatologists’ challenges in providing care to TGD adolescents in legally ambiguous and restrictive states in the context of the core ethical principles of autonomy, beneficence, nonmaleficence, and justice. Using exemplary case studies, we discuss ethical dilemmas involving dermal fillers, laser hair removal, hair growth treatments, and acne management for TGD adolescents living in such states. We find that as such treatments are available in other geographic locations, available for cis-gender individuals and not necessarily permanent, there is a violation of the core principle of justice. Dermatologists should navigate these legal and ethical complexities to provide safe, compassionate care for TGD adolescents. Advocacy for clear state-specific guidelines, equitable access to care, and ongoing research are essential to support this vulnerable population.
性别焦虑症对跨性别和性别多样化青少年造成严重困扰,往往影响他们的心理健康。以证据为基础的性别肯定干预措施,如激素治疗,已被证明可以减少这种痛苦并降低自杀风险,皮肤病治疗可能有助于减轻性别不安;然而,美国最近各州的具体法律限制和模棱两可的法律为TGD青少年获得这些治疗创造了障碍。我们探讨皮肤科医生的挑战,在自主、慈善、无害和正义的核心伦理原则的背景下,在法律上模棱两可和限制性的状态下,为TGD青少年提供护理。通过典型案例研究,我们讨论了涉及真皮填充物、激光脱毛、毛发生长治疗以及生活在这种状态下的TGD青少年的痤疮管理的伦理困境。我们发现,由于这种治疗在其他地理位置也有,对顺性人也有,而且不一定是永久性的,这违反了正义的核心原则。皮肤科医生必须驾驭这些法律和伦理的复杂性,为TGD青少年提供安全、富有同情心的护理。倡导明确的各州具体指导方针、公平获得医疗服务和正在进行的研究对于支持这一弱势群体至关重要。
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引用次数: 0
Identifying predictors of success in dermatology residency: A multicenter retrospective study. 确定皮肤科住院医师成功的预测因素:一项多中心回顾性研究。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-10-31 DOI: 10.1016/j.clindermatol.2025.10.009
Gabriel Rice, Gabriella VanAken, Steven Daveluy, Yolanda Helfrich

Identifying applicants who will be successful dermatology residents requires a tremendous effort every year. The objective of the current study was to determine if application characteristics are predictive of success in dermatology residency. We conducted a retrospective cohort study utilizing applications of dermatology residents from the University of Michigan (2011-2016) and Wayne State University (2009-2019). The residents' clinical abilities and collegiality were retrospectively assessed by faculty based on a scale from 1 (Problematic, I would not recommend this person as a colleague or physician) to 4 (Great, I would love to have this person as a colleague and would recommend this person to family and friends as a physician). The relationship between faculty ratings and application characteristics was evaluated through multivariable regression. Ninety-one total residents were included in the study, with 48 from University of Michigan and 43 from Wayne State University . Nine faculty from University of Michigan and six faculty from Wayne State University evaluated residents. The average faculty rating of residents was 2.5 ± 0.5. Board examination scores were associated with higher faculty ratings (Step 1, β: 0.007; 95% CI: 0.001, 0.013; P = .03; Step 2, β: 0.008; 95% CI: 0.001, 0.014; P = .02). High level of athletic achievement was also associated with higher average faculty ratings (β: 0.310; 95% CI: 0.051, 0.569; P = .02). Our study suggests that board examination scores and athletic achievement are associated with success in dermatology residency. Further research is needed to fully understand the relationship between these factors and their utility in evaluating prospective candidates.

确定申请人谁将是成功的皮肤科住院医师每年需要巨大的努力。当前研究的目的是确定应用特征是否预示着皮肤科住院医师的成功。我们利用密歇根大学(UM)(2011年至2016年)和韦恩州立大学(WSU)(2009年至2019年)皮肤科住院医师的应用程序进行了一项回顾性队列研究。住院医生的临床能力和合作关系是由教师根据从1(有问题,我不会推荐这个人作为同事或医生)到4(很好,我很乐意有这个人作为同事,并将这个人推荐给家人和朋友作为医生)的等级进行回顾性评估的。通过多变量回归评估教师评分与申请特征之间的关系。共有91名居民参与了这项研究,其中48名来自密歇根大学,43名来自华盛顿州立大学。来自UM的9名教员和来自WSU的6名教员对居民进行了评估。住院医师的平均教师评分为2.5±0.5。委员会考试成绩与较高的教师评分相关(步骤1 Beta: 0.007, 95% CI [0.001, 0.013], p值:0.03;步骤2 Beta: 0.008, 95% CI [0.001, 0.014], p值:0.02)。高水平的运动成绩也与较高的教师平均评分相关(Beta值:0.310,95% CI [0.051, 0.569], p值:0.02)。我们的研究表明,委员会考试成绩和运动成绩与皮肤科住院医师的成功有关。需要进一步的研究来充分了解这些因素之间的关系及其在评估潜在候选人时的效用。
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引用次数: 0
Rising retractions in dermatology (2006-2024): Causes, geographic disparities, and post-retraction citation risk. 皮肤科论文撤稿上升(2006-2024):原因、地域差异和撤稿后引用风险
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-10-30 DOI: 10.1016/j.clindermatol.2025.10.008
Lu Yuan, Daohuan Kang, Jia Feng, Jiao Zhan, Kai Jin, Andrzej Grzybowski

We analyzed dermatology retraction trends (2006-2024) by examining causes, geographic distribution, journal metrics, and citation patterns. Our purpose was to identify systemic issues and propose solutions to enhance research integrity and mitigate postretraction citation risks in the field. A bibliometric analysis was conducted on 280 retracted dermatology contributions from the Retraction Database (2006-2024), supplemented by Scopus for publication and citation data. The annual number of retractions showed a highly significant increase over the period, peaking at 74 in 2023. Academic misconduct (data fabrication/tampering and plagiarism) was the leading cause, accounting for 45% of all retractions. United States had the highest absolute count (n = 80), whereas China exhibited the highest normalized retraction rate (357 per 10,000 publications), contrasting sharply with the US rate (19.7 per 10,000). Postretraction citation analysis (n = 80 contributions) revealed a high proportion of inappropriate citations (30%). The sharply increasing retraction trend, driven largely by misconduct and geographic disparities, requires urgent, multilevel interventions, including stricter oversight, ethical training, and improved peer review. Addressing postretraction citations is critical to curbing misinformation.

我们通过检查原因、地理分布、期刊指标和引用模式,分析了皮肤病学撤回趋势(2006-2024)。我们的目的是确定系统性问题,并提出解决方案,以提高研究的完整性,降低该领域的撤稿后被引风险。对撤稿数据库(2006-2024)中的280篇皮肤病学撤稿论文进行文献计量学分析,并辅以Scopus的出版和引文数据。在此期间,年度撤稿数量大幅增加,2023年达到74篇的峰值。学术不端行为(数据伪造/篡改和剽窃)是主要原因,占所有撤稿的45%。虽然美国的绝对撤稿率最高(n=80),但中国的标准化撤稿率最高(每万篇论文357篇),与美国的撤稿率(每万篇19.7篇)形成鲜明对比。撤稿后引文分析(n=80篇文章)显示,不恰当引文的比例很高(30%)。撤稿趋势急剧增加,这主要是由不当行为和地域差异造成的,需要紧急的多层次干预,包括更严格的监督、道德培训和改进的同行评审。解决撤稿后引用问题对于遏制错误信息至关重要。
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引用次数: 0
ASAP revisited: The Brazilian sequential algorithm for treating keloids and hypertrophic scars. ASAP重访:治疗瘢痕疙瘩和增生性疤痕的巴西顺序算法。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-10-29 DOI: 10.1016/j.clindermatol.2025.10.011
Gisele Viana de Oliveira, Leandra D'Orsi Metsavaht, George Kroumpouzos

Treatment of keloids and hypertrophic scars poses a significant challenge. Several treatments are beneficial, including surgery, technologies such as lasers, medication injections (eg, triamcinolone and antineoplastic drugs), cryotherapy, and radiation, but recurrence rates are high after all of these procedures. The ASAP algorithm is a rational, sequential, nonsurgical approach to treating keloids and hypertrophic scars, described by the authors several years ago; after applying it, recurrence rates are very low. ASAP stands for the following steps: A, assessment of the keloid or hypertrophic scar; S, soften the lesion using occlusive dressings; A, approach the scar or keloid utilizing a combination of technologies and injectable antifibrosant drugs; and finally, P, pigmentary alteration treatment. This algorithm was initially popularized in Brazil and has been adopted at several centers; however, with the advent of new technologies and drugs to treat keloids and hypertrophic scars, it has undergone significant improvement. This overview offers an updated perspective on the ASAP sequential algorithm. New research data, including the benefits of microneedling and medications such as verapamil and botulinum toxin, as well as the improvement of hyperpigmentation with picosecond laser, have been incorporated into the ASAP protocol. The importance of integrating diverse therapeutic modalities is highlighted. This sequential stepwise approach promotes gradual clinical improvement while minimizing the likelihood of recurrence.

瘢痕疙瘩和增生性疤痕(HS)的治疗提出了重大挑战。一些治疗方法是有益的,包括手术、激光等技术、药物注射(如曲安奈德、抗肿瘤药物)、冷冻疗法和放疗,所有这些都有很高的复发率。ASAP算法是一种合理的,顺序的,非手术的方法来治疗瘢痕疙瘩和HS,由这些作者几年前描述,其复发率非常低。ASAP代表以下步骤:A,评估瘢痕疙瘩或HS;S,使用闭塞敷料软化病变;A,结合使用技术和注射抗纤维化药物治疗疤痕或瘢痕疙瘩;最后,P,色素改变处理。该算法最初在巴西推广,并已在多个中心采用;然而,随着治疗瘢痕疙瘩和HS的新技术和药物的出现,它已经有了显着的改善。这个概述提供了ASAP顺序算法的最新视角。新的研究数据,包括微针和维拉帕米、肉毒杆菌毒素等药物的益处,以及皮秒激光对色素沉着的改善,已被纳入ASAP协议。强调了综合多种治疗方式的重要性。这种循序渐进的方法促进临床逐渐改善,同时尽量减少复发的可能性。
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引用次数: 0
Dermatologic conditions and stigma: The depiction of acne in cartoons. 皮肤病和病耻感:漫画中痤疮的描述。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-10-29 DOI: 10.1016/j.clindermatol.2025.10.012
Sophie Walter

Acne affects almost 10% of the world's population, and sufferers are often stigmatized; yet, media portrayals of the condition have received little academic attention. Media depictions can shape public views about medical disorders. This study examined the portrayal of acne in readily accessible cartoons to creatively inform education campaigns about the condition. The image sections of various internet search engines and the online cartoon library CartoonStock were inspected for single-panel cartoons that made specific reference to acne. Each cartoon was then examined according to an instrument with categories for describing the themes about acne, the suggested etiology, treatment methods, and outcome. Ninety-three cartoons were identified. Common themes included acne causing despair for sufferers, being fervently hidden from others, and impairing the formation of intimate relationships. No cartoon made reference to retinoids or other newer acne treatments, and positive outcomes were rarely depicted. It is hoped that future cartoon portrayals of acne may be able to offer more optimistic messages about the condition.

痤疮影响着世界上近10%的人口,患者经常被污名化;然而,媒体对这种情况的描述几乎没有得到学术界的关注。媒体的描述可以塑造公众对医学疾病的看法。这项研究检查了容易接近的漫画中痤疮的写照,以便告知创造性的教育活动关于这种情况。图像部分的各种互联网搜索引擎和在线卡通图书馆卡通股票®检查了单面板漫画,具体涉及痤疮。然后根据描述痤疮主题、建议的病因、治疗方法和结果的工具分类检查每个漫画。确定了94幅漫画。常见的主题包括痤疮,它会让患者感到绝望,但却极力隐藏起来,损害亲密关系的形成。没有漫画提到类维生素a或其他较新的痤疮治疗方法,而且很少描绘积极的结果。人们希望未来关于痤疮的卡通形象能够提供更多乐观的信息。
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引用次数: 0
Red marble and the art for peace: An example from the Great Northern Wars (1700-1772). 红色大理石与和平艺术。以北方大战争(1700-1772)为例。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-10-28 DOI: 10.1016/j.clindermatol.2025.10.007
Uwe Wollina, Andreas Nowak, Leonard J Hoenig, Lawrence Charles Parish

Red marble is a rare limestone found in the Ore Mountains of Saxony, Germany. It was used by a court goldsmith, Johann Heinrich Köhler (1669-1736), to create a sculpture for King Augustus the Strong (1670-1733) and for his widely known Green Vault in the Royal Palace of Dresden. This treasured small figure of a disabled Swedish Grenadier depicts the bloody experience of the battlefield during the Great Northern War (1700-1721) in the German States. The grenadier sculpture also conveys a positive message to the viewer, intended to guide the prevention of death and suffering-an art object for peace.

红色大理石是一种罕见的石灰石,发现于德国萨克森州的矿石山脉。它曾被宫廷金匠约翰·海因里希Köhler(1669-1736)用来为国王奥古斯都(1670-1733)和他在德累斯顿皇宫中著名的绿色穹顶制作雕塑。这个珍贵的残疾瑞典掷弹兵的小雕像描绘了大北方战争(1700-1721)期间德国战场上的血腥经历。掷弹兵雕塑也向观众传达了积极的信息,旨在指导防止死亡和痛苦-和平的艺术对象。
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引用次数: 0
Dermatology-related disorders named after patients. 以患者命名的皮肤病相关疾病。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-10-24 DOI: 10.1016/j.clindermatol.2025.10.003
Leonard J Hoenig, Uwe Wollina, Lawrence Charles Parish

This contribution presents 14 dermatology-related eponyms that honor the patients who helped define the clinical entities and disorders that bear their names or initials. These clinical entities and disorders include: (1) anti-La antibodies, (2) anti-Ro antibodies, (3) anti-Sm antibodies, (4) B-K mole syndrome, (5) Hela cells, (6) Carrion disease, (7) Christmas disease, (8) Cowden syndrome, (9) Hageman disease, (10) Hartnup disease, (11) Mortimer malady, (12) rickettsiosis, (13) Schamroth sign, and (14) Trousseau syndrome.

这一贡献提出了14个皮肤病学相关的名字,以纪念那些帮助定义临床实体和疾病的患者,他们的名字或首字母缩写。这些临床实体和疾病包括:1)抗la抗体,2)抗ro抗体,3)抗sm抗体,4)B-K痣综合征,5)海拉细胞,6)腐肉病,7)圣诞病,8)考登综合征,9)哈格曼病,10)哈特纳普病,11)莫蒂默病,12)立克次体病,13)沙姆罗斯氏征,14)特鲁索综合征。
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引用次数: 0
Clinical and ethical considerations in nanotechnology-based dermatologic care. 基于纳米技术的皮肤护理的临床和伦理考虑。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-10-16 DOI: 10.1016/j.clindermatol.2025.10.004
Isabella J Tan, Tarek Zieneldien, Sophia Ma, Jane M Grant-Kels

Nanodermatology is the application of nanotechnology specifically to dermatology. We discuss the pros and cons of translating these innovations into routine dermatology practice, as well as the unique safety challenges, regulatory issues, and ethical and equity concerns surrounding nanodermatology. Unlike other emerging technologies, nanodermatology involves transcutaneous exposure to engineered nanoparticles that may penetrate beyond the epidermis, persist in tissues, and accumulate systemically. These characteristics create distinct safety and ethical challenges, including invisible patient exposure, uncertain long-term toxicologic effects, and unequal regulatory oversight across countries. The specific ethical issues involve nonmaleficence, informed consent, privacy, autonomy, and justice.

纳米皮肤病学是纳米技术专门应用于皮肤病学。我们讨论了将这些创新转化为常规皮肤医学实践的利弊,以及围绕纳米皮肤医学的独特安全挑战、监管问题以及伦理和公平问题。与其他新兴技术不同,纳米皮肤病学涉及经皮暴露于工程纳米颗粒,这些纳米颗粒可能穿透表皮,持续存在于组织中,并在全身积累。这些特点带来了明显的安全和伦理挑战,包括看不见的患者暴露、不确定的长期毒理学效应以及各国监管监督的不平等。具体的伦理问题包括非恶意、知情同意、隐私、自主和正义。纳米技术正在成为皮肤病学的关键前沿,其应用范围从靶向药物递送到纳米级诊断传感器和先进的化妆品配方例如,基于纳米颗粒的外用制剂可增加免疫调节剂进入银屑病斑块的递送,用于增强他克莫司角质层渗透的胶束载体,以及能够实时检测炎症生物标志物的纳米传感器最近的研究强调纳米皮肤病学,将纳米技术专门应用于皮肤病学,作为解决持续挑战的潜在解决方案,如提高治疗效果,减少全身毒性,以及实现精确的皮肤病学干预将这些创新转化为日常实践引发了关键的伦理、安全和公平问题。
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引用次数: 0
Skin cancer and human immunodeficiency virus. 皮肤癌和人类免疫缺陷病毒。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-10-09 DOI: 10.1016/j.clindermatol.2025.09.014
Cory Kosche, Martin Tw Chio, Sarah T Arron

The risk of skin cancer in persons living with HIV (PLWH) is an evolving subject area shaped by the use of antiretroviral therapy. Keratinocyte carcinomas, including basal and squamous cell carcinoma, have a high incidence in the general population and in PLWH. PLWH may have a higher risk of squamous cell carcinoma compared to the general population. In addition, Merkel cell carcinoma and sebaceous carcinoma exhibit higher incidence rates in PLWH. Data on melanoma risk are varied. Risks of skin cancer may be influenced by vigilant surveillance, photosensitivity, and immune status. Screening for skin cancer is generally recommended, although national guidelines vary in specific recommendations. Treatments range from topical therapies to surgeries to immune checkpoint inhibitors, with Mohs micrographic surgery playing an important role. Data on immune checkpoint inhibitors suggest safe and efficacious use in PLWH, although larger trials are warranted. The dynamic interplay between HIV, antiretroviral use and immunosuppression, and the risk and treatment of skin cancer underscores the importance of rigorous research studies and screening and treatment guidelines specific to this population.

艾滋病毒感染者(PLWH)患皮肤癌的风险是由抗逆转录病毒治疗的使用形成的一个不断发展的主题领域。角化细胞癌,包括基底细胞癌和鳞状细胞癌,在普通人群和PLWH中发病率很高。与一般人群相比,PLWH可能有更高的鳞状细胞癌风险。此外,默克尔细胞癌和皮脂腺癌在PLWH中发病率更高。关于黑色素瘤风险的数据各不相同。皮肤癌的风险可能受到警惕监视、光敏性和免疫状态的影响。一般建议进行皮肤癌筛查,尽管国家指南在具体建议方面有所不同。治疗范围从局部治疗到手术再到免疫检查点抑制剂,莫氏显微摄影手术起着重要作用。免疫检查点抑制剂的数据表明在PLWH中使用安全有效,尽管需要更大规模的试验。艾滋病毒、抗逆转录病毒使用和免疫抑制与皮肤癌的风险和治疗之间的动态相互作用强调了严格的研究和针对这一人群的筛查和治疗指南的重要性。
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引用次数: 0
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Clinics in dermatology
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