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Monocytic papulosis: A clonal mature monocyte-derived dendritic cell histiocytopathy of potentially diverse monocyte-derived dendritic cell phenotypes as a reflection of underlying chronic myeloproliferative disease 单核细胞丘疹病:一种克隆性成熟单核细胞来源的树突状细胞组织细胞病,具有潜在的多种单核细胞来源的树突状细胞表型,反映了潜在的慢性骨髓增生性疾病。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.09.027
Tiffany Liu BS , Taylor Kalomeris DO , Cynthia Magro MD
Clonal histiocytopathy involving non-Langerhans mature, monocyte-derived dendritic cells is a poorly characterized cutaneous manifestation of chronic myeloproliferative diseases. We describe the clinical and histopathological features of a well-differentiated histiocytopathy composed of mature, CD1a-negative, S100-negative, langerin-negative monocyte-derived dendritic cells, proposing it as a potential dermatologic marker for acute and/or chronic myeloproliferative diseases. This case series includes two cases and a review of eight others from the Weill Cornell Medicine Dermatopathology database from 2016 to 2024. Formalin-fixed tissue underwent immunohistochemical and histologic analyses for monocyte-derived dendritic cell markers. Primarily middle-aged to older men, the patients presented with papular-nodular eruptions associated with chronic myeloproliferative disease, either predating or after diagnosis, except in one case related to acute myeloid leukemia. The majority of cases exhibited a protracted, waxing-waning course. Histologic analysis revealed perivascular and periadnexal well-differentiated monocytic infiltrates with a dendritic cell phenotype expressing CD4, CD14, CD11c, and occasionally CD123, myxovirus resistance protein A, and granzyme, suggesting a myeloid dendritic cell phenotype in select cases. We termed this eruption “monocytic papulosis.” The limited sample size and followup require further research to evaluate the prognostic value of this eruption; it does not appear to correlate with an early indicator of aggressive myeloproliferative disease. Monocytic papulosis appears to represent a distinctive dermatologic manifestation associated with clonal acute and/or chronic myeloproliferative diseases.
克隆性组织细胞病变涉及非朗格汉斯成熟的单核细胞来源的树突状细胞,是慢性骨髓增生性疾病的一种特征不明确的皮肤表现。我们描述了一种分化良好的组织细胞病变的临床和组织病理学特征,该病变由成熟的、cd1a阴性的、s100阴性的、langerin阴性的单核细胞来源的树突状细胞组成,提出了它作为急性和/或慢性骨髓增生性疾病的潜在皮肤病标志物。本病例系列包括两个病例和对2016年至2024年威尔康奈尔医学皮肤病理学数据库中其他八个病例的回顾。对福尔马林固定组织进行免疫组织化学和组织学分析,检测单核细胞来源的树突状细胞标记物。主要影响中老年男性,患者在诊断前或诊断后表现为与慢性骨髓增生性疾病相关的丘疹-结节性爆发,除了一例与急性髓性白血病相关的病例。大多数病例表现出一个长期的、时断时续的过程。组织学分析显示,血管周围和附件周围分化良好的单核细胞浸润具有表达CD4、CD14、CD11c,偶尔表达CD123、MxA和颗粒酶的树突状细胞表型,表明在某些病例中存在髓样树突状细胞表型。我们称这种爆发为“单核细胞丘疹病”。有限的样本量和随访需要进一步的研究来评估这种爆发作为侵袭性骨髓增生性疾病的早期指标的预后价值。尽管如此,单核细胞丘疹病似乎是一种与克隆性急性和/或慢性骨髓增生性疾病相关的独特皮肤病表现。
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引用次数: 0
The impact and ethical consequences of tuition-free medical schools on improving diversity in health care 免学费医学院对改善医疗保健多样性的影响和伦理后果。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.05.018
Albert E. Zhou MD, PhD , Trevor Sutton MD, MBA , Jeffrey Hines MD , Steven Angus MD , Hao Feng MD, MHS , Brett Sloan MD , Jane M. Grant-Kels MD
Tuition-free medical education has been promoted as a solution to rising student debt and a strategy to improve diversity in the physician workforce. Several institutions across the United States have implemented full-tuition scholarships with the stated aim of increasing access, encouraging primary care careers, and reducing health care disparities; however, early evidence suggests that these initiatives may have unintended consequences.
We examine the ethical impact of tuition-free medical education on diversity and specialty choice. To realize the full potential of tuition-free education, policies must be coupled with need-based support, expanded public funding, and holistic admissions practices. Institutions should critically evaluate how their missions, resources, and partnerships promote equitable access. Despite its positive intentions, tuition-free models risk benefiting the already privileged and widening the gap they were designed to close.
免学费医学教育作为解决学生债务上升和提高医生队伍多样性的一种策略而得到推广。美国的一些机构已经实施了全额学费奖学金,其目的是增加获得机会,鼓励初级保健职业,减少医疗保健差距;然而,早期证据表明,这些举措可能会产生意想不到的后果。我们研究了免学费医学教育对多样性和专业选择的伦理和影响。为了充分发挥免学费教育的潜力,政策必须与基于需求的支持、扩大公共资金和整体招生实践相结合。各机构应审慎评估其使命、资源和伙伴关系如何促进公平获取。尽管有积极的意图,但免学费模式有可能使已经享有特权的人受益,并扩大它们原本旨在缩小的差距。
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引用次数: 0
Historic perspectives of prurigo nodularis 结节性痒疹的历史观察。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.09.029
Michael Joseph Diaz BS , Ivelina Kioutchoukova BS , Michael Joseph Lavery MD
Prurigo nodularis (PN) manifests as a chronic inflammatory skin disease characterized by the development of highly pruritic nodules. It is often accompanied by a variety of skin, metabolic, neurologic, and psychiatric comorbidities. A wealth of observational evidence indicates that PN disproportionately impacts non-White individuals, leading to a range of lasting, detrimental effects on patient quality of life and mental health. Despite its clinical significance, the underlying pathophysiologic mechanisms of PN remain elusive, contributing to the limited efficacy of existing therapeutics such as topical corticosteroids, phototherapy, and systemic treatments. A significant milestone was achieved when the US Food and Drug Administration-approved “Dupixent” (dupilumab), a human monoclonal IgG4 antibody targeting interleukin-4 and interleukin-13, as the first and only treatment for PN in adults. Nevertheless, persistent pruritus and the appearance of lesions continue to severely disrupt daily activities, sleep quality, and psychologic well-being. Given the urgent and unmet need for more effective management and general awareness, we review key historical developments in the literature and summarize pipeline therapies for this debilitating condition.
结节性痒疹(PN)表现为一种慢性炎症性皮肤病,其特征是产生高度瘙痒性结节。它通常伴有各种皮肤、代谢、神经和精神合并症。大量观察证据表明,PN对非白人个体的影响不成比例,导致一系列对患者生活质量和心理健康的持久有害影响。尽管其具有临床意义,但其潜在的病理生理机制仍然难以捉摸,这导致现有治疗方法(如局部皮质类固醇、光疗和全身治疗)的疗效有限。当美国食品和药物管理局(FDA)批准Dupixent (dupilumab),一种靶向IL-4和IL-13的人单克隆IgG4抗体作为成人PN的首个也是唯一治疗方法时,取得了一个重要的里程碑。持续的瘙痒和病变的出现继续严重扰乱日常活动,睡眠质量和心理健康。我们回顾了关键的历史发展,并总结了这种衰弱性疾病的管道治疗方法。
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引用次数: 0
Clinical, histopathologic, and immunohistochemical patterns of cutaneous leishmaniasis 临床、组织病理。皮肤利什曼病的免疫组织化学模式。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.09.025
Saul Turcios Escobar MD , Vesna Petronic-Rosic MD, MSc, MBA
Leishmaniasis is an intracellular parasitic infection whose life cycle involves two different hosts: a female sandfly and mammals (including humans and dogs). The initial lesion develops after the bite of an infected sandfly. Usually, it is a solitary papule that ulcerates with a raised border. We describe four cases with clinical manifestations, histopathological/immunohistochemical patterns, and outcomes. All biopsies were stained with hematoxylin and eosin, Giemsa, Grocott methenamine silver, periodic acid–Schiff, Gram, and acid-fast bacillus and submitted for polymerase chain reaction (PCR). The patients’ mean age at diagnosis was 35 years; all were men who had immigrated to the United States by walking through the Amazon jungle in South America. Microscopy revealed a mixed infiltrate in the dermis. Amastigotes were visible in histiocytes and vacuoles and were highlighted by the Giemsa stain. The lesions were successfully treated with amphotericin B for seven days in four patients; the fourth was lost to followup. The diagnosis of cutaneous leishmaniasis was made based on clinical presentation, biopsy, and PCR results, when available. Leishmaniasis is a major public health problem. Globally, it is among the top 10 neglected tropical diseases, with >12 million people infected worldwide.
Leishmania is a protozoan parasite transmitted by female sandflies that creates a neglected tropical disease according to the World Health Organization. It is a major public concern due to its consequences on health, especially in people with socioeconomic difficulties. There are three main clinical forms: (1) localized cutaneous leishmaniasis (CL); (2) mucocutaneus leishmaniasis; and (3) visceral leishmaniasis. The eight countries contributing to 90% of the cases are Afghanistan, Algeria, Brazil, Iran, Pakistan, Peru, Saudi Arabia, and Syria.1
利什曼病是一种细胞内寄生虫感染,其生命周期涉及两个不同的宿主:雌性白蛉和哺乳动物(包括人类和狗)。最初的病变是在被感染的白蛉叮咬后出现的。通常,它是一个孤立的丘疹,溃疡与凸起的边界。我们描述了四个病例的临床表现,组织病理/免疫组织化学模式和结果。
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引用次数: 0
Potpourri V: Dermatology at the crossroads of science, society, and history 百花香5:皮肤病学在科学,社会和历史的十字路口。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.09.019
Vesna Petronic-Rosic MD, MSc, MBA , Franco Rongioletti MD , Leonard J. Hoenig MD
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引用次数: 0
The impact of social media on patient behavior in aesthetic treatments: Decreased influence on patients at a reference center for aesthetic ultrasonography 社交媒体对美容治疗中患者行为的影响:在美容超声检查参考中心对患者的影响降低。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.10.005
Claudia Gonzalez MD , Juan Luis Martinez-Gonzalez , George Kroumpouzos MD, PhD
Social media (SM) has a significant impact on the public awareness of dermatologic conditions, as well as the perception of beauty and aesthetic pursuits of patients; however, they increase the risk of self-diagnosis and misinterpretation of clinical conditions as aesthetic ones. We discuss the risks of self-diagnosis, including delays in proper diagnosis or complications in treatment due to not seeking specific dermatologic assessment promptly, with tools such as high-resolution ultrasound. We specifically examined how SM influences patient behavior in aesthetic medicine by focusing on a group of patients seeking high-resolution ultrasound for diagnostic or aesthetic reasons at a specialized center for aesthetic ultrasonography. A total of 140 respondents (115 women, or 82.14%) completed a survey assessing their behaviors and attitudes related to SM. Among these, 37 respondents (26.4%) sought ultrasonography for aesthetic-related reasons. Interestingly, 66.43% of the participants reported having minimal or no influence from SM in their decision to undergo an aesthetic procedure, whereas only 19.29% felt moderately or highly influenced by SM. These findings suggest that our group of patients experienced less influence from SM compared with studies conducted on the general population. This difference may be attributed to the fact that most participants were referred by a dermatologist or surgeon, thus their access to dermatologic information was directly influenced by these professionals. Dermatologists should actively counter misinformation in clinical settings by ensuring clear communication to reduce patient misconceptions and educate them about the limitations of SM.
社交媒体(SM)对公众对皮肤病的认识,以及患者对美的感知和审美追求产生了重大影响;然而,它们增加了自我诊断的风险,并将临床状况误解为审美问题。我们讨论了自我诊断的风险,包括由于没有及时寻求特定的皮肤病学评估而导致的正确诊断的延误或治疗的并发症,如高分辨率超声。我们专门研究了SM如何影响患者在美容医学中的行为,通过关注一组在美容超声检查专业中心寻求高分辨率超声诊断或美学原因的患者。共有140名受访者(115名女性,占82.14%)完成了一项评估他们与SM相关的行为和态度的调查。其中,37人(26.4%)因美观原因寻求超声检查。有趣的是,66.43%的参与者报告SM对他们决定接受美容手术的影响很小或没有影响,而只有19.29%的人认为SM对他们的影响中等或高度。这些发现表明,与在一般人群中进行的研究相比,我们的患者组受到SM的影响较小。这种差异可能是由于大多数参与者是由皮肤科医生或外科医生介绍的,因此他们对皮肤科信息的获取直接受到这些专业人士的影响。皮肤科医生应积极应对临床环境中的错误信息,确保清晰的沟通,以减少患者的误解,并教育他们SM的局限性。
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引用次数: 0
The skincare craze among tweens: Ethical and dermatologic implications of social media beauty trends 青少年的护肤热潮:社交媒体美容趋势的伦理和皮肤病学含义。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.02.009
Rachel Wetstone MD, MPH , Jane M. Grant-Kels MD
The rise of social media has significantly influenced how younger generations engage with skincare, exposing them to trends that may not be developmentally appropriate. Platforms such as TikTok have fueled the popularity of skincare among tweens, leading to increased use of products often unsuitable for their skin. This trend has raised ethical concerns about (1) transparency and informed consent, (2) premature and inappropriate beauty standards, and (3) financial exploitation. Dermatologists report an increase in the number of young patients experiencing adverse skin reactions due to inappropriate product use, although mental health professionals note growing anxiety related to beauty dysmorphia. The lack of regulation leaves young consumers vulnerable. Addressing this issue requires collaboration among parents, educators, dermatologists, and influencers to promote responsible skincare education and ethical marketing. Stricter oversight and informed guidance are essential to ensuring young consumers develop healthy, age-appropriate skincare habits.
社交媒体的兴起极大地影响了年轻一代的护肤方式,让他们接触到可能不适合他们发育的潮流。抖音等平台推动了护肤品在青少年中的流行,导致不适合他们皮肤的产品的使用增加。这一趋势引发了伦理方面的担忧:1)透明度和知情同意;2)过早和不恰当的审美标准;3)经济剥削。皮肤科医生报告说,由于使用不当的产品,越来越多的年轻患者出现了皮肤不良反应,而心理健康专家则注意到,与美容畸形有关的焦虑情绪日益增加。缺乏监管使年轻消费者易受伤害。解决这个问题需要家长、教育者、皮肤科医生和有影响力的人之间的合作,以促进负责任的护肤教育和道德营销。严格的监督和知情的指导对于确保年轻消费者养成健康、适合年龄的护肤习惯至关重要。
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引用次数: 0
Dermatology publishing revenues and reviewer compensation: A data-driven study 皮肤病出版收入和审稿人报酬:一项数据驱动的研究。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.07.007
Waseem Hassan PhD , Fred Paas PhD
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引用次数: 0
Diseases named after fictional characters and celebrities 以虚构人物和名人命名的疾病。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.10.002
Uwe Wollina MD , Leonard J. Hoenig MD , Lawrence Charles Parish MD, MD (Hon), FRCP (Edin)
Medical eponyms originate from various sources. Wee report the medical eponyms referring to either mystical or fictional characters, as well as celebrities. We have included some background on the diseases and the persons behind the eponyms, covering a broad range from Greek goddesses to biblical saints, as well as royals, fictional literary characters, and film and theater celebrities. We have provided a unique view on how medical science, culture, and society influence each other.
医学名词的来源多种多样。在这篇综述中,我们报道了与神秘人物或虚构人物以及名人有关的医学名字。我们已经包括了一些关于疾病的背景和名字背后的人,涵盖了从希腊女神到圣经圣徒,以及皇室,虚构的文学人物,电影和戏剧名人。我们为医学科学、文化和社会如何相互影响提供了独特的视角。
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引用次数: 0
Dermatology-related disorders named after patients 以患者命名的皮肤病相关疾病。
IF 2.2 4区 医学 Q2 DERMATOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.clindermatol.2025.09.002
Leonard J. Hoenig MD , Uwe Wollina MD , Lawrence Charles Parish MD, MD (Hon), FRCP (Edin)
This contribution presents 14 dermatology-related eponyms that honor the patients who helped to define the clinical entities and disorders that bear their names or initials. These clinical entities and disorders include: (1) anti-La antibodies, (2) anti-Ro antibodies, (3) anti-Sm antibodies, (4) B-K mole syndrome, (5) HeLa cells, (6) Carrion disease, (7) Christmas disease, (8) Cowden syndrome, (9) Hageman disease, (10) Hartnup disease, (11) Mortimer malady, (12) rickettsiosis, (13) Schamroth sign, and (14) Trousseau syndrome.
这一贡献提出了14个皮肤病学相关的名字,以纪念那些帮助定义临床实体和疾病的患者,他们的名字或首字母缩写。这些临床实体和疾病包括:1)抗la抗体,2)抗ro抗体,3)抗sm抗体,4)B-K痣综合征,5)海拉细胞,6)腐肉病,7)圣诞病,8)考登综合征,9)哈格曼病,10)哈特纳普病,11)莫蒂默病,12)立克次体病,13)沙姆罗斯氏征,14)特鲁索综合征。
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引用次数: 0
期刊
Clinics in dermatology
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