Pub Date : 2020-01-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2020.01.016
Lei Zhang
Objective To observe the difference of the clinical effect of using high-strength woven suture or not in the reconstruction of posterior cruciate ligament (PCL) with single tendon autograft under arthroscope. Methods The clinical data of 40 patients with posterior cruciate ligament rupture and ligament reconstruction admitted to Shengjing Hospital Affiliated to China Medical University from 2017 to 2018 were analyzed retrospectively.According to whether or not to add Arthrex ar-7200 (Arthrex, Naples, FL, USA) braided suture in the autogenous hamstring graft, the patients were divided into test group (17 cases) and control group (23 cases). The posterior drawer test (PDT) was used as the knee joint stability test to evaluate the knee function, IKDC score, Lysholm score and Tegner score were used as the evaluation criteria.The evaluation results of the knee joint in the experimental group and the control group were compared before and one year after the operation, and the evaluation results of the knee joint in the two groups were compared one year after the operation and one year before the operation Results Functional aspects of knee joint: The Lysholm score of the experimental group was expressed by median (quartile) 1 year before and after operation.Lysholm scores of the trail group were 64 (40, 81) and 84 (73, 87) preoperative and postoperative, respectively, the control group were 68 (48, 78) and 80 (70, 90) respectively, there was statistically difference before and after surgery (Z value was -2.535 and -3.576, P value was 0.011 and 0.05). The Tegner score of the experimental group before and 1 year after operation was expressed as the median [quartile], which was 2.0 (1.0, 2.5), 6.0 (5.0, 7.5) respectively, and that of the control group was 2.0 (1.0, 3.0), 6.0 (4.0, 7.0) respectively.There was statistically significant difference between the two groups before and after operation (Z value was -3.397, -4.122, all P 0.05). One year after operation, the IKDC scores of the two groups were significantly improved (Z values were -3.750, -4.234, all P 0.05). There was no significant difference between the two groups in the postoperative drawer test (P>0.05); one year after the operation, the stability of the two groups was significantly improved (Z values were -3.674, -4.083, all P<0.01), and the stability of the experimental group was significantly better than that of the control group(Z=0.156, P=0.039). Conclusion Posterior cruciate ligament reconstruction with autologous hamstring muscle can achieve satisfactory clinical results, and placing high-strength braided sutures in the graft is more conducive to the recovery of knee joint stability. Key words: Posterior cruciate ligament; Ligament reconstruction; Arthroscopy; Autogenous hamstring tendon
{"title":"A clinical comparative study on the reconstruction of posterior cruciate ligament with single tendon autograft plus high-strength braid or not","authors":"Lei Zhang","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.01.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.01.016","url":null,"abstract":"Objective To observe the difference of the clinical effect of using high-strength woven suture or not in the reconstruction of posterior cruciate ligament (PCL) with single tendon autograft under arthroscope. Methods The clinical data of 40 patients with posterior cruciate ligament rupture and ligament reconstruction admitted to Shengjing Hospital Affiliated to China Medical University from 2017 to 2018 were analyzed retrospectively.According to whether or not to add Arthrex ar-7200 (Arthrex, Naples, FL, USA) braided suture in the autogenous hamstring graft, the patients were divided into test group (17 cases) and control group (23 cases). The posterior drawer test (PDT) was used as the knee joint stability test to evaluate the knee function, IKDC score, Lysholm score and Tegner score were used as the evaluation criteria.The evaluation results of the knee joint in the experimental group and the control group were compared before and one year after the operation, and the evaluation results of the knee joint in the two groups were compared one year after the operation and one year before the operation Results Functional aspects of knee joint: The Lysholm score of the experimental group was expressed by median (quartile) 1 year before and after operation.Lysholm scores of the trail group were 64 (40, 81) and 84 (73, 87) preoperative and postoperative, respectively, the control group were 68 (48, 78) and 80 (70, 90) respectively, there was statistically difference before and after surgery (Z value was -2.535 and -3.576, P value was 0.011 and 0.05). The Tegner score of the experimental group before and 1 year after operation was expressed as the median [quartile], which was 2.0 (1.0, 2.5), 6.0 (5.0, 7.5) respectively, and that of the control group was 2.0 (1.0, 3.0), 6.0 (4.0, 7.0) respectively.There was statistically significant difference between the two groups before and after operation (Z value was -3.397, -4.122, all P 0.05). One year after operation, the IKDC scores of the two groups were significantly improved (Z values were -3.750, -4.234, all P 0.05). There was no significant difference between the two groups in the postoperative drawer test (P>0.05); one year after the operation, the stability of the two groups was significantly improved (Z values were -3.674, -4.083, all P<0.01), and the stability of the experimental group was significantly better than that of the control group(Z=0.156, P=0.039). Conclusion Posterior cruciate ligament reconstruction with autologous hamstring muscle can achieve satisfactory clinical results, and placing high-strength braided sutures in the graft is more conducive to the recovery of knee joint stability. Key words: Posterior cruciate ligament; Ligament reconstruction; Arthroscopy; Autogenous hamstring tendon","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69921028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2020.01.011
Zhiqiang Li, Yonghua Fu, Zhong Zhu
Objective To evaluate the relationships between admission fasting serum C-peptide concentration and cardiac function status in chronic heart failure (CHF) patients with or without diabetes. Methods From July 2017 to December 2018, 262 CHF patients with or without diabetes in the Department of Cardiology of Pudong hospital in Shanghai were analyzed.Their cardiac function was classified as New York Heart Association (NYHA) grade Ⅱ to Ⅳ, and they were divided into diabetes group (80 cases) and non diabetes group (182 cases). At the same time, 62 subjects without diabetes and heart disease were randomly selected as the control group.To analyze the relationship between fasting serum C-peptide level and cardiac function in diabetic and nondiabetic CHF patients. Results (1)The fasting plasma glucose and serum C-peptide concentrations of diabetes group paitents were(8.7±2.9) mmol/L and(0.78±0.67) nmol/L respectively, the nondiabetes group paitents were(5.8±1.67) mmol/L and(0.56±0.61)nmol/L respectively, the control group were(5.1±0.69) mmol/L and(0.16±0.12)nmol/L respectively.The difference in the three groups was statistically significant(all P 0.05). (2) In all patients with heart failure, diabetes mellitus and non diabetes heart failure, the levels of serum C-peptide were (1.05±0.85), (1.17±0.82), (0.99±0.86) nmol/L in NYHA Ⅳ group, and (0.53±0.22), (0.52±0.20), (0.54±0.23) nmol/L in NYHA Ⅲ group, and (0.32±0.09), (0.32±0.11), (0.31±0.09) nmol/L in NYHA Ⅱ group.After adjustment of age, gender, smoking, insulin secretion and hypoglycemic drugs, body mass index, blood pressure, total bilirubin (TBIL), alanine aminotransferase (ALT), creatinine, blood glucose, blood lipid, white blood cell count (WBC) and hemoglobin level by covariance analysis, all patients with heart failure The level of serum C-peptide in NYHA Ⅳ group was significantly higher than that in Ⅲ group (all P 0.05) (3) Using multiple linear regression analysis, the adjustment factors included age, gender, smoking, BMI, blood pressure, TBIL, alt, creatinine, blood glucose, blood lipid, WBC and hemoglobin levels.The results showed that the serum C-peptide level was positively correlated with pro-BNP in all patients with heart failure, diabetes and non diabetes heart failure (β: 0.006, 95%CI -0.016-0.028 , P=0.007; β: 0.117, 95%CI-0.042-0.277 , P=0.006; β: 0.411, 95%CI-0.149-0.971 , P=0.023), negatively correlated with LVEF(β: -0.122, 95%CI-0.285-0.041, P=0.004; β: -0.008, 95%CI-0.032-0.016, P=0.010; β: -0.065, 95%CI-0.139-0.011, P=0.036). Conclusion The level of fasting serum C-peptide was significantly increased in patients with CHF and non-diabetic patients, and was related to the severity of heart failure. Key words: Chronic heart failure; Diabetes mellitus; Serum C-peptide; N-terminal B-type natriuretic peptide; Cardiac function
目的探讨合并或不合并糖尿病的慢性心力衰竭(CHF)患者入院时空腹血清c肽浓度与心功能状态的关系。方法对2017年7月至2018年12月上海市浦东医院心内科收治的262例合并或不合并糖尿病的CHF患者进行分析。心功能按照纽约心脏协会(NYHA)分级Ⅱ~Ⅳ，分为糖尿病组(80例)和非糖尿病组(182例)。同时，随机选取62名无糖尿病、无心脏病的受试者作为对照组。分析糖尿病和非糖尿病性CHF患者空腹血清c肽水平与心功能的关系。结果(1)糖尿病组空腹血糖和血清c肽浓度分别为(8.7±2.9)mmol/L和(0.78±0.67)nmol/L，非糖尿病组空腹血糖和血清c肽浓度分别为(5.8±1.67)mmol/L和(0.56±0.61)nmol/L，对照组空腹血糖和血清c肽浓度分别为(5.1±0.69)mmol/L和(0.16±0.12)nmol/L。三组间差异均有统计学意义(P < 0.05)。(2)所有心力衰竭、糖尿病及非糖尿病心力衰竭患者血清c肽水平，NYHAⅣ组分别为(1.05±0.85)、(1.17±0.82)、(0.99±0.86)nmol/L, NYHAⅢ组分别为(0.53±0.22)、(0.52±0.20)、(0.54±0.23)nmol/L, NYHAⅡ组分别为(0.32±0.09)、(0.32±0.11)、(0.31±0.09)nmol/L。经协方差分析调整年龄、性别、吸烟、胰岛素分泌及降糖药、体重指数、血压、总胆红素(TBIL)、丙氨酸转氨酶(ALT)、肌酐、血糖、血脂、白细胞计数(WBC)、血红蛋白水平后，所有心衰患者血清c肽水平NYHAⅣ组显著高于Ⅲ组(P均为0.05)(3)采用多元线性回归分析，调整因素包括年龄、性别、吸烟、BMI、血压、TBIL、alt、肌酐、血糖、血脂、白细胞、血红蛋白水平。结果显示，所有心力衰竭、糖尿病和非糖尿病心力衰竭患者血清c肽水平与前bnp均呈正相关(β: 0.006, 95%CI -0.016-0.028, P=0.007;β: 0.117, 95%ci-0.042-0.277, p =0.006;β: 0.411, 95% ci -0.149 ~ 0.971, P=0.023)，与LVEF呈负相关(β: -0.122, 95% ci -0.285 ~ 0.041, P=0.004;β: -0.008, 95%ci-0.032-0.016, p =0.010;β: -0.065, 95%ci-0.139-0.011, p =0.036)。结论CHF患者和非糖尿病患者空腹血清c肽水平明显升高，且与心力衰竭的严重程度有关。关键词:慢性心力衰竭;糖尿病;血清c -肽;n端b型利钠肽;心脏功能
{"title":"Relationship between fasting serum C-peptide level and heart function in patients with or without diabetes mellitus and chronic heart failure","authors":"Zhiqiang Li, Yonghua Fu, Zhong Zhu","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.01.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.01.011","url":null,"abstract":"Objective To evaluate the relationships between admission fasting serum C-peptide concentration and cardiac function status in chronic heart failure (CHF) patients with or without diabetes. Methods From July 2017 to December 2018, 262 CHF patients with or without diabetes in the Department of Cardiology of Pudong hospital in Shanghai were analyzed.Their cardiac function was classified as New York Heart Association (NYHA) grade Ⅱ to Ⅳ, and they were divided into diabetes group (80 cases) and non diabetes group (182 cases). At the same time, 62 subjects without diabetes and heart disease were randomly selected as the control group.To analyze the relationship between fasting serum C-peptide level and cardiac function in diabetic and nondiabetic CHF patients. Results (1)The fasting plasma glucose and serum C-peptide concentrations of diabetes group paitents were(8.7±2.9) mmol/L and(0.78±0.67) nmol/L respectively, the nondiabetes group paitents were(5.8±1.67) mmol/L and(0.56±0.61)nmol/L respectively, the control group were(5.1±0.69) mmol/L and(0.16±0.12)nmol/L respectively.The difference in the three groups was statistically significant(all P 0.05). (2) In all patients with heart failure, diabetes mellitus and non diabetes heart failure, the levels of serum C-peptide were (1.05±0.85), (1.17±0.82), (0.99±0.86) nmol/L in NYHA Ⅳ group, and (0.53±0.22), (0.52±0.20), (0.54±0.23) nmol/L in NYHA Ⅲ group, and (0.32±0.09), (0.32±0.11), (0.31±0.09) nmol/L in NYHA Ⅱ group.After adjustment of age, gender, smoking, insulin secretion and hypoglycemic drugs, body mass index, blood pressure, total bilirubin (TBIL), alanine aminotransferase (ALT), creatinine, blood glucose, blood lipid, white blood cell count (WBC) and hemoglobin level by covariance analysis, all patients with heart failure The level of serum C-peptide in NYHA Ⅳ group was significantly higher than that in Ⅲ group (all P 0.05) (3) Using multiple linear regression analysis, the adjustment factors included age, gender, smoking, BMI, blood pressure, TBIL, alt, creatinine, blood glucose, blood lipid, WBC and hemoglobin levels.The results showed that the serum C-peptide level was positively correlated with pro-BNP in all patients with heart failure, diabetes and non diabetes heart failure (β: 0.006, 95%CI -0.016-0.028 , P=0.007; β: 0.117, 95%CI-0.042-0.277 , P=0.006; β: 0.411, 95%CI-0.149-0.971 , P=0.023), negatively correlated with LVEF(β: -0.122, 95%CI-0.285-0.041, P=0.004; β: -0.008, 95%CI-0.032-0.016, P=0.010; β: -0.065, 95%CI-0.139-0.011, P=0.036). Conclusion The level of fasting serum C-peptide was significantly increased in patients with CHF and non-diabetic patients, and was related to the severity of heart failure. Key words: Chronic heart failure; Diabetes mellitus; Serum C-peptide; N-terminal B-type natriuretic peptide; Cardiac function","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69921291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.06.006
Aidong Liu, Shifei Liu, Jinhui Pang, Feng Yan
Objective To detect and analyze the expression and significance of olfactory receptor family 2 subfamily W member 3 (OR2W3) in gastric adenocarcinoma, and to explore its correlation with cell proliferation and apoptosis. Methods From January 2013 to June 2014, 61 patients with gastric adenocarcinoma diagnosed in the Affiliated Hospital of North China University of Technology and undergoing radical operation were selected as the study subjects.Neoplasm tissue were selected as the observation group, normal gastric mucosa(61 cases) were selected as the control group.Immunohistochemistry was used to detect the expression of or2w3 and HER-2 in the two groups.Fish was used to detect the amplification of HER-2 gene in some of the patients with uncertain expression of HER-2.Western blot was used to detect the expression of PCNA and BAX in the observation group. Results Positive rate of OR2W3 was higher in the observation group(50.8%, 31/61) than that in the control group(8.2%(5/61)), and the difference between the two groups was statistically significant(χ2=26.63, P<0.05). The difference of the positive rate of OR2W3 in the maximum diameter(≥6 cm was 68.8%(22/32), <6 cm was 31.0%(9/29)), depth of invasion(seroas and beyond was 63.4%(26/41), less serosa was 25.0%(5/20)), vascular and lymphatic vessel involvement(involvement was 78.6%(11/14), no involvement was 42.6%(20/47)), lymph node metastasis(metastasis was 82.1%(23/28), no metastasis was 24.2%(3/33)) and TNM staging(Ⅲ+ Ⅳ was 78.1%(25/32), Ⅰ+ Ⅱ was 20.7%(6/29)) in observation group was statistically significant(χ2 was 8.423, 7.937, 5.559, 20.318, 20.080, respectively, all P<0.05). Expression of OR2W3 was correlated with survival time(X2=5.31, P<0.05). Positive correlation was found between OR2W3 and PCNA expression(r=0.54, P<0.05). Negative correlation were found between OR2W3 and BAX expression(r=-0.59, P<0.05). There were 8 cases of HER-2 positive and 53 cases of HER-2 negative.The difference of OR2W3 expression in tumors with different HER-2 expression was statistically significant (χ2=4.957, P<0.05). Conclusion The expression of OR2W3 in gastric adenocarcinoma tissue is significantly increased, which can promote the proliferation of cancer cells and inhibit apoptosis.OR2W3 is related to HER-2 expression.Detection of OR2W3 expression may be of some value in judging prognosis. Key words: Gastric adenocarcinoma; OR2W3; Proliferation; Apoptosis; Prognosis
{"title":"Expression and significance of OR2W3 in gastric adenocarcinoma","authors":"Aidong Liu, Shifei Liu, Jinhui Pang, Feng Yan","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.06.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.06.006","url":null,"abstract":"Objective \u0000To detect and analyze the expression and significance of olfactory receptor family 2 subfamily W member 3 (OR2W3) in gastric adenocarcinoma, and to explore its correlation with cell proliferation and apoptosis. \u0000 \u0000 \u0000Methods \u0000From January 2013 to June 2014, 61 patients with gastric adenocarcinoma diagnosed in the Affiliated Hospital of North China University of Technology and undergoing radical operation were selected as the study subjects.Neoplasm tissue were selected as the observation group, normal gastric mucosa(61 cases) were selected as the control group.Immunohistochemistry was used to detect the expression of or2w3 and HER-2 in the two groups.Fish was used to detect the amplification of HER-2 gene in some of the patients with uncertain expression of HER-2.Western blot was used to detect the expression of PCNA and BAX in the observation group. \u0000 \u0000 \u0000Results \u0000Positive rate of OR2W3 was higher in the observation group(50.8%, 31/61) than that in the control group(8.2%(5/61)), and the difference between the two groups was statistically significant(χ2=26.63, P<0.05). The difference of the positive rate of OR2W3 in the maximum diameter(≥6 cm was 68.8%(22/32), <6 cm was 31.0%(9/29)), depth of invasion(seroas and beyond was 63.4%(26/41), less serosa was 25.0%(5/20)), vascular and lymphatic vessel involvement(involvement was 78.6%(11/14), no involvement was 42.6%(20/47)), lymph node metastasis(metastasis was 82.1%(23/28), no metastasis was 24.2%(3/33)) and TNM staging(Ⅲ+ Ⅳ was 78.1%(25/32), Ⅰ+ Ⅱ was 20.7%(6/29)) in observation group was statistically significant(χ2 was 8.423, 7.937, 5.559, 20.318, 20.080, respectively, all P<0.05). Expression of OR2W3 was correlated with survival time(X2=5.31, P<0.05). Positive correlation was found between OR2W3 and PCNA expression(r=0.54, P<0.05). Negative correlation were found between OR2W3 and BAX expression(r=-0.59, P<0.05). There were 8 cases of HER-2 positive and 53 cases of HER-2 negative.The difference of OR2W3 expression in tumors with different HER-2 expression was statistically significant (χ2=4.957, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The expression of OR2W3 in gastric adenocarcinoma tissue is significantly increased, which can promote the proliferation of cancer cells and inhibit apoptosis.OR2W3 is related to HER-2 expression.Detection of OR2W3 expression may be of some value in judging prognosis. \u0000 \u0000 \u0000Key words: \u0000Gastric adenocarcinoma; OR2W3; Proliferation; Apoptosis; Prognosis","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44705318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.06.021
Lili Deng, Xiaotong Zhao
Objective Metformin (MET) is the first-line medications of choice for patients with type 2 diabetes.In recent years, a large number of studies at home and abroad have shown that metformin not only has significant effects in controlling blood sugar level of diabetic patients and intervening in impaired glucose tolerance, but also has " magical" effects in in the field of hypoglycemic outside.In addition to the early discovery that metformin can be used to treat metabolic syndrome and polycystic ovary syndrome, control body weight, blood pressure, blood lipid, and reduce the risk of cardiovascular events, metformin can also play anti-tumor, anti-inflammatory effects, delay aging, and treat mental disorders such as depression.This article reviews the effect of metformin in the field out of hypoglycemic. Key words: Metformin; Neuropsychiatric disorders; Intestinal flora; Osteogenesis; Anti-inflammatory and anti-aging
{"title":"The latest research progress of metformin on the effect beyond hypoglycemic","authors":"Lili Deng, Xiaotong Zhao","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.06.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.06.021","url":null,"abstract":"Objective \u0000Metformin (MET) is the first-line medications of choice for patients with type 2 diabetes.In recent years, a large number of studies at home and abroad have shown that metformin not only has significant effects in controlling blood sugar level of diabetic patients and intervening in impaired glucose tolerance, but also has \" magical\" effects in in the field of hypoglycemic outside.In addition to the early discovery that metformin can be used to treat metabolic syndrome and polycystic ovary syndrome, control body weight, blood pressure, blood lipid, and reduce the risk of cardiovascular events, metformin can also play anti-tumor, anti-inflammatory effects, delay aging, and treat mental disorders such as depression.This article reviews the effect of metformin in the field out of hypoglycemic. \u0000 \u0000 \u0000Key words: \u0000Metformin; Neuropsychiatric disorders; Intestinal flora; Osteogenesis; Anti-inflammatory and anti-aging","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45014784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.06.018
Wenxue Ma
Objective To investigate the epidemiological characteristics and related risk factors of elderly patients with osteoporosis. Methods The basic data of 900 elderly people in Xining City from February 2015 to February 2018 were investigated.The proximal femur and L2~4 bone mineral density were measured by dual-energy X-ray absorptiometry.Osteoporosis was diagnosed and its epidemiological characteristics and risk factors were analyzed. Results Among the 900 elderly people in Xining, 276 had osteoporosis, 624 did not have osteoporosis, and the prevalence rate was 30.67%.There were significant differences in gender, body mass index, smoking, alcoholism, family history of osteoporosis between elderly people with osteoporosis and those without osteoporosis (all P<0.05). The incidence of osteoporosis was 26.63% (192/721), 47.41% (64/135) and 45.45% (20/44) in the elderly of Han nationality, Tibetan nationality and Hui nationality, respectively.The average bone density of femoral trochanter, bilateral femoral neck, Ward's triangle and L2~4 in the elderly of different age groups in Xining city was 2.63% (192/721). The prevalence of femoral trochanter, bilateral femoral neck, Ward_s triangle and L2~4 was lower in male elderly than in female elderly (all P<0.05). By logistic regression analysis, female(OR=2.573, 95%CI1.319~3.086), age growth(OR=3.076, 95%CI1.128~3.746), bad living habits(OR=1.796, 95%CI1.154~5.286) and family history of osteoporosis(OR=1.641, 95%CI1.128~4.376) were elderly in Xining.Risk factors of osteoporosis (all P<0.05). Conclusion The prevalence of osteoporosis in 900 elderly people in Xining City was 30.67%.With the increase of age, the bone mineral density of the elderly gradually decreased.The average bone mineral density of L2~4 was higher than that of proximal femur, and the average bone mineral density of females was lower than that of males.The occurrence of osteoporosis was attributed to females, age growth, bad living habits and family history of osteoporosis.Risk factors can provide reference for prevention and treatment of osteoporosis in the elderly in Xining. Key words: Osteoporosis; Elderly people; Epidemiology; Risk factors; Age; Gender; Ethnic group
{"title":"Epidemiological characteristics and related risk factors of elderly osteoporosis in Xining City","authors":"Wenxue Ma","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.06.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.06.018","url":null,"abstract":"Objective \u0000To investigate the epidemiological characteristics and related risk factors of elderly patients with osteoporosis. \u0000 \u0000 \u0000Methods \u0000The basic data of 900 elderly people in Xining City from February 2015 to February 2018 were investigated.The proximal femur and L2~4 bone mineral density were measured by dual-energy X-ray absorptiometry.Osteoporosis was diagnosed and its epidemiological characteristics and risk factors were analyzed. \u0000 \u0000 \u0000Results \u0000Among the 900 elderly people in Xining, 276 had osteoporosis, 624 did not have osteoporosis, and the prevalence rate was 30.67%.There were significant differences in gender, body mass index, smoking, alcoholism, family history of osteoporosis between elderly people with osteoporosis and those without osteoporosis (all P<0.05). The incidence of osteoporosis was 26.63% (192/721), 47.41% (64/135) and 45.45% (20/44) in the elderly of Han nationality, Tibetan nationality and Hui nationality, respectively.The average bone density of femoral trochanter, bilateral femoral neck, Ward's triangle and L2~4 in the elderly of different age groups in Xining city was 2.63% (192/721). The prevalence of femoral trochanter, bilateral femoral neck, Ward_s triangle and L2~4 was lower in male elderly than in female elderly (all P<0.05). By logistic regression analysis, female(OR=2.573, 95%CI1.319~3.086), age growth(OR=3.076, 95%CI1.128~3.746), bad living habits(OR=1.796, 95%CI1.154~5.286) and family history of osteoporosis(OR=1.641, 95%CI1.128~4.376) were elderly in Xining.Risk factors of osteoporosis (all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The prevalence of osteoporosis in 900 elderly people in Xining City was 30.67%.With the increase of age, the bone mineral density of the elderly gradually decreased.The average bone mineral density of L2~4 was higher than that of proximal femur, and the average bone mineral density of females was lower than that of males.The occurrence of osteoporosis was attributed to females, age growth, bad living habits and family history of osteoporosis.Risk factors can provide reference for prevention and treatment of osteoporosis in the elderly in Xining. \u0000 \u0000 \u0000Key words: \u0000Osteoporosis; Elderly people; Epidemiology; Risk factors; Age; Gender; Ethnic group","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41884669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.06.008
Xue-jiao Zhang, Qiaolan Zhou, Qingqiang Qian, Yanmin Kan
Objective To investigate clinical value of right ventricular morphology in children with congenital heart disease associated pulmonary hypertension. Methods From October 2014 to October 2017, 37 children with congenital heart disease without associated pulmonary hypertension (resting pulmonary systolic pressure ≤ 30 mmHg, 1 mmHg=0.133 kPa) were selected as group A. Thirty-seven children with congenital heart disease and associated pulmonary hypertension (resting pulmonary systolic pressure>30 m). were in group B, and 37 healthy children were in control group.Echocardiography was performed to compare the results of right ventricular morphology and systolic function in three groups. Results (1)Right ventricular morphology indexes: right atrium upper and lower diameter((56.8±4.0) mm), right atrium left and right diameter((49.2±3.3) mm), right ventricle basal segment inner diameter((43.7±2.5) mm), right ventricle medial diameter((41.7±3.9) mm), right ventricle long axis distance((73.4±6.2) mm), sternum sidelines right ventricular outflow tract proximal end diameter((37.8±2.4) mm), short axis view right ventricular outflow tract distal internal diameter((33.6±2.1) mm), main pulmonary artery internal diameter((30.5±2.5)mm), right ventricle end diastolic area((31.6±1.8) cm2), right ventricle end systolic area((19.0±2.7) cm2)in group B were higher than those in group A((46.2±3.1) mm, (40.4±2.8) mm, (34.6±2.2) mm, (32.5±2.6) mm, (65.1±4.7) mm, (30.2±2.0) mm, (29.4±1.8) mm, (23.0±1.6) mm, (22.5±1.1) cm2, (11.6±1.2) cm2)and control group((45.3±2.6) mm, (39.5±1.7) mm, (34.0±1.9) mm, (31.8±2.0) mm, (63.2±3.8) mm, (29.6±1.7) mm, (28.9±1.5) mm, (22.4±1.4) mm, (22.1±1.0) cm2, (11.3±0.9) cm2), (F=140.26, 147.47, 223.08, 130.46, 43.56, 183.33, 74.71, 209.94, 587.99, 221.34, all P<0.01 ). (2)Right ventricle contractile function indexes : right ventricular area change rate((40.1±1.6)%), three tricuspid ring systolic displacement((2.2±0.2) cm), tricuspid valve peak systolic flow velocity((13.8±0.9) cm/s)in group B were lower than those in group A((46.3±1.7)%, (2.5±0.3) cm, (16.7±1.2) cm/s)and control group((46.8±1.5)%, (2.6±0.3) cm, (17.2±1.4) cm/s), the difference was statistically significant(F=200.81, 21.86, 88.85, all P<0.01 ). Conclusion Children with congenital heart disease associated pulmonary hypertension have right ventricle morphological changes and right ventricular systolic function decreasing.Right ventricular morphological examination has important clinical value. Key words: Congenital heart disease associated pulmonary hypertension; Right ventricular morphology; Children
{"title":"Clinical value of right ventricular morphology in children with congenital heart disease associated pulmonary hypertension","authors":"Xue-jiao Zhang, Qiaolan Zhou, Qingqiang Qian, Yanmin Kan","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.06.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.06.008","url":null,"abstract":"Objective \u0000To investigate clinical value of right ventricular morphology in children with congenital heart disease associated pulmonary hypertension. \u0000 \u0000 \u0000Methods \u0000From October 2014 to October 2017, 37 children with congenital heart disease without associated pulmonary hypertension (resting pulmonary systolic pressure ≤ 30 mmHg, 1 mmHg=0.133 kPa) were selected as group A. Thirty-seven children with congenital heart disease and associated pulmonary hypertension (resting pulmonary systolic pressure>30 m). were in group B, and 37 healthy children were in control group.Echocardiography was performed to compare the results of right ventricular morphology and systolic function in three groups. \u0000 \u0000 \u0000Results \u0000(1)Right ventricular morphology indexes: right atrium upper and lower diameter((56.8±4.0) mm), right atrium left and right diameter((49.2±3.3) mm), right ventricle basal segment inner diameter((43.7±2.5) mm), right ventricle medial diameter((41.7±3.9) mm), right ventricle long axis distance((73.4±6.2) mm), sternum sidelines right ventricular outflow tract proximal end diameter((37.8±2.4) mm), short axis view right ventricular outflow tract distal internal diameter((33.6±2.1) mm), main pulmonary artery internal diameter((30.5±2.5)mm), right ventricle end diastolic area((31.6±1.8) cm2), right ventricle end systolic area((19.0±2.7) cm2)in group B were higher than those in group A((46.2±3.1) mm, (40.4±2.8) mm, (34.6±2.2) mm, (32.5±2.6) mm, (65.1±4.7) mm, (30.2±2.0) mm, (29.4±1.8) mm, (23.0±1.6) mm, (22.5±1.1) cm2, (11.6±1.2) cm2)and control group((45.3±2.6) mm, (39.5±1.7) mm, (34.0±1.9) mm, (31.8±2.0) mm, (63.2±3.8) mm, (29.6±1.7) mm, (28.9±1.5) mm, (22.4±1.4) mm, (22.1±1.0) cm2, (11.3±0.9) cm2), (F=140.26, 147.47, 223.08, 130.46, 43.56, 183.33, 74.71, 209.94, 587.99, 221.34, all P<0.01 ). (2)Right ventricle contractile function indexes : right ventricular area change rate((40.1±1.6)%), three tricuspid ring systolic displacement((2.2±0.2) cm), tricuspid valve peak systolic flow velocity((13.8±0.9) cm/s)in group B were lower than those in group A((46.3±1.7)%, (2.5±0.3) cm, (16.7±1.2) cm/s)and control group((46.8±1.5)%, (2.6±0.3) cm, (17.2±1.4) cm/s), the difference was statistically significant(F=200.81, 21.86, 88.85, all P<0.01 ). \u0000 \u0000 \u0000Conclusion \u0000Children with congenital heart disease associated pulmonary hypertension have right ventricle morphological changes and right ventricular systolic function decreasing.Right ventricular morphological examination has important clinical value. \u0000 \u0000 \u0000Key words: \u0000Congenital heart disease associated pulmonary hypertension; Right ventricular morphology; Children","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43493364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.06.004
Wenli Zhao, Wenli Yang
Objective To evaluate the nutritional status of children with non-Hodgkin lymphoma (NHL) during induction chemotherapy, and to understand the incidence of malnutrition, so as to give nutrition intervention in time. Methods From January 2017 to December 2018, 257 children with NHL were selected from the Center for Hematological Oncology, Peking Children′s Hospital Affiliated to Capital Medical University.Nutritional status and growth risk screening tools were used to assess the nutritional risk of the children, and the malnutrition was classified according to the height and body weight.The body mass, height and other anthropometric indexes, hemoglobin, prealbumin, albumin and other laboratory indexes were measured at the end of initial diagnosis and induction chemotherapy. Results There were 223 cases of moderate nutritional risk (86.8%) and 34 cases of high nutritional risk (13.2%). After treatment, the nutritional status of the children decreased: 13 cases of mild malnutrition, 1 case of moderate malnutrition, 4 cases of overweight and 3 cases of obesity before treatment; 32 cases of mild malnutrition, 9 cases of moderate malnutrition, 5 cases of severe malnutrition, 3 cases of overweight and 2 cases of obesity after treatment.Ninety-six patients received nutritional support (37.4%), including 15 cases of parenteral nutrition and 81 cases of enteral nutrition.The body weight ((29.50±15.13) kg before and after chemotherapy (27.60±14.30) kg) and body mass index ((17.2±3.28) kg/m2 before and (16.1±3.13) kg/m2 after chemotherapy) decreased significantly (t=12.404, 13.949, all P<0.01). Laboratory indicators except prealbumin were lower in hemoglobin ((109.00±15.78) g/L), albumin ((37.40±4.38) g/L), total lymphocyte ((1.58±1.26)×109/L) than before treatment (hemoglobin(117.90±21.06) g/L), (albumin (39.60±6.70) g/L), (total lymphocyte (2.98±2.87)×109/L)) (t=6.514, 4.834, 7.420, all P<0.01). Conclusion There is a high incidence of malnutrition in NHL children after initial treatment.Early screening of nutritional risk and optimizing nutritional treatment are one of the ways to improve the clinical efficacy of NHL children. Key words: Non-hodgkin′slymphoma; Nutritional assessment; Malnutrition; Pediatrics
{"title":"Nutritional assessment of children with non-Hodgkinundefineds lymphoma during induced chemotherapy","authors":"Wenli Zhao, Wenli Yang","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.06.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.06.004","url":null,"abstract":"Objective \u0000To evaluate the nutritional status of children with non-Hodgkin lymphoma (NHL) during induction chemotherapy, and to understand the incidence of malnutrition, so as to give nutrition intervention in time. \u0000 \u0000 \u0000Methods \u0000From January 2017 to December 2018, 257 children with NHL were selected from the Center for Hematological Oncology, Peking Children′s Hospital Affiliated to Capital Medical University.Nutritional status and growth risk screening tools were used to assess the nutritional risk of the children, and the malnutrition was classified according to the height and body weight.The body mass, height and other anthropometric indexes, hemoglobin, prealbumin, albumin and other laboratory indexes were measured at the end of initial diagnosis and induction chemotherapy. \u0000 \u0000 \u0000Results \u0000There were 223 cases of moderate nutritional risk (86.8%) and 34 cases of high nutritional risk (13.2%). After treatment, the nutritional status of the children decreased: 13 cases of mild malnutrition, 1 case of moderate malnutrition, 4 cases of overweight and 3 cases of obesity before treatment; 32 cases of mild malnutrition, 9 cases of moderate malnutrition, 5 cases of severe malnutrition, 3 cases of overweight and 2 cases of obesity after treatment.Ninety-six patients received nutritional support (37.4%), including 15 cases of parenteral nutrition and 81 cases of enteral nutrition.The body weight ((29.50±15.13) kg before and after chemotherapy (27.60±14.30) kg) and body mass index ((17.2±3.28) kg/m2 before and (16.1±3.13) kg/m2 after chemotherapy) decreased significantly (t=12.404, 13.949, all P<0.01). Laboratory indicators except prealbumin were lower in hemoglobin ((109.00±15.78) g/L), albumin ((37.40±4.38) g/L), total lymphocyte ((1.58±1.26)×109/L) than before treatment (hemoglobin(117.90±21.06) g/L), (albumin (39.60±6.70) g/L), (total lymphocyte (2.98±2.87)×109/L)) (t=6.514, 4.834, 7.420, all P<0.01). \u0000 \u0000 \u0000Conclusion \u0000There is a high incidence of malnutrition in NHL children after initial treatment.Early screening of nutritional risk and optimizing nutritional treatment are one of the ways to improve the clinical efficacy of NHL children. \u0000 \u0000 \u0000Key words: \u0000Non-hodgkin′slymphoma; Nutritional assessment; Malnutrition; Pediatrics","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48521135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.06.005
Xudong Gao, Kun Yang, Keming Zhang, H. Yao, Wen-lin Bai, Junhua Zhang
Objective To analyze the correlation between the clinical characteristics and the incidence of postoperative hepatic encephalopathy in patients with cirrhosis who received transjugular intrahepatic portosystemic shunt (TIPS). Methods The clinical data of 80 patients with liver cirrhosis hospitalized in the Fifth Medical Center of PLA General Hospital from March 2015 to March 2017 were retrospectively analyzed.The related factors of hepatic encephalopathy complications after TIPS treatment were analyzed. Results The cumulative incidence of hepatic encephalopathy was about 23.75% (19/80) in one year after TIPS operation.Through single factor analysis and multi factor Logistic regression analysis, it was found that the two factors of preoperative platelet level and the location of tips blood shunt were closely related to the occurrence of hepatic encephalopathy after TIPS operation.The ROC curve suggested that the AUC of preoperative platelet level and the location of tips blood shunt were 0.657 and 0.668, respectively.The sensitivity and specificity of the former were 70.0%, 52.6% and the cutoff value was 51×109/L, respectively, while those of the latter were 70.5% and 63.2%, respectively. Conclusion Preoperative platelets level>51×109/L or shunting of the left branches of the portal vein may indicate a lower incidence of hepatic encephalopathy. Key words: Transjugular intrahepatic portosystemic shunt; Hepatic encephalopathy; Liver cirrhosis
{"title":"Multivariate analysis of the incidence of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt","authors":"Xudong Gao, Kun Yang, Keming Zhang, H. Yao, Wen-lin Bai, Junhua Zhang","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.06.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.06.005","url":null,"abstract":"Objective \u0000To analyze the correlation between the clinical characteristics and the incidence of postoperative hepatic encephalopathy in patients with cirrhosis who received transjugular intrahepatic portosystemic shunt (TIPS). \u0000 \u0000 \u0000Methods \u0000The clinical data of 80 patients with liver cirrhosis hospitalized in the Fifth Medical Center of PLA General Hospital from March 2015 to March 2017 were retrospectively analyzed.The related factors of hepatic encephalopathy complications after TIPS treatment were analyzed. \u0000 \u0000 \u0000Results \u0000The cumulative incidence of hepatic encephalopathy was about 23.75% (19/80) in one year after TIPS operation.Through single factor analysis and multi factor Logistic regression analysis, it was found that the two factors of preoperative platelet level and the location of tips blood shunt were closely related to the occurrence of hepatic encephalopathy after TIPS operation.The ROC curve suggested that the AUC of preoperative platelet level and the location of tips blood shunt were 0.657 and 0.668, respectively.The sensitivity and specificity of the former were 70.0%, 52.6% and the cutoff value was 51×109/L, respectively, while those of the latter were 70.5% and 63.2%, respectively. \u0000 \u0000 \u0000Conclusion \u0000Preoperative platelets level>51×109/L or shunting of the left branches of the portal vein may indicate a lower incidence of hepatic encephalopathy. \u0000 \u0000 \u0000Key words: \u0000Transjugular intrahepatic portosystemic shunt; Hepatic encephalopathy; Liver cirrhosis","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47155823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.06.019
Qi Zhang, Biao Xu, Lin Zhu, Qing-hua Zhang
Objective To compare the clinical features of diffuse capillary endothelial proliferative Henoch-Schonlein purpura nephritis (DEP-HSPN) with or without crescent formation. Methods The clinical data of 110 children with DEP-HSPN admitted to Dalian Central Hospital and the First Affiliated Hospital of Dalian Medical University from January 2008 to January 2018 were analyzed retrospectively.Among them, 24 cases were divided into non crescentic group and 86 cases into crescentic group.The clinical characteristics and prognosis of the two groups were statistically analyzed. Results The clinical manifestations of children without crescent body formation group were all type III.There were 35 cases of type III and 51 cases of type V in the crescent body formation group.Compared with non-crescent formation group, the proportion of gross hematuria(83.7%(72/86) vs.29.2%(7/24), χ2=10.396), urine red blood cell count ((112.4±20.3)/HP vs.(45.2±10.6)/HP, t=9.697), 24 h urine protein ((2471.6±242.0) mg/d vs.(1358.5±109.3) mg/d, t=6.372) and serum creatinine ((44.9±9.6) μmol/L vs.(32.3±5.2) μmol/L, t=5.390) increased significantly, the serum albumin ((22.8±3.8) g/L vs.(35.1±5.7) g/L, t=4.806)decreased significantly (all P 0.05). Conclusion When DEP-HSPN is accompanied by crescent formation, gross hematuria, urinary erythrocyte count and the proportion of massive proteinuria increase significantly.Combined immunosuppressive therapy in acute stage and long-term sequential treatment in remission stage can achieve good prognosis. Key words: Glomerulo nephritis; Henoch-Schonlein purpura; Endocapillary proliferation; Children
{"title":"Comparison of clinical characteristics of diffused capillary endothelial proliferative Henoch-Schonlein purpura nephritis children with or without crescents formation","authors":"Qi Zhang, Biao Xu, Lin Zhu, Qing-hua Zhang","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.06.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.06.019","url":null,"abstract":"Objective \u0000To compare the clinical features of diffuse capillary endothelial proliferative Henoch-Schonlein purpura nephritis (DEP-HSPN) with or without crescent formation. \u0000 \u0000 \u0000Methods \u0000The clinical data of 110 children with DEP-HSPN admitted to Dalian Central Hospital and the First Affiliated Hospital of Dalian Medical University from January 2008 to January 2018 were analyzed retrospectively.Among them, 24 cases were divided into non crescentic group and 86 cases into crescentic group.The clinical characteristics and prognosis of the two groups were statistically analyzed. \u0000 \u0000 \u0000Results \u0000The clinical manifestations of children without crescent body formation group were all type III.There were 35 cases of type III and 51 cases of type V in the crescent body formation group.Compared with non-crescent formation group, the proportion of gross hematuria(83.7%(72/86) vs.29.2%(7/24), χ2=10.396), urine red blood cell count ((112.4±20.3)/HP vs.(45.2±10.6)/HP, t=9.697), 24 h urine protein ((2471.6±242.0) mg/d vs.(1358.5±109.3) mg/d, t=6.372) and serum creatinine ((44.9±9.6) μmol/L vs.(32.3±5.2) μmol/L, t=5.390) increased significantly, the serum albumin ((22.8±3.8) g/L vs.(35.1±5.7) g/L, t=4.806)decreased significantly (all P 0.05). \u0000 \u0000 \u0000Conclusion \u0000When DEP-HSPN is accompanied by crescent formation, gross hematuria, urinary erythrocyte count and the proportion of massive proteinuria increase significantly.Combined immunosuppressive therapy in acute stage and long-term sequential treatment in remission stage can achieve good prognosis. \u0000 \u0000 \u0000Key words: \u0000Glomerulo nephritis; Henoch-Schonlein purpura; Endocapillary proliferation; Children","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42025486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.06.011
Xiaoqian Chen, Huiqing Ye, Zhuang-gui Chen, H. Zhong, Chan-qing Luo, Liyi He, Mingwei Liu
Objective To investigate and analyze the similarities of allergens in children of the same family with susceptibility to the same genetic background and environmental factors. Methods From January 2013 to December 2017, a total of 142 pairs of children with allergic diseases aged 0-15 years and their siblings (284 cases) were collected from the outpatient or hospitalized treatment of Pediatrics and otolaryngology department of the First People′s Hospital of Foshan City, the Third Affiliated Hospital of Sun Yat-sen University.The elder group was brother or sister (142 cases), and the younger group was brother or sister (142 cases). The serum allergen sIgE was tested by Allergy Screen allergen detection system (developed by Germany MEDIWISS Company) and the similarity of allergens was analyzed. Results A total of 142 siblings (284 cases) had systemic symptoms of allergic diseases in varying degrees, including respiratory symptoms (cough (47 cases in the old group, 32 cases in the young group), χ2=3.946, P=0.047), nasal obstruction (41 cases in the old group, 19 cases in the young group, χ2=10.227, P=0.001), runny nose (46 cases in the old group, 26 cases in the young group, χ2=7.442, P=0.006), gastrointestinal symptoms (abdominal pain (11cases in the old group, 7 cases in the young group, χ2=4.63, P=0.031), skin symptoms(urticaria (18 cases in the old group, 8 cases in the young group, χ2=4.234, P=0.037)) and so on, the difference was statistically significant.Some children have multiple organ system symptoms at the same time.There was no significant difference between the old group and the young group in the early use of antibiotics, mode of production and feeding mode within 6 months (all P>0.05). Among the two groups, house dust mite and cockroach (r=0.831, P<0.05), dog hair and house dust (r=0.717, P<0.05), cypress, elm, willow, birch, oak, maple, walnut, sycamore, poplar and Dianqing, branching, yanqu, and heiqu (r=0.683, P<0.05). Conclusion With the same genetic background and the same environmental factors, the allergens in siblings are similar. Key words: Siblings; Allergen; Similarity
{"title":"Distribution and similarity of allergens in children in the same family","authors":"Xiaoqian Chen, Huiqing Ye, Zhuang-gui Chen, H. Zhong, Chan-qing Luo, Liyi He, Mingwei Liu","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.06.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.06.011","url":null,"abstract":"Objective \u0000To investigate and analyze the similarities of allergens in children of the same family with susceptibility to the same genetic background and environmental factors. \u0000 \u0000 \u0000Methods \u0000From January 2013 to December 2017, a total of 142 pairs of children with allergic diseases aged 0-15 years and their siblings (284 cases) were collected from the outpatient or hospitalized treatment of Pediatrics and otolaryngology department of the First People′s Hospital of Foshan City, the Third Affiliated Hospital of Sun Yat-sen University.The elder group was brother or sister (142 cases), and the younger group was brother or sister (142 cases). The serum allergen sIgE was tested by Allergy Screen allergen detection system (developed by Germany MEDIWISS Company) and the similarity of allergens was analyzed. \u0000 \u0000 \u0000Results \u0000A total of 142 siblings (284 cases) had systemic symptoms of allergic diseases in varying degrees, including respiratory symptoms (cough (47 cases in the old group, 32 cases in the young group), χ2=3.946, P=0.047), nasal obstruction (41 cases in the old group, 19 cases in the young group, χ2=10.227, P=0.001), runny nose (46 cases in the old group, 26 cases in the young group, χ2=7.442, P=0.006), gastrointestinal symptoms (abdominal pain (11cases in the old group, 7 cases in the young group, χ2=4.63, P=0.031), skin symptoms(urticaria (18 cases in the old group, 8 cases in the young group, χ2=4.234, P=0.037)) and so on, the difference was statistically significant.Some children have multiple organ system symptoms at the same time.There was no significant difference between the old group and the young group in the early use of antibiotics, mode of production and feeding mode within 6 months (all P>0.05). Among the two groups, house dust mite and cockroach (r=0.831, P<0.05), dog hair and house dust (r=0.717, P<0.05), cypress, elm, willow, birch, oak, maple, walnut, sycamore, poplar and Dianqing, branching, yanqu, and heiqu (r=0.683, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000With the same genetic background and the same environmental factors, the allergens in siblings are similar. \u0000 \u0000 \u0000Key words: \u0000Siblings; Allergen; Similarity","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41422960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：