Clinical Oral Implants Research最新文献_第5页

Long-Term Performance of Bi-Layered Single Crowns Supported by Zirconia Implants: 7.5-Year Results of a Two-Center Prospective Cohort Study 氧化锆种植体支持双层单冠的长期性能：一项为期7.5年的双中心前瞻性队列研究结果。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-26 DOI: 10.1111/clr.70051

Marc Balmer, Benedikt C. Spies, Margherita G. Liguori, Kirstin Vach, Ronald E. Jung, Ralf-Joachim Kohal

Objective

To evaluate the survival and success rates of veneered zirconia-based single crowns (SCs) supported by zirconia implants in posterior regions, along with patient-reported outcomes, over 7.5 years.

Materials and Methods

Forty-five patients received zirconia implant-supported posterior SCs (n = 45) composed of zirconia frameworks layered with a leucite-reinforced feldspathic ceramic. At 7.5 years, clinical parameters and technical complications were assessed. Technical success was determined according to modified United States Public Health Service (USPHS) criteria. Patient-reported outcome measures (PROs) were evaluated using visual analog scales (VAS). Wilcoxon matched-pairs signed-rank test, mixed-effects ordered logistic regression, and linear mixed models analyzed time-dependent effects.

Results

Thirty SCs (n = 30) could be evaluated at the 7.5-year follow-up (mean: 92.1 ± 3.4 months). Kaplan–Meier survival for SCs was 97.5% [95% CI: 83.6%–99.6%]. Success dropped to 79.4% [63.0%–89.2%] due to reconstructions with major chipping (n = 3), occlusal roughness (n = 7), marginal crevice (n = 1), and over-contouring (n = 2). PROs showed significant improvements from pre-treatment to delivery (VAS scores: 93%–97%) and remained stable throughout the follow-up period.

Conclusion

Veneered zirconia-based SCs supported by zirconia implants in posterior sites demonstrated high survival rates and consistently met patients' functional and esthetic expectations. Despite these favorable outcomes, the considerable incidence of technical complications warrants further investigation through long-term clinical studies.

Clinical Significance

While veneered zirconia crowns offer favorable esthetics, their susceptibility to chipping in posterior regions suggests that monolithic alternatives may be preferable. Further research is needed to optimize material selection and minimize technical complications.

目的评估后牙区氧化锆种植体支持的氧化锆单冠（SCs）在7.5年以上的生存率和成功率，以及患者报告的结果。材料与方法45例患者接受了由氧化锆框架与白晶石增强长石陶瓷层合而成的氧化锆支撑的后路sc （n = 45）。7.5岁时，评估临床参数和技术并发症。技术成功与否是根据修改后的美国公共卫生局（USPHS）标准确定的。采用视觉模拟量表（VAS）评估患者报告的预后指标（PROs）。Wilcoxon配对对符号秩检验、混合效应有序逻辑回归和线性混合模型分析了随时间变化的效应。结果随访7.5年（平均：92.1±3.4个月），共获得30例SCs。SCs的Kaplan-Meier存活率为97.5% [95% CI: 83.6%-99.6%]。由于主要切屑（n = 3）、咬合粗糙（n = 7）、边缘缝隙（n = 1）和过度轮廓（n = 2）的重建，成功率下降到79.4%[63.0%-89.2%]。从治疗前到分娩，PROs表现出显著的改善（VAS评分：93%-97%），并在整个随访期间保持稳定。结论氧化锆种植体支持的氧化锆贴面干细胞具有较高的存活率，并始终满足患者的功能和美学期望。尽管这些良好的结果，相当大的技术并发症的发生率值得通过长期的临床研究进一步调查。临床意义虽然贴面氧化锆冠具有良好的美观性，但其后牙区易碎裂，提示整体替代可能更可取。需要进一步的研究来优化材料选择和减少技术复杂性。

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引用次数: 0

Zirconia Minimizes Myeloid Innate Immunity as Dental Implants: An In Silico and In Vivo Study 氧化锆作为牙种植体最大限度地减少髓系先天免疫：一项在硅和体内的研究。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-25 DOI: 10.1111/clr.70037

Li-Tzu Wang, Hsuan-Hao Chang, Yi-Ting Liao, Wei-An Chen, Yu-Wen Huang, Yi-Wen Chen

Aim

While titanium has traditionally been the industry standard, zirconia presents superior physical and chemical properties that merit further investigation into its clinical efficacy. This study aims to examine the immunological responses associated with zirconia and titanium dental implants, emphasizing the potential advantages of zirconia as a viable alternative.

Materials and Methods

This study compares the immune responses to titanium and zirconia implants using a murine model, in which two implants were placed in the maxillary edentulous region for 7 days. Following this period, peri-implant tissue was harvested from 9 and 45 mice to assess myeloid immunity at both the transcriptomic and cellular levels, respectively.

Results

Our findings indicate that zirconia implants exhibit superior biocompatibility compared to titanium implants, evidenced by transcriptomic data showing a minimal myeloid cell-mediated inflammatory response. Specifically, zirconia implants significantly reduce the infiltration and attachment of myeloid cells, particularly polymorphonuclear neutrophils. Additionally, zirconia implants prevent the polarization of macrophages to the inflammatory M1 phenotype, which is markedly heightened in titanium peri-implant tissues, promoting instead a shift toward the regenerative M2 phenotype.

Conclusions

These results suggest that zirconia implants can minimize inflammation and promote better healing. This experimental in vivo study provides evidence that zirconia implants offer a more biocompatible solution in the field of dental restoration compared to titanium.

虽然钛传统上是行业标准，但氧化锆具有优越的物理和化学性能，值得进一步研究其临床疗效。本研究旨在研究氧化锆和钛种植体的免疫反应，强调氧化锆作为一种可行的替代方案的潜在优势。材料与方法本研究采用小鼠模型，在上颌无牙区放置两种钛和氧化锆种植体7天，比较两种种植体的免疫反应。在这段时间之后，分别从9只和45只小鼠身上采集种植体周围组织，在转录组学和细胞水平上评估骨髓免疫。结果我们的研究结果表明，与钛种植体相比，氧化锆种植体具有更好的生物相容性，转录组学数据显示骨髓细胞介导的炎症反应最小。具体来说，氧化锆植入物显著减少骨髓细胞的浸润和附着，特别是多形核中性粒细胞。此外，氧化锆植入物阻止巨噬细胞向炎性M1表型的极化，这在钛种植体周围组织中显著增强，从而促进巨噬细胞向再生M2表型的转变。结论氧化锆种植体可以减少炎症，促进愈合。本实验体内研究证明，与钛相比，氧化锆种植体在牙齿修复领域提供了更好的生物相容性解决方案。

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引用次数: 0

Cross-Linked Volume-Stable Collagen Matrix Versus Connective Tissue Graft for Soft Tissue Augmentation at Implant Site. A Non-Inferiority, Multicenter Randomized Clinical Trial 交联体积稳定的胶原基质与结缔组织移植物在种植体部位的软组织增强。一项非劣效性、多中心随机临床试验

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-22 DOI: 10.1111/clr.70050

Francesco Cairo, Cosimo Rupe, Raffaele Cavalcanti, Luca Landi, Antonio Rupe, Nicola Marco Sforza, Walter Castelluzzo, Maria Di Martino, Luigi Barbato

Aims

To compare the efficacy of cross-linked volume-stable collagen matrix (VCMX) versus connective tissue graft (CTG) to increase buccal peri-implant mucosal thickness (MT) around dental implants.

Methods

The present is a parallel, randomized multi-center clinical trial, according to the CONSORT statement. Clinical centers were four Italian periodontal settings. All patients received a soft tissue augmentation procedure, by means of CTG or VCMX. The primary outcome variable was peri-implant mucosal thickness (MT) difference at 12 months follow-up. The statistical unit was the patient. An analysis of covariance was performed for this outcome variable. Secondary outcomes were patient-reported outcome measures (PROMs), complications, variability among operators, and changes in keratinized mucosa width (KMW).

Results

A total of 98 patients completed the study, 49 in each group. MT increase was 1.0 ± 0.75 in the CTG group and 0.66 ± 0.58 mm in the VCMX group. CTG showed superior results to VCMX for MT gain (0.37 mm, 95% CI: 0.13–0.61, p = 0.002). In cases of Baseline MT ≥ 2 mm, CTG and VCMX yielded comparable results. VCMX was associated with shorter chair time (diff: 10.0 min; 95% CI: 5.02 to 14.98; p < 0.0001). Patients in the VCMX group experienced fewer days of discomfort (0.46 days, 95% CI: 0.06–0.99, p = 0.05), while no differences were found for final aesthetic and general satisfaction (CTG: 99.28 ± 2.28, VCMX: 98.48 ± 3.92, p = 0.22).

Conclusions

Both techniques improved MT, and CTG yielded better outcomes. VCMX was associated with shorter chair time and less postoperative discomfort, but both procedures achieved excellent final patient satisfaction.

目的比较交联体积稳定型胶原基质（VCMX）与结缔组织移植物（CTG）在增加种植体周围口腔黏膜厚度（MT）方面的效果。方法：根据CONSORT声明，本研究是一项平行、随机的多中心临床试验。临床中心是四个意大利牙周设置。所有患者均通过CTG或VCMX接受软组织增强手术。主要结局变量为12个月随访时种植体周围粘膜厚度（MT）差异。统计单位是病人。对该结果变量进行协方差分析。次要结果是患者报告的结果测量值（PROMs）、并发症、操作人员之间的差异和角化粘膜宽度（KMW）的变化。结果共98例患者完成研究，每组49例。CTG组MT增加1.0±0.75 mm， VCMX组MT增加0.66±0.58 mm。CTG在MT增益方面优于VCMX （0.37 mm, 95% CI: 0.13-0.61, p = 0.002）。在基线MT≥2mm的情况下，CTG和VCMX的结果相当。VCMX与较短的坐椅时间相关（差异：10.0 min; 95% CI: 5.02至14.98;p < 0.0001）。VCMX组患者的不适天数较少（0.46天，95% CI: 0.06-0.99, p = 0.05），而最终美学和总体满意度无差异（CTG: 99.28±2.28,VCMX: 98.48±3.92,p = 0.22）。结论两种技术均能改善MT， CTG治疗效果更好。VCMX与更短的坐椅时间和更少的术后不适相关，但两种手术都获得了极好的最终患者满意度。

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引用次数: 0

Does Calcium Phosphate Peri-Implant Grafting Improve Osseointegration of Dental Implants? An Experimental In Vivo Study 磷酸钙种植体周围移植能改善种植体的骨整合吗？一项实验性体内研究。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-16 DOI: 10.1111/clr.70046

F. C. A. Lima, S. De Moraes, S. C. Sartoretto, P. S. Nunes, C. M. S. F. dos Santos, B. Ghiraldini, F. J. B. Bezerra, J. M. Granjeiro, M. D. Calasans-Maia, R. S. Louro

Objective

This in vivo study aimed to evaluate the osseointegration of dental implants with a nanostructured hydroxyapatite (HAnano) coating or a double acid-etched (DAA) surface, grafted with or without calcium phosphate in the peri-implant gap, in low-density bone in a sheep model.

Materials and Methods

Thirty implants (15 HAnano and 15 DAA) were installed in the iliac crest of five sheep (2–4 years old). Six implants were placed per animal: two with a xenograft biomaterial, two with an alloplastic biomaterial, and two without grafting (control). Microtomographic analyses evaluated the percentage of bone and biomaterial for all groups. Histomorphometric analysis assessed bone-implant contact (BIC), bone occupied area fraction (BAFo), and biomaterial presence after an 8-week healing period. Data were analyzed using repeated-measures ANOVA or mixed-effects models with a significance level of 0.05.

Results

No complications were observed during the healing period. The average BIC across all groups was 55%, ranging from 4.6% to 67.7%. BAFo averaged 30%, with biomaterial occupying 22% and connective tissue 44% of the interface area. There were no statistically significant differences between grafted and non-grafted groups for BIC (p = 0.413), BAFo (p = 0.097), connective tissue presence (p = 0.192), and for the percentage of bone and biomaterial (p = 0.959), bone percentage (p = 0.283), or biomaterial percentage (p > 0.0959).

Conclusion

Peri-implant grafting with xenograft or alloplastic biomaterials did not significantly enhance osseointegration compared to ungrafted implants in small peri-implant defects. These results suggest that spontaneous healing may suffice in such cases.

目的：本体内研究旨在评估纳米结构羟基磷灰石（HAnano）涂层或双酸蚀（DAA）表面的牙种植体在低密度骨羊模型中的骨整合，在种植体周围间隙中植入或不植入磷酸钙。材料与方法将30个假体（HAnano 15个，DAA 15个）植入5只2-4岁绵羊的髂骨。每只动物放置6个植入物：2个采用异种移植生物材料，2个采用同种异体生物材料，2个不采用移植（对照组）。显微层析分析评估了所有组的骨和生物材料的百分比。组织形态计量学分析评估骨-种植体接触（BIC）、骨占据面积分数（BAFo）和8周愈合期后生物材料的存在。数据分析采用重复测量方差分析或混合效应模型，显著性水平为0.05。结果愈合期间无并发症发生。所有小组的平均BIC为55%，范围从4.6%到67.7%不等。BAFo平均占30%，生物材料占22%，结缔组织占44%。移植物组与非移植物组在BIC （p = 0.413）、BAFo （p = 0.097）、结缔组织存在（p = 0.192）以及骨和生物材料百分比（p = 0.959）、骨百分比（p = 0.283）或生物材料百分比（p > 0.0959）方面差异均无统计学意义。结论同种异体或同种异体生物材料在种植体周围小缺损中的骨整合效果不明显。这些结果表明，在这种情况下，自发愈合可能就足够了。

{"title":"Does Calcium Phosphate Peri-Implant Grafting Improve Osseointegration of Dental Implants? An Experimental In Vivo Study","authors":"F. C. A. Lima, S. De Moraes, S. C. Sartoretto, P. S. Nunes, C. M. S. F. dos Santos, B. Ghiraldini, F. J. B. Bezerra, J. M. Granjeiro, M. D. Calasans-Maia, R. S. Louro","doi":"10.1111/clr.70046","DOIUrl":"10.1111/clr.70046","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This in vivo study aimed to evaluate the osseointegration of dental implants with a nanostructured hydroxyapatite (HAnano) coating or a double acid-etched (DAA) surface, grafted with or without calcium phosphate in the peri-implant gap, in low-density bone in a sheep model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Thirty implants (15 HAnano and 15 DAA) were installed in the iliac crest of five sheep (2–4 years old). Six implants were placed per animal: two with a xenograft biomaterial, two with an alloplastic biomaterial, and two without grafting (control). Microtomographic analyses evaluated the percentage of bone and biomaterial for all groups. Histomorphometric analysis assessed bone-implant contact (BIC), bone occupied area fraction (BAFo), and biomaterial presence after an 8-week healing period. Data were analyzed using repeated-measures ANOVA or mixed-effects models with a significance level of 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No complications were observed during the healing period. The average BIC across all groups was 55%, ranging from 4.6% to 67.7%. BAFo averaged 30%, with biomaterial occupying 22% and connective tissue 44% of the interface area. There were no statistically significant differences between grafted and non-grafted groups for BIC (<i>p</i> = 0.413), BAFo (<i>p</i> = 0.097), connective tissue presence (<i>p</i> = 0.192), and for the percentage of bone and biomaterial (<i>p</i> = 0.959), bone percentage (<i>p</i> = 0.283), or biomaterial percentage (<i>p</i> > 0.0959).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Peri-implant grafting with xenograft or alloplastic biomaterials did not significantly enhance osseointegration compared to ungrafted implants in small peri-implant defects. These results suggest that spontaneous healing may suffice in such cases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 1","pages":"18-32"},"PeriodicalIF":5.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Communication 第32届欧洲骨整合协会年度科学会议2025年9月18日至20日。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-15 DOI: 10.1111/clr.70008

引用次数: 0

ePoster 第32届欧洲骨整合协会年度科学会议2025年9月18日至20日。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-15 DOI: 10.1111/clr.70007

引用次数: 0

Dual Growth Factor Release From Collagen Based Multilayer Films on Ti-Surfaces Enhances Periimplant Bone Formation and Angiogenic Activity—An Experimental In-Vivo Study ti表面基于胶原的多层膜释放双重生长因子促进种植周骨形成和血管生成活性——一项体内实验研究

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-12 DOI: 10.1111/clr.70045

Philipp Kauffmann, Susanne Wolfer, Christina Behrens, Pauline Schlosser, Christian Dullin, Uwe Schirmer, Klaus Liefeith, Henning Schliephake

Objectives

The aim of the present study was to assess the effect of dual growth factor release from collagen-based polyelectrolyte multilayer films (PEMs) on titanium implants on periimplant bone formation and angiogenetic activity in minipig mandibles.

Material and Methods

Disc shaped Ti implants (5 × 7 × 1 mm) were coated with polyelectrolyte multilayer films and loaded with rhBMP-2, rhVEGF165, and a combination of both. Uncoated and unloaded Ti implants served as controls. The implants were inserted press-fit into 5 mm trephine cavities in minipig mandibles and evaluated after 4 and 13 weeks for bone formation, bone implant contact, and periimplant expression of CD31.

Results

After 4 weeks, there was no significant difference in periimplant bone formation nor bone-implant contact between the different surface conditions. CD31 expression was significantly increased around PEM coated implants loaded with VEGF and BMP each. After 13 weeks, bone implant contact and bone formation were significantly increased only around PEM coated implants with simultaneous release of BMP-2 and VEGF165. Expression of CD31 was significantly enhanced around all PEM coated implants loaded with growth factors regardless of the type or combination.

Conclusion

It is concluded that simultaneous release of rhBMP-2 and rhVEGF165 may be required to achieve significant improvement of periimplant bone formation and bone implant contact. Angiogenesis as reflected by CD31 expression is enhanced by both rhVEGF165 and rhBMP-2 to a similar extent without an additive effect of simultaneous release.

目的研究胶原基聚电解质多层膜（PEMs）释放双生长因子对微型猪下颌骨种植体周围骨形成和血管生成活性的影响。材料与方法采用聚电解质多层膜包覆片状钛植入物（5 × 7 × 1 mm），并负载rhBMP-2、rhVEGF165或两者的组合。未涂覆和卸载的钛植入物作为对照。将种植体压贴合置入小型猪下颌骨5 mm的环形腔中，在4周和13周后评估骨形成、骨种植体接触和种植体周围CD31的表达。结果4周后，不同表面条件下种植体周围骨形成及骨与种植体接触无显著差异。CD31的表达在分别装载VEGF和BMP的PEM包被植入物周围显著增加。13周后，骨种植体接触和骨形成仅在PEM涂层种植体周围显著增加，同时释放BMP-2和VEGF165。CD31的表达在所有负载生长因子的PEM包被植入物周围显著增强，无论其类型或组合如何。结论需同时释放rhBMP-2和rhVEGF165才能显著改善种植周骨形成和种植体骨接触。通过CD31表达反映的血管生成，rhVEGF165和rhBMP-2均有相似程度的增强，但没有同时释放的叠加效应。

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引用次数: 0

Vertical Ridge Augmentation in the Anterior Maxilla Using a Dual-Texture e-PTFE Membrane and Autogenous Bone: A 2- to 5-Year Retrospective Case-Series Study 使用双纹理e - PTFE膜和自体骨在前上颌垂直嵴增强：一项2 - 5年回顾性病例系列研究

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-11 DOI: 10.1111/clr.70044

David González, Herman Sahlin, Christer Dahlin

Objectives

To evaluate a novel protocol for vertical ridge augmentation with titanium-(Ti)-reinforced dual-texture expanded polytetrafluoroethylene (e-PTFE) membranes, 100% autogenous bone, and 12 months of bone healing in the anterior maxilla.

Material and Methods

This retrospective study included 14 consecutive patients treated between 2016 and 2021. Large defects, including both vertical and horizontal components, were treated with autogenous bone grafting and non-resorbable Ti-reinforced dual-texture e-PTFE membranes. Implants were placed in the augmented bone after 12 months. All clinical and radiographical parameters were retrieved from patient records.

Results

The case series included 14 patients treated with 15 e-PTFE membranes. The mean initial vertical defect size was 7.5 ± 5.1 mm (range: 3–23 mm). All membranes remained unexposed during the entire healing period (12.6 ± 1.2 months). No complications that needed intervention occurred. Complete bone fill was achieved, that is, regenerated bone filled the entire volume created by the membrane, in all treated defects. Twenty-three implants were placed. The survival rate was 100% and the mean marginal bone level was 0.08 ± 0.11 mm after up to 5 years.

Conclusions

Excellent vertical augmentation outcomes can be achieved in the anterior maxilla using a non-resorbable Ti-reinforced e-PTFE membrane and an autogenous bone graft, followed by 12 months of healing before implant placement. The implants demonstrated stable marginal bone levels after loading. This case series has limitations, mainly the retrospective nature and small sample size, but it indicates that the proper choice of methods, materials, and healing times during GBR results in a predictable clinical outcome.

目的：评价一种采用钛（Ti）增强双纹理膨胀聚四氟乙烯（e - PTFE）膜、100%自体骨和上颌前牙12个月骨愈合的垂直嵴增强新方案。材料和方法本回顾性研究纳入了2016年至2021年间连续治疗的14例患者。大的缺陷，包括垂直和水平的组件，用自体植骨和不可吸收的钛增强双纹理e - PTFE膜进行治疗。12个月后将植入物放置在增强骨中。从患者记录中检索所有临床和影像学参数。结果14例患者接受了15个e - PTFE膜治疗。平均初始垂直缺陷尺寸为7.5±5.1 mm（范围：3-23 mm）。所有膜在整个愈合期间（12.6±1.2个月）均未暴露。未发生需要干预的并发症。在所有处理过的缺损中，实现了完全的骨填充，即再生骨填充了由膜产生的整个体积。共植入了23个植入物。术后5年生存率为100%，平均骨缘水平为0.08±0.11 mm。结论采用不可吸收性钛增强膜和自体骨移植可获得良好的上颌骨垂直增强效果，种植体植入术前愈合12个月。植入物在加载后表现出稳定的边缘骨水平。该病例系列具有局限性，主要是回顾性和小样本量，但它表明，在GBR中正确选择方法、材料和愈合时间可导致可预测的临床结果。

{"title":"Vertical Ridge Augmentation in the Anterior Maxilla Using a Dual-Texture e-PTFE Membrane and Autogenous Bone: A 2- to 5-Year Retrospective Case-Series Study","authors":"David González, Herman Sahlin, Christer Dahlin","doi":"10.1111/clr.70044","DOIUrl":"10.1111/clr.70044","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate a novel protocol for vertical ridge augmentation with titanium-(Ti)-reinforced dual-texture expanded polytetrafluoroethylene (e-PTFE) membranes, 100% autogenous bone, and 12 months of bone healing in the anterior maxilla.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This retrospective study included 14 consecutive patients treated between 2016 and 2021. Large defects, including both vertical and horizontal components, were treated with autogenous bone grafting and non-resorbable Ti-reinforced dual-texture e-PTFE membranes. Implants were placed in the augmented bone after 12 months. All clinical and radiographical parameters were retrieved from patient records.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The case series included 14 patients treated with 15 e-PTFE membranes. The mean initial vertical defect size was 7.5 ± 5.1 mm (range: 3–23 mm). All membranes remained unexposed during the entire healing period (12.6 ± 1.2 months). No complications that needed intervention occurred. Complete bone fill was achieved, that is, regenerated bone filled the entire volume created by the membrane, in all treated defects. Twenty-three implants were placed. The survival rate was 100% and the mean marginal bone level was 0.08 ± 0.11 mm after up to 5 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Excellent vertical augmentation outcomes can be achieved in the anterior maxilla using a non-resorbable Ti-reinforced e-PTFE membrane and an autogenous bone graft, followed by 12 months of healing before implant placement. The implants demonstrated stable marginal bone levels after loading. This case series has limitations, mainly the retrospective nature and small sample size, but it indicates that the proper choice of methods, materials, and healing times during GBR results in a predictable clinical outcome.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 12","pages":"1664-1674"},"PeriodicalIF":5.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Additional Cover 额外的封面

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-10 DOI: 10.1111/clr.70043

The cover 3 image is based on the article Bi-Layered Biphasic Calcium Phosphate Bone Substitute to Improve Bone Formation in Lateral Jaw Defects Applying the Principle of Guided Bone Regeneration (GBR)â€”A Pre-Clinical Randomized Controlled Study by Kiri N. Lang et al., https://doi.org/10.1111/clr.14460.

封面3的图片是基于Kiri N. Lang等人的文章《应用引导骨再生（GBR）原理改善侧颌缺损骨形成的双层双相钙磷酸盐骨替代物——临床前随机对照研究https://doi.org/10.1111/clr.14460》。

引用次数: 0

Additional Cover 额外的封面

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-10 DOI: 10.1111/clr.70042

The cover 2 image is based on the article Ridge Preservation in Extraction Sockets of Periodontally Compromised Molars With and Without Primary Wound Closure: Histological and 1-Year Implant Outcomes of a Clinical Trial by Yiping Wei et al., https://doi.org/10.1111/clr.14459.

封面2的图片是基于魏一平等人的文章《牙周受损磨牙牙槽的牙嵴保存：组织学和1年种植体临床试验结果》（https://doi.org/10.1111/clr.14459）。

引用次数: 0