Clinical Oral Implants Research最新文献

英文中文

Zirconia Minimizes Myeloid Innate Immunity as Dental Implants: An In Silico and In Vivo Study 氧化锆作为牙种植体最大限度地减少髓系先天免疫：一项在硅和体内的研究。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-25 DOI: 10.1111/clr.70037

Li-Tzu Wang, Hsuan-Hao Chang, Yi-Ting Liao, Wei-An Chen, Yu-Wen Huang, Yi-Wen Chen

Aim

While titanium has traditionally been the industry standard, zirconia presents superior physical and chemical properties that merit further investigation into its clinical efficacy. This study aims to examine the immunological responses associated with zirconia and titanium dental implants, emphasizing the potential advantages of zirconia as a viable alternative.

Materials and Methods

This study compares the immune responses to titanium and zirconia implants using a murine model, in which two implants were placed in the maxillary edentulous region for 7 days. Following this period, peri-implant tissue was harvested from 9 and 45 mice to assess myeloid immunity at both the transcriptomic and cellular levels, respectively.

Results

Our findings indicate that zirconia implants exhibit superior biocompatibility compared to titanium implants, evidenced by transcriptomic data showing a minimal myeloid cell-mediated inflammatory response. Specifically, zirconia implants significantly reduce the infiltration and attachment of myeloid cells, particularly polymorphonuclear neutrophils. Additionally, zirconia implants prevent the polarization of macrophages to the inflammatory M1 phenotype, which is markedly heightened in titanium peri-implant tissues, promoting instead a shift toward the regenerative M2 phenotype.

Conclusions

These results suggest that zirconia implants can minimize inflammation and promote better healing. This experimental in vivo study provides evidence that zirconia implants offer a more biocompatible solution in the field of dental restoration compared to titanium.

虽然钛传统上是行业标准，但氧化锆具有优越的物理和化学性能，值得进一步研究其临床疗效。本研究旨在研究氧化锆和钛种植体的免疫反应，强调氧化锆作为一种可行的替代方案的潜在优势。材料与方法本研究采用小鼠模型，在上颌无牙区放置两种钛和氧化锆种植体7天，比较两种种植体的免疫反应。在这段时间之后，分别从9只和45只小鼠身上采集种植体周围组织，在转录组学和细胞水平上评估骨髓免疫。结果我们的研究结果表明，与钛种植体相比，氧化锆种植体具有更好的生物相容性，转录组学数据显示骨髓细胞介导的炎症反应最小。具体来说，氧化锆植入物显著减少骨髓细胞的浸润和附着，特别是多形核中性粒细胞。此外，氧化锆植入物阻止巨噬细胞向炎性M1表型的极化，这在钛种植体周围组织中显著增强，从而促进巨噬细胞向再生M2表型的转变。结论氧化锆种植体可以减少炎症，促进愈合。本实验体内研究证明，与钛相比，氧化锆种植体在牙齿修复领域提供了更好的生物相容性解决方案。

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引用次数: 0

Cross-Linked Volume-Stable Collagen Matrix Versus Connective Tissue Graft for Soft Tissue Augmentation at Implant Site. A Non-Inferiority, Multicenter Randomized Clinical Trial 交联体积稳定的胶原基质与结缔组织移植物在种植体部位的软组织增强。一项非劣效性、多中心随机临床试验

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-22 DOI: 10.1111/clr.70050

Francesco Cairo, Cosimo Rupe, Raffaele Cavalcanti, Luca Landi, Antonio Rupe, Nicola Marco Sforza, Walter Castelluzzo, Maria Di Martino, Luigi Barbato

Aims

To compare the efficacy of cross-linked volume-stable collagen matrix (VCMX) versus connective tissue graft (CTG) to increase buccal peri-implant mucosal thickness (MT) around dental implants.

Methods

The present is a parallel, randomized multi-center clinical trial, according to the CONSORT statement. Clinical centers were four Italian periodontal settings. All patients received a soft tissue augmentation procedure, by means of CTG or VCMX. The primary outcome variable was peri-implant mucosal thickness (MT) difference at 12 months follow-up. The statistical unit was the patient. An analysis of covariance was performed for this outcome variable. Secondary outcomes were patient-reported outcome measures (PROMs), complications, variability among operators, and changes in keratinized mucosa width (KMW).

Results

A total of 98 patients completed the study, 49 in each group. MT increase was 1.0 ± 0.75 in the CTG group and 0.66 ± 0.58 mm in the VCMX group. CTG showed superior results to VCMX for MT gain (0.37 mm, 95% CI: 0.13–0.61, p = 0.002). In cases of Baseline MT ≥ 2 mm, CTG and VCMX yielded comparable results. VCMX was associated with shorter chair time (diff: 10.0 min; 95% CI: 5.02 to 14.98; p < 0.0001). Patients in the VCMX group experienced fewer days of discomfort (0.46 days, 95% CI: 0.06–0.99, p = 0.05), while no differences were found for final aesthetic and general satisfaction (CTG: 99.28 ± 2.28, VCMX: 98.48 ± 3.92, p = 0.22).

Conclusions

Both techniques improved MT, and CTG yielded better outcomes. VCMX was associated with shorter chair time and less postoperative discomfort, but both procedures achieved excellent final patient satisfaction.

目的比较交联体积稳定型胶原基质（VCMX）与结缔组织移植物（CTG）在增加种植体周围口腔黏膜厚度（MT）方面的效果。方法：根据CONSORT声明，本研究是一项平行、随机的多中心临床试验。临床中心是四个意大利牙周设置。所有患者均通过CTG或VCMX接受软组织增强手术。主要结局变量为12个月随访时种植体周围粘膜厚度（MT）差异。统计单位是病人。对该结果变量进行协方差分析。次要结果是患者报告的结果测量值（PROMs）、并发症、操作人员之间的差异和角化粘膜宽度（KMW）的变化。结果共98例患者完成研究，每组49例。CTG组MT增加1.0±0.75 mm， VCMX组MT增加0.66±0.58 mm。CTG在MT增益方面优于VCMX （0.37 mm, 95% CI: 0.13-0.61, p = 0.002）。在基线MT≥2mm的情况下，CTG和VCMX的结果相当。VCMX与较短的坐椅时间相关（差异：10.0 min; 95% CI: 5.02至14.98;p < 0.0001）。VCMX组患者的不适天数较少（0.46天，95% CI: 0.06-0.99, p = 0.05），而最终美学和总体满意度无差异（CTG: 99.28±2.28,VCMX: 98.48±3.92,p = 0.22）。结论两种技术均能改善MT， CTG治疗效果更好。VCMX与更短的坐椅时间和更少的术后不适相关，但两种手术都获得了极好的最终患者满意度。

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引用次数: 0

Does Calcium Phosphate Peri-Implant Grafting Improve Osseointegration of Dental Implants? An Experimental In Vivo Study 磷酸钙种植体周围移植能改善种植体的骨整合吗？一项实验性体内研究。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-16 DOI: 10.1111/clr.70046

F. C. A. Lima, S. De Moraes, S. C. Sartoretto, P. S. Nunes, C. M. S. F. dos Santos, B. Ghiraldini, F. J. B. Bezerra, J. M. Granjeiro, M. D. Calasans-Maia, R. S. Louro

Objective

This in vivo study aimed to evaluate the osseointegration of dental implants with a nanostructured hydroxyapatite (HAnano) coating or a double acid-etched (DAA) surface, grafted with or without calcium phosphate in the peri-implant gap, in low-density bone in a sheep model.

Materials and Methods

Thirty implants (15 HAnano and 15 DAA) were installed in the iliac crest of five sheep (2–4 years old). Six implants were placed per animal: two with a xenograft biomaterial, two with an alloplastic biomaterial, and two without grafting (control). Microtomographic analyses evaluated the percentage of bone and biomaterial for all groups. Histomorphometric analysis assessed bone-implant contact (BIC), bone occupied area fraction (BAFo), and biomaterial presence after an 8-week healing period. Data were analyzed using repeated-measures ANOVA or mixed-effects models with a significance level of 0.05.

Results

No complications were observed during the healing period. The average BIC across all groups was 55%, ranging from 4.6% to 67.7%. BAFo averaged 30%, with biomaterial occupying 22% and connective tissue 44% of the interface area. There were no statistically significant differences between grafted and non-grafted groups for BIC (p = 0.413), BAFo (p = 0.097), connective tissue presence (p = 0.192), and for the percentage of bone and biomaterial (p = 0.959), bone percentage (p = 0.283), or biomaterial percentage (p > 0.0959).

Conclusion

Peri-implant grafting with xenograft or alloplastic biomaterials did not significantly enhance osseointegration compared to ungrafted implants in small peri-implant defects. These results suggest that spontaneous healing may suffice in such cases.

目的：本体内研究旨在评估纳米结构羟基磷灰石（HAnano）涂层或双酸蚀（DAA）表面的牙种植体在低密度骨羊模型中的骨整合，在种植体周围间隙中植入或不植入磷酸钙。材料与方法将30个假体（HAnano 15个，DAA 15个）植入5只2-4岁绵羊的髂骨。每只动物放置6个植入物：2个采用异种移植生物材料，2个采用同种异体生物材料，2个不采用移植（对照组）。显微层析分析评估了所有组的骨和生物材料的百分比。组织形态计量学分析评估骨-种植体接触（BIC）、骨占据面积分数（BAFo）和8周愈合期后生物材料的存在。数据分析采用重复测量方差分析或混合效应模型，显著性水平为0.05。结果愈合期间无并发症发生。所有小组的平均BIC为55%，范围从4.6%到67.7%不等。BAFo平均占30%，生物材料占22%，结缔组织占44%。移植物组与非移植物组在BIC （p = 0.413）、BAFo （p = 0.097）、结缔组织存在（p = 0.192）以及骨和生物材料百分比（p = 0.959）、骨百分比（p = 0.283）或生物材料百分比（p > 0.0959）方面差异均无统计学意义。结论同种异体或同种异体生物材料在种植体周围小缺损中的骨整合效果不明显。这些结果表明，在这种情况下，自发愈合可能就足够了。

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引用次数: 0

Oral Communication 第32届欧洲骨整合协会年度科学会议2025年9月18日至20日。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-15 DOI: 10.1111/clr.70008

引用次数: 0

ePoster 第32届欧洲骨整合协会年度科学会议2025年9月18日至20日。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-15 DOI: 10.1111/clr.70007

引用次数: 0

Dual Growth Factor Release From Collagen Based Multilayer Films on Ti-Surfaces Enhances Periimplant Bone Formation and Angiogenic Activity—An Experimental In-Vivo Study ti表面基于胶原的多层膜释放双重生长因子促进种植周骨形成和血管生成活性——一项体内实验研究

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-12 DOI: 10.1111/clr.70045

Philipp Kauffmann, Susanne Wolfer, Christina Behrens, Pauline Schlosser, Christian Dullin, Uwe Schirmer, Klaus Liefeith, Henning Schliephake

Objectives

The aim of the present study was to assess the effect of dual growth factor release from collagen-based polyelectrolyte multilayer films (PEMs) on titanium implants on periimplant bone formation and angiogenetic activity in minipig mandibles.

Material and Methods

Disc shaped Ti implants (5 × 7 × 1 mm) were coated with polyelectrolyte multilayer films and loaded with rhBMP-2, rhVEGF165, and a combination of both. Uncoated and unloaded Ti implants served as controls. The implants were inserted press-fit into 5 mm trephine cavities in minipig mandibles and evaluated after 4 and 13 weeks for bone formation, bone implant contact, and periimplant expression of CD31.

Results

After 4 weeks, there was no significant difference in periimplant bone formation nor bone-implant contact between the different surface conditions. CD31 expression was significantly increased around PEM coated implants loaded with VEGF and BMP each. After 13 weeks, bone implant contact and bone formation were significantly increased only around PEM coated implants with simultaneous release of BMP-2 and VEGF165. Expression of CD31 was significantly enhanced around all PEM coated implants loaded with growth factors regardless of the type or combination.

Conclusion

It is concluded that simultaneous release of rhBMP-2 and rhVEGF165 may be required to achieve significant improvement of periimplant bone formation and bone implant contact. Angiogenesis as reflected by CD31 expression is enhanced by both rhVEGF165 and rhBMP-2 to a similar extent without an additive effect of simultaneous release.

目的研究胶原基聚电解质多层膜（PEMs）释放双生长因子对微型猪下颌骨种植体周围骨形成和血管生成活性的影响。材料与方法采用聚电解质多层膜包覆片状钛植入物（5 × 7 × 1 mm），并负载rhBMP-2、rhVEGF165或两者的组合。未涂覆和卸载的钛植入物作为对照。将种植体压贴合置入小型猪下颌骨5 mm的环形腔中，在4周和13周后评估骨形成、骨种植体接触和种植体周围CD31的表达。结果4周后，不同表面条件下种植体周围骨形成及骨与种植体接触无显著差异。CD31的表达在分别装载VEGF和BMP的PEM包被植入物周围显著增加。13周后，骨种植体接触和骨形成仅在PEM涂层种植体周围显著增加，同时释放BMP-2和VEGF165。CD31的表达在所有负载生长因子的PEM包被植入物周围显著增强，无论其类型或组合如何。结论需同时释放rhBMP-2和rhVEGF165才能显著改善种植周骨形成和种植体骨接触。通过CD31表达反映的血管生成，rhVEGF165和rhBMP-2均有相似程度的增强，但没有同时释放的叠加效应。

{"title":"Dual Growth Factor Release From Collagen Based Multilayer Films on Ti-Surfaces Enhances Periimplant Bone Formation and Angiogenic Activity—An Experimental In-Vivo Study","authors":"Philipp Kauffmann, Susanne Wolfer, Christina Behrens, Pauline Schlosser, Christian Dullin, Uwe Schirmer, Klaus Liefeith, Henning Schliephake","doi":"10.1111/clr.70045","DOIUrl":"10.1111/clr.70045","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of the present study was to assess the effect of dual growth factor release from collagen-based polyelectrolyte multilayer films (PEMs) on titanium implants on periimplant bone formation and angiogenetic activity in minipig mandibles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Disc shaped Ti implants (5 × 7 × 1 mm) were coated with polyelectrolyte multilayer films and loaded with rhBMP-2, rhVEGF165, and a combination of both. Uncoated and unloaded Ti implants served as controls. The implants were inserted press-fit into 5 mm trephine cavities in minipig mandibles and evaluated after 4 and 13 weeks for bone formation, bone implant contact, and periimplant expression of CD31.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 4 weeks, there was no significant difference in periimplant bone formation nor bone-implant contact between the different surface conditions. CD31 expression was significantly increased around PEM coated implants loaded with VEGF and BMP each. After 13 weeks, bone implant contact and bone formation were significantly increased only around PEM coated implants with simultaneous release of BMP-2 and VEGF165. Expression of CD31 was significantly enhanced around all PEM coated implants loaded with growth factors regardless of the type or combination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>It is concluded that simultaneous release of rhBMP-2 and rhVEGF165 may be required to achieve significant improvement of periimplant bone formation and bone implant contact. Angiogenesis as reflected by CD31 expression is enhanced by both rhVEGF165 and rhBMP-2 to a similar extent without an additive effect of simultaneous release.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 1","pages":"1-17"},"PeriodicalIF":5.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vertical Ridge Augmentation in the Anterior Maxilla Using a Dual-Texture e-PTFE Membrane and Autogenous Bone: A 2- to 5-Year Retrospective Case-Series Study 使用双纹理e - PTFE膜和自体骨在前上颌垂直嵴增强：一项2 - 5年回顾性病例系列研究

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-11 DOI: 10.1111/clr.70044

David González, Herman Sahlin, Christer Dahlin

Objectives

To evaluate a novel protocol for vertical ridge augmentation with titanium-(Ti)-reinforced dual-texture expanded polytetrafluoroethylene (e-PTFE) membranes, 100% autogenous bone, and 12 months of bone healing in the anterior maxilla.

Material and Methods

This retrospective study included 14 consecutive patients treated between 2016 and 2021. Large defects, including both vertical and horizontal components, were treated with autogenous bone grafting and non-resorbable Ti-reinforced dual-texture e-PTFE membranes. Implants were placed in the augmented bone after 12 months. All clinical and radiographical parameters were retrieved from patient records.

Results

The case series included 14 patients treated with 15 e-PTFE membranes. The mean initial vertical defect size was 7.5 ± 5.1 mm (range: 3–23 mm). All membranes remained unexposed during the entire healing period (12.6 ± 1.2 months). No complications that needed intervention occurred. Complete bone fill was achieved, that is, regenerated bone filled the entire volume created by the membrane, in all treated defects. Twenty-three implants were placed. The survival rate was 100% and the mean marginal bone level was 0.08 ± 0.11 mm after up to 5 years.

Conclusions

Excellent vertical augmentation outcomes can be achieved in the anterior maxilla using a non-resorbable Ti-reinforced e-PTFE membrane and an autogenous bone graft, followed by 12 months of healing before implant placement. The implants demonstrated stable marginal bone levels after loading. This case series has limitations, mainly the retrospective nature and small sample size, but it indicates that the proper choice of methods, materials, and healing times during GBR results in a predictable clinical outcome.

目的：评价一种采用钛（Ti）增强双纹理膨胀聚四氟乙烯（e - PTFE）膜、100%自体骨和上颌前牙12个月骨愈合的垂直嵴增强新方案。材料和方法本回顾性研究纳入了2016年至2021年间连续治疗的14例患者。大的缺陷，包括垂直和水平的组件，用自体植骨和不可吸收的钛增强双纹理e - PTFE膜进行治疗。12个月后将植入物放置在增强骨中。从患者记录中检索所有临床和影像学参数。结果14例患者接受了15个e - PTFE膜治疗。平均初始垂直缺陷尺寸为7.5±5.1 mm（范围：3-23 mm）。所有膜在整个愈合期间（12.6±1.2个月）均未暴露。未发生需要干预的并发症。在所有处理过的缺损中，实现了完全的骨填充，即再生骨填充了由膜产生的整个体积。共植入了23个植入物。术后5年生存率为100%，平均骨缘水平为0.08±0.11 mm。结论采用不可吸收性钛增强膜和自体骨移植可获得良好的上颌骨垂直增强效果，种植体植入术前愈合12个月。植入物在加载后表现出稳定的边缘骨水平。该病例系列具有局限性，主要是回顾性和小样本量，但它表明，在GBR中正确选择方法、材料和愈合时间可导致可预测的临床结果。

{"title":"Vertical Ridge Augmentation in the Anterior Maxilla Using a Dual-Texture e-PTFE Membrane and Autogenous Bone: A 2- to 5-Year Retrospective Case-Series Study","authors":"David González, Herman Sahlin, Christer Dahlin","doi":"10.1111/clr.70044","DOIUrl":"10.1111/clr.70044","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate a novel protocol for vertical ridge augmentation with titanium-(Ti)-reinforced dual-texture expanded polytetrafluoroethylene (e-PTFE) membranes, 100% autogenous bone, and 12 months of bone healing in the anterior maxilla.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This retrospective study included 14 consecutive patients treated between 2016 and 2021. Large defects, including both vertical and horizontal components, were treated with autogenous bone grafting and non-resorbable Ti-reinforced dual-texture e-PTFE membranes. Implants were placed in the augmented bone after 12 months. All clinical and radiographical parameters were retrieved from patient records.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The case series included 14 patients treated with 15 e-PTFE membranes. The mean initial vertical defect size was 7.5 ± 5.1 mm (range: 3–23 mm). All membranes remained unexposed during the entire healing period (12.6 ± 1.2 months). No complications that needed intervention occurred. Complete bone fill was achieved, that is, regenerated bone filled the entire volume created by the membrane, in all treated defects. Twenty-three implants were placed. The survival rate was 100% and the mean marginal bone level was 0.08 ± 0.11 mm after up to 5 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Excellent vertical augmentation outcomes can be achieved in the anterior maxilla using a non-resorbable Ti-reinforced e-PTFE membrane and an autogenous bone graft, followed by 12 months of healing before implant placement. The implants demonstrated stable marginal bone levels after loading. This case series has limitations, mainly the retrospective nature and small sample size, but it indicates that the proper choice of methods, materials, and healing times during GBR results in a predictable clinical outcome.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 12","pages":"1664-1674"},"PeriodicalIF":5.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Additional Cover 额外的封面

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-10 DOI: 10.1111/clr.70043

The cover 3 image is based on the article Bi-Layered Biphasic Calcium Phosphate Bone Substitute to Improve Bone Formation in Lateral Jaw Defects Applying the Principle of Guided Bone Regeneration (GBR)â€”A Pre-Clinical Randomized Controlled Study by Kiri N. Lang et al., https://doi.org/10.1111/clr.14460.

封面3的图片是基于Kiri N. Lang等人的文章《应用引导骨再生（GBR）原理改善侧颌缺损骨形成的双层双相钙磷酸盐骨替代物——临床前随机对照研究https://doi.org/10.1111/clr.14460》。

引用次数: 0

Additional Cover 额外的封面

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-10 DOI: 10.1111/clr.70042

The cover 2 image is based on the article Ridge Preservation in Extraction Sockets of Periodontally Compromised Molars With and Without Primary Wound Closure: Histological and 1-Year Implant Outcomes of a Clinical Trial by Yiping Wei et al., https://doi.org/10.1111/clr.14459.

封面2的图片是基于魏一平等人的文章《牙周受损磨牙牙槽的牙嵴保存：组织学和1年种植体临床试验结果》（https://doi.org/10.1111/clr.14459）。

引用次数: 0

Role of Local Factors on the Occurrence of Peri-Implantitis: A Cross-Sectional Analysis 局部因素在种植体周围炎发生中的作用：横断面分析。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-08 DOI: 10.1111/clr.70036

Alberto Monje, Ramon Pons, Maria Costanza Soldini, Paul S. Rosen, José Nart, Daniel Buser

Objective

A cross-sectional study was made to evaluate the role of local factors, including surgical, implant, and prosthesis-related parameters, in the presence of peri-implantitis.

Methods

Consecutive partially edentulous patients with ≥ 1 implant presenting peri-implantitis were included. Clinical and radiographic data were collected to characterize local factors. Overall, 28 site-specific variables were analyzed for peri-implantitis and non-peri-implantitis implants. Simple and multiple logistic regression analyses were performed to explore potential associations. The diagnostic accuracy of those variables that demonstrated statistical significance in the multiple logistic regression analysis was further tested.

Results

In total, 100 patients with 452 implants met the inclusion criteria. Of these, 227 implants (50.2%) were diagnosed with peri-implantitis, while 225 (49.8%) did not present peri-implantitis. The multiple logistic regression analysis demonstrated statistical significance for the following factors: (1) medial implant position within the prosthesis (OR = 3.9) was more prone to develop peri-implantitis; (2) internal Morse taper implant connection was the least likely to develop peri-implantitis (OR = 0.43); (3) mesio-distally centered implants were less prone to exhibit peri-implantitis (OR = 0.46); (4) bucco-lingual centered implants were less prone to exhibit peri-implantitis (OR = 0.29); (5) implants positioned inside (≥ 2 mm) the bony housing were less prone to exhibit peri-implantitis (OR = 0.13); and (6) implants tilted 10°–30° (OR = 5.84) and ≥ 30° (OR = 7.43) were more prone to exhibit peri-implantitis. Moreover, a prediction model based on the aforementioned factors yielded a high level of accuracy.

Conclusions

Implant malpositioning is a critical factor associated with peri-implantitis.

目的：通过一项横断面研究来评估局部因素（包括手术、种植体和假体相关参数）在种植体周围炎中的作用。方法纳入连续出现种植体≥1颗的部分无牙患者。收集临床和影像学资料以确定局部因素。总的来说，28个位点特异性变量分析了种植体周围炎和非种植体周围炎种植体。进行简单和多元逻辑回归分析以探索潜在的关联。进一步检验多元逻辑回归分析中具有统计学意义的变量的诊断准确性。结果100例患者共452颗种植体符合纳入标准。其中，227个种植体（50.2%）被诊断为种植体周围炎，而225个（49.8%）未出现种植体周围炎。多元logistic回归分析显示以下因素具有统计学意义：(1)种植体内内侧位置（OR = 3.9）更容易发生种植体周围炎；(2)内莫尔斯锥度种植体连接最不容易发生种植体周围炎（OR = 0.43）；(3)中远端为中心的种植体不容易出现种植体周围炎（OR = 0.46）；(4)颊-舌中心种植体较不容易出现种植体周围炎（OR = 0.29）；(5)位于骨壳内（≥2mm）的种植体不容易出现种植体周围炎（OR = 0.13）；(6)种植体倾斜10°-30°（OR = 5.84）和≥30°（OR = 7.43）的种植体更容易出现种植体周围炎。此外，基于上述因素的预测模型产生了高水平的准确性。结论种植体错位是引起种植体周围炎的重要因素。

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