首页 > 最新文献

Clinical Oral Implants Research最新文献

英文 中文
Immunohistological Evaluation of Peri-Implant Soft Tissue Grafting Using a Porcine Dermal Matrix-A Human Histological Study. 利用猪真皮基质进行种植体周围软组织移植的免疫组织学评价-人类组织学研究。
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-30 DOI: 10.1111/clr.70088
F R S Michallek,M Sluka,V C Landwehr,K Vach,L Larsson,K Nelson,S Nahles,F Kernen,G Iglhaut,T Fretwurst
INTRODUCTIONThe aim was the immunohistological evaluation of a porcine dermal matrix (PDM) in comparison to a non-augmented control group for peri-implant tissue thickening.MATERIALS AND METHODSThis human histological study involved the placement of PDM in the test group (20 patients) during implant placement, while the control group underwent implant placement without grafting (20 patients). Postoperative clinical evaluations were conducted, and biopsies were obtained after 3 months. Histomorphometric evaluation utilized H&E staining. Immunohistological analysis included CD31, PSR, TE-7, CD3, CD20, CD138, and CD68.RESULTSA total of 40 patients (17 females, 23 males; 60.62 years) were included. Though more frequent gingival redness occurred during wound healing in the PDM, the groups showed no significant differences in epithelial thickness (p = 0.63), rete ridges (p = 0.53), papilla density (p = 0.626), papilla complexity (p = 0.053), vascularization (p = 0.052), connective tissue morphology (p = 0.127), collagen differentiation (p = 0.41), and CD3+ (p = 0.85) and CD138+ cells (p = 0.33). The PDM group showed significantly more CD68+ cells (p = 0.049) and CD20+ cells (p = 0.046), which correlates with a potentially distinct immune response caused by the PDM.CONCLUSIONThe PDM used in this study exhibited no significant differences regarding epithelial changes, vascularization, tissue morphology, and collagen differentiation compared to a healthy control sample 3 months after grafting. The PDM group demonstrated a significantly higher frequency of CD68+ and CD20+ cells. The noticeable interindividual variation in immunoprofiles and clinical relevance of these findings should be investigated in future research.
目的是对猪真皮基质(PDM)进行免疫组织学评估,并与未增强的对照组进行比较,以评估种植体周围组织增厚的情况。材料与方法本人体组织学研究,试验组(20例)在种植体植入过程中植入PDM,对照组(20例)在种植体植入过程中不移植。术后进行临床评价,3个月后行活检。组织形态学评价采用H&E染色。免疫组织学分析包括CD31、PSR、TE-7、CD3、CD20、CD138和CD68。结果共纳入40例患者,其中女性17例,男性23例,年龄60.62岁。虽然PDM患者在伤口愈合过程中更频繁地出现牙龈发红,但两组在上皮厚度(p = 0.63)、视网膜嵴(p = 0.53)、乳头密度(p = 0.626)、乳头复杂性(p = 0.053)、血管形成(p = 0.052)、结缔组织形态(p = 0.127)、胶原分化(p = 0.41)、CD3+ (p = 0.85)和CD138+细胞(p = 0.33)方面均无显著差异。PDM组CD68+细胞(p = 0.049)和CD20+细胞(p = 0.046)明显增多,这与PDM引起的潜在不同免疫反应相关。结论本研究中使用的PDM在移植后3个月与健康对照样本相比,在上皮变化、血管形成、组织形态和胶原分化方面没有显著差异。PDM组CD68+和CD20+细胞的频率显著高于PDM组。免疫谱的显著个体间差异和这些发现的临床相关性应在未来的研究中进行调查。
{"title":"Immunohistological Evaluation of Peri-Implant Soft Tissue Grafting Using a Porcine Dermal Matrix-A Human Histological Study.","authors":"F R S Michallek,M Sluka,V C Landwehr,K Vach,L Larsson,K Nelson,S Nahles,F Kernen,G Iglhaut,T Fretwurst","doi":"10.1111/clr.70088","DOIUrl":"https://doi.org/10.1111/clr.70088","url":null,"abstract":"INTRODUCTIONThe aim was the immunohistological evaluation of a porcine dermal matrix (PDM) in comparison to a non-augmented control group for peri-implant tissue thickening.MATERIALS AND METHODSThis human histological study involved the placement of PDM in the test group (20 patients) during implant placement, while the control group underwent implant placement without grafting (20 patients). Postoperative clinical evaluations were conducted, and biopsies were obtained after 3 months. Histomorphometric evaluation utilized H&E staining. Immunohistological analysis included CD31, PSR, TE-7, CD3, CD20, CD138, and CD68.RESULTSA total of 40 patients (17 females, 23 males; 60.62 years) were included. Though more frequent gingival redness occurred during wound healing in the PDM, the groups showed no significant differences in epithelial thickness (p = 0.63), rete ridges (p = 0.53), papilla density (p = 0.626), papilla complexity (p = 0.053), vascularization (p = 0.052), connective tissue morphology (p = 0.127), collagen differentiation (p = 0.41), and CD3+ (p = 0.85) and CD138+ cells (p = 0.33). The PDM group showed significantly more CD68+ cells (p = 0.049) and CD20+ cells (p = 0.046), which correlates with a potentially distinct immune response caused by the PDM.CONCLUSIONThe PDM used in this study exhibited no significant differences regarding epithelial changes, vascularization, tissue morphology, and collagen differentiation compared to a healthy control sample 3 months after grafting. The PDM group demonstrated a significantly higher frequency of CD68+ and CD20+ cells. The noticeable interindividual variation in immunoprofiles and clinical relevance of these findings should be investigated in future research.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"3 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peri-Implant Crevicular Fluid Analysis by Mid-Infrared Spectroscopy in Peri-Implantitis-A Pilot Study. 中红外光谱分析种植体周围沟液的初步研究。
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-22 DOI: 10.1111/clr.70091
Francisco Maligno,Ricardo N M J Páscoa,Pedro S Gomes
OBJECTIVESThis study aimed to assess biochemical differences in peri-implant crevicular fluid (PICF) using ATR-FTIR spectroscopy and multivariate analysis, through a between-participant comparison of healthy and peri-implantitis (PI) sites, and a within-participant comparison of PI-PICF and GCF from contralateral periodontal healthy teeth.MATERIALS AND METHODSSamples were categorized into three groups based on peri-implant status and sampling site: PICF from peri-implant healthy sites, PICF from PI-affected sites, and GCF from contralateral healthy teeth in PI patients, with n = 20/group. Samples were collected and analyzed through ATR-FTIR spectroscopy. Chemometric models were applied for cluster/outlier identification and discrimination. Regression coefficient vectors of PLS-DA models identified key spectral differences between groups.RESULTSA total of 40 implants were analyzed; participants had a mean age of 62 years, predominantly female (59%), non-smokers (88%), and most received regular maintenance therapy (82%). PCA revealed subtle cluster formations without clear group separation. Comparing PICF from patients with and without PI, the most important wavenumbers for the PLS-DA model were within 1700-1680 cm-1, 1190-1130 cm-1, and 1050-980 cm-1, associated with protein-related signals and nucleic-acid content. Comparing the GCF and PICF from PI patients, using a split-mouth design, the most important wavenumbers were 3006 cm-1, 2982 cm-1, and 2900 cm-1, related to lipid structures. In terms of accuracy, between-participant assessment achieved 75%, whereas the split-mouth assessment reached 83.4%.CONCLUSIONSFTIR-spectroscopy combined with chemometric modeling effectively discriminates peri-implant health and PI in both inter- and intra-subject comparisons. Higher within-subject accuracy supports FTIR's potential as a site-specific, non-invasive diagnostic tool for peri-implantitis.
目的:本研究旨在通过对健康和种植周炎(PI)部位的参与者间比较,以及对侧牙周健康牙齿PI-PICF和GCF的参与者内比较,利用ATR-FTIR光谱和多变量分析来评估种植周沟液(PICF)的生化差异。材料与方法将样本根据种植周健康部位PICF、PI影响部位PICF和PI患者对侧健康牙GCF分为3组,每组20例。样品采集并通过ATR-FTIR光谱分析。化学计量模型应用于聚类/离群值识别和区分。PLS-DA模型的回归系数向量确定了各组间的关键光谱差异。结果共对40颗种植体进行了tsa分析;参与者的平均年龄为62岁,主要是女性(59%),不吸烟(88%),大多数接受定期维持治疗(82%)。PCA显示细微的团簇形成,没有明显的群分离。比较PI患者和非PI患者的PICF, PLS-DA模型最重要的波数在1700-1680 cm-1、1190-1130 cm-1和1050-980 cm-1范围内,与蛋白质相关信号和核酸含量相关。比较PI患者的GCF和PICF,采用裂口设计,最重要的波数为3006 cm-1、2982 cm-1和2900 cm-1,与脂质结构有关。在准确率方面,参与者间评估达到75%,而口裂评估达到83.4%。结论sftir光谱结合化学计量模型在受试者之间和受试者内部比较中都能有效区分种植体周围健康和PI。更高的受试者内准确性支持FTIR作为种植体周围炎的部位特异性非侵入性诊断工具的潜力。
{"title":"Peri-Implant Crevicular Fluid Analysis by Mid-Infrared Spectroscopy in Peri-Implantitis-A Pilot Study.","authors":"Francisco Maligno,Ricardo N M J Páscoa,Pedro S Gomes","doi":"10.1111/clr.70091","DOIUrl":"https://doi.org/10.1111/clr.70091","url":null,"abstract":"OBJECTIVESThis study aimed to assess biochemical differences in peri-implant crevicular fluid (PICF) using ATR-FTIR spectroscopy and multivariate analysis, through a between-participant comparison of healthy and peri-implantitis (PI) sites, and a within-participant comparison of PI-PICF and GCF from contralateral periodontal healthy teeth.MATERIALS AND METHODSSamples were categorized into three groups based on peri-implant status and sampling site: PICF from peri-implant healthy sites, PICF from PI-affected sites, and GCF from contralateral healthy teeth in PI patients, with n = 20/group. Samples were collected and analyzed through ATR-FTIR spectroscopy. Chemometric models were applied for cluster/outlier identification and discrimination. Regression coefficient vectors of PLS-DA models identified key spectral differences between groups.RESULTSA total of 40 implants were analyzed; participants had a mean age of 62 years, predominantly female (59%), non-smokers (88%), and most received regular maintenance therapy (82%). PCA revealed subtle cluster formations without clear group separation. Comparing PICF from patients with and without PI, the most important wavenumbers for the PLS-DA model were within 1700-1680 cm-1, 1190-1130 cm-1, and 1050-980 cm-1, associated with protein-related signals and nucleic-acid content. Comparing the GCF and PICF from PI patients, using a split-mouth design, the most important wavenumbers were 3006 cm-1, 2982 cm-1, and 2900 cm-1, related to lipid structures. In terms of accuracy, between-participant assessment achieved 75%, whereas the split-mouth assessment reached 83.4%.CONCLUSIONSFTIR-spectroscopy combined with chemometric modeling effectively discriminates peri-implant health and PI in both inter- and intra-subject comparisons. Higher within-subject accuracy supports FTIR's potential as a site-specific, non-invasive diagnostic tool for peri-implantitis.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"103 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-Year Analysis of Clinical and Radiological Outcomes of Two-Piece Zirconia Compared to Titanium Implants: A Multicenter Prospective Randomized Clinical Trial. 一项多中心前瞻性随机临床试验:两片式氧化锆与钛种植体为期一年的临床和放射学结果分析。
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-22 DOI: 10.1111/clr.70094
Marc Balmer,Michael Payer,Anke Steinwender,Valentin Herber,Ronald E Jung,Sebastian Kühl
OBJECTIVESTo evaluate the clinical performance of two-piece zirconia implants with screw-retained abutments compared to titanium implants after 1 year of loading.MATERIALS AND METHODSIn this multicenter, prospective, randomized clinical trial, 61 two-piece zirconia and 61 titanium implants were placed and restored with single crowns. Evaluations were performed at implant placement, crown delivery, and 1-year post-loading. Peri-implant Marginal Bone Loss (MBL), survival rate, early wound healing index, and soft tissue parameters were assessed. Intergroup comparisons of continuous outcomes were performed using Linear Mixed-Effects Models accounting for center and potential confounders. Categorical variables were analyzed using the chi-square or Fisher's exact test. Survival was analyzed using Kaplan-Meier estimates. Significance was set at p < 0.05.RESULTSNo significant differences were found between the two implant types. Mean MBL from implantation to crown insertion was 1.10 ± 0.78 mm for titanium and 0.94 ± 0.67 mm for zirconia implants. No significant additional bone loss occurred over the subsequent year, with changes of 0.07 ± 0.55 mm and 0.08 ± 0.51 mm for titanium and zirconia, respectively. After 1 year, zirconia implants showed a 100% survival rate, while titanium implants showed 96.5% with two failures. At 1 year, differences in probing depths, plaque accumulation, and Papilla Bleeding Index were not statistically significant.CONCLUSIONAfter 1 year of loading, no statistically significant differences in MBL, implant survival, or peri-implant health were found between zirconia and titanium implants, indicating no clinical superiority. Zirconia implants may therefore be considered a viable alternative in single-tooth implant restorations.TRIAL REGISTRATIONThe study is registered at the German Clinical Trial Register (No. DRKS 00013209) as well as at the Federal Office of Public Health's (FOPH) portal for human research in Switzerland (kofam.ch).
目的比较两片式氧化锆固定基牙与钛基牙1年后的临床表现。材料与方法在这项多中心、前瞻性、随机临床试验中,61例二片式氧化锆种植体和61例钛种植体置入和单冠修复。在种植体放置、冠交付和装填后1年进行评估。评估种植体周围边缘骨丢失(MBL)、存活率、早期创面愈合指数和软组织参数。使用线性混合效应模型对连续结果进行组间比较,考虑中心和潜在混杂因素。分类变量分析使用卡方检验或费雪精确检验。生存率分析采用Kaplan-Meier估计法。p < 0.05为显著性。结果两种种植体间无明显差异。钛种植体从种植到冠插入的平均MBL为1.10±0.78 mm,氧化锆种植体为0.94±0.67 mm。在接下来的一年里,没有出现明显的骨质流失,钛和氧化锆的骨质流失分别为0.07±0.55 mm和0.08±0.51 mm。1年后,氧化锆种植体的成活率为100%,钛种植体的成活率为96.5%,有2次失败。1年时,探查深度、斑块积累和乳头出血指数的差异无统计学意义。结论加载1年后,氧化锆种植体与钛种植体在MBL、种植体存活、种植体周围健康方面无统计学差异,无临床优势。因此,氧化锆种植体可以被认为是单牙种植体修复的可行选择。试验注册:该研究已在德国临床试验注册中心注册。DRKS 00013209)以及瑞士联邦公共卫生局(FOPH)人体研究门户网站(kofam.ch)。
{"title":"One-Year Analysis of Clinical and Radiological Outcomes of Two-Piece Zirconia Compared to Titanium Implants: A Multicenter Prospective Randomized Clinical Trial.","authors":"Marc Balmer,Michael Payer,Anke Steinwender,Valentin Herber,Ronald E Jung,Sebastian Kühl","doi":"10.1111/clr.70094","DOIUrl":"https://doi.org/10.1111/clr.70094","url":null,"abstract":"OBJECTIVESTo evaluate the clinical performance of two-piece zirconia implants with screw-retained abutments compared to titanium implants after 1 year of loading.MATERIALS AND METHODSIn this multicenter, prospective, randomized clinical trial, 61 two-piece zirconia and 61 titanium implants were placed and restored with single crowns. Evaluations were performed at implant placement, crown delivery, and 1-year post-loading. Peri-implant Marginal Bone Loss (MBL), survival rate, early wound healing index, and soft tissue parameters were assessed. Intergroup comparisons of continuous outcomes were performed using Linear Mixed-Effects Models accounting for center and potential confounders. Categorical variables were analyzed using the chi-square or Fisher's exact test. Survival was analyzed using Kaplan-Meier estimates. Significance was set at p < 0.05.RESULTSNo significant differences were found between the two implant types. Mean MBL from implantation to crown insertion was 1.10 ± 0.78 mm for titanium and 0.94 ± 0.67 mm for zirconia implants. No significant additional bone loss occurred over the subsequent year, with changes of 0.07 ± 0.55 mm and 0.08 ± 0.51 mm for titanium and zirconia, respectively. After 1 year, zirconia implants showed a 100% survival rate, while titanium implants showed 96.5% with two failures. At 1 year, differences in probing depths, plaque accumulation, and Papilla Bleeding Index were not statistically significant.CONCLUSIONAfter 1 year of loading, no statistically significant differences in MBL, implant survival, or peri-implant health were found between zirconia and titanium implants, indicating no clinical superiority. Zirconia implants may therefore be considered a viable alternative in single-tooth implant restorations.TRIAL REGISTRATIONThe study is registered at the German Clinical Trial Register (No. DRKS 00013209) as well as at the Federal Office of Public Health's (FOPH) portal for human research in Switzerland (kofam.ch).","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"42 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Clinical, Radiographic and Esthetic Outcomes of Zirconia Dental Implants: A 10-Year Prospective Multicenter Study. 氧化锆牙种植体的长期临床、放射学和美学结果:一项10年前瞻性多中心研究。
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-22 DOI: 10.1111/clr.70089
S Roehling,K H Bormann,M M Bornstein,S Laval,F Thieringer,M Gahlert
OBJECTIVESThis study aimed to prospectively investigate the long-term clinical performance of a commercially available one-piece zirconia dental implant system over 10 years.MATERIAL AND METHODSA multicenter, open-label study was conducted at three clinical centers in Germany. Forty-four patients with single-tooth gaps meeting specific inclusion criteria received 44 yttria-stabilized zirconia (Y-TZP) implants featuring a sandblasted and acid-etched (ZLA) surface. Clinical and radiographic follow-ups were performed at 1, 3, 5, and 10 years to assess implant survival, success, peri-implant bone levels, and esthetic outcomes using Pink Esthetic Score (PES) and White Esthetic Score (WES).RESULTSAt the 10-year follow-up, 35 patients with 35 implants were available for evaluation. The estimated 10-year survival rate was 97.7% (95% CI: 97.27-98.13). Three implants (8.6%) showed biological complications, including peri-implant mucositis in 2 implants (5.7%) and peri-implantitis in 1 implant (2.9%), leading to a success rate of 91.4% (95% CI: 76.9-97.8). Peri-implant bone loss was moderate, averaging 1.20 (±0.61) mm over 10 years, with stable bone levels observed after the initial remodeling phase. Esthetic outcomes revealed a slight increase in PES (7.4 to 7.8) and a minor decrease in WES (7.0 to 6.7) between years 5 and 10.CONCLUSIONSZirconia implants demonstrated high long-term survival and success rates, moderate bone loss, and favorable esthetic outcomes. These findings support their use as a clinically reliable and esthetically acceptable long-term alternative to titanium implants. However, the limited sample size highlights the need for further confirmation in larger cohorts.
目的:本研究旨在前瞻性地研究一种市售的一体式氧化锆种植体系统在10年内的长期临床表现。材料与方法在德国的三个临床中心进行了一项多中心、开放标签的研究。44例符合特定纳入标准的单牙间隙患者接受了44例氧化钇稳定氧化锆(Y-TZP)种植体,其表面喷砂和酸蚀(ZLA)。随访时间分别为1年、3年、5年和10年,采用粉色美学评分(PES)和白色美学评分(WES)评估种植体存活、成功、种植体周围骨水平和美学结果。结果随访10年,35例患者35枚种植体可用于评估。估计10年生存率为97.7% (95% CI: 97.27-98.13)。3例(8.6%)种植体出现生物学并发症,其中种植体周围黏膜炎2例(5.7%),种植体周围炎1例(2.9%),成功率91.4% (95% CI: 76.9 ~ 97.8)。种植体周围骨丢失中度,10年内平均1.20(±0.61)mm,在初始重塑期后观察到稳定的骨水平。美学结果显示,在5至10年间,PES略有增加(7.4至7.8),WES略有下降(7.0至6.7)。结论szirconia种植体长期存活率高,成功率高,骨量损失适中,美观效果好。这些发现支持它们作为临床可靠和美观可接受的长期替代钛植入物的使用。然而,有限的样本量强调需要在更大的队列中进一步确认。
{"title":"Long-Term Clinical, Radiographic and Esthetic Outcomes of Zirconia Dental Implants: A 10-Year Prospective Multicenter Study.","authors":"S Roehling,K H Bormann,M M Bornstein,S Laval,F Thieringer,M Gahlert","doi":"10.1111/clr.70089","DOIUrl":"https://doi.org/10.1111/clr.70089","url":null,"abstract":"OBJECTIVESThis study aimed to prospectively investigate the long-term clinical performance of a commercially available one-piece zirconia dental implant system over 10 years.MATERIAL AND METHODSA multicenter, open-label study was conducted at three clinical centers in Germany. Forty-four patients with single-tooth gaps meeting specific inclusion criteria received 44 yttria-stabilized zirconia (Y-TZP) implants featuring a sandblasted and acid-etched (ZLA) surface. Clinical and radiographic follow-ups were performed at 1, 3, 5, and 10 years to assess implant survival, success, peri-implant bone levels, and esthetic outcomes using Pink Esthetic Score (PES) and White Esthetic Score (WES).RESULTSAt the 10-year follow-up, 35 patients with 35 implants were available for evaluation. The estimated 10-year survival rate was 97.7% (95% CI: 97.27-98.13). Three implants (8.6%) showed biological complications, including peri-implant mucositis in 2 implants (5.7%) and peri-implantitis in 1 implant (2.9%), leading to a success rate of 91.4% (95% CI: 76.9-97.8). Peri-implant bone loss was moderate, averaging 1.20 (±0.61) mm over 10 years, with stable bone levels observed after the initial remodeling phase. Esthetic outcomes revealed a slight increase in PES (7.4 to 7.8) and a minor decrease in WES (7.0 to 6.7) between years 5 and 10.CONCLUSIONSZirconia implants demonstrated high long-term survival and success rates, moderate bone loss, and favorable esthetic outcomes. These findings support their use as a clinically reliable and esthetically acceptable long-term alternative to titanium implants. However, the limited sample size highlights the need for further confirmation in larger cohorts.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"47 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Accuracy of Deep Learning Models in Detecting Peri-Implant Marginal Bone Loss: A Systematic Review and Meta-Analysis. 深度学习模型检测种植体周围边缘骨丢失的诊断准确性:系统回顾和荟萃分析。
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-21 DOI: 10.1111/clr.70090
Momen A Atieh,Maanas Shah,Abeer Hakam,Fawaghi AlAli,Samhar AlSayed,Andrew Tawse-Smith,Nabeel H M Alsabeeha
BACKGROUNDPeri-implantitis is a common implant complication requiring early detection to prevent bone loss and implant failure. Deep learning models show promise for enhancing radiographic diagnosis.OBJECTIVESThis review systematically evaluated the diagnostic performance of deep learning models in detecting peri-implant marginal bone loss on radiographic images.MATERIALS AND METHODSA comprehensive search of PubMed, EMBASE, CENTRAL, ClinicalTrials.gov, and ProQuest identified studies published between 2010 and July 2025. Two reviewers independently screened studies, extracted data, and assessed methodological quality using QUADAS-2. Diagnostic metrics, including sensitivity, specificity, F1-score, area under the curve (AUC), were synthesized using random-effects meta-analysis. Heterogeneity and publication bias were evaluated using I2 statistics, meta-regression, and funnel plots.RESULTSFive studies comprising 12,545 periapical and panoramic radiographs met inclusion criteria. Deep learning models achieved pooled sensitivity of 88%, specificity of 91%, and AUC of 0.95, indicating high diagnostic performance. Positive and negative likelihood ratios suggested strong clinical utility. Quality was generally good, though reporting of implant characteristics and data augmentation was inconsistent. Meta-regression revealed that dataset size and unit of analysis influenced accuracy, whereas imaging type did not. No publication bias was found.CONCLUSIONDeep learning models demonstrate high accuracy in detecting radiographic marginal bone loss, potentially indicating peri-implantitis but cannot substitute for comprehensive clinical assessment.CLINICAL RELEVANCEThese models offer a promising adjunct for radiographic detection of marginal bone loss, supporting clinicians in early diagnosis and timely interventions.
背景:种植体周围炎是一种常见的种植体并发症,需要早期发现以防止骨质流失和种植体失效。深度学习模型有望增强放射学诊断。目的:本综述系统评估了深度学习模型在x线图像上检测种植体周围边缘骨丢失的诊断性能。材料和方法对PubMed、EMBASE、CENTRAL、ClinicalTrials.gov和ProQuest进行综合检索,确定了2010年至2025年7月之间发表的研究。两位审稿人独立筛选研究,提取数据,并使用QUADAS-2评估方法学质量。诊断指标,包括敏感性、特异性、f1评分、曲线下面积(AUC),采用随机效应荟萃分析综合。采用I2统计、meta回归和漏斗图评估异质性和发表偏倚。结果5项研究包括12,545张根尖周和全景x线片符合纳入标准。深度学习模型的总灵敏度为88%,特异性为91%,AUC为0.95,具有较高的诊断性能。正似然比和负似然比提示较强的临床应用价值。虽然关于植入物特征和数据增强的报道不一致,但质量总体上是好的。元回归显示数据集大小和分析单位影响准确性,而成像类型不影响。未发现发表偏倚。结论深度学习模型在检测x线边缘骨丢失方面具有较高的准确性,可能提示种植体周围炎,但不能替代临床综合评估。这些模型为边缘骨丢失的影像学检测提供了有希望的辅助手段,支持临床医生进行早期诊断和及时干预。
{"title":"Diagnostic Accuracy of Deep Learning Models in Detecting Peri-Implant Marginal Bone Loss: A Systematic Review and Meta-Analysis.","authors":"Momen A Atieh,Maanas Shah,Abeer Hakam,Fawaghi AlAli,Samhar AlSayed,Andrew Tawse-Smith,Nabeel H M Alsabeeha","doi":"10.1111/clr.70090","DOIUrl":"https://doi.org/10.1111/clr.70090","url":null,"abstract":"BACKGROUNDPeri-implantitis is a common implant complication requiring early detection to prevent bone loss and implant failure. Deep learning models show promise for enhancing radiographic diagnosis.OBJECTIVESThis review systematically evaluated the diagnostic performance of deep learning models in detecting peri-implant marginal bone loss on radiographic images.MATERIALS AND METHODSA comprehensive search of PubMed, EMBASE, CENTRAL, ClinicalTrials.gov, and ProQuest identified studies published between 2010 and July 2025. Two reviewers independently screened studies, extracted data, and assessed methodological quality using QUADAS-2. Diagnostic metrics, including sensitivity, specificity, F1-score, area under the curve (AUC), were synthesized using random-effects meta-analysis. Heterogeneity and publication bias were evaluated using I2 statistics, meta-regression, and funnel plots.RESULTSFive studies comprising 12,545 periapical and panoramic radiographs met inclusion criteria. Deep learning models achieved pooled sensitivity of 88%, specificity of 91%, and AUC of 0.95, indicating high diagnostic performance. Positive and negative likelihood ratios suggested strong clinical utility. Quality was generally good, though reporting of implant characteristics and data augmentation was inconsistent. Meta-regression revealed that dataset size and unit of analysis influenced accuracy, whereas imaging type did not. No publication bias was found.CONCLUSIONDeep learning models demonstrate high accuracy in detecting radiographic marginal bone loss, potentially indicating peri-implantitis but cannot substitute for comprehensive clinical assessment.CLINICAL RELEVANCEThese models offer a promising adjunct for radiographic detection of marginal bone loss, supporting clinicians in early diagnosis and timely interventions.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"29 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implant Therapy in Patients With Neurodegenerative Diseases-A Scoping Review. 神经退行性疾病患者的植入治疗-范围综述
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-19 DOI: 10.1111/clr.70080
Lysandre David,Sabrina Maniewicz,Najla Chebib,Gabriel Gold,Murali Srinivasan,Frauke Müller
OBJECTIVESThe increasing longevity of populations has resulted in a growing number of older adults requiring prosthodontic care, including those with neurodegenerative diseases (NDs). Neurodegenerative diseases pose significant challenges to prosthodontic care, and it remains unclear whether implant therapy in this population achieves outcomes comparable to those observed in the general older population.MATERIALS AND METHODSA first systematic review was reframed to a scoping review using a PCC framework with Population (individuals with neurodegenerative diseases, who were partially or completely edentulous), Concept (implant therapy, planning, placement and maintenance, and any reported complications) and Context (dental and geriatric care settings).RESULTSThe literature search identified 634 studies or case reports, of which none fulfilled the inclusion criteria. Seven papers (1 retrospective study, 2 prospective studies and 4 case reports) outside the inclusion criteria reported on patients with neurodegenerative diseases receiving implants, which suggest that dental implants seem to offer initial benefits in improving chewing efficiency, the quality of life and weight gain, especially in Parkinson's disease (PD) patients. However, their suitability for patients with advanced ND is uncertain.CONCLUSIONAlthough high-level evidence on implant survival and success in patients with neurodegenerative diseases is lacking, the limited available evidence offers promising indications of reasonably successful implant treatments in early-stage cases. However, continuous monitoring of disease progression, oral health and denture management is crucial to retrofit the restoration when necessary.
人口寿命的延长导致越来越多的老年人需要修复护理,包括那些患有神经退行性疾病(NDs)的老年人。神经退行性疾病对修复护理提出了重大挑战,目前尚不清楚在这些人群中种植治疗是否能达到与一般老年人群观察到的结果相当的效果。材料和方法第一次系统评价采用PCC框架进行范围评价,包括人群(患有部分或完全无牙的神经退行性疾病的个体)、概念(种植体治疗、计划、放置和维护,以及任何报告的并发症)和背景(牙科和老年护理机构)。结果检索到634篇研究或病例报告,其中没有一篇符合纳入标准。7篇非纳入标准的论文(1篇回顾性研究,2篇前瞻性研究和4篇病例报告)报道了神经退行性疾病患者接受种植体的情况,这些研究表明,牙种植体似乎在提高咀嚼效率、生活质量和体重增加方面提供了初步的益处,特别是在帕金森病(PD)患者中。然而,它们对晚期ND患者的适用性尚不确定。结论尽管缺乏高水平的神经退行性疾病患者种植体存活和成功的证据,但有限的现有证据为早期病例种植体治疗的合理成功提供了有希望的适应症。然而,持续监测疾病进展、口腔健康和义齿管理是必要时修复义齿的关键。
{"title":"Implant Therapy in Patients With Neurodegenerative Diseases-A Scoping Review.","authors":"Lysandre David,Sabrina Maniewicz,Najla Chebib,Gabriel Gold,Murali Srinivasan,Frauke Müller","doi":"10.1111/clr.70080","DOIUrl":"https://doi.org/10.1111/clr.70080","url":null,"abstract":"OBJECTIVESThe increasing longevity of populations has resulted in a growing number of older adults requiring prosthodontic care, including those with neurodegenerative diseases (NDs). Neurodegenerative diseases pose significant challenges to prosthodontic care, and it remains unclear whether implant therapy in this population achieves outcomes comparable to those observed in the general older population.MATERIALS AND METHODSA first systematic review was reframed to a scoping review using a PCC framework with Population (individuals with neurodegenerative diseases, who were partially or completely edentulous), Concept (implant therapy, planning, placement and maintenance, and any reported complications) and Context (dental and geriatric care settings).RESULTSThe literature search identified 634 studies or case reports, of which none fulfilled the inclusion criteria. Seven papers (1 retrospective study, 2 prospective studies and 4 case reports) outside the inclusion criteria reported on patients with neurodegenerative diseases receiving implants, which suggest that dental implants seem to offer initial benefits in improving chewing efficiency, the quality of life and weight gain, especially in Parkinson's disease (PD) patients. However, their suitability for patients with advanced ND is uncertain.CONCLUSIONAlthough high-level evidence on implant survival and success in patients with neurodegenerative diseases is lacking, the limited available evidence offers promising indications of reasonably successful implant treatments in early-stage cases. However, continuous monitoring of disease progression, oral health and denture management is crucial to retrofit the restoration when necessary.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"30 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pannexin1 Inhibition Suppresses Porphyromonas gingivalis ‐Induced Ferroptosis in Peri‐Implantitis by Regulating the NRF2 / SLC7A11 / GPX4 Pathway Pannexin1抑制通过调控NRF2 / SLC7A11 / GPX4通路抑制牙龈卟啉单胞菌诱导的种植周铁下垂
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-04 DOI: 10.1111/clr.70082
Yujia Wang, Yiyi Zhu, Xingan Wang, Wenqi Su, Jiahong Shi, Cancan Zu, Lang Lei, Houxuan Li
Objectives Pannexin1 (Panx1), a channel‐forming protein, has been implicated in multiple forms of programmed cell death. This study aimed to investigate the role and underlying molecular mechanisms of Panx1 in regulating ferroptosis during peri‐implantitis (PI). Material and Methods Panx1 expression in PI patients was evaluated through bioinformatics analysis and validated using clinical samples. In vitro, Porphyromonas gingivalis ‐stimulated osteoblasts were assessed for changes in Panx1 and ferroptosis‐related markers. After Panx1 inhibition or knockdown, cellular iron content, reactive oxygen species levels, and lipid peroxidation were measured to evaluate ferroptosis. In vivo, a mouse model of P. gingivalis ‐induced PI was established to evaluate the effects of pharmacological Panx1 inhibition on ferroptosis and peri‐implant bone loss. Results Bioinformatic analysis revealed that Panx1 was significantly upregulated in PI tissue. Clinical samples confirmed that Panx1 expression at both gene and protein levels was markedly elevated in PI tissues compared to healthy controls. In vitro, P. gingivalis upregulated Panx1 expression and induced ferroptosis, characterized by increased lipid peroxidation, iron overload, and ROS accumulation. Panx1 inhibition or knockdown alleviated these ferroptosis‐related changes and was associated with the upregulation of the NRF2/SLC7A11/GPX4 antioxidant signaling pathway. In vivo, Panx1‐inhibited PI mice significantly restored the expression of key anti‐ferroptosis proteins in peri‐implant tissues and markedly reduced vertical and circumferential alveolar bone loss around implants compared to untreated PI mice. Conclusions Panx1 inhibition suppressed P. gingivalis ‐induced ferroptosis in PI accompanied by the upregulation of the NRF2/SLC7A11/GPX4 antioxidant pathway. Targeting Panx1 may provide a potential therapeutic strategy for treating PI.
Pannexin1 (Panx1)是一种通道形成蛋白,与多种形式的程序性细胞死亡有关。本研究旨在探讨Panx1在种植体周围炎(PI)中调控铁下垂的作用和潜在的分子机制。材料与方法通过生物信息学分析评估PI患者Panx1的表达,并通过临床样本进行验证。在体外,牙龈卟啉单胞菌刺激的成骨细胞被评估Panx1和铁下垂相关标志物的变化。Panx1抑制或敲除后,测量细胞铁含量、活性氧水平和脂质过氧化水平,以评估铁下垂。在体内,我们建立了牙龈卟啉卟啉诱导的PI小鼠模型,以评估药理Panx1抑制对铁下垂和种植体周围骨质流失的影响。结果生物信息学分析显示,Panx1在PI组织中表达显著上调。临床样本证实,与健康对照组相比,PI组织中基因和蛋白水平的Panx1表达均显著升高。在体外,P. gingivalis上调Panx1表达并诱导铁下垂,其特征是脂质过氧化、铁过载和ROS积累增加。Panx1抑制或敲低减轻了这些铁下垂相关的变化,并与NRF2/SLC7A11/GPX4抗氧化信号通路的上调有关。在体内,与未经治疗的PI小鼠相比,Panx1抑制的PI小鼠显著恢复了种植体周围组织中关键抗铁下垂蛋白的表达,并显著减少了种植体周围垂直和周向的牙槽骨丢失。结论Panx1抑制可抑制P. gingivalis诱导的PI铁下垂,并伴有NRF2/SLC7A11/GPX4抗氧化途径的上调。靶向Panx1可能为治疗PI提供潜在的治疗策略。
{"title":"Pannexin1 Inhibition Suppresses Porphyromonas gingivalis ‐Induced Ferroptosis in Peri‐Implantitis by Regulating the NRF2 / SLC7A11 / GPX4 Pathway","authors":"Yujia Wang, Yiyi Zhu, Xingan Wang, Wenqi Su, Jiahong Shi, Cancan Zu, Lang Lei, Houxuan Li","doi":"10.1111/clr.70082","DOIUrl":"https://doi.org/10.1111/clr.70082","url":null,"abstract":"Objectives Pannexin1 (Panx1), a channel‐forming protein, has been implicated in multiple forms of programmed cell death. This study aimed to investigate the role and underlying molecular mechanisms of Panx1 in regulating ferroptosis during peri‐implantitis (PI). Material and Methods Panx1 expression in PI patients was evaluated through bioinformatics analysis and validated using clinical samples. In vitro, <jats:styled-content style=\"fixed-case\"> <jats:italic>Porphyromonas gingivalis</jats:italic> </jats:styled-content> ‐stimulated osteoblasts were assessed for changes in Panx1 and ferroptosis‐related markers. After Panx1 inhibition or knockdown, cellular iron content, reactive oxygen species levels, and lipid peroxidation were measured to evaluate ferroptosis. In vivo, a mouse model of <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> ‐induced PI was established to evaluate the effects of pharmacological Panx1 inhibition on ferroptosis and peri‐implant bone loss. Results Bioinformatic analysis revealed that Panx1 was significantly upregulated in PI tissue. Clinical samples confirmed that Panx1 expression at both gene and protein levels was markedly elevated in PI tissues compared to healthy controls. In vitro, <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> upregulated Panx1 expression and induced ferroptosis, characterized by increased lipid peroxidation, iron overload, and ROS accumulation. Panx1 inhibition or knockdown alleviated these ferroptosis‐related changes and was associated with the upregulation of the NRF2/SLC7A11/GPX4 antioxidant signaling pathway. In vivo, Panx1‐inhibited PI mice significantly restored the expression of key anti‐ferroptosis proteins in peri‐implant tissues and markedly reduced vertical and circumferential alveolar bone loss around implants compared to untreated PI mice. Conclusions Panx1 inhibition suppressed <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> ‐induced ferroptosis in PI accompanied by the upregulation of the NRF2/SLC7A11/GPX4 antioxidant pathway. Targeting Panx1 may provide a potential therapeutic strategy for treating PI.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"53 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rescue Therapy With Quad Zygoma After Failure of Full-Arch Implant Rehabilitation: A Retrospective Study With a Mean Follow-Up of 8 Years. 全弓植入康复失败后四头颧骨的抢救治疗:一项平均随访8年的回顾性研究。
IF 5.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-02 DOI: 10.1111/clr.70086
Shengchi Fan, Wenjie Zhou, Bilal Al-Nawas, Eduard Valmaseda-Castellón, Rubén Davó

Objectives: To evaluate the long-term clinical outcomes of quad zygomatic implants (ZIs) as a rescue therapy for patients with failed full-arch implant rehabilitation in the maxilla due to advanced peri-implantitis.

Material and methods: This was a retrospective cohort study of all patients treated with the Quad Zygoma Protocol. Primary outcomes included the ZI survival and success rates, and secondary outcomes, the prosthetic success rate and complications.

Results: The study population included 28 consecutive patients who received 112 ZIs between 2006 and 2024, with a mean follow-up of 8.2 ± 4.1 years. In 23 patients, a total of 113 failed conventional implants were removed, and 48 ZIs were immediately placed into the explantation sites. The ZI survival rate was 98.2%, with two ZIs requiring removal due to late complications. The implant success rate was 93.5%, and prosthetic success was achieved in 96.4% of cases. Sinusitis was diagnosed in 8 patients (28.5%) at a mean of 5.92 years postoperatively; all cases were successfully managed medically without implant loss. Soft tissue recession occurred in 9.8% of cases, while oroantral fistula and facial fistula were each observed in 0.9% of implants.

Conclusions: The Quad Zygoma Protocol may represent a reliable and predictable option for the rescue of failed maxillary full-arch implant rehabilitations. Despite a relatively high prevalence of sinusitis, favorable long-term clinical outcomes were achieved with appropriate management.

目的:评价四颧种植体(ZIs)作为上颌全弓种植体康复失败患者因晚期种植体周围炎的抢救治疗的长期临床效果。材料和方法:这是一项回顾性队列研究,纳入了所有接受四头颧骨方案治疗的患者。主要结局包括ZI存活和成功率,次要结局包括假体成功率和并发症。结果:研究人群包括28例患者,在2006年至2024年期间连续接受了112例ZIs,平均随访时间为8.2±4.1年。在23例患者中,共有113个失败的常规植入物被移除,48个ZIs被立即放置到植入部位。ZI生存率为98.2%,2例ZI因晚期并发症需要切除。种植体成功率93.5%,假体成功率96.4%。术后平均5.92年诊断为鼻窦炎8例(28.5%);所有病例均成功处理,无种植体丢失。9.8%的种植体出现软组织退缩,0.9%的种植体出现口窦瘘和面瘘。结论:对于上颌全弓种植体修复失败的患者,四头颧骨方案可能是一种可靠且可预测的选择。尽管鼻窦炎的患病率相对较高,但通过适当的治疗,取得了良好的长期临床结果。
{"title":"Rescue Therapy With Quad Zygoma After Failure of Full-Arch Implant Rehabilitation: A Retrospective Study With a Mean Follow-Up of 8 Years.","authors":"Shengchi Fan, Wenjie Zhou, Bilal Al-Nawas, Eduard Valmaseda-Castellón, Rubén Davó","doi":"10.1111/clr.70086","DOIUrl":"https://doi.org/10.1111/clr.70086","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the long-term clinical outcomes of quad zygomatic implants (ZIs) as a rescue therapy for patients with failed full-arch implant rehabilitation in the maxilla due to advanced peri-implantitis.</p><p><strong>Material and methods: </strong>This was a retrospective cohort study of all patients treated with the Quad Zygoma Protocol. Primary outcomes included the ZI survival and success rates, and secondary outcomes, the prosthetic success rate and complications.</p><p><strong>Results: </strong>The study population included 28 consecutive patients who received 112 ZIs between 2006 and 2024, with a mean follow-up of 8.2 ± 4.1 years. In 23 patients, a total of 113 failed conventional implants were removed, and 48 ZIs were immediately placed into the explantation sites. The ZI survival rate was 98.2%, with two ZIs requiring removal due to late complications. The implant success rate was 93.5%, and prosthetic success was achieved in 96.4% of cases. Sinusitis was diagnosed in 8 patients (28.5%) at a mean of 5.92 years postoperatively; all cases were successfully managed medically without implant loss. Soft tissue recession occurred in 9.8% of cases, while oroantral fistula and facial fistula were each observed in 0.9% of implants.</p><p><strong>Conclusions: </strong>The Quad Zygoma Protocol may represent a reliable and predictable option for the rescue of failed maxillary full-arch implant rehabilitations. Despite a relatively high prevalence of sinusitis, favorable long-term clinical outcomes were achieved with appropriate management.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Abutment Shape on Implant Marginal Bone Remodeling: A Double-Blind, Randomized 24-Month Clinical Study. 基台形状对种植体边缘骨重塑的影响:一项为期24个月的双盲随机临床研究。
IF 5.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-30 DOI: 10.1111/clr.70085
Flavio Seijas Naya, Juan C Bernabeu Mira, Alba Pérez Jardón, Mercedes Conde Amboage, David Peñarrocha Oltra, Fabio Camacho Alonso, Mario Pérez Sayáns

Objective: This study follows a 2-year evaluation to verify marginal bone remodeling (MBR) trends associated with different abutment designs.

Methods: A balanced, randomised, double-blind clinical trial with two parallel experimental arms. 68 implants were placed in 9 men and 12 women, 48.5% using the straight abutment and 51.5% the concave abutment. The primary variable was peri-implant tissue stability, measured by marginal bone loss (MBL) or gain (MBG) through digital radiology. Mixed linear regression models and Additive Generalized Additive Models were constructed to estimate MBR, simultaneously considering the variables abutment height, group, and time.

Results: At 24 months, linear mixed-effects regression models revealed that the concave abutment group exhibited significantly less MBL than the straight abutment group across mesial, distal, and average measurements (p = 0.006-0.026). Significant interactions between abutment type and time at 8 weeks and 6 months suggest early and sustained benefits of the concave design. At 24 months, this effect remained significant except in the mesial model (p = 0.072). Abutment height was positively associated with MBL, particularly in the straight group; however, in the concave group, greater height mitigated bone loss (p < 0.01).

Conclusion: Concave abutments demonstrated a potential advantage in reducing early marginal bone loss and promoting mid-term bone stability compared to straight abutments. Their design may enhance soft tissue adaptation, contributing to improved peri-implant bone preservation. While increased abutment height showed a protective effect in the concave group, these findings require confirmation. Further long-term studies are warranted to validate these results and clarify their clinical relevance.

目的:本研究通过2年的评估来验证与不同基台设计相关的边缘骨重塑(MBR)趋势。方法:一项平衡、随机、双盲的临床试验,有两个平行的实验组。9名男性和12名女性共植入68个种植体,其中48.5%使用直基牙,51.5%使用凹基牙。主要变量是种植体周围组织稳定性,通过数字放射学通过边缘骨损失(MBL)或增加(MBG)来测量。同时考虑基台高度、组和时间等变量,构建了混合线性回归模型和加性广义加性模型来估计MBR。结果:在24个月时,线性混合效应回归模型显示,凹基牙组在近中、远端和平均测量值上的MBL明显低于直基牙组(p = 0.006-0.026)。在8周和6个月时,基台类型和时间之间的显著相互作用表明凹形设计的早期和持续的益处。在24个月时,除中等模型外,这种效果仍然显著(p = 0.072)。基台高度与MBL呈显著正相关,尤其是直牙组;结论:与直基牙相比,凹基牙在减少早期边缘骨丢失和促进中期骨稳定方面具有潜在的优势。它们的设计可以增强软组织的适应性,有助于改善种植体周围的骨保存。虽然增加基台高度对凹组有保护作用,但这些发现还有待证实。需要进一步的长期研究来验证这些结果并阐明其临床相关性。
{"title":"Influence of Abutment Shape on Implant Marginal Bone Remodeling: A Double-Blind, Randomized 24-Month Clinical Study.","authors":"Flavio Seijas Naya, Juan C Bernabeu Mira, Alba Pérez Jardón, Mercedes Conde Amboage, David Peñarrocha Oltra, Fabio Camacho Alonso, Mario Pérez Sayáns","doi":"10.1111/clr.70085","DOIUrl":"https://doi.org/10.1111/clr.70085","url":null,"abstract":"<p><strong>Objective: </strong>This study follows a 2-year evaluation to verify marginal bone remodeling (MBR) trends associated with different abutment designs.</p><p><strong>Methods: </strong>A balanced, randomised, double-blind clinical trial with two parallel experimental arms. 68 implants were placed in 9 men and 12 women, 48.5% using the straight abutment and 51.5% the concave abutment. The primary variable was peri-implant tissue stability, measured by marginal bone loss (MBL) or gain (MBG) through digital radiology. Mixed linear regression models and Additive Generalized Additive Models were constructed to estimate MBR, simultaneously considering the variables abutment height, group, and time.</p><p><strong>Results: </strong>At 24 months, linear mixed-effects regression models revealed that the concave abutment group exhibited significantly less MBL than the straight abutment group across mesial, distal, and average measurements (p = 0.006-0.026). Significant interactions between abutment type and time at 8 weeks and 6 months suggest early and sustained benefits of the concave design. At 24 months, this effect remained significant except in the mesial model (p = 0.072). Abutment height was positively associated with MBL, particularly in the straight group; however, in the concave group, greater height mitigated bone loss (p < 0.01).</p><p><strong>Conclusion: </strong>Concave abutments demonstrated a potential advantage in reducing early marginal bone loss and promoting mid-term bone stability compared to straight abutments. Their design may enhance soft tissue adaptation, contributing to improved peri-implant bone preservation. While increased abutment height showed a protective effect in the concave group, these findings require confirmation. Further long-term studies are warranted to validate these results and clarify their clinical relevance.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145854929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Buccal Bone Dimensional Changes Following Implant Placement and Guided Bone Regeneration With Submerged or Transmucosal Approach: A Cone Beam Computed Tomography Study 种植体植入和引导骨再生后的颊骨尺寸变化与浸没或经粘膜入路:锥束计算机断层扫描研究
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-27 DOI: 10.1111/clr.70083
Haider Alramli, Robert Kelley, Stavros Sofos, Theofilos Koutouzis
Objectives The aim was to compare buccal bone dimensional changes following implant placement with simultaneous guided bone regeneration (GBR), using either a submerged or transmucosal healing approach. Materials and Methods In this randomized, controlled clinical study, twenty‐eight patients with a single implant placed at a restorative‐driven position and with at least 2 mm of the coronal aspect of the implant exposed were allocated to be treated with GBR, either with a submerged healing approach (SBM Group) or a transmucosal healing approach (TSM Group). Cone beam computed tomography (CBCT) studies were taken immediately following treatment (T0) and at 4 months (T1). Vertical bone gain (VGAIN) was the primary outcome variable. Defect resolution, radiographic vertical defect height (RVDH), and radiographic bone thickness (RBT) were evaluated and compared. Results No significant differences were found between the groups for defect height resolution, VGAIN, RVDH, and RBT ( p > 0.05). A significant reduction in RBT was found between T0 and T1 within the groups ( p < 0.05). Conclusion The study found no significant differences in buccal bone dimensional changes between submerged and transmucosal healing approaches when implants were placed with simultaneous GBR.
目的是比较种植体植入后的颊骨尺寸变化与同时引导骨再生(GBR),使用浸入式或经粘膜愈合方法。材料和方法在这项随机对照临床研究中,28名患者将单个种植体放置在修复驱动位置,种植体冠状面暴露至少2mm,被分配接受GBR治疗,要么采用浸入式愈合方法(SBM组),要么采用经黏膜愈合方法(TSM组)。锥形束计算机断层扫描(CBCT)研究在治疗后(T0)和4个月(T1)立即进行。垂直骨增重(VGAIN)是主要结局变量。评估和比较缺陷分辨率、x线摄影垂直缺陷高度(RVDH)和x线摄影骨厚度(RBT)。结果缺损高度分辨力、VGAIN、RVDH、RBT组间差异无统计学意义(p > 0.05)。各组RBT在T0和T1之间显著降低(p < 0.05)。结论种植体同时放置GBR时,浸入式和经黏膜愈合入路的颊骨尺寸变化无显著差异。
{"title":"Buccal Bone Dimensional Changes Following Implant Placement and Guided Bone Regeneration With Submerged or Transmucosal Approach: A Cone Beam Computed Tomography Study","authors":"Haider Alramli, Robert Kelley, Stavros Sofos, Theofilos Koutouzis","doi":"10.1111/clr.70083","DOIUrl":"https://doi.org/10.1111/clr.70083","url":null,"abstract":"Objectives The aim was to compare buccal bone dimensional changes following implant placement with simultaneous guided bone regeneration (GBR), using either a submerged or transmucosal healing approach. Materials and Methods In this randomized, controlled clinical study, twenty‐eight patients with a single implant placed at a restorative‐driven position and with at least 2 mm of the coronal aspect of the implant exposed were allocated to be treated with GBR, either with a submerged healing approach (SBM Group) or a transmucosal healing approach (TSM Group). Cone beam computed tomography (CBCT) studies were taken immediately following treatment (T0) and at 4 months (T1). Vertical bone gain (VGAIN) was the primary outcome variable. Defect resolution, radiographic vertical defect height (RVDH), and radiographic bone thickness (RBT) were evaluated and compared. Results No significant differences were found between the groups for defect height resolution, VGAIN, RVDH, and RBT ( <jats:italic>p</jats:italic> &gt; 0.05). A significant reduction in RBT was found between T0 and T1 within the groups ( <jats:italic>p</jats:italic> &lt; 0.05). Conclusion The study found no significant differences in buccal bone dimensional changes between submerged and transmucosal healing approaches when implants were placed with simultaneous GBR.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"22 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145836135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Clinical Oral Implants Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1