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RETRACTION: Clinical and radiographic evaluation of osseotite-expanded platform implants related to crestal bone loss: a 10-year study 回放:与骨嵴骨质流失有关的骨质膨胀平台植入物的临床和放射学评估:一项为期 10 年的研究。
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-21 DOI: 10.1111/clr.14274

RETRACTION: J. L. Calvo-Guirado, G. Gómez-Moreno, R. A. Delgado-Ruiz, J. E. Maté Sánchez de Val, B. Negri, M. P. Ramírez Fernández, “Clinical and radiographic evaluation of osseotite-expanded platform implants related to crestal bone loss: a 10-year study”, Clinical Oral Implants Research 25, no. 3 (2014): 352–358, https://doi.org/10.1111/clr.12134.

The above article, published online on 21 February 2013 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Lisa J. A. Heitz-Mayfield; and John Wiley & Sons Ltd.

The retraction has been agreed due to concerns raised by third parties on the data presented in the article. Several flaws and inconsistencies between results presented and experimental methods described were found. Specifically, Figure 4a and Figure 4b are identical, while they should represent days 0 versus 10 years, respectively. Figure 4c and Figure 4d are identical, while they should represent days 0 versus 10 years, respectively. Additionally, there are instances of overlapping data with another publication authored by the same group. Accordingly, the editors consider the findings of this article unreliable and the conclusions to be invalid. The authors have been informed of the decision to retract the article. The corresponding author J. L. Calvo-Guirado and co-author R. A. Delgado-Ruiz disagree with the decision of retraction. The remaining co-authors were not available for a final confirmation of the retraction.

Retraction:J.L.Calvo-Guirado、G.Gómez-Moreno、R.A.Delgado-Ruiz、J.E.Maté Sánchez de Val、B.Negri、M.P.Ramírez Fernández,"与骨嵴骨质流失有关的骨质膨胀平台种植体的临床和放射学评估:一项为期 10 年的研究",《临床口腔种植体研究》第 25 期,第 3 号(2014 年):"与骨嵴骨质流失有关的骨质膨胀平台种植体的临床和放射学评估:一项为期 10 年的研究"。3 (2014):352-358, https://doi.org/10.1111/clr.12134.上述文章于 2013 年 2 月 21 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经期刊主编 Lisa J. A. Heitz-Mayfield 和 John Wiley & Sons Ltd.(约翰-威利父子有限公司)协商后已撤回。之所以同意撤稿,是因为第三方对文章中提供的数据提出了疑虑。我们发现文章所展示的结果与所描述的实验方法之间存在若干缺陷和不一致之处。具体来说,图 4a 和图 4b 完全相同,但它们应该分别代表 0 天和 10 年。图 4c 和图 4d 相同,但应分别代表 0 天和 10 年。此外,还有一些数据与同一小组撰写的另一份出版物重叠。因此,编辑认为这篇文章的研究结果不可靠,结论无效。已将撤稿决定通知作者。通讯作者 J. L. Calvo-Guirado 和合著者 R. A. Delgado-Ruiz 不同意撤稿决定。其余合著者无法对撤稿进行最终确认。
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引用次数: 0
RETRACTION: Crestal bone loss evaluation in osseotite expanded platform implants: a 5-year study 返回:骨壤扩展平台种植体的嵴状骨丢失评估:一项为期 5 年的研究。
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-21 DOI: 10.1111/clr.14280

RETRACTION: J. L. Calvo-Guirado, G. Gómez-Moreno, L. López-Marí, J. Guardia, B. Negri, J. M. Martínez-González, “Crestal bone loss evaluation in osseotite expanded platform implants: a 5-year study”, Clinical Oral Implants Research 22, no. 22 (2011): 1409–1414, https://doi.org/10.1111/j.1600-0501.2010.02130.x

The above article, published online on 21 March 2011 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal's Editor in Chief, Lisa J. A. Heitz-Mayfield; and John Wiley & Sons Ltd.

The retraction has been agreed due to concerns raised by third parties on the data presented in the article. Several flaws and inconsistencies between results presented and experimental methods described were found. Specifically, there are instances of overlapping data within the article and with another publication authored by the same group. Accordingly, the editors consider the findings of this article unreliable and the conclusions to be invalid. The authors have been informed of the decision to retract the article. The corresponding author J. L. Calvo-Guirado disagrees with the decision of retraction. The remaining co-authors were not available for a final confirmation of the retraction.

Retraction:J. L. Calvo-Guirado、G. Gómez-Moreno、L. López-Marí、J. Guardia、B. Negri、J. M. Martínez-González, "Crestal bone loss evaluation in osseotite expanded platform implants: a 5-year study", Clinical Oral Implants Research 22, no:1409-1414, https://doi.org/10.1111/j.1600-0501.2010.02130.x 上述文章于 2011 年 3 月 21 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经该杂志主编 Lisa J. A. Heitz-Mayfield 和 John Wiley & Sons Ltd. 协议撤回。同意撤稿的原因是第三方对文章中提供的数据表示担忧。我们发现文章中介绍的结果与实验方法之间存在若干缺陷和不一致之处。具体而言,文章中的数据与同一小组撰写的另一篇文章中的数据存在重叠。因此,编辑认为这篇文章的研究结果不可靠,结论无效。已将撤稿决定通知作者。通讯作者 J. L. Calvo-Guirado 不同意撤稿决定。其余共同作者无法对撤稿做出最终确认。
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引用次数: 0
RETRACTION: Histological and histomorphometric evaluation of immediate implant placement on a dog model with a new implant surface treatment 回放:采用新型种植体表面处理方法对狗模型即刻植入种植体进行组织学和组织形态计量学评估。
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-21 DOI: 10.1111/clr.14279

RETRACTION: J. L. Calvo-Guirado, A. J. Ortiz-Ruiz, B. Negri, L. López-Marí, C. Rodriguez-Barba, F. Schlottig, “Histological and histomorphometric evaluation of immediate implant placement on a dog model with a new implant surface treatment”, Clinical Oral Implants Research 21, no. 3 (2010): 308–315, https://doi.org/10.1111/j.1600-0501.2009.01841.x

The above article, published online on 9 February 2010 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal's Editor in Chief, Lisa J. A. Heitz-Mayfield; and John Wiley & Sons Ltd.

The retraction has been agreed due to concerns raised by third parties on the data presented in the article. Several flaws and inconsistencies between results presented and experimental methods described were found. Specifically, Figure 5b is described as control group, but it used in Figure 6b to represent the test group. Figure 7c is described as control group, but it used in Figure 8a to represent the test group. Accordingly, the editors consider the findings of this article unreliable and the conclusions to be invalid. The authors have been informed of the decision to retract the article. The corresponding author J. L. Calvo-Guirado disagrees with the decision of retraction. Co-authors A. J. Ortiz-Ruiz and F. Schlottig state that they were unaware of these issues and concur with the decision for retraction based on the presented findings. The remaining co-authors were not available for a final confirmation of the retraction.

Retraction:J.L.Calvo-Guirado、A.J.Ortiz-Ruiz、B.Negri、L.López-Marí、C.Rodriguez-Barba、F.Schlottig,"采用新型种植体表面处理方法在狗模型上即刻植入种植体的组织学和组织形态计量学评估",《临床口腔种植研究》21,no.3 (2010):308-315, https://doi.org/10.1111/j.1600-0501.2009.01841.x 上述文章于 2010 年 2 月 9 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经该杂志主编 Lisa J. A. Heitz-Mayfield 和 John Wiley & Sons Ltd. 协商,该文章已被撤回。同意撤稿的原因是第三方对文章中提供的数据表示担忧。我们发现文章中介绍的结果与实验方法之间存在若干缺陷和不一致之处。具体来说,图 5b 被描述为对照组,但在图 6b 中却用来代表测试组。图 7c 被描述为对照组,但在图 8a 中却用来代表试验组。因此,编辑认为本文的研究结果不可靠,结论无效。已将撤稿决定通知作者。通讯作者 J. L. Calvo-Guirado 不同意撤稿决定。共同作者A. J. Ortiz-Ruiz和F. Schlottig表示,他们不知道这些问题,并同意根据所提交的研究结果撤稿的决定。其余合著者无法对撤稿做出最终确认。
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引用次数: 0
Comparing the modified socket-shield technique with the conventional immediate implantation technique in the anterior dentition: A 5-year retrospective clinical study 在前牙中比较改良的窝沟封闭技术和传统的即刻种植技术:一项为期 5 年的回顾性临床研究。
IF 4.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-15 DOI: 10.1111/clr.14281
Xingfu Li, Xinhan Li, Yamei Xu, Gang Fu, Hong Huang

Aims

The aim of this retrospective clinical study was to compare the 5-year radiological and clinical outcomes of patients undergoing immediate implantation with or without the modified socket-shield technique.

Materials and Methods

Patients who underwent anterior tooth replacement via the modified socket-shield technique (MSST) or the conventional immediate implantation technique (CIIT) between 2016 and 2017 were included. The labial bone thickness was assessed at different measurement levels (0, 2, 4 and 6 mm apical to the implant shoulder (IS)) postoperatively (T1), 6 months postoperatively (T2) and 5 years postoperatively (T3). The pink aesthetic score (PES) was evaluated before surgery (T0) and at T2 and T3. Implant success, complications and patient satisfaction were evaluated at every visit.

Results

Thirty-six patients (18 in the MSST group) underwent follow-up for 5 years, with no cases of implant failure. Two cases of exposure were detected in the MSST group, but there were no significant effects on hard or soft tissue. Patients in the MSST group showed less and more stable bone resorption than did those in the CIIT group at any measurement level and any time. A higher PES was achieved in the MSST group. Patient satisfaction was similar in both groups.

Conclusions

The MSST is a reliable immediate implantation method because of its ability to preserve the alveolar bone and provide superior recovery of aesthetics.

目的:这项回顾性临床研究旨在比较采用或不采用改良窝沟封闭技术进行即刻种植的患者的5年放射学和临床结果:纳入2016年至2017年期间通过改良窝沟封闭技术(MSST)或传统即刻种植技术(CIIT)进行前牙替换的患者。分别在术后(T1)、术后 6 个月(T2)和术后 5 年(T3)的不同测量水平(种植肩(IS)根尖 0、2、4 和 6 毫米)评估唇侧骨厚度。术前(T0)、术后 6 个月(T2)和术后 5 年(T3)对粉色美学评分(PES)进行了评估。每次就诊都对种植成功率、并发症和患者满意度进行评估:36名患者(MSST组18名)接受了为期5年的随访,无一例种植失败。MSST 组有两例暴露,但对软硬组织没有明显影响。与 CIIT 组患者相比,MSST 组患者在任何时间、任何测量水平下的骨吸收都更少、更稳定。MSST 组的 PES 值更高。两组患者的满意度相似:MSST是一种可靠的即刻种植方法,因为它能够保留牙槽骨,并提供出色的美观恢复。
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引用次数: 0
Peri-implantitis and maxillary sinus membrane thickening: A retrospective cohort study 种植体周围炎与上颌窦膜增厚:回顾性队列研究
IF 4.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-15 DOI: 10.1111/clr.14282
Ramón Pons, Maria Giralt-Hernando, José Nart, Beatriz de Tapia, Federico Hernández-Alfaro, Alberto Monje

Objective

The objective of this study is to investigate the association of peri-implantitis (PI) and sinus membrane thickening and to assess the resolution of membrane thickening following intervention (implant removal or peri-implantitis treatment) aimed at arresting PI.

Materials and Methods

Forty-five patients with 61 implants in the posterior maxillary region were retrospectively included in the study. Twenty-four patients were diagnosed with peri-implantitis (PI) and 21 had peri-implant health (PH). Cone-beam computed tomography (CBCT) scans were evaluated to assess maxillary sinus characteristics, including membrane thickening, sinus occupancy and ostium patency. The CBCT scans taken 6 months after intervention aimed at arresting disease (implant removal or treatment of PI) in the PI group were also appraised and compared to baseline scans.

Results

At baseline, all parameters evaluating membrane thickness disorders yielded significant differences between groups (p < .001). Patients with posterior maxillary implants diagnosed with PI were 7× more likely to present membrane thickening compatible with pathology when compared to patients with healthy implants (OR = 7.14; p = .005). Furthermore, the likelihood was 6x greater in implants diagnosed with PI to exhibit moderate membrane thickening (OR = 6.75, p = .001). The patients receiving interventions aimed at arresting PI experienced significant enhancement in all radiographic parameters related to the sinus cavity at the 6-month follow-up (p < .001), though these variations were similarly independent of whether treatment consisted of PI treatment or implant removal.

Conclusions

Maxillary sinus membrane thickening and the permeability/obstruction of the ostium are frequently associated with the presence of PI in posterior implants. Interventions targeting disease resolution effectively reduce membrane thickness to levels compatible with maxillary sinus health.

研究目的本研究的目的是调查种植体周围炎(PI)与窦膜增厚之间的关系,并评估旨在阻止 PI 的干预措施(拔除种植体或治疗种植体周围炎)后窦膜增厚的缓解情况:本研究回顾性地纳入了 45 名在上颌后部植入 61 个种植体的患者。24名患者被诊断为种植体周围炎(PI),21名患者为种植体周围健康(PH)。对锥形束计算机断层扫描(CBCT)进行了评估,以评估上颌窦的特征,包括窦膜增厚、窦占位和窦口通畅。此外,还评估了PI组患者在采取旨在遏制疾病的干预措施(拔除种植体或治疗PI)6个月后的CBCT扫描结果,并与基线扫描结果进行了比较:结果:基线扫描时,所有评估膜厚度紊乱的参数在各组之间均存在显著差异(P上颌窦膜增厚和骨膜的通透性/阻塞经常与后牙种植体中存在 PI 有关。以解决疾病为目标的干预措施能有效地将膜厚度降低到与上颌窦健康相适应的水平。
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引用次数: 0
Additional Cover 附加封面
IF 4.3 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-08 DOI: 10.1111/clr.14284

The inside back cover image is based on the Original Article An in vitro analysis of the accuracy of static and robot-assisted implant surgery by Paul S. Mozer et al., https://doi.org/10.1111/clr.14233.

封底内页图片根据保罗-S-莫泽等人的原创文章《静态和机器人辅助植入手术的体外准确性分析》(An in vitro analysis of accuracy of static and robot-assisted implant surgery)制作,https://doi.org/10.1111/clr.14233。
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引用次数: 0
The distance of insertion points from wound margins in interrupted and vertical mattress sutures influences the tensile load capacity: An in vitro experimental study 间断缝合线和垂直褥式缝合线的插入点与伤口边缘的距离会影响拉伸负荷能力:体外实验研究
IF 4.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-22 DOI: 10.1111/clr.14273
Seungho Jeong, Won-Ho Lee, Kyu-Jin Hong, Franz Josef Strauss, Jung-Seok Lee

Aim

To determine the tensile load capacity (TLC) and the tearing characteristics for interrupted and vertical mattress sutures with different insertion points from the wound margin, and the effect of the bite size when using vertical mattress sutures.

Materials and Methods

A total of 120 gingiva and lining mucosa samples obtained from pig jaws were divided into groups according to the suturing technique (interrupted and vertical mattress sutures), distance of the insertion points from the wound margin (margin, 1, 3, and 5 mm) and bite size (1, 3, and 5 mm). The TLC of the suture and the tearing characteristics were evaluated using a tensile tester device.

Results

The TLC was significantly higher for vertical mattress sutures than for interrupted sutures regardless of the distance of the insertion points from the wound margin (intergroup p < .001). This distance significantly influenced the TLC for vertical mattress sutures (p < .05) but not for interrupted sutures (p > .05). Testing the tearing characteristics revealed that no tissue tearing occurred in groups when the insertion points were more than 3 mm from the wound margin.

Conclusion

The TLC is higher for vertical mattress sutures than for interrupted sutures, and it increases when the insertion points are farther from the wound margin.

材料和方法取自猪下颌的牙龈和衬垫粘膜样本共 120 份,根据缝合技术(间断缝合和垂直褥式缝合)、插入点距伤口边缘的距离(边缘、1、3 和 5 mm)以及咬合大小(1、3 和 5 mm)将其分为几组。结果无论插入点与伤口边缘的距离如何,垂直褥式缝合线的 TLC 都明显高于间断缝合线(组间 p <.001)。这一距离对垂直褥式缝合的 TLC 有明显影响(p <.05),但对间断缝合没有影响(p >.05)。结论 垂直褥式缝合线的 TLC 比间断缝合线高,而且当插入点距离伤口边缘较远时,TLC 会增加。
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引用次数: 0
Inter and intra-operator reliability of Lekholm and Zarb classification and proposal of a novel radiomic data-driven clustering for qualitative assessment of edentulous alveolar ridges Lekholm 和 Zarb 分级在操作员之间和操作员内部的可靠性,以及用于无牙槽嵴定性评估的新型放射学数据驱动聚类的建议
IF 4.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-17 DOI: 10.1111/clr.14271
Giuseppe Troiano, Antonio Rapani, Francesco Fanelli, Federico Berton, Marino Caroprese, Teresa Lombardi, Khrystyna Zhurakivska, Claudio Stacchi

Objectives

The present study was conducted to evaluate the reproducibility of Lekholm and Zarb classification system (L&Z) for bone quality assessment of edentulous alveolar ridges and to investigate the potential of a data-driven approach for bone quality classification.

Materials and Methods

Twenty-six expert clinicians were asked to classify 110 CBCT cross-sections according to L&Z classification (T0). The same evaluation was repeated after one month with the images put in a different order (T1). Intra- and inter-examiner agreement analyses were performed using Cohen's kappa coefficient (CK) and Fleiss' kappa coefficient (FK), respectively. Additionally, radiomic features extraction was performed from 3D edentulous ridge blocks derived from the same 110 CBCTs, and unsupervised clustering using 3 different clustering methods was used to identify patterns in the obtained data.

Results

Intra-examiner agreement between T0 and T1 was weak (CK 0.515). Inter-examiner agreement at both time points was minimal (FK at T0: 0.273; FK at T1: 0.243). The three different unsupervised clustering methods based on radiomic features aggregated the 110 CBCTs in three groups in the same way.

Conclusions

The results showed low agreement among clinicians when using L&Z classification, indicating that the system may not be as reliable as previously thought. The present study suggests the possible application of a reproducible data-driven approach based on radiomics for the classification of edentulous alveolar ridges, with potential implications for improving clinical outcomes. Further research is needed to determine the clinical significance of these findings and to develop more standardized and accurate methods for assessing bone quality of edentulous alveolar ridges.

本研究旨在评估 Lekholm 和 Zarb 分类系统(L&Z)用于无牙槽嵴骨质评估的可重复性,并研究数据驱动骨质分类方法的潜力。一个月后再次进行同样的评估,并将图像按不同顺序排列(T1)。分别使用科恩卡帕系数(CK)和弗莱斯卡帕系数(FK)对检查者内部和检查者之间的一致性进行分析。此外,还从来自相同的 110 张 CBCT 的三维无齿嵴块中提取了放射学特征,并使用 3 种不同的聚类方法进行无监督聚类,以确定所获数据中的模式。两个时间点的检查者之间的一致性很小(T0 的 FK:0.273;T1 的 FK:0.243)。基于放射学特征的三种不同的无监督聚类方法以相同的方式将 110 张 CBCT 分为三组。本研究表明,基于放射组学的可重复数据驱动方法可用于无牙槽嵴的分类,对改善临床结果具有潜在的意义。要确定这些研究结果的临床意义,并为评估无牙槽嵴骨质量开发更标准化、更准确的方法,还需要进一步的研究。
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引用次数: 0
Accuracy of template-based guided dental implant placement—An in vitro comparison of different manufacturing methods 基于模板引导的牙科植入物植入精度--不同制造方法的体外比较
IF 4.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-17 DOI: 10.1111/clr.14272
Aura Sium-Abel, Ludger Keilig, Istabrak Dörsam, Christoph Bourauel

Objectives

This study investigates effects of surgical guide manufacturing process on 3D transfer accuracy of planned dental implant position, using three production methods: additive 3D-printed (3DF), subtractive milled (MF), and analog laboratory fabricated templates (LF).

Material and Methods

Implant position for a single-tooth gap (#26) planned digitally. 3DF and MF templates were designed digitally, while LF templates were analogously created. For each manufacturing type, 10 surgical guides were fabricated. Each guide was used for template-guided implant placement in model replicas. For evaluation of implant placement, cone beam computed tomography scans of all implanted models were superimposed, and implant positions were determined. Deviations at implant shoulder/apex were measured, and median and inter-quartile range (IQR) were determined for mesio-distal, oro-facial, coronal apico, 3D spaces, and angles.

Results

At implant shoulder, vertical components dominated position deviations (up to 1.04 mm, IQR 0.28 mm for 3DF). Horizontal deviations were much lower (mesio-distally up to 0.38 mm, IQR 0.36 mm (LF)). Implant apex shows similar vertical deviations, while horizontal deviations clearly increased compared to shoulder, especially in mesio-distal direction. Median angular deviations were between 2.1° (IQR 2.0 mm, max. 4.2°) for 3DF and 3.3° (IQR 1.9 mm, max. 5.3°) for MF. No statistical differences were found between manufacturing types (Kruskal–Wallis test, p = .05).

Conclusions

The study showed the method of implant guide fabrication did not affect the accuracy of implant placement within the limits of an in vitro environment. All methods resulted in implant placement which did not exceed the accepted safety deviation envelope (1.5–2.0 mm).

材料和方法以数字方式规划单齿间隙(26 号)的种植体位置。3DF和MF模板采用数字化设计,LF模板采用模拟制作。每种制造类型都制作了 10 个手术导板。每个导板都用于在模板引导下在模型复制品中植入种植体。为评估植入位置,对所有植入模型进行锥形束计算机断层扫描,并确定植入位置。测量了种植体肩部/顶部的偏差,并确定了中远端、口面部、冠状面、三维空间和角度的中位数和四分位数间距(IQR)。结果在种植体肩部,垂直方向的偏差最大(达 1.04 毫米,3DF 的 IQR 为 0.28 毫米)。水平偏差要小得多(中轴偏差达 0.38 毫米,IQR 0.36 毫米(LF))。种植体顶点显示出相似的垂直偏差,而水平偏差与肩部相比明显增大,尤其是在中远端方向。3DF的中位角度偏差为2.1°(IQR为2.0 mm,最大为4.2°),MF的中位角度偏差为3.3°(IQR为1.9 mm,最大为5.3°)。研究结果表明,在体外环境下,种植导板的制作方法不会影响种植体植入的准确性。所有方法都能使种植体植入不超过公认的安全偏差范围(1.5-2.0 毫米)。
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引用次数: 0
Metabolic profiling of peri-implant crevicular fluid in peri-implantitis 种植体周围炎中种植体周围缝隙液的代谢谱分析
IF 4.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-16 DOI: 10.1111/clr.14270
Lu Song, Hongye Lu, Jimin Jiang, Antian Xu, Yanli Huang, Jia-Ping Huang, Pei-Hui Ding, Fuming He

Objects

This study aims to explore the etiology of peri-implantitis by comparing the metabolic profiles in peri-implant crevicular fluid (PICF) from patients with healthy implants (PH) and those with peri-implantitis (PI).

Materials and Methods

Fifty-six patients were enrolled in this cross-sectional study. PICF samples were collected and analyzed using both non-targeted and targeted metabolomics approaches. The relationship between metabolites and clinical indices including probing depth (PD), bleeding on probing (BOP), and marginal bone loss (MBL) was examined. Additionally, submucosal microbiota was collected and analyzed using 16S rRNA gene sequencing to elucidate the association between the metabolites and microbial communities.

Results

Significant differences in metabolic profiles were observed between the PH and PI groups, with 179 distinct metabolites identified. In the PI group, specific amino acids and fatty acids were significantly elevated compared to the PH group. Organic acids including succinic acid, fructose-6-phosphate, and glucose-6-phosphate were markedly higher in the PI group, showing positive correlations with mean PD, BOP, and MBL. Metabolites that increased in the PI group positively correlated with the presence of Porphyromonas and Treponema and negatively with Streptococcus and Haemophilus.

Conclusions

This study establishes a clear association between metabolic compositions and peri-implant condition, highlighting enhanced metabolite activity in peri-implantitis. These findings open avenues for further research into metabolic mechanisms of peri-implantitis and their potential therapeutic implications.

目的 本研究旨在通过比较健康种植体(PH)患者和种植体周围炎(PI)患者种植体周围缝隙液(PICF)中的代谢谱,探讨种植体周围炎的病因。采用非靶向和靶向代谢组学方法收集并分析了 PICF 样本。研究了代谢物与临床指标(包括探诊深度(PD)、探诊出血(BOP)和边缘骨质流失(MBL))之间的关系。此外,还收集了粘膜下微生物群,并使用 16S rRNA 基因测序法进行分析,以阐明代谢物与微生物群落之间的关系。结果PH 组和 PI 组之间的代谢谱存在显著差异,共发现 179 种不同的代谢物。与 PH 组相比,PI 组的特定氨基酸和脂肪酸明显升高。有机酸(包括琥珀酸、6-磷酸果糖和 6-磷酸葡萄糖)在 PI 组明显升高,与平均 PD、BOP 和 MBL 呈正相关。PI 组中增加的代谢物与卟啉单胞菌和特雷波纳菌的存在呈正相关,与链球菌和嗜血杆菌呈负相关。这些发现为进一步研究种植体周围炎的代谢机制及其潜在的治疗意义开辟了道路。
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引用次数: 0
期刊
Clinical Oral Implants Research
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