Clinical Oral Implants Research最新文献_第4页

Graftless Sinus Floor Elevation Using the Lateral or Transcrestal Approach. A Randomized Clinical Trial With One Year Follow-Up 采用外侧或经嵴入路的无移植物窦底抬高。一项随机临床试验，随访一年

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-10-10 DOI: 10.1111/clr.70055

Ahmed Ibrahim Aboul Fettouh, Noha Ayman Ghallab, Nael Adel, Rafik Nasser, Nourhan Gamal, Mariam Samy, Nesma Shemais

Introduction

This randomized clinical trial aimed to evaluate implant stability following graftless lateral window and crestal implant approaches for maxillary sinus floor elevation (MSFE) 1 year after implant placement.

Methods

Twenty-six single missing posterior maxillary teeth indicated for delayed implant placement, with a residual ridge height of 4–6 mm, were randomly assigned to perform either graftless lateral window (control) or crestal implant (test) approaches for MSFE. Implant stability was assessed using resonance frequency analysis; intra-sinus vertical bone gain and marginal bone loss were measured via CBCT 1 year after implant placement. Clinical parameters and patient-reported outcomes were also measured.

Results

The reported implant stability quotient (ISQ) values were not significantly different between the lateral window and the crestal implant approaches (80.92 ± 4.57 and 80.19 ± 7.28, respectively) 12 months after implant placement. However, the lateral window approach revealed a significant increase (p < 0.001) in the mean ± SD intra-sinus vertical bone gain at 6 and 12 months (3.64 ± 0.84 mm and 3.82 ± 0.84 mm, respectively) compared to the crestal implant approach (1.66 ± 1.27 mm and 2.42 ± 1.39 mm, respectively). However, no intergroup significant difference was noticed concerning average marginal bone loss (p = 0.31) after 12 months. Postoperative complications and patient discomfort were more evident in the lateral window approach group.

Conclusion

In patients with a residual ridge height of 4–6 mm receiving implant therapy in conjunction with maxillary sinus elevation without graft material, there was no statistically significant difference in implant stability at 12 months between a lateral window and transcrestal sinus approach. Greater vertical bone gain was achieved following the lateral window approach.

本随机临床试验旨在评估种植体植入后1年上颌窦底抬高（MSFE）无移植物侧窗和嵴种植入路后种植体的稳定性。方法选择26颗单颗缺失的上颌后牙（残牙脊高度为4-6 mm）进行延迟种植，随机分为无移植侧窗入路（对照）和牙冠种植入路（试验）两组。采用共振频率分析评估种植体稳定性；种植体放置1年后，通过CBCT测量窦内垂直骨增加和边缘骨损失。还测量了临床参数和患者报告的结果。结果种植体稳定性商数（ISQ）在侧窗入路和嵴入路12个月后差异无统计学意义（分别为80.92±4.57和80.19±7.28）。然而，侧窗入路在6个月和12个月的平均±SD窦内垂直骨增重（分别为3.64±0.84 mm和3.82±0.84 mm）比嵴种植入路（分别为1.66±1.27 mm和2.42±1.39 mm）显著增加（p < 0.001）。然而，12个月后，两组间在平均边缘骨质流失方面无显著差异（p = 0.31）。侧窗入路组术后并发症和患者不适更为明显。结论在残脊高度为4 ~ 6 mm的患者中，采用侧窗入路与经瓣入路的种植体稳定性在12个月时无统计学差异。侧窗入路可获得更大的垂直骨增重。

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引用次数: 0

Pre-Surgical Risk Assessment for Sinus Membrane Perforation: A Retrospective Cohort Study 窦膜穿孔的术前风险评估：一项回顾性队列研究。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-10-08 DOI: 10.1111/clr.70054

Shale Ninneman, Shing-Zeng Dung, Tiziano Testori, Diane M. Daubert, I-Chung Wang, Nelly Badr, Yung-Ting Hsu

Aim

This study aims to validate an existing risk assessment (RA) tool for predicting sinus membrane perforation (SMP) during the lateral-window sinus floor elevation (LSFE).

Materials and Methods

A multiple-center study was conducted in a hospital and university setting. Cone-beam computed tomography (CBCT) images and health records of patients who received LSFE from 2005 to 2021 were assessed. The effectiveness of the RA tool was evaluated on our dataset and additional analyses were performed to identify the key risk factors using logistic regression and the classification and regression trees (CART) methods.

Results

A total of 126 sinuses in 113 patients were assessed, including 49 females and 64 males (60.1 ± 11.65 y/o). There were 24 SMP events in the study population. Patient-level and sinus-level analyses were consistent. The reduced logistic regression model suggested that the odds ratio (OR) of having an SMP event decreases by 23.7% with a 1 mm increase in residual bone height (RBH). Using a 3-mm RBH as the cut-off between “low risk” and “high risk,” rather than 4 mm as suggested in the original RA tool, provided better separation of SMP rates. CART analysis revealed that age may also be related to SMP risk.

Conclusion

In this exploratory study, RBH was the factor most correlated with SMP risk during LSFE, followed by age at the time of surgery. The critical thresholds for predicting SMP events were identified as 3.02 mm for RBH and 55.5 years of age. Within the inherent limitations, the current risk assessment tool could not be fully validated.

目的：本研究旨在验证现有的风险评估（RA）工具在侧窗窦底抬高（LSFE）期间预测窦膜穿孔（SMP）。材料与方法在医院和大学进行了一项多中心研究。评估了2005年至2021年接受LSFE治疗的患者的锥束计算机断层扫描（CBCT）图像和健康记录。在我们的数据集上评估了RA工具的有效性，并使用逻辑回归和分类回归树（CART）方法进行了额外的分析，以确定关键风险因素。结果113例患者共126个鼻窦，其中女性49例，男性64例（60.1±11.65 y/o）。在研究人群中有24例SMP事件。患者水平和窦水平的分析是一致的。简化logistic回归模型显示，残骨高度（RBH）每增加1 mm，发生SMP事件的比值比（OR）降低23.7%。使用3毫米的RBH作为“低风险”和“高风险”之间的分界点，而不是原始RA工具中建议的4毫米，可以更好地分离SMP发生率。CART分析显示，年龄也可能与SMP风险有关。结论在这项探索性研究中，RBH是与LSFE中SMP风险最相关的因素，其次是手术时的年龄。预测SMP事件的临界阈值被确定为RBH和55.5岁的3.02 mm。由于固有的局限性，目前的风险评估工具无法得到充分的验证。

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引用次数: 0

Impact of Marginal Misfit in Implant-Supported Fixed Dental Prostheses on Peri-Implant Bone Levels: A Retrospective Quantitative Analysis 种植体支持的固定义齿边缘错位对种植体周围骨水平的影响：回顾性定量分析

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-10-04 DOI: 10.1111/clr.70053

Emilio Couso-Queiruga, Christoph A. Ramseier, Vivianne Chappuis, Simone F. M. Janner M, Daniel Buser, Urs Brägger, Giovanni E. Salvi

Objectives

To evaluate the impact of the marginal fit of implant-supported prostheses (ISP) on peri-implant bone levels. Additionally, the study aimed to determine a clinically relevant threshold for the radiographic vertical misfit gap at the ISP, when present, and to identify potential risk factors associated with changes in bone levels.

Methods

This study involved subjects who received ISPs for tooth replacement therapy. Standardized intraoral periapical radiographs were taken 10 years after loading to assess the radiographic distance between the implant shoulder and the most coronal point of crestal bone (DIB). ISP marginal gaps were categorized as no gap or gap, with vertical dimensions categorized as 0 mm, > 0- < 0.1 mm, and ≥ 0.1 mm. A multivariable linear mixed-effect model was applied to control for potential confounders.

Results

A total of 301 patients and 505 implants with a 10.6 ± 0.7 years follow-up were analyzed. ISPs without gaps exhibited statistically significantly lower DIB values (3.22 ± 0.8 mm) than those with gaps (3.43 ± 0.6 mm; p = 0.001). Gaps ≥ 0.1 mm were associated with statistically significantly higher DIB values (3.45 ± 0.7 mm; p = 0.001) compared with gaps between > 0 and < 0.1 mm (3.36 ± 0.5 mm; p = 0.001), or no gaps (3.22 ± 0.7 mm; p = 0.001). Each increment of 0.1 mm in the vertical crestal gap corresponded to a significant increase in DIB values (0.08 mm; p = 0.03). Finally, smoking and a history of periodontitis were independent risk factors for increased DIB.

Conclusions

Marginal misfit of ISP affects peri-implant bone stability, with gaps ≥ 0.1 mm linked to higher DIB. Smoking and periodontitis are independent risk factors for increased DIB.

目的评价种植体支撑假体（ISP）的边缘配合度对种植体周围骨水平的影响。此外，该研究的目的是确定一个临床上相关的阈值，当ISP存在放射学垂直不匹配间隙时，并确定与骨水平变化相关的潜在危险因素。方法本研究纳入了接受isp牙齿替代治疗的受试者。装填10年后，采用标准化的口内根尖周x线片评估植入体肩关节与冠状骨（DIB）最冠状点之间的x线距离。ISP边际间隙分为无间隙和间隙，垂直尺寸分为0 mm、0 ~ 0.1 mm和≥0.1 mm。采用多变量线性混合效应模型控制潜在混杂因素。结果共分析301例患者和505颗种植体，随访10.6±0.7年。无间隙isp的DIB值（3.22±0.8 mm）显著低于有间隙isp的DIB值（3.43±0.6 mm, p = 0.001）。与>； 0和<； 0.1 mm的间隙（3.36±0.5 mm, p = 0.001）或无间隙（3.22±0.7 mm, p = 0.001）相比，间隙≥0.1 mm的DIB值（3.45±0.7 mm, p = 0.001）有统计学意义显著升高。垂直峰隙每增加0.1 mm， DIB值显著增加（0.08 mm, p = 0.03）。最后，吸烟和牙周炎史是DIB增加的独立危险因素。结论ISP的轻微错位影响种植体周围的骨稳定性，间隙≥0.1 mm与较高的DIB相关。吸烟和牙周炎是DIB增加的独立危险因素。

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引用次数: 0

Ten-Year Results of a Prospective Study on One-Piece Zirconia Oral Implants for Single-Tooth Reconstruction 一体式氧化锆口腔种植体用于单牙重建的十年前瞻性研究结果。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-10-02 DOI: 10.1111/clr.70049

Ralf-Joachim Kohal, Agneta Lith, Futoshi Komine, Junichi Honda, Benedikt C. Spies, Felix Burkhardt, Kirstin Vach

Objectives

The intention of this 10-year prospective cohort investigation was to clinically and radiographically investigate the outcomes of a one-piece zirconia implant system for single-tooth replacement.

Materials and Methods

A total of 65 patients received 66 single-tooth implants restored with all-ceramic crowns. Follow-up assessments were conducted at the time of prosthetic delivery, after 1, 3, 5, and 10 years. Peri-implant soft tissue parameters were evaluated. To assess peri-implant bone loss, standardized radiographs were taken at implant placement, prosthetic delivery, at the 1-, 3-, 5-, and 10-year follow-ups. Statistical analysis was conducted using linear mixed regression models and Wilcoxon Signed Rank tests to compare differences over time and between groups (p < 0.05).

Results

Over the course of 10 years, 16 implants were lost, yielding a cumulative survival rate of 73.3%. Fifteen patients were lost to follow-up over the 10-year period. The average marginal bone loss of the remaining implants was 1.09 mm. Probing depth, attachment level, and bleeding showed an increase over time, while plaque index slightly decreased.

Conclusions

Given the high implant loss rate after 10 years and the high occurrence of advanced bone loss observed in this study, the implant was not recommended for routine clinical use.

目的：这项为期10年的前瞻性队列研究的目的是临床和影像学研究用于单牙置换的一体式氧化锆种植体系统的结果。材料与方法65例患者行全瓷冠单牙种植体修复66例。随访评估分别在假肢交付时、1年、3年、5年和10年后进行。评估种植体周围软组织参数。为了评估种植体周围骨丢失，在种植体放置、假体运送、1年、3年、5年和10年随访时拍摄标准化x线片。采用线性混合回归模型和Wilcoxon sign Rank检验进行统计学分析，比较时间和组间差异（p < 0.05）。结果在10年的时间里，16个种植体丢失，累计存活率为73.3%。在10年的时间里，有15名患者失去了随访。剩余种植体的平均边缘骨损失为1.09 mm。探针深度、附着水平和出血随时间增加，而斑块指数略有下降。结论考虑到本研究中观察到的10年后种植体的高损失率和晚期骨质流失的高发生率，不建议常规临床使用该种植体。

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引用次数: 0

Long-Term Performance of Bi-Layered Single Crowns Supported by Zirconia Implants: 7.5-Year Results of a Two-Center Prospective Cohort Study 氧化锆种植体支持双层单冠的长期性能：一项为期7.5年的双中心前瞻性队列研究结果。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-26 DOI: 10.1111/clr.70051

Marc Balmer, Benedikt C. Spies, Margherita G. Liguori, Kirstin Vach, Ronald E. Jung, Ralf-Joachim Kohal

Objective

To evaluate the survival and success rates of veneered zirconia-based single crowns (SCs) supported by zirconia implants in posterior regions, along with patient-reported outcomes, over 7.5 years.

Materials and Methods

Forty-five patients received zirconia implant-supported posterior SCs (n = 45) composed of zirconia frameworks layered with a leucite-reinforced feldspathic ceramic. At 7.5 years, clinical parameters and technical complications were assessed. Technical success was determined according to modified United States Public Health Service (USPHS) criteria. Patient-reported outcome measures (PROs) were evaluated using visual analog scales (VAS). Wilcoxon matched-pairs signed-rank test, mixed-effects ordered logistic regression, and linear mixed models analyzed time-dependent effects.

Results

Thirty SCs (n = 30) could be evaluated at the 7.5-year follow-up (mean: 92.1 ± 3.4 months). Kaplan–Meier survival for SCs was 97.5% [95% CI: 83.6%–99.6%]. Success dropped to 79.4% [63.0%–89.2%] due to reconstructions with major chipping (n = 3), occlusal roughness (n = 7), marginal crevice (n = 1), and over-contouring (n = 2). PROs showed significant improvements from pre-treatment to delivery (VAS scores: 93%–97%) and remained stable throughout the follow-up period.

Conclusion

Veneered zirconia-based SCs supported by zirconia implants in posterior sites demonstrated high survival rates and consistently met patients' functional and esthetic expectations. Despite these favorable outcomes, the considerable incidence of technical complications warrants further investigation through long-term clinical studies.

Clinical Significance

While veneered zirconia crowns offer favorable esthetics, their susceptibility to chipping in posterior regions suggests that monolithic alternatives may be preferable. Further research is needed to optimize material selection and minimize technical complications.

目的评估后牙区氧化锆种植体支持的氧化锆单冠（SCs）在7.5年以上的生存率和成功率，以及患者报告的结果。材料与方法45例患者接受了由氧化锆框架与白晶石增强长石陶瓷层合而成的氧化锆支撑的后路sc （n = 45）。7.5岁时，评估临床参数和技术并发症。技术成功与否是根据修改后的美国公共卫生局（USPHS）标准确定的。采用视觉模拟量表（VAS）评估患者报告的预后指标（PROs）。Wilcoxon配对对符号秩检验、混合效应有序逻辑回归和线性混合模型分析了随时间变化的效应。结果随访7.5年（平均：92.1±3.4个月），共获得30例SCs。SCs的Kaplan-Meier存活率为97.5% [95% CI: 83.6%-99.6%]。由于主要切屑（n = 3）、咬合粗糙（n = 7）、边缘缝隙（n = 1）和过度轮廓（n = 2）的重建，成功率下降到79.4%[63.0%-89.2%]。从治疗前到分娩，PROs表现出显著的改善（VAS评分：93%-97%），并在整个随访期间保持稳定。结论氧化锆种植体支持的氧化锆贴面干细胞具有较高的存活率，并始终满足患者的功能和美学期望。尽管这些良好的结果，相当大的技术并发症的发生率值得通过长期的临床研究进一步调查。临床意义虽然贴面氧化锆冠具有良好的美观性，但其后牙区易碎裂，提示整体替代可能更可取。需要进一步的研究来优化材料选择和减少技术复杂性。

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引用次数: 0

Zirconia Minimizes Myeloid Innate Immunity as Dental Implants: An In Silico and In Vivo Study 氧化锆作为牙种植体最大限度地减少髓系先天免疫：一项在硅和体内的研究。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-25 DOI: 10.1111/clr.70037

Li-Tzu Wang, Hsuan-Hao Chang, Yi-Ting Liao, Wei-An Chen, Yu-Wen Huang, Yi-Wen Chen

Aim

While titanium has traditionally been the industry standard, zirconia presents superior physical and chemical properties that merit further investigation into its clinical efficacy. This study aims to examine the immunological responses associated with zirconia and titanium dental implants, emphasizing the potential advantages of zirconia as a viable alternative.

Materials and Methods

This study compares the immune responses to titanium and zirconia implants using a murine model, in which two implants were placed in the maxillary edentulous region for 7 days. Following this period, peri-implant tissue was harvested from 9 and 45 mice to assess myeloid immunity at both the transcriptomic and cellular levels, respectively.

Results

Our findings indicate that zirconia implants exhibit superior biocompatibility compared to titanium implants, evidenced by transcriptomic data showing a minimal myeloid cell-mediated inflammatory response. Specifically, zirconia implants significantly reduce the infiltration and attachment of myeloid cells, particularly polymorphonuclear neutrophils. Additionally, zirconia implants prevent the polarization of macrophages to the inflammatory M1 phenotype, which is markedly heightened in titanium peri-implant tissues, promoting instead a shift toward the regenerative M2 phenotype.

Conclusions

These results suggest that zirconia implants can minimize inflammation and promote better healing. This experimental in vivo study provides evidence that zirconia implants offer a more biocompatible solution in the field of dental restoration compared to titanium.

虽然钛传统上是行业标准，但氧化锆具有优越的物理和化学性能，值得进一步研究其临床疗效。本研究旨在研究氧化锆和钛种植体的免疫反应，强调氧化锆作为一种可行的替代方案的潜在优势。材料与方法本研究采用小鼠模型，在上颌无牙区放置两种钛和氧化锆种植体7天，比较两种种植体的免疫反应。在这段时间之后，分别从9只和45只小鼠身上采集种植体周围组织，在转录组学和细胞水平上评估骨髓免疫。结果我们的研究结果表明，与钛种植体相比，氧化锆种植体具有更好的生物相容性，转录组学数据显示骨髓细胞介导的炎症反应最小。具体来说，氧化锆植入物显著减少骨髓细胞的浸润和附着，特别是多形核中性粒细胞。此外，氧化锆植入物阻止巨噬细胞向炎性M1表型的极化，这在钛种植体周围组织中显著增强，从而促进巨噬细胞向再生M2表型的转变。结论氧化锆种植体可以减少炎症，促进愈合。本实验体内研究证明，与钛相比，氧化锆种植体在牙齿修复领域提供了更好的生物相容性解决方案。

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引用次数: 0

Cross-Linked Volume-Stable Collagen Matrix Versus Connective Tissue Graft for Soft Tissue Augmentation at Implant Site. A Non-Inferiority, Multicenter Randomized Clinical Trial 交联体积稳定的胶原基质与结缔组织移植物在种植体部位的软组织增强。一项非劣效性、多中心随机临床试验

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-22 DOI: 10.1111/clr.70050

Francesco Cairo, Cosimo Rupe, Raffaele Cavalcanti, Luca Landi, Antonio Rupe, Nicola Marco Sforza, Walter Castelluzzo, Maria Di Martino, Luigi Barbato

Aims

To compare the efficacy of cross-linked volume-stable collagen matrix (VCMX) versus connective tissue graft (CTG) to increase buccal peri-implant mucosal thickness (MT) around dental implants.

Methods

The present is a parallel, randomized multi-center clinical trial, according to the CONSORT statement. Clinical centers were four Italian periodontal settings. All patients received a soft tissue augmentation procedure, by means of CTG or VCMX. The primary outcome variable was peri-implant mucosal thickness (MT) difference at 12 months follow-up. The statistical unit was the patient. An analysis of covariance was performed for this outcome variable. Secondary outcomes were patient-reported outcome measures (PROMs), complications, variability among operators, and changes in keratinized mucosa width (KMW).

Results

A total of 98 patients completed the study, 49 in each group. MT increase was 1.0 ± 0.75 in the CTG group and 0.66 ± 0.58 mm in the VCMX group. CTG showed superior results to VCMX for MT gain (0.37 mm, 95% CI: 0.13–0.61, p = 0.002). In cases of Baseline MT ≥ 2 mm, CTG and VCMX yielded comparable results. VCMX was associated with shorter chair time (diff: 10.0 min; 95% CI: 5.02 to 14.98; p < 0.0001). Patients in the VCMX group experienced fewer days of discomfort (0.46 days, 95% CI: 0.06–0.99, p = 0.05), while no differences were found for final aesthetic and general satisfaction (CTG: 99.28 ± 2.28, VCMX: 98.48 ± 3.92, p = 0.22).

Conclusions

Both techniques improved MT, and CTG yielded better outcomes. VCMX was associated with shorter chair time and less postoperative discomfort, but both procedures achieved excellent final patient satisfaction.

目的比较交联体积稳定型胶原基质（VCMX）与结缔组织移植物（CTG）在增加种植体周围口腔黏膜厚度（MT）方面的效果。方法：根据CONSORT声明，本研究是一项平行、随机的多中心临床试验。临床中心是四个意大利牙周设置。所有患者均通过CTG或VCMX接受软组织增强手术。主要结局变量为12个月随访时种植体周围粘膜厚度（MT）差异。统计单位是病人。对该结果变量进行协方差分析。次要结果是患者报告的结果测量值（PROMs）、并发症、操作人员之间的差异和角化粘膜宽度（KMW）的变化。结果共98例患者完成研究，每组49例。CTG组MT增加1.0±0.75 mm， VCMX组MT增加0.66±0.58 mm。CTG在MT增益方面优于VCMX （0.37 mm, 95% CI: 0.13-0.61, p = 0.002）。在基线MT≥2mm的情况下，CTG和VCMX的结果相当。VCMX与较短的坐椅时间相关（差异：10.0 min; 95% CI: 5.02至14.98;p < 0.0001）。VCMX组患者的不适天数较少（0.46天，95% CI: 0.06-0.99, p = 0.05），而最终美学和总体满意度无差异（CTG: 99.28±2.28,VCMX: 98.48±3.92,p = 0.22）。结论两种技术均能改善MT， CTG治疗效果更好。VCMX与更短的坐椅时间和更少的术后不适相关，但两种手术都获得了极好的最终患者满意度。

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引用次数: 0

Does Calcium Phosphate Peri-Implant Grafting Improve Osseointegration of Dental Implants? An Experimental In Vivo Study 磷酸钙种植体周围移植能改善种植体的骨整合吗？一项实验性体内研究。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-16 DOI: 10.1111/clr.70046

F. C. A. Lima, S. De Moraes, S. C. Sartoretto, P. S. Nunes, C. M. S. F. dos Santos, B. Ghiraldini, F. J. B. Bezerra, J. M. Granjeiro, M. D. Calasans-Maia, R. S. Louro

Objective

This in vivo study aimed to evaluate the osseointegration of dental implants with a nanostructured hydroxyapatite (HAnano) coating or a double acid-etched (DAA) surface, grafted with or without calcium phosphate in the peri-implant gap, in low-density bone in a sheep model.

Materials and Methods

Thirty implants (15 HAnano and 15 DAA) were installed in the iliac crest of five sheep (2–4 years old). Six implants were placed per animal: two with a xenograft biomaterial, two with an alloplastic biomaterial, and two without grafting (control). Microtomographic analyses evaluated the percentage of bone and biomaterial for all groups. Histomorphometric analysis assessed bone-implant contact (BIC), bone occupied area fraction (BAFo), and biomaterial presence after an 8-week healing period. Data were analyzed using repeated-measures ANOVA or mixed-effects models with a significance level of 0.05.

Results

No complications were observed during the healing period. The average BIC across all groups was 55%, ranging from 4.6% to 67.7%. BAFo averaged 30%, with biomaterial occupying 22% and connective tissue 44% of the interface area. There were no statistically significant differences between grafted and non-grafted groups for BIC (p = 0.413), BAFo (p = 0.097), connective tissue presence (p = 0.192), and for the percentage of bone and biomaterial (p = 0.959), bone percentage (p = 0.283), or biomaterial percentage (p > 0.0959).

Conclusion

Peri-implant grafting with xenograft or alloplastic biomaterials did not significantly enhance osseointegration compared to ungrafted implants in small peri-implant defects. These results suggest that spontaneous healing may suffice in such cases.

目的：本体内研究旨在评估纳米结构羟基磷灰石（HAnano）涂层或双酸蚀（DAA）表面的牙种植体在低密度骨羊模型中的骨整合，在种植体周围间隙中植入或不植入磷酸钙。材料与方法将30个假体（HAnano 15个，DAA 15个）植入5只2-4岁绵羊的髂骨。每只动物放置6个植入物：2个采用异种移植生物材料，2个采用同种异体生物材料，2个不采用移植（对照组）。显微层析分析评估了所有组的骨和生物材料的百分比。组织形态计量学分析评估骨-种植体接触（BIC）、骨占据面积分数（BAFo）和8周愈合期后生物材料的存在。数据分析采用重复测量方差分析或混合效应模型，显著性水平为0.05。结果愈合期间无并发症发生。所有小组的平均BIC为55%，范围从4.6%到67.7%不等。BAFo平均占30%，生物材料占22%，结缔组织占44%。移植物组与非移植物组在BIC （p = 0.413）、BAFo （p = 0.097）、结缔组织存在（p = 0.192）以及骨和生物材料百分比（p = 0.959）、骨百分比（p = 0.283）或生物材料百分比（p > 0.0959）方面差异均无统计学意义。结论同种异体或同种异体生物材料在种植体周围小缺损中的骨整合效果不明显。这些结果表明，在这种情况下，自发愈合可能就足够了。

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引用次数: 0

Oral Communication 第32届欧洲骨整合协会年度科学会议2025年9月18日至20日。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-15 DOI: 10.1111/clr.70008

引用次数: 0

ePoster 第32届欧洲骨整合协会年度科学会议2025年9月18日至20日。

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2025-09-15 DOI: 10.1111/clr.70007

引用次数: 0