Clinical Oral Implants Research最新文献_第6页

Clinical, radiographic and patient-reported outcomes of zirconia and titanium implants in the posterior zone after 1 year of loading—A randomized controlled trial 后区氧化锆和钛种植体植入 1 年后的临床、影像学和患者报告结果--随机对照试验。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-07-26 DOI: 10.1111/clr.14329

Anina N. Zuercher, Marc Balmer, Lily V. Brügger, Daniel S. Thoma, Ronald E. Jung, Stefan P. Bienz

Objective

To assess the clinical, radiographic and patient-reported outcomes (PROMs) of posterior zirconia and titanium implants at 1 year of implant loading.

Materials and Methods

Forty-two patients with two adjacent missing teeth were enrolled in a randomized controlled trial with a within-subject controlled design. Each patient received one zirconia (Zr) and one titanium (Ti) implant, with the mesial and distal positions randomized. The implant restoration consisted of multiple layered zirconia, with the buccal aspect veneered. In group Zr, the restoration was intraorally cemented onto the one-piece Zr implant, whereas in group Ti, the restoration was extraorally cemented onto the titanium base abutment and intraorally screw-retained onto the Ti implant. Examinations were performed following restoration delivery at baseline (BL) and at 1 year. Measurements included clinical parameters, radiographic outcomes (MBL) and PROMs.

Results

Bleeding on probing showed an increase from BL to 1 year (34 ± 30% for Zr; 25 ± 21% for Ti). MBL remained stable with minimal changes from BL to 1 year, measuring 0.1 ± 0.4 mm (mean ± SD) for Zr and −0.1 ± 0.7 mm for Ti. Veneering fractures were the most frequent technical complication and amounted to 17.5% in group Zr and 5% in group Ti (p = .100). Patients preferred Zr implants for their soft tissue color, with a significant difference in perception between patients and clinicians (p < .017).

Conclusion

The study showed that both Zr and Ti implants had similar clinical outcomes, despite a high prevalence of mucositis and a few technical complications. Both implant types demonstrated stable marginal bone levels and similar patient-reported outcome measures.

目的评估后部氧化锆和钛种植体在植入一年后的临床、影像学和患者报告结果（PROMs）：42 名有两颗相邻缺失牙的患者参加了一项随机对照试验，试验采用受试者内对照设计。每位患者都接受了一颗氧化锆（Zr）和一颗钛（Ti）种植体，中远端位置随机。种植体修复体由多层氧化锆组成，颊侧贴面。在 Zr 组中，修复体在口腔内与一体式 Zr 种植体固位，而在 Ti 组中，修复体在口腔外与钛基台固位，在口腔内与 Ti 种植体用螺丝固位。修复体交付后，分别在基线（BL）和一年后进行检查。测量包括临床参数、放射学结果（MBL）和PROMs：结果：从基线到 1 年期间，探诊出血量有所增加（锆为 34 ± 30%；钛为 25 ± 21%）。MBL保持稳定，从BL到1年的变化很小，Zr为0.1 ± 0.4 mm（平均值± SD），Ti为-0.1 ± 0.7 mm。贴面骨折是最常见的技术并发症，Zr 组为 17.5%，Ti 组为 5%（p = .100）。患者更喜欢 Zr 种植体的软组织颜色，但患者和临床医生的看法存在显著差异（p 结论：Zr 和 Ti 种植体的软组织颜色都比 Zr 种植体好：研究表明，尽管粘膜炎的发病率较高且存在一些技术并发症，但锆和钛种植体的临床效果相似。两种类型的种植体都表现出稳定的边缘骨水平和相似的患者报告结果。

{"title":"Clinical, radiographic and patient-reported outcomes of zirconia and titanium implants in the posterior zone after 1 year of loading—A randomized controlled trial","authors":"Anina N. Zuercher, Marc Balmer, Lily V. Brügger, Daniel S. Thoma, Ronald E. Jung, Stefan P. Bienz","doi":"10.1111/clr.14329","DOIUrl":"10.1111/clr.14329","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the clinical, radiographic and patient-reported outcomes (PROMs) of posterior zirconia and titanium implants at 1 year of implant loading.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Forty-two patients with two adjacent missing teeth were enrolled in a randomized controlled trial with a within-subject controlled design. Each patient received one zirconia (Zr) and one titanium (Ti) implant, with the mesial and distal positions randomized. The implant restoration consisted of multiple layered zirconia, with the buccal aspect veneered. In group Zr, the restoration was intraorally cemented onto the one-piece Zr implant, whereas in group Ti, the restoration was extraorally cemented onto the titanium base abutment and intraorally screw-retained onto the Ti implant. Examinations were performed following restoration delivery at baseline (BL) and at 1 year. Measurements included clinical parameters, radiographic outcomes (MBL) and PROMs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Bleeding on probing showed an increase from BL to 1 year (34 ± 30% for Zr; 25 ± 21% for Ti). MBL remained stable with minimal changes from BL to 1 year, measuring 0.1 ± 0.4 mm (mean ± SD) for Zr and −0.1 ± 0.7 mm for Ti. Veneering fractures were the most frequent technical complication and amounted to 17.5% in group Zr and 5% in group Ti (<i>p</i> = .100). Patients preferred Zr implants for their soft tissue color, with a significant difference in perception between patients and clinicians (<i>p</i> < .017).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study showed that both Zr and Ti implants had similar clinical outcomes, despite a high prevalence of mucositis and a few technical complications. Both implant types demonstrated stable marginal bone levels and similar patient-reported outcome measures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 11","pages":"1428-1439"},"PeriodicalIF":4.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-sectional CBCT assessment of the relative position of one-piece titanium-zirconium mini-implants placed for mandibular overdentures using non-guided surgery 使用非引导手术对下颌覆盖义齿植入的一体式钛锆迷你植入体的相对位置进行横截面 CBCT 评估。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-07-23 DOI: 10.1111/clr.14335

Cláudio Rodrigues Leles, Leuçon de Oliveira Moura-Neto, Jésio Rodrigues Silva, Lays Noleto Nascimento, Thalita Fernandes Fleury Curado, Nadia Lago Costa, Martin Schimmel, Gerald McKenna

Objective

To assess the relative position of mini-implants to retain a mandibular overdenture, according to the surgical protocol, technical and anatomical factors.

Methods

Mandibular cone-beam computed tomography (CBCT) scans were analyzed for 73 patients who received four one-piece titanium-zirconium mini-implants. Drilling was performed using a 1.6 mm needle drill and a 2.2 mm Pilot Drill, according to the bone density with a surgical stent. Post-insertion CBCT images in DICOM format were analyzed using the E-Vol-DX software with BAR filters. Divergence angle between implants and between implants and the overdenture path of insertion was measured using CliniView 10.2.6 software.

Results

Divergence between implants ranged from 0° to 22.3° (mean = 4.2; SD = 3.7) in the lateral and from 0° to 26.2° (mean = 5.3; SD = 4.1) in the frontal projections (p < .001). Only 1 (0.2%) and 3 (0.7%) of the measurements were higher than 20° in the lateral and frontal views, respectively. The mean angulations between the implant and the path of insertion for the overdenture were 9.3° (SD = 7.5) and 4.0° (SD = 2.9) for the lateral and frontal views, respectively (p < .001). Regression analyses showed a significant association between the divergence of implants and the frontal view projection (p < .001), greater distance between the paired implants (p = .017), the flapped surgical protocol (p = .002), higher final insertion torque (p = .011), and deeper preparation with the needle drill (p < .001).

Conclusions

The mini-implants were placed with low divergence angles and satisfactory parallelism. Factors including shorter distances between the implants, higher density bone, and a flapless surgical approach all contributed positively to improved parallelism of the mini-implants.

目的根据手术方案、技术和解剖因素，评估微型种植体保留下颌覆盖义齿的相对位置：对 73 名接受了四颗一体式钛锆迷你种植体的患者的下颌锥形束计算机断层扫描（CBCT）进行分析。根据骨密度使用 1.6 毫米针钻和 2.2 毫米先导钻进行钻孔，并使用手术支架。使用带有 BAR 过滤器的 E-Vol-DX 软件对 DICOM 格式的植入后 CBCT 图像进行了分析。使用 CliniView 10.2.6 软件测量了种植体之间以及种植体与覆盖义齿插入路径之间的发散角：结果：种植体之间的偏离角度在侧面投影中为 0°至 22.3°（平均值 = 4.2；标度 = 3.7），在正面投影中为 0°至 26.2°（平均值 = 5.3；标度 = 4.1）（P 结论：种植体之间的偏离角度在侧面投影中为 0°至 22.3°（平均值 = 4.2；标度 = 3.7），在正面投影中为 0°至 26.2°（平均值 = 5.3；标度 = 4.1）：微型种植体植入后的发散角小，平行度令人满意。种植体之间的距离较短、骨密度较高以及无瓣手术方法等因素都有助于改善微型种植体的平行度。

{"title":"A cross-sectional CBCT assessment of the relative position of one-piece titanium-zirconium mini-implants placed for mandibular overdentures using non-guided surgery","authors":"Cláudio Rodrigues Leles, Leuçon de Oliveira Moura-Neto, Jésio Rodrigues Silva, Lays Noleto Nascimento, Thalita Fernandes Fleury Curado, Nadia Lago Costa, Martin Schimmel, Gerald McKenna","doi":"10.1111/clr.14335","DOIUrl":"10.1111/clr.14335","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the relative position of mini-implants to retain a mandibular overdenture, according to the surgical protocol, technical and anatomical factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Mandibular cone-beam computed tomography (CBCT) scans were analyzed for 73 patients who received four one-piece titanium-zirconium mini-implants. Drilling was performed using a 1.6 mm needle drill and a 2.2 mm Pilot Drill, according to the bone density with a surgical stent. Post-insertion CBCT images in DICOM format were analyzed using the E-Vol-DX software with BAR filters. Divergence angle between implants and between implants and the overdenture path of insertion was measured using CliniView 10.2.6 software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Divergence between implants ranged from 0° to 22.3° (mean = 4.2; SD = 3.7) in the lateral and from 0° to 26.2° (mean = 5.3; SD = 4.1) in the frontal projections (<i>p</i> < .001). Only 1 (0.2%) and 3 (0.7%) of the measurements were higher than 20° in the lateral and frontal views, respectively. The mean angulations between the implant and the path of insertion for the overdenture were 9.3° (SD = 7.5) and 4.0° (SD = 2.9) for the lateral and frontal views, respectively (<i>p</i> < .001). Regression analyses showed a significant association between the divergence of implants and the frontal view projection (<i>p</i> < .001), greater distance between the paired implants (<i>p</i> = .017), the flapped surgical protocol (<i>p</i> = .002), higher final insertion torque (<i>p</i> = .011), and deeper preparation with the needle drill (<i>p</i> < .001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The mini-implants were placed with low divergence angles and satisfactory parallelism. Factors including shorter distances between the implants, higher density bone, and a flapless surgical approach all contributed positively to improved parallelism of the mini-implants.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 11","pages":"1475-1484"},"PeriodicalIF":4.8,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone volume and height changes for lateral window sinus floor elevation using two types of deproteinized bovine bone mineral: A retrospective cohort study of 1–4 years 使用两种去蛋白牛骨矿物质抬高侧窗窦底的骨量和高度变化：一项为期 1-4 年的回顾性队列研究。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-07-23 DOI: 10.1111/clr.14337

Pei Xiao, Cong Chen, Xiaoting Shen, Antian Xu, Mufeed Ahmed Sharaf, Hongye Lu, Fuming He

Objective

To compare bone volume and height changes of two types of deproteinized bovine bone mineral (DBBM) for lateral window sinus floor elevation (LSFE) with simultaneous implant placement.

Materials and Methods

This retrospective cohort study involved 72 patients who underwent LSFE using low-temperature sintered cancellous bone-derived DBBM (C-DBBM) or high-temperature two-step sintered epiphyseal-derived DBBM (E-DBBM). Cone-beam computed tomography (CBCT) was acquired preoperatively, immediately postoperatively, 6 months and 1–4 years post-surgery. Bone volume (BV), apical bone height (ABH), endo-sinus bone gain (ESBG), and crestal bone level (CBL) were evaluated through three-dimensional fitting and superimposition. Linear mixed models (LMM) were employed to analyze factors influencing the reduction of BV (ΔBV) and ESBG (ΔESBG).

Results

The E-DBBM group showed no significant change in BV 1–4 years post-surgery, while the C-DBBM group demonstrated a significant reduction (p = .006) with volume stability of 85.86%. Bone height in the E-DBBM group increased at 6 months and subsequently decreased at 1–4 years (p = .003). In the C-DBBM group, it decreased at 6 months (p = .014), then further decreased at 1–4 years (p = .001). ΔESBG was lower in the E-DBBM group than the C-DBBM group from immediate postoperative to 1–4 years (p = .009). LMM showed graft material type was the primary factor influencing ΔBV (p = .026) and ΔESBG (p = .003).

Conclusions

Within the limitations of this study, both types of DBBM could achieve favorable clinical outcomes. E-DBBM demonstrated enhanced stability in maintaining bone volume and height.

摘要比较两种类型的去蛋白牛骨矿物质（DBBM）用于侧窗窦底抬高术（LSFE）并同时植入种植体的骨量和高度变化：这项回顾性队列研究涉及 72 例使用低温烧结松质骨衍生 DBBM（C-DBBM）或高温两步烧结骺端衍生 DBBM（E-DBBM）进行 LSFE 的患者。分别在术前、术后即刻、术后 6 个月和术后 1-4 年进行锥形束计算机断层扫描（CBCT）。通过三维拟合和叠加评估了骨量（BV）、根尖骨高（ABH）、窦内骨增量（ESBG）和嵴骨水平（CBL）。采用线性混合模型（LMM）分析影响 BV（ΔBV）和 ESBG（ΔESBG）降低的因素：结果：E-DBBM组术后1-4年的BV无明显变化，而C-DBBM组显著降低（p = .006），体积稳定率为85.86%。E-DBBM 组的骨高在 6 个月时增加，随后在 1-4 年时降低（p = .003）。C-DBBM 组的骨高在 6 个月时降低（p = .014），然后在 1-4 年时进一步降低（p = .001）。从术后即刻到 1-4 年，E-DBBM 组的ΔESBG 低于 C-DBBM 组（p = .009）。LMM显示移植物材料类型是影响ΔBV（p = .026）和ΔESBG（p = .003）的主要因素：结论：在本研究的限制条件下，两种类型的 DBBM 都能获得良好的临床效果。E-DBBM在维持骨量和骨高方面表现出更强的稳定性。

{"title":"Bone volume and height changes for lateral window sinus floor elevation using two types of deproteinized bovine bone mineral: A retrospective cohort study of 1–4 years","authors":"Pei Xiao, Cong Chen, Xiaoting Shen, Antian Xu, Mufeed Ahmed Sharaf, Hongye Lu, Fuming He","doi":"10.1111/clr.14337","DOIUrl":"10.1111/clr.14337","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare bone volume and height changes of two types of deproteinized bovine bone mineral (DBBM) for lateral window sinus floor elevation (LSFE) with simultaneous implant placement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This retrospective cohort study involved 72 patients who underwent LSFE using low-temperature sintered cancellous bone-derived DBBM (C-DBBM) or high-temperature two-step sintered epiphyseal-derived DBBM (E-DBBM). Cone-beam computed tomography (CBCT) was acquired preoperatively, immediately postoperatively, 6 months and 1–4 years post-surgery. Bone volume (BV), apical bone height (ABH), endo-sinus bone gain (ESBG), and crestal bone level (CBL) were evaluated through three-dimensional fitting and superimposition. Linear mixed models (LMM) were employed to analyze factors influencing the reduction of BV (ΔBV) and ESBG (ΔESBG).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The E-DBBM group showed no significant change in BV 1–4 years post-surgery, while the C-DBBM group demonstrated a significant reduction (<i>p</i> = .006) with volume stability of 85.86%. Bone height in the E-DBBM group increased at 6 months and subsequently decreased at 1–4 years (<i>p</i> = .003). In the C-DBBM group, it decreased at 6 months (<i>p</i> = .014), then further decreased at 1–4 years (<i>p</i> = .001). ΔESBG was lower in the E-DBBM group than the C-DBBM group from immediate postoperative to 1–4 years (<i>p</i> = .009). LMM showed graft material type was the primary factor influencing ΔBV (<i>p</i> = .026) and ΔESBG (<i>p</i> = .003).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Within the limitations of this study, both types of DBBM could achieve favorable clinical outcomes. E-DBBM demonstrated enhanced stability in maintaining bone volume and height.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 11","pages":"1493-1505"},"PeriodicalIF":4.8,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative osseointegration of hydrophobic tissue-level tapered implants—A preclinical in vivo study 疏水性组织级锥形植入物的骨结合对比--临床前体内研究

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-07-20 DOI: 10.1111/clr.14318

Jean-Claude Imber, Azita Khandanpour, Andrea Roccuzzo, Delia R. Irani, Dieter D. Bosshardt, Anton Sculean, Benjamin E. Pippenger

Purpose

To histometrically compare the osseointegration and crestal bone healing of a novel tapered, self-cutting tissue-level test implant with a standard tissue-level control implant in a submerged healing regimen.

Materials and Methods

In a mandibular minipig model, implants were inserted and evaluated histometrically after a healing period of 3, 6, and 12 weeks. The primary outcome was the evaluation of bone-to-implant contact (BIC) and secondary outcomes were primary stability as per insertion torque and first BIC (fBIC). Outcomes for the test and control implants were compared using Wilcoxon signed-rank tests and mixed linear regression models.

Results

Insertion torque values were significantly higher for the test (50.0 ± 26.4 Ncm) compared to the control implants (35.2 ± 19.7 Ncm, p = .0071). BIC values of test implants were non-inferior to those of control implants over the investigated study period. After 12 weeks, the corresponding values measured were 81.62 ± 11.12% and 90.41 ± 4.81% (p = .1763) for test and control implants, respectively. Similarly, no statistical difference was found for fBIC values, except for the 12 weeks outcome that showed statistically lower values for the test (−675.58 ± 590.88 μm) compared to control implants (−182.75 ± 197.40 μm, p = .0068).

Conclusions

Novel self-cutting tissue-level implants demonstrated noninferior osseointegration and crestal bone height maintenance to the tissue-level implants. Histometric outcomes between both implants demonstrated test implants were statistically noninferior to control implants, despite substantial differences in the bone engagement mechanism and resulting differences in insertion torque and qualitative bone healing patterns.

目的比较新型锥形自切组织水平试验种植体与标准组织水平对照种植体在水下愈合过程中的骨结合和骨嵴愈合情况。主要结果是骨与种植体接触（BIC）的评估，次要结果是根据插入扭矩和首次骨与种植体接触（fBIC）计算的主要稳定性。使用 Wilcoxon 符号秩检验和混合线性回归模型对试验种植体和对照种植体的结果进行比较。结果试验种植体的插入扭矩值（50.0 ± 26.4 Ncm）明显高于对照种植体（35.2 ± 19.7 Ncm，p = .0071）。在研究期间，试验种植体的 BIC 值与对照种植体相比没有劣势。12 周后，测试种植体和对照种植体的相应测量值分别为 81.62 ± 11.12% 和 90.41 ± 4.81%（p = .1763）。同样，fBIC 值也没有发现统计学差异，只是在 12 周后，测试值（-675.58 ± 590.88 μm）低于对照种植体（-182.75 ± 197.40 μm，p = .0068）。两种种植体之间的组织计量结果表明，尽管骨啮合机制存在很大差异，导致插入扭矩和骨愈合模式的不同，但从统计学角度来看，试验种植体并不逊色于对照种植体。

{"title":"Comparative osseointegration of hydrophobic tissue-level tapered implants—A preclinical in vivo study","authors":"Jean-Claude Imber, Azita Khandanpour, Andrea Roccuzzo, Delia R. Irani, Dieter D. Bosshardt, Anton Sculean, Benjamin E. Pippenger","doi":"10.1111/clr.14318","DOIUrl":"10.1111/clr.14318","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To histometrically compare the osseointegration and crestal bone healing of a novel tapered, self-cutting tissue-level test implant with a standard tissue-level control implant in a submerged healing regimen.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In a mandibular minipig model, implants were inserted and evaluated histometrically after a healing period of 3, 6, and 12 weeks. The primary outcome was the evaluation of bone-to-implant contact (BIC) and secondary outcomes were primary stability as per insertion torque and first BIC (fBIC). Outcomes for the test and control implants were compared using Wilcoxon signed-rank tests and mixed linear regression models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Insertion torque values were significantly higher for the test (50.0 ± 26.4 Ncm) compared to the control implants (35.2 ± 19.7 Ncm, <i>p</i> = .0071). BIC values of test implants were non-inferior to those of control implants over the investigated study period. After 12 weeks, the corresponding values measured were 81.62 ± 11.12% and 90.41 ± 4.81% (<i>p</i> = .1763) for test and control implants, respectively. Similarly, no statistical difference was found for fBIC values, except for the 12 weeks outcome that showed statistically lower values for the test (−675.58 ± 590.88 μm) compared to control implants (−182.75 ± 197.40 μm, <i>p =</i> .0068).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Novel self-cutting tissue-level implants demonstrated noninferior osseointegration and crestal bone height maintenance to the tissue-level implants. Histometric outcomes between both implants demonstrated test implants were statistically noninferior to control implants, despite substantial differences in the bone engagement mechanism and resulting differences in insertion torque and qualitative bone healing patterns.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 10","pages":"1299-1309"},"PeriodicalIF":4.8,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141730518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors affecting radiographic marginal bone resorption at dental implants in function for at least 5 years: A multicenter retrospective study 影响牙科植入物至少 5 年功能的放射学边缘骨吸收的因素：一项多中心回顾性研究。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-07-15 DOI: 10.1111/clr.14327

Leonardo Trombelli, Roberto Farina, Cristiano Tomasi, Fabio Vignoletti, Guerino Paolantoni, Francesco Giordano, Luca Ortensi, Anna Simonelli

Objective

To evaluate the influence of patient and implant-related factors on the changes of marginal bone levels (MBL) at implants with a follow-up ≥5 years.

Materials and Methods

At baseline (within 6 months from prosthetic insertion) and long-term (≥5 years after implant placement) visits, interproximal (mesial and distal) MBL were radiographically evaluated. To analyze factors predicting MBL change, the site (either mesial or distal) showing the highest MBL change (hChMBL site) was identified for each implant. Multilevel regression models were built to explain MBL change as well as the probability for a bone loss ≥2 mm at long-term.

Results

942 implants in 312 patients with a mean follow-up of 8.02 ± 2.5 years were analyzed. MBL change was significantly predicted by baseline MBL, oral bisphosphonate (BP) intake, history of periodontitis, diabetes, and super-hydrophilic implant surface. Higher risk for a bone loss ≥2 mm was observed in patients with history of periodontitis (OR = 9.52, 95% CI 0.72–3.79) and taking BP (OR = 6.84, 95% CI 0.21–3.63). Mandibular implants had higher odds for bone loss ≥2 mm compared to maxillary implants (OR = 3, 95% CI 0.39–1.87).

Conclusions

The findings of the present study contribute to the identification of specific clinical scenarios at higher risk for implant-supporting bone loss that need to be strictly monitored during maintenance.

目的：评估患者和种植体相关因素对种植体边缘骨水平（MBL）变化的影响：评估患者和种植体相关因素对随访≥5年的种植体边缘骨水平（MBL）变化的影响：在基线（植入修复体后 6 个月内）和长期（植入种植体后≥5 年）随访时，对近侧（中侧和远侧）边缘骨水平进行影像学评估。为了分析预测 MBL 变化的因素，确定了每个种植体 MBL 变化最大的部位（中间或远端）（hChMBL 位点）。建立多层次回归模型来解释 MBL 变化以及长期骨量损失≥2 mm 的概率：结果：分析了 312 名患者的 942 个种植体，平均随访时间为 8.02 ± 2.5 年。基线 MBL、口服双膦酸盐 (BP)、牙周炎病史、糖尿病和超亲水性种植体表面对 MBL 的变化有明显的预测作用。有牙周炎病史（OR = 9.52，95% CI 0.72-3.79）和服用 BP（OR = 6.84，95% CI 0.21-3.63）的患者骨质流失≥2 毫米的风险更高。与上颌种植体相比，下颌种植体骨质流失≥2 mm的几率更高（OR = 3，95% CI 0.39-1.87）：本研究结果有助于确定种植体支持骨质流失风险较高的特定临床情况，在维护过程中需要严格监控。

{"title":"Factors affecting radiographic marginal bone resorption at dental implants in function for at least 5 years: A multicenter retrospective study","authors":"Leonardo Trombelli, Roberto Farina, Cristiano Tomasi, Fabio Vignoletti, Guerino Paolantoni, Francesco Giordano, Luca Ortensi, Anna Simonelli","doi":"10.1111/clr.14327","DOIUrl":"10.1111/clr.14327","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the influence of patient and implant-related factors on the changes of marginal bone levels (MBL) at implants with a follow-up ≥5 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>At baseline (within 6 months from prosthetic insertion) and long-term (≥5 years after implant placement) visits, interproximal (mesial and distal) MBL were radiographically evaluated. To analyze factors predicting MBL change, the site (either mesial or distal) showing the highest MBL change (hChMBL site) was identified for each implant. Multilevel regression models were built to explain MBL change as well as the probability for a bone loss ≥2 mm at long-term.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>942 implants in 312 patients with a mean follow-up of 8.02 ± 2.5 years were analyzed. MBL change was significantly predicted by baseline MBL, oral bisphosphonate (BP) intake, history of periodontitis, diabetes, and super-hydrophilic implant surface. Higher risk for a bone loss ≥2 mm was observed in patients with history of periodontitis (OR = 9.52, 95% CI 0.72–3.79) and taking BP (OR = 6.84, 95% CI 0.21–3.63). Mandibular implants had higher odds for bone loss ≥2 mm compared to maxillary implants (OR = 3, 95% CI 0.39–1.87).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings of the present study contribute to the identification of specific clinical scenarios at higher risk for implant-supporting bone loss that need to be strictly monitored during maintenance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 11","pages":"1406-1417"},"PeriodicalIF":4.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-dose, standard, and high-resolution cone beam computed tomography for alveolar bone measurements related to implant planning: An ex vivo study in human specimens 低剂量、标准和高分辨率锥形束计算机断层扫描用于与种植规划相关的牙槽骨测量：人体标本的体外研究。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-07-05 DOI: 10.1111/clr.14326

Laurits Kaaber, Louise Hauge Matzen, Rubens Spin-Neto, Lars Schropp

Aim

To evaluate the performance of low-dose cone beam computed tomography (CBCT) protocols with regard to linear bone measurements in the posterior mandible for implant planning compared with higher dose protocols.

Materials and Methods

Forty-two edentulous posterior sites in human cadaveric mandibles were imaged in three CBCT scanners using three or four protocols with varying exposure parameters to achieve lower dose. Co-registration was performed to generate sagittal and cross-sectional image sections representative of the implant site. Three observers measured bone height, from the alveolar crest to the mandibular canal, and width, three mm from the top of the alveolar crest. Intra- and interobserver reproducibility were assessed for the cases rated as nonmeasurable as well as for completed measurements. The measurements were analyzed using paired t-tests for differences among the CBCT protocols and the frequency distribution of nonmeasurable cases with a Pearson Chi-square test.

Results

Reproducibility for registering nonmeasurable cases varied among observers; however, no consistent significant differences were found in the frequency distribution of these cases among observers, units, and protocols. Intraclass correlation coefficients (ICC) were >0.9 for all measurements of bone height and width. Mean differences of <0.5 mm were found regardless of protocol; however, one observer did in some cases produce larger differences.

Conclusion

Linear bone measurements did not differ significantly and could be performed with excellent reliability, using low-dose CBCT protocols compared with standard and high-resolution ones. Varying approaches for rating nonmeasurable cases were found, indicating differences in diagnostic strategies related to implant planning among observers.

目的：与高剂量锥形束计算机断层扫描（CBCT）相比，评估低剂量锥形束计算机断层扫描（CBCT）方案在下颌骨后部种植规划线性骨测量方面的性能：在三台 CBCT 扫描仪上对人类尸体下颌骨后部的 42 个无牙部位进行成像，采用三或四种不同曝光参数的方案，以达到较低剂量。通过联合注册生成代表种植部位的矢状和横截面图像切片。三名观察者测量了从牙槽嵴到下颌管的骨高度，以及从牙槽嵴顶部起三毫米的宽度。对被评为不可测量的病例以及完成测量的病例进行了观察者内部和观察者之间的再现性评估。使用配对 t 检验分析 CBCT 方案之间的差异，并使用皮尔逊卡方检验分析不可测量病例的频率分布：结果：不同观察者登记不可测量病例的再现性各不相同；但这些病例的频率分布在观察者、单位和方案之间没有发现一致的显著差异。所有骨高和骨宽测量的类内相关系数（ICC）均大于 0.9。结论与标准和高分辨率方案相比，使用低剂量 CBCT 方案进行线性骨测量没有明显差异，而且可靠性极高。对不可测量病例的评级方法各不相同，这表明观察者在与种植规划相关的诊断策略方面存在差异。

{"title":"Low-dose, standard, and high-resolution cone beam computed tomography for alveolar bone measurements related to implant planning: An ex vivo study in human specimens","authors":"Laurits Kaaber, Louise Hauge Matzen, Rubens Spin-Neto, Lars Schropp","doi":"10.1111/clr.14326","DOIUrl":"10.1111/clr.14326","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the performance of low-dose cone beam computed tomography (CBCT) protocols with regard to linear bone measurements in the posterior mandible for implant planning compared with higher dose protocols.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Forty-two edentulous posterior sites in human cadaveric mandibles were imaged in three CBCT scanners using three or four protocols with varying exposure parameters to achieve lower dose. Co-registration was performed to generate sagittal and cross-sectional image sections representative of the implant site. Three observers measured bone height, from the alveolar crest to the mandibular canal, and width, three mm from the top of the alveolar crest. Intra- and interobserver reproducibility were assessed for the cases rated as <i>nonmeasurable</i> as well as for completed measurements. The measurements were analyzed using paired <i>t</i>-tests for differences among the CBCT protocols and the frequency distribution of nonmeasurable cases with a Pearson Chi-square test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Reproducibility for registering nonmeasurable cases varied among observers; however, no consistent significant differences were found in the frequency distribution of these cases among observers, units, and protocols. Intraclass correlation coefficients (ICC) were >0.9 for all measurements of bone height and width. Mean differences of <0.5 mm were found regardless of protocol; however, one observer did in some cases produce larger differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Linear bone measurements did not differ significantly and could be performed with excellent reliability, using low-dose CBCT protocols compared with standard and high-resolution ones. Varying approaches for rating nonmeasurable cases were found, indicating differences in diagnostic strategies related to implant planning among observers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 11","pages":"1394-1405"},"PeriodicalIF":4.8,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of depression and the antidepressant fluoxetine on osseointegration—A pre-clinical in vivo experimental study 抑郁症和抗抑郁药氟西汀对骨结合的影响--一项临床前体内实验研究。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-07-04 DOI: 10.1111/clr.14323

Yundeng Xiaowen, Jingxuan Zhu, Mingming Gong, Ge Meng, Renran Tan, Yanbing Zhang, Zhiyu Chen

Objective

The aim of this study was to explore the effect of depression and selective serotonin reuptake inhibitors on implant osseointegration and bone healing.

Methods

Forty-eight 6- to 8-week-old SPF Sprague–Dawley male rats were randomly divided into four groups: the Control group, the Fluoxetine group, the Depression group and the De&Flu group. The rats in the Depression group and the De&Flu group were subjected to a depression modelling process, and the rats in the Control group and the Fluoxetine group were raised normally. Then, a titanium implant was placed in the right tibia of each rat. In the Fluoxetine group and De&Flu group, fluoxetine was injected subcutaneously daily, while subcutaneously injecting physiological saline in the Control group and Depression group. Collecting serum from the rats used for ELISA. The surgical area was cut for microcomputed tomography and histology observation.

Results

After 12 weeks, bone mineral density was lower in the De&Flu group than in the Control group, Depression group and Fluoxetine group. Bone mineral density was also lower in the Depression group and the Fluoxetine group than in the Control group. The percentage of bone–implant contact (BIC%) in De&Flu rats was lower than in the Control, Depression and Fluoxetine groups. The BIC% in the Depression group and the Fluoxetine group was lower than in the Control group.

Conclusions

Depression and fluoxetine negatively affect bone density and implant osseointegration independently, and this damaging effect is exacerbated when both factors are present. The mechanism may be related to the dysregulation of the hypothalamic–pituitary–adrenal axis and inflammation in the body.

研究目的本研究旨在探讨抑郁症和选择性5-羟色胺再摄取抑制剂对种植体骨结合和骨愈合的影响：将 48 只 6 至 8 周大的 SPF Sprague-Dawley 雄性大鼠随机分为四组：对照组、氟西汀组、抑郁组和去氟组。抑郁组和去甲流感组的大鼠接受抑郁建模过程，而对照组和氟西汀组的大鼠则正常饲养。然后，在每只大鼠的右胫骨上植入一个钛植入物。氟西汀组和De&Flu组每天皮下注射氟西汀，对照组和抑郁组每天皮下注射生理盐水。收集用于 ELISA 的大鼠血清。切开手术区域进行微计算机断层扫描和组织学观察：12周后，去甲流感组的骨矿密度低于对照组、抑郁组和氟西汀组。抑郁组和氟西汀组的骨矿物质密度也低于对照组。去氟大鼠的骨-植入物接触百分比（BIC%）低于对照组、抑郁组和氟西汀组。抑郁组和氟西汀组的 BIC% 低于对照组：结论：抑郁和氟西汀会单独对骨密度和种植体骨结合产生负面影响，当这两种因素同时存在时，这种破坏性影响会加剧。其机制可能与下丘脑-垂体-肾上腺轴调节失调和体内炎症有关。

{"title":"Effect of depression and the antidepressant fluoxetine on osseointegration—A pre-clinical in vivo experimental study","authors":"Yundeng Xiaowen, Jingxuan Zhu, Mingming Gong, Ge Meng, Renran Tan, Yanbing Zhang, Zhiyu Chen","doi":"10.1111/clr.14323","DOIUrl":"10.1111/clr.14323","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to explore the effect of depression and selective serotonin reuptake inhibitors on implant osseointegration and bone healing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty-eight 6- to 8-week-old SPF Sprague–Dawley male rats were randomly divided into four groups: the Control group, the Fluoxetine group, the Depression group and the De&Flu group. The rats in the Depression group and the De&Flu group were subjected to a depression modelling process, and the rats in the Control group and the Fluoxetine group were raised normally. Then, a titanium implant was placed in the right tibia of each rat. In the Fluoxetine group and De&Flu group, fluoxetine was injected subcutaneously daily, while subcutaneously injecting physiological saline in the Control group and Depression group. Collecting serum from the rats used for ELISA. The surgical area was cut for microcomputed tomography and histology observation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 12 weeks, bone mineral density was lower in the De&Flu group than in the Control group, Depression group and Fluoxetine group. Bone mineral density was also lower in the Depression group and the Fluoxetine group than in the Control group. The percentage of bone–implant contact (BIC%) in De&Flu rats was lower than in the Control, Depression and Fluoxetine groups. The BIC% in the Depression group and the Fluoxetine group was lower than in the Control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Depression and fluoxetine negatively affect bone density and implant osseointegration independently, and this damaging effect is exacerbated when both factors are present. The mechanism may be related to the dysregulation of the hypothalamic–pituitary–adrenal axis and inflammation in the body.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 10","pages":"1355-1366"},"PeriodicalIF":4.8,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early implant placement versus ridge preservation and delayed implant placement: Analysis of profilometric, clinician- and patient-reported outcomes from a two-centre RCT 早期植入种植体与保留牙脊和延迟植入种植体：对一项双中心 RCT 的轮廓测量、临床医生和患者报告结果的分析。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-07-04 DOI: 10.1111/clr.14325

Daniel Thoma, Alfonso Gil, Thomas de Bruyckere, Ronald E. Jung, Shunsuke Fukuba, Axelle Ickroth, Franz J. Strauss, Jan Cosyn

Objectives

To compare early implant placement (EP) to alveolar ridge preservation and delayed implant placement (ARP/DP) in terms of contour changes, along with clinician- and patient-reported outcome measures (PROMs) until the delivery of the implant-supported restoration.

Materials and Methods

Patients with a failing single tooth in the maxilla or mandible were recruited in two centres. After tooth extraction, patients were randomly assigned (1:1) to either EP or ARP/DP. At abutment connection and crown delivery, the buccal contour changes at 3 mm below the mucosal margin (primary outcome) along with clinician- (ease of treatment) and patient-reported outcomes were assessed using numeric rating scales and OHIP-14.

Results

A total of 46 patients were analysed. The mean buccal contour at abutment connection decreased by −1.2 ± 0.6 mm in group EP and −1.6 ± 0.8 mm in group ARP/DP (estimated mean difference; 0.45 [95%CI, −0.02; 0.94]; p = .061) with no significant differences between the groups. ARP/DP was consistently easier than EP across all stages of the surgery (estimated mean difference; 2.0 [95%CI, 1.3; 2.7] p < .001): during flap elevation (EP: 4.8 vs. ARP/DP: 1.6), implant placement (EP: 5.7 vs. ARP/DP: 2.2) and wound closure (EP: 3.4 vs. ARP/DP: 1.6). Both interventions improved quality of life but patients who underwent ARP/DP were significantly more satisfied at the time of crown delivery (ARP/DP: 9.6 vs. EP: 9.1, p = .02).

Conclusions

EP and ARP/DP show no significant differences in buccal contour changes, aesthetics and patient-reported outcomes. However, ARP/DP is an easier procedure at all stages of the surgery compared to EP and could therefore be the preferred therapy for less experienced clinicians.

目的比较早期种植体植入（EP）与牙槽嵴保留和延迟种植体植入（ARP/DP）在轮廓变化、临床医生和患者报告的结果测量（PROMs）方面的差异，直至提供种植体支持的修复体：在两个中心招募上颌或下颌单颗牙齿失败的患者。拔牙后，患者被随机分配（1:1）EP 或 ARP/DP。在基台连接和牙冠交付时，使用数字评分表和 OHIP-14 评估粘膜边缘下 3 毫米处的颊面轮廓变化（主要结果）以及临床医生（治疗难易程度）和患者报告的结果：结果：共对 46 名患者进行了分析。EP组患者基台连接处的平均颊面轮廓下降了-1.2 ± 0.6 mm，ARP/DP组患者基台连接处的平均颊面轮廓下降了-1.6 ± 0.8 mm（估计平均差异；0.45 [95%CI, -0.02; 0.94]; p = .061），组间无显著差异。在手术的所有阶段，ARP/DP 始终比 EP 更容易（估计平均差异；2.0 [95%CI, 1.3; 2.7] p 结论：EP 和 ARP/DP 在颊部轮廓变化、美学和患者报告结果方面没有明显差异。不过，与 EP 相比，ARP/DP 在手术的各个阶段都更容易操作，因此对于经验不足的临床医生来说，ARP/DP 可能是首选疗法。

{"title":"Early implant placement versus ridge preservation and delayed implant placement: Analysis of profilometric, clinician- and patient-reported outcomes from a two-centre RCT","authors":"Daniel Thoma, Alfonso Gil, Thomas de Bruyckere, Ronald E. Jung, Shunsuke Fukuba, Axelle Ickroth, Franz J. Strauss, Jan Cosyn","doi":"10.1111/clr.14325","DOIUrl":"10.1111/clr.14325","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare early implant placement (EP) to alveolar ridge preservation and delayed implant placement (ARP/DP) in terms of contour changes, along with clinician- and patient-reported outcome measures (PROMs) until the delivery of the implant-supported restoration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Patients with a failing single tooth in the maxilla or mandible were recruited in two centres. After tooth extraction, patients were randomly assigned (1:1) to either EP or ARP/DP. At abutment connection and crown delivery, the buccal contour changes at 3 mm below the mucosal margin (primary outcome) along with clinician- (ease of treatment) and patient-reported outcomes were assessed using numeric rating scales and OHIP-14.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 46 patients were analysed. The mean buccal contour at abutment connection decreased by −1.2 ± 0.6 mm in group EP and −1.6 ± 0.8 mm in group ARP/DP (estimated mean difference; 0.45 [95%CI, −0.02; 0.94]; <i>p</i> = .061) with no significant differences between the groups. ARP/DP was consistently easier than EP across all stages of the surgery (estimated mean difference; 2.0 [95%CI, 1.3; 2.7] <i>p</i> < .001): during flap elevation (EP: 4.8 vs. ARP/DP: 1.6), implant placement (EP: 5.7 vs. ARP/DP: 2.2) and wound closure (EP: 3.4 vs. ARP/DP: 1.6). Both interventions improved quality of life but patients who underwent ARP/DP were significantly more satisfied at the time of crown delivery (ARP/DP: 9.6 vs. EP: 9.1, <i>p</i> = .02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>EP and ARP/DP show no significant differences in buccal contour changes, aesthetics and patient-reported outcomes. However, ARP/DP is an easier procedure at all stages of the surgery compared to EP and could therefore be the preferred therapy for less experienced clinicians.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 11","pages":"1382-1393"},"PeriodicalIF":4.8,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Ultrastructural study by backscattered electron imaging and elemental microanalysis of biomaterial-to-bone interface and mineral degradation of bovine xenografts in maxillary sinus floor elevation 回放：通过反向散射电子成像和元素显微分析对上颌窦底隆起的生物材料与骨界面以及牛异种移植物的矿物质降解进行超微结构研究。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-07-02 DOI: 10.1111/clr.14305

M. P. Ramírez-Fernández, J. L. Calvo-Guirado, R. A. Delgado-Ruiz, J. E. Maté-Sánchez del Val, B. Negri, M. Peñarrocha Diago, “Ultrastructural study by backscattered electron imaging and elemental microanalysis of biomaterial-to-bone interface and mineral degradation of bovine xenografts in maxillary sinus floor elevation,” Clinical Oral Implants Research 24, no. 6 (2013): 645–651, https://doi.org/10.1111/j.1600-0501.2012.02439.x.

The above article, published online on 16 March 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Lisa J. A. Heitz-Mayfield; and John Wiley & Sons Ltd. The retraction has been agreed due to concerns raised by third parties on the data presented in the article. Several flaws and inconsistencies between results presented and experimental methods described were found. Specifically, instances of overlapping data within the article and with another publication authored by the same group have been found, despite the articles have different study designs. Accordingly, the editors consider the findings of this article unreliable and the conclusions to be invalid. The authors have been informed of the decision to retract the article. The corresponding author M. P. Ramírez-Fernández and co-author R. A. Delgado-Ruiz disagree with the decision of retraction. The remaining co-authors were not available for a final confirmation of the retraction.

P. Ramírez-Fernández, J. L. Calvo-Guirado, R. A. Delgado-Ruiz, J. E. Maté-Sánchez del Val, B. Negri, M. Peñarrocha Diago, "Ultrastructural study by backscattered electron imaging and elemental microanalysis of biomaterial-to-bone interface and mineral degradation of bovine xenografts in maxillary sinus floor elevation," Clinical Oral Implants Research 24, no：645-651, https://doi.org/10.1111/j.1600-0501.2012.02439.x。上述文章于 2012 年 3 月 16 日在线发表于 Wiley Online Library (wileyonlinelibrary.com)，经期刊主编 Lisa J. A. Heitz-Mayfield 和 John Wiley & Sons Ltd. 协议，该文章已被撤回。之所以同意撤稿，是因为第三方对文章中提供的数据提出了疑虑。我们发现文章中介绍的结果与实验方法之间存在若干缺陷和不一致之处。具体而言，尽管文章的研究设计不同，但发现文章中的数据与同一小组撰写的另一篇文章中的数据存在重叠。因此，编辑认为这篇文章的研究结果不可靠，结论无效。已将撤稿决定通知作者。通讯作者M. P. Ramírez-Fernández和合著者R. A. Delgado-Ruiz不同意撤稿决定。其余合著者无法最终确认撤稿决定。

{"title":"RETRACTION: Ultrastructural study by backscattered electron imaging and elemental microanalysis of biomaterial-to-bone interface and mineral degradation of bovine xenografts in maxillary sinus floor elevation","authors":"","doi":"10.1111/clr.14305","DOIUrl":"10.1111/clr.14305","url":null,"abstract":"<p>M. P. Ramírez-Fernández, J. L. Calvo-Guirado, R. A. Delgado-Ruiz, J. E. Maté-Sánchez del Val, B. Negri, M. Peñarrocha Diago, “Ultrastructural study by backscattered electron imaging and elemental microanalysis of biomaterial-to-bone interface and mineral degradation of bovine xenografts in maxillary sinus floor elevation,” <i>Clinical Oral Implants Research</i> 24, no. 6 (2013): 645–651, https://doi.org/10.1111/j.1600-0501.2012.02439.x.</p><p>The above article, published online on 16 March 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Lisa J. A. Heitz-Mayfield; and John Wiley & Sons Ltd. The retraction has been agreed due to concerns raised by third parties on the data presented in the article. Several flaws and inconsistencies between results presented and experimental methods described were found. Specifically, instances of overlapping data within the article and with another publication authored by the same group have been found, despite the articles have different study designs. Accordingly, the editors consider the findings of this article unreliable and the conclusions to be invalid. The authors have been informed of the decision to retract the article. The corresponding author M. P. Ramírez-Fernández and co-author R. A. Delgado-Ruiz disagree with the decision of retraction. The remaining co-authors were not available for a final confirmation of the retraction.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 9","pages":"1201"},"PeriodicalIF":4.8,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term retention and survival of cemented implant-supported zirconia and metal-ceramic single crowns: A retrospective study 粘接种植体支撑的氧化锆和金属陶瓷单冠的长期固位和存活：回顾性研究。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-07-02 DOI: 10.1111/clr.14321

P. Rammelsberg, A. L. Klotz

Objectives

To evaluate the effect of different cement types on the incidence of failure and loss of retention of zirconia and metal-ceramic single crowns (SCs) cemented on implant abutments.

Methods

We placed 567 implant-supported SCs in 358 patients and retrospectively evaluated long-term retention for up to 12.8 years. The frameworks were made from metal alloy (n = 307) or zirconia (n = 260). SCs were cemented with permanent (glass-ionomer cement; n = 376) or semipermanent cement (zinc oxide non-eugenol cement; n = 191) on standardized (n = 446) or customized (n = 121) abutments. Kaplan–Meier curves were used to calculate the incidence of decementation. Differences between survival curves were assessed with log-rank tests. Cox-regression analysis was performed to evaluate multiple risk factors.

Results

Of the 567 SCs, 22 failed because of technical complications and four because of implant loss. Loss of retention was observed in 50 SCs. Analysis revealed a 7% probability of loss of retention for zirconia and 16% for metal-ceramic SCs after 10 years (p = .011). After 5 years, loss of retention was higher for standardized abutments than for customized abutments (p = .014). The probability of loss of retention was higher with semipermanent than with permanent cement (p = .001). Cox-regression analysis revealed semipermanent cement as the only significant risk factor for SC failure (p = .026).

Conclusions

In contrast to semipermanent cement, permanent cement provides acceptable long-term retention of cemented implant-supported SCs. These possible positive effects of customized abutments have to be controlled with larger sample sizes.

目的评估不同粘接剂类型对种植体基台上粘接氧化锆和金属陶瓷单冠（SC）失败率和固位丧失的影响：我们为 358 名患者植入了 567 个种植体支持的单冠，并对长达 12.8 年的长期固位情况进行了回顾性评估。骨架由金属合金（307 例）或氧化锆（260 例）制成。在标准化（n = 446）或定制（n = 121）基台上用永久性（玻璃离子水泥；n = 376）或半永久性（氧化锌非丁香酚水泥；n = 191）水泥粘结 SC。Kaplan-Meier 曲线用于计算脱落发生率。生存曲线之间的差异通过对数秩检验进行评估。Cox回归分析用于评估多种风险因素：在 567 例 SC 中，22 例因技术并发症而失败，4 例因种植体脱落而失败。有 50 个 SC 出现了固位丧失。分析表明，10年后氧化锆种植体丧失固位的概率为7%，金属陶瓷种植体丧失固位的概率为16%（p = .011）。5 年后，标准基台的固位丧失率高于定制基台（p = .014）。半永久性骨水泥的固位丧失概率高于永久性骨水泥（p = .001）。Cox回归分析显示，半永久性骨水泥是SC失败的唯一重要风险因素（p = .026）：结论：与半永久性骨水泥相比，永久性骨水泥可为骨水泥种植体支持的 SC 提供可接受的长期固位。定制基台可能带来的这些积极影响还需要更大的样本量来控制。

{"title":"Long-term retention and survival of cemented implant-supported zirconia and metal-ceramic single crowns: A retrospective study","authors":"P. Rammelsberg, A. L. Klotz","doi":"10.1111/clr.14321","DOIUrl":"10.1111/clr.14321","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the effect of different cement types on the incidence of failure and loss of retention of zirconia and metal-ceramic single crowns (SCs) cemented on implant abutments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We placed 567 implant-supported SCs in 358 patients and retrospectively evaluated long-term retention for up to 12.8 years. The frameworks were made from metal alloy (<i>n</i> = 307) or zirconia (<i>n</i> = 260). SCs were cemented with permanent (glass-ionomer cement; <i>n</i> = 376) or semipermanent cement (zinc oxide non-eugenol cement; <i>n</i> = 191) on standardized (<i>n</i> = 446) or customized (<i>n</i> = 121) abutments. Kaplan–Meier curves were used to calculate the incidence of decementation. Differences between survival curves were assessed with log-rank tests. Cox-regression analysis was performed to evaluate multiple risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 567 SCs, 22 failed because of technical complications and four because of implant loss. Loss of retention was observed in 50 SCs. Analysis revealed a 7% probability of loss of retention for zirconia and 16% for metal-ceramic SCs after 10 years (<i>p</i> = .011). After 5 years, loss of retention was higher for standardized abutments than for customized abutments (<i>p</i> = .014). The probability of loss of retention was higher with semipermanent than with permanent cement (<i>p</i> = .001). Cox-regression analysis revealed semipermanent cement as the only significant risk factor for SC failure (<i>p</i> = .026).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In contrast to semipermanent cement, permanent cement provides acceptable long-term retention of cemented implant-supported SCs. These possible positive effects of customized abutments have to be controlled with larger sample sizes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 10","pages":"1335-1342"},"PeriodicalIF":4.8,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0