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Letter to the Editor-“Reply-letter to the editor” 致编辑的信--"致编辑的回信"。
IF 6.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-21 DOI: 10.1016/j.clnu.2024.11.031
Yoshiyasu Takefuji
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引用次数: 0
“Reply - Letter to the editor” - “Association of healthy and unhealthy plant-based diets with telomere length” "回复--致编辑的信"--"健康和不健康的植物性饮食与端粒长度的关系"。
IF 6.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-21 DOI: 10.1016/j.clnu.2024.11.032
Xiude Li , Meiling Li , Jing Cheng, Shixia Guan, Lili Hou, Shuang Zu, Le Yang, Hanhan Wu, Huixian Li, Yunshan Fan, Bao Zhang
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引用次数: 0
Letter to the editor – “Association of healthy and unhealthy plant-based diets with telomere length” 致编辑的信——“健康和不健康的植物性饮食与端粒长度的关系”。
IF 6.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-21 DOI: 10.1016/j.clnu.2024.11.030
Mo-Yao Tan, Ping Zhang, Ming Gao
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引用次数: 0
Vitamin B12 concentrations vary greatly in milk donated to a large provincial milk bank, and are influenced by supplementation and parity 在捐赠给一个大型省级母乳库的牛奶中,维生素B12的浓度差异很大,并受到补充和胎次的影响。
IF 6.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-19 DOI: 10.1016/j.clnu.2024.11.027
Adrianna Greco , Jo-Anna B. Baxter , Kathryn Walton , Susanne Aufreiter , Michael A. Pitino , Carleigh Jenkins , Samantha Ismail , Alex Kiss , Debbie Stone , Sharon L. Unger , Deborah L. O'Connor

Background & aims

Feeding parent's milk with supplemental donor milk (DM) is the optimal way to feed very low birth weight (VLBW) infants instead of formula; however, suboptimal neurodevelopment persists. This is believed due, in part, to suboptimal nutrition. Given vitamin B12's role in neurodevelopment and increased adoption of plant-based diets among females of child-bearing age, we aimed to determine the adequacy of vitamin B12 in DM (n = 380 donors) and associated donor characteristics.

Methods

Vitamin B12 was measured in consecutive raw DM donations received at the milk bank from March 2020–2021 using a validated competitive chemiluminescent enzyme immunoassay (IMMULITE 2000, Siemens). Donor characteristics were obtained from screening records and associations with milk vitamin B12 concentrations explored using a generalized additive model.

Results

Donors were 32 ± 4 years old (mean ± SD), and DM was expressed 98 ± 85 days postpartum. Vitamin B12 concentrations in DM had a median (25th, 75th percentile) of 232 (149, 373) pmol/L; 64 % had concentrations <310 pmol/L (common cut-off for inadequacy in healthy term-born infants). In a multivariable analysis, donors consuming a vitamin B12-containing supplement had higher DM vitamin B12 (β ± SE: 80.3 ± 25.4 pmol/L; p = 0.020) compared to those not taking a supplement. Primiparous donors had higher DM vitamin B12 than multiparous donors (36.7 ± 18.2 pmol/L greater; p = 0.044). No associations were observed for other donor characteristics.

Conclusion

Milk donated to a large human milk bank showed evidence of suboptimal vitamin B12; levels were associated with both donor vitamin B12-containing supplement use and parity. Further research as to whether and when milk bank donors are recommended to consume a supplement and the benefits and risks of routine vitamin B12 supplementation of DM-fed infants is warranted.
背景与目的:极低出生体重儿(VLBW)的最佳喂养方式是父母奶加供乳(DM)代替配方奶;然而,次优的神经发育仍然存在。人们认为,这在一定程度上是由于营养不佳。鉴于维生素B12在神经发育中的作用,以及育龄女性越来越多地采用植物性饮食,我们的目的是确定糖尿病患者(n = 380名供体)维生素B12的充足性和相关供体特征。方法:使用经过验证的竞争性化学发光酶免疫分析法(IMMULITE 2000, Siemens),对2020年3月至2021年3月在母乳库收到的连续原始DM捐赠物中测量维生素B12。从筛选记录中获得供体特征,并使用广义加性模型探索与牛奶维生素B12浓度的关系。结果:供体年龄为32±4岁(平均±SD),产后98±85 d出现DM。糖尿病患者维生素B12浓度中位数(25、75百分位数)为232(149、373)pmol/L;结论:捐赠给大型母乳库的母乳显示维生素B12不理想;水平与供体含维生素b12补充剂的使用和胎次有关。进一步的研究是否以及何时建议母乳银行的捐赠者补充维生素B12,以及对母乳喂养的婴儿常规补充维生素B12的益处和风险是有必要的。
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引用次数: 0
Water intake in athletes: Agreement between food records and isotope-dilution methods 运动员的水分摄入量:食物记录与同位素稀释法之间的一致性。
IF 6.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-15 DOI: 10.1016/j.clnu.2024.11.026
Filipe Jesus , Olivia Di Vincenzo , Rúben Francisco , Catarina L. Nunes , Emi Kondo , Paulo Rocha , Cláudia S. Minderico , Luís B. Sardinha , Dale A. Schoeller , Analiza M. Silva

Background

Although water intake (WI) is commonly estimated through self-reporting, its inaccuracy is reported. Water turnover (rH2O)-derived WI is the reference method; however, it is costly. The study aimed to validate alternative methods for determining WI in a group of athletes.

Methods

Eighty-two athletes (20.4 ± 5.1 years; 28 females) were included in this cross-sectional validation study. Doubly labelled water (DLW) determined rH2O and rH2O-derived WI by subtracting metabolic, transcutaneous, and inspired water from rH2O (reference). The rH2O components were determined by alternative approaches: i) average values of macronutrients instead of individual food records (DLW-derived WI); ii) estimating total energy expenditure (TEE) and rCO2 through a predictive equation instead of DLW (2H-derived WI); iii) estimating rH2O by prediction equation (equation-derived WI). Food records were employed to determine WI (food record-derived WI).

Results

Only DLW-derived WI showed no significant differences compared to reference in both sexes (females: 2 mL/day, p = 0.183; males: −4 mL/day, p = 0.118). 2H-derived WI showed significant but small differences (females: 23 mL/day, p = 0.001; males: 32 mL/day, p < 0.001) while food record-derived WI showed the largest differences (females: −924 mL/day, p < 0.001; males: −1504 mL/day, p < 0.001). DLW-derived and 2H-derived WI showed good performance [r2 > 0.987 and concordance correlation coefficient (CCC) > 0.993], while food record-derived WI showed poor performance [r2 < 0.031 and CCC < 0.133)].

Conclusion

Although some alternative approaches provide adequate estimates, DLW- and 2H-derived WI are the only valid methods to determine WI in our sample of competitive athletes. These approaches are less costly and could contribute to the development of WI guidelines for athletes. Food records underestimate WI, but evidence-based recommendations could reduce misrecordings.
背景:尽管水摄入量(WI)通常是通过自我报告来估算的,但有报告称其不准确。水周转率(rH2O)得出的水摄入量是一种参考方法,但成本较高。本研究旨在验证在一组运动员中测定水分摄入量的其他方法:方法:82 名运动员(20.4 ± 5.1 岁;28 名女性)参加了这项横断面验证研究。双标记水(DLW)通过从 rH2O(参考值)中减去代谢水、经皮水和吸入水来测定 rH2O 和 rH2O 衍生 WI。rH2O 成分是通过其他方法确定的:i) 用主要营养素的平均值代替单个食物记录(DLW 衍生 WI);ii) 通过预测方程代替 DLW 估算总能量消耗(TEE)和 rCO2(2H 衍生 WI);iii) 通过预测方程估算 rH2O(方程衍生 WI)。采用食物记录确定 WI(食物记录衍生 WI):结果:与参考值相比,两性只有 DLW 衍生的 WI 没有显著差异(女性:2 毫升/天,p = 0.183;男性:-4 毫升/天,p = 0.118)。2H 导出的 WI 显示出显著但较小的差异(女性:23 毫升/天,p = 0.001;男性:32 毫升/天,p 2H 导出的 WI 显示出良好的性能[r2 > 0.987 和一致性相关系数 (CCC) > 0.993],而食物记录导出的 WI 显示出较差的性能[r2 结论]:尽管一些替代方法能提供适当的估计值,但在我们的竞技运动员样本中,DLW 和 2H 导出的 WI 是确定 WI 的唯一有效方法。这些方法成本较低,有助于制定运动员的 WI 指南。食物记录低估了 WI,但基于证据的建议可减少错误记录。
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引用次数: 0
Reply - Letter to the editor entitled “Letter to editor - Dietary and lifestyle inflammation scores in relation to colorectal cancer recurrence and all-cause mortality: A longitudinal analysis” 回复--致编辑的信,题为 "致编辑的信--饮食和生活方式炎症评分与结直肠癌复发和全因死亡率的关系:纵向分析"。
IF 6.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-14 DOI: 10.1016/j.clnu.2024.11.018
Evertine Wesselink, Hendriek C. Boshuizen, Anne-Sophie van Lanen, Dieuwertje E. Kok, Jeroen W.G. Derksen, Karel C. Smit, Johannes H.W. de Wilt, Miriam Koopman, Anne M. May, Ellen Kampman, Fränzel J.B. van Duijnhoven
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引用次数: 0
Beetroot juice intake positively influenced gut microbiota and inflammation but failed to improve functional outcomes in adults with long COVID: A pilot randomized controlled trial 摄入甜菜根汁对肠道微生物群和炎症有积极影响,但未能改善长期慢性阻塞性肺病成人的功能预后:一项试点随机对照试验。
IF 6.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-14 DOI: 10.1016/j.clnu.2024.11.023
Riccardo Calvani , Ottavia Giampaoli , Federico Marini , Federica Del Chierico , Michele De Rosa , Giorgia Conta , Fabio Sciubba , Matteo Tosato , Anna Picca , Francesca Ciciarello , Vincenzo Galluzzo , Jacopo Gervasoni , Clara Di Mario , Luca Santoro , Barbara Tolusso , Mariangela Spagnoli , Alberta Tomassini , Walter Aureli , Francesca Toto , Stefania Pane , Francesco Landi
<div><h3>Background & aims</h3><div>Long-term effects of coronavirus disease 2019 (long COVID) develop in a substantial number of people following an acute COVID-19 episode. Red beetroot juice may have positive effects on multiple pathways involved in long COVID. The aim of this pilot study was to explore the impact of beetroot juice supplementation on physical function, gut microbiota, and systemic inflammation in adults with long COVID.</div></div><div><h3>Methods</h3><div>A single-center, double-blind, placebo-controlled randomized trial was conducted to test the effects of 14 days of beetroot juice supplementation, rich in nitrates and betalains, on functional and biological outcomes in adults aged between 20 and 60 years with long COVID. Participants were randomized 1:1 to receive either daily oral supplementation with 200 mL beetroot juice (∼600 mg nitrate) or placebo (∼60 mg nitrate) for 14 days. The primary endpoint was the change from baseline to day 14 in a fatigue resistance test. Secondary outcomes included the distance walked on the 6-min walk test, handgrip strength, and flow-mediated dilation. Secondary endpoints also included changes from baseline in circulating inflammatory mediators and metagenomic and fecal water metabolomic profiles. Partial least squares discriminant analysis (PLS−DA) models were built to evaluate the differences in biological variables associated with the interventions.</div></div><div><h3>Results</h3><div>Thirty-one participants were randomized in the study. Twenty-five of them (median (interquartile range) age 40 (10), 14 [56 %] women), received either beetroot juice (15) or placebo (10) and completed the study. At 14 days, fatigue resistance significantly improved from baseline (mean difference [standard error]: +21.8 [3.7] s; <em>p</em> < 0.001) with no significant differences between intervention groups. A significant increase from baseline in the distance walked on the 6-min walk test was observed (mean difference [standard error]: +30.0 [9.4] m; <em>p</em> = 0.03), which was not different between groups. Flow-mediated dilation did not differ between participants who received beetroot juice and those on placebo. PLS–DA models allowed correct classification of participants with 92.2 ± 4.4 % accuracy. Those who ingested red beetroot juice had a greater abundance of bacteria with well-known beneficial effects, including <em>Akkermansia</em>, <em>Oscillospira</em>, <em>Prevotella</em>, <em>Roseburia</em>, <em>Ruminococcaceae</em>, and <em>Turicibacter</em>, compared with placebo. Participants allocated to beetroot juice supplementation were also characterized by significantly higher levels of fecal nicotinate, trimethylamine, and markers of beetroot juice intake (e.g., 5,6-dihydroxyindole). Finally, higher levels of interferon gamma and macrophage inflammatory protein-1β were found in participants who consumed beetroot juice.</div></div><div><h3>Conclusion</h3><div>Beetroot juice supplementation for
背景与目的:冠状病毒疾病 2019(长 COVID)的长期影响会在相当多的人身上发生,这些人是在急性 COVID-19 发作之后出现的。红甜菜根汁可能会对涉及长COVID的多种途径产生积极影响。本试验研究旨在探索补充甜菜根汁对患有长COVID的成年人的身体功能、肠道微生物群和全身炎症的影响:方法:研究人员进行了一项单中心、双盲、安慰剂对照随机试验,以检测补充 14 天富含硝酸盐和甜菜苷的甜菜根汁对 20 至 60 岁患有长期 COVID 的成年人的功能和生物学结果的影响。参与者按 1:1 随机分配,在 14 天内每天口服补充 200 毫升甜菜根汁(600 毫克硝酸盐)或安慰剂(60 毫克硝酸盐)。主要终点是抗疲劳测试从基线到第 14 天的变化。次要结果包括 6 分钟步行测试的步行距离、手握力和血流介导的扩张。次要终点还包括循环炎症介质以及元基因组和粪水代谢组图谱从基线到第 14 天的变化。建立了偏最小二乘判别分析(PLS-DA)模型,以评估与干预措施相关的生物变量的差异:31名参与者被随机纳入研究。其中 25 人(中位数(四分位之间)年龄为 40 岁(10 人),14 [56 %] 为女性)接受了甜菜根汁(15 人)或安慰剂(10 人),并完成了研究。14 天后,抗疲劳能力与基线相比有了明显改善(平均差[标准误差]:+21.8 [3.7]:+21.8 [3.7] s; p 结论:补充甜菜根汁 2 天后,抗疲劳能力明显改善:与安慰剂相比,连续两周补充甜菜根汁并不能明显改善长期 COVID 患者的功能。在肠道微生物群组成(即益生菌种类增加)和炎症介质方面都观察到了有益的影响:试验已在 ClinicalTrials.gov 注册。标识符编号:NCT06535165。NCT06535165。
{"title":"Beetroot juice intake positively influenced gut microbiota and inflammation but failed to improve functional outcomes in adults with long COVID: A pilot randomized controlled trial","authors":"Riccardo Calvani ,&nbsp;Ottavia Giampaoli ,&nbsp;Federico Marini ,&nbsp;Federica Del Chierico ,&nbsp;Michele De Rosa ,&nbsp;Giorgia Conta ,&nbsp;Fabio Sciubba ,&nbsp;Matteo Tosato ,&nbsp;Anna Picca ,&nbsp;Francesca Ciciarello ,&nbsp;Vincenzo Galluzzo ,&nbsp;Jacopo Gervasoni ,&nbsp;Clara Di Mario ,&nbsp;Luca Santoro ,&nbsp;Barbara Tolusso ,&nbsp;Mariangela Spagnoli ,&nbsp;Alberta Tomassini ,&nbsp;Walter Aureli ,&nbsp;Francesca Toto ,&nbsp;Stefania Pane ,&nbsp;Francesco Landi","doi":"10.1016/j.clnu.2024.11.023","DOIUrl":"10.1016/j.clnu.2024.11.023","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background &amp; aims&lt;/h3&gt;&lt;div&gt;Long-term effects of coronavirus disease 2019 (long COVID) develop in a substantial number of people following an acute COVID-19 episode. Red beetroot juice may have positive effects on multiple pathways involved in long COVID. The aim of this pilot study was to explore the impact of beetroot juice supplementation on physical function, gut microbiota, and systemic inflammation in adults with long COVID.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A single-center, double-blind, placebo-controlled randomized trial was conducted to test the effects of 14 days of beetroot juice supplementation, rich in nitrates and betalains, on functional and biological outcomes in adults aged between 20 and 60 years with long COVID. Participants were randomized 1:1 to receive either daily oral supplementation with 200 mL beetroot juice (∼600 mg nitrate) or placebo (∼60 mg nitrate) for 14 days. The primary endpoint was the change from baseline to day 14 in a fatigue resistance test. Secondary outcomes included the distance walked on the 6-min walk test, handgrip strength, and flow-mediated dilation. Secondary endpoints also included changes from baseline in circulating inflammatory mediators and metagenomic and fecal water metabolomic profiles. Partial least squares discriminant analysis (PLS−DA) models were built to evaluate the differences in biological variables associated with the interventions.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Thirty-one participants were randomized in the study. Twenty-five of them (median (interquartile range) age 40 (10), 14 [56 %] women), received either beetroot juice (15) or placebo (10) and completed the study. At 14 days, fatigue resistance significantly improved from baseline (mean difference [standard error]: +21.8 [3.7] s; &lt;em&gt;p&lt;/em&gt; &lt; 0.001) with no significant differences between intervention groups. A significant increase from baseline in the distance walked on the 6-min walk test was observed (mean difference [standard error]: +30.0 [9.4] m; &lt;em&gt;p&lt;/em&gt; = 0.03), which was not different between groups. Flow-mediated dilation did not differ between participants who received beetroot juice and those on placebo. PLS–DA models allowed correct classification of participants with 92.2 ± 4.4 % accuracy. Those who ingested red beetroot juice had a greater abundance of bacteria with well-known beneficial effects, including &lt;em&gt;Akkermansia&lt;/em&gt;, &lt;em&gt;Oscillospira&lt;/em&gt;, &lt;em&gt;Prevotella&lt;/em&gt;, &lt;em&gt;Roseburia&lt;/em&gt;, &lt;em&gt;Ruminococcaceae&lt;/em&gt;, and &lt;em&gt;Turicibacter&lt;/em&gt;, compared with placebo. Participants allocated to beetroot juice supplementation were also characterized by significantly higher levels of fecal nicotinate, trimethylamine, and markers of beetroot juice intake (e.g., 5,6-dihydroxyindole). Finally, higher levels of interferon gamma and macrophage inflammatory protein-1β were found in participants who consumed beetroot juice.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Beetroot juice supplementation for","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"43 12","pages":"Pages 344-358"},"PeriodicalIF":6.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to the letter to the Editor “ESPEN guideline on nutrition and hydration in dementia - Update 2024” from Barbosa Gomes et al. 回复 Barbosa Gomes 等人写给编辑的信 "ESPEN 痴呆症患者营养与水合指南 - 2024 年更新"。
IF 6.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-14 DOI: 10.1016/j.clnu.2024.11.015
Dorothee Volkert, Anne Marie Beck, Gerd Faxén-Irving, Thomas Frühwald, Lee Hooper, Heather Keller, Judi Porter, Elisabet Rothenberg, Merja Suominen, Rainer Wirth, Michael Chourdakis
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引用次数: 0
Reply - Letter to the editor entitled “Letter to editor regarding Dietary and lifestyle inflammation scores in relation to colorectal cancer recurrence and all-cause mortality: A longitudinal analysis” 回复--致编辑的信,题为 "致编辑的信,关于饮食和生活方式炎症评分与结直肠癌复发和全因死亡率的关系:纵向分析"。
IF 6.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-14 DOI: 10.1016/j.clnu.2024.11.014
Evertine Wesselink, Hendriek C. Boshuizen, Anne-Sophie van Lanen, Dieuwertje E. Kok, Jeroen W.G. Derksen, Karel C. Smit, Johannes H.W. de Wilt, Miriam Koopman, Anne M. May, Ellen Kampman, Fränzel J.B. van Duijnhoven
{"title":"Reply - Letter to the editor entitled “Letter to editor regarding Dietary and lifestyle inflammation scores in relation to colorectal cancer recurrence and all-cause mortality: A longitudinal analysis”","authors":"Evertine Wesselink,&nbsp;Hendriek C. Boshuizen,&nbsp;Anne-Sophie van Lanen,&nbsp;Dieuwertje E. Kok,&nbsp;Jeroen W.G. Derksen,&nbsp;Karel C. Smit,&nbsp;Johannes H.W. de Wilt,&nbsp;Miriam Koopman,&nbsp;Anne M. May,&nbsp;Ellen Kampman,&nbsp;Fränzel J.B. van Duijnhoven","doi":"10.1016/j.clnu.2024.11.014","DOIUrl":"10.1016/j.clnu.2024.11.014","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"44 ","pages":"Pages 5-6"},"PeriodicalIF":6.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global burden of disease attributable to metabolic risk factors in adolescents and young adults aged 15–39, 1990–2021 1990-2021 年全球 15-39 岁青少年和年轻成人代谢风险因素造成的疾病负担。
IF 6.6 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-14 DOI: 10.1016/j.clnu.2024.11.016
Xiao-Dong Zhou , Qin-Fen Chen , Giovanni Targher , Christopher D. Byrne , Christos S. Mantzoros , Huijie Zhang , Amedeo Lonardo , Gregory Y.H. Lip , Gilda Porta , Anoop Misra , Andrew Gerard Robertson , Fei Luo , Anna Alisi , Wah Yang , Mortada El-Shabrawi , Hazem Al Momani , Virend K. Somers , Christos S. Katsouras , Nahum Méndez-Sánchez , Sander Lefere , Ming-Hua Zheng

Background

Metabolic risk factors are a significant cause of global burden among adolescents and young adults, but there is a lack of attention to the burden attributable to these metabolic risk factors globally.

Aims

This study aims to provide comprehensive estimates of five important metabolic risk factors and the attributable disease burden in people aged 15–39 years from 1990 to 2021, based on the Global Burden of Disease Study (GBD) database.

Methods

Global total deaths and disability-adjusted life years (DALYs) were used to describe the burden attributable to five common metabolic risk factors, including high fasting plasma glucose (FPG), high low-density lipoprotein cholesterol (LDL-C), high systolic blood pressure (SBP), high body mass index (BMI), and kidney dysfunction, in adolescents and young adults. The estimated annual percentage changes (EAPC) of DALYs were utilized to depict the trends from 1990 to 2021.

Results

From 1990 to 2021, the DALY rates attributable to all metabolic risk factors showed a globally significant upward trend, with EAPC reaching 33.0 % (27.4–38.7). Compared to females, males had a heavier burden and a more significant increase in deaths and DALYs attributable to metabolic risk factors. High BMI and high FPG have become the top two metabolic risk factors in 2021, with summary exposure variables (SEV) rising by 84.2 % and 53.6 %, respectively. Low-middle socio-demographic index (SDI), middle SDI, and high SDI regions experienced upward regional trends in DALY rates, while low SDI regions remained stable. Among 204 countries and territories, 101 (49.5 %) showed a significant increase in DALY rates, as indicated by the EAPC.

Conclusions

There is a substantial global burden attributable to metabolic risk factors in adolescents and young adults in 2021, especially high BMI and high FPG. This calls for further investigation and intervention to address this emerging trend.
背景:目的:本研究旨在根据全球疾病负担研究(GBD)数据库,对1990年至2021年期间15-39岁人群中的五种重要代谢风险因素和可归因的疾病负担进行全面估算:方法:采用全球总死亡人数和残疾调整生命年数(DALYs)来描述五种常见代谢风险因素对青少年和年轻成年人造成的负担,这五种风险因素包括高空腹血浆葡萄糖(FPG)、高低密度脂蛋白胆固醇(LDL-C)、高收缩压(SBP)、高体重指数(BMI)和肾功能障碍。结果显示,从 1990 年到 2021 年,残疾调整寿命年数的估计年度百分比变化(EAPC)呈上升趋势:结果:从 1990 年到 2021 年,所有代谢风险因素造成的残疾调整寿命年数呈总体显著上升趋势,估计年百分比变化率达到 33.0% (27.4-38.7)。与女性相比,男性的负担更重,代谢风险因素导致的死亡和残疾调整寿命年数的增加也更为显著。高体重指数(BMI)和高血脂指数(FPG)已成为 2021 年的两大代谢风险因素,其暴露变量(SEV)分别上升了 84.2% 和 53.6%。中低社会人口指数(SDI)、中SDI和高SDI地区的残疾调整寿命年率呈上升趋势,而低SDI地区则保持稳定。在 204 个国家和地区中,有 101 个国家和地区(49.5%)的残疾调整寿命年率出现了 EAPC 所显示的显著增长:结论:2021 年,青少年和年轻成年人的代谢风险因素,尤其是高体重指数和高血脂指数,给全球造成了巨大负担。这就需要进一步调查和干预,以应对这一新出现的趋势。
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引用次数: 0
期刊
Clinical nutrition
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