Clinical nutrition最新文献

{"title":"Digital dietary interventions for healthy adolescents: A systematic review of behavior change techniques, engagement strategies, and adherence","authors":"Geiziane Leite Rodrigues Melo ,&nbsp;Rafaela Espírito Santo ,&nbsp;Eugeni Mas Clavel ,&nbsp;Marina Bosque Prous ,&nbsp;Karsten Koehler ,&nbsp;Josep Vidal-Alaball ,&nbsp;Judith van der Waerden ,&nbsp;Inese Gobiņa ,&nbsp;José Francisco López-Gil ,&nbsp;Rodrigo Lima ,&nbsp;Cesar Agostinis-Sobrinho","doi":"10.1016/j.clnu.2025.01.012","DOIUrl":"10.1016/j.clnu.2025.01.012","url":null,"abstract":"<div><h3>Background</h3><div>Adolescence is a crucial phase for developing healthy eating habits with lifelong health implications. Digital interventions, such as smartphone apps and web platforms, have emerged as promising strategies to promote healthy eating habits among adolescents by using behavior change techniques (BCTs). This study aims to systematically review internet-based dietary interventions targeting adolescents, focusing on the analysis of BCTs employed, their delivery modes, and their impact on adolescents' adherence and engagement.</div></div><div><h3>Methods</h3><div>PubMed, Scopus, and Web of Science databases were used up to July 2024. Eligible studies included randomized clinical trials involving adolescents aged 12 to 18. The interventions analyzed involved smartphone apps and web platforms promoting changes in eating habits, with results focusing on adherence and techniques used.</div></div><div><h3>Results</h3><div>The initial search identified 5399 articles, of which 16 studies were included in the final analysis. The studies involved a total of 31,971 participants (range: 29–7890), with 40.29 % being female (n = 12,881), aged 12–18 years. The duration of interventions ranged from two weeks up to 12 months, with follow-ups of up to 24 months. Interventions that utilized BCTs such as goal setting (n = 14), feedback on behavior (n = 14), social support (n = 14), prompts/cues (n = 13), and self-monitoring (n = 12), were the most effective in promoting adherence and engagement. Digital dietary interventions that incorporated personalized feedback (n = 9) and gamification (n = 1) showed adherence rates between 63 % and 85.5 %, with notable improvements in dietary habits, such as increased fruit and vegetable consumption and reduced intake of sugar-sweetened beverages. However, the intervention using gamification involved only 36 participants, and its effects require further investigation due to the limited sample size.</div></div><div><h3>Conclusion</h3><div>Digital interventions show potential for promoting healthy dietary behaviors among adolescents, yet mixed outcomes underscore the challenges of maintaining adherence and long-term engagement. Techniques such as self-monitoring, goal setting, and social support can enhance engagement and effectiveness, particularly when combined with gamified features. The trial protocol is registered on PROSPERO (CRD42024564261).</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 176-192"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Ramadan intermittent fasting on hormones regulating appetite in healthy individuals: A systematic review and meta-analysis","authors":"Deema M. Alogaiel ,&nbsp;Abdulaziz Alsuwaylihi ,&nbsp;May S. Alotaibi ,&nbsp;Ian A. Macdonald ,&nbsp;Dileep N. Lobo","doi":"10.1016/j.clnu.2025.01.005","DOIUrl":"10.1016/j.clnu.2025.01.005","url":null,"abstract":"<div><h3>Background and aims</h3><div>This systematic review and meta-analysis aimed to examine the effect of Ramadan intermittent fasting on appetite-regulating hormones including leptin, ghrelin, insulin, gastrin, glucagon-like peptide-1, peptide YY, and cholecystokinin.</div></div><div><h3>Methods</h3><div>We searched the MEDLINE, Embase, Cochrane Library, CINAHL, Google Scholar, and Web of Science databases to identify relevant research on appetite-regulating hormones during Ramadan intermittent fasting, published until the end of March 2024.</div></div><div><h3>Results</h3><div>Data from 16 eligible studies comprising 664 participants (341, 51.4 % male) with a mean ± standard deviation age of 33.9 ± 10.8 years were included. The meta-analysis included 12 studies with complete leptin data, showing no significant effect of Ramadan intermittent fasting on leptin concentrations (standardised mean difference – SMD = −0.11 μg/mL, 95 % CI: −0.36 to 0.14). Analysis of three studies with complete ghrelin data demonstrated a significant increase in ghrelin concentrations following Ramadan intermittent fasting (SMD = 0.31 pg/mL, 95 % CI: 0.03 to 0.60). Six studies examining insulin concentrations pre- and post-fasting revealed no significant effect on insulin concentrations (SMD = −0.24 μU/mL, 95 % CI: −0.54 to 0.02). Similarly, analysis of three studies with complete gastrin data showed no significant effect of intermittent fasting on gastrin concentrations (SMD = 0.23 pg/mL, 95 % CI: −0.71 to 0.99).</div></div><div><h3>Conclusion</h3><div>Ramadan intermittent fasting significantly increases ghrelin concentrations while showing no significant effects on leptin, insulin, and gastrin. While ghrelin findings were consistent across studies, the high heterogeneity in leptin studies suggests further research to better understand the effects of Ramadan intermittent fasting on appetite-regulating hormones.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 250-261"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Dietary patterns, inflammatory biomarkers and cognition in older adults: An analysis of three population-based cohorts” [Clin Nutr 10 (43) (2024) 2336-2343]","authors":"Natalia Ortega ,&nbsp;Leona Schütte ,&nbsp;Tosca O.E. de Crom ,&nbsp;Trudy Voortman ,&nbsp;Olivia I. Okereke ,&nbsp;Marco Vinceti ,&nbsp;Armin von Gunten ,&nbsp;Pedro Marques-Vidal ,&nbsp;Nicolas Rodondi ,&nbsp;Arnaud Chiolero ,&nbsp;Patricia O. Chocano-Bedoya","doi":"10.1016/j.clnu.2025.01.013","DOIUrl":"10.1016/j.clnu.2025.01.013","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 134-135"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low maternal iodine intake and subsequent risk of pharmacologically treated hypertension: A population-based prospective cohort study","authors":"Mari Bergflødt Wikerholmen ,&nbsp;Hanne Rosendahl-Riise ,&nbsp;Kristin Øksendal Børresen ,&nbsp;Teresa Risan Haugsgjerd ,&nbsp;Eva Gerdts ,&nbsp;Anne Lise Brantsæter","doi":"10.1016/j.clnu.2025.01.001","DOIUrl":"10.1016/j.clnu.2025.01.001","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Iodine deficiency is linked to multiple adverse health outcomes, but there is scarce knowledge regarding iodine intake and development of chronic hypertension. We aimed to investigate the prospective association between habitual dietary iodine intake and pharmacologically treated hypertension in mothers up to 10 years after delivery.</div></div><div><h3>Methods</h3><div>The present study is based on data from an ongoing pregnancy cohort and includes 58,629 women without thyroid dysfunction and hypertension at baseline. The study outcome was new-onset hypertension defined according to antihypertensive medication use initiated 90 days after delivery registered in the national prescription database. We estimated hazard ratios (HR) with 95 % Confidence Intervals (95 % CI) using Cox regression models.</div></div><div><h3>Results</h3><div>During a median follow-up duration of 7.1 years, a total of 1422 (2.4 %) women developed new-onset hypertension. There was a non-linear association between dietary iodine intake and new-onset hypertension. Women with iodine intakes lower than 100 μg/day had significantly higher risk than those with iodine intakes in the recommended range 150–199 μg/day (adjusted HR, 1.29; 95 % CI: 1.09, 1.53). This was evident in normotensive pregnancies (adjusted HR 1.25; 95 % CI: 1.01, 1.54) and in women with gestational hypertension (adjusted HR 1.35; 95 % CI: 1.00, 1.83). The association between low iodine intake and hypertension remained in all sensitivity analyses considering pre-pregnancy and pregnancy-related factors.</div></div><div><h3>Conclusions</h3><div>This study suggests that women with iodine intakes below 100 μg/day have a higher likelihood of new-onset hypertension and adds supporting evidence to the importance of correcting mild-to-moderate iodine deficiency in women of reproductive age.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 148-155"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-based dietary patterns, nutrient intake, growth, and body composition in childhood: Results from a prospective population-based study","authors":"Hong Sun ,&nbsp;Marinka Steur ,&nbsp;Yuchan Mou ,&nbsp;Trudy Voortman","doi":"10.1016/j.clnu.2025.01.010","DOIUrl":"10.1016/j.clnu.2025.01.010","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Transitioning to more plant-based diets promotes environmental sustainability and has health benefits for adults. However, associations with nutrient intake adequacy and growth in children remain unknown. This study aimed to examine associations of plant-based diets with nutrient intake levels among children, and with longitudinal growth and body composition up to adolescence.</div></div><div><h3>Method</h3><div>We included 3340 children in the Generation R Study, a population-based cohort. Food and nutrient intake were assessed at the age of 8 years, and anthropometrics and body composition (using dual-energy X-ray absorptiometry) were measured at the ages of 10 and 13 years. Plant-based diets were quantified using three plant-based diet indices (PDIs): overall plant-based diet index (PDI), healthful PDI (hPDI), and unhealthful PDI (uPDI). Modified Poisson regression and linear mixed models were used to estimate the associations of PDIs with nutrient intake levels, and with sex- and age-standardized measures of anthropometrics and body composition.</div></div><div><h3>Results</h3><div>Higher scores on each of the three PDIs were associated with lower intake of vitamin B2, B12, and calcium, while higher hPDI score was associated with higher intake levels of fiber, vitamin C, magnesium, and copper. Higher hPDI score was also associated with higher fat-free mass index (FFMI) z-score (0.05 per 10-hPDI score increment, 95 % CI: 0.01, 0.10), and with lower body fat percentage z-score (−0.05, 95 % CI: −0.09, −0.01), while higher uPDI score was associated with lower height, weight, and FFMI z-score (FFMI: −0.08, 95 % CI: −0.12, −0.03) up to age of 13 years.</div></div><div><h3>Conclusions</h3><div>In this cohort study, higher adherence to healthful plant-based diets, rather than unhealthful ones, was associated with better nutrient intakes, and subsequent healthy body composition throughout childhood to adolescence. Our findings suggest that consuming healthful plant-based foods may contribute to children's diets' nutrient quality and subsequent body composition. Still, attention should be given to ensuring balanced and adequate nutrient intake for optimal plant-based eating.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 202-211"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor–The potential of body mass index-adjusted calf circumference as a proxy for low muscle mass in the global leadership initiative on malnutrition criteria","authors":"Okan Turhan,&nbsp;Mert Eşme,&nbsp;Cafer Balcı","doi":"10.1016/j.clnu.2025.01.031","DOIUrl":"10.1016/j.clnu.2025.01.031","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"46 ","pages":"Pages 131-132"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143261917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor–Beetroot juice intake positively influenced gut microbiota and inflammation but failed to improve functional outcomes in adults with Long COVID","authors":"Yoshiyasu Takefuji","doi":"10.1016/j.clnu.2025.01.027","DOIUrl":"10.1016/j.clnu.2025.01.027","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"46 ","pages":"Pages 117-118"},"PeriodicalIF":6.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply - Letter to the editor - Comment on “Ultra-processed foods and liver cancer risk: A call for further investigation\"","authors":"Longgang Zhao,&nbsp;Xuehong Zhang","doi":"10.1016/j.clnu.2025.01.024","DOIUrl":"10.1016/j.clnu.2025.01.024","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"46 ","pages":"Page 136"},"PeriodicalIF":6.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143348080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein supplementation differentially alters gut microbiota and associated liver injury recovery in mouse model of alcohol-related liver disease","authors":"Ashi Mittal ,&nbsp;Nishu Choudhary ,&nbsp;Anupama Kumari ,&nbsp;Kavita Yadav ,&nbsp;Jaswinder Singh Maras ,&nbsp;Shiv K. Sarin ,&nbsp;Shvetank Sharma","doi":"10.1016/j.clnu.2025.01.022","DOIUrl":"10.1016/j.clnu.2025.01.022","url":null,"abstract":"<div><h3>Background</h3><div>Patients with Alcohol-related Liver Disease (ALD) are advised increased protein supplementation. These nutrients are also available to gut microbiota. We evaluated the effects of protein supplementation from two sources, soya (veg) or egg, on gut microbiota modulation and ALD remission.</div></div><div><h3>Methods</h3><div>ALD was induced in mice using the Lieber-DeCarli diet and incremental ethanol + thioacetamide (150 mg/kg body-weight,i.p.) twice-a-week. After 8wks, mice were fed standard (std.), egg (ovalbumin) or veg diet (20 % increase protein) for 7days. Biochemical parameters, hepatic proteome and gut microbiota composition were analyzed and correlated to capture liver and intestinal recovery.</div></div><div><h3>Results</h3><div>Veg-diet decreased hepatic steatosis and fibrosis compared with std diet (83.3 %, p = 0.001 and 75 %, p = 0.01, respectively) or egg-diet (66.6 %, p = 0.03 and 25 %, p = 0.04, respectively). ALT and AST levels reduced by 40 % (p = 0.04) and 27.3 % (p = 0.04), respectively in veg diet compared to egg diet. Veg-diet increased intestinal claudin-3 (61 %, p = 0.02) and occludin (80 %, p = 0.001) compared to egg-diet. Plasma endotoxin levels in veg were reduced by 64 % and 32 % compared to std. (p = 0.04) or egg (p = 0.06). Veg-diet increased beneficial taxa, <em>Lachnospiraceae UCG-006</em> (8.06-folds, p = 1.64E-25), <em>Prevotellaceae</em> NK3B31 (9.96-folds, p = 1.58E-36), <em>Kurthia</em> (8.11-folds, p = 3.98E-16) and <em>Akkermansia</em> (5.9-folds, p = 5.01E-75), while decreasing pathogenic <em>Roseburia</em> (−3.28-folds, p = 1.60E-06), <em>Klebsiella</em> (−5.7-folds, p = 1.55E-06), <em>Staphylococcus</em> (−5.3-folds, p = 1.62E-12). Hepatic proteome showed an increase in pyruvate, cysteine, methionine metabolism, bile acid biosynthesis, and glycolysis.</div></div><div><h3>Conclusion</h3><div>Alteration in protein alone can affect variable outcomes in ALD, with protein from vegetable sources resulting in enhanced improvement in the gut–liver axis. Vegetable protein-supplemented diet enhances fatty acid beta oxidation and energy metabolism accompanied by improvement in gut-dysbiosis and ALD associated hepatic injury.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"46 ","pages":"Pages 96-106"},"PeriodicalIF":6.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic anticoagulation in children receiving home parenteral nutrition: An international prospective multicenter study","authors":"Aysenur Demirok ,&nbsp;Sjoerd C.J. Nagelkerke ,&nbsp;Samantha C. Gouw ,&nbsp;Barbara A.E. de Koning ,&nbsp;C. Heleen van Ommen ,&nbsp;Rozemarijn Duister ,&nbsp;Marc A. Benninga ,&nbsp;Cécile Lambe ,&nbsp;Merit M. Tabbers","doi":"10.1016/j.clnu.2025.01.023","DOIUrl":"10.1016/j.clnu.2025.01.023","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Catheter-related thrombosis (CRT) is a serious complication associated with home parenteral nutrition (HPN) in children with chronic intestinal failure (CIF). Guidelines on pediatric HPN state that there is insufficient evidence to advocate the prophylactic use of CRT. Aim is to evaluate the efficacy and safety of prophylactic anticoagulation in preventing CRT in children on HPN.</div></div><div><h3>Methods</h3><div>We performed a prospective, international, multicenter study across three expertise centers. Children aged 0–18 years on HPN were included and divided into two groups: 1) primary/secondary prophylaxis- and 2) non-prophylaxis group. Participants were followed for 24 months and screened for CRT using ultrasonography annually. Primary outcomes included total incidence of CRT per 1000 catheter days, and association between prophylactic anticoagulation and CRT. Propensity score stratification and logistic regression were used to evaluate the association between prophylactic anticoagulation and CRT, adjusting for significant covariates differing between groups. Balance was visually assessed before and after stratification, and statistical significance (p &lt; 0.05) was determined. Secondary outcomes included incidence of catheter-related bloodstream infections (CRBSI) and bleeding events per 1000 catheter days.</div></div><div><h3>Results</h3><div>A total of 115 children, mean age of 6,9 years (SD 4,6), were included. Fifty-seven patients were receiving prophylactic anticoagulation (50 %). The overall incidence of CRT was 0.17 per 1000 catheter days in 13 patients (11 %), with no significant difference between the prophylaxis (n = 6) and non-prophylaxis group (n = 7) (odds ratio 0.64, 95 % CI: 0.12–3.4, <em>p</em> = 0.60). Incidence rate of CRBSIs was 0.34/1000 catheter days (n = 25). Patients with CRT during follow up were significantly more likely to have a CRBSI (54 %) compared to those without (14 %) (p = 0.010). Two minor bleeding events were reported in the prophylaxis group, resulting in an incidence of 0,03/1000 catheter days.</div></div><div><h3>Conclusions</h3><div>Our study shows that prophylactic anticoagulation does not significantly reduce the incidence of CRT in children on HPN. Our results do underline the clinical importance of optimal catheter care and infection prevention as CRBSIs were more likely to occur in patients with CRT, and emphasize the need for larger multicenter trials to establish evidence-based recommendations for the use of prophylactic anticoagulation in children on HPN.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"46 ","pages":"Pages 88-95"},"PeriodicalIF":6.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}