Clinical nutrition最新文献

{"title":"Development and validation of the Crohn's disease-intestinal failure-wean (CDIF-Wean) Score to predict outcomes of intestinal rehabilitation","authors":"Tian Hong Wu ,&nbsp;Thomas Scheike ,&nbsp;Christopher Filtenborg Brandt ,&nbsp;Maja Kopczynska ,&nbsp;Michael Taylor ,&nbsp;Simon Lal ,&nbsp;Palle Bekker Jeppesen","doi":"10.1016/j.clnu.2024.12.025","DOIUrl":"10.1016/j.clnu.2024.12.025","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Enteral autonomy, a key outcome of intestinal rehabilitation in patients with intestinal failure (IF), is challenging to predict due to disease complexity and heterogeneity. The aim of this cohort study is to develop and validate a multivariate model to predict enteral autonomy in patients with IF caused by Crohn's disease (CDIF), and to derive an outcome-based severity classification for CDIF.</div></div><div><h3>Methods</h3><div>The CDIF-Wean Score was constructed and internally validated in a cohort of 182 patients with CDIF from a tertiary IF unit. We performed stepwise backward selection to include relevant and significant clinical variables in a binomial regression with inverted probability of censoring weighting. The Score was externally validated in a separate cohort of 107 patients with CDIF from an independent tertiary IF unit. A severity classification, based on the CDIF-Wean Score, was evaluated with cumulative incidence curves for enteral autonomy and death during home parenteral support (HPS).</div></div><div><h3>Results</h3><div>In the CDIF-Wean Score, age, HPS duration, chronicity of Crohn's disease, intestinal anatomy, and eligibility and type of reconstructive surgery was predictive of enteral autonomy. The Score performed well in discrimination and calibration, with 0.84 and 0.84 area under the receiver operating characteristic curve, and 0.13 and 0.16 Brier scores in internal and external validation, respectively. The CDIF severity classification was significantly associated with both short- and long-term prognosis, where mild patients had a 7.5, 5.8 and 5.2-fold higher probability of enteral autonomy than severe patients at 1, 5 and 10 years <em>(p&lt;0.0001)</em>.</div></div><div><h3>Conclusion</h3><div>The CDIF-Wean Score is the first validated prediction model for IF outcomes, and demonstrates accuracy, robustness and generalisability in the prognostication of CDIF patients.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 66-74"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply - Letter to the editor - ‘Beetroot juice intake positively influenced gut microbiota and inflammation but failed to improve functional outcomes in adults with Long COVID’","authors":"Riccardo Calvani,&nbsp;Emanuele Marzetti,&nbsp;Matteo Tosato,&nbsp;Ottavia Giampaoli,&nbsp;Michele De Rosa,&nbsp;Federico Marini","doi":"10.1016/j.clnu.2025.01.033","DOIUrl":"10.1016/j.clnu.2025.01.033","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"46 ","pages":"Pages 133-135"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143202687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simplified multidimensional scale approach is effective in predicting mortality in hospitalized older adults and highlights the role of nutrition","authors":"Gianluca Gortan Cappellari ,&nbsp;Marta Calcagnile ,&nbsp;Renata Pennisi ,&nbsp;Giuseppe Castiglia ,&nbsp;Emanuele Concollato ,&nbsp;Gianfranco Sanson ,&nbsp;Rocco Barazzoni ,&nbsp;Paolo De Colle ,&nbsp;Michela Zanetti","doi":"10.1016/j.clnu.2024.12.015","DOIUrl":"10.1016/j.clnu.2024.12.015","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background &amp; aims&lt;/h3&gt;&lt;div&gt;Malnutrition and cognitive impairment are among the major contributors to frailty, that significantly increases the risk of mortality of older hospitalized patients. Multidimensional frailty assessment tools, such as the multidimensional prognostic index-MPI, a tool based on a standard comprehensive geriatric assessment (CGA), have proven valuable for predicting adverse outcomes, including mortality of older adults following acute illness but its application in everyday clinical practice is limited. We hypothesized that removing parameters not closely associated with mortality and sorting the patient population according to the presence or not of cognitive impairment with possible integration of common laboratory markers, could provide a simplified approach that could improve practicability in all settings with at least comparable 1-year mortality predictive value.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A retrospective cohort study was conducted in patients consecutively admitted to the Geriatric Clinic of the Maggiore University Hospital in Trieste, Italy from January 1st 2018 to December 31st 2019. Their demographics, functional, clinical, laboratory parameters and 1-year mortality were recorded. In a development cohort of 1032 consecutive patients, best predictors of mortality were selected via systematic analysis and included in simplified prognostic models and algorithms and subsequently compared for prediction of 1-year mortality. The predictive relevance of the best algorithms was then validated, in comparison to MPI, in a separate cohort of 575 consecutive patients.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;While all demographic and tested laboratory parameters as well as MPI domains correlated with 1-year mortality, exclusion from MPI calculation of Short Portable Mental Status Questionnaire (SPSMQ), Exton Smith scale (ESS) and Mini Nutritional Assessment (MNA) significantly reduced MPI mortality predictivity, suggesting that not all MPI domains have the same weight. Further analysis showed that in the whole study cohort and in subgroups according to cognitive function, selected models including up to 3 parameters were superior to MPI in predicting 1-year mortality. In particular, models including MNA and albumin, or Exton Smith scale proved to better predict mortality in patients without or with severe cognitive impairment, respectively. A derived diagnostic algorithm applying different models according to cognitive status showed improved predictive value compared to MPI while requiring shorter estimated assessment time. Internal validation confirmed these results [HR: 4.37 (3.02–6.31) vs 3.16 (2.18–4.61), &lt;em&gt;p&lt;/em&gt; &lt; 0.0001].&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;In older acutely ill patients, a simplified multidimensional algorithm approach based on the assessment of cognitive function followed by nutritional status with the addition of plasma albumin or of functional status in patients without ","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 1-9"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of creatinine-to-cystatin C ratio with computed tomography measures of skeletal muscle quantity and quality: The multi-ethnic study of atherosclerosis","authors":"Saeid Mirzai ,&nbsp;Michael P. Bancks ,&nbsp;Tina E. Brinkley ,&nbsp;Salvatore Carbone ,&nbsp;W. H. Wilson Tang ,&nbsp;Matthew A. Allison ,&nbsp;Michael D. Shapiro","doi":"10.1016/j.clnu.2024.12.026","DOIUrl":"10.1016/j.clnu.2024.12.026","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Skeletal muscle (SM) health has significant prognostic value in geriatric and chronic disease populations, yet its assessment is frequently omitted due to challenges in evaluation. The creatinine-to-cystatin C ratio (CCR) is a simple serum-based measure that associates well with measured SM quantity (myopenia) and strength, but evidence for its association with SM quality (myosteatosis) is limited and conflicting. This study investigated the association between CCR and computed tomography (CT) measures of myopenia and myosteatosis.</div></div><div><h3>Methods</h3><div>In this cross-sectional analysis of the Multi-Ethnic Study of Atherosclerosis, 1035 participants with complete body composition measurements and visit-matched serum creatinine and cystatin C measurements were included. CCR was calculated as (serum creatinine/serum cystatin C) x 100. Myopenia was quantified as SM index (SMI; SM area normalized for body surface area) and myosteatosis as SM density (SMD; based on Hounsfield units) from CT images. Correlation analyses and multivariable linear regression were used to model the relationships of CCR with SMI and SMD.</div></div><div><h3>Results</h3><div>CCR was positively correlated and associated with SMI (rho = 0.295, p &lt; 0.001; adjusted β 0.071 per 1 % increase in CCR, standard error [SE] 0.032, 95 % confidence interval [CI] 0.009 to 0.133, p = 0.026) and SMD (rho = 0.417, p &lt; 0.001; adjusted β 0.040 per 1 % increase in CCR, SE 0.006, 95 % CI 0.027 to 0.052, p &lt; 0.001). However, the associations were weaker in participants with chronic kidney disease (CKD), particularly for SMD (interaction p = 0.005).</div></div><div><h3>Conclusions</h3><div>CCR is associated with CT measures of myopenia and myosteatosis; however, it should be used cautiously in patients with CKD.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 61-65"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are enteral devices risk factors for central line-associated bloodstream infections in children with intestinal failure?","authors":"D. Gattini ,&nbsp;A. Murphy ,&nbsp;C. Belza ,&nbsp;Y. Avitzur ,&nbsp;P.W. Wales","doi":"10.1016/j.clnu.2024.12.014","DOIUrl":"10.1016/j.clnu.2024.12.014","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Central line-associated bloodstream infections (CLABSI) represent one of the most common and serious complications in children with intestinal failure (IF). This study aimed to assess if there is an association between the use of enteral devices (feeding tubes and stomas) with rate of CLABSI after adjusting for clinically relevant factors. Second, association between enteral devices with time to first CLABSI event was evaluated.</div></div><div><h3>Methods</h3><div>Retrospective cohort of 202 children with IF and home parenteral nutrition treated at The Hospital for Sick Children between January 2006, and December 2017, with a minimum of 12 months of follow-up. Negative binomial multivariable regression model was used to assess factors associated with rate of CLABSI. Cox proportional hazard regression model was used to assess factors associated with time to first CLABSI event.</div></div><div><h3>Results</h3><div>The use of feeding tubes [RR 1.10 (95%CI 0.88–1.37); <em>p</em> = 0.407] or stomas [RR 1.00 (95%CI 0.82–1.22); <em>p</em> = 0.974] was not associated with rate of CLABSI after adjusting for confounding factors. There was a significant association between history of prematurity [RR 1.36 (95%CI 1.09–1.70); <em>p</em> = 0.007], male sex [RR 1.28 (95%CI 1.05–1.56); <em>p</em> = 0.016], age at diagnosis of intestinal failure &lt;1 year [RR 2.41 (95%CI 1.75–3.33); <em>p</em> &lt; 0.001], having &lt;50 % of small bowel length expected for age [RR 2.39 (95%CI 1.87–3.05); <em>P</em> &lt; 0.001], and small bowel bacterial overgrowth (SBBO) [RR 1.38 (95%CI 1.10–1.74); <em>p</em> = 0.006], with rate of CLABSI events after multivariable analysis. The use of feeding tubes [HR 0.79 (95%CI 0.49–1.26); <em>p</em> = 0.315] or stomas [HR 1.25 (95%CI 0.81–1.94); <em>p</em> = 0.308] was not associated with time to first CLASBSI episode after multivariable regression analysis. Only length of small bowel &lt;50 % was associated with time to first CLABSI event on multivariable analysis [HR 1.83 (95%CI 1.14–2.93); <em>p</em> = 0.012].</div></div><div><h3>Conclusion</h3><div>Feeding tubes and stomas were not associated with increased rate of CLABSI or time to first CLABSI episode. However, prematurity, male sex, age at diagnosis of intestinal failure &lt;1 year, having &lt;50 % of small bowel length expected for age, and SBBO were associated with rate of CLABSI events; and having &lt;50 % of small bowel length was associated with time to first CLABSI event. Prospective, multicenter studies accounting for care delivery and prevention bundles are needed to identify patients that would benefit from additional interventions to prevent CLABSI.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 75-80"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Effects of early nutritional intervention on oral mucositis and basic conditions in patients receiving radiotherapy for head and neck cancer: Randomized controlled trial”","authors":"Qing Liu ,&nbsp;Ye Jiang ,&nbsp;Dan Wang","doi":"10.1016/j.clnu.2025.01.006","DOIUrl":"10.1016/j.clnu.2025.01.006","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 165-166"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between C-reactive protein-albumin-lymphocyte index and overall survival in patients with esophageal cancer","authors":"Pingping Jia ,&nbsp;Fangqi Shen ,&nbsp;Qianqian Zhao ,&nbsp;Xiaoxiao Wu ,&nbsp;Kai Sun ,&nbsp;Xiaolin Wang ,&nbsp;Guangzhong Xu ,&nbsp;Hongxia Xu ,&nbsp;Minghua Cong ,&nbsp;Chunhua Song ,&nbsp;Hanping Shi","doi":"10.1016/j.clnu.2024.12.032","DOIUrl":"10.1016/j.clnu.2024.12.032","url":null,"abstract":"<div><h3>Background</h3><div>Esophageal cancer is an aggressive malignant tumor with poor prognosis, making early detection and treatment crucial. C-reactive protein-albumin-lymphocyte (CALLY) index is a comprehensive indicator which is involved in the process of metabolism, inflammation and immune reaction, and has been addressed to correlate with clinical outcomes in cancer patients. However, However, the evidence in esophageal cancer remains unclear. This study aims to investigate the association between CALLY index and overall survival of patients with esophageal cancer.</div></div><div><h3>Methods</h3><div>This study includes the clinical characteristics of 518 patients with esophageal cancer from the Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) project, and evaluates the correlation between CALLY index and overall survival by COX regression analysis. Time-patient survival trends are verified using Kaplan–Meier method, and cubic spline function. Based on the results of multivariate Cox analysis, a nomogram showing 1, 2, 3, and 5-year survival rates is constructed. Calibration curve and decision curve analysis are used to evaluate the prediction accuracy and practical value of nomogram survival prediction. TNM staging of patients with esophageal cancer is determined according to the pathological examination results of the tumor and surrounding tissues, including the size and depth of the tumor (T), the involvement of lymph nodes (N), and the distant metastasis (M).</div></div><div><h3>Results</h3><div>Multivariate Cox regression analysis demonstrates that CALLY index (HR:0.967, 0.937–0.997, <em>P</em> &lt; 0.05), smoking (HR: 1.592, 1.064–2.380, <em>P</em> &lt; 0.05), TNM staging (HR: 1.595, 1.120–2.270, <em>P</em> &lt; 0.05) are independent prognostic factors for survival of patients with esophageal cancer. Patients with high CALLY index has the lower risk of death than those with low CALLY index (HR: 0.54, 0.36–0.80, <em>P</em> &lt; 0.05). The nomogram model including CALLY index shows better prediction ability than traditional TNM staging system.</div></div><div><h3>Conclusion</h3><div>CALLY index is independently positive associated with overall survival in patients with esophageal cancer and nomogram model displays superiority over TMN staging in predicting overall survival.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 212-222"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor - A multicenter randomized controlled trial comparing three-times-a-day intermittent enteral postural feeding to continuous enteral feeding among mechanically ventilated patients in intensive care","authors":"Yuying Chi ,&nbsp;Yuan Ji ,&nbsp;Mingxian Chen","doi":"10.1016/j.clnu.2025.01.011","DOIUrl":"10.1016/j.clnu.2025.01.011","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 174-175"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1-phenyl-3-methyl-5-pyrazolone activates the AMPK pathway to alleviate western-diet induced metabolic dysfunction-associated steatohepatitis in mice","authors":"Xiaoning Chen ,&nbsp;Jiaofeng Huang ,&nbsp;Yanying You ,&nbsp;Hanxin Xue ,&nbsp;Lisha Wu ,&nbsp;Danyi Zeng ,&nbsp;Qingqing Xing ,&nbsp;Minxia Wu ,&nbsp;Mingfang Wang ,&nbsp;Jinshui Pan ,&nbsp;Su Lin ,&nbsp;Yueyong Zhu","doi":"10.1016/j.clnu.2024.12.033","DOIUrl":"10.1016/j.clnu.2024.12.033","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Approved drugs for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) are limited, although it has become the most common chronic liver disease worldwide. 1-phenyl-3-methyl-5-pyrazolone (PMP) possesses various biological effects such as anti-inflammatory and antioxidant. However, the effects and underlying mechanism of PMP in MASH remain unclear.</div></div><div><h3>Methods</h3><div>Steatosis cells were induced by palmitate/oleic acid (PO). Then, the contents of lipids and reactive oxygen species were measured. To further investigate the effects of PMP on MASH models, C57BL/6J mice were fed a western diet (WD) for 24 weeks and PMP was administered daily by intragastric gavage. Serum enzymes and lipids were assayed by a biochemistry analyzer. RNA sequencing, real-time qPCR, and western blotting were used to measure the expression of different genes. Histological analysis of the liver included HE, Oil red O, and Sirius red staining.</div></div><div><h3>Results</h3><div>PMP alleviated lipid accumulation and oxidative stress induced by PO (<em>P</em> &lt; 0.001). In vivo, WD-induced significant elevation of blood glucose and serum lipids were reduced by PMP (<em>P</em> &lt; 0.05). Furthermore, PMP effectively prevented hepatic steatosis, inflammation, and fibrosis in MASH mice. Western blot results suggested PMP promoted the phosphorylation of LKB1 and AMPKα at T172, which is a marker of activation of the AMPK pathway. RNA sequencing also demonstrated that PMP facilitated the activation of the AMPK pathway. Furthermore, the protective effects of PMP on steatosis cells and MASH mice disappeared after treatment with an AMPK inhibitor.</div></div><div><h3>Conclusions</h3><div>PMP protects against metabolic-stress-induced MASH through activating AMPK signaling, indicating that PMP may be a candidate for MASH therapy in the future.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 136-147"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional interventions in depression: The role of vitamin D and omega-3 fatty acids in neuropsychiatric health","authors":"Muhammad Liaquat Raza ,&nbsp;Syed Tawassul Hassan ,&nbsp;Subia Jamil ,&nbsp;Wajiha Fatima ,&nbsp;Madiha Fatima","doi":"10.1016/j.clnu.2025.01.009","DOIUrl":"10.1016/j.clnu.2025.01.009","url":null,"abstract":"<div><h3>Background</h3><div>Depression is a pervasive mental health disorder with complex etiologies involving neurotransmitter imbalances, inflammation, and hormonal dysregulation. Emerging evidence highlights the significance of nutritional interventions in improving depressive symptoms.</div></div><div><h3>Objective</h3><div>This review explores the mechanisms of action and clinical applications of Vitamin D and Omega-3 fatty acids in managing depression, providing insights into their potential therapeutic roles.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted across databases, including PubMed, Scopus, Web of Science, and PsycINFO. Keywords such as “depression,” “Vitamin D,” “Omega-3 fatty acids,” “nutritional psychiatry,” and “mental health” were employed. Articles were selected based on relevance, methodology, and contribution to the understanding of nutritional interventions in depression. Observational studies, randomized controlled trials, and meta-analyses were prioritized, while non-peer-reviewed sources were excluded.</div></div><div><h3>Results</h3><div>Vitamin D modulates neurotransmitter activity, reduces neuroinflammation, and influences neuroplasticity, enhancing cognitive function and mood regulation. Omega-3 fatty acids, particularly EPA and DHA, exhibit anti-inflammatory properties, optimize serotonergic transmission, and stabilize neuronal membranes. Clinical evidence suggests that supplementation with these nutrients can significantly reduce depressive symptoms, particularly in patients with comorbid nutritional deficiencies. However, variability in study designs and dosages limits the generalizability of findings.</div></div><div><h3>Conclusion</h3><div>Integrating Vitamin D and Omega-3 supplementation into mental health care holds promise as an adjunctive strategy for treating depression. However, limitations in existing studies, including heterogeneity in study design and dosage, warrant further investigation.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"45 ","pages":"Pages 270-280"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}