Clinical nutrition最新文献

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Reply to the letter to the editor about “Geriatrician perspective on the malnutrition and long-term mortality in hospitalized older adults” by Okyar Baş and Balcı 回复 Okyar Baş 和 Balcı 就 "老年病学家对住院老年人营养不良和长期死亡率的看法 "写给编辑的信。

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition

Pub Date : 2024-10-05 DOI: 10.1016/j.clnu.2024.10.002

引用次数: 0

Letter to the editor - “Mediterranean ketogenic diet accounts for reduced pain frequency and intensity in patients with chronic migraine: A pilot study” 致编辑的信--"地中海生酮饮食可降低慢性偏头痛患者的疼痛频率和强度：一项试点研究"

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition

Pub Date : 2024-10-05 DOI: 10.1016/j.clnu.2024.10.005

引用次数: 0

Low serum glycine strengthens the association between branched-chain amino acids and impaired insulin sensitivity assessed before and after weight loss in a population with pre-diabetes: The PREVIEW_NZ cohort 在糖尿病前期人群中，低血清甘氨酸加强了支链氨基酸与减肥前后胰岛素敏感性受损之间的联系：PREVIEW_NZ 队列

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition

Pub Date : 2024-10-02 DOI: 10.1016/j.clnu.2024.09.047

Aim

Accumulation of circulating branched-chain amino acids (BCAA) is a hallmark feature of impaired insulin sensitivity. As intracellular BCAA catabolism is dependent on glycine availability, we hypothesised that the concurrent measurement of circulating glycine and BCAA may yield a stronger association with markers of insulin sensitivity than either BCAA or glycine alone. This study therefore examined the correlative relationships of BCAA, BCAA and glycine together, plus glycine alone on insulin sensitivity-related markers before and after an 8-week low energy diet (LED) intervention.

Methods

This is a secondary analysis of the PREVIEW (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World) Study New Zealand sub-cohort. Eligible participants with pre-diabetes at baseline who achieved ≥8 % body weight loss following an LED intervention were included, of which 167 paired (Week 0 and Week 8) blood samples were available for amino acid analysis. Glycemic and other data were retrieved from the PREVIEW consortium database. Repeated measures linear mixed models were used to test the association between amino acids and insulin sensitivity-related markers (HOMA2-IR, glucose, insulin, and C-peptide).

Results

Elevated BCAA was associated with impaired insulin sensitivity (p < 0.05), with strength of association (ηp2) almost doubled when glycine was added to the model. However, glycine in isolation was not associated with insulin sensitivity-related markers. The magnitude (β-estimates) of positive association between BCAA and HOMA2-IR, and inverse association between glycine and HOMA2-IR, increased when body weight was higher (Body weight∗BCAA, Body weight∗glycine, p < 0.05, both).

Conclusion

Low serum glycine strengthened the association between BCAA and impaired insulin sensitivity. Given that glycine is necessary to facilitate intracellular BCAA catabolism, measurement of glycine is necessary to complement BCAA analysis to comprehensively understand the contribution of amino acid metabolism in insulin sensitivity.

Clinical trial registration

This study was registered with ClinicalTrials.gov (NCT01777893).

目的循环支链氨基酸（BCAA）的积累是胰岛素敏感性受损的一个标志性特征。由于细胞内 BCAA 的分解代谢依赖于甘氨酸的供应，我们假设同时测量循环中的甘氨酸和 BCAA 可能比单独测量 BCAA 或甘氨酸与胰岛素敏感性指标有更强的关联。因此，本研究考察了在为期 8 周的低能量饮食（LED）干预前后，BCAA、BCAA 和甘氨酸共同与单独甘氨酸对胰岛素敏感性相关指标的相关关系。方法这是 PREVIEW（在欧洲和世界各地通过生活方式干预和人口研究预防糖尿病）研究新西兰子队列的二次分析。研究纳入了基线值为糖尿病前期、在接受 LED 干预后体重减轻≥8% 的合格参与者，其中 167 份配对（第 0 周和第 8 周）血液样本可用于氨基酸分析。血糖和其他数据均来自 PREVIEW 联合数据库。采用重复测量线性混合模型检验氨基酸与胰岛素敏感性相关指标（HOMA2-IR、葡萄糖、胰岛素和 C 肽）之间的关联。结果BCAA升高与胰岛素敏感性受损有关（p <0.05），当甘氨酸加入模型时，关联强度（ηp2）几乎翻倍。然而，单独的甘氨酸与胰岛素敏感性相关指标无关。当体重较高时，BCAA 与 HOMA2-IR 之间正相关的程度（β-估计值）以及甘氨酸与 HOMA2-IR 之间反相关的程度（体重∗BCAA，体重∗甘氨酸，两者均为 p < 0.05）均有所增加。鉴于甘氨酸是促进细胞内 BCAA 分解代谢所必需的物质，因此有必要测量甘氨酸以补充 BCAA 分析，从而全面了解氨基酸代谢对胰岛素敏感性的影响。临床试验注册本研究已在 ClinicalTrials.gov (NCT01777893) 上注册。

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引用次数: 0

The genetically predicted causal associations between circulating 3-hydroxybutyrate levels and malignant neoplasms: A pan-cancer Mendelian randomization study 循环中 3- 羟丁酸水平与恶性肿瘤之间的遗传预测因果关系：一项泛癌症孟德尔随机化研究。

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition

Pub Date : 2024-10-01 DOI: 10.1016/j.clnu.2024.09.044

Objective

The ketogenic diet or exogenous supplementation with 3-hydroxybutyrate (3HB) is progressively gaining recognition as a valuable therapeutic or health intervention strategy. However, the effects of 3HB on cancers have been inconsistent in previous studies. This study aimed to comprehensively investigate the causal effects of circulating 3HB levels on 120 cancer phenotypes, and explore the 3HB mediation effect between liver fat accumulation and cancers.

Methods

Univariate Mendelian randomization (UVMR) was used in this study to investigate the causal impact of circulating 3HB levels on cancers. We conducted meta-analyses for 3HB-cancer associations sourced from different exposure data. In multivariate MR(MVMR), the body mass index, alcohol frequency and diabetes were included as covariates to investigate the independent effect of 3HB on cancer risk. Additionally, utilizing mediation MR analysis, we checked the potential mediating role of 3HB in the association between liver fat and cancer.

Results

Integrating findings from UVMR and MVMR, we observed that elevated circulating 3HB levels were associated with reduced risk of developing diffuse large B-cell lymphoma(DLBCL) (OR[95%CI] = 0.28[0.14–0.57] p = 3.92e-04), biliary malignancies (OR[95%CI] = 0.30[0.15–0.60], p = 7.67e-04), hepatocellular carcinoma(HCC) (OR[95%CI] = 0.25[0.09–0.71], p = 9.33e-03), primary lymphoid and hematopoietic malignancies (OR[95%CI] = 0.76[0.58–0.99], p = 0.045). Further UVMR analysis revealed that an increase in the percent liver fat was associated with reduced 3HB levels (Beta[95%CI] = -0.073[-0.122∼-0.024], p = 0.0034) and enhanced susceptibility to HCC (OR[95%CI] = 13.9[9.76–19.79], p = 3.14e-48), biliary malignancies (OR[95%CI] = 4.04[3.22–5.07], p = 1.64e-33), nasopharyngeal cancer (OR[95%CI] = 3.26[1.10–9.67], p = 0.03), and primary lymphoid and hematopoietic malignancies (OR[95%CI] = 1.27[1.13–1.44], p = 1.04e-4). Furthermore, 3HB fully mediated the effect of liver fat on susceptibility to DLBCL (OR[95%CI] = 1.076[1.01–1.15], p = 0.034).

Conclusions

Circulating 3HB is associated with a reduced susceptibility to developing DLBCL, HCC, biliary malignancies, and primary lymphoid and hematopoietic malignancies. The impaired ketogenesis induced by metabolic-dysfunction associated fatty liver disease (MAFLD) contributes to risk of DLBCL.

目的：生酮饮食或外源性补充 3-hydroxybutyrate (3HB) 逐渐被认为是一种有价值的治疗或健康干预策略。然而，在以往的研究中，3HB 对癌症的影响并不一致。本研究旨在全面研究循环中3HB水平对120种癌症表型的因果效应，并探讨3HB在肝脏脂肪堆积与癌症之间的中介效应：方法：本研究采用单变量孟德尔随机法（UVMR）研究循环3HB水平对癌症的因果影响。我们对来自不同暴露数据的 3HB 与癌症的关系进行了荟萃分析。在多变量 MR（MVMR）中，我们将体重指数、饮酒频率和糖尿病作为协变量，以研究 3HB 对癌症风险的独立影响。此外，我们还利用中介MR分析，检验了3HB在肝脏脂肪与癌症之间关系中的潜在中介作用：结果：综合 UVMR 和 MVMR 的研究结果，我们发现循环中 3HB 水平的升高与弥漫大 B 细胞淋巴瘤（DLBCL）（OR[95%CI] = 0.28[0.14-0.57] p = 3.92e-04）、胆道恶性肿瘤（OR[95%CI] = 0.30[0.15-0.60], p = 7.67e-04）、肝细胞癌（HCC）（OR[95%CI] = 0.25[0.09-0.71], p = 9.33e-03）、原发性淋巴和造血恶性肿瘤（OR[95%CI] = 0.76[0.58-0.99], p = 0.045）。进一步的 UVMR 分析显示，肝脏脂肪百分比的增加与 3HB 水平的降低有关（Beta[95%CI] = -0.073[-0.122∼-0.024]，p = 0.0034），并增加了对 HCC 的易感性（OR[95%CI] = 13.9[9.76-19.79]，p = 3.14e-48）、胆道恶性肿瘤（OR[95%CI] = 4.04[3.22-5.07], p = 1.64e-33）、鼻咽癌（OR[95%CI] = 3.26[1.10-9.67], p = 0.03）以及原发性淋巴和造血恶性肿瘤（OR[95%CI] = 1.27[1.13-1.44], p = 1.04e-4）。此外，3HB完全介导了肝脏脂肪对DLBCL易感性的影响（OR[95%CI] = 1.076[1.01-1.15], p = 0.034）：循环中的 3HB 与 DLBCL、HCC、胆道恶性肿瘤以及原发性淋巴和造血恶性肿瘤易感性的降低有关。代谢功能障碍相关性脂肪肝（MAFLD）导致的生酮功能受损会增加罹患 DLBCL 的风险。

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引用次数: 0

Soy protein β-conglycinin ameliorates pressure overload-induced heart failure by increasing short-chain fatty acid (SCFA)-producing gut microbiota and intestinal SCFAs 大豆蛋白β-球蛋白通过增加短链脂肪酸（SCFA）产生的肠道微生物群和肠道SCFA改善压力过载引起的心力衰竭。

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition

Pub Date : 2024-10-01 DOI: 10.1016/j.clnu.2024.09.045

Background and aims

Soybeans and their ingredients have antioxidant and anti-inflammatory effects on cardiovascular diseases. β-Conglycinin (β-CG), a major constituent of soy proteins, is protective against obesity, hypertension, and chronic kidney disease, but its effects on heart failure remain to be elucidated. We tested the effects of β-CG on left ventricular (LV) remodeling in pressure overload-induced heart failure.

Methods

A transverse aortic constriction (TAC)-induced pressure overload was applied to the heart in 7-week-old C57BL6 male mice that were treated with β-CG, GlcNAc, or sodium propionate. Gut microbiota was analyzed by 16S rRNA sequencing. Fecal short-chain fatty acids (SCFAs) were quantified by GC-MS. The effects of oral antibiotics were examined in β-CG-fed mice.

Results

β-CG ameliorated impaired cardiac contractions, cardiac hypertrophy, and myocardial fibrosis in TAC-operated mice. As β-CG is a highly glycosylated protein, we examined the effects of GlcNAc. GlcNAc had similar but less efficient effects on LV remodeling compared to β-CG. β-CG increased three major SCFA-producing intestinal bacteria, as well as fecal concentrations of SCFAs, in sham- and TAC-operated mice. Oral administration of antibiotics nullified the effects of β-CG in TAC-operated mice by markedly reducing SCFA-producing intestinal bacteria and fecal SCFAs. In contrast, oral administration of sodium propionate, one of SCFAs, ameliorated LV remodeling in TAC-operated mice to a similar extent as β-CG.

Conclusions

β-CG was protective against TAC-induced LV remodeling, which was likely to be mediated by increased SCFA-producing gut microbiota and increased intestinal SCFAs. Modified β-CG and/or derivatives arising from β-CG are expected to be developed as prophylactic and/or therapeutic agents to ameliorate devastating symptoms in heart failure.

背景和目的：大豆及其成分对心血管疾病具有抗氧化和抗炎作用。大豆蛋白的主要成分β-Conglycinin（β-CG）对肥胖、高血压和慢性肾病有保护作用，但其对心力衰竭的影响仍有待阐明。我们测试了β-CG对压力过载诱导的心力衰竭左心室重塑的影响：方法：对接受β-CG、GlcNAc或丙酸钠治疗的7周大C57BL6雄性小鼠心脏施加横向主动脉收缩（TAC）诱导的压力过载。通过 16S rRNA 测序分析了肠道微生物群。粪便中的短链脂肪酸（SCFAs）通过 GC-MS 进行定量。结果：β-CG 可改善 TAC 手术小鼠受损的心脏收缩、心脏肥大和心肌纤维化。由于β-CG是一种高度糖基化的蛋白质，我们研究了GlcNAc的作用。与β-CG相比，GlcNAc对左心室重塑的影响相似，但效果较差。β-CG增加了假手术小鼠和TAC手术小鼠肠道中三种主要的SCFA产生菌以及粪便中SCFA的浓度。口服抗生素能显著减少肠道中产生 SCFA 的细菌和粪便中的 SCFA，从而抵消了 β-CG 对 TAC 手术小鼠的影响。结论：β-CG对TAC诱导的左心室重构具有保护作用，这可能是通过增加产生SCFA的肠道微生物群和增加肠道SCFA介导的。改良β-CG和/或β-CG的衍生物有望被开发为预防和/或治疗药物，以改善心衰的破坏性症状。

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引用次数: 0

Greater energy surplus promotes body protein accretion in healthy young men: A randomized clinical trial 能量过剩会促进健康年轻男性体内蛋白质的增加：随机临床试验

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition

Pub Date : 2024-09-30 DOI: 10.1016/j.clnu.2024.09.035

Background & aims

Caloric overfeeding combined with adequate protein intake increases not only body fat mass but also fat-free mass. However, it remains unclear whether the increase in fat-free mass due to overfeeding is associated with an increase in total body protein mass. We evaluated the hypothesis that overfeeding would promote an increase in total body protein mass.

Methods

In our randomized controlled trial, 23 healthy young men were fed a diet equivalent to their energy requirements with a +10 % energy surplus from protein alone or a +40 % energy surplus (+10 % from protein, +30 % from carbohydrate) for 6 weeks. We estimated total body protein mass by a four-compartment model using dual-energy X-ray absorptiometry, deuterium dilution, and hydrostatic underwater weighing.

Results

The 40 % energy surplus over 6 weeks significantly increased body protein mass compared to baseline by 3.7 % (0.44 kg; 95 % confidence interval [CI], 0.21–0.67 kg; P = 0.003); however, the 10 % energy surplus did not result in a significant change (0.00 kg; 95 % CI, −0.38–0.39 kg; P = 0.980). A significant interaction between intervention duration (time) and energy surplus (group) was observed for total body protein mass (P = 0.035, linear mixed-effects model), with a trend toward a significant difference in total body protein mass gain between groups (P = 0.059, Wilcoxon rank sum test). The increase in body protein mass due to the energy surplus was correlated with an increase in fat mass (r = 0.820, p = 0.002).

Conclusions

A higher energy intake was found to promote an increase in body protein mass in healthy men consuming excess protein, suggesting the importance of energy surplus in body protein accumulation. This effect of energy surplus may be related to factors such as increased body fat mass and the associated secretion of adipokines.

Trial registration

The trial was registered with the University Hospital Medical Information Network Clinical Trial Registry as UMIN000034158.

背景& 目的热量过量喂养加上摄入充足的蛋白质，不仅会增加体脂质量，还会增加去脂质量。然而，过度喂养导致的去脂质量增加是否与体内蛋白质总量的增加有关，目前仍不清楚。在我们的随机对照试验中，23 名健康的年轻男性在为期 6 周的时间里摄入了与他们的能量需求相当的饮食，其中仅蛋白质就提供了 +10% 的能量盈余，或 +40% 的能量盈余（蛋白质 +10%，碳水化合物 +30%）。我们使用双能 X 射线吸收测定法、氘稀释法和水下静力学称重法，通过四室模型估算了人体总蛋白质质量。7% (0.44 kg; 95 % 置信区间[CI], 0.21-0.67 kg; P = 0.003)；然而，10% 的能量盈余并没有带来显著变化 (0.00 kg; 95 % 置信区间[CI], -0.38-0.39 kg; P = 0.980)。干预持续时间（时间）与能量盈余（组别）之间存在明显的交互作用（P = 0.035，线性混合效应模型），不同组别之间身体蛋白质总量的增加有明显差异的趋势（P = 0.059，Wilcoxon 秩和检验）。结论在摄入过量蛋白质的健康男性中，较高的能量摄入可促进体内蛋白质质量的增加，这表明能量过剩在体内蛋白质积累中的重要性。试验注册该试验已在大学医院医学信息网临床试验注册中心注册，注册号为 UMIN000034158。

{"title":"Greater energy surplus promotes body protein accretion in healthy young men: A randomized clinical trial","authors":"","doi":"10.1016/j.clnu.2024.09.035","DOIUrl":"10.1016/j.clnu.2024.09.035","url":null,"abstract":"<div><h3>Background & aims</h3><div>Caloric overfeeding combined with adequate protein intake increases not only body fat mass but also fat-free mass. However, it remains unclear whether the increase in fat-free mass due to overfeeding is associated with an increase in total body protein mass. We evaluated the hypothesis that overfeeding would promote an increase in total body protein mass.</div></div><div><h3>Methods</h3><div>In our randomized controlled trial, 23 healthy young men were fed a diet equivalent to their energy requirements with a +10 % energy surplus from protein alone or a +40 % energy surplus (+10 % from protein, +30 % from carbohydrate) for 6 weeks. We estimated total body protein mass by a four-compartment model using dual-energy X-ray absorptiometry, deuterium dilution, and hydrostatic underwater weighing.</div></div><div><h3>Results</h3><div>The 40 % energy surplus over 6 weeks significantly increased body protein mass compared to baseline by 3.7 % (0.44 kg; 95 % confidence interval [CI], 0.21–0.67 kg; P = 0.003); however, the 10 % energy surplus did not result in a significant change (0.00 kg; 95 % CI, −0.38–0.39 kg; P = 0.980). A significant interaction between intervention duration (time) and energy surplus (group) was observed for total body protein mass (P = 0.035, linear mixed-effects model), with a trend toward a significant difference in total body protein mass gain between groups (P = 0.059, Wilcoxon rank sum test). The increase in body protein mass due to the energy surplus was correlated with an increase in fat mass (r = 0.820, p = 0.002).</div></div><div><h3>Conclusions</h3><div>A higher energy intake was found to promote an increase in body protein mass in healthy men consuming excess protein, suggesting the importance of energy surplus in body protein accumulation. This effect of energy surplus may be related to factors such as increased body fat mass and the associated secretion of adipokines.</div></div><div><h3>Trial registration</h3><div>The trial was registered with the University Hospital Medical Information Network Clinical Trial Registry as UMIN000034158.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor–“Effects of early enteral nutrition on persistent inflammation, immunosuppression, and catabolism syndrome in critically ill patients” 致编辑的信--"早期肠内营养对重症患者持续性炎症、免疫抑制和分解代谢综合征的影响"。

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition

Pub Date : 2024-09-30 DOI: 10.1016/j.clnu.2024.09.046

引用次数: 0

Retraction notice to ‘High protein diet improves the overall survival in older adults with advanced gastrointestinal cancer’ [Clinical Nutrition 40/3 (2021) 1376-1380] 高蛋白饮食可提高晚期胃肠道癌症老年人的总体生存率》[临床营养学 40/3 (2021) 1376-1380] 撤稿通知

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition

Pub Date : 2024-09-27 DOI: 10.1016/j.clnu.2022.04.021

引用次数: 0

Malnutrition defined by global leadership initiative on malnutrition criteria impedes home discharge in acute care hospital admissions 全球营养不良领导倡议标准所定义的营养不良阻碍了急诊入院患者的出院回家。

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition

Pub Date : 2024-09-27 DOI: 10.1016/j.clnu.2024.09.040

Background & aims

Limited evidence exists on the association between malnutrition diagnosis using the Global Leadership Initiative on Malnutrition (GLIM) criteria in hospitalized acute care patients and their outcomes; several aspects still require clarification. This study aimed to evaluate the relationship between malnutrition, as defined by the GLIM criteria, at the time of acute hospital admission and discharge to home.

Methods

This retrospective observational study was conducted at a hospital that provides acute care in Japan. Adult patients admitted between July 2023 and April 2024 were included in this study. The primary outcome was the number of patients discharged to home, with in-hospital mortality as the secondary outcome. To ensure the reliability of the cohort-wide results, background factors were adjusted using propensity score matching. The two groups were compared based on the presence or absence of malnutrition, as defined by the GLIM criteria at admission. Furthermore, multiple logistic regression analysis was conducted, with the outcome as the dependent variable and malnutrition, diagnosed using the GLIM criteria, as the explanatory variable, adjusting for covariates.

Results

A total of 1007 patients were included in the final analysis, of whom 492 (49 %) were diagnosed without malnutrition, while 515 (51 %) were diagnosed with malnutrition according to the GLIM criteria. In the multivariate logistic regression analysis after matching, malnutrition defined by the GLIM criteria emerged as an independent factor associated with discharge to home (odds ratio [OR] = 0.37, 95 % confidence interval = 0.25–0.56, P < 0.001) when adjusting for age, sex, and various comorbidities. Among the GLIM sub-criteria, reduced muscle mass, reduced food intake or assimilation, and disease burden or inflammation were independently associated with discharge to home. Notably, disease burden/inflammation exhibited the lowest OR among the GLIM sub-criteria for discharge.

Conclusion

Malnutrition diagnosed using the GLIM criteria upon admission in patients admitted to a regional hospital providing acute care was associated with decreased rates of discharge to home and increased in-hospital mortality. Specifically, attention should be paid to the criteria for reduced muscle mass and disease burden or inflammation within the GLIM framework.

背景和目的：使用全球营养不良领导倡议（GLIM）标准对住院急症患者进行营养不良诊断与患者预后之间的关系证据有限；仍有几个方面需要澄清。本研究旨在评估根据 GLIM 标准定义的急性住院患者营养不良与出院回家之间的关系：这项回顾性观察研究在日本一家提供急症护理的医院进行。研究对象包括 2023 年 7 月至 2024 年 4 月期间入院的成人患者。主要结果是出院回家的患者人数，次要结果是院内死亡率。为确保整个组群结果的可靠性，采用倾向得分匹配法对背景因素进行了调整。根据入院时的 GLIM 标准，对两组患者是否存在营养不良进行了比较。此外，还进行了多元逻辑回归分析，以结果为因变量，以根据 GLIM 标准诊断出的营养不良为解释变量，并对协变量进行了调整：共有 1007 名患者被纳入最终分析，其中 492 人（49%）被诊断为无营养不良，515 人（51%）根据 GLIM 标准被诊断为营养不良。在配对后的多变量逻辑回归分析中，根据 GLIM 标准定义的营养不良成为与出院回家相关的独立因素（几率比 [OR] = 0.37，95 % 置信区间 = 0.25-0.56，P 结论：GLIM 标准与出院回家无关）：在一家提供急症护理的地区医院住院的患者，入院时使用 GLIM 标准诊断出的营养不良与出院回家率下降和院内死亡率上升有关。特别需要注意的是，在 GLIM 框架内，肌肉质量减少和疾病负担或炎症的标准。

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引用次数: 0

Enhancing colorectal cancer survivorship: Integrating social work to optimize Dietary and lifestyle interventions 加强结肠直肠癌幸存者：整合社会工作，优化饮食和生活方式干预。

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition

Pub Date : 2024-09-27 DOI: 10.1016/j.clnu.2024.09.043

引用次数: 0

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