Contact Dermatitis最新文献

{"title":"Anogenital Contact Dermatitis in Spain: A REIDAC Study of Patients Undergoing Patch Testing in 2019–2024","authors":"Mercè Grau-Pérez,&nbsp;Pedro Mercader-García,&nbsp;Ana María Giménez-Arnau,&nbsp;Tatiana Sanz-Sánchez,&nbsp;Violeta Zaragoza Ninet,&nbsp;Susana Córdoba Guijarro,&nbsp;Francisco Javier Miquel Miquel,&nbsp;Juan Francisco Silvestre Salvador,&nbsp;Ricardo González-Pérez,&nbsp;Inmaculada Ruíz González,&nbsp;Esther Serra Baldrich,&nbsp;José Manuel Carrascosa,&nbsp;Francisco Javier Ortiz de Frutos,&nbsp;Mercedes Rodríguez Serna,&nbsp;María Elena Gatica Ortega,&nbsp;Carmen Paredes Suárez,&nbsp;Francisco José Navarro Triviño,&nbsp;Pablo Chicharro,&nbsp;Marta Andreu,&nbsp;Araceli Sánchez Gilo,&nbsp;José Juan Pereyra Rodríguez,&nbsp;María Antonia Pastor Nieto,&nbsp;Gemma Melé-Ninot,&nbsp;Paloma Sánchez-Pedreño Guillén,&nbsp;Enrique Gómez de la Fuente,&nbsp;Marta Elosua-González,&nbsp;Mónica Munera-Campos,&nbsp;Fátima Tous Romero,&nbsp;Miguel Ángel Descalzo,&nbsp;Leopoldo Borrego","doi":"10.1111/cod.70048","DOIUrl":"10.1111/cod.70048","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The REIDAC (Spanish Registry for Research in Contact Dermatitis) conducts nationwide epidemiological surveillance of contact dermatitis in Spain. Anogenital involvement within REIDAC has not been previously studied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To describe the most common diagnoses and update relevant allergens in patients with anogenital lesions referred for patch testing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analysed patients who underwent patch testing within REIDAC from 2019 to 2024. Patients were classified into three groups: (G1) exclusively anogenital lesions, (G2) no anogenital involvement and (G3) both anogenital and non-anogenital lesions. Sensitisation and relevance were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 18 291 patients, 116 (0.6%) had exclusively anogenital lesions, 17 576 (96.1%) had no anogenital involvement and 599 (3.3%) had both. G1 patients were more likely to have at least one positive reaction (91.4%), a current relevant reaction (53.4%, diagnosed with allergic contact dermatitis, ACD) and to be polysensitised compared to other groups (<i>p</i> &lt; 0.001). 14.5% of anogenital ACD identified cases were not identified by the Spanish baseline series. Fragrances, preservatives, topical anaesthetics and steroids were the leading relevant allergens. Benzisothiazolinone, sodium metabisulfite and propolis emerged as new sensitisers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ACD was highly prevalent among patients with anogenital lesions referred for patch testing. The threshold for patch testing in these patients may need reconsideration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"94 3","pages":"272-285"},"PeriodicalIF":4.6,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “A Slippery Slope: Is Benzyl Alcohol a Contact Allergen?”","authors":"Steffen Schubert,&nbsp;Barbara Ballmer-Weber,&nbsp;Timo Buhl,&nbsp;Juliane Rieker-Schwienbacher,&nbsp;Heinrich Dickel,&nbsp;Christian Apfelbacher","doi":"10.1111/cod.70066","DOIUrl":"10.1111/cod.70066","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"94 3","pages":"310-312"},"PeriodicalIF":4.6,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145699930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: A Slippery Slope: Is Benzyl Alcohol a Contact Allergen?","authors":"Richard J. Schmidt","doi":"10.1111/cod.70067","DOIUrl":"10.1111/cod.70067","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"94 3","pages":"308-309"},"PeriodicalIF":4.6,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Cohort Study on the Efficacy of Pregabalin in Patients With Sensitive Skin","authors":"Han-Bi Kim,&nbsp;Min-Gyu Choi,&nbsp;Hyung-Woo Jo,&nbsp;Ji-Young Um,&nbsp;So-Yeon Lee,&nbsp;Bo-Young Chung,&nbsp;Chun-Wook Park,&nbsp;Hye-One Kim","doi":"10.1111/cod.70063","DOIUrl":"10.1111/cod.70063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sensitive skin syndrome (SSS) is a common disorder showing abnormal responses to stimuli, without approved treatments and unclear neuropathic mechanisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate pregabalin efficacy in reducing SSS symptoms and identify predictors of treatment response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic retrospective cohort of 112 clinically diagnosed SSS patients (mean age 40.5 years). The primary outcome was sensitive scale-10 (SS-10) score change at 12 weeks; response was defined as a ≥ 30% reduction. Secondary outcomes included dermatology life quality index (DLQI), hospital anxiety and depression scale (HADS), skin biophysical parameters, von Frey thresholds and facial erythema.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 12 weeks, 46.4% of patients responded. Most patients (86.6%) received less than 75 mg/day. Higher baseline SS-10 scores (<i>r</i> = 0.5) and tingling symptoms (<i>p</i> = 0.050) were associated with greater response, while discomfort was associated with non-response (<i>p</i> = 0.005). SS-10 scores correlated with DLQI (<i>r</i> = 0.49) and total HADS (<i>r</i> = 0.29). Reduced von Frey thresholds (<i>r</i> = −0.28) and increased facial erythema (<i>r</i> = 0.39) were observed in responders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Pregabalin improved symptoms in SSS, supporting its potential role in managing neuropathic features and reinforcing the neurogenic hypothesis underlying its therapeutic mechanism.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"94 3","pages":"286-295"},"PeriodicalIF":4.6,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145660537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Risk Assessment of Diisocyanates Leaching From Wound Dressings Under Physiological Conditions","authors":"Ania Stras,&nbsp;Sarah Mannaert,&nbsp;Michaël Canfyn,&nbsp;Tine Weytjens,&nbsp;Eric Deconinck,&nbsp;Bart Desmedt,&nbsp;Tamara Vanhaecke","doi":"10.1111/cod.70061","DOIUrl":"10.1111/cod.70061","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Diisocyanates are potent sensitizers extensively used in polyurethane-based materials, with numerous case reports linking them to allergic contact dermatitis (ACD). Recent extractables studies have detected residual diisocyanates in medical devices such as wound dressings. However, these assessments typically rely on non-physiological extraction methods, limiting their relevance to actual skin exposure conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to develop and validate a physiologically relevant method for quantifying residual 4,4′-diphenylmethane diisocyanates (MDI), dicyclohexylmethane-4,4-diisocyanates (DMDI), hexamethylene diisocyanates (HDI), toluene diisocyanates (2,4- and 2,6-TDI) and isophorone diisocyanates (IPDI) leaching from wound dressings, and subsequently assess their risk of sensitisation induction and ACD elicitation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Diisocyanate standards were stabilised as di-lysine adducts in an artificial sweat solution, simulating skin exposure. An optimised LC–MS/MS method was used for quantification. The method was validated across a wide concentration range and subsequently applied to 36 commercial wound dressings. Exposure levels were evaluated against toxicological thresholds for quantitative risk assessments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The method proved reliable for all target diisocyanates (except IPDI) at concentrations ≥ 15 ppb. Analysis of the samples revealed that 44% contained quantifiable levels of residual diisocyanates. Notably, over 50% of the HDI-positive and 20% of MDI-positive samples exceeded the acceptable exposure level (AEL) for sensitisation induction. Moreover, all samples exceeding the AEL fell above the acceptable non-eliciting area dose for contact dermatitis (ANEAD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We developed and validated a physiologically relevant method to quantify diisocyanate residues leaching from wound dressings, demonstrating that HDI, in particular, poses a significant risk for sensitisation induction and can elicit ACD in individuals who are already sensitised.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"94 3","pages":"245-258"},"PeriodicalIF":4.6,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145660610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salicylate Allergy and Frontal Fibrosing Alopecia: A Case Report With Stabilisation of the Complaints After Allergen Avoidance","authors":"Sylvie Mireille Franken,&nbsp;Thomas Rustemeyer","doi":"10.1111/cod.70062","DOIUrl":"10.1111/cod.70062","url":null,"abstract":"&lt;p&gt;A 34-year-old woman was referred to the department of Dermato-Allergology because of facial complaints when using sunscreen products. The complaints had started 3 years before. She experienced itch, swelling and tingling in her face within an hour after applying several sunscreens. She later also experienced complaints after applying day cream with SPF. The complaints disappeared when avoiding SPF-containing products.&lt;/p&gt;&lt;p&gt;In her history, she mentioned she was diagnosed with frontal fibrosing alopecia (FFA). The complaints of the SPF-containing products and the FFA started simultaneously.&lt;/p&gt;&lt;p&gt;Patch tests were performed on the upper back with the European baseline series, a departmental extension, perfumes series and the patient's own products. Allergens were acquired from the series (allergens obtained from Chemotechnique Diagnostics, Vellinge, Sweden and Allergeaze, SmartPractice, Phoenix, USA). Allergens were tested using van der Bend test chambers (van der Bend, Brielle, the Netherlands) with Omnifix Elastic (Hartmann, Neuhausen, Switzerland). Readings and tests were performed on day (D) 2 and D3 according to the ESCD guideline.&lt;/p&gt;&lt;p&gt;Tests were positive for benzyl salicylate 10% pet (D2: +, D3: +), epoxy resin 1.0% pet (D2: +, D3: ++), fragrance mix 1 8.0% pet (D2: –, D3: +), nickel sulphate 5% pet (D2: –, D3: +), limonene hydroperoxide 0.3% pet (D2: +, D3: ++), imidazolidinyl urea 2.0% pet (D2: –, D3: +) and Paula's Choice broad spectrum SPF30 as is (D2: +, D3: +).&lt;/p&gt;&lt;p&gt;The reaction to her own skin care product was deemed clinically relevant. After checking the ingredient list however, none of the discovered allergens was used in the product. We therefore decided to perform additional patch tests with the photopatch series (without UV exposure), textile finishes (because of the imidazolidinyl urea reaction), perfumes and flavours series and acetyl salicylic acid. Salicylic acid was not available at the time of patch testing this patient due to logistic problems. Positive reactions were found for homosalate (trimethylcyclohexyl salicylate) 10% pet (D2: +, D3: +) and octyl salicylate (ethylhexylsalicylate) 10% pet (D2: +, D3: +). The reactions covered the whole test area, as shown in Figure 1.&lt;/p&gt;&lt;p&gt;Homosalate was one of the ingredients in her Paula's Choice Ultra Sheer day cream. After specifically avoiding salicylates in SPF-containing products and the other identified allergens, the skin complaints alleviated. The FFA remained present, though stable.&lt;/p&gt;&lt;p&gt;After avoiding the allergens for several months, specifically the salicylates, the patient felt her complaints of tingling/itching and skin rash disappeared. She also mentioned that the activity of her FFA had stabilised without any further therapeutic approach. The hair loss was not reversible, as was to be expected because of the cicatricial nature of the disease.&lt;/p&gt;&lt;p&gt;In our patient positive patch tests were found for three different salicylates: benzyl salicylate (CAS 118–58-1","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"94 3","pages":"306-307"},"PeriodicalIF":4.6,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of GC–MS Analyses of 40 Extracts of Diabetes Devices","authors":"Emma M. van Oers,&nbsp;Anton C. de Groot,&nbsp;Patrick Verolme,&nbsp;Norbertus A. Ipenburg,&nbsp;Thomas Rustemeyer","doi":"10.1111/cod.70052","DOIUrl":"10.1111/cod.70052","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Diagnostic patch testing in patients with suspected allergic Contact Dermatitis from glucose sensors, insulin pumps, and infusion sets is seriously hampered by a lack of information on the chemical composition of these diabetes devices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To identify the chemicals present in diabetes devices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Forty acetone extracts of 27 devices (10 sensors, 3 patch pumps, 12 infusion sets and 2 single adhesives) were investigated by gas chromatography—mass spectrometry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two hundred eighty four individual chemicals were identified. All 40 extracts contained one or more chemicals that were previously identified as allergens in diabetes devices causing allergic Contact Dermatitis. Fourteen of 27 devices (52%) contained one or more acrylates, 8 (30%) colophonium derivatives, all 27 (100%) one or two phenolic allergens (2,4-di-<i>tert</i>-butylphenol, <i>p</i>-<i>tert-</i>butylphenol, butylated hydroxytoluene), and 9 (33%) 1-hydroxycyclohexyl phenyl ketone. None of the other chemicals were well-known haptens, with the exception of bisphenol A, which was present in half of the extracts, in some cases in very high concentrations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>All products investigated contained chemicals already known to be sensitizers in diabetes devices. The data can help determine the relevance of positive patch tests, facilitate targeted patch testing with potential allergens and aid in advising safer alternatives for sensitized patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"94 3","pages":"234-244"},"PeriodicalIF":4.6,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145630820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Study of Contact Allergens in Hotel Personal Care Products in Canada, the United States and Europe","authors":"Vanessa Viltakis,&nbsp;Mark G. Kirchhof","doi":"10.1111/cod.70057","DOIUrl":"10.1111/cod.70057","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Personal care products (PCPs), such as shampoos, conditioners and body washes, can contain ingredients that may cause allergic contact dermatitis (ACD). Hotels commonly offer complimentary toiletries; however, there is limited data regarding the allergen content of these products.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to identify allergens within PCPs that may cause ACD in hotels across Canada, the United States (US) and Europe.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional analysis was conducted to identify American Contact Dermatitis Society (ACDS) core allergens listed in the ingredients of PCPs sampled from 90 hotels across Canada, the US and Europe. Hotels were stratified equally into luxury, mid-scale and budget-friendly categories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) was found in 4.4% of hotel products in Europe, which is significantly lower than its prevalence in Canada (47.8%) and the US (40.0%) (<i>p</i> &lt; 0.0001). In Canada and the US, DMDM hydantoin, a formaldehyde-releasing preservative, was detected in approximately one in seven products but was absent in the toiletries from European hotels (Canada vs. Europe: <i>p</i> = 0.01; US vs. Europe: <i>p</i> = 0.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A higher percentage of multiple ACDS core allergens were identified in complimentary hotel toiletries in Canada and the US than in Europe. This study underscores the importance of patient and clinician awareness of the potential risk of ACD resulting from exposure to hotel products.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"94 2","pages":"173-181"},"PeriodicalIF":4.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Hair Dye Use With Sociodemographic and Lifestyle Factors in the Dutch General Population: A Cross-Sectional Questionnaire-Based Study","authors":"Fieke M. Rosenberg,&nbsp;Robert F. Ofenloch,&nbsp;Peter J. van der Most,&nbsp;Laura Loman,&nbsp;Harold Snieder,&nbsp;Marie L. A. Schuttelaar","doi":"10.1111/cod.70053","DOIUrl":"10.1111/cod.70053","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sociodemographic and lifestyle factors may be related to the use of cosmetic procedures with potential adverse skin effects, such as hair dye use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the association of several sociodemographic and lifestyle factors with (adverse skin reactions to) hair dye use in the Dutch general population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study used questionnaire-derived data from the population-based Lifelines cohort regarding lifetime hair dye use and adverse skin reactions (<i>n</i> = 70 987). Logistic regression analyses investigated associations of sociodemographic factors (ethnicity, hair colour, marital status, educational attainment, income, neighbourhood socioeconomic status) and lifestyle factors (smoking, alcohol consumption, and body mass index [BMI]) with adverse skin reactions to hair dye use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Hair dye use was significantly positively associated with having dark blonde or brown hair colour, lower educational attainment, smoking, daily alcohol consumption and higher BMI. Hair dye use was significantly negatively associated with having red or auburn hair colour. Furthermore, adverse skin reactions to hair dye were significantly positively associated with higher BMI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings highlight several positive associations between sociodemographic and lifestyle factors and both hair dye use and its adverse skin reactions. Notably, elevated BMI was consistently positively associated with both hair dye use and adverse skin reactions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"94 2","pages":"137-148"},"PeriodicalIF":4.6,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Contact Dermatitis to Terminalia Chebula Fruit Extract in Antiaging Creams","authors":"Maël Blanchard,&nbsp;Ophélie Marchal,&nbsp;Gabriela Blanchard,&nbsp;Pierre Piletta-Zanin","doi":"10.1111/cod.70060","DOIUrl":"10.1111/cod.70060","url":null,"abstract":"&lt;p&gt;Allergic contact dermatitis (ACD) is the most common cause of eyelid dermatitis [&lt;span&gt;1&lt;/span&gt;]. Cosmetic creams are a major source of eyelid ACD cases, due to contact allergens such as fragrances, preservatives, emulsifiers and nickel. The cosmetics industry has long relied on natural plant resources to discover new active ingredients. We report the first case of eyelid ACD to Terminalia Chebula Fruit Extract in a cosmetic night cream.&lt;/p&gt;&lt;p&gt;A 31-year-old Caucasian atopic female developed a recurrent, well-demarcated, itchy eyelid (Figure 1A) and lip erythema. Patch tests were performed using the European baseline, preservative and eyelid series (Chemotechnique Diagnostics, Vellinge, Sweden) using IQ Ultra chambers (Chemotechnique Diagnostics) and the patient's own products (‘as is’). Allergens were applied for 48 h. Readings on day (D) 2 and D4 showed positive reactions for Hyaluron Activ B3 triple correction eye cream (+++) and Hyaluron Activ B3 multi-intensive night cream (+) (Avène, France) (Figure 1B). The European baseline, preservative and eyelid series were all negative except for a +++ positive reaction to paraphenylenediamine (PPD), which was not considered relevant to the current skin reactions. Indeed, the patient presented a strong response to a henna tattoo during adolescence.&lt;/p&gt;&lt;p&gt;Thus, we hypothesized that the personal creams showing a positive reaction, likely contained a common allergen that was not detected in our standard test panels. The individual ingredients of both, Hyaluron Activ B3 triple correction eye cream and multi-intensive night cream, kindly provided by the manufacturer, were subsequently patch-tested. They showed a positive reaction (D2+, D4++) to a single ingredient, Terminalia Chebula Fruit Extract (Figure 1C). Five unexposed controls were negative to this extract.&lt;/p&gt;&lt;p&gt;Positive patch tests for both Hyaluron Activ B3 triple correction eye cream and multi-intensive night cream and for only one of their ingredients confirm the diagnosis of ACD caused by Terminalia Chebula Fruit Extract. Amine-based PPD and phenolic compounds from this fruit share an aromatic ring structure as part of their molecular backbone, but we did not identify any direct structural similarity between them. \u0000 &lt;i&gt;T. chebula&lt;/i&gt;\u0000 Retz. is an Asian plant from the Combretaceae family which is commonly used in Tibetan and Ayurvedic medicine for various indications [&lt;span&gt;2, 3&lt;/span&gt;], especially antioxidant activity. The topical use has been suggested to treat tinea corporis [&lt;span&gt;4&lt;/span&gt;], as well as for anti-aging purposes [&lt;span&gt;5&lt;/span&gt;] with an overall good toxicity profile [&lt;span&gt;2&lt;/span&gt;]. To date, more than one hundred compounds have been identified for its fruit's extracts, including phenolic acids, tannins, lignans, triterpenoids, flavonoids and volatiles. Among others, gallate esters (derivatives from gallic acid), ellagic acid and caffeic acid could potentially be implicated given their already document","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"94 2","pages":"196-197"},"PeriodicalIF":4.6,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}