Anna Schultz Vinge, Lone Skov, Jeanne Duus Johansen, Anna Sophie Quaade
BackgroundAtopic dermatitis (AD) and hand eczema often co‐occur, particularly among adults.ObjectivesTo examine the interplay between AD and hand eczema in the general population, by characterising prevalence, disease severity, contact sensitization, and comorbidities in individuals with one or both conditions.Materials and MethodsIn this cross‐sectional study, 100 000 randomly selected adults in the Danish general population received a questionnaire via a secure, digital mailbox linked to their civil registration number. Participants answered questions regarding eczema, disease severity, patch testing, and comorbidities.ResultsA total of 40 007 individuals responded to the question on a lifetime prevalence of AD, and the prevalence among adult Danes was 9.0%. Nearly one third of individuals with AD reported moderate to severe disease. AD was associated with contact sensitization and increased hand eczema prevalence. Individuals with both AD and hand eczema reported worse disease severity. Furthermore, having both conditions was associated with an increased risk of psychiatric comorbidities.ConclusionsThis study provided updated information about unselected adults with AD in Denmark. Individuals with both AD and hand eczema represent a vulnerable subgroup that physicians should be attentive to.
背景特应性皮炎（AD）和手部湿疹经常同时发生，尤其是在成年人中。目的通过描述患有一种或两种疾病的人的患病率、疾病严重程度、接触过敏性和合并症，研究普通人群中特应性皮炎和手部湿疹之间的相互作用。参与者回答了有关湿疹、疾病严重程度、斑贴测试和合并症的问题。结果共有 40 007 人回答了有关 AD 终生患病率的问题，丹麦成年人的患病率为 9.0%。近三分之一的 AD 患者报告患有中度至重度疾病。注意力缺失症与接触致敏和手部湿疹患病率增加有关。同时患有注意力缺失症和手部湿疹的患者的疾病严重程度更严重。此外，同时患有这两种疾病与精神疾病合并症的风险增加有关。同时患有注意力缺失症和手部湿疹的人是一个易受伤害的亚群体，医生应予以关注。
{"title":"Atopic dermatitis and hand eczema in Danish adults: A nationwide population‐based study","authors":"Anna Schultz Vinge, Lone Skov, Jeanne Duus Johansen, Anna Sophie Quaade","doi":"10.1111/cod.14691","DOIUrl":"https://doi.org/10.1111/cod.14691","url":null,"abstract":"BackgroundAtopic dermatitis (AD) and hand eczema often co‐occur, particularly among adults.ObjectivesTo examine the interplay between AD and hand eczema in the general population, by characterising prevalence, disease severity, contact sensitization, and comorbidities in individuals with one or both conditions.Materials and MethodsIn this cross‐sectional study, 100 000 randomly selected adults in the Danish general population received a questionnaire via a secure, digital mailbox linked to their civil registration number. Participants answered questions regarding eczema, disease severity, patch testing, and comorbidities.ResultsA total of 40 007 individuals responded to the question on a lifetime prevalence of AD, and the prevalence among adult Danes was 9.0%. Nearly one third of individuals with AD reported moderate to severe disease. AD was associated with contact sensitization and increased hand eczema prevalence. Individuals with both AD and hand eczema reported worse disease severity. Furthermore, having both conditions was associated with an increased risk of psychiatric comorbidities.ConclusionsThis study provided updated information about unselected adults with AD in Denmark. Individuals with both AD and hand eczema represent a vulnerable subgroup that physicians should be attentive to.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jelena Kovačić, Zrinka Franić, Adrijana Bjelajac, Jelena Macan
BackgroundThe validity of the self‐report questionnaire for hand eczema (HE) among Croatian hairdressers was not investigated previously, leading to uncertainty in the prevalence estimated from self‐reported data.ObjectivesTo (1) investigate the validity of the self‐report questionnaire for HE in hairdressing apprentices and (2) examine the differences between apprentices who recognised their HE symptoms and those who did not.MethodsClinical examination for HE signs on hands and wrists was performed by the Osnabrueck Hand Eczema Severity Index for 408 apprentices at four visits covering the entire schooling period. Self‐report HE was based on the Nordic Occupational Skin Questionnaire.ResultsLow sensitivity (7%–37%) with high specificity (≥95%) was observed, with both measures improving from baseline to last visit. The severity of HE signs was the only factor associated with the correct identification of HE signs in analyses adjusted for previous HE signs, health‐related quality of life, and atopic dermatitis (adjusted odds ratios of 1.58 with 95% confidence interval [1.06–2.35] and 1.74[1.38–2.19] at second and third follow‐up visit, respectively).ConclusionsSelf‐report questionnaire for HE showed low sensitivity in hairdressing apprentices, especially at the beginning of training and in those with mild symptoms. Further validation studies following questionnaire modifications aimed at adolescent population are advised.
背景以前没有调查过克罗地亚美发师手部湿疹（HE）自我报告问卷的有效性，因此根据自我报告数据估算的患病率存在不确定性。方法采用奥斯纳布吕克手部湿疹严重程度指数（Osnabrueck Hand Eczema Severity Index）对 408 名学徒的手部和腕部湿疹症状进行临床检查，共进行了四次检查，涵盖整个在校学习期间。结果 观察到的灵敏度较低（7%-37%），特异性较高（≥95%），从基线到最后一次就诊，这两项指标均有所改善。在对以往的 HE 征兆、健康相关生活质量和特应性皮炎进行调整后的分析中，HE 征兆的严重程度是唯一与正确识别 HE 征兆相关的因素（第二次和第三次随访时的调整赔率分别为 1.58，95% 置信区间为 [1.06-2.35] 和 1.74[1.38-2.19]）。建议在针对青少年群体修改问卷后，进一步开展验证研究。
{"title":"Low sensitivity of a self‐report questionnaire for hand eczema in hairdressing apprentices","authors":"Jelena Kovačić, Zrinka Franić, Adrijana Bjelajac, Jelena Macan","doi":"10.1111/cod.14686","DOIUrl":"https://doi.org/10.1111/cod.14686","url":null,"abstract":"BackgroundThe validity of the self‐report questionnaire for hand eczema (HE) among Croatian hairdressers was not investigated previously, leading to uncertainty in the prevalence estimated from self‐reported data.ObjectivesTo (1) investigate the validity of the self‐report questionnaire for HE in hairdressing apprentices and (2) examine the differences between apprentices who recognised their HE symptoms and those who did not.MethodsClinical examination for HE signs on hands and wrists was performed by the Osnabrueck Hand Eczema Severity Index for 408 apprentices at four visits covering the entire schooling period. Self‐report HE was based on the Nordic Occupational Skin Questionnaire.ResultsLow sensitivity (7%–37%) with high specificity (≥95%) was observed, with both measures improving from baseline to last visit. The severity of HE signs was the only factor associated with the correct identification of HE signs in analyses adjusted for previous HE signs, health‐related quality of life, and atopic dermatitis (adjusted odds ratios of 1.58 with 95% confidence interval [1.06–2.35] and 1.74[1.38–2.19] at second and third follow‐up visit, respectively).ConclusionsSelf‐report questionnaire for HE showed low sensitivity in hairdressing apprentices, especially at the beginning of training and in those with mild symptoms. Further validation studies following questionnaire modifications aimed at adolescent population are advised.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ville Wikström, Suvi‐Päivikki Sinikumpu, Jari Jokelainen, Laura Huilaja
BackgroundAllergic contact dermatitis (ACD) may be chronic and can cause distress, disability, and absence from work. Nationwide epidemiological studies of ACD are sparse.ObjectivesTo use national registry data to study the incidence and aetiology of ACD in the working age population of Finland.MethodsPatient records from the years 1998–2021 were obtained from the Finnish Care Register for Health Care. Study subjects aged 18–65 years were selected on the basis of a diagnosis of ACD.ResultsTotal number of study subjects was 26 701. The incidence of ACD increased until 2016 after which it started to decrease. The increase was more marked in females and ACD was particularly common in women reporting reactions to cosmetics and other chemical products and in people of both sexes reacting to adhesives. The incidence ‘ACD of unspecific cause’ has decreased since 2016. The most commonly reported allergens were metals, followed by cosmetics. One fourth of subjects had ≥2 ACD diagnoses.ConclusionsThe incidence of ACD in working age subjects rose from 1998 to 2016, especially in females. However, the incidence has been decreasing since 2016. Our findings highlight the ongoing and even increasing burden of ACD among the working age population.
{"title":"Incidence of allergic contact dermatitis in Finland 1998–2021: A nationwide registry‐based study","authors":"Ville Wikström, Suvi‐Päivikki Sinikumpu, Jari Jokelainen, Laura Huilaja","doi":"10.1111/cod.14688","DOIUrl":"https://doi.org/10.1111/cod.14688","url":null,"abstract":"BackgroundAllergic contact dermatitis (ACD) may be chronic and can cause distress, disability, and absence from work. Nationwide epidemiological studies of ACD are sparse.ObjectivesTo use national registry data to study the incidence and aetiology of ACD in the working age population of Finland.MethodsPatient records from the years 1998–2021 were obtained from the Finnish Care Register for Health Care. Study subjects aged 18–65 years were selected on the basis of a diagnosis of ACD.ResultsTotal number of study subjects was 26 701. The incidence of ACD increased until 2016 after which it started to decrease. The increase was more marked in females and ACD was particularly common in women reporting reactions to cosmetics and other chemical products and in people of both sexes reacting to adhesives. The incidence ‘ACD of unspecific cause’ has decreased since 2016. The most commonly reported allergens were metals, followed by cosmetics. One fourth of subjects had ≥2 ACD diagnoses.ConclusionsThe incidence of ACD in working age subjects rose from 1998 to 2016, especially in females. However, the incidence has been decreasing since 2016. Our findings highlight the ongoing and even increasing burden of ACD among the working age population.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antoine Badaoui, Anne-Claire Fougerousse, Aude Roussel
{"title":"Allergic contact dermatitis to octyl and butylcyanoacrylate as well as formaldehyde in Leukosan® surgical glue.","authors":"Antoine Badaoui, Anne-Claire Fougerousse, Aude Roussel","doi":"10.1111/cod.14689","DOIUrl":"https://doi.org/10.1111/cod.14689","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Results: Sixty-four patients (48F/16M; mean age 47 ± 18) were included, mostly with maculopapular exanthema (51, 80%). Notably, CTX was sole suspect in 24 patients. There was no positive reaction to CTX at 10% from Chemotechnique or Bactrim DS® tablets prepared at 10% pet for patch testing. One patient reacted exclusively to trimethoprim with 1+ reaction. Two patients had a faint reaction (1+) only with the powder of Bactrim DS® tablets in water at D2, but as the reactions faded completely in 24 or 48 h, they were interpreted as irritant non-specific reactions.
Conclusion: These findings suggest that patch testing may lack sufficient sensitivity to diagnose CTX-induced non-immediate CADR. Therefore, clinicians should be cautious interpreting CTX patch test results.
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