Contact Dermatitis最新文献

Background: Allergic contact dermatitis (ACD) induced by topical application of neomycin is frequently reported.

Objectives: This multi-center study investigated prevalence and determinants of neomycin sensitisations in 30 629 outpatients from North-eastern Italy during 1997-2021.

Patients and methods: European baseline and extended Triveneto series were applied on the upper back of patients patch testing for suspected ACD and removed after 48 h.

Results: Prevalence of neomycin sensitisation was 2.29% (=701/30 629), significantly decreasing over time, especially after 2003. Neomycin sensitisation increased with age, especially in female patients older than 60 with leg dermatitis. The majority of patients sensitised to neomycin (74.5%) tested positive also against other haptens, particularly ingredients included in creams and emollients, as lanolin or benzocaine or preservatives as thimerosal or parabens.

Conclusions: The decreasing prevalence of neomycin sensitisation over time likely reflected reduced accessibility and circulation of neomycin in Italy, due to containment of prescriptions and over-the-counter accessibility. Older individuals are typically more likely to be treated by topical medications and antibiotics as neomycin for various conditions, including stasis dermatitis. Since ACD caused by topical medications is relatively easy to miss, comprehensive drug history and patch testing are essential for any patient with suspected sensitisation caused by neomycin.

Background: Hand eczema (HE) is common among hospital cleaners, yet no specific prevention programme exists for this group in Denmark.

Objectives: To evaluate the effectiveness of visual aids (pictograms and video scenes) based on evidence-based skin care and protection recommendations on HE outcomes, focusing on disease severity, point prevalence and skin care and protection knowledge.

Methods: A cluster-randomised controlled trial was conducted in professional cleaners from three Danish hospitals. Intervention Group A received pictograms, video clips and a short group-based educational session. Intervention Group B received only pictograms and video clips. The control group received treatment as usual. HE severity and prevalence were assessed clinically, while knowledge was measured using self-reported data.

Results: Out of 234 invited cleaners, 224 (96%) participated (Intervention Group A: 73, Intervention Group B: 78, Control Group: 73). After 24 weeks, both intervention groups showed significant reductions in HE severity and prevalence compared to the control group. Knowledge of skin care and protection also improved significantly in both intervention groups.

Conclusion: Visual aids effectively reduced HE prevalence and severity in hospital cleaners. Pictograms are a cost-effective strategy that can be widely implemented, addressing the substantial burden of HE in the cleaning industry across diverse settings.

Background: The epidemiology of chronic hand eczema (CHE) remains poorly examined.

Objective: To investigate the prevalence of CHE in a general adult population and describe the characteristics of affected individuals.

Methods: We investigated the prevalence and characteristics of CHE using a random sample from the general Danish population (The Danish Skin Cohort). CHE was defined as eczema on the hands or wrists during a minimum of three consecutive months or reoccurrence of hand eczema at least twice within 12 months.

Results: Out of 11 166 adults, 1306 experienced hand eczema (HE) at some point in their lifetime. Within the last 12 months, 408 (3.7%) experienced HE, of which 332 (81.4%) reported CHE. The crude 1-year period prevalence of CHE was 3.0% (95% confidence interval (CI), 2.7%-3.3%) while the standardised prevalence was 3.5% (95% CI, 3.3%-3.6%). Among adults with CHE, 70.8% were female, and the mean age was 48.0 years (standard deviation 16.6 years). Most individuals with CHE had two relapses (n = 309, 93.1%), while n = 206, 61.1%, had HE for more than 3 months. Compared to HE, CHE was more likely diagnosed by a dermatologist and affect the fingers and back of the hand.

Conclusion: The standardised prevalence was 3.5% (95% CI, 3.3%-3.6%) and 4.2% (95% CI, 4.0%-4.4%) for CHE and HE, respectively. We identified a large overlap between HE and CHE (81.4%) in adults from the general population, indicating that many individuals affected by eczema on the hands may experience a chronic course.

Background: Henna is a powdered plant material traditionally used for medicinal and cosmetic purposes in Asia and the Mediterranean region. In North America and Europe, however, it is only used to colour the hair and decorate the body. This colouring process is due to the action of the secondary metabolite lawsone, which enables henna to produce orange to red shades of colour. The final colour effect of the henna treatment on the hair depends on many factors, including the amount of lawsone in the product used. Unfortunately, there are also henna products on the market that contain the strong allergen para-phenylenediamine (PPD). Henna products whose manufacturers do not inform consumers about the addition of PPD are a particular problem.

Objectives: The aim of this study was therefore not only the qualitative and quantitative evaluation of lawsone but also of PPD in selected products offered for sale as henna.

Methods: Since HPLC assays are one of the most sensitive, rapid and reliable methods for the quality control of herbal raw materials, we developed and validated two independent HPLC methods with UV detection for both analytes.

Results and conclusions: We found that only about 60% of the tested cosmetic products were good quality natural products containing not < 0.5% lawsone (the range was between 0.5% and 1.0%). On the other hand, up to 36% of the henna samples contained PPD (the range was between 1% and 9%), and only three out of five of these products were properly labelled. Unfortunately, most of the henna used by Polish consumers comes from online retailers and can be shipped from different regions of the world. It is difficult to adequately control this market. Therefore, proper consumer education and awareness of the risk of PPD exposure when using henna could also be crucial for the prevention and management of PPD allergy.