{"title":"Kintsugi: A novel cause of urushiol-induced allergic contact dermatitis.","authors":"S Hughes, F J Ferguson, I R White, E Benton","doi":"10.1111/cod.14685","DOIUrl":"https://doi.org/10.1111/cod.14685","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaja Irgens-Hansen, Bjørg Eli Hollund, Hilde Kristin Vindenes
{"title":"Allergic contact dermatitis in response to contact with polychloroprene.","authors":"Kaja Irgens-Hansen, Bjørg Eli Hollund, Hilde Kristin Vindenes","doi":"10.1111/cod.14681","DOIUrl":"https://doi.org/10.1111/cod.14681","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Hand eczema (HE) is a common skin disease with a negative impact on patients' quality of life in occupational and non-occupational settings. Up-to-date, data on HE in Italian patients referred for patch testing are lacking.
Objectives: To characterise the profile in terms of demographics, aetiology and patch test results of Italian patients affected by HE referred for patch testing.
Methods: A retrospective descriptive study on consecutive patients affected by HE who underwent patch testing from 2016 to 2023 in eight dermatology clinics was performed. HE patients were divided into two groups according to the exclusive (HE-only group) and not-exclusive (HE+ group) hand involvement, and compared to patients with eczema localised in body areas other than hands (NHE group).
Results: One thousand five hundred and ninety-seven patients were affected by HE (35.3% males; mean age 42.7 years), 60.2% belonging to the HE-only group and 39.8% to the HE+ group. Occupational dermatitis was diagnosed in 33.2% of HE-only patients, 25.0% of HE+ patients and 5.2% of NHE patients (p < 0.001). HE-only patients presented: Allergic Contact Dermatitis (ACD), Irritant Contact Dermatitis (ICD), atopic HE in 48.1%, 47.5% and 7.1%, respectively; hyperkeratotic palmar, acute recurrent vesicular and nummular clinical subtypes in 52.2%, 43.9% and 11.9%, respectively; relevant positive patch test reactions in 48.1% (nickel sulphate 18.9%, methylchloroisothiazolinone/methylisothiazolinone 10.6%, methylisothiazolinone 8.6%, p-phenylenediamine 6.0% and potassium dichromate 4.7%).
Conclusions: HE patients, and particularly those with exclusive hand involvement, show a particular profile in terms of demographic and clinical characteristics, etiologies and relevant positive patch test reactions.
背景:手部湿疹(HE)是一种常见的皮肤病,对患者在职业和非职业环境中的生活质量有负面影响。目前尚缺乏意大利患者接受斑贴试验后出现手部湿疹的最新数据:目的:从人口统计学、病因学和斑贴试验结果等方面描述转诊接受斑贴试验的意大利 HE 患者的特征:方法:对 2016 年至 2023 年期间在八家皮肤科诊所接受斑贴测试的连续 HE 患者进行回顾性描述研究。根据手部完全受累(HE-only 组)和非完全受累(HE+ 组)将手部湿疹患者分为两组,并与手部以外身体其他部位湿疹患者(NHE 组)进行比较:共有 1597 名手部湿疹患者(35.3% 为男性,平均年龄 42.7 岁),其中 60.2% 属于纯手部湿疹组,39.8% 属于手部湿疹+ 组。33.2%的纯 HE 患者、25.0% 的 HE+ 患者和 5.2%的 NHE 患者被诊断出患有职业性皮炎(P 结论):职业性皮炎患者,尤其是手部完全受累的职业性皮炎患者,在人口统计学和临床特征、病因和相关的阳性斑贴试验反应方面表现出特殊的特征。
{"title":"Hand eczema in Italian patients referred for patch testing: A retrospective SIDAPA study (2016-2023).","authors":"Luca Stingeni, Maddalena Napolitano, Katharina Hansel, Caterina Foti, Monica Corazza, Alessandro Borghi, Rosella Gallo, Cataldo Patruno, Donatella Schena, Maria Michela Lauriola, Gabriele Casciola, Roberta Giuffrida, Fabrizio Guarneri","doi":"10.1111/cod.14684","DOIUrl":"https://doi.org/10.1111/cod.14684","url":null,"abstract":"<p><strong>Background: </strong>Hand eczema (HE) is a common skin disease with a negative impact on patients' quality of life in occupational and non-occupational settings. Up-to-date, data on HE in Italian patients referred for patch testing are lacking.</p><p><strong>Objectives: </strong>To characterise the profile in terms of demographics, aetiology and patch test results of Italian patients affected by HE referred for patch testing.</p><p><strong>Methods: </strong>A retrospective descriptive study on consecutive patients affected by HE who underwent patch testing from 2016 to 2023 in eight dermatology clinics was performed. HE patients were divided into two groups according to the exclusive (HE-only group) and not-exclusive (HE+ group) hand involvement, and compared to patients with eczema localised in body areas other than hands (NHE group).</p><p><strong>Results: </strong>One thousand five hundred and ninety-seven patients were affected by HE (35.3% males; mean age 42.7 years), 60.2% belonging to the HE-only group and 39.8% to the HE+ group. Occupational dermatitis was diagnosed in 33.2% of HE-only patients, 25.0% of HE+ patients and 5.2% of NHE patients (p < 0.001). HE-only patients presented: Allergic Contact Dermatitis (ACD), Irritant Contact Dermatitis (ICD), atopic HE in 48.1%, 47.5% and 7.1%, respectively; hyperkeratotic palmar, acute recurrent vesicular and nummular clinical subtypes in 52.2%, 43.9% and 11.9%, respectively; relevant positive patch test reactions in 48.1% (nickel sulphate 18.9%, methylchloroisothiazolinone/methylisothiazolinone 10.6%, methylisothiazolinone 8.6%, p-phenylenediamine 6.0% and potassium dichromate 4.7%).</p><p><strong>Conclusions: </strong>HE patients, and particularly those with exclusive hand involvement, show a particular profile in terms of demographic and clinical characteristics, etiologies and relevant positive patch test reactions.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Livia F Soriano, M M U Chowdhury, Philippa Cousen, Simon Dawe, Sharizan A Ghaffar, Adam Haworth, Catherine R Holden, Aoife Hollywood, Graham A Johnston, Stephen Kirk, Avad A Mughal, David I Orton, Robin Parker, Asha Rajeev, Krisztina Scharrer, Aparna Sinha, Natalie M Stone, Donna Thompson, Sarah Wakelin, Heather Whitehouse, Catriona Wootton, Deirdre A Buckley
Background: Acrylate polymers and cross-polymers (ACPs) are frequently used cosmetic ingredients. The British Society for Cutaneous Allergy (BSCA) and the UK Cosmetic, Toiletry and Perfumery Association (CTPA) collaborated to investigate the allergenic potential of three commonly-used ACPs.
Objectives: The objective of this study is to determine the prevalence of allergic contact dermatitis (ACD) to three ACPs: glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate, and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®).
Materials and methods: The BSCA prospectively audited data collected from 20 centres in the UK and Ireland between 1st September 2021 and 1st September 2022. Patients with suspected ACD to (meth)acrylates, with facial dermatitis, or consecutive patients, were patch tested to glyceryl acrylate/acrylic acid co-polymer 10% aqueous (aq.) sodium polyacrylate 2% aq., and to acrylates/C10-30 alkyl acrylate cross-polymer 2% aq. (Carbopol®). The frequencies of positive, irritant, and doubtful reactions were recorded.
Results: In total, 1302 patients were patch tested. To glyceryl acrylate/acrylic acid co-polymer, there was one doubtful reaction in a patient allergic to multiple (meth)acrylates, and one irritant. To sodium polyacrylate, there were four irritant reactions, one doubtful, and one positive reaction; in all cases, relevance was unknown and there was no demonstrable (meth)acrylate allergy. There were no reactions to Carbopol®.
Conclusions: Sensitisation to these concentrations of the three tested ACPs is rare. Elicitation of dermatitis in (meth)acrylate-sensitised patients by exposure to these three ACPs appears unlikely.
{"title":"Sensitisation to the acrylate co-polymers glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®) is rare.","authors":"Livia F Soriano, M M U Chowdhury, Philippa Cousen, Simon Dawe, Sharizan A Ghaffar, Adam Haworth, Catherine R Holden, Aoife Hollywood, Graham A Johnston, Stephen Kirk, Avad A Mughal, David I Orton, Robin Parker, Asha Rajeev, Krisztina Scharrer, Aparna Sinha, Natalie M Stone, Donna Thompson, Sarah Wakelin, Heather Whitehouse, Catriona Wootton, Deirdre A Buckley","doi":"10.1111/cod.14679","DOIUrl":"https://doi.org/10.1111/cod.14679","url":null,"abstract":"<p><strong>Background: </strong>Acrylate polymers and cross-polymers (ACPs) are frequently used cosmetic ingredients. The British Society for Cutaneous Allergy (BSCA) and the UK Cosmetic, Toiletry and Perfumery Association (CTPA) collaborated to investigate the allergenic potential of three commonly-used ACPs.</p><p><strong>Objectives: </strong>The objective of this study is to determine the prevalence of allergic contact dermatitis (ACD) to three ACPs: glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate, and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®).</p><p><strong>Materials and methods: </strong>The BSCA prospectively audited data collected from 20 centres in the UK and Ireland between 1st September 2021 and 1st September 2022. Patients with suspected ACD to (meth)acrylates, with facial dermatitis, or consecutive patients, were patch tested to glyceryl acrylate/acrylic acid co-polymer 10% aqueous (aq.) sodium polyacrylate 2% aq., and to acrylates/C10-30 alkyl acrylate cross-polymer 2% aq. (Carbopol®). The frequencies of positive, irritant, and doubtful reactions were recorded.</p><p><strong>Results: </strong>In total, 1302 patients were patch tested. To glyceryl acrylate/acrylic acid co-polymer, there was one doubtful reaction in a patient allergic to multiple (meth)acrylates, and one irritant. To sodium polyacrylate, there were four irritant reactions, one doubtful, and one positive reaction; in all cases, relevance was unknown and there was no demonstrable (meth)acrylate allergy. There were no reactions to Carbopol®.</p><p><strong>Conclusions: </strong>Sensitisation to these concentrations of the three tested ACPs is rare. Elicitation of dermatitis in (meth)acrylate-sensitised patients by exposure to these three ACPs appears unlikely.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renato Ivan de Ávila, Linda Ljungberg Silic, Sofía Carreira-Santos, Gábor Merényi, Ola Bergendorff, Kathrin S Zeller
Background: Allergic contact dermatitis (ACD) from protective gloves is often caused by rubber additives, such as accelerators. However, while accelerator-free rubber gloves are available, they still cause ACD in some individuals.
Objectives: A new allergen, 2-cyаnоethyl dimethyldithiocarbamate, (CEDMC), has recently been identified in accelerator-free gloves, and we here provide a first in vitro characterisation of CEDMC in a dendritic cell (DC)-like cell model along with three reference sensitizer rubber chemicals, consisting of tetraethylthiuram disulfide (TETD) and two xanthogenates.
Methods: Cellular responses after the exposure to the rubber chemicals were assessed using a transcriptomic approach, multiplex cytokine secretion profiling, and flow cytometry to determine DC model activation marker expression and apoptosis induction.
Results: CEDMC and all other sensitizers were classified as strong skin sensitizers with the transcriptomic approach. They all significantly increased IL-8 secretion and exposure to all except one increased CD86 DC activation marker expression. When tested, CEDMC induced apoptosis, however, delayed compared to TETD.
Conclusions: The in vitro data corroborate CEDMC, TETD, and investigated xanthogenates as skin sensitizers. Transcriptomic analyses further reveal unique cellular responses induced by CEDMC, which together with future study can contribute to better understanding of cellular mechanisms underlying the sensitising capacity of rubber chemicals.
背景:防护手套引起的过敏性接触性皮炎(ACD)通常是由橡胶添加剂(如促进剂)引起的。然而,虽然现在有了不含促进剂的橡胶手套,但它们仍会导致一些人出现过敏性接触性皮炎:目的:最近在无促进剂手套中发现了一种新的过敏原--2-氰基о乙基二甲基二硫代氨基甲酸酯(CEDMC),我们在此首次在树突状细胞(DC)样细胞模型中对 CEDMC 以及三种参考致敏橡胶化学物质(包括二硫化四乙基秋兰姆(TETD)和两种黄原酸盐)进行了体外表征:方法:采用转录组学方法、多重细胞因子分泌谱分析和流式细胞术评估暴露于橡胶化学品后的细胞反应,以确定 DC 模型活化标志物的表达和凋亡诱导:结果:通过转录组学方法,CEDMC 和所有其他致敏剂都被归类为强皮肤致敏剂。它们都能明显增加 IL-8 的分泌,而且除一种外,接触其他所有致敏剂都能增加 CD86 DC 激活标记物的表达。经测试,CEDMC可诱导细胞凋亡,但与TETD相比有所延迟:体外数据证实了 CEDMC、TETD 和经研究的黄原酸盐是皮肤致敏物质。转录组分析进一步揭示了 CEDMC 所诱导的独特细胞反应,这些反应以及未来的研究将有助于更好地了解橡胶化学品致敏能力的细胞机制。
{"title":"In vitro characterisation of a novel rubber contact allergen in protective gloves.","authors":"Renato Ivan de Ávila, Linda Ljungberg Silic, Sofía Carreira-Santos, Gábor Merényi, Ola Bergendorff, Kathrin S Zeller","doi":"10.1111/cod.14682","DOIUrl":"https://doi.org/10.1111/cod.14682","url":null,"abstract":"<p><strong>Background: </strong>Allergic contact dermatitis (ACD) from protective gloves is often caused by rubber additives, such as accelerators. However, while accelerator-free rubber gloves are available, they still cause ACD in some individuals.</p><p><strong>Objectives: </strong>A new allergen, 2-cyаnоethyl dimethyldithiocarbamate, (CEDMC), has recently been identified in accelerator-free gloves, and we here provide a first in vitro characterisation of CEDMC in a dendritic cell (DC)-like cell model along with three reference sensitizer rubber chemicals, consisting of tetraethylthiuram disulfide (TETD) and two xanthogenates.</p><p><strong>Methods: </strong>Cellular responses after the exposure to the rubber chemicals were assessed using a transcriptomic approach, multiplex cytokine secretion profiling, and flow cytometry to determine DC model activation marker expression and apoptosis induction.</p><p><strong>Results: </strong>CEDMC and all other sensitizers were classified as strong skin sensitizers with the transcriptomic approach. They all significantly increased IL-8 secretion and exposure to all except one increased CD86 DC activation marker expression. When tested, CEDMC induced apoptosis, however, delayed compared to TETD.</p><p><strong>Conclusions: </strong>The in vitro data corroborate CEDMC, TETD, and investigated xanthogenates as skin sensitizers. Transcriptomic analyses further reveal unique cellular responses induced by CEDMC, which together with future study can contribute to better understanding of cellular mechanisms underlying the sensitising capacity of rubber chemicals.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D Hilewitz, A Trattner, O Reiter, V Uvaidov, Y Noyman, E Solomon Cohen, A Hackett, D Mimouni, I Snast
Background: 2-Hydroxyethyl methacrylate (HEMA) was added into the European baseline series (EBS) in 2019. There is limited data regarding the frequency, relevance, and sources of exposure to HEMA.
Objectives: To investigate the frequency and clinical relevance of positive reactions to HEMA in the EBS in Israel, and explore sources of exposure.
Methods: Retrospective cohort study that included all patients who underwent patch testing with the EBS in a tertiary center in Israel between 2020 and 2023. Positive reactions to HEMA were stratified by sex, six age groups, and year of study. Sources of exposure to HEMA as well as occupational data were recorded.
Results: A total of 1671 consecutive patients underwent HEMA patch testing, with 135 (8.1%) showing positive reactions to HEMA (130 females, 5 males). The prevalence in women (11.0%) was significantly higher compared to men (1.0%) (p < 0.001). Stratification by age and sex revealed the highest frequency of HEMA sensitivity of 16.7% among women younger than 30 years of age, with odds ratio of 2.3 (95%CI: 1.6-3.3, p < 0.001) compared to older women. There was an increase in frequency among women between the years 2022 and 2023 when compared to 2020-2021 (OR 1.7, 95%CI: 1.5-2.1, p < 0.01) attributable to COVID-19 pandemic and social restrictions. Among men the frequency fluctuations over the study period and age categories were nonsignificant. 111 (84%) were judged to be of clinical relevance and nail cosmetics was responsible for 95% of them. Of 111 patients with relevant reaction (110 females, 1 males), 20 (18%) had occupational contact dermatitis (18 nails stylists, 2 dentists). Other culprit products included sanitary pads (n = 4), medical adhesives (n = 3), and paints (n = 2).
Conclusion: We report the highest frequency of HEMA sensitivity to date of 8.1%, that was most common among young women and in vast majority of cases was attributable to nail cosmetics. Our findings reflect the popularity of nail cosmetics in Israel as well as the global trend of increasing sensitivity to (meth)acrylates.
背景:2-羟乙基甲基丙烯酸酯(HEMA)于 2019 年被纳入欧洲基线系列(EBS)。有关接触 HEMA 的频率、相关性和来源的数据有限:调查以色列 EBS 中 HEMA 阳性反应的频率和临床相关性,并探索暴露来源:回顾性队列研究纳入了 2020 年至 2023 年期间在以色列一家三级中心接受 EBS 贴片测试的所有患者。按性别、六个年龄组和研究年份对 HEMA 阳性反应进行分层。研究还记录了接触 HEMA 的来源以及职业数据:共有 1671 名患者接受了 HEMA 贴片测试,其中 135 人(8.1%)对 HEMA 呈阳性反应(女性 130 人,男性 5 人)。与男性(1.0%)相比,女性(11.0%)的发病率明显更高(P 结论:我们报告的 HEMA 阳性反应发生率最高:我们报告了迄今为止对 HEMA 敏感的最高频率(8.1%),这在年轻女性中最为常见,而且绝大多数病例都可归因于美甲化妆品。我们的研究结果反映了美甲化妆品在以色列的普及程度,以及全球对(甲基)丙烯酸酯的敏感性不断增加的趋势。
{"title":"Pandemic of sensitivity to acrylate containing nail cosmetic among young Israeli women? Result of patch testing 2-hydroxyethyl methacrylate in the European baseline series.","authors":"D Hilewitz, A Trattner, O Reiter, V Uvaidov, Y Noyman, E Solomon Cohen, A Hackett, D Mimouni, I Snast","doi":"10.1111/cod.14683","DOIUrl":"https://doi.org/10.1111/cod.14683","url":null,"abstract":"<p><strong>Background: </strong>2-Hydroxyethyl methacrylate (HEMA) was added into the European baseline series (EBS) in 2019. There is limited data regarding the frequency, relevance, and sources of exposure to HEMA.</p><p><strong>Objectives: </strong>To investigate the frequency and clinical relevance of positive reactions to HEMA in the EBS in Israel, and explore sources of exposure.</p><p><strong>Methods: </strong>Retrospective cohort study that included all patients who underwent patch testing with the EBS in a tertiary center in Israel between 2020 and 2023. Positive reactions to HEMA were stratified by sex, six age groups, and year of study. Sources of exposure to HEMA as well as occupational data were recorded.</p><p><strong>Results: </strong>A total of 1671 consecutive patients underwent HEMA patch testing, with 135 (8.1%) showing positive reactions to HEMA (130 females, 5 males). The prevalence in women (11.0%) was significantly higher compared to men (1.0%) (p < 0.001). Stratification by age and sex revealed the highest frequency of HEMA sensitivity of 16.7% among women younger than 30 years of age, with odds ratio of 2.3 (95%CI: 1.6-3.3, p < 0.001) compared to older women. There was an increase in frequency among women between the years 2022 and 2023 when compared to 2020-2021 (OR 1.7, 95%CI: 1.5-2.1, p < 0.01) attributable to COVID-19 pandemic and social restrictions. Among men the frequency fluctuations over the study period and age categories were nonsignificant. 111 (84%) were judged to be of clinical relevance and nail cosmetics was responsible for 95% of them. Of 111 patients with relevant reaction (110 females, 1 males), 20 (18%) had occupational contact dermatitis (18 nails stylists, 2 dentists). Other culprit products included sanitary pads (n = 4), medical adhesives (n = 3), and paints (n = 2).</p><p><strong>Conclusion: </strong>We report the highest frequency of HEMA sensitivity to date of 8.1%, that was most common among young women and in vast majority of cases was attributable to nail cosmetics. Our findings reflect the popularity of nail cosmetics in Israel as well as the global trend of increasing sensitivity to (meth)acrylates.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincent A DeLeo, Brandon L Adler, Donald V Belsito, Melanie D Pratt, Denis Sasseville, Margo J Reeder, Erin M Warshaw, Amber R Atwater, James S Taylor, Frances Storrs, James G Marks, Joel G DeKoven, Jonathan Silverberg, JiaDe Yu, Nina Botto, Marie-Claude Houle, Christen M Mowad, Cory A Dunnick
Background: Photoallergic contact dermatitis (PACD) is a delayed hypersensitivity reaction to allergens only in the presence of ultraviolet radiation in sunlight. Photopatch testing (PhotoPT) is necessary to confirm the diagnosis of PACD. There are few published studies of PhotoPT in North America.
Objective: To summarise the results of patients photopatch tested by members of the North American Contact Dermatitis Group (NACDG), 2009-2020.
Methods: Retrospective analysis of patient characteristics and PhotoPT results to 32 allergens on the NACDG Photopatch Test Series.
Results: Most of the 454 tested patients were female (70.3%), 21-60 years old (66.7%) and White (66.7%). There were a total of 119 positive photopatch tests. Sunscreen agents comprised 88.2% of those, with benzophenones responsible for over half of them. Final diagnoses included PACD in 17.2%, allergic contact dermatitis (ACD) in 44.5%, polymorphous light eruption (PMLE) in 18.9% and chronic actinic dermatitis (CAD) in 9.0% of patients.
Conclusions: In 454 patients with suspected photosensitivity referred for photopatch testing in North America, approximately one-fifth had PACD. Sunscreen agents, especially benzophenones, were the most common photoallergens. Other common diagnoses included ACD, PMLE and CAD. Photopatch testing is an important tool for differentiating these conditions.
{"title":"Photopatch testing: Clinical characteristics, test results, and final diagnoses from the North American Contact Dermatitis Group, 2009-2020.","authors":"Vincent A DeLeo, Brandon L Adler, Donald V Belsito, Melanie D Pratt, Denis Sasseville, Margo J Reeder, Erin M Warshaw, Amber R Atwater, James S Taylor, Frances Storrs, James G Marks, Joel G DeKoven, Jonathan Silverberg, JiaDe Yu, Nina Botto, Marie-Claude Houle, Christen M Mowad, Cory A Dunnick","doi":"10.1111/cod.14677","DOIUrl":"https://doi.org/10.1111/cod.14677","url":null,"abstract":"<p><strong>Background: </strong>Photoallergic contact dermatitis (PACD) is a delayed hypersensitivity reaction to allergens only in the presence of ultraviolet radiation in sunlight. Photopatch testing (PhotoPT) is necessary to confirm the diagnosis of PACD. There are few published studies of PhotoPT in North America.</p><p><strong>Objective: </strong>To summarise the results of patients photopatch tested by members of the North American Contact Dermatitis Group (NACDG), 2009-2020.</p><p><strong>Methods: </strong>Retrospective analysis of patient characteristics and PhotoPT results to 32 allergens on the NACDG Photopatch Test Series.</p><p><strong>Results: </strong>Most of the 454 tested patients were female (70.3%), 21-60 years old (66.7%) and White (66.7%). There were a total of 119 positive photopatch tests. Sunscreen agents comprised 88.2% of those, with benzophenones responsible for over half of them. Final diagnoses included PACD in 17.2%, allergic contact dermatitis (ACD) in 44.5%, polymorphous light eruption (PMLE) in 18.9% and chronic actinic dermatitis (CAD) in 9.0% of patients.</p><p><strong>Conclusions: </strong>In 454 patients with suspected photosensitivity referred for photopatch testing in North America, approximately one-fifth had PACD. Sunscreen agents, especially benzophenones, were the most common photoallergens. Other common diagnoses included ACD, PMLE and CAD. Photopatch testing is an important tool for differentiating these conditions.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gizem Kocabas, Norbertus A Ipenburg, Anton de Groot, Thomas Rustemeyer
Background: Propolis was added to the European baseline series (EBS) in 2019.
Objectives: To investigate the frequency and relevance of positive patch tests to propolis in the EBS and to study co-reactivities.
Patients and methods: Retrospective study in patients patch tested between June 2019 and November 2023 in a university hospital in Amsterdam, The Netherlands.
Results: Of 3134 consecutive patients, 299 (9.5%) had a positive reaction to propolis 10% pet. Only nine reactions (3%) were judged to be clinically relevant. There were significant co-reactivities to Myroxylon pereirae resin (balsam of Peru), colophonium, fragrance mixes 1 and 2, and to limonene and linalool hydroperoxides. A steep increase in rates of positive reactions to propolis was observed from 2020 to 2023. This was highly likely the result of the replacement of Chinese propolis with Brazilian propolis by the manufacturer.
Conclusions: Positive patch tests for propolis are very frequent in Amsterdam, but only a few of these reactions are relevant. Most are probably (pseudo-)cross-reactions in patients with fragrance allergies. Propolis in the EBS has very limited value for dermatologists and patients in The Netherlands. Changes in patch test materials should be provided to all users to avoid misinterpretation of patch test results.
{"title":"Results of patch testing propolis in the European baseline series: A 4-year retrospective study.","authors":"Gizem Kocabas, Norbertus A Ipenburg, Anton de Groot, Thomas Rustemeyer","doi":"10.1111/cod.14678","DOIUrl":"https://doi.org/10.1111/cod.14678","url":null,"abstract":"<p><strong>Background: </strong>Propolis was added to the European baseline series (EBS) in 2019.</p><p><strong>Objectives: </strong>To investigate the frequency and relevance of positive patch tests to propolis in the EBS and to study co-reactivities.</p><p><strong>Patients and methods: </strong>Retrospective study in patients patch tested between June 2019 and November 2023 in a university hospital in Amsterdam, The Netherlands.</p><p><strong>Results: </strong>Of 3134 consecutive patients, 299 (9.5%) had a positive reaction to propolis 10% pet. Only nine reactions (3%) were judged to be clinically relevant. There were significant co-reactivities to Myroxylon pereirae resin (balsam of Peru), colophonium, fragrance mixes 1 and 2, and to limonene and linalool hydroperoxides. A steep increase in rates of positive reactions to propolis was observed from 2020 to 2023. This was highly likely the result of the replacement of Chinese propolis with Brazilian propolis by the manufacturer.</p><p><strong>Conclusions: </strong>Positive patch tests for propolis are very frequent in Amsterdam, but only a few of these reactions are relevant. Most are probably (pseudo-)cross-reactions in patients with fragrance allergies. Propolis in the EBS has very limited value for dermatologists and patients in The Netherlands. Changes in patch test materials should be provided to all users to avoid misinterpretation of patch test results.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}