Christoffer Kursawe Larsen, Mikkel Bak Jensen, Jakob F B Schwensen
{"title":"Contact allergy to textile dye mix in consecutively patch tested Danish eczema patients: An observational study with historical data from 2015 to 2023.","authors":"Christoffer Kursawe Larsen, Mikkel Bak Jensen, Jakob F B Schwensen","doi":"10.1111/cod.14640","DOIUrl":"https://doi.org/10.1111/cod.14640","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Symmetric drug-related intertriginous and flexural exanthema elicited by lidocaine cum adrenaline in a patient allergic to sodium metabisulfite.","authors":"Emilia Dik, Elisabeth Bjorvatn, Jesper Elberling","doi":"10.1111/cod.14636","DOIUrl":"https://doi.org/10.1111/cod.14636","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disperse violet 17 is a new contact allergen in spectacle frames.","authors":"Hitoshi Miyazawa, Kazumi Sasaki, Mitsuru Numata","doi":"10.1111/cod.14635","DOIUrl":"https://doi.org/10.1111/cod.14635","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikolaj Menné Bonefeld, Torkil Menné, Ulrik Ahrensbøll-Friis, Anne-Sofie Østergaard Gadsbøll, Christian William Wang, Thor Grundtvig Theander, Elisante John Masenga, Daudi Mavura, Herielly Msuya, Michael Fokuo Ofori, Henrik Kløverpris, Niels Ødum, Charlotte Menné Bonefeld, Carsten Geisler
{"title":"High content of hexavalent chromium in cement samples from three African countries.","authors":"Nikolaj Menné Bonefeld, Torkil Menné, Ulrik Ahrensbøll-Friis, Anne-Sofie Østergaard Gadsbøll, Christian William Wang, Thor Grundtvig Theander, Elisante John Masenga, Daudi Mavura, Herielly Msuya, Michael Fokuo Ofori, Henrik Kløverpris, Niels Ødum, Charlotte Menné Bonefeld, Carsten Geisler","doi":"10.1111/cod.14638","DOIUrl":"https://doi.org/10.1111/cod.14638","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pedro Mercader-García, Juan Francisco Silvestre, Francisco Jose Navarro-Triviño, Ana María Giménez-Arnau, María Antonia Pastor-Nieto, Susana Cordoba-Guijarro, Gemma Melé-Ninot, Fátima Tous-Romero, Ricardo González-Pérez, Inmaculada Ruiz-González, Javier Sánchez-Pérez, María Elena Gática-Ortega, Paloma Sánchez-Pedreño, Javier Miquel-Miquel, Javier Ortiz-Frutos, Jose Manuel Carrascosa, Esther Serra-Baldrich, Tatiana Sanz-Sánchez, Victoriano Soria-Aledo, Andrés Carrillo, Leopoldo Borrego, the REIDAC
Background
Budesonide and tixocortol pivalate as markers of contact allergy to corticosteroids have been questioned, as they are not able to detect a significant percentage of allergic patients.
Objectives
To investigate the potential role of clobetasol propionate in enhancing corticosteroid sensitisation detection.
Methods
Between January 2022 and December 2023, patients who attended centres involved in the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy were tested with an extended baseline series that included budesonide, tixocortol pivalate, clobetasol propionate 0.1% in ethanol and 1% in petrolatum.
Results
A total of 4338 patients were tested. Twenty-four patients were allergic to budesonide (0.55%, 95% CI: 0.37–0.82); nine patients were allergic to tixocortol pivalate (0.21%, 95% CI: 0.11–0.39); and 23 patients were allergic to clobetasol (0.53%, 95% CI: 0.35–0.79). Only four of those patients allergic to clobetasol were detected by budesonide and one by tixocortol pivalate. No significant differences in the number of positive tests were found between clobetasol in petrolatum or ethanol.
Conclusions
In Spain budesonide remains the main corticosteroid allergy marker whereas the role of tixocortol pivalate is questionable. The addition of clobetasol propionate to the Spanish baseline series would improve the ability to detect patients allergic to corticosteroids.
{"title":"A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series: Clobetasol propionate in the spotlight","authors":"Pedro Mercader-García, Juan Francisco Silvestre, Francisco Jose Navarro-Triviño, Ana María Giménez-Arnau, María Antonia Pastor-Nieto, Susana Cordoba-Guijarro, Gemma Melé-Ninot, Fátima Tous-Romero, Ricardo González-Pérez, Inmaculada Ruiz-González, Javier Sánchez-Pérez, María Elena Gática-Ortega, Paloma Sánchez-Pedreño, Javier Miquel-Miquel, Javier Ortiz-Frutos, Jose Manuel Carrascosa, Esther Serra-Baldrich, Tatiana Sanz-Sánchez, Victoriano Soria-Aledo, Andrés Carrillo, Leopoldo Borrego, the REIDAC","doi":"10.1111/cod.14639","DOIUrl":"10.1111/cod.14639","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Budesonide and tixocortol pivalate as markers of contact allergy to corticosteroids have been questioned, as they are not able to detect a significant percentage of allergic patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the potential role of clobetasol propionate in enhancing corticosteroid sensitisation detection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Between January 2022 and December 2023, patients who attended centres involved in the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy were tested with an extended baseline series that included budesonide, tixocortol pivalate, clobetasol propionate 0.1% in ethanol and 1% in petrolatum.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 4338 patients were tested. Twenty-four patients were allergic to budesonide (0.55%, 95% CI: 0.37–0.82); nine patients were allergic to tixocortol pivalate (0.21%, 95% CI: 0.11–0.39); and 23 patients were allergic to clobetasol (0.53%, 95% CI: 0.35–0.79). Only four of those patients allergic to clobetasol were detected by budesonide and one by tixocortol pivalate. No significant differences in the number of positive tests were found between clobetasol in petrolatum or ethanol.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In Spain budesonide remains the main corticosteroid allergy marker whereas the role of tixocortol pivalate is questionable. The addition of clobetasol propionate to the Spanish baseline series would improve the ability to detect patients allergic to corticosteroids.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14639","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elena Beatriz Sanz-Cabanillas, Lucía de Dulanto-García, Álvaro Prados-Carmona, Francisco J. Navarro-Triviño
{"title":"Comment response in: ‘Systemic allergic contact dermatitis after use of topical nitrofurazone’","authors":"Elena Beatriz Sanz-Cabanillas, Lucía de Dulanto-García, Álvaro Prados-Carmona, Francisco J. Navarro-Triviño","doi":"10.1111/cod.14634","DOIUrl":"10.1111/cod.14634","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristiina Aalto-Korte, Maria Pesonen, Sari Suomela, Katri Suuronen
Background
Isocyanates are used as starting materials of polyurethane (PU) products. They are relatively important occupational skin sensitizers.
Objectives
To analyse results of a large isocyanate patch test series of 19 isocyanate test substances and 4,4′-diaminodiphenylmethane (MDA), a marker of 4,4′-diphenylmethane diisocyanate (MDI) hypersensitivity.
Methods
Test files were screened for positive reactions in the isocyanate series. Patients with positive reactions were analysed for occupation, exposure and diagnosis.
Results
In 2010–2019, 53 patients had positive reactions in the series (16% of 338 patients tested). MDA, the well-established screening substance for MDI allergy, was positive in 30 patients, an in-house monomeric MDI test substance in 23 patients and 3 different polymeric MDI test substances in 19–21 patients. We diagnosed 16 cases of occupational allergic contact dermatitis (OACD) from MDI including 3 pipe reliners. Hexamethylene-1,6-diisocyanate (HDI) oligomers in paint hardeners caused 5 cases of OACD, more cases than 2,4-toluene diisocyanate (TDI; n = 3) and isophorone diisocyanate (IPDI; n = 1) put together.
Conclusions
In contrast to previous studies, polymeric MDI test substances were not superior to a monomeric MDI. Pipe reliners may get sensitised not only by epoxy products and acrylates but also by MDI in hardeners of PU pipe coatings. HDI oligomers were the second most important causes of OACD after MDI.
{"title":"Nine years of patch testing with isocyanates in a clinic of occupational dermatology","authors":"Kristiina Aalto-Korte, Maria Pesonen, Sari Suomela, Katri Suuronen","doi":"10.1111/cod.14621","DOIUrl":"10.1111/cod.14621","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Isocyanates are used as starting materials of polyurethane (PU) products. They are relatively important occupational skin sensitizers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To analyse results of a large isocyanate patch test series of 19 isocyanate test substances and 4,4′-diaminodiphenylmethane (MDA), a marker of 4,4′-diphenylmethane diisocyanate (MDI) hypersensitivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Test files were screened for positive reactions in the isocyanate series. Patients with positive reactions were analysed for occupation, exposure and diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In 2010–2019, 53 patients had positive reactions in the series (16% of 338 patients tested). MDA, the well-established screening substance for MDI allergy, was positive in 30 patients, an in-house monomeric MDI test substance in 23 patients and 3 different polymeric MDI test substances in 19–21 patients. We diagnosed 16 cases of occupational allergic contact dermatitis (OACD) from MDI including 3 pipe reliners. Hexamethylene-1,6-diisocyanate (HDI) oligomers in paint hardeners caused 5 cases of OACD, more cases than 2,4-toluene diisocyanate (TDI; <i>n</i> = 3) and isophorone diisocyanate (IPDI; <i>n</i> = 1) put together.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In contrast to previous studies, polymeric MDI test substances were not superior to a monomeric MDI. Pipe reliners may get sensitised not only by epoxy products and acrylates but also by MDI in hardeners of PU pipe coatings. HDI oligomers were the second most important causes of OACD after MDI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofia Botvid, Niels H. Bennike, Anne Birgitte Simonsen, Jeanne Duus Johansen, Wolfgang Uter
Background
Fragrance substances are a frequent cause of contact allergy worldwide. Fragrance exposure varies by sex, age and possibly country, influenced by cosmetic availability, environmental conditions and cultural practices.
Objectives
To systematically review and gather prevalence of sensitization to fragrance mix I (FM I) and fragrance mix II (FM II) in consecutively patch tested European dermatitis patients.
Method
A total of 4134 publications on patch test results of European dermatitis patients, published from 1981 to 2022, were systematically reviewed according to a previously registered and published PROSPERO protocol.
Results
Eighty-four eligible original articles were analysed. Overall prevalence of sensitization to fragrance mix I (FM I) was 6.81% (95% CI: 6.37–7.28), and FM II was 3.64% (95% CI: 3.3–4.01). Sensitization to FM I was most prevalent in Central and Eastern Europe and to FM II in Western Europe. No clear time trends were observed. Among paediatric dermatitis patients, sensitization prevalence for FM I and FM II was 4.09% (95% CI: 3.37–4.96) and 2.17% (95% CI: 1.53–3.07).
Conclusion
The frequency of positive patch test results for both FMI and FMII remains high. Sensitization is also prevalent among children. Enhanced regulation and labelling of cosmetic products play a vital role in averting exposure and sensitization to fragrance allergens.
背景：香料物质是全球接触性过敏的常见原因。受化妆品供应、环境条件和文化习俗的影响，不同性别、年龄以及可能不同国家的人接触香料的情况各不相同：系统回顾并收集欧洲皮炎患者在连续贴片测试中对混合香料 I（FM I）和混合香料 II（FM II）过敏的流行率：方法：根据先前注册和发布的 PROSPERO 协议，系统审查了 1981 年至 2022 年间发表的有关欧洲皮炎患者贴片测试结果的 4134 篇文献：结果：对 84 篇符合条件的原创文章进行了分析。对混合香料 I（FM I）过敏的总发病率为 6.81%（95% CI：6.37-7.28），对混合香料 II 过敏的总发病率为 3.64%（95% CI：3.3-4.01）。中欧和东欧对 FM I 最敏感，西欧对 FM II 最敏感。没有观察到明显的时间趋势。在儿童皮炎患者中，FM I 和 FM II 的致敏率分别为 4.09% (95% CI: 3.37-4.96) 和 2.17% (95% CI: 1.53-3.07)：FMI 和 FMII 的贴片测试结果呈阳性的频率仍然很高。致敏现象在儿童中也很普遍。加强化妆品的监管和标签对于避免接触香料过敏原和对其过敏起着至关重要的作用。
{"title":"Contact sensitization to fragrance mix I and fragrance mix II among European dermatitis patients: A systematic review","authors":"Sofia Botvid, Niels H. Bennike, Anne Birgitte Simonsen, Jeanne Duus Johansen, Wolfgang Uter","doi":"10.1111/cod.14618","DOIUrl":"10.1111/cod.14618","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Fragrance substances are a frequent cause of contact allergy worldwide. Fragrance exposure varies by sex, age and possibly country, influenced by cosmetic availability, environmental conditions and cultural practices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To systematically review and gather prevalence of sensitization to fragrance mix I (FM I) and fragrance mix II (FM II) in consecutively patch tested European dermatitis patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A total of 4134 publications on patch test results of European dermatitis patients, published from 1981 to 2022, were systematically reviewed according to a previously registered and published PROSPERO protocol.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eighty-four eligible original articles were analysed. Overall prevalence of sensitization to fragrance mix I (FM I) was 6.81% (95% CI: 6.37–7.28), and FM II was 3.64% (95% CI: 3.3–4.01). Sensitization to FM I was most prevalent in Central and Eastern Europe and to FM II in Western Europe. No clear time trends were observed. Among paediatric dermatitis patients, sensitization prevalence for FM I and FM II was 4.09% (95% CI: 3.37–4.96) and 2.17% (95% CI: 1.53–3.07).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The frequency of positive patch test results for both FMI and FMII remains high. Sensitization is also prevalent among children. Enhanced regulation and labelling of cosmetic products play a vital role in averting exposure and sensitization to fragrance allergens.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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