Objectives: This investigation was conducted to evaluate and compare the therapeutic effectiveness of Prangos ferulacea vaginal cream with clotrimazole vaginal cream in improving clinical manifestations and laboratory outcomes of vulvovaginal candidiasis.
Methods: The research was conducted as a triple-blind randomized clinical trial involving 111 participants, who were subsequently assigned to intervention and control groups. Individuals in the control group received Clotrimazole vaginal cream, administered intravaginally at a dose of 5 grams per night for one week using an applicator. The intervention arm implemented an equivalent application protocol, with the difference that the formulation consisted of Prangos ferulacea (Jashir) vaginal cream. Clinical symptoms-including itching, burning and discharge-were evaluated with a visual analog scale (VAS) at baseline and following the intervention. Additionally, culture of vaginal secretions was performed to assess microbiological outcomes. All data processing and statistical evaluations were conducted in SPSS, adopting p < 0.05 as the criterion for statistical significance.
Results: Both groups demonstrated a significant reduction in clinical symptoms following the intervention (p < 0.05). The percentage of women with negative cultures increased to 89.1% in the clotrimazole group and 78.6% in the Prangos ferulacea group, as the difference between groups did not reach statistical significance (p = 0.13). The reduction in itching, burning, and discharge was notable in both groups, indicating effective symptom control (p < 0.05).
Conclusion: Prangos ferulacea vaginal cream demonstrated comparable efficacy to clotrimazole in relieving the symptoms and reducing the microbial burden of vulvovaginal candidiasis. Given its herbal origin and antifungal potential, Prangos ferulacea may serve as a natural and well-tolerated alternative or complementary therapy.
{"title":"Candida Vulvovaginitis Treatment: A Comparative Clinical Trial of Clotrimazole and Prangos Ferulacea (Jashir) Vaginal Creams.","authors":"Leila Ghiasi, Fatemeh Goudarzi, Hossein Sadeghi, Maral Gharaghani, Seyedeh Fatemeh Hekmatzadeh","doi":"10.1016/j.ctim.2026.103334","DOIUrl":"https://doi.org/10.1016/j.ctim.2026.103334","url":null,"abstract":"<p><strong>Objectives: </strong>This investigation was conducted to evaluate and compare the therapeutic effectiveness of Prangos ferulacea vaginal cream with clotrimazole vaginal cream in improving clinical manifestations and laboratory outcomes of vulvovaginal candidiasis.</p><p><strong>Methods: </strong>The research was conducted as a triple-blind randomized clinical trial involving 111 participants, who were subsequently assigned to intervention and control groups. Individuals in the control group received Clotrimazole vaginal cream, administered intravaginally at a dose of 5 grams per night for one week using an applicator. The intervention arm implemented an equivalent application protocol, with the difference that the formulation consisted of Prangos ferulacea (Jashir) vaginal cream. Clinical symptoms-including itching, burning and discharge-were evaluated with a visual analog scale (VAS) at baseline and following the intervention. Additionally, culture of vaginal secretions was performed to assess microbiological outcomes. All data processing and statistical evaluations were conducted in SPSS, adopting p < 0.05 as the criterion for statistical significance.</p><p><strong>Results: </strong>Both groups demonstrated a significant reduction in clinical symptoms following the intervention (p < 0.05). The percentage of women with negative cultures increased to 89.1% in the clotrimazole group and 78.6% in the Prangos ferulacea group, as the difference between groups did not reach statistical significance (p = 0.13). The reduction in itching, burning, and discharge was notable in both groups, indicating effective symptom control (p < 0.05).</p><p><strong>Conclusion: </strong>Prangos ferulacea vaginal cream demonstrated comparable efficacy to clotrimazole in relieving the symptoms and reducing the microbial burden of vulvovaginal candidiasis. Given its herbal origin and antifungal potential, Prangos ferulacea may serve as a natural and well-tolerated alternative or complementary therapy.</p>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":" ","pages":"103334"},"PeriodicalIF":3.5,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inflammatory bowel disease (IBD) affects millions worldwide and imposes both physical and psychological burdens. While current treatments have limitations, yoga-based mind-body interventions (YMBIs) show promise in improving symptoms and quality of life through physiological and stress-regulating pathways.
Objective
This Meta-analysis seeks to comprehensively and objectively assess the efficacy of yoga-based mind-body interventions on psychological, physical, and inflammatory outcomes in patients with IBD.
Methods
A comprehensive search was conducted in both international and Chinese databases including PubMed, EMBASE, Cochrane Library, Web of Science, Medline, China National Knowledge Infrastructure (CNKI), WanFang, and China Biomedical Literature Service System. Randomized controlled trials (RCTs) comparing YMBIs with standard care or placebo in IBD patients were pooled from inception to February 17, 2025. Data were analyzed using RevMan 5.4 and Stata 16.0, with standardized mean differences (SMDs) and 95 % confidence intervals (CIs) as effect measures.
Results
Seven RCTs comprising 502 participants were included. The meta-analysis revealed that YMBIs significantly reduced anxiety (SMD = −0.56, 95 % CI [−0.77 to −0.36], P < 0.0001), depression (SMD = −3.45, 95 % CI [−5.52 to −1.37], P < 0.0001), and perceived stress (SMD = −0.70, 95 % CI [−1.00 to −0.39], P < 0.0001), while improving quality of life (SMD = 0.47, 95 % CI [0.17–0.77], P = 0.002). Effects on sleep quality (SMD = −1.98, 95 % CI [−3.98–0.02], P = 0.05) and disease activity (SMD = −0.26, 95 % CI [−0.52–0.01], P = 0.05) were modest, with borderline statistical significance.
Conclusion
YMBIs alleviates psychological distress and enhance well-being in IBD patients, though their impact on disease progression remains uncertain. However, their effects on sleep quality and disease activity require further validation through high-quality clinical studies.
背景：炎症性肠病（IBD）影响着全世界数百万人，并给他们带来身体和心理上的负担。虽然目前的治疗方法有局限性，但基于瑜伽的身心干预（YMBIs）显示出通过生理和压力调节途径改善症状和生活质量的希望。目的：本荟萃分析旨在全面客观地评估基于瑜伽的身心干预对IBD患者心理、身体和炎症结局的疗效。方法：综合检索PubMed、EMBASE、Cochrane Library、Web of Science、Medline、中国知网、万方、中国生物医学文献服务系统等国内外数据库。比较IBD患者中YMBIs与标准治疗或安慰剂的随机对照试验（rct）从开始到2025年2月17日进行汇总。采用RevMan 5.4和Stata 16.0对数据进行分析，以标准化平均差异（SMDs）和95%置信区间（ci）作为效果度量。结果：纳入7项随机对照试验，共502名受试者。荟萃分析显示，YMBIs显著降低了焦虑（SMD = -0.56, 95% CI [-0.77 ~ -0.36], P < 0.0001）、抑郁（SMD = -3.45, 95% CI [-5.52 ~ -1.37], P < 0.0001）和感知压力（SMD = -0.70, 95% CI [-1.00 ~ -0.39], P < 0.0001），同时改善了生活质量（SMD = 0.47, 95% CI [0.17 ~ 0.77], P = 0.002）。对睡眠质量（SMD = -1.98, 95% CI [-3.98 ~ 0.02], P = 0.05）和疾病活动性（SMD = -0.26, 95% CI [-0.52 ~ 0.01], P = 0.05）的影响一般，具有临界统计学意义。结论：YMBIs可减轻IBD患者的心理困扰，提高幸福感，但其对疾病进展的影响尚不确定。然而，它们对睡眠质量和疾病活动的影响需要通过高质量的临床研究进一步验证。系统评审注册：https://www.crd.york.ac.uk/PROSPERO/view/CRD420250653339。
{"title":"Meta-analysis of yoga-based mind-body interventions in the management of inflammatory bowel disease","authors":"Linjia Pan , Xiaotong Chen , Yiqi Wu , Zhanyi Zhou , Daogun Xu","doi":"10.1016/j.ctim.2025.103287","DOIUrl":"10.1016/j.ctim.2025.103287","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory bowel disease (IBD) affects millions worldwide and imposes both physical and psychological burdens. While current treatments have limitations, yoga-based mind-body interventions (YMBIs) show promise in improving symptoms and quality of life through physiological and stress-regulating pathways.</div></div><div><h3>Objective</h3><div>This Meta-analysis seeks to comprehensively and objectively assess the efficacy of yoga-based mind-body interventions on psychological, physical, and inflammatory outcomes in patients with IBD.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in both international and Chinese databases including PubMed, EMBASE, Cochrane Library, Web of Science, Medline, China National Knowledge Infrastructure (CNKI), WanFang, and China Biomedical Literature Service System. Randomized controlled trials (RCTs) comparing YMBIs with standard care or placebo in IBD patients were pooled from inception to February 17, 2025. Data were analyzed using RevMan 5.4 and Stata 16.0, with standardized mean differences (SMDs) and 95 % confidence intervals (CIs) as effect measures.</div></div><div><h3>Results</h3><div>Seven RCTs comprising 502 participants were included. The meta-analysis revealed that YMBIs significantly reduced anxiety (SMD = −0.56, 95 % CI [−0.77 to −0.36], P < 0.0001), depression (SMD = −3.45, 95 % CI [−5.52 to −1.37], P < 0.0001), and perceived stress (SMD = −0.70, 95 % CI [−1.00 to −0.39], P < 0.0001), while improving quality of life (SMD = 0.47, 95 % CI [0.17–0.77], P = 0.002). Effects on sleep quality (SMD = −1.98, 95 % CI [−3.98–0.02], P = 0.05) and disease activity (SMD = −0.26, 95 % CI [−0.52–0.01], P = 0.05) were modest, with borderline statistical significance.</div></div><div><h3>Conclusion</h3><div>YMBIs alleviates psychological distress and enhance well-being in IBD patients, though their impact on disease progression remains uncertain. However, their effects on sleep quality and disease activity require further validation through high-quality clinical studies.</div></div><div><h3>Systematic review registration</h3><div><span><span>https://www.crd.york.ac.uk/PROSPERO/view/CRD420250653339</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103287"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-30DOI: 10.1016/j.ctim.2025.103281
Josiane Bissonnette , Andréanne Côté , Peter-Gens Desameau , Mariève Cossette , Anne Marie Pinard , Caroline Arbour , Gabrielle Fortin , David Ogez , Pierre Rainville
Objectives
To evaluate the preliminary effectiveness of a personalized intervention integrating pre-recorded hypnosis and/or music in palliative and end-of-life care, and explore patient preferences and experiences.
Methods
Forty patients receiving palliative and end-of-life care at home were recruited and randomly assigned to the experimental group or the control/delayed intervention group. Two intervention sessions were conducted within one week, featuring the following modalities tailored to patient preferences: pre-recorded music, hypnosis, or a combination of music and hypnosis. Participants provided self-ratings of their symptoms and distress at predetermined time points using the Edmonton Symptom Assessment Scale and the Distress Thermometer. We used a mixed-effects model to address the quantitative objectives, and we conducted a content analysis to meet the qualitative objectives.
Results
The intervention program significantly reduced participants’ distress, showing a medium effect size when comparing the intervention sessions to the control sessions. We also found a medium effect size for improved well-being between groups. Intervention modality did not appear to affect the responses. Participants reported calmness and well-being. The voluntary use of these interventions post-experiment emphasizes their relevance for palliative and end-of-life care. The qualitative findings were consistent with the quantitative results, and revealed additional potential uses and ways to improve the intervention.
Conclusion
The personalized pre-recorded music and hypnosis interventions appear to be effective in reducing distress and show great potential for enhancing the overall well-being of individuals in palliative and end-of-life care. Further studies are needed to determine how these findings can be applied to a broader population.
{"title":"Personalized music and hypnosis interventions in palliative and end-of-life care at home: A randomized controlled pilot study","authors":"Josiane Bissonnette , Andréanne Côté , Peter-Gens Desameau , Mariève Cossette , Anne Marie Pinard , Caroline Arbour , Gabrielle Fortin , David Ogez , Pierre Rainville","doi":"10.1016/j.ctim.2025.103281","DOIUrl":"10.1016/j.ctim.2025.103281","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the preliminary effectiveness of a personalized intervention integrating pre-recorded hypnosis and/or music in palliative and end-of-life care, and explore patient preferences and experiences.</div></div><div><h3>Methods</h3><div>Forty patients receiving palliative and end-of-life care at home were recruited and randomly assigned to the experimental group or the control/delayed intervention group. Two intervention sessions were conducted within one week, featuring the following modalities tailored to patient preferences: pre-recorded music, hypnosis, or a combination of music and hypnosis. Participants provided self-ratings of their symptoms and distress at predetermined time points using the Edmonton Symptom Assessment Scale and the Distress Thermometer. We used a mixed-effects model to address the quantitative objectives, and we conducted a content analysis to meet the qualitative objectives.</div></div><div><h3>Results</h3><div>The intervention program significantly reduced participants’ distress, showing a medium effect size when comparing the intervention sessions to the control sessions. We also found a medium effect size for improved well-being between groups. Intervention modality did not appear to affect the responses. Participants reported calmness and well-being. The voluntary use of these interventions post-experiment emphasizes their relevance for palliative and end-of-life care. The qualitative findings were consistent with the quantitative results, and revealed additional potential uses and ways to improve the intervention.</div></div><div><h3>Conclusion</h3><div>The personalized pre-recorded music and hypnosis interventions appear to be effective in reducing distress and show great potential for enhancing the overall well-being of individuals in palliative and end-of-life care. Further studies are needed to determine how these findings can be applied to a broader population.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103281"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-28DOI: 10.1016/j.ctim.2025.103276
Yao Chen , Yang Cui , Xinyu Zhou , Shuo Zhang , Ze Wang , Juandi Yang , Xiangxin Zeng , Yuhuai Guo , Zhongren Sun , Hongna Yin
Background
Clinical trials on acupuncture for multiple sclerosis (MS) have been growing, but the findings are ongoing controversy.
Objective
To evaluate the existing randomized clinical trials (RCTs) for evidence of the efficacy of acupuncture on MS.
Methods
We searched PubMed, Embase, CENTRAL, Web of Science, four Chinese-language databases, clinical research registration, gray literature, and reference lists of the selected studies. We evaluated the risk of bias in the included studies with RoB 2, and performed meta-analysis, subgroup analysis, meta-regression, and publication bias detection using STATA version 15.1. Moreover, we assessed the certainty of evidence using the GRADE approach. The protocol for this review was registered with PROSPERO (Prospective Register of Systematic Reviews) (CRD42024530800).
Results
A total of 11 RCTs (with 574 patients) were included in the study. The meta-analysis results showed that acupuncture, when combined with medicine, is more effective at improving disability status and enhancing the quality of life than medicine alone Acupuncture-related adverse events were rare and mild. The evidence grade was generally low because of the substantial heterogeneity among studies.
Conclusions
Acupuncture therapies are potential treatment options for MS, and are relatively safe. However, owing to the limitations of this study, these conclusions should be interpreted with caution.
背景：针灸治疗多发性硬化症（MS）的临床试验越来越多，但研究结果仍存在争议。目的：评价针刺治疗多发性硬化的随机临床试验（rct）。方法：检索PubMed、Embase、CENTRAL、Web of Science、4个中文数据库、临床研究注册、灰色文献和入选研究的参考文献。我们使用RoB 2评估纳入研究的偏倚风险，并使用STATA 15.1版本进行meta分析、亚组分析、meta回归和发表偏倚检测。此外，我们使用GRADE方法评估证据的确定性。本综述的方案已在PROSPERO（前瞻性系统评价注册系统）注册（CRD42024530800）。结果：共纳入11项rct（574例患者）。meta分析结果显示，针灸与药物联合使用在改善残疾状况和提高生活质量方面比单独使用药物更有效，针灸相关不良事件罕见且轻微。由于研究之间存在很大的异质性，证据等级普遍较低。结论：针灸治疗是多发性硬化症的潜在治疗选择，且相对安全。然而，由于本研究的局限性，这些结论应谨慎解释。
{"title":"Clinical evidence on acupuncture for symptom improvement in multiple sclerosis","authors":"Yao Chen , Yang Cui , Xinyu Zhou , Shuo Zhang , Ze Wang , Juandi Yang , Xiangxin Zeng , Yuhuai Guo , Zhongren Sun , Hongna Yin","doi":"10.1016/j.ctim.2025.103276","DOIUrl":"10.1016/j.ctim.2025.103276","url":null,"abstract":"<div><h3>Background</h3><div>Clinical trials on acupuncture for multiple sclerosis (MS) have been growing, but the findings are ongoing controversy.</div></div><div><h3>Objective</h3><div>To evaluate the existing randomized clinical trials (RCTs) for evidence of the efficacy of acupuncture on MS.</div></div><div><h3>Methods</h3><div>We searched PubMed, Embase, CENTRAL, Web of Science, four Chinese-language databases, clinical research registration, gray literature, and reference lists of the selected studies. We evaluated the risk of bias in the included studies with RoB 2, and performed meta-analysis, subgroup analysis, meta-regression, and publication bias detection using STATA version 15.1. Moreover, we assessed the certainty of evidence using the GRADE approach. The protocol for this review was registered with PROSPERO (Prospective Register of Systematic Reviews) (CRD42024530800).</div></div><div><h3>Results</h3><div>A total of 11 RCTs (with 574 patients) were included in the study. The meta-analysis results showed that acupuncture, when combined with medicine, is more effective at improving disability status and enhancing the quality of life than medicine alone Acupuncture-related adverse events were rare and mild. The evidence grade was generally low because of the substantial heterogeneity among studies.</div></div><div><h3>Conclusions</h3><div>Acupuncture therapies are potential treatment options for MS, and are relatively safe. However, owing to the limitations of this study, these conclusions should be interpreted with caution.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103276"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145399970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-15DOI: 10.1016/j.ctim.2025.103263
Qi Yang , Kim Geok Soh , Mohamad Aris Bin Mohd Moklas , Mengjiao Wang , Xiaoyang Pan , Kui Ma
Background
Self-myofascial release (SMR) is widely used by athletes and coaches during warm up and recovery to increase joint range of motion. Its long term effects on performance are less clear.
Objective
To evaluate the chronic effects, defined as at least 4 weeks, of SMR interventions on athletes physical fitness and sport specific performance, focusing on flexibility, strength, balance, and skill execution.
Design
Systematic review.
Data sources
PubMed, SPORTDiscus, Web of Science, and Scopus were searched in February 2025 in line with PRISMA.
Eligibility criteria
Experimental studies in peer reviewed English journals that examined SMR for 4 weeks or longer and reported performance related outcomes in athletes.
Results
Of 1391 records screened, 12 studies met inclusion, totaling 388 athletes aged 12–30 from soccer, tennis, water polo, volleyball, and mixed sports. Most studies reported significant gains in joint mobility, especially hip and shoulder flexibility. Several studies also showed moderate improvements in strength, such as maximal voluntary contraction and jump height, and in dynamic balance measured by the Y-Balance Test. Effects on static balance, isokinetic strength across all planes, and sport specific skills such as serve speed or sprint swimming were variable and often non significant.
Conclusion
Chronic SMR appears effective for improving flexibility and dynamic balance in athletes and may confer additional benefits for strength and motor control. Heterogeneity in protocols, comparators, and outcome measures, along with modest methodological quality, limits firm conclusions. More high quality, sport specific trials are needed to define optimal SMR parameters across training phases.
背景：运动员和教练员在热身和恢复时广泛使用自我肌筋膜释放（SMR）来增加关节活动范围。它对业绩的长期影响尚不清楚。目的：评估SMR干预对运动员身体素质和运动特定表现的慢性影响（定义为至少4周），重点是柔韧性、力量、平衡和技能执行。数据来源：PubMed， SPORTDiscus, Web of Science， Scopus检索时间为2025年2月，与PRISMA一致。入选标准：在同行评议的英文期刊上发表的实验研究，研究了4周或更长时间的SMR，并报告了运动员的表现相关结果。结果：在筛选的1391项记录中，12项研究符合纳入标准，共计388名年龄在12至30岁之间的运动员，分别来自足球、网球、水球、排球和混合运动。大多数研究报告了关节灵活性的显著提高，特别是髋关节和肩部的灵活性。一些研究也显示了力量的适度改善，如最大自主收缩和跳跃高度，以及通过y平衡测试测量的动态平衡。对静态平衡、所有平面的等速力量和运动特定技能（如发球速度或短跑游泳）的影响是可变的，而且往往不显著。结论：慢性SMR似乎对提高运动员的柔韧性和动态平衡是有效的，并且可能对力量和运动控制有额外的好处。方案、比较物和结果测量的异质性，以及适度的方法学质量，限制了确定的结论。需要更多高质量的特定运动试验来定义跨训练阶段的最佳SMR参数。
{"title":"A systematic review of the chronic effects of self-myofascial release on athletic performance","authors":"Qi Yang , Kim Geok Soh , Mohamad Aris Bin Mohd Moklas , Mengjiao Wang , Xiaoyang Pan , Kui Ma","doi":"10.1016/j.ctim.2025.103263","DOIUrl":"10.1016/j.ctim.2025.103263","url":null,"abstract":"<div><h3>Background</h3><div>Self-myofascial release (SMR) is widely used by athletes and coaches during warm up and recovery to increase joint range of motion. Its long term effects on performance are less clear.</div></div><div><h3>Objective</h3><div>To evaluate the chronic effects, defined as at least 4 weeks, of SMR interventions on athletes physical fitness and sport specific performance, focusing on flexibility, strength, balance, and skill execution.</div></div><div><h3>Design</h3><div>Systematic review.</div></div><div><h3>Data sources</h3><div>PubMed, SPORTDiscus, Web of Science, and Scopus were searched in February 2025 in line with PRISMA.</div></div><div><h3>Eligibility criteria</h3><div>Experimental studies in peer reviewed English journals that examined SMR for 4 weeks or longer and reported performance related outcomes in athletes.</div></div><div><h3>Results</h3><div>Of 1391 records screened, 12 studies met inclusion, totaling 388 athletes aged 12–30 from soccer, tennis, water polo, volleyball, and mixed sports. Most studies reported significant gains in joint mobility, especially hip and shoulder flexibility. Several studies also showed moderate improvements in strength, such as maximal voluntary contraction and jump height, and in dynamic balance measured by the Y-Balance Test. Effects on static balance, isokinetic strength across all planes, and sport specific skills such as serve speed or sprint swimming were variable and often non significant.</div></div><div><h3>Conclusion</h3><div>Chronic SMR appears effective for improving flexibility and dynamic balance in athletes and may confer additional benefits for strength and motor control. Heterogeneity in protocols, comparators, and outcome measures, along with modest methodological quality, limits firm conclusions. More high quality, sport specific trials are needed to define optimal SMR parameters across training phases.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103263"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-11-01DOI: 10.1016/j.ctim.2025.103304
Guodong Li , Xinyu Hu , Jingli Xing , Yiying Wang , Chenlu Wang , Wennan Yu , Jie Lian , Huijuan Cao
Objective
To consolidate and analyze the existing evidence on the relationship between acupuncture treatment frequency and its clinical efficacy, clarify research status, trends, and core issues, and provide evidence-based insights for optimizing acupuncture treatment protocols.
Methods
Following the Arksey and O’Malley scoping review framework and PRISMA-ScR guidelines, nine databases were searched from inception to February 15, 2025. Associations among frequency, disease, and effectiveness were visualized using heat maps and bubble charts. Between-group differences (high-frequency: more than 3 sessions/week; low-frequency: no more than 3 sessions/week) and their influencing factors were summarized.
Results
Ninety-four studies were included. There was a significant disease-specific, nonlinear relationship between acupuncture frequency and efficacy. High-frequency acupuncture (> 3 sessions/week) demonstrated marked advantages in treating degenerative spinal/joint diseases, particularly during acute phases or for short-term symptom relief especially. In contrast, peripheral neuropathies showed lower sensitivity to frequency variations. Efficacy enhancement did not depend solely on increased frequency, however. Instead, we found a "J-shaped curve" and plateau effects. Significant interactions existed between frequency and other acupuncture parameters, with their importance varying by disease and treatment goals. The current literature evidence shows significant heterogeneity in its various definitions of treatment frequency, though there is an obvious a paucity of low-frequency studies.
Conclusion
Optimizing acupuncture frequency requires dynamic adjustments based on disease type, pathological stage, primary treatment goals, and synergistic effects with other treatment parameters. Current evidence remains limited by methodological quality and parameter interaction complexity, precluding the definition of a universally "optimal frequency." Future research should prioritize sequential factorial trials, standardized frequency criteria, and enhanced health-economic evaluations to advance the precision of acupuncture therapy.
{"title":"The relationship between the treatment frequency and efficacy of acupuncture: A scoping review of clinical trials","authors":"Guodong Li , Xinyu Hu , Jingli Xing , Yiying Wang , Chenlu Wang , Wennan Yu , Jie Lian , Huijuan Cao","doi":"10.1016/j.ctim.2025.103304","DOIUrl":"10.1016/j.ctim.2025.103304","url":null,"abstract":"<div><h3>Objective</h3><div>To consolidate and analyze the existing evidence on the relationship between acupuncture treatment frequency and its clinical efficacy, clarify research status, trends, and core issues, and provide evidence-based insights for optimizing acupuncture treatment protocols.</div></div><div><h3>Methods</h3><div>Following the Arksey and O’Malley scoping review framework and PRISMA-ScR guidelines, nine databases were searched from inception to February 15, 2025. Associations among frequency, disease, and effectiveness were visualized using heat maps and bubble charts. Between-group differences (high-frequency: more than 3 sessions/week; low-frequency: no more than 3 sessions/week) and their influencing factors were summarized.</div></div><div><h3>Results</h3><div>Ninety-four studies were included. There was a significant disease-specific, nonlinear relationship between acupuncture frequency and efficacy. High-frequency acupuncture (> 3 sessions/week) demonstrated marked advantages in treating degenerative spinal/joint diseases, particularly during acute phases or for short-term symptom relief especially. In contrast, peripheral neuropathies showed lower sensitivity to frequency variations. Efficacy enhancement did not depend solely on increased frequency, however. Instead, we found a \"J-shaped curve\" and plateau effects. Significant interactions existed between frequency and other acupuncture parameters, with their importance varying by disease and treatment goals. The current literature evidence shows significant heterogeneity in its various definitions of treatment frequency, though there is an obvious a paucity of low-frequency studies.</div></div><div><h3>Conclusion</h3><div>Optimizing acupuncture frequency requires dynamic adjustments based on disease type, pathological stage, primary treatment goals, and synergistic effects with other treatment parameters. Current evidence remains limited by methodological quality and parameter interaction complexity, precluding the definition of a universally \"optimal frequency.\" Future research should prioritize sequential factorial trials, standardized frequency criteria, and enhanced health-economic evaluations to advance the precision of acupuncture therapy.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103304"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-11-01DOI: 10.1016/j.ctim.2025.103302
Wang Jiale , Liu Longcheng , Yuan Haisheng , Yu Qiushuang , Ji Xiaodi , Wang Anqi , Zhang Ying , Ma Lihong
Purpose
Percutaneous coronary intervention (PCI) is one of the most important therapies in patients with coronary heart disease (CHD). However, there are still many problems, such as in-stent restenosis, recurrent angina pectoris, postoperative anxiety and depression. Traditional Chinese exercise (TCE) therapies belong to the aerobic exercise of low and medium intensity which movements are soft and the combination of movement and static, which may have a certain efficacy on cardiac rehabilitation of patients after PCI. Therefore, this study systematically reviewed the reported clinical studies of TCE on cardiac rehabilitation in patients after PCI to explore its efficacy and safety.
Methods
We searched for RCTs on patients after PCI in 8 Chinese and English databases from their inception to Aug 2024. We included patients after PCI, with the intervention group receiving TCE (alone and/or combined with conventional treatment and/or exercise) and the control group receiving only conventional treatment and/or exercise. We screened the literatures and extracted the data. And we used the Cochrane “Risk of bias” tool and GRADE tool to assess the quality of studies and evidence. We used RevMan 5.4 to analyze the results.
Results
Fifty-three studies involving 4700 patients after PCI were included. TCE therapy includes Baduanjin, Tai Chi, Wuqinxi and Yi Jinjing. Conventional treatment(CT) included basic drugs, routine nursing, nutritional guidance and psychological intervention. Conventional exercise (CE) included walking, jogging or other aerobic exercise, resistance training, balance and flexibility training. Methodological quality was of high risk of bias in blinding of participants and personnel as well as unclear of bias in blinding of outcome assessment and allocation concealment. Grade evaluation results suggested low or very low quality of evidence. For the incidence of major adverse cardiovascular events rate, left ventricular ejection fraction, NT-ProBNP, six-minute walk distance, left ventricular end diastolic diameter, left ventricular end-systolic diameter, VO2 max, anaerobic threshold, metabolite equivalents, seattle angina questionnaire and short form 36 health survey questionnaire, treatment group is superior to control group (P＜0.05). For VO2 peak, there was no significant difference between the two groups (P＞0.05).
Conclusions
The results of this study showed that TCE may have efficacy in reducing the incidence of MACE, improving the cardiac function, exercise endurance and quality of life of patients after PCI. And the efficacy of the TCE therapy combined with CT and/or CE may be better than that of the CT and/or CE and the safety may be better.
目的：经皮冠状动脉介入治疗（PCI）是治疗冠心病（CHD）的重要手段之一。但仍存在支架内再狭窄、心绞痛复发、术后焦虑、抑郁等问题。中医运动疗法（Traditional Chinese exercise， TCE）属于运动柔和、动静结合的中、低强度有氧运动，对PCI术后患者的心脏康复可能有一定的疗效。因此，本研究系统回顾了已有报道的TCE对PCI术后患者心脏康复的临床研究，探讨其疗效和安全性。方法：在8个中英文数据库中检索PCI术后患者的随机对照试验（rct），时间为建立之日至2024年8月。我们纳入了PCI术后的患者，干预组接受TCE（单独和/或联合常规治疗和/或运动），对照组只接受常规治疗和/或运动。我们筛选文献并提取数据。我们使用Cochrane“偏倚风险”工具和GRADE工具来评估研究和证据的质量。我们使用RevMan 5.4对结果进行分析。结果：纳入53项研究，涉及4700例PCI术后患者。TCE疗法包括八段筋、太极拳、五琴舞、易金经等。常规治疗包括基础药物、常规护理、营养指导和心理干预。常规运动包括散步、慢跑或其他有氧运动、阻力训练、平衡和柔韧性训练。方法学质量在受试者和人员的盲性偏倚风险较高，在结果评估和分配隐藏的盲性偏倚风险不明确。等级评价结果表明证据质量低或极低。在主要心血管不良事件发生率、左室射血分数、NT-ProBNP、6分钟步行距离、左室舒张末期内径、左室收缩末期内径、VO2 max、无氧阈值、代谢物当量、西雅图心绞痛问卷及36健康问卷短表等方面，治疗组均优于对照组（P<0.05）。两组VO2峰值比较，差异无统计学意义（P < 0.05）。结论：本研究结果表明，TCE可能具有降低PCI术后MACE发生率、改善患者心功能、运动耐力和生活质量的作用。TCE联合CT和/或CE治疗的疗效可能优于CT和/或CE治疗，安全性可能更好。
{"title":"Efficacy and safety of traditional Chinese exercises in cardiac rehabilitation of patients after percutaneous coronary intervention: A systematic review and meta-analysis","authors":"Wang Jiale , Liu Longcheng , Yuan Haisheng , Yu Qiushuang , Ji Xiaodi , Wang Anqi , Zhang Ying , Ma Lihong","doi":"10.1016/j.ctim.2025.103302","DOIUrl":"10.1016/j.ctim.2025.103302","url":null,"abstract":"<div><h3>Purpose</h3><div>Percutaneous coronary intervention (PCI) is one of the most important therapies in patients with coronary heart disease (CHD). However, there are still many problems, such as in-stent restenosis, recurrent angina pectoris, postoperative anxiety and depression. Traditional Chinese exercise (TCE) therapies belong to the aerobic exercise of low and medium intensity which movements are soft and the combination of movement and static, which may have a certain efficacy on cardiac rehabilitation of patients after PCI. Therefore, this study systematically reviewed the reported clinical studies of TCE on cardiac rehabilitation in patients after PCI to explore its efficacy and safety.</div></div><div><h3>Methods</h3><div>We searched for RCTs on patients after PCI in 8 Chinese and English databases from their inception to Aug 2024. We included patients after PCI, with the intervention group receiving TCE (alone and/or combined with conventional treatment and/or exercise) and the control group receiving only conventional treatment and/or exercise. We screened the literatures and extracted the data. And we used the Cochrane “Risk of bias” tool and GRADE tool to assess the quality of studies and evidence. We used RevMan 5.4 to analyze the results.</div></div><div><h3>Results</h3><div>Fifty-three studies involving 4700 patients after PCI were included. TCE therapy includes Baduanjin, Tai Chi, Wuqinxi and Yi Jinjing. Conventional treatment(CT) included basic drugs, routine nursing, nutritional guidance and psychological intervention. Conventional exercise (CE) included walking, jogging or other aerobic exercise, resistance training, balance and flexibility training. Methodological quality was of high risk of bias in blinding of participants and personnel as well as unclear of bias in blinding of outcome assessment and allocation concealment. Grade evaluation results suggested low or very low quality of evidence. For the incidence of major adverse cardiovascular events rate, left ventricular ejection fraction, NT-ProBNP, six-minute walk distance, left ventricular end diastolic diameter, left ventricular end-systolic diameter, VO<sub>2</sub> max, anaerobic threshold, metabolite equivalents, seattle angina questionnaire and short form 36 health survey questionnaire, treatment group is superior to control group (P＜0.05). For VO<sub>2</sub> peak, there was no significant difference between the two groups (P＞0.05).</div></div><div><h3>Conclusions</h3><div>The results of this study showed that TCE may have efficacy in reducing the incidence of MACE, improving the cardiac function, exercise endurance and quality of life of patients after PCI. And the efficacy of the TCE therapy combined with CT and/or CE may be better than that of the CT and/or CE and the safety may be better.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103302"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-30DOI: 10.1016/j.ctim.2025.103277
Jing Xu , Runqing Lin , Aijia Zhang , Qiang Chen , Dexin Li , Jiajie Chen , Minglu Song , Shumei Chen , Bingjiao Yang , Linyang Li , Haotian Xu , Jinlin Peng , Yanrong Tang , Wenhua Yang , Xuexing Luo , Xiang Zhou , Jue Wang , Guanghui Huang
{"title":"Corrigendum to “AI-assisted drawing therapy for children with ADHD: A randomised controlled trial” [Complement Ther Med 94 (2025) 103262]","authors":"Jing Xu , Runqing Lin , Aijia Zhang , Qiang Chen , Dexin Li , Jiajie Chen , Minglu Song , Shumei Chen , Bingjiao Yang , Linyang Li , Haotian Xu , Jinlin Peng , Yanrong Tang , Wenhua Yang , Xuexing Luo , Xiang Zhou , Jue Wang , Guanghui Huang","doi":"10.1016/j.ctim.2025.103277","DOIUrl":"10.1016/j.ctim.2025.103277","url":null,"abstract":"","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103277"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-13DOI: 10.1016/j.ctim.2025.103259
Yue Yin , Zouqin Huang , Yuxia Li , Yi Chen , Ke Cheng , Haiping Deng , Weibo Lv , Yan Wang , Xueyong Shen , Ling Zhao , Lin Lin
Objective
To observe the clinical effects of 10.6-μm laser moxibustion (LM) on diabetic peripheral neuropathy (DPN) and quality of life in patients.
Methods
Sixty-eight patients with DPN were randomly assigned to two groups in a 1:1 ratio and received LM or sham LM 3 times/week for a total of 12 treatments. Outcome parameters were assessed at baseline, at Weeks 2 and 4 of treatment, and at 4 and 8 weeks post-treatment (Weeks 8 and 12) using Michigan Neuropathy Screening Instrument (MNSI) and Diabetes-Specific Quality of Life (DSQL) scores, nerve conduction velocity (NCV), and blood rheology parameters.
Results
Most (58/68) patients completed the trial. MNSI scores were significantly lower at every time point (P < 0.01), and DSQL scores were significantly lower at Weeks 4, 8, and 12 (P < 0.001), compared with baseline in both groups. The LM group had lower MNSI scores at Week 4 (P < 0.05), and lower DSQL scores at Weeks 4, 8, and 12 (P < 0.05) compared with the sham LM group. At Week 4, there was no significant between-group difference in NCV (P > 0.05). Post-treatment, there were no significant differences in blood rheology parameters compared with baseline within each group (P > 0.05). Whole blood high-shear reductive viscosity and red blood cell rigidity index were significantly lower in the LM group than in the sham LM group (P < 0.01). No serious adverse events were recorded.
Conclusion
Treatment with 10.6-μm LM improved clinical symptoms and quality of life in patients with DPN.
Clinical Trial Registration
Chinese Clinical Trial Registry, ChiCTR2000029329. Registered 25 January 2020, https://www.chictr.org.cn/showproj.html?proj=48490
{"title":"Effectiveness of 10.6-μm laser therapy for diabetic peripheral neuropathy: A double-blind, randomized controlled trial","authors":"Yue Yin , Zouqin Huang , Yuxia Li , Yi Chen , Ke Cheng , Haiping Deng , Weibo Lv , Yan Wang , Xueyong Shen , Ling Zhao , Lin Lin","doi":"10.1016/j.ctim.2025.103259","DOIUrl":"10.1016/j.ctim.2025.103259","url":null,"abstract":"<div><h3>Objective</h3><div>To observe the clinical effects of 10.6-μm laser moxibustion (LM) on diabetic peripheral neuropathy (DPN) and quality of life in patients.</div></div><div><h3>Methods</h3><div>Sixty-eight patients with DPN were randomly assigned to two groups in a 1:1 ratio and received LM or sham LM 3 times/week for a total of 12 treatments. Outcome parameters were assessed at baseline, at Weeks 2 and 4 of treatment, and at 4 and 8 weeks post-treatment (Weeks 8 and 12) using Michigan Neuropathy Screening Instrument (MNSI) and Diabetes-Specific Quality of Life (DSQL) scores, nerve conduction velocity (NCV), and blood rheology parameters.</div></div><div><h3>Results</h3><div>Most (58/68) patients completed the trial. MNSI scores were significantly lower at every time point (<em>P</em> < 0.01), and DSQL scores were significantly lower at Weeks 4, 8, and 12 (<em>P</em> < 0.001), compared with baseline in both groups. The LM group had lower MNSI scores at Week 4 (<em>P</em> < 0.05), and lower DSQL scores at Weeks 4, 8, and 12 (<em>P</em> < 0.05) compared with the sham LM group. At Week 4, there was no significant between-group difference in NCV (<em>P</em> > 0.05). Post-treatment, there were no significant differences in blood rheology parameters compared with baseline within each group (<em>P</em> > 0.05). Whole blood high-shear reductive viscosity and red blood cell rigidity index were significantly lower in the LM group than in the sham LM group (<em>P</em> < 0.01). No serious adverse events were recorded.</div></div><div><h3>Conclusion</h3><div>Treatment with 10.6-μm LM improved clinical symptoms and quality of life in patients with DPN.</div></div><div><h3>Clinical Trial Registration</h3><div>Chinese Clinical Trial Registry, ChiCTR2000029329. Registered 25 January 2020, <span><span>https://www.chictr.org.cn/showproj.html?proj=48490</span><svg><path></path></svg></span></div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103259"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-24DOI: 10.1016/j.ctim.2025.103272
Xiaohan Yu , Bohong Liu , Jiaxin Li , Yuanjie Gao , Jianpeng Chen , Rongming Qi , Yuxuan Yuan , Yaru Liu
Objective
This systematic review aimed to evaluate the existing randomized controlled trials (RCTs) for evidence of the association between using acupressure and reducing pain and related symptoms of primary dysmenorrhea (PD).
Methods
Six electronic databases were searched for published reports on RCTs—from database inception until May 2025—that compared the use of acupressure with that of placebo acupressure, oral medication, or usual treatment and measured the intensity of menstrual pain and related symptoms. Two independent reviewers extracted and assessed the data. Risk of bias was assessed for each article; the meta-analysis was conducted according to the type of control. Results are presented as mean differences (MDs) or standardised mean differences (SMDs) and 95 % confidence intervals (CIs).
Results
In total, 23 RCTs were included in the systematic review and data from 20 RCTs were evaluated in the meta-analysis. Most studies showed a low or unclear risk of bias. We found that using acupressure was more effective in reducing menstrual pain than using placebo acupressure (MD = −1.58; 95 % CI, [−1.96, −1.20]), oral medication (MD = −1.11; 95 % CI, [−1.79, −0.43]), or usual treatment (MD = −1.29; 95 % CI, [−1.77, −0.80]). The adverse events, reported in only two studies, were mild.
Conclusion
Acupressure can effectively reduce the pain and related symptoms of PD, though the current evidence is of low quality. Future studies with rigorous designs and larger sample sizes are warranted to verify the efficacy and safety of acupressure. Subsequent findings should be incorporated into clinical practice and nursing care to refine the treatment strategies for PD.
{"title":"Efficacy and safety of acupressure for primary dysmenorrhea: A systematic review and meta-analysis of randomized controlled trials","authors":"Xiaohan Yu , Bohong Liu , Jiaxin Li , Yuanjie Gao , Jianpeng Chen , Rongming Qi , Yuxuan Yuan , Yaru Liu","doi":"10.1016/j.ctim.2025.103272","DOIUrl":"10.1016/j.ctim.2025.103272","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review aimed to evaluate the existing randomized controlled trials (RCTs) for evidence of the association between using acupressure and reducing pain and related symptoms of primary dysmenorrhea (PD).</div></div><div><h3>Methods</h3><div>Six electronic databases were searched for published reports on RCTs—from database inception until May 2025—that compared the use of acupressure with that of placebo acupressure, oral medication, or usual treatment and measured the intensity of menstrual pain and related symptoms. Two independent reviewers extracted and assessed the data. Risk of bias was assessed for each article; the meta-analysis was conducted according to the type of control. Results are presented as mean differences (MDs) or standardised mean differences (SMDs) and 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>In total, 23 RCTs were included in the systematic review and data from 20 RCTs were evaluated in the meta-analysis. Most studies showed a low or unclear risk of bias. We found that using acupressure was more effective in reducing menstrual pain than using placebo acupressure (MD = −1.58; 95 % CI, [−1.96, −1.20]), oral medication (MD = −1.11; 95 % CI, [−1.79, −0.43]), or usual treatment (MD = −1.29; 95 % CI, [−1.77, −0.80]). The adverse events, reported in only two studies, were mild.</div></div><div><h3>Conclusion</h3><div>Acupressure can effectively reduce the pain and related symptoms of PD, though the current evidence is of low quality. Future studies with rigorous designs and larger sample sizes are warranted to verify the efficacy and safety of acupressure. Subsequent findings should be incorporated into clinical practice and nursing care to refine the treatment strategies for PD.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103272"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145360721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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