Pub Date : 2024-11-13DOI: 10.1016/j.ctim.2024.103110
Chen Liu , Shuqing Liu , Yu Wang , Xinyi Xia , Yu Zhang , Huili Jiang , Tuya Bao , Xuehong Ma
Background
Acupuncture, a therapy created by the ancient Chinese, has been gaining increasing popularity and acceptance worldwid. The surge in the number of publications on acupuncture therapy has posed significant challenges for researchers in effectively managing the vast amount of information. This study aimed to analyze the themes and topics of the scientific publications related to acupuncture therapy in the past two decades by machine learning.
Methods
The MeSH term "Acupuncture Therapy" was used for searching publications from 1st January, 2004–31 st December, 2023 on the PubMed database, while the R platform was adopted to obtain associated data. A topic network was constructed by latent Dirichlet allocation (LDA) and the Louvain algorithm.
Results
A total of 17,584 publications were finally recruited in this article. The publications were derived from 57 countries, with China, The United States and England being the top three countries. "Acupuncture Points", "Treatment outcome", "Electroacupuncture" were the most concerned MeSH terms. Four clusters and 50 branched topics were recognized by LDA and network analyses. "Comparative Efficacy", "Biochemical Analysis", "Symptomatic Treatment", "Professional Practice" and "Clinical Trials" are hotspots identified by LDA. "Neurotransmitter", "Meta-Analysis" and "Literature Review" have presented as new research hotspots.
Conclusions
Acupuncture therapy has obtained increasing attention over the past two decades. Most of the studies focus on the mechanisms especially the analgesic and anti-inflammatory mechanisms, more researches such as "Neurotransmitter" will continue to advance. Besides, "meta-analysis" and "literature reviews" are increasingly common, providing more comprehensive and credible evidence for acupuncture therapy.
{"title":"A comprehensive overview of acupuncture therapy over the past 20 years: Machine learning-based bibliometric analysis","authors":"Chen Liu , Shuqing Liu , Yu Wang , Xinyi Xia , Yu Zhang , Huili Jiang , Tuya Bao , Xuehong Ma","doi":"10.1016/j.ctim.2024.103110","DOIUrl":"10.1016/j.ctim.2024.103110","url":null,"abstract":"<div><h3>Background</h3><div>Acupuncture, a therapy created by the ancient Chinese, has been gaining increasing popularity and acceptance worldwid. The surge in the number of publications on acupuncture therapy has posed significant challenges for researchers in effectively managing the vast amount of information. This study aimed to analyze the themes and topics of the scientific publications related to acupuncture therapy in the past two decades by machine learning.</div></div><div><h3>Methods</h3><div>The MeSH term \"Acupuncture Therapy\" was used for searching publications from 1st January, 2004–31 st December, 2023 on the PubMed database, while the R platform was adopted to obtain associated data. A topic network was constructed by latent Dirichlet allocation (LDA) and the Louvain algorithm.</div></div><div><h3>Results</h3><div>A total of 17,584 publications were finally recruited in this article. The publications were derived from 57 countries, with China, The United States and England being the top three countries. \"Acupuncture Points\", \"Treatment outcome\", \"Electroacupuncture\" were the most concerned MeSH terms. Four clusters and 50 branched topics were recognized by LDA and network analyses. \"Comparative Efficacy\", \"Biochemical Analysis\", \"Symptomatic Treatment\", \"Professional Practice\" and \"Clinical Trials\" are hotspots identified by LDA. \"Neurotransmitter\", \"Meta-Analysis\" and \"Literature Review\" have presented as new research hotspots.</div></div><div><h3>Conclusions</h3><div>Acupuncture therapy has obtained increasing attention over the past two decades. Most of the studies focus on the mechanisms especially the analgesic and anti-inflammatory mechanisms, more researches such as \"Neurotransmitter\" will continue to advance. Besides, \"meta-analysis\" and \"literature reviews\" are increasingly common, providing more comprehensive and credible evidence for acupuncture therapy.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"88 ","pages":"Article 103110"},"PeriodicalIF":3.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1016/j.ctim.2024.103111
Mina Wang , Chunying Ma , Anming Liu , Hongli Xiao , Yashuo Ren , Zhuohao Li , Zixi Wang , Qiuyu Xia , Pu Dou , Bin Li , Peng Chen
Background
Parkinson's disease non-motor symptoms (PD-NMS) significantly affect patients' quality of life. Acupuncture has emerged as a potential complementary therapy for PD-NMS. This study aims to investigate general research status, hotspots and trends of acupuncture as a treatment for PD-NMS.
Methods
Literature on Web of Science Core Collection (WoSCC) from 2003 to 2023 was retrieved, and bibliometric analysis was conducted using VOSviewer and CiteSpace software.
Results
159 publications by 894 authors from 37 countries, 300 institutions, and 96 journals were retrieved and analyzed. The number of publications in this field is generally on the rise yearly. China was the leading contributor with 57 publications, and the United States followed with 36 publications and had the highest total citation count of 1562. Guangzhou University of Chinese Medicine ranked the highest with a total of 12 publications, while Harvard University had the highest average citation rate of 70 citations per publication. Evidence-Based Complementary and Alternative Medicine was the most prolific journal with 11 articles that had accumulated 122 citations. Park Hi-Joon was the leading contributor with seven articles and 314 citations. The keyword analysis highlighted emerging areas of interest like “deep brain stimulation” and “alpha-synuclein”.
Conclusion
Different countries, institutions, and authors should enhance cooperations, and the underlying mechanisms of acupuncture for PD-NMS should be demonstrated. This study will be helpful for better understanding the current knowledge and gaps in the areas of acupuncture as a treatment of PD-NMS.
{"title":"A bibliometric analysis of acupuncture for Parkinson’s disease non-motor symptoms from 2003 to 2023","authors":"Mina Wang , Chunying Ma , Anming Liu , Hongli Xiao , Yashuo Ren , Zhuohao Li , Zixi Wang , Qiuyu Xia , Pu Dou , Bin Li , Peng Chen","doi":"10.1016/j.ctim.2024.103111","DOIUrl":"10.1016/j.ctim.2024.103111","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson's disease non-motor symptoms (PD-NMS) significantly affect patients' quality of life. Acupuncture has emerged as a potential complementary therapy for PD-NMS. This study aims to investigate general research status, hotspots and trends of acupuncture as a treatment for PD-NMS.</div></div><div><h3>Methods</h3><div>Literature on Web of Science Core Collection (WoSCC) from 2003 to 2023 was retrieved, and bibliometric analysis was conducted using VOSviewer and CiteSpace software.</div></div><div><h3>Results</h3><div>159 publications by 894 authors from 37 countries, 300 institutions, and 96 journals were retrieved and analyzed. The number of publications in this field is generally on the rise yearly. China was the leading contributor with 57 publications, and the United States followed with 36 publications and had the highest total citation count of 1562. Guangzhou University of Chinese Medicine ranked the highest with a total of 12 publications, while Harvard University had the highest average citation rate of 70 citations per publication. Evidence-Based Complementary and Alternative Medicine was the most prolific journal with 11 articles that had accumulated 122 citations. Park Hi-Joon was the leading contributor with seven articles and 314 citations. The keyword analysis highlighted emerging areas of interest like “deep brain stimulation” and “alpha-synuclein”.</div></div><div><h3>Conclusion</h3><div>Different countries, institutions, and authors should enhance cooperations, and the underlying mechanisms of acupuncture for PD-NMS should be demonstrated. This study will be helpful for better understanding the current knowledge and gaps in the areas of acupuncture as a treatment of PD-NMS.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103111"},"PeriodicalIF":3.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 pandemic overburdened the healthcare system and affected the mental health of healthcare workers. Yoga has proven to improve mental health correlates, within diverse population groups, including healthcare workers. Considering the pandemic-imposed restrictions, this trial was designed to study the feasibility and effect of tele-yoga intervention on burnout, sleep quality, depression, anxiety, stress, mindfulness, and immune markers of healthcare workers on COVID-19 duty.
Methods
This randomized controlled trial was conducted in a tertiary care hospital. Tele-yoga intervention was delivered five days a week for 8 weeks. Stanford Professional Fulfilment Index (SPFI), Pittsburg Sleep Quality Index (PSQI), Depression Anxiety and Stress Scale (DASS-21), Mindfulness Attention Awareness Scale (MAAS) were used to assess the burnout, sleep quality, depression, anxiety, stress and mindfulness. Blood samples were assessed for TNF-α, IL-6 and serum cortisol levels.
Results
A total of 147 healthcare workers were screened to achieve a sample size of 90 (45 each in tele-yoga intervention and control group). Of the 45 subjects in the intervention group, 35 attended at least 50 % of sessions over 8 weeks, at the rate of 3.35 sessions per week. Nearly 37.14 % of subjects among 35 were able to attend more than 70 % of the tele-yoga sessions. At the endline, 35 in the intervention and 37 in the control group completed the outcome questionnaires. On both per protocol (PPA) and intention to treat analyses (ITT) the burnout index, PSQI, anxiety and stress scores and IL-6 and serum cortisol level were significantly lower among the tele-yoga group compared to control group participants (p<0.05) at the endline. The effect size was medium (r=0.3–0.5) favoring intervention group for most of the parameters.
Conclusions
Tele-yoga is a feasible and accessible intervention for improving burnout, sleep quality, and reducing anxiety, stress, IL-6, and serum cortisol among healthcare workers in tertiary care hospitals during the COVID-19 pandemic. Being a single-center pilot study in India and with other methodological limitations, the generalizability of the study findings is restricted.
{"title":"Effect of tele-yoga on burnout, mental health and immune markers of health care workers on COVID-19 duty: An open-label parallel group pilot randomized controlled trial","authors":"K.H. Naveen , Deepeshwar Singh , Srikanth Srinivasan , Pankaj Bhardwaj , Prasenjit Mitra , Kamla Kant Shukla , Sojit Tomo , Krishna Dwivedi , Prem Prakash Sharma , Pritish Baskaran , Ravindra Shukla , Himanshu Vyas , Ashok Kumar , Naresh Midha , Mahendra Kumar Garg , Praveen Sharma , Sanjeev Misra","doi":"10.1016/j.ctim.2024.103109","DOIUrl":"10.1016/j.ctim.2024.103109","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic overburdened the healthcare system and affected the mental health of healthcare workers. Yoga has proven to improve mental health correlates, within diverse population groups, including healthcare workers. Considering the pandemic-imposed restrictions, this trial was designed to study the feasibility and effect of tele-yoga intervention on burnout, sleep quality, depression, anxiety, stress, mindfulness, and immune markers of healthcare workers on COVID-19 duty.</div></div><div><h3>Methods</h3><div>This randomized controlled trial was conducted in a tertiary care hospital. Tele-yoga intervention was delivered five days a week for 8 weeks. Stanford Professional Fulfilment Index (SPFI), Pittsburg Sleep Quality Index (PSQI), Depression Anxiety and Stress Scale (DASS-21), Mindfulness Attention Awareness Scale (MAAS) were used to assess the burnout, sleep quality, depression, anxiety, stress and mindfulness. Blood samples were assessed for TNF-α, IL-6 and serum cortisol levels.</div></div><div><h3>Results</h3><div>A total of 147 healthcare workers were screened to achieve a sample size of 90 (45 each in tele-yoga intervention and control group). Of the 45 subjects in the intervention group, 35 attended at least 50 % of sessions over 8 weeks, at the rate of 3.35 sessions per week. Nearly 37.14 % of subjects among 35 were able to attend more than 70 % of the tele-yoga sessions. At the endline, 35 in the intervention and 37 in the control group completed the outcome questionnaires. On both per protocol (PPA) and intention to treat analyses (ITT) the burnout index, PSQI, anxiety and stress scores and IL-6 and serum cortisol level were significantly lower among the tele-yoga group compared to control group participants (p<0.05) at the endline. The effect size was medium (r=0.3–0.5) favoring intervention group for most of the parameters.</div></div><div><h3>Conclusions</h3><div>Tele-yoga is a feasible and accessible intervention for improving burnout, sleep quality, and reducing anxiety, stress, IL-6, and serum cortisol among healthcare workers in tertiary care hospitals during the COVID-19 pandemic. Being a single-center pilot study in India and with other methodological limitations, the generalizability of the study findings is restricted.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103109"},"PeriodicalIF":3.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.ctim.2024.103101
Krishnagopal Mondal, Swarup Ghosh, Subhasish Chatterjee, Mousumi Saha
{"title":"Letter to Editor on “Self-stretching exercises with kinesio taping for management of chronic nonspecific neck pain in taxi drivers: A single-blind, randomized controlled trial”","authors":"Krishnagopal Mondal, Swarup Ghosh, Subhasish Chatterjee, Mousumi Saha","doi":"10.1016/j.ctim.2024.103101","DOIUrl":"10.1016/j.ctim.2024.103101","url":null,"abstract":"","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103101"},"PeriodicalIF":3.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31DOI: 10.1016/j.ctim.2024.103106
Siliana Maria Duarte Miranda , Sara de Pinho Cunha Paiva , Luiz Fernando Ferreira Pereira , Gabriela Patrus Ananias de Assis Pires , Andrew Nogueira Albuquerque Leal , Giane Amorim Ribeiro-Samora , Eliane Viana Mancuzo
Rationale
Dyspnea and cough are frequent symptoms in ILD patients. The management of these symptoms is challenging, and evidence-based therapies are lacking.
Objectives
To evaluate the effect of an online Mindfulness-Based Intervention (eMBI) on reducing dyspnea in patients affected by different ILDs.
Methods
This study was a prospective, open-label, controlled trial that included patients ≥18 years and a modified Medical Research Council (mMRC) dyspnea scale score of ≥ 1. Patients were randomized into either the eMBI or the control group (CG) for 8 weeks. The primary outcome was the change in the dyspnea mMRC scale. The Leicester Cough Questionnaire (LCQ), King's Brief Interstitial Lung Disease (K-BILD) questionnaire, and Depression, Anxiety, and Stress Scale (DASS-21) were performed before and after the eight weeks. All analyses were conducted on an intention-to-treat basis. The study was registered at the Brazilian Registry of Clinical Trials (ReBEC), RBR-3s4mf9y.
Results
24 patients in the eMBI and 25 in the CG completed the intervention. In the eMBI group, compared to the control group, there was a greater proportion of patients with a reduction in dyspnea according to the mMRC scale score (48.9 % versus, 15.4 %, p = 0.001). There was no significant difference between the groups in the LCQ (p = 0.666), or in the K-BILD (p = 0.108), depression (p = 0.08), or anxiety (p = 0.869 or stress (p = 0.789). No moderate or severe adverse events were observed in either group.
Conclusions
Eight weeks eMBI is a potentially viable and safe approach, that can help manage dyspnea in ILD patients.
{"title":"Online Mindfulness-Based Intervention (eMBI) in management of dyspnea in patients with interstitial lung disease: A randomized clinical trial","authors":"Siliana Maria Duarte Miranda , Sara de Pinho Cunha Paiva , Luiz Fernando Ferreira Pereira , Gabriela Patrus Ananias de Assis Pires , Andrew Nogueira Albuquerque Leal , Giane Amorim Ribeiro-Samora , Eliane Viana Mancuzo","doi":"10.1016/j.ctim.2024.103106","DOIUrl":"10.1016/j.ctim.2024.103106","url":null,"abstract":"<div><h3>Rationale</h3><div>Dyspnea and cough are frequent symptoms in ILD patients. The management of these symptoms is challenging, and evidence-based therapies are lacking.</div></div><div><h3>Objectives</h3><div>To evaluate the effect of an online Mindfulness-Based Intervention (eMBI) on reducing dyspnea in patients affected by different ILDs.</div></div><div><h3>Methods</h3><div>This study was a prospective, open-label, controlled trial that included patients ≥18 years and a modified Medical Research Council (mMRC) dyspnea scale score of ≥ 1. Patients were randomized into either the eMBI or the control group (CG) for 8 weeks. The primary outcome was the change in the dyspnea mMRC scale. The Leicester Cough Questionnaire (LCQ), King's Brief Interstitial Lung Disease (K-BILD) questionnaire, and Depression, Anxiety, and Stress Scale (DASS-21) were performed before and after the eight weeks. All analyses were conducted on an intention-to-treat basis. The study was registered at the Brazilian Registry of Clinical Trials (ReBEC), RBR-3s4mf9y.</div></div><div><h3>Results</h3><div>24 patients in the eMBI and 25 in the CG completed the intervention. In the eMBI group, compared to the control group, there was a greater proportion of patients with a reduction in dyspnea according to the mMRC scale score (48.9 % versus, 15.4 %, p = 0.001). There was no significant difference between the groups in the LCQ (p = 0.666), or in the K-BILD (p = 0.108), depression (p = 0.08), or anxiety (p = 0.869 or stress (p = 0.789). No moderate or severe adverse events were observed in either group.</div></div><div><h3>Conclusions</h3><div>Eight weeks eMBI is a potentially viable and safe approach, that can help manage dyspnea in ILD patients.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103106"},"PeriodicalIF":3.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Long COVID have posed a global health burden since the COVID-19 pandemic. This study aimed to evaluate the efficacy and safety of a combined plant extract (CPE) formulation, containing Citrus aurantifolia, Tiliacora triandra, Cannabis sativa, Alpinia galanga, and Piper nigrum, in participants with long COVID. A newly developed long COVID symptom questionnaire was used to evaluate outcomes.
Methods
This randomized, double-blinded, placebo-controlled trial was conducted at the College of Pharmacy, Rangsit University, Thailand. Participants were randomly assigned to receive either a CPE supplement (4500 mg/day) or a placebo for 7 days. Primary outcomes were changes in C-reactive protein (CRP) levels and the total symptom score (ranging from 0 to 57 points). Secondary outcomes included full recovery/improvement of long COVID symptoms, health-related quality of life (HRQOL), and adverse events.
Results
A total of 66 participants were enrolled, with 33 in each group. The CPE supplement did not significantly reduce CRP levels, with a median difference (MD) (95 % CI) of −0.05 (−0.49, 0.39) mg/L compared to placebo. However, the CPE group showed a reduction in the total symptom score [MD (95 % CI) of −4.00 (−7.58, −0.42)], and a reduction in overall moderate to severe symptoms [RR (95 % CI) of 0.57 (0.35, 0.91)], moderate to severe fatigue [RR (95 % CI) of 0.25 (0.08, 0.81)], and moderate to severe post-exertional malaise (PEM) [RR (95 % CI) of 0.35 (0.16, 0.78)]. Changes in HRQOL scores did not differ significantly between groups. Adverse events were mostly mild and resolved by the end of the follow-up period.
Conclusions
Our study suggests potential benefits of the CPE in alleviating moderate to severe long COVID symptoms, particularly fatigue and PEM, with an acceptable safety profile. However, larger-scale trials are necessary to validate these findings, and assessing the reliability of the long COVID symptom questionnaire is essential before its application in future studies.
{"title":"Impact of combined plant extracts on long COVID: An exploratory randomized controlled trial","authors":"Thitiya Lukkunaprasit , Patompong Satapornpong , Pongsiri Kulchanawichien , Abhisit Prawang , Chaiwat Limprasert , Worawan Saingam , Chatpetch Permsombut , Wongvarit Panidthananon , Arthimond Vutthipong , Yupin Lawanprasert , Parnthep Pourpongpan , Supakit Wongwiwatthananukit , Thanapat Songsak , Nalinee Pradubyat","doi":"10.1016/j.ctim.2024.103107","DOIUrl":"10.1016/j.ctim.2024.103107","url":null,"abstract":"<div><h3>Background</h3><div>Long COVID have posed a global health burden since the COVID-19 pandemic. This study aimed to evaluate the efficacy and safety of a combined plant extract (CPE) formulation, containing <em>Citrus aurantifolia</em>, <em>Tiliacora triandra</em>, <em>Cannabis sativa</em>, <em>Alpinia galanga</em>, and <em>Piper nigrum</em>, in participants with long COVID. A newly developed long COVID symptom questionnaire was used to evaluate outcomes.</div></div><div><h3>Methods</h3><div>This randomized, double-blinded, placebo-controlled trial was conducted at the College of Pharmacy, Rangsit University, Thailand. Participants were randomly assigned to receive either a CPE supplement (4500 mg/day) or a placebo for 7 days. Primary outcomes were changes in C-reactive protein (CRP) levels and the total symptom score (ranging from 0 to 57 points). Secondary outcomes included full recovery/improvement of long COVID symptoms, health-related quality of life (HRQOL), and adverse events.</div></div><div><h3>Results</h3><div>A total of 66 participants were enrolled, with 33 in each group. The CPE supplement did not significantly reduce CRP levels, with a median difference (MD) (95 % CI) of −0.05 (−0.49, 0.39) mg/L compared to placebo. However, the CPE group showed a reduction in the total symptom score [MD (95 % CI) of −4.00 (−7.58, −0.42)], and a reduction in overall moderate to severe symptoms [RR (95 % CI) of 0.57 (0.35, 0.91)], moderate to severe fatigue [RR (95 % CI) of 0.25 (0.08, 0.81)], and moderate to severe post-exertional malaise (PEM) [RR (95 % CI) of 0.35 (0.16, 0.78)]. Changes in HRQOL scores did not differ significantly between groups. Adverse events were mostly mild and resolved by the end of the follow-up period.</div></div><div><h3>Conclusions</h3><div>Our study suggests potential benefits of the CPE in alleviating moderate to severe long COVID symptoms, particularly fatigue and PEM, with an acceptable safety profile. However, larger-scale trials are necessary to validate these findings, and assessing the reliability of the long COVID symptom questionnaire is essential before its application in future studies.</div></div><div><h3>Trial registration number:</h3><div>TCTR20230131004 (Registration date: 2023–01–31, Thai Clinical Trials Registry).</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103107"},"PeriodicalIF":3.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-28DOI: 10.1016/j.ctim.2024.103102
Xiaochen Li , Xue Yang , Jibing Ou , Yao Zhou , Lei Xi , Yuzhe Zou , Zihan Chen , Dingwei He , Liqing Yao , Weimo Zhu
Background
The scope of hot spring research is continuously growing, with the application of hot spring medicine emerging as a significant trend. However, there is a lack of bibliometric analyses that summarize the current state and trends of the application of hot spring medicine.
Objectives
Using bibliometric analysis, this study aims to visualize and analyze the global landscape and emerging trends in hot spring research, focusing on the hotspots and future directions of hot spring medicine application.
Methods
Literature from 1994 to 2023 was compiled from the Web of Science Core Collection (WoSCC) database, visualized using Citespace and VOSviewer, analyzing publication trends, keyword co-occurrence, key institutions, and research directions in global hot spring studies. Similarly, literature on the application of hot spring medicine from 2000 to 2024 was also collected.
Results
A total of 8020 studies on the global field of hot springs and 68 studies on the application of hot spring medicine met the inclusion criteria. Linear regression reveals significant yearly increases in publication volume (p < 0.001). Five primary research trends including applications, components, diseases, mechanisms, and regions have been identified. Japan and France emerge as the primary contributor to the medical applications of hot springs.
Conclusion
Examining utilization patterns, conducting compositional tests, investigating therapeutic mechanisms, and scrutinizing geographical disparities aid in enhancing the comprehension of hot springs for medical applications. This validates the application of hot spring medicine as a frontier trend and new hotspot in hot spring research.
{"title":"Overview and trend analysis of global hot spring research based on bibliometrics and knowledge graph visualization","authors":"Xiaochen Li , Xue Yang , Jibing Ou , Yao Zhou , Lei Xi , Yuzhe Zou , Zihan Chen , Dingwei He , Liqing Yao , Weimo Zhu","doi":"10.1016/j.ctim.2024.103102","DOIUrl":"10.1016/j.ctim.2024.103102","url":null,"abstract":"<div><h3>Background</h3><div>The scope of hot spring research is continuously growing, with the application of hot spring medicine emerging as a significant trend. However, there is a lack of bibliometric analyses that summarize the current state and trends of the application of hot spring medicine.</div></div><div><h3>Objectives</h3><div>Using bibliometric analysis, this study aims to visualize and analyze the global landscape and emerging trends in hot spring research, focusing on the hotspots and future directions of hot spring medicine application.</div></div><div><h3>Methods</h3><div>Literature from 1994 to 2023 was compiled from the Web of Science Core Collection (WoSCC) database, visualized using Citespace and VOSviewer, analyzing publication trends, keyword co-occurrence, key institutions, and research directions in global hot spring studies. Similarly, literature on the application of hot spring medicine from 2000 to 2024 was also collected.</div></div><div><h3>Results</h3><div>A total of 8020 studies on the global field of hot springs and 68 studies on the application of hot spring medicine met the inclusion criteria. Linear regression reveals significant yearly increases in publication volume (<em>p</em> < 0.001). Five primary research trends including applications, components, diseases, mechanisms, and regions have been identified. Japan and France emerge as the primary contributor to the medical applications of hot springs.</div></div><div><h3>Conclusion</h3><div>Examining utilization patterns, conducting compositional tests, investigating therapeutic mechanisms, and scrutinizing geographical disparities aid in enhancing the comprehension of hot springs for medical applications. This validates the application of hot spring medicine as a frontier trend and new hotspot in hot spring research.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103102"},"PeriodicalIF":3.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-28DOI: 10.1016/j.ctim.2024.103105
Ruixuan Liu , Lei Liang , Hai Huang , Zhongyi Zeng , Jian Sun
Introduction
Mechanical ventilation after respiratory insufficiency can induce diaphragm dysfunction through various hypothesized mechanisms. In this study, we evaluated the rehabilitative effect of acupuncture on diaphragm function in patients with respiratory insufficiency using meta-analysis and summarised the rules of acupoints through association rules analysis.
Methods
Articles (published from January 2000 to February 2024) were retrieved from the following databases: PubMed, Cochrane Library, Embase, Web of Science, CNKI, VIP, SinoMed, and Wanfang. Two researchers conducted literature selection, data extraction, and statistical analysis independently. The risk of bias was assessed utilizing the Physical Therapy Evidence Database (PEDro) scale. The meta-analysis was performed with RevMan 5.4 software, and the quality of each outcome evidence was assessed via the online software GRADEpro GDT. The regularity of acupoint selection was summarized using association rules analysis. This study is registered on PROSPERO, number CRD42024526705.
Results
Eleven articles were eventually included, all of which were of low to moderate quality. Results of the meta-analysis showed a significant increase in diaphragmatic thickening fraction (MD 3.40 [1.52, 5.27]) and diaphragmatic excursion (MD 0.95 [0.58, 1.31]) in patients with respiratory insufficiency after acupuncture treatment. Also, OI (MD 28.52 [15.93, 41.11]) and PaO2 (MD 7.18 [2.22, 12.13]) were significantly elevated and PaCO2 (MD −6.94 [-12.30, −1.59]) was decreased. Mechanical ventilation time (MD-1.86 [-2.28, −1.45]) was also significantly improved. The overall quality of the outcome evidence is deemed moderate. Association rules analysis showed that ST36, RN4, RN6, and others are core acupoints for the treatment of diaphragmatic dysfunction in patients with respiratory insufficiency by acupuncture.
Conclusion
Acupuncture shows potential in the rehabilitation of patients with respiratory insufficiency and may serve as a complementary and alternative therapy for related conditions. We suggest the use of ST36 as a core acupoint, in combination with other acupoints. Due to the potential publication bias and high heterogeneity of the current data, further high-quality RCTs are needed to confirm these findings.
{"title":"Rehabilitation effects of acupuncture on the diaphragmatic dysfunction in respiratory insufficiency: A systematic review and meta-analysis","authors":"Ruixuan Liu , Lei Liang , Hai Huang , Zhongyi Zeng , Jian Sun","doi":"10.1016/j.ctim.2024.103105","DOIUrl":"10.1016/j.ctim.2024.103105","url":null,"abstract":"<div><h3>Introduction</h3><div>Mechanical ventilation after respiratory insufficiency can induce diaphragm dysfunction through various hypothesized mechanisms. In this study, we evaluated the rehabilitative effect of acupuncture on diaphragm function in patients with respiratory insufficiency using meta-analysis and summarised the rules of acupoints through association rules analysis.</div></div><div><h3>Methods</h3><div>Articles (published from January 2000 to February 2024) were retrieved from the following databases: PubMed, Cochrane Library, Embase, Web of Science, CNKI, VIP, SinoMed, and Wanfang. Two researchers conducted literature selection, data extraction, and statistical analysis independently. The risk of bias was assessed utilizing the Physical Therapy Evidence Database (PEDro) scale. The meta-analysis was performed with RevMan 5.4 software, and the quality of each outcome evidence was assessed via the online software GRADEpro GDT. The regularity of acupoint selection was summarized using association rules analysis. This study is registered on PROSPERO, number CRD42024526705.</div></div><div><h3>Results</h3><div>Eleven articles were eventually included, all of which were of low to moderate quality. Results of the meta-analysis showed a significant increase in diaphragmatic thickening fraction (MD 3.40 [1.52, 5.27]) and diaphragmatic excursion (MD 0.95 [0.58, 1.31]) in patients with respiratory insufficiency after acupuncture treatment. Also, OI (MD 28.52 [15.93, 41.11]) and PaO<sub>2</sub> (MD 7.18 [2.22, 12.13]) were significantly elevated and PaCO<sub>2</sub> (MD −6.94 [-12.30, −1.59]) was decreased. Mechanical ventilation time (MD-1.86 [-2.28, −1.45]) was also significantly improved. The overall quality of the outcome evidence is deemed moderate. Association rules analysis showed that ST36, RN4, RN6, and others are core acupoints for the treatment of diaphragmatic dysfunction in patients with respiratory insufficiency by acupuncture.</div></div><div><h3>Conclusion</h3><div>Acupuncture shows potential in the rehabilitation of patients with respiratory insufficiency and may serve as a complementary and alternative therapy for related conditions. We suggest the use of ST36 as a core acupoint, in combination with other acupoints. Due to the potential publication bias and high heterogeneity of the current data, further high-quality RCTs are needed to confirm these findings.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103105"},"PeriodicalIF":3.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-23DOI: 10.1016/j.ctim.2024.103103
Ling-Hui Ma , Jing-Yun Xiu , Liang-Xiao Ma , Qin-Yong Zhang , Xiu-Yan Wang , Tian-Yi Sun , Xu Qian , Meng-Yu Chen , Jia-Ling He
Background
Transcutaneous electrical acupoint stimulation (TEAS) may contribute to blood pressure (BP) control, but the evidence remains insufficient. Our objectives were to evaluate the impact of TEAS on hypertension and determine the optimal frequency.
Methods
A total of 120 hypertensive patients were randomly allocated to the TEAS-2Hz group, TEAS-10Hz group, or usual care control group in a 1:1:1 ratio. All patients were advised to continue their usual antihypertensive regimen. Additionally, patients in the TEAS groups received TEAS therapy 3 times per week for 4 weeks, with a 4-week follow-up.
Results
The primary outcome was the change in systolic BP (SBP) from baseline to week 4. Secondary outcomes included changes in diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), heart rate variability (HRV), and 12-item health survey (SF-12) at different time points. Both TEAS groups showed reductions in SBP relative to control (TEAS-2Hz group vs. control, −4.70 mmHg [95 % CI, −7.00 to −2.40 mmHg]; P < 0.001; TEAS-10Hz group vs. control, −8.66 mmHg [95 % CI, −10.97 to −6.36 mmHg]; P < 0.001). TEAS-10Hz provided a significant decrease in SBP than TEAS-2Hz (-3.96 mmHg [95 % CI, −1.66 to −6.26 mmHg]; P< 0.001). TEAS groups also exhibited reductions in DBP, MAP, HR, LF/HF ratio（LF/HF）, very low frequency (VLF), and normalized low frequency (LF norm), and an increase in normalized high frequency (HF norm) than control. No differences were observed among groups in low frequency (LF), high frequency (HF), total power (TP), very low frequency (VLF), and SF-12.
Conclusion
TEAS might be a promising adjunctive therapy for hypertension, and the recommended frequency is 10 Hz, which should be confirmed in larger trials.
{"title":"Effect of transcutaneous electrical acupoint stimulation at different frequencies on mild hypertension: A randomized controlled trial","authors":"Ling-Hui Ma , Jing-Yun Xiu , Liang-Xiao Ma , Qin-Yong Zhang , Xiu-Yan Wang , Tian-Yi Sun , Xu Qian , Meng-Yu Chen , Jia-Ling He","doi":"10.1016/j.ctim.2024.103103","DOIUrl":"10.1016/j.ctim.2024.103103","url":null,"abstract":"<div><h3>Background</h3><div>Transcutaneous electrical acupoint stimulation (TEAS) may contribute to blood pressure (BP) control, but the evidence remains insufficient. Our objectives were to evaluate the impact of TEAS on hypertension and determine the optimal frequency.</div></div><div><h3>Methods</h3><div>A total of 120 hypertensive patients were randomly allocated to the TEAS-2Hz group, TEAS-10Hz group, or usual care control group in a 1:1:1 ratio. All patients were advised to continue their usual antihypertensive regimen. Additionally, patients in the TEAS groups received TEAS therapy 3 times per week for 4 weeks, with a 4-week follow-up.</div></div><div><h3>Results</h3><div>The primary outcome was the change in systolic BP (SBP) from baseline to week 4. Secondary outcomes included changes in diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), heart rate variability (HRV), and 12-item health survey (SF-12) at different time points. Both TEAS groups showed reductions in SBP relative to control (TEAS-2Hz group vs. control, −4.70 mmHg [95 % CI, −7.00 to −2.40 mmHg]; P < 0.001; TEAS-10Hz group vs. control, −8.66 mmHg [95 % CI, −10.97 to −6.36 mmHg]; P < 0.001). TEAS-10Hz provided a significant decrease in SBP than TEAS-2Hz (-3.96 mmHg [95 % CI, −1.66 to −6.26 mmHg]; P< 0.001). TEAS groups also exhibited reductions in DBP, MAP, HR, LF/HF ratio（LF/HF）, very low frequency (VLF), and normalized low frequency (LF norm), and an increase in normalized high frequency (HF norm) than control. No differences were observed among groups in low frequency (LF), high frequency (HF), total power (TP), very low frequency (VLF), and SF-12.</div></div><div><h3>Conclusion</h3><div>TEAS might be a promising adjunctive therapy for hypertension, and the recommended frequency is 10 Hz, which should be confirmed in larger trials.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103103"},"PeriodicalIF":3.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div><h3>Background</h3><div>The current practice guideline regarding treatment for insomnia and sleep disturbances among children and adolescents with autism spectrum disorder (ASD) has been published and it suggests that the use of weighted blankets might not be an evidence-informed practice. However, limited guidance and evidence synthesis exist on the overall effectiveness of a weighted blanket for symptom management among patients with mental disorders, although it has been routinely recommended and prescribed for this population in many mental health care settings.</div></div><div><h3>Objective</h3><div>To systematically evaluate and synthesize existing data on the safety and effectiveness of weighted blankets for symptom management among patients with mental disorders.</div></div><div><h3>Methods</h3><div>Comprehensive retrieval of published, unpublished, or ongoing studies was carried out across a series of bibliographic databases, grey literature sources, and clinical trial registry platforms, along with manual screening of the reference lists of the included studies or relevant reviews. Randomized controlled trials (RCTs) were included if they compared a weighted blanket intervention and a control condition among patients with mental disorders. Two reviewers independently extracted the data using a pre-specified form and assessed the methodological quality of the included studies with the revised Cochrane ‘Risk of Bias’ (RoB 2) tool. Review Manager (RevMan) 5.3 software was used to conduct the meta-analysis when possible. Subgroup and sensitivity analyses, where appropriate, were conducted to explore the robustness of the pooled effect estimates.</div></div><div><h3>Results</h3><div>Eight studies involving a total of 426 patients were included in this review. Half of the included studies were rated as having a high risk of bias, primarily due to the failure to blind participants for participant-reported measures. No serious adverse events were reported with the application of weighted blankets. The meta-analysis of five studies revealed that the use of weighted blankets induced a small magnitude decrease (standardized mean difference within studies [SMD]= 0.40) in anxiety management. The pooled estimate of three studies reporting the effect of weighted blankets on insomnia revealed a nonsignificant difference between the two groups (mean difference [MD] = −1.92, 95 % confidence interval [CI] = −3.92–0.09, p = 0.06). However, the leave-one-out sensitivity analysis of the two remaining homogeneous studies revealed that patients who used weighted blankets had reduced insomnia severity index (ISI) scores (MD = −2.78, 95 % CI = −4.44 to −1.12, p = 0.001). Additionally, a study without available data for inclusion in the meta-analysis also reported a positive effect in reducing the ISI score. Due to the heterogeneity across studies, summary estimates for the effects of weighted blankets on fatigue and depression were not computed. However, pr
{"title":"Safety and effectiveness of weighted blankets for symptom management in patients with mental disorders: A systematic review and meta-analysis of randomized controlled trials","authors":"Yanli Zhao , Qiushi Zhang , Zhihua Liu , Zhongjian Zhao , Qinghua Zhu","doi":"10.1016/j.ctim.2024.103104","DOIUrl":"10.1016/j.ctim.2024.103104","url":null,"abstract":"<div><h3>Background</h3><div>The current practice guideline regarding treatment for insomnia and sleep disturbances among children and adolescents with autism spectrum disorder (ASD) has been published and it suggests that the use of weighted blankets might not be an evidence-informed practice. However, limited guidance and evidence synthesis exist on the overall effectiveness of a weighted blanket for symptom management among patients with mental disorders, although it has been routinely recommended and prescribed for this population in many mental health care settings.</div></div><div><h3>Objective</h3><div>To systematically evaluate and synthesize existing data on the safety and effectiveness of weighted blankets for symptom management among patients with mental disorders.</div></div><div><h3>Methods</h3><div>Comprehensive retrieval of published, unpublished, or ongoing studies was carried out across a series of bibliographic databases, grey literature sources, and clinical trial registry platforms, along with manual screening of the reference lists of the included studies or relevant reviews. Randomized controlled trials (RCTs) were included if they compared a weighted blanket intervention and a control condition among patients with mental disorders. Two reviewers independently extracted the data using a pre-specified form and assessed the methodological quality of the included studies with the revised Cochrane ‘Risk of Bias’ (RoB 2) tool. Review Manager (RevMan) 5.3 software was used to conduct the meta-analysis when possible. Subgroup and sensitivity analyses, where appropriate, were conducted to explore the robustness of the pooled effect estimates.</div></div><div><h3>Results</h3><div>Eight studies involving a total of 426 patients were included in this review. Half of the included studies were rated as having a high risk of bias, primarily due to the failure to blind participants for participant-reported measures. No serious adverse events were reported with the application of weighted blankets. The meta-analysis of five studies revealed that the use of weighted blankets induced a small magnitude decrease (standardized mean difference within studies [SMD]= 0.40) in anxiety management. The pooled estimate of three studies reporting the effect of weighted blankets on insomnia revealed a nonsignificant difference between the two groups (mean difference [MD] = −1.92, 95 % confidence interval [CI] = −3.92–0.09, p = 0.06). However, the leave-one-out sensitivity analysis of the two remaining homogeneous studies revealed that patients who used weighted blankets had reduced insomnia severity index (ISI) scores (MD = −2.78, 95 % CI = −4.44 to −1.12, p = 0.001). Additionally, a study without available data for inclusion in the meta-analysis also reported a positive effect in reducing the ISI score. Due to the heterogeneity across studies, summary estimates for the effects of weighted blankets on fatigue and depression were not computed. However, pr","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103104"},"PeriodicalIF":3.3,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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