Complementary therapies in medicine最新文献

{"title":"Effects of seated Baduanjin training modalities on body composition, muscle strength, and gait parameters in older adults: A cluster-randomised controlled trial","authors":"Chia-Feng Chen ,&nbsp;Shu-Ching Chiu ,&nbsp;Ching- Kuei Chiang ,&nbsp;Yu-Wen Lu","doi":"10.1016/j.ctim.2025.103300","DOIUrl":"10.1016/j.ctim.2025.103300","url":null,"abstract":"<div><h3>Background and Objective</h3><div>The relationship between seated exercise frequency and physiological changes in older adults has received insufficient research attention. We examined how Baduanjin session frequency, Baduanjin instructional format, and low-intensity resistance training affect the body composition, muscle strength, and gait parameters of older adults.</div></div><div><h3>Methods</h3><div>A prospective, cluster-randomised, controlled, two-arm trial was conducted at day care centres for older adults in Taiwan over 12 weeks between May and September 2024. The experimental group received a multicomponent seated Baduanjin intervention which included online and in-person sessions and additional resistance training, whereas the control group completed only the online Baduanjin sessions. Body composition was assessed using bioelectrical impedance analysis. Muscle strength of the upper and lower extremities was measured using handheld dynamometers. Gait parameters were evaluated using GaitUp wearable motion sensors.</div></div><div><h3>Results</h3><div>Linear mixed-effects analysis revealed significant between-group differences in grip strength, gait speed, cadence, and load ratio after 12 weeks (<em>p</em> &lt; 0.05). The experimental group maintained their functional abilities, whereas the control group experienced marked declines. No significant changes were observed in skeletal muscle index, body fat percentage, or isometric knee extensor force over the intervention period. Additionally, the foot-flat ratio significantly decreased in the experimental group (<em>p</em> = 0.004) but increased in the control group (<em>p</em> = 0.011); the between-group difference was significant (B = 5.28, 95 % confidence interval [2.14, 8.41], <em>p</em> = 0.001).</div></div><div><h3>Conclusion</h3><div>The multicomponent seated Baduanjin intervention was more effective than the once-weekly Baduanjin sessions in improving physical outcomes. Thus, Baduanjin is a safe, feasible, and beneficial. intervention for older adults. This study was registered on ClinicalTrials.gov (Registration No. NCT06550661) on 6 August 2024.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103300"},"PeriodicalIF":3.5,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the effects of connective tissue massage vs. myofascial release on fibromyalgia pain? Systematic review with meta-analysis","authors":"Francisco C. Ide ,&nbsp;Anderson D’Oliveira ,&nbsp;Ericles de P. Vieira ,&nbsp;Tamiris B. Martins ,&nbsp;Alexandro Andrade ,&nbsp;Iramar B. do Nascimento","doi":"10.1016/j.ctim.2025.103305","DOIUrl":"10.1016/j.ctim.2025.103305","url":null,"abstract":"<div><h3>Objective</h3><div>to verify the impact of the use of connective tissue massage (CTM) technique <em>versus</em> myofascial release (MFR) performed manually by the therapist and foam roller self-myofascial release (FRSMR) performed by the patient on fibromyalgia pain-related outcomes.</div></div><div><h3>Method</h3><div>this is a systematic review and meta-analysis, performed in <em>the</em> PubMed, Web of Science, Scopus, SciELO, LILACS, and Embase databases. The PRISMA 2020 guidelines were followed, and the risk of bias was assessed using the National Institutes of Health tool, with agreement measured by Cohen’s Kappa. Results: 10 studies were included in the qualitative synthesis and meta-analysis. Dysfunctions of the muscle fascia contribute to the pathogenesis of fibromyalgia and can directly influence pain and central sensitization. In the meta-analysis, under the random-effects model, MFR significantly reduced pain (SMD = –1.16, p = 0.0003), whereas CTM did not reach significance (p = 0.29). By contrast, the fixed-effect model underestimated the results due to heterogeneity.</div></div><div><h3>Conclusion</h3><div>MFR has is more effective prognosis in pain reduction compared to CTM. However, the efficacy of MFR depends on the demographic and adaptive factors of the individuals and, especially, on the methodological definition of the intensity and time for which the MFR technique should be applied. In populations of different age groups, FRSMR techniques are recommended to be adapted. The personalized and specific approach of MFR suggests that it could be a promising strategy in the management of fibromyalgia, with the possibility of more robust and sustainable outcomes.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"96 ","pages":"Article 103305"},"PeriodicalIF":3.5,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can transcutaneous electrical acupoint stimulation prevent postoperative nausea and vomiting?","authors":"Yingying Liu ,&nbsp;Zhen Chen ,&nbsp;Zhiqiang Zhang ,&nbsp;Qian Hu ,&nbsp;Jiasheng Wang ,&nbsp;Ruiyang Cao ,&nbsp;Wenkai Liu ,&nbsp;Lifeng Wang","doi":"10.1016/j.ctim.2025.103294","DOIUrl":"10.1016/j.ctim.2025.103294","url":null,"abstract":"<div><div>Postoperative nausea and vomiting (PONV) is a common perioperative complication that can increase the incidence of complications such as aspiration, bleeding, incision dehiscence water-electrolyte disorders; prolong hospital stays; and increase medical costs. Transcutaneous electrical acupoint stimulation (TEAS) is important for preventing perioperative PONV, and TEAS may reduce the incidence of PONV by activating the brain-gut axis and regulating autonomic nerve function, anti-inflammatory activity and other mechanisms; however, it is necessary to further promote standardized clinical application through mechanistic research, parameter optimization and high-quality clinical research.‌ This article discusses the risk factors for PONV, the possible mechanism of TEAS in the prevention of PONV and the clinical application of TEAS to provide some reference for the clinical application of TEAS in preventing PONV.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103294"},"PeriodicalIF":3.5,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145457642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of aromatherapy on physiological and psychological symptoms during pregnancy: a systematic review and meta-analysis","authors":"Victor Hugo Alves Mascarenhas ,&nbsp;Adriana Caroci-Becker ,&nbsp;Jan M. Nick ,&nbsp;Safiye Sahin ,&nbsp;Rayane Teresa da Costa Drigo ,&nbsp;Maria Luiza Riesco ,&nbsp;Marlise de Oliveira Pimentel Lima","doi":"10.1016/j.ctim.2025.103279","DOIUrl":"10.1016/j.ctim.2025.103279","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate the effectiveness of aromatherapy in reducing physiological and psychological symptoms during pregnancy.</div></div><div><h3>Methods</h3><div>This review followed the JBI methodological guidelines for Systematic Reviews of Effectiveness and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Guided by the PICO framework: population (P) comprised pregnant women; intervention (I) was aromatherapy; comparison (C) included conventional treatment, other complementary therapies, or placebo; outcomes (O) involved physiological and psychological symptoms. Experimental and quasi-experimental studies involving pregnant women who received aromatherapy to manage these symptoms were included. Nine databases were searched in January 2022 and August 2024, including Medline, CINAHL, SCOPUS, and Web of Science, yielding 1063 registers.</div></div><div><h3>Results</h3><div>Twenty-one studies were included (16 randomised controlled trials and five quasi-experimental), conducted in Iran, Indonesia, Japan, and Taiwan. Meta-analysis revealed that aromatherapy significantly reduced nausea and vomiting (standardised mean difference [SMD] = −0.92; 95 % confidence interval [CI]: −1.09, −0.74) and maternal anxiety (SMD = −0.67; 95 % CI: −0.95, −0.40). Improvements in sleep quality were also noted (mean difference = −1.55; 95 % CI: −2.09, −1.01).</div></div><div><h3>Conclusion</h3><div>Aromatherapy appears to be an effective and safe option for alleviating certain gestational symptoms. Citrus essential oils such as peppermint, bitter orange, lemon, and mint have been shown to reduce nausea and vomiting. Citrus aurantium, Rosa damascene, mint, and orange blossom have demonstrated efficacy in reducing maternal anxiety. Citrus aurantium, orange blossom, and lavender may also improve sleep quality. However, further high-quality studies with larger sample sizes are warranted.</div></div><div><h3>Registration</h3><div>This systematic review was registered in PROSPERO.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103279"},"PeriodicalIF":3.5,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145450602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of yoga-based mind-body interventions in the management of inflammatory bowel disease","authors":"Linjia Pan ,&nbsp;Xiaotong Chen ,&nbsp;Yiqi Wu ,&nbsp;Zhanyi Zhou ,&nbsp;Daogun Xu","doi":"10.1016/j.ctim.2025.103287","DOIUrl":"10.1016/j.ctim.2025.103287","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory bowel disease (IBD) affects millions worldwide and imposes both physical and psychological burdens. While current treatments have limitations, yoga-based mind-body interventions (YMBIs) show promise in improving symptoms and quality of life through physiological and stress-regulating pathways.</div></div><div><h3>Objective</h3><div>This Meta-analysis seeks to comprehensively and objectively assess the efficacy of yoga-based mind-body interventions on psychological, physical, and inflammatory outcomes in patients with IBD.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in both international and Chinese databases including PubMed, EMBASE, Cochrane Library, Web of Science, Medline, China National Knowledge Infrastructure (CNKI), WanFang, and China Biomedical Literature Service System. Randomized controlled trials (RCTs) comparing YMBIs with standard care or placebo in IBD patients were pooled from inception to February 17, 2025. Data were analyzed using RevMan 5.4 and Stata 16.0, with standardized mean differences (SMDs) and 95 % confidence intervals (CIs) as effect measures.</div></div><div><h3>Results</h3><div>Seven RCTs comprising 502 participants were included. The meta-analysis revealed that YMBIs significantly reduced anxiety (SMD = −0.56, 95 % CI [−0.77 to −0.36], P &lt; 0.0001), depression (SMD = −3.45, 95 % CI [−5.52 to −1.37], P &lt; 0.0001), and perceived stress (SMD = −0.70, 95 % CI [−1.00 to −0.39], P &lt; 0.0001), while improving quality of life (SMD = 0.47, 95 % CI [0.17–0.77], P = 0.002). Effects on sleep quality (SMD = −1.98, 95 % CI [−3.98–0.02], P = 0.05) and disease activity (SMD = −0.26, 95 % CI [−0.52–0.01], P = 0.05) were modest, with borderline statistical significance.</div></div><div><h3>Conclusion</h3><div>YMBIs alleviates psychological distress and enhance well-being in IBD patients, though their impact on disease progression remains uncertain. However, their effects on sleep quality and disease activity require further validation through high-quality clinical studies.</div></div><div><h3>Systematic review registration</h3><div><span><span>https://www.crd.york.ac.uk/PROSPERO/view/CRD420250653339</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103287"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between the treatment frequency and efficacy of acupuncture: A scoping review of clinical trials","authors":"Guodong Li ,&nbsp;Xinyu Hu ,&nbsp;Jingli Xing ,&nbsp;Yiying Wang ,&nbsp;Chenlu Wang ,&nbsp;Wennan Yu ,&nbsp;Jie Lian ,&nbsp;Huijuan Cao","doi":"10.1016/j.ctim.2025.103304","DOIUrl":"10.1016/j.ctim.2025.103304","url":null,"abstract":"<div><h3>Objective</h3><div>To consolidate and analyze the existing evidence on the relationship between acupuncture treatment frequency and its clinical efficacy, clarify research status, trends, and core issues, and provide evidence-based insights for optimizing acupuncture treatment protocols.</div></div><div><h3>Methods</h3><div>Following the Arksey and O’Malley scoping review framework and PRISMA-ScR guidelines, nine databases were searched from inception to February 15, 2025. Associations among frequency, disease, and effectiveness were visualized using heat maps and bubble charts. Between-group differences (high-frequency: more than 3 sessions/week; low-frequency: no more than 3 sessions/week) and their influencing factors were summarized.</div></div><div><h3>Results</h3><div>Ninety-four studies were included. There was a significant disease-specific, nonlinear relationship between acupuncture frequency and efficacy. High-frequency acupuncture (&gt; 3 sessions/week) demonstrated marked advantages in treating degenerative spinal/joint diseases, particularly during acute phases or for short-term symptom relief especially. In contrast, peripheral neuropathies showed lower sensitivity to frequency variations. Efficacy enhancement did not depend solely on increased frequency, however. Instead, we found a \"J-shaped curve\" and plateau effects. Significant interactions existed between frequency and other acupuncture parameters, with their importance varying by disease and treatment goals. The current literature evidence shows significant heterogeneity in its various definitions of treatment frequency, though there is an obvious a paucity of low-frequency studies.</div></div><div><h3>Conclusion</h3><div>Optimizing acupuncture frequency requires dynamic adjustments based on disease type, pathological stage, primary treatment goals, and synergistic effects with other treatment parameters. Current evidence remains limited by methodological quality and parameter interaction complexity, precluding the definition of a universally \"optimal frequency.\" Future research should prioritize sequential factorial trials, standardized frequency criteria, and enhanced health-economic evaluations to advance the precision of acupuncture therapy.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103304"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of traditional Chinese exercises in cardiac rehabilitation of patients after percutaneous coronary intervention: A systematic review and meta-analysis","authors":"Wang Jiale ,&nbsp;Liu Longcheng ,&nbsp;Yuan Haisheng ,&nbsp;Yu Qiushuang ,&nbsp;Ji Xiaodi ,&nbsp;Wang Anqi ,&nbsp;Zhang Ying ,&nbsp;Ma Lihong","doi":"10.1016/j.ctim.2025.103302","DOIUrl":"10.1016/j.ctim.2025.103302","url":null,"abstract":"<div><h3>Purpose</h3><div>Percutaneous coronary intervention (PCI) is one of the most important therapies in patients with coronary heart disease (CHD). However, there are still many problems, such as in-stent restenosis, recurrent angina pectoris, postoperative anxiety and depression. Traditional Chinese exercise (TCE) therapies belong to the aerobic exercise of low and medium intensity which movements are soft and the combination of movement and static, which may have a certain efficacy on cardiac rehabilitation of patients after PCI. Therefore, this study systematically reviewed the reported clinical studies of TCE on cardiac rehabilitation in patients after PCI to explore its efficacy and safety.</div></div><div><h3>Methods</h3><div>We searched for RCTs on patients after PCI in 8 Chinese and English databases from their inception to Aug 2024. We included patients after PCI, with the intervention group receiving TCE (alone and/or combined with conventional treatment and/or exercise) and the control group receiving only conventional treatment and/or exercise. We screened the literatures and extracted the data. And we used the Cochrane “Risk of bias” tool and GRADE tool to assess the quality of studies and evidence. We used RevMan 5.4 to analyze the results.</div></div><div><h3>Results</h3><div>Fifty-three studies involving 4700 patients after PCI were included. TCE therapy includes Baduanjin, Tai Chi, Wuqinxi and Yi Jinjing. Conventional treatment(CT) included basic drugs, routine nursing, nutritional guidance and psychological intervention. Conventional exercise (CE) included walking, jogging or other aerobic exercise, resistance training, balance and flexibility training. Methodological quality was of high risk of bias in blinding of participants and personnel as well as unclear of bias in blinding of outcome assessment and allocation concealment. Grade evaluation results suggested low or very low quality of evidence. For the incidence of major adverse cardiovascular events rate, left ventricular ejection fraction, NT-ProBNP, six-minute walk distance, left ventricular end diastolic diameter, left ventricular end-systolic diameter, VO₂ max, anaerobic threshold, metabolite equivalents, seattle angina questionnaire and short form 36 health survey questionnaire, treatment group is superior to control group (P＜0.05). For VO₂ peak, there was no significant difference between the two groups (P＞0.05).</div></div><div><h3>Conclusions</h3><div>The results of this study showed that TCE may have efficacy in reducing the incidence of MACE, improving the cardiac function, exercise endurance and quality of life of patients after PCI. And the efficacy of the TCE therapy combined with CT and/or CE may be better than that of the CT and/or CE and the safety may be better.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103302"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary therapies for chronic knee pain: A placebo-controlled RCT of Reiki and mindfulness","authors":"Adam W. Hanley ,&nbsp;Yoshio Nakamura ,&nbsp;Robert R. Edwards ,&nbsp;Ayaka Lingard ,&nbsp;Kennedi Childs ,&nbsp;Jim Faulkner ,&nbsp;Ruthie Schnitt ,&nbsp;Samantha Vaca-St. Claire ,&nbsp;Elizabeth Bridge ,&nbsp;Eric L. Garland","doi":"10.1016/j.ctim.2025.103278","DOIUrl":"10.1016/j.ctim.2025.103278","url":null,"abstract":"<div><h3>Context</h3><div>Knee osteoarthritis (KOA) is a prevalent chronic pain condition that significantly impairs quality of life and is often treated with interventions that carry risks or provide limited relief. Reiki, a non-invasive complementary therapy, has shown early promise for pain management but lacks rigorous evaluation among American adults with KOA.</div></div><div><h3>Objectives</h3><div>This study evaluated the specific efficacy of Reiki and mindfulness for adults with chronic KOA pain compared to sham and waitlist control conditions.</div></div><div><h3>Methods</h3><div>In this placebo-controlled randomized trial, 164 adults with physician-confirmed KOA were assigned to one of four groups: Reiki, sham Reiki (i.e., Feiki), mindfulness meditation, or a waitlist control. Active treatments were delivered in four weekly 30-minute sessions.</div></div><div><h3>Results</h3><div>KOA symptom severity, assessed using the WOMAC at baseline, 1-month, and 2-month follow-ups, significantly improved in both the Reiki (<em>p</em> = .02) and mindfulness (p &lt; .001) groups compared to waitlist controls. Mindfulness significantly outperformed Feiki (<em>p</em> = .004). Reiki demonstrated effects comparable to mindfulness (p = .22). Clinically meaningful reductions in symptoms (&gt;30 %) were reported by 55 % of participants in the Reiki and mindfulness groups, compared to 20 % in the Feiki group and 13 % in the waitlist group. High retention (96 %) and successful blinding support the feasibility and internal validity of this approach.</div></div><div><h3>Conclusions</h3><div>These findings indicate that both Reiki and mindfulness may offer effective, well-tolerated, and time-efficient alternatives for managing KOA-related pain, with meaningful symptom improvement after just two hours of intervention. Larger trials are warranted to confirm efficacy and explore long-term outcomes and underlying mechanisms.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103278"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of exercise interventions on sleep quality in patients with emotion-related insomnia (ERI)：A systematic review and network meta-analysis","authors":"Baoyi Ouyang ,&nbsp;Jianan Gao ,&nbsp;Xiaojie Zhou ,&nbsp;Liang Gao ,&nbsp;Hui He","doi":"10.1016/j.ctim.2025.103298","DOIUrl":"10.1016/j.ctim.2025.103298","url":null,"abstract":"<div><div>This meta-analysis consequently endeavors to methodically evaluate the impact of exercise interventions on sleep quality measures in populations affected by ERI.The study intends to develop an evidence-based prioritization framework for exercise types, offering support for the customization of exercise prescriptions in clinical practice.</div></div><div><h3>Methods</h3><div>This study was evaluated by literature search in five databases, and analyses were subsequently conducted using Review Manager 5.3 and STATA 18.0. Furthermore, a meta-regression analysis was employed to examine the potential moderating effects of exercise intervention characteristics.</div></div><div><h3>Results</h3><div>Pairwise meta-analysis demonstrated that exercise significantly improved subjective sleep quality [SMD = -0.83, (95 % CI = −1.17, −0.49),P &lt; 0.001].Network meta-analysis revealed that several exercise types are potentially effective interventions for enhancing subjective sleep quality: aerobic exercise (AE) (SMD = −0.66, 95 % CI: −1.19, −0.14, p &lt; 0.05), combined exercise (CE) (SMD = −1.17, 95 % CI: −2.07, −0.26, p &lt; 0.05), and Body and mind exercise (BM) (SMD = −0.71, 95 % CI: −1.35, −0.07, p &lt; 0.05). Among these, CE [SMD = -1.17, 95 % CI: −2.07, −0.26, p &lt; 0.05; SUCRA = 77.9 %] was identified as the most likely modality for improving subjective sleep quality.Meta-regression analysis indicated that exercise cycles (β = −0.470, p &lt; 0.05) and exercise frequency (β = −0.940, p &lt; 0.05) may be significant moderators influencing the effect of exercise on sleep onset latency (SOL).</div></div><div><h3>Conclusion</h3><div>Exercise was effective in improving subjective sleep quality.CE, AE, and BM may represent preferential modalities for enhancing subjective sleep quality, with CE potentially constituting the most effective intervention.exercise frequency and exercise cycles are identified as potential significant moderators influencing the improvement of SOL.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103298"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of turmeric for the treatment of COVID-19: An updated systematic review and meta-analysis of randomized controlled trials","authors":"Ratree Sawangjit ,&nbsp;Saranrat Sadoyu ,&nbsp;Siripong Manosanthipaibul ,&nbsp;Nattawat Teerawattanapong ,&nbsp;Panupong Puttarak ,&nbsp;Kulthanit Wanaratna ,&nbsp;Rawiwan Charoensup ,&nbsp;Poonsit Hiransai ,&nbsp;Thunyaluk Meetam ,&nbsp;Nathorn Chaiyakunapruk","doi":"10.1016/j.ctim.2025.103295","DOIUrl":"10.1016/j.ctim.2025.103295","url":null,"abstract":"<div><div>We conducted a comprehensive and updated systematic review and meta-analysis (SR-MA) to determine the effectiveness and safety of turmeric in patients with coronavirus disease 2019 (COVID-19). Multiple databases were searched from inception to July 31, 2024, for randomized controlled trials (RCTs) assessing turmeric in mild to severe COVID-19. This SR-MA uniquely includes recent trials conducted alongside modern antiviral-based regimens and explores effect modifiers by disease severity, comorbidity, formulation, and treatment duration. Twenty-three RCTs with 1407 participants were included, making this the largest synthesis to date. Most studies (17/23, 73.9 %) enrolled hospitalized patients; over half involved mild to moderate cases. The most common intervention was nano-curcumin 160–240 mg/day (39 %), used as an adjunct to standard care. Nine studies were rated high risk of bias (ROB). Meta-analysis showed turmeric significantly reduced all-cause mortality (Relative risk (RR) = 0.39; 95 % confidence interval (95 %CI): 0.23–0.67; <em>I</em>² = 0 %; n = 8 RCTs; moderate certainty), suggesting a 61 % reduction in risk of death. It also reduced the need for intubation/mechanical ventilation (RR = 0.35; 95 %CI: 0.17–0.72) and clinical deterioration (RR=0.36; 95 %CI: 0.22–0.59), while improving overall symptom resolution (RR = 1.36; 95 %CI: 1.16–1.59). These results remained robust after excluding high ROB studies. Adverse events, mostly mild gastrointestinal symptoms, were comparable to placebo. In conclusion, turmeric, particularly bioavailability-enhanced nano-curcumin, provides meaningful clinical benefits and favorable safety profile as adjunctive therapy for COVID-19. Further large-scale, high-quality, multicenter RCTs are warranted to confirm its therapeutic potential, particularly in resource-limited settings.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103295"},"PeriodicalIF":3.5,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}