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Traditional Chinese exercises for the treatment of neuropsychiatric symptoms in Parkinson’s disease: A systematic review and meta-analysis
IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-01-20 DOI: 10.1016/j.ctim.2025.103134
Weiqiang Tan , Zhaoquan Pan , Jiawei He , Tiexiong Wu , Feng Wu , Yachen Xu , Lisha Liu , Ziyu Yang , Chunrui Li , Yuechen Hu , Muxi Liao
<div><h3>Objective</h3><div>To systematically evaluate the efficacy of traditional Chinese exercises (TCEs) for neuropsychiatric symptoms (NPSs) in patients with Parkinson’s disease.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was performed across eight databases, including PubMed, Cochrane Library, Embase, Web of Science (WoS), SinoMed, China National Knowledge Infrastructure (CNKI), China Science and Technology Periodical Database (VIP), and Wanfang Database, covering studies published from their inception up to April 23, 2024. The search focused on identifying randomized controlled trials (RCTs) assessing the effectiveness of TCEs for NPSs in PD patients.</div><div>The authors independently performed literature screening and data extraction. Meta-analysis was executed employing Review Manager V.5.3 software, and Stata 17.0 was used to detect publication bias and perform sensitivity analysis. GRADEpro GDT was used to grade the certainty of each outcome evidence.</div></div><div><h3>Results</h3><div>Eighteen studies involving 937 participants were included. The meta-analysis showed significant improvements in depression-related scales (standardized mean difference (SMD) = –1.30, 95 % confidence interval (CI): –2.10 to –0.49, <em>p</em> = 0.002), anxiety-related scales (SMD = –1.11, 95 %CI: –2.14 to –0.08, <em>p</em> = 0.03), sleep disorder-related scales (SMD = –0.71, 95 %CI: –0.99 to –0.43, <em>p</em> < 0.00001), and cognition-related scales (SMD = 0.91, 95 %CI: 0.44–1.38, <em>p</em> = 0.0001). Quality of life also improved (SMD = –1.35, 95 % CI: –2.38 to –0.31, <em>p</em> = 0.01; SMD = 0.99, 95 % CI: 0.54–1.43, <em>p</em> < 0.0001). Subgroup analyses grounded in the duration of the intervention suggested that interventions lasting up to 12 weeks showed more significant anti-depression and anti-anxiety effects while those lasting beyond 12 weeks demonstrated greater improvements in sleep quality and cognitive function. Additionally, subgroup analyses based on the type of intervention revealed that both using TCEs alone and the combination of TCEs with conventional medications showed greater effects on anti-depression and cognitive function, while the latter yield more significant anti-anxiety effects. However, no statistical significance was found for fatigue-related scales. The clinical trials included in this review also lacked a thorough description of the randomization process, and only a small proportion reported adequate allocation concealment procedures, raising concerns about potential selection bias. Moreover, owing to the inherent characteristics of TCEs, blinding both participants and practitioners is challenging, which may result in performance bias. Additionally, the absence of blinding could allow assessors’ subjective influences to affect the outcomes, leading to detection bias. The overall quality of the evidence, as assessed according to the GRADE criteria, was rated as very low or low for most
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引用次数: 0
The efficacy and safety of Baduanjin exercise as complementary therapy for pain reduction and functional improvement in knee osteoarthritis: A meta-analysis of randomized controlled trials 八段锦运动辅助治疗膝关节骨性关节炎的疗效和安全性:一项随机对照试验的meta分析。
IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-01-17 DOI: 10.1016/j.ctim.2025.103127
Ye Tian , Zi-Yuan Liu , Jia-Hao Wang , Jing-Hua Qian

Objectives

To systematically evaluate the efficacy and safety of Baduanjin exercise in patients with knee osteoarthritis through meta-analysis. While Baduanjin exercise, a traditional Chinese exercise therapy, is part of complementary and alternative medicine, its therapeutic value for knee osteoarthritis remains uncertain due to limited supporting evidence. This study seeks to address this gap.

Methods

The study protocol has been registered in PROSPERO(CRD42024501559). A systematic review and meta-analysis were conducted by searching six databases up to January 2024 (PubMed, Cochrane Library, EBSCO, Web of Science and CNKI, and Wanfang Medical), including RCTs that assessed Baduanjin exercise for KOA treatment. Two reviewers independently selected studies, extracted data, and assessed risk of bias using the Cochrane Risk of Bias tool (RoB2). Meta-analyses were performed using RevMan version 5.4.1 software. The outcome indicators included the WOMAC knee pain score, stiffness score, and physical function score, as well as the total score and adverse events. For summary results, weighted mean difference (MD) and 95 % confidence intervals (CI) were used.

Results

Twelve RCTs involving 846 participants were included. Baduanjin exercise significantly improved WOMAC pain score (MD=-2.59, 95 % CI: −4.20 to −0.97, P = 0.002), stiffness score (MD=-2.42, 95 % CI: −3.75 to - 1.08, P = 0.004), physical function score (MD=-4.42, 95 % CI: −5.67 to −3.17, P < 0.00001), and total score (MD=-11.27, 95 % CI: −14.26 to −8.28, P < 0.00001) compared to controls. Subgroup analyses revealed significant improvements regardless of intervention duration, frequency, or location. No adverse events were reported. However, high heterogeneity and methodological biases were observed.

Conclusion

Baduanjin exercise appears to be an effective and safe complementary therapy for improving pain and function in patients with KOA. High-quality RCTs are needed to confirm these findings and explore optimal intervention parameters. Future research should address the identified methodological limitations.
目的:通过meta分析,系统评价八段锦运动治疗膝骨性关节炎的疗效和安全性。八段筋作为一种中国传统的运动疗法,属于补充和替代医学的一部分,但由于证据有限,其对膝关节骨关节炎的治疗价值尚不确定。本研究旨在解决这一差距。方法:该研究方案已在PROSPERO注册(CRD42024501559)。通过检索截至2024年1月的6个数据库(PubMed、Cochrane Library、EBSCO、Web of Science and CNKI、万方医学)进行系统综述和meta分析,包括评估八段筋运动治疗KOA的随机对照试验。两位审稿人独立选择研究,提取数据,并使用Cochrane风险偏倚工具(RoB2)评估偏倚风险。采用RevMan 5.4.1版软件进行meta分析。结局指标包括WOMAC膝关节疼痛评分、僵硬评分和身体功能评分,以及总评分和不良事件。对于总结结果,使用加权平均差(MD)和95%置信区间(CI)。结果:纳入12项随机对照试验,共846名受试者。八段锦运动可显著改善WOMAC疼痛评分(MD=-2.59, 95% CI: -4.20 ~ -0.97, P=0.002)、僵硬评分(MD=-2.42, 95% CI: -3.75 ~ - 1.08, P=0.004)、身体功能评分(MD=-4.42, 95% CI: -5.67 ~ -3.17, P)。结论:八段锦运动是改善KOA患者疼痛和功能的有效、安全的补充疗法。需要高质量的随机对照试验来证实这些发现并探索最佳干预参数。未来的研究应解决已确定的方法学局限性。
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引用次数: 0
Acceptability of self-administered acupressure for knee osteoarthritis in middle-aged and older adults: A mixed-method secondary analysis 中老年人膝骨关节炎患者自我穴位按压的可接受性:一项混合方法的二次分析。
IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-01-17 DOI: 10.1016/j.ctim.2025.103130
Shu-Cheng Chen , Nicole Nok Leung , Hui-Lin Cheng , Min-Ru Wu , Denise Shuk-Ting Cheung , Jia-Yin Ruan , Jing Qin , Ge Ren , Wing-Fai Yeung

Objectives

To evaluate the acceptability of self-administered acupressure for Knee osteoarthritis (KOA) among middle-aged and older adults.

Methods

This is a mixed-method acceptability evaluation was embedded in a randomized controlled trial on self-administered acupressure for KOA. Participants received two 2-h training sessions on self-administered acupressure and were instructed to practice twice daily for 12 weeks. Quantitative data were collected using an acceptability questionnaire (n = 153) and acupressure logbooks (n = 157). Qualitative data were obtained through semi-structured interviews, including post-training (n = 13) and post-intervention focus groups (n = 13), and individual interviews with participants who dropped out (n = 5). Data were analysed using descriptive statistics and framework analysis based on the Theoretical Framework of Acceptability.

Results

The intervention had 91.7 % completion rate. Participants rated willingness to attend future sessions at 9.5/10 (SD=0.85). 57.8 % found technique education "very helpful" and 81.5 % followed the prescribed routine. Participants reported high overall acceptability of the self-administered acupressure training program, citing its practicality and potential benefits on knee pain, thigh strength, inflammation, and swelling. The minimal time and financial investment required were also appreciated. However, challenges related to personal efforts, time management, pressure from research monitoring, possible adverse events, and uncertainties with acupressure techniques were noted, leading to adherence issues. Participants expressed a need for continuous professional guidance.

Conclusion

Self-administered acupressure is highly acceptable to middle-aged and older adults with KOA due to its potential benefits and merits of minimal time and cost. Future research should focus on optimizing intervention implementation by providing professional support and efficient monitoring to address identified challenges.
目的:评价中老年人自行穴位按压治疗膝骨关节炎(KOA)的可接受性。方法:这是一种混合方法的可接受性评价,嵌入在一项随机对照试验中,对自我给药穴位按压治疗KOA。参与者接受了两次2小时的自我穴位按摩训练,并被指示每天练习两次,持续12周。采用可接受性问卷(n=153)和指压日志(n=157)收集定量数据。通过半结构化访谈获得定性数据,包括培训后(n=13)和干预后焦点小组(n=13),以及对退出参与者的个别访谈(n=5)。采用描述性统计和基于可接受性理论框架的框架分析法对数据进行分析。结果:干预完成率为91.7%。参与者对参加未来会议的意愿评分为9.5/10 (SD=0.85)。57.8%的人认为技术教育“非常有帮助”,81.5%的人遵循了规定的常规。参与者报告了自我管理的指压训练计划的高总体接受度,引用了它的实用性和对膝盖疼痛、大腿力量、炎症和肿胀的潜在益处。还赞赏所需的最少时间和财政投资。然而,与个人努力、时间管理、研究监测压力、可能的不良事件和穴位按压技术的不确定性相关的挑战被注意到,导致依从性问题。与会者表示需要持续的专业指导。结论:自我穴位按压对中老年KOA患者有较高的可接受性,其潜在的益处和时间、成本均较低。未来的研究应侧重于通过提供专业支持和有效监测来优化干预措施的实施,以应对已发现的挑战。
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引用次数: 0
The clinical efficacy of scalp acupuncture for tinnitus: A systematic review and meta-analysis 头皮针刺治疗耳鸣的临床疗效:系统回顾和荟萃分析。
IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-01-17 DOI: 10.1016/j.ctim.2025.103129
Jiadi Chen, Ruizhi Jing

Background

No single treatment is considered to be universally effective for tinnitus. Scalp acupuncture has been explored as a potential treatment.

Objective

This systematic review and meta-analysis aim to evaluate the clinical efficacy of scalp acupuncture in treating tinnitus.

Methods

A comprehensive search of relevant databases was conducted to identify randomized controlled trials comparing scalp acupuncture with a control treatment for tinnitus.The clinical efficacy rate and reduction in tinnitus severity were assessed using relative risk (RR) and standardized mean difference (SMD), respectively. Sensitivity analyses was performed to investigate sources of heterogeneity.

Results

A total of 20 research studies,with 1430 participants,were included.The systematic review and meta-analysis revealed that the scalp acupuncture groups had a significantly higher clinical effective rate compared to the control groups (RR=1.25, 95 % CI 1.16–1.35, p < 0.00001),with low heterogeneity(p = 0.27,I2=20 %).The scalp acupuncture groups and scalp acupuncture plus auxiliary acupoints groups had greater reduction in tinnitus severity compared to the control groups(SMD=-0.76,95 %CI:-1.02,-0.51,p < 0.00001;SMD:-0.93,95 %CI:-1.52,-0.33,p = 0.002, respectively),with a moderate heterogeneity(p = 0.005,I2=62 %) and a significant heterogeneity (p < 0.00001,I2=86 %) observed due to differences in study design, sample characteristics, and intervention protocols.Sensitivity analysis confirmed the stability of the results.The summary table generated through GRADEpro indicated that the certainty of evidence ranged from moderate to low.

Conclusions

Scalp acupuncture has demonstrated promising efficacy in the treatment of tinnitus compared to traditional acupuncture or pharmacotherapy. However, the current evidence is limited due to potential biases and heterogeneity across studies.Future studies should standardize protocols, ensure higher methodological rigor, and explore long-term effects to validate the findings further.
The review was registered with PROSPERO (CRD42024537806):Jiadi Chen, Ruizhi Jing.Analysis of clinical effect of scalp acupuncture on tinnitus. Available
from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024537806.
背景:没有一种治疗耳鸣的方法被认为是普遍有效的。头皮针灸作为一种潜在的治疗方法已被探索。目的:本系统综述和荟萃分析旨在评价头皮针刺治疗耳鸣的临床疗效。方法:对相关数据库进行全面检索,以确定比较头皮针刺与对照治疗耳鸣的随机对照试验。分别采用相对危险度(RR)和标准化平均差(SMD)评价临床有效率和耳鸣严重程度的降低。进行敏感性分析以调查异质性的来源。结果:共纳入20项研究,1430名受试者。系统评价和荟萃分析显示,头皮针刺组的临床有效率显著高于对照组(RR=1.25, 95 % CI 1.16-1.35, p 2=20 %)。与对照组相比,头皮针刺组和头皮针刺加辅助穴位组耳鸣严重程度的降低更大(SMD=-0.76,95 %CI:-1.02,-0.51,p 2=62 %),由于研究设计、样本特征和干预方案的差异,观察到显著的异质性(p 2=86 %)。敏感性分析证实了结果的稳定性。通过GRADEpro生成的汇总表显示,证据的确定性从中等到低不等。结论:头皮针刺治疗耳鸣较传统针刺或药物治疗有较好的疗效。然而,由于潜在的偏倚和研究的异质性,目前的证据是有限的。未来的研究应使方案标准化,确保更高的方法严谨性,并探索长期影响以进一步验证研究结果。该综述已在普洛斯彼罗注册(CRD42024537806):陈佳迪,景瑞智。头皮针刺治疗耳鸣的临床疗效分析。可从:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024537806。
{"title":"The clinical efficacy of scalp acupuncture for tinnitus: A systematic review and meta-analysis","authors":"Jiadi Chen,&nbsp;Ruizhi Jing","doi":"10.1016/j.ctim.2025.103129","DOIUrl":"10.1016/j.ctim.2025.103129","url":null,"abstract":"<div><h3>Background</h3><div>No single treatment is considered to be universally effective for tinnitus. Scalp acupuncture has been explored as a potential treatment.</div></div><div><h3>Objective</h3><div>This systematic review and meta-analysis aim to evaluate the clinical efficacy of scalp acupuncture in treating tinnitus.</div></div><div><h3>Methods</h3><div>A comprehensive search of relevant databases was conducted to identify randomized controlled trials comparing scalp acupuncture with a control treatment for tinnitus.The clinical efficacy rate and reduction in tinnitus severity were assessed using relative risk (RR) and standardized mean difference (SMD), respectively. Sensitivity analyses was performed to investigate sources of heterogeneity.</div></div><div><h3>Results</h3><div>A total of 20 research studies,with 1430 participants,were included.The systematic review and meta-analysis revealed that the scalp acupuncture groups had a significantly higher clinical effective rate compared to the control groups (RR=1.25, 95 % CI 1.16–1.35, <em>p</em> &lt; 0.00001),with low heterogeneity(<em>p</em> = 0.27,I<sup>2</sup>=20 %).The scalp acupuncture groups and scalp acupuncture plus auxiliary acupoints groups had greater reduction in tinnitus severity compared to the control groups(SMD=-0.76,95 %CI:-1.02,-0.51,<em>p</em> &lt; 0.00001;SMD:-0.93,95 %CI:-1.52,-0.33,<em>p</em> = 0.002, respectively),with a moderate heterogeneity(<em>p</em> = 0.005,I<sup>2</sup>=62 %) and a significant heterogeneity (<em>p</em> &lt; 0.00001,I<sup>2</sup>=86 %) observed due to differences in study design, sample characteristics, and intervention protocols.Sensitivity analysis confirmed the stability of the results.The summary table generated through GRADEpro indicated that the certainty of evidence ranged from moderate to low.</div></div><div><h3>Conclusions</h3><div>Scalp acupuncture has demonstrated promising efficacy in the treatment of tinnitus compared to traditional acupuncture or pharmacotherapy. However, the current evidence is limited due to potential biases and heterogeneity across studies.Future studies should standardize protocols, ensure higher methodological rigor, and explore long-term effects to validate the findings further.</div><div>The review was registered with PROSPERO (CRD42024537806):Jiadi Chen, Ruizhi Jing.Analysis of clinical effect of scalp acupuncture on tinnitus. Available</div><div>from: <span><span>https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024537806</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"88 ","pages":"Article 103129"},"PeriodicalIF":3.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of non-pharmacological interventions on chemotherapy induced delayed nausea and vomiting for tumors: A systematic review and Bayesian network meta-analysis 非药物干预对肿瘤化疗引起的延迟性恶心和呕吐的影响:一项系统综述和贝叶斯网络meta分析。
IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-01-10 DOI: 10.1016/j.ctim.2024.103124
Yongni Wang , Fang Wang , Feifei Hu , Fang Long

Objective

To evaluate the efficacy of non-pharmacological interventions in improving chemotherapy induced delayed nausea and vomiting symptoms using a network meta-analysis.

Methods

Four Chinese databases (CNKI, Wanfang Data Knowledge Service Platform, VIP, Sinomed) and five English databases (PubMed, Cochrane Library, Embase, Web of Science, CINAHL) were searched from the establishment of the database to April 2024. A Bayesian network meta-analysis was performed on the response rate to the improvement of chemotherapy induced delayed nausea and vomiting, as well as improvement in KPS score, under different non-pharmacological interventions by using R 4.4.0 software and the GeMTC package.

Results

A total of 58 RCTs 4081 patients were selected, involving 14 non-pharmacological interventions. The results of Meta-analysis showed that acupoint patch was identified as the most probable superior intervention in the improvement of chemotherapy induced delayed nausea and vomiting, and acupuncture was identified as the most probable superior intervention on the improvement of KPS scores.

Conclusion

Non-pharmacological interventions can serve as an effective complementary approach to managing delayed chemotherapy-induced nausea and vomiting. In particular, acupoint application may be the optimal complementary therapy to mitigate the incidence of delayed nausea and vomiting, though more high-quality, large-scale evidence is required to conclusively demonstrate the efficacy of acupuncture in enhancing the quality of life for cancer patients.
目的:通过网络荟萃分析评估非药物干预对改善化疗诱导的延迟性恶心和呕吐症状的疗效。方法:检索自建库至2024年4月的4个中文数据库(CNKI、万方数据知识服务平台、VIP、Sinomed)和5个英文数据库(PubMed、Cochrane Library、Embase、Web of Science、CINAHL)。采用r4.1.3软件和GeMTC软件包,对不同非药物干预下化疗所致延迟性恶心呕吐改善的有效率及KPS评分改善情况进行贝叶斯网络meta分析。结果:共纳入58项rct 4081例患者,涉及14项非药物干预措施。meta分析结果显示,穴位贴片被认为是改善化疗引起的延迟性恶心和呕吐最可能的优越干预措施,针刺被认为是改善KPS评分最可能的优越干预措施。结论:非药物干预可以作为治疗延迟化疗引起的恶心和呕吐的有效补充方法。特别是,穴位应用可能是减轻延迟性恶心和呕吐发生率的最佳补充疗法,尽管需要更多高质量、大规模的证据来结论性地证明针灸在提高癌症患者生活质量方面的有效性。
{"title":"Effect of non-pharmacological interventions on chemotherapy induced delayed nausea and vomiting for tumors: A systematic review and Bayesian network meta-analysis","authors":"Yongni Wang ,&nbsp;Fang Wang ,&nbsp;Feifei Hu ,&nbsp;Fang Long","doi":"10.1016/j.ctim.2024.103124","DOIUrl":"10.1016/j.ctim.2024.103124","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of non-pharmacological interventions in improving chemotherapy induced delayed nausea and vomiting symptoms using a network meta-analysis.</div></div><div><h3>Methods</h3><div>Four Chinese databases (CNKI, Wanfang Data Knowledge Service Platform, VIP, Sinomed) and five English databases (PubMed, Cochrane Library, Embase, Web of Science, CINAHL) were searched from the establishment of the database to April 2024. A Bayesian network meta-analysis was performed on the response rate to the improvement of chemotherapy induced delayed nausea and vomiting, as well as improvement in KPS score, under different non-pharmacological interventions by using R 4.4.0 software and the GeMTC package.</div></div><div><h3>Results</h3><div>A total of 58 RCTs 4081 patients were selected, involving 14 non-pharmacological interventions. The results of Meta-analysis showed that acupoint patch was identified as the most probable superior intervention in the improvement of chemotherapy induced delayed nausea and vomiting, and acupuncture was identified as the most probable superior intervention on the improvement of KPS scores.</div></div><div><h3>Conclusion</h3><div>Non-pharmacological interventions can serve as an effective complementary approach to managing delayed chemotherapy-induced nausea and vomiting. In particular, acupoint application may be the optimal complementary therapy to mitigate the incidence of delayed nausea and vomiting, though more high-quality, large-scale evidence is required to conclusively demonstrate the efficacy of acupuncture in enhancing the quality of life for cancer patients.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"88 ","pages":"Article 103124"},"PeriodicalIF":3.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of probiotics on C-reactive protein levels in schizophrenia: Evidence from a systematic review and meta-analysis 益生菌对精神分裂症患者c -反应蛋白水平的影响:来自系统回顾和荟萃分析的证据。
IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-01-09 DOI: 10.1016/j.ctim.2025.103126
Verónica Romero-Ferreiro , Lorena García-Fernández , José Miguel Biscaia , Carmen Romero , Rocío González-Soltero , Mónica De la Fuente , Miguel A. Álvarez-Mon , Rolf Wynn , Roberto Rodriguez-Jimenez

Background

Inflammatory markers play a pivotal role in schizophrenia, as they provide insight into the neuroinflammatory processes occurring in the context of the disorder. Elevated levels of these markers, particularly C-reactive protein (CRP), can indicate an underlying immune system dysregulation, potentially influencing symptom severity and progression. Recognizing these markers has led to investigate the use of probiotics as an adjuvant to improve the treatment of schizophrenia. The main objective of this study is to rigorously evaluate the efficacy of probiotics in reducing plasma levels of CRP in patients with schizophrenia.

Methods

A systematic search and meta-analysis were conducted to review randomized clinical trials following the PRISMA methodology. The following search strategy ((SCHIZO* OR PSYCHOTIC OR PSYCHOSES) AND (PROBIOTIC* OR BIFIDOBACTER* OR LACTOBACILL*)) was used for searching publications between June-December 2024 on the PubMed, Web of Science, and APA PsycINFO databases. Individual study quality was assessed with the Cochrane risk of bias (RoB2) and the certainty of total evidence was assessed with the GRADE system.

Results

The primary outcome assessed was the impact of probiotic supplementation on plasma CRP levels. Out of 78 studies initially identified, 4 were finally included in the meta-analysis. Three out four studies found a significant reduction in high-sensitivity C-reactive protein levels in the supplemented compared with the placebo group. The pooled analysis revealed a significant reduction in CRP levels with probiotic supplementation, with a standardized mean difference (SMD) of −0.46, (95 % CI −0.719; −0.201; p = 0.001).

Conclusions

The synthesis and meta-analysis of available literature provide evidence for the potential role of probiotics in the reduction of serum CRP in schizophrenia compared with placebo. However, more clinical trials with better control of experimental design are needed before a clear recommendation as adjuvant therapy can be made.
背景:炎症标志物在精神分裂症中起着关键作用,因为它们提供了对精神分裂症背景下发生的神经炎症过程的洞察。这些标志物,特别是c反应蛋白(CRP)水平升高,可能表明潜在的免疫系统失调,可能影响症状的严重程度和进展。认识到这些标记导致研究使用益生菌作为辅助剂来改善精神分裂症的治疗。本研究的主要目的是严格评估益生菌在降低精神分裂症患者血浆CRP水平方面的疗效。方法:对采用PRISMA方法的随机临床试验进行系统检索和荟萃分析。以下搜索策略((SCHIZO* OR psychiatric OR PSYCHOSES)和(PROBIOTIC* OR BIFIDOBACTER* OR LACTOBACILL*))用于检索PubMed、Web of Science和APA PsycINFO数据库中2024年6月至12月之间的出版物。采用Cochrane偏倚风险(RoB2)评估个体研究质量,采用GRADE系统评估总证据的确定性。结果:评估的主要结果是益生菌补充对血浆CRP水平的影响。在最初确定的78项研究中,有4项最终纳入了荟萃分析。四分之三的研究发现,与安慰剂组相比,补充剂组的高敏c反应蛋白水平显著降低。合并分析显示,补充益生菌后CRP水平显著降低,标准化平均差异(SMD)为-0.46,(95% CI -0.719;-0.201;P = 0.001)。结论:对现有文献的综合和荟萃分析为益生菌与安慰剂相比在降低精神分裂症患者血清CRP方面的潜在作用提供了证据。然而,需要更多的临床试验和更好的实验设计控制,才能明确推荐作为辅助治疗。
{"title":"Effect of probiotics on C-reactive protein levels in schizophrenia: Evidence from a systematic review and meta-analysis","authors":"Verónica Romero-Ferreiro ,&nbsp;Lorena García-Fernández ,&nbsp;José Miguel Biscaia ,&nbsp;Carmen Romero ,&nbsp;Rocío González-Soltero ,&nbsp;Mónica De la Fuente ,&nbsp;Miguel A. Álvarez-Mon ,&nbsp;Rolf Wynn ,&nbsp;Roberto Rodriguez-Jimenez","doi":"10.1016/j.ctim.2025.103126","DOIUrl":"10.1016/j.ctim.2025.103126","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory markers play a pivotal role in schizophrenia, as they provide insight into the neuroinflammatory processes occurring in the context of the disorder. Elevated levels of these markers, particularly C-reactive protein (CRP), can indicate an underlying immune system dysregulation, potentially influencing symptom severity and progression. Recognizing these markers has led to investigate the use of probiotics as an adjuvant to improve the treatment of schizophrenia. The main objective of this study is to rigorously evaluate the efficacy of probiotics in reducing plasma levels of CRP in patients with schizophrenia.</div></div><div><h3>Methods</h3><div>A systematic search and meta-analysis were conducted to review randomized clinical trials following the PRISMA methodology. The following search strategy ((SCHIZO* OR PSYCHOTIC OR PSYCHOSES) AND (PROBIOTIC* OR BIFIDOBACTER* OR LACTOBACILL*)) was used for searching publications between June-December 2024 on the PubMed, Web of Science, and APA PsycINFO databases. Individual study quality was assessed with the Cochrane risk of bias (RoB2) and the certainty of total evidence was assessed with the GRADE system.</div></div><div><h3>Results</h3><div>The primary outcome assessed was the impact of probiotic supplementation on plasma CRP levels. Out of 78 studies initially identified, 4 were finally included in the meta-analysis. Three out four studies found a significant reduction in high-sensitivity C-reactive protein levels in the supplemented compared with the placebo group. The pooled analysis revealed a significant reduction in CRP levels with probiotic supplementation, with a standardized mean difference (SMD) of −0.46, (95 % CI −0.719; −0.201; <em>p</em> = 0.001).</div></div><div><h3>Conclusions</h3><div>The synthesis and meta-analysis of available literature provide evidence for the potential role of probiotics in the reduction of serum CRP in schizophrenia compared with placebo. However, more clinical trials with better control of experimental design are needed before a clear recommendation as adjuvant therapy can be made.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103126"},"PeriodicalIF":3.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor on “Global research trends of sham acupuncture: A bibliometric analysis” 致编辑的信“假针的全球研究趋势:文献计量分析”。
IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-01-09 DOI: 10.1016/j.ctim.2025.103128
Zining Guo , Wenjing Zeng , Shaoyang Cui , Nenggui Xu
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引用次数: 0
Research hotspots and trends in the antioxidant effects of acupuncture: A bibliometric analysis from 2003 to 2024 针灸抗氧化作用的研究热点与趋势:2003 - 2024年文献计量学分析
IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-01-07 DOI: 10.1016/j.ctim.2024.103123
Zhilin Huang , Song Li , YiHao Zhou , Anhong Dai , Yi Zhang , Meifang Liu , Mengqi Le , Jing Shi

Objective

Oxidative stress is an important factor mediating the pathologic progression of many diseases. In recent years, the antioxidant effects of acupuncture have been gradually confirmed. However, bibliometric analysis in this field, which is still lacking. This study aimed to explore the current state of research and recent trends in the regulating of oxidative stress by acupuncture using bibliometric methods.

Methods

Articles pertaining to the acupuncture antioxidant effects were systematically retrieved from the Web of Science Core Collection database, encompassing the temporal scope from inception to September 6, 2024. Countries, publications, authors, co-citations, and keywords were visualized and analyzed using CiteSpace, VOSviewer, and R software.

Results

A total of 438 articles have been published in the field, with the number increasing yearly. Chinese scholars constitute a significant force in the domain of research pertaining to this field. Beijing University of Traditional Chinese Medicine is the institution with the highest number of publications. Cunzhi Liu (17) is the author with the highest number of publications. The journals with the most publications (39) and citations (652) are EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. Basic research is the main type of research. Both co-cited literature analysis and keyword examination have indicated neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke, as prominent research domains. Electroacupuncture is the most common intervention. Pain and inflammation may be a trend in research in this area.

Conclusion

This bibliometric analysis summarises the disease mapping and some of the mechanisms of acupuncture's antioxidant effects. Neurological disorders such as Parkinson's disease, vascular dementia, and stroke are major research areas in this field. Pain and inflammation may be a direction for future research.
目的:氧化应激是介导多种疾病病理进展的重要因素。近年来,针灸的抗氧化作用逐渐得到证实。然而,文献计量学分析在这一领域尚显不足。本研究旨在利用文献计量学方法探讨针刺调节氧化应激的研究现状和最新趋势。方法:系统地检索Web of Science Core Collection数据库中有关针灸抗氧化作用的文章,时间范围从建站到2024年9月6日。使用CiteSpace、VOSviewer和R软件对国家、出版物、作者、共被引和关键词进行可视化分析。结果:该领域共发表论文438篇,且逐年增加。中国学者在这一领域的研究中是一支重要的力量。北京中医药大学是发表论文数量最多的院校。刘存志(17岁)是发表论文数量最多的作者。发表论文最多(39篇)和被引用次数最多(652篇)的期刊是循证补充和替代医学。基础研究是研究的主要类型。共同被引文献分析和关键词检查都表明神经系统疾病,包括阿尔茨海默病、帕金森病和中风,是突出的研究领域。电针是最常见的干预手段。疼痛和炎症可能是这一领域研究的一个趋势。结论:本文献计量学分析总结了针灸抗氧化作用的疾病定位和一些机制。神经系统疾病,如帕金森病、血管性痴呆和中风是该领域的主要研究领域。疼痛和炎症可能是未来研究的一个方向。
{"title":"Research hotspots and trends in the antioxidant effects of acupuncture: A bibliometric analysis from 2003 to 2024","authors":"Zhilin Huang ,&nbsp;Song Li ,&nbsp;YiHao Zhou ,&nbsp;Anhong Dai ,&nbsp;Yi Zhang ,&nbsp;Meifang Liu ,&nbsp;Mengqi Le ,&nbsp;Jing Shi","doi":"10.1016/j.ctim.2024.103123","DOIUrl":"10.1016/j.ctim.2024.103123","url":null,"abstract":"<div><h3>Objective</h3><div>Oxidative stress is an important factor mediating the pathologic progression of many diseases. In recent years, the antioxidant effects of acupuncture have been gradually confirmed. However, bibliometric analysis in this field, which is still lacking. This study aimed to explore the current state of research and recent trends in the regulating of oxidative stress by acupuncture using bibliometric methods.</div></div><div><h3>Methods</h3><div>Articles pertaining to the acupuncture antioxidant effects were systematically retrieved from the Web of Science Core Collection database, encompassing the temporal scope from inception to September 6, 2024. Countries, publications, authors, co-citations, and keywords were visualized and analyzed using CiteSpace, VOSviewer, and R software.</div></div><div><h3>Results</h3><div>A total of 438 articles have been published in the field, with the number increasing yearly. Chinese scholars constitute a significant force in the domain of research pertaining to this field. Beijing University of Traditional Chinese Medicine is the institution with the highest number of publications. Cunzhi Liu (17) is the author with the highest number of publications. The journals with the most publications (39) and citations (652) are EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. Basic research is the main type of research. Both co-cited literature analysis and keyword examination have indicated neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke, as prominent research domains. Electroacupuncture is the most common intervention. Pain and inflammation may be a trend in research in this area.</div></div><div><h3>Conclusion</h3><div>This bibliometric analysis summarises the disease mapping and some of the mechanisms of acupuncture's antioxidant effects. Neurological disorders such as Parkinson's disease, vascular dementia, and stroke are major research areas in this field. Pain and inflammation may be a direction for future research.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"88 ","pages":"Article 103123"},"PeriodicalIF":3.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of virtual reality with or without hypnosis before oocyte retrieval: A randomised study 在卵母细胞提取前,有或没有催眠的虚拟现实的影响:一项随机研究。
IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-01-03 DOI: 10.1016/j.ctim.2024.103125
Céline Pirard , Pascale Laurent , Christine Wyns , Maria-Grazia Giudice , Christine Watremez , Mona Momeni , Fabienne Roelants

Objective of the study

Anxiety can affect pregnancy rate following an in-vitro-fertilisation procedure. Hypnosis reduces emotional distress associated with medical procedures. Virtual reality (VR) is an immersive 3D experience, created using a visual headset and headphones. The goal of this study was to evaluate the effect of VR session with and without hypnosis before sedation for oocyte retrieval (OR) on anxiety levels and on pregnancy rate.

Methods

After written informed consent, 342 women scheduled for OR under sedation were randomised in this double-blinded study (NCT03064061). A Visual Analogue Scale for anxiety (VAS) and a Spielberger State-Trait Anxiety Inventory (STAI) questionnaire before (baseline) and after VR session, and at hospital discharge were administered. VRD Group (n = 178) received a VR session (goal of distraction) and VRH group (n = 164) received the same VR session with hypnosis focused on slowing respiratory rhythm and suggestions of reusing the technique later as needed (AQUA Oncomfort/HypnoVR ™). The primary endpoint was ongoing pregnancy at 12 weeks. Mann Whitney, Wilcoxon signed rank test and Chi-square tests were used; p value < 0.05 considered significant.

Results

Although anxiety scores decreased from baseline in both VRD and VRH groups (p < 0.001 baseline vs post VR session and baseline vs hospital discharge), there was no difference between them. Nor was there a difference in pregnancy rate (18,6 % VRD group vs 22,5 % VRH group).

Conclusion

Although both VRD and VRH sessions before sedation for OR significantly reduced women's anxiety, the type of suggestions used during the hypnosis VR session did not influence the pregnancy rate.
研究目的:焦虑会影响体外受精手术后的妊娠率。催眠可以减少与医疗过程相关的情绪困扰。虚拟现实(VR)是一种身临其境的3D体验,使用视觉耳机和耳机创建。本研究的目的是评估在镇静取卵(OR)前有或没有催眠的VR会话对焦虑水平和妊娠率的影响。方法:在获得书面知情同意后,342名接受镇静或镇静治疗的女性被随机分配到这项双盲研究(NCT03064061)中。在VR治疗前(基线)、治疗后和出院时分别使用视觉焦虑模拟量表(VAS)和Spielberger状态-特质焦虑量表(STAI)。VRD组(n=178)接受了一个VR会话(目标是分散注意力),VRH组(n=164)接受了同样的VR会话,催眠的重点是减缓呼吸节奏,并建议以后在需要时重复使用该技术(AQUA Oncomfort/HypnoVR TM)。主要终点为妊娠12周。采用Mann Whitney、Wilcoxon符号秩检验和卡方检验;结果:尽管VRD组和VRH组的焦虑评分均较基线有所下降(p结论:尽管在镇静治疗OR前VRD和VRH均显著降低了女性的焦虑,但在催眠VR过程中使用的建议类型并未影响妊娠率。
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引用次数: 0
Is the topical application of sesame oil (Sesamum indicum L.) combined with standard care valuable and safe for managing infusion-related phlebitis: Evidence from a systematic review with meta-analysis of randomized controlled trials 局部应用芝麻油(Sesamum indicum L.)结合标准护理对管理输液相关性静脉炎有价值和安全吗:来自随机对照试验荟萃分析的系统评价证据
IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-12-30 DOI: 10.1016/j.ctim.2024.103122
Morteza Nasiri , Leila Amirmohseni , Mohammad Farzollah Abbasi , Fatemeh Yarahmadi , Sahar Zonoori , Mahya Torkaman , Elham Sadeghi Moghimi , Mehrnaz Ardaneh , Masoomeh Asadi

Objectives

Recent randomized controlled trials (RCTs) have studied the potential effect of the topical use of sesame oil (SO), obtained from the sesame plant seeds (Sesamum indicum L., Pedaliaceae family), in preventing or alleviating the symptoms of infusion-related phlebitis (IRP); nevertheless, their data are inconsistent. Thus, this review sought to qualitatively and quantitatively synthesize data from all available RCTs concerning the effect of the topical administration of SO on managing IRP.

Methods

The online databases were searched up to July 13, 2024. Studies were eligible if they compared administering standard care plus topical SO to applying an alternative modality and/or standard care. The Cochrane risk-of-bias tool and GRADE framework were employed to appraise the quality of the evidence.

Results

Eight studies of 755 records in the initial search met the inclusion criteria, which investigated inpatients and/or outpatients with chemotherapy-induced phlebitis (n = 6) and amiodarone-induced phlebitis (n = 2). According to the quantitative analysis, adults who had received coadministration of standard care and topical SO on the infusion site were significantly less affected by IRP than those who had received a control condition (effect sizes= 5, risk ratio= 0.54; 95 % confidence interval[0.32, 0.92]; P = 0.025). Also, based on the qualitative syntheses, SO can potentially prevent the formation of advanced stages of IRP, delay the appearance of IRP symptoms, and reduce IRP-induced pain severity.

Conclusion

Topical SO had a favorable effect on caring for adults with IRP. However, uncertainty remains because the evidence quality was moderate, some RCTs needed better methodological rigor, and most required to address the safety of the intervention or independent verification of SO used in terms of purity and potency. Thus, to build a valid conclusion about the efficacy and safety of SO in managing IRP, more high-quality RCTs must be conducted considering an active placebo control intervention along with a well-designed randomization and blinding approach, as well as a better description of safety parameters and the quality control information of the SO used.

PROSPERO Registration Number

CRD42024542497
目的:最近的随机对照试验(RCTs)研究了局部使用从芝麻植物种子(Sesamum indicum L., Pedaliaceae科)中提取的芝麻油(SO)在预防或缓解输液相关性静脉炎(IRP)症状中的潜在作用;然而,他们的数据并不一致。因此,本综述试图定性和定量地综合所有可用的随机对照试验的数据,这些数据涉及局部给药SO对治疗IRP的影响。方法:检索截至2024年7月13日的在线数据库。如果将标准护理加局部SO与替代方式和/或标准护理进行比较,则研究是合格的。采用Cochrane偏倚风险工具和GRADE框架评价证据质量。结果:初始检索的755条记录中有8项研究符合纳入标准,调查了住院和/或门诊化疗性静脉炎患者(n=6)和胺碘酮性静脉炎患者(n=2)。根据定量分析,与接受对照条件的成人相比,接受标准护理和输液部位局部SO联合给药的成人受IRP的影响显著小于接受对照条件的成人(效应量= 5,风险比= 0.54;95%置信区间]0.32,0.92[;P = 0.025)。此外,基于定性综合,SO可以潜在地阻止IRP晚期的形成,延缓IRP症状的出现,并降低IRP引起的疼痛严重程度。结论:外用SO对成人IRP患者有良好的护理效果。然而,不确定性仍然存在,因为证据质量一般,一些随机对照试验需要更好的方法严谨性,大多数需要解决干预的安全性或在纯度和效力方面使用的SO的独立验证。因此,为了建立关于SO治疗IRP的有效性和安全性的有效结论,必须进行更多高质量的随机对照试验,考虑有效的安慰剂对照干预,以及设计良好的随机化和盲法方法,以及对所使用SO的安全参数和质量控制信息的更好描述。普洛斯彼罗注册号:CRD42024542497。
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引用次数: 0
期刊
Complementary therapies in medicine
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