Pub Date : 2025-11-01Epub Date: 2025-10-07DOI: 10.1016/j.ctim.2025.103254
Mengqi Li , Guorui Ding , Ruobing Lan , Yu Li , Shuying Guan , Xiaolei Lu , Yuxing Zhang , Duo Zhao
Background
Constipation affects 75 % of children with cerebral palsy (CP). While massage is a safe non-invasive intervention, its clinical adoption remains limited due to insufficient evidence of its efficacy.
Objective
To evaluate the efficacy and safety of massage for CP-related constipation through meta-analysis.
Methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched seven databases for randomised controlled trials (RCTs) on pediatric CP-related constipation treated with massage. Eligible RCTs underwent Cochrane risk-of-bias assessment. Meta-analysis using Stata evaluated the overall efficacy, defecation parameters, and heterogeneity sources.
Results
A total of 11 RCTs involving 728 patients were included. The results of the meta-analysis showed that, compared with traditional therapy alone, massage was more effective in treating constipation in children with CP. This difference was statistically significant (p < 0.05), as evaluated by the overall effective rate (RR, Relative Risk = 1.23; 95 % CI, 95 % Confidence Interval = 1.14, 1.33), defecation frequency (MD, Mean Difference = 1.57; 95 % CI = 0.40, 2.75), defecation time (MD = -3.23; 95 % CI = -3.82, -2.64), and stool form score (SMD, Standardized Mean Difference = 0.66; 95 % CI = 0.39, 0.94), confirming the superior efficacy of massage over conventional therapy. However, both interventions showed comparable effects on defecation difficulty (p > 0.05). The baseline patient characteristics, duration and techniques of the massage, and efficacy of the control group intervention may be the sources of heterogeneity.
Conclusion
Massage therapy improves constipation symptoms in children with CP. These results require validation through larger, high-quality RCTs given the sample size limitations of the current study.
背景：便秘影响75%的脑瘫（CP）患儿。虽然按摩是一种安全的非侵入性干预，但由于其有效性证据不足，其临床应用仍然有限。目的：通过meta分析，评价推拿治疗cp相关性便秘的疗效和安全性。方法：根据系统评价和荟萃分析的首选报告项目（PRISMA）指南，我们检索了7个数据库，检索了按摩治疗小儿cp相关便秘的随机对照试验（RCTs）。符合条件的随机对照试验进行Cochrane风险偏倚评估。meta分析使用Stata评估总体疗效、排便参数和异质性来源。结果：共纳入11项rct， 728例患者。meta分析结果显示，与单纯传统疗法相比，推拿治疗CP患儿便秘更有效，总有效率（RR, Relative Risk = 1.23, 95% CI， 95%可信区间= 1.14,1.33）、排便频率（MD, Mean difference = 1.57, 95% CI = 0.40, 2.75）、排便时间（MD = -3.23, p < 0.05），差异有统计学意义（p < 0.05）。95% CI = -3.82, -2.64)，粪便形态评分（SMD，标准化平均差= 0.66;95% CI = 0.39, 0.94），证实按摩优于常规治疗。然而，两种干预措施对排便困难的影响相当（p < 0.05）。患者的基线特征、按摩的持续时间和手法以及对照组干预的效果可能是异质性的来源。结论：按摩治疗可改善CP患儿的便秘症状。鉴于当前研究的样本量限制，这些结果需要通过更大、高质量的随机对照试验来验证。
{"title":"Effectiveness of massage therapy for constipation in children with cerebral palsy: A systematic review and meta-analysis","authors":"Mengqi Li , Guorui Ding , Ruobing Lan , Yu Li , Shuying Guan , Xiaolei Lu , Yuxing Zhang , Duo Zhao","doi":"10.1016/j.ctim.2025.103254","DOIUrl":"10.1016/j.ctim.2025.103254","url":null,"abstract":"<div><h3>Background</h3><div>Constipation affects 75 % of children with cerebral palsy (CP). While massage is a safe non-invasive intervention, its clinical adoption remains limited due to insufficient evidence of its efficacy.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy and safety of massage for CP-related constipation through meta-analysis.</div></div><div><h3>Methods</h3><div>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched seven databases for randomised controlled trials (RCTs) on pediatric CP-related constipation treated with massage. Eligible RCTs underwent Cochrane risk-of-bias assessment. Meta-analysis using Stata evaluated the overall efficacy, defecation parameters, and heterogeneity sources.</div></div><div><h3>Results</h3><div>A total of 11 RCTs involving 728 patients were included. The results of the meta-analysis showed that, compared with traditional therapy alone, massage was more effective in treating constipation in children with CP. This difference was statistically significant (<em>p < 0.05</em>), as evaluated by the overall effective rate (RR, Relative Risk = 1.23; 95 % CI, 95 % Confidence Interval = 1.14, 1.33), defecation frequency (MD, Mean Difference = 1.57; 95 % CI = 0.40, 2.75), defecation time (MD = -3.23; 95 % CI = -3.82, -2.64), and stool form score (SMD, Standardized Mean Difference = 0.66; 95 % CI = 0.39, 0.94), confirming the superior efficacy of massage over conventional therapy. However, both interventions showed comparable effects on defecation difficulty (<em>p > 0.05</em>). The baseline patient characteristics, duration and techniques of the massage, and efficacy of the control group intervention may be the sources of heterogeneity.</div></div><div><h3>Conclusion</h3><div>Massage therapy improves constipation symptoms in children with CP. These results require validation through larger, high-quality RCTs given the sample size limitations of the current study.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103254"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-10-01DOI: 10.1016/j.ctim.2025.103253
Lili Mo , Diying Liao , Jianwei She , Bangbang Yan , Maowei Chen
Objective
The objective of this study was to systematically analyze the effects of different dance or dance integrated with other modalities on depressed patients in China to identify the most effective dance-based intervention.
Methods
Eight databases were searched for screening randomized controlled trials. Quality assessment was performed with the Rob-2 and network meta-analysis was conducted with Stata 17.0.
Results
Nineteen studies were included. Dance movement therapy(DMT) combined with Chinese dance elements(CDE) was ranked as the most effective intervention for depression (SUCRA=99.7 %). DMT combined with drugs was the most effective intervention for anxiety (SUCRA=87.7 %) and self-efficacy (SUCRA=78.8 %). Drawing therapy combined with dance intervention and drugs was the most effective intervention for improving quality of life (SUCRA=98.2 %). DMT combined with psychological intervention and drugs was the most effective intervention for positive coping (SUCRA=90.9 %). Egger’s test confirmed the robustness of this research.
Conclusions
DMT combined with CDE demonstrated the highest efficacy in improving depression, highlighting the importance of incorporating regional culture into dance therapy. DMT combined with drugs showed the most substantial improvements in anxiety and self-efficacy, reinforcing the recommendation that patients should keep pharmacological treatment. Drawing therapy combined with dance intervention and drugs had the most significant impact on quality of life, suggesting that patients should be encouraged to do more activities. DMT combined with psychological intervention and drugs was the most effective for positive coping. This indicates that psychological counseling is also important. To address multifaceted challenges, targeted intervention should be developed to meet diverse and complex needs comprehensively for patients.
{"title":"Effects of dance intervention on health-related outcomes in patients with depression in Mainland China: A network meta-analysis","authors":"Lili Mo , Diying Liao , Jianwei She , Bangbang Yan , Maowei Chen","doi":"10.1016/j.ctim.2025.103253","DOIUrl":"10.1016/j.ctim.2025.103253","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to systematically analyze the effects of different dance or dance integrated with other modalities on depressed patients in China to identify the most effective dance-based intervention.</div></div><div><h3>Methods</h3><div>Eight databases were searched for screening randomized controlled trials. Quality assessment was performed with the Rob-2 and network meta-analysis was conducted with Stata 17.0.</div></div><div><h3>Results</h3><div>Nineteen studies were included. Dance movement therapy(DMT) combined with Chinese dance elements(CDE) was ranked as the most effective intervention for depression (SUCRA=99.7 %). DMT combined with drugs was the most effective intervention for anxiety (SUCRA=87.7 %) and self-efficacy (SUCRA=78.8 %). Drawing therapy combined with dance intervention and drugs was the most effective intervention for improving quality of life (SUCRA=98.2 %). DMT combined with psychological intervention and drugs was the most effective intervention for positive coping (SUCRA=90.9 %). Egger’s test confirmed the robustness of this research.</div></div><div><h3>Conclusions</h3><div>DMT combined with CDE demonstrated the highest efficacy in improving depression, highlighting the importance of incorporating regional culture into dance therapy. DMT combined with drugs showed the most substantial improvements in anxiety and self-efficacy, reinforcing the recommendation that patients should keep pharmacological treatment. Drawing therapy combined with dance intervention and drugs had the most significant impact on quality of life, suggesting that patients should be encouraged to do more activities. DMT combined with psychological intervention and drugs was the most effective for positive coping. This indicates that psychological counseling is also important. To address multifaceted challenges, targeted intervention should be developed to meet diverse and complex needs comprehensively for patients.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103253"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-09-16DOI: 10.1016/j.ctim.2025.103246
Ann Linda Baldwin , Vicky McLelland , Duncan Cross , Nicole Braveman
Objective
Meditation and spirituality can enhance the well-being of allopathic healthcare providers and the quality of care they deliver but little is known about holistic healers, such as Reiki practitioners. Two surveys were developed to ascertain whether Reiki practitioners routinely use meditative and spiritual disciplines to strengthen their practice.
Method
The surveys were promoted through email using Mailchimp and Facebook to all members of UK Reiki Federation (about 1800) and through several other Facebook groups with a global reach. An online survey tool, SurveyMonkey, was used to collect the survey data and MS Excel to analyze it.
Results
Most respondents were white, heterosexual females, middle aged or older, residing in the UK or USA, trained to Reiki Master level. Over one third were Christian and another third affiliated with various non-established beliefs. Most participants experienced a spiritual connection when they practiced Reiki, which opened them to a higher power, and they thought this connection enhanced their self-development. Seventy-nine percent believed that Reiki spirit guides provide personal guidance, support, and assistance. Ninety-five percent meditated weekly from one to seven times a week and most believed that meditation increased their connection and ability to channel, Reiki.
Conclusion
Most respondents to the surveys routinely use meditation and spiritual connection to strengthen their Reiki practice and enhance their ability to channel Reiki to patients or clients. This information may stimulate inclusion of meditation and spirituality in the training of holistic healthcare professionals and help them communicate more effectively with their clients.
{"title":"How important are meditation and spirituality in Reiki practice?","authors":"Ann Linda Baldwin , Vicky McLelland , Duncan Cross , Nicole Braveman","doi":"10.1016/j.ctim.2025.103246","DOIUrl":"10.1016/j.ctim.2025.103246","url":null,"abstract":"<div><h3>Objective</h3><div>Meditation and spirituality can enhance the well-being of allopathic healthcare providers and the quality of care they deliver but little is known about holistic healers, such as Reiki practitioners. Two surveys were developed to ascertain whether Reiki practitioners routinely use meditative and spiritual disciplines to strengthen their practice.</div></div><div><h3>Method</h3><div>The surveys were promoted through email using Mailchimp and Facebook to all members of UK Reiki Federation (about 1800) and through several other Facebook groups with a global reach. An online survey tool, SurveyMonkey, was used to collect the survey data and MS Excel to analyze it.</div></div><div><h3>Results</h3><div>Most respondents were white, heterosexual females, middle aged or older, residing in the UK or USA, trained to Reiki Master level. Over one third were Christian and another third affiliated with various non-established beliefs. Most participants experienced a spiritual connection when they practiced Reiki, which opened them to a higher power, and they thought this connection enhanced their self-development. Seventy-nine percent believed that Reiki spirit guides provide personal guidance, support, and assistance. Ninety-five percent meditated weekly from one to seven times a week and most believed that meditation increased their connection and ability to channel, Reiki.</div></div><div><h3>Conclusion</h3><div>Most respondents to the surveys routinely use meditation and spiritual connection to strengthen their Reiki practice and enhance their ability to channel Reiki to patients or clients. This information may stimulate inclusion of meditation and spirituality in the training of holistic healthcare professionals and help them communicate more effectively with their clients.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103246"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-10-13DOI: 10.1016/j.ctim.2025.103262
Jing Xu , Runqing Lin , Aijia Zhang , Qiang Chen , Dexin Li , Jiajie Chen , Minglu Song , Shumei Chen , Bingjiao Yang , Linyang Li , Haotian Xu , Jinlin Peng , Yanrong Tang , Wenhua Yang , Xuexing Luo , Xiang Zhou , Jue Wang , Guanghui Huang
Objective
This randomized controlled trial evaluated the efficacy of AI-assisted drawing therapy for children with ADHD, comparing its impact on core symptoms and functional impairments against traditional drawing interventions while assessing engagement and the rapeuticoutcomes.
Methods
Forty-one children (ages 7–10) with ADHD were randomized into AI-assisted (n = 19) or traditional drawing therapy (n = 22) groups (Trial registered in ChiCTR: ChiCTR2400089640). The AI intervention employed a process that captured children's drawings, converted them into keywords, generated AI responses based on those keywords, and provided feedback to the children, while the control group received therapist-guided verbal feedback. SNAP-IV-26(Swanson, Nolan and Pelham-IV rating scales) and WFIRS-P(Weiss Functional Impairment Rating Scales-Parent) scales assessed at baseline (T1) and post-intervention (T2) at a 24-week interval, with data analyzed using independent t-tests (p < 0.05).
Results
Both AI-assisted and traditional drawing therapies significantly reduced core ADHD symptoms. In the before-and-after comparison within the group, the AI group showed targeted improvements in attention (p = 0.039) and oppositional defiant behaviour (p = 0.025), while traditional therapy produced broader symptom reductions across all domains (p < 0.05). Between-group comparisons showed that the AI-assisted group achieved greater improvement in inattention (Δ = −1.09, p = 0.035), whereas the traditional drawing group improved more on oppositional defiant behavior (Δ=+1.706, p = 0.010) and the SNAP-IV total score (Δ=+4.777, p = 0.041). On the WFIRS-P, the AI group showed advantages for the Family domain (p = 0.041) and the total score (p = 0.047), while Self-Concept favored the traditional drawing group (p = 0.036).
Conclusion
AI-assisted, drawing-based art therapy produced greater improvement in the pre-specified primary outcome (SNAP-IV inattention) and select WFIRS-P domains (e.g., Family, total score), whereas conventional drawing therapy yielded broader reductions in oppositional defiant symptoms and the overall SNAP-IV severity. Effects were modest and domain-specific; larger, multi-center trials are needed to confirm efficacy and identify which children benefit most.
{"title":"AI-assisted drawing therapy for children with ADHD: A randomised controlled trial","authors":"Jing Xu , Runqing Lin , Aijia Zhang , Qiang Chen , Dexin Li , Jiajie Chen , Minglu Song , Shumei Chen , Bingjiao Yang , Linyang Li , Haotian Xu , Jinlin Peng , Yanrong Tang , Wenhua Yang , Xuexing Luo , Xiang Zhou , Jue Wang , Guanghui Huang","doi":"10.1016/j.ctim.2025.103262","DOIUrl":"10.1016/j.ctim.2025.103262","url":null,"abstract":"<div><h3>Objective</h3><div>This randomized controlled trial evaluated the efficacy of AI-assisted drawing therapy for children with ADHD, comparing its impact on core symptoms and functional impairments against traditional drawing interventions while assessing engagement and the rapeuticoutcomes.</div></div><div><h3>Methods</h3><div>Forty-one children (ages 7–10) with ADHD were randomized into AI-assisted (n = 19) or traditional drawing therapy (n = 22) groups (Trial registered in ChiCTR: ChiCTR2400089640). The AI intervention employed a process that captured children's drawings, converted them into keywords, generated AI responses based on those keywords, and provided feedback to the children, while the control group received therapist-guided verbal feedback. SNAP-IV-26(Swanson, Nolan and Pelham-IV rating scales) and WFIRS-P(Weiss Functional Impairment Rating Scales-Parent) scales assessed at baseline (T1) and post-intervention (T2) at a 24-week interval, with data analyzed using independent t-tests (p < 0.05).</div></div><div><h3>Results</h3><div>Both AI-assisted and traditional drawing therapies significantly reduced core ADHD symptoms. In the before-and-after comparison within the group, the AI group showed targeted improvements in attention (p = 0.039) and oppositional defiant behaviour (p = 0.025), while traditional therapy produced broader symptom reductions across all domains (p < 0.05). Between-group comparisons showed that the AI-assisted group achieved greater improvement in inattention (Δ = −1.09, p = 0.035), whereas the traditional drawing group improved more on oppositional defiant behavior (Δ=+1.706, p = 0.010) and the SNAP-IV total score (Δ=+4.777, p = 0.041). On the WFIRS-P, the AI group showed advantages for the Family domain (p = 0.041) and the total score (p = 0.047), while Self-Concept favored the traditional drawing group (p = 0.036).</div></div><div><h3>Conclusion</h3><div>AI-assisted, drawing-based art therapy produced greater improvement in the pre-specified primary outcome (SNAP-IV inattention) and select WFIRS-P domains (e.g., Family, total score), whereas conventional drawing therapy yielded broader reductions in oppositional defiant symptoms and the overall SNAP-IV severity. Effects were modest and domain-specific; larger, multi-center trials are needed to confirm efficacy and identify which children benefit most.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103262"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-09-21DOI: 10.1016/j.ctim.2025.103248
Zhe-Kai Ying, Tian-Chen Lin, Jian-Nong Wu
{"title":"Letter to the editor regarding “Effects of intermittent fasting diet in overweight and obese postmenopausal women with rheumatoid arthritis: A randomized controlled clinical trial” by Ranjbar et al.","authors":"Zhe-Kai Ying, Tian-Chen Lin, Jian-Nong Wu","doi":"10.1016/j.ctim.2025.103248","DOIUrl":"10.1016/j.ctim.2025.103248","url":null,"abstract":"","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103248"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-09-21DOI: 10.1016/j.ctim.2025.103247
Cui Ye , Xuan Huang , Ziyu Wang , Shufang Zuo , Lu Lin
Objectives
To evaluate the effects of aromatherapy on sleep quality in hospitalized cardiac patients, taking into account factors such as participant age, type of essential oil, dosage, treatment duration, and daily frequency of use.
Methods
A systematic search and screening of literature on the effects of aromatherapy on sleep quality in hospitalized cardiac patients, published as randomized controlled trials (RCTs) in Chinese and English from inception to 8 August, 2025, was conducted across eight databases, including PubMed, Web of Science, Embase, Cochrane Library, CNKI, CBM, VIP, and Wanfang. The methodological quality of the included studies was independently and critically assessed by two reviewers using the Cochrane Risk of Bias Assessment Tool for RCTs. Relevant data were extracted using pre-designed forms and analyzed with STATA 17.0.
Results
A total of nine studies comprising 13 trials with 740 hospitalized cardiac patients were included. The results indicated that aromatherapy with single essential oils was moderately effective in improving sleep quality in these patients [SMD = -0.74, 95 % CI (-1.06, − 0.42), p = 0.003]. Subgroup analyses revealed significant improvements when patients were aged ≥ 60 years [SMD = -1.08, 95 %CI (-1.91,-0.24), P = 0.012], when Rosa damascena essential oil was used [SMD = -1.43, 95 %CI (-2.73,-0.13), P = 0.031], when the dosage was > 3 drops [SMD = -1.10, 95 %CI (-1.87,-0.32), P = 0.005], or when the treatment duration was ≥ 3 days [SMD = -0.99, 95 %CI (-1.59,-0.38), P = 0.001]. No adverse events were reported.
Conclusion
This study reveals that single essential oils are effective in improving sleep quality in hospitalized cardiac patients and can be recommended as a complementary therapy to improve sleep quality in this population.
{"title":"Effects of aromatherapy on sleep quality in hospitalized cardiac patients: A systematic review and meta-analysis of randomized controlled trials","authors":"Cui Ye , Xuan Huang , Ziyu Wang , Shufang Zuo , Lu Lin","doi":"10.1016/j.ctim.2025.103247","DOIUrl":"10.1016/j.ctim.2025.103247","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the effects of aromatherapy on sleep quality in hospitalized cardiac patients, taking into account factors such as participant age, type of essential oil, dosage, treatment duration, and daily frequency of use.</div></div><div><h3>Methods</h3><div>A systematic search and screening of literature on the effects of aromatherapy on sleep quality in hospitalized cardiac patients, published as randomized controlled trials (RCTs) in Chinese and English from inception to 8 August, 2025, was conducted across eight databases, including PubMed, Web of Science, Embase, Cochrane Library, CNKI, CBM, VIP, and Wanfang. The methodological quality of the included studies was independently and critically assessed by two reviewers using the Cochrane Risk of Bias Assessment Tool for RCTs. Relevant data were extracted using pre-designed forms and analyzed with STATA 17.0.</div></div><div><h3>Results</h3><div>A total of nine studies comprising 13 trials with 740 hospitalized cardiac patients were included. The results indicated that aromatherapy with single essential oils was moderately effective in improving sleep quality in these patients [SMD = -0.74, 95 % CI (-1.06, − 0.42), <em>p</em> = 0.003]. Subgroup analyses revealed significant improvements when patients were aged ≥ 60 years [SMD = -1.08, 95 %CI (-1.91,-0.24), P = 0.012], when Rosa damascena essential oil was used [SMD = -1.43, 95 %CI (-2.73,-0.13), P = 0.031], when the dosage was > 3 drops [SMD = -1.10, 95 %CI (-1.87,-0.32), P = 0.005], or when the treatment duration was ≥ 3 days [SMD = -0.99, 95 %CI (-1.59,-0.38), P = 0.001]. No adverse events were reported.</div></div><div><h3>Conclusion</h3><div>This study reveals that single essential oils are effective in improving sleep quality in hospitalized cardiac patients and can be recommended as a complementary therapy to improve sleep quality in this population.</div></div><div><h3>Registration</h3><div>PROSPERO: CRD42024535895.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103247"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-10-01DOI: 10.1016/j.ctim.2025.103252
Xiaolin Wei , Dan Liu , Ruzhen Yuan , Wei Zheng , Kunpeng Li , Caiqin Wu
Background
Post-operative breast cancer patients undergoing chemotherapy frequently experience concurrent upper limb dysfunction and chemotherapy-related cognitive impairment, creating a synergistic burden that complicates rehabilitation. Existing interventions often target these issues in isolation. Baduanjin, a traditional Chinese mind-body exercise, integrates physical movement with cognitive engagement, making it a promising candidate for addressing both domains simultaneously. However, robust evidence from randomized controlled trials (RCTs) was lacking. This RCT aimed to evaluate the effects of Baduanjin on both cognitive performance and upper limb function in this population.
Methods
A two-arm, randomized controlled trial was conducted. Seventy women diagnosed with breast cancer and scheduled for chemotherapy were randomly assigned to either a 12-week supervised Baduanjin exercise group or a control group receiving usual care. Subjective cognitive function was assessed using the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog). The neuropsychological test battery included the Auditory Verbal Learning Test (AVLT), the Trail Making Test (TMT), and the Digit Symbol Substitution Test (DSST). Upper limb function was assessed using the Constant-Murley Score (CMS). All assessments were performed at baseline (T0), Week 4 (T1), Week 8 (T2), and Week 12 (T3).
Results
Compared to the control group, the Baduanjin group demonstrated significant improvements in total FACT-Cog scores (F=17.710, p < 0.001), perceived cognitive impairments (F=20.085, p < 0.001), and perceived cognitive abilities (F=5.116, p = 0.027). A statistically significant group effect was observed for AVLT6 (F=13.862, p < 0.001). In addition, significant differences were observed between the two groups in shoulder function (p = 0.004, 95 % CI: 1.09, 5.59) and ROM (p = 0.002, 95 % CI: 0.87, 3.98).
Conclusion
A 12-week Baduanjin exercise intervention significantly improved subjective cognitive complaints and shoulder function in breast cancer patients undergoing post-operative chemotherapy. The findings support Baduanjin as a safe, feasible, and beneficial adjunct therapy that can concurrently address two prevalent and distressing sequelae of breast cancer treatment.
背景：接受化疗的乳腺癌术后患者经常同时出现上肢功能障碍和化疗相关的认知障碍，造成了使康复复杂化的协同负担。现有的干预措施往往孤立地针对这些问题。八段锦是一种传统的中国身心运动，它将身体运动与认知参与结合起来，使其成为同时解决这两个领域的有希望的候选人。然而，缺乏随机对照试验（rct）的有力证据。本随机对照试验旨在评估八段锦对该人群认知能力和上肢功能的影响。方法：采用两组随机对照试验。70名确诊为乳腺癌并计划接受化疗的妇女被随机分配到一个为期12周的有监督的八段锦运动组和一个接受常规护理的对照组。主观认知功能评估采用癌症治疗-认知功能功能评估（FACT-Cog）。神经心理测试组包括听觉语言学习测试（AVLT）、痕迹制造测试（TMT）和数字符号替代测试（DSST）。采用Constant-Murley评分（CMS）评估上肢功能。所有评估均在基线（T0）、第4周（T1）、第8周（T2）和第12周（T3）进行。结果：与对照组相比，八段锦组在FACT-Cog总分（F=17.710, p < 0.001）、认知障碍感知（F=20.085, p < 0.001）和认知能力感知（F=5.116, p=0.027）方面均有显著改善。AVLT6的组效应有统计学意义（F=13.862, p < 0.001）。此外，两组肩关节功能（p=0.004, 95% CI: 1.09, 5.59）和关节活动度（p=0.002, 95% CI: 0.87, 3.98）也有显著差异。结论：为期12周的八段锦运动干预可显著改善乳腺癌术后化疗患者的主观认知主诉和肩部功能。研究结果支持八段锦作为一种安全、可行、有益的辅助疗法，可以同时解决乳腺癌治疗中两种普遍存在的令人痛苦的后遗症。
{"title":"Effects of Baduanjin on cognitive performance and upper limb function in patients receiving chemotherapy after breast cancer surgery: A randomized controlled trial","authors":"Xiaolin Wei , Dan Liu , Ruzhen Yuan , Wei Zheng , Kunpeng Li , Caiqin Wu","doi":"10.1016/j.ctim.2025.103252","DOIUrl":"10.1016/j.ctim.2025.103252","url":null,"abstract":"<div><h3>Background</h3><div>Post-operative breast cancer patients undergoing chemotherapy frequently experience concurrent upper limb dysfunction and chemotherapy-related cognitive impairment, creating a synergistic burden that complicates rehabilitation. Existing interventions often target these issues in isolation. Baduanjin, a traditional Chinese mind-body exercise, integrates physical movement with cognitive engagement, making it a promising candidate for addressing both domains simultaneously. However, robust evidence from randomized controlled trials (RCTs) was lacking. This RCT aimed to evaluate the effects of Baduanjin on both cognitive performance and upper limb function in this population.</div></div><div><h3>Methods</h3><div>A two-arm, randomized controlled trial was conducted. Seventy women diagnosed with breast cancer and scheduled for chemotherapy were randomly assigned to either a 12-week supervised Baduanjin exercise group or a control group receiving usual care. Subjective cognitive function was assessed using the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog). The neuropsychological test battery included the Auditory Verbal Learning Test (AVLT), the Trail Making Test (TMT), and the Digit Symbol Substitution Test (DSST). Upper limb function was assessed using the Constant-Murley Score (CMS). All assessments were performed at baseline (T0), Week 4 (T1), Week 8 (T2), and Week 12 (T3).</div></div><div><h3>Results</h3><div>Compared to the control group, the Baduanjin group demonstrated significant improvements in total FACT-Cog scores (<em>F</em>=17.710, <em>p</em> < 0.001), perceived cognitive impairments (<em>F</em>=20.085, <em>p</em> < 0.001), and perceived cognitive abilities (<em>F</em>=5.116, <em>p</em> = 0.027). A statistically significant group effect was observed for AVLT6 (<em>F</em>=13.862, <em>p</em> < 0.001). In addition, significant differences were observed between the two groups in shoulder function (<em>p</em> = 0.004, 95 % CI: 1.09, 5.59) and ROM (<em>p</em> = 0.002, 95 % CI: 0.87, 3.98).</div></div><div><h3>Conclusion</h3><div>A 12-week Baduanjin exercise intervention significantly improved subjective cognitive complaints and shoulder function in breast cancer patients undergoing post-operative chemotherapy. The findings support Baduanjin as a safe, feasible, and beneficial adjunct therapy that can concurrently address two prevalent and distressing sequelae of breast cancer treatment.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103252"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-09-13DOI: 10.1016/j.ctim.2025.103242
Hamidreza Shiri , Ali Akbar Soleimani , Behnam Omidi Sarajar , Abdolkarim Talebi Taheri , Fataneh Esmaeili , Mohammad Hadi Nematollahi , Mahmood Alizadeh Sani
Introduction
CVDs are considered the major public health concern and mortality in the world. Common treatments have some side effects and require low-risk treatments, such as herbal medicine. Spirulina is a filamentous microalga that has improved cardiometabolic parameters.
Methods
Systematic searches were conducted in Scopus, ISI Web of Science, and PubMed/Medline databases up to 20 January 2025 to identify RCTs based on the PRISMA checklist and PICOS criteria (People > 18 years, Intervention: spirulina, Comparison: placebo /control, Outcomes: TG, TC, LDL-C, HDL-C, FBG, HbA1c, insulin, HOMA-IR, SBP, DBP, BMI, weight, hs-CRP, IL-6, TNF-α, and Study: RCTs). Meta- analysis was utilized by random-effects models, and the GRADE criteria ensured the certainty of results.
Result
The results of 35 trials (45 effect sizes) show that spirulina intake improved glucose homeostasis (FBG; WMD: −5.51 (mg/dl); P = 0.001, HOMA-IR; WMD: −0.68; P < 0.001, and insulin; WMD: −0.86 (ng/ml); P = 0.002), decreased dyslipidemia (TG; WMD: −14.75 (mg/dl); P < 0.001, TC: WMD: −11.5 (mg/dl); P < 0.001, LDL-C; WMD: −7.69 (mg/dl); P < 0.001, and HDL-C; WMD: 1.9 (mg/dl); P < 0.001), decreased blood pressure (SBP; WMD: −3.85 mmHg, P = 0.002, and DBP; WMD: −3.09 mmHg, P < 0.001), reduced anthropometric indexes (weight; WMD: −1.78 kg; P = 0.003, and BMI; WMD: −0.58 kg/m²; P = 0.001), and decreased inflammation (TNF-α; WMD: −0.46 pg/ml; P = 0.01, IL-6; WMD: −0.58 pg/ml; P < 0.001, and hs-CRP; WMD: −0.86 mg/L; P = 0.002). Based on GRADE analysis, LDL-C, FBG, and HbA1c had of low quality, while the outcome for weight was of high quality. Furthermore, other parameters had moderate-quality outcomes.
Conclusion
This study demonstrates that spirulina supplementation effectively reduces the risk of CVD in adults by improving glucose homeostasis, dyslipidemia, blood pressure, anthropometric indexes, and inflammation. So, intake of spirulina is an adjunct or complementary to improve cardiometabolic profiles.
Trial registration
PROSPERO registration cod: (CRD42024626090)
心血管疾病被认为是世界上主要的公共卫生问题和死亡率。普通的治疗方法有一些副作用，需要低风险的治疗，比如草药。螺旋藻是一种丝状微藻，具有改善心脏代谢参数的作用。方法系统检索Scopus、ISI Web of Science和PubMed/Medline数据库，截至2025年1月20日，根据PRISMA检查表和PICOS标准（患者18岁，干预：螺旋藻，比较：安慰剂/对照，结局：TG、TC、LDL-C、HDL-C、FBG、HbA1c、胰岛素、HOMA-IR、收缩压、舒压、BMI、体重、hs-CRP、IL-6、TNF-α和研究：rct）确定rct。随机效应模型采用Meta分析，GRADE标准保证了结果的确定性。结果35项试验（45个效应量）的结果表明，螺旋藻摄入改善了葡萄糖稳态(FBG; WMD: - 5.51 (mg/dl)；0.001 P = HOMA-IR;大规模杀伤性武器:−0.68;P <； 0.001，胰岛素；WMD:−0.86 (ng/ml)；P = 0.002)，降低血脂异常(TG; WMD:−14.75 (mg/dl)；P <； 0.001,TC: WMD: - 11.5 (mg/dl)；P & lt; 0.001,低密度;WMD:−7.69 (mg/dl)；P <； 0.001,HDL-C；WMD: 1.9 (mg/dl)；P & lt; 0.001),降低血压(SBP;大规模杀伤性武器:−3.85 mmHg, P = 0.002,和菲律宾;大规模杀伤性武器:−3.09 mmHg, P & lt; 0.001),降低人体测量指标(体重;大规模杀伤性武器:− 公斤1.78;P = 0.003,体重指数;大规模杀伤性武器:−0.58 公斤/ m²;P = 0.001),并降低炎症(TNF -α;大规模杀伤性武器:−0.46 pg / ml; P = 0.01,il - 6,大规模杀伤性武器:−0.58 pg / ml; P & lt; 0.001,和hs-CRP;大规模杀伤性武器:−0.86 mg / L; P = 0.002)。根据GRADE分析，LDL-C、FBG和HbA1c的结果质量较低，而体重的结果质量较高。此外，其他参数具有中等质量的结果。结论本研究表明，螺旋藻补充可通过改善葡萄糖稳态、血脂异常、血压、人体测量指标和炎症，有效降低成人心血管疾病的风险。因此，螺旋藻的摄入是一种辅助或补充，以改善心脏代谢谱。试用注册普洛斯佩罗注册编号：（CRD42024626090）
{"title":"Spirulina’s impacts on cardiovascular health: Insights from a systematic meta-analysis of RCT","authors":"Hamidreza Shiri , Ali Akbar Soleimani , Behnam Omidi Sarajar , Abdolkarim Talebi Taheri , Fataneh Esmaeili , Mohammad Hadi Nematollahi , Mahmood Alizadeh Sani","doi":"10.1016/j.ctim.2025.103242","DOIUrl":"10.1016/j.ctim.2025.103242","url":null,"abstract":"<div><h3>Introduction</h3><div>CVDs are considered the major public health concern and mortality in the world. Common treatments have some side effects and require low-risk treatments, such as herbal medicine. Spirulina is a filamentous microalga that has improved cardiometabolic parameters.</div></div><div><h3>Methods</h3><div>Systematic searches were conducted in Scopus, ISI Web of Science, and PubMed/Medline databases up to 20 January 2025 to identify RCTs based on the PRISMA checklist and PICOS criteria (People > 18 years, Intervention: spirulina, Comparison: placebo /control, Outcomes: TG, TC, LDL-C, HDL-C, FBG, HbA1c, insulin, HOMA-IR, SBP, DBP, BMI, weight, hs-CRP, IL-6, TNF-α, and Study: RCTs). Meta- analysis was utilized by random-effects models, and the GRADE criteria ensured the certainty of results.</div></div><div><h3>Result</h3><div>The results of 35 trials (45 effect sizes) show that spirulina intake improved glucose homeostasis (FBG; WMD: −5.51 (mg/dl); <em>P</em> = 0.001, HOMA-IR; WMD: −0.68; <em>P</em> < 0.001, and insulin; WMD: −0.86 (ng/ml); <em>P</em> = 0.002), decreased dyslipidemia (TG; WMD: −14.75 (mg/dl); <em>P</em> < 0.001, TC: WMD: −11.5 (mg/dl); <em>P</em> < 0.001, LDL-C; WMD: −7.69 (mg/dl); <em>P</em> < 0.001, and HDL-C; WMD: 1.9 (mg/dl); <em>P</em> < 0.001), decreased blood pressure (SBP; WMD: −3.85 mmHg, <em>P</em> = 0.002, and DBP; WMD: −3.09 mmHg, <em>P</em> < 0.001), reduced anthropometric indexes (weight; WMD: −1.78 kg; <em>P</em> = 0.003, and BMI; WMD: −0.58 kg/m²; <em>P</em> = 0.001), and decreased inflammation (TNF-α; WMD: −0.46 pg/ml; <em>P</em> = 0.01, IL-6; WMD: −0.58 pg/ml; <em>P</em> < 0.001, and hs-CRP; WMD: −0.86 mg/L; <em>P</em> = 0.002). Based on GRADE analysis, LDL-C, FBG, and HbA1c had of low quality, while the outcome for weight was of high quality. Furthermore, other parameters had moderate-quality outcomes.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that spirulina supplementation effectively reduces the risk of CVD in adults by improving glucose homeostasis, dyslipidemia, blood pressure, anthropometric indexes, and inflammation. So, intake of spirulina is an adjunct or complementary to improve cardiometabolic profiles.</div></div><div><h3>Trial registration</h3><div>PROSPERO registration cod: (CRD42024626090)</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103242"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-10-14DOI: 10.1016/j.ctim.2025.103261
Ling Men , Ling-Ling Liang , Shang-Wei Wu , Yi Sun , Hao Liu , Qiang Mi , Maryam Mazhar , Gang Luo , Qiu-Yu Liu , Meng-Nan Liu
Objective
This narrative review comprehensively explores the physiological mechanisms, psychological effects, and theoretical hypotheses of aromatherapy, along with its applications in clinical practice.
Background
Aromatherapy, utilizing plant-derived essential oils, is a significant component of complementary medicine widely implemented in clinical practice. Recent research advancements demonstrate its regulatory effects physiologically and psychologically, showing clinical potential for nervous, circulatory, and immune systems.
Methods
Searches were conducted in the China National Knowledge Infrastructure (CNKI), PubMed, and Web of Science databases to identify relevant studies published in recent years. Based on the retrieved literature, the biological effects of aromatherapy on the nervous, circulatory, and immune systems are summarized in this review.
Discussion
From a physiological perspective, olfactory molecules can enter the bloodstream either through the olfactory system or via transdermal absorption, subsequently modulating the immune system. They have been shown to inhibit the release of pro-inflammatory cytokines, enhance the expression of anti-inflammatory factors, scavenge free radicals, reduce cellular oxidative stress, and mitigate systemic inflammatory responses. Regarding psychological effects, aromatherapy modulates the secretion of neurotransmitters such as gamma-aminobutyric acid (GABA), thereby alleviating anxiety. Additionally, it influences emotional states and cognitive functions by stimulating the olfactory system, which interacts with the limbic system and brain regions involved in emotional processing. Specific essential oils like lavender demonstrate substantial evidence for analgesic and anxiolytic effects, while Rosmarinus officinalis shows efficacy in enhancing cognitive function. The review particularly focuses on its mechanisms and clinical applications in pain relief, anti-inflammatory activity, antioxidative properties, antidepressant and anxiolytic effects, and adjunctive care.
Conclusion
Future research should prioritize elucidating mechanisms of action, bioavailability, and long-term safety to fully uncover its therapeutic potential.
目的：全面探讨芳香疗法的生理机制、心理效应、理论假设及其在临床中的应用。背景：芳香疗法，利用植物源性精油，是补充医学的一个重要组成部分，广泛应用于临床实践。最近的研究进展表明其在生理和心理上的调节作用，在神经系统、循环系统和免疫系统中显示出临床潜力。方法：检索中国知网（CNKI）、PubMed和Web of Science数据库，检索近年来发表的相关研究。本文在查阅文献的基础上，综述了芳香疗法对神经系统、循环系统和免疫系统的生物学效应。讨论：从生理学的角度来看，嗅觉分子可以通过嗅觉系统或经皮吸收进入血液，从而调节免疫系统。它们已被证明可以抑制促炎细胞因子的释放，增强抗炎因子的表达，清除自由基，减少细胞氧化应激，减轻全身炎症反应。在心理作用方面，芳香疗法可调节γ -氨基丁酸（GABA）等神经递质的分泌，从而缓解焦虑。此外，它通过刺激嗅觉系统来影响情绪状态和认知功能，嗅觉系统与边缘系统和参与情绪处理的大脑区域相互作用。特定的精油，如薰衣草，具有镇痛和抗焦虑作用，而迷迭香则具有增强认知功能的功效。综述了其在镇痛、抗炎、抗氧化、抗抑郁、抗焦虑、辅助治疗等方面的作用机制和临床应用。结论：未来的研究应优先阐明其作用机制、生物利用度和长期安全性，以充分挖掘其治疗潜力。
{"title":"A narrative review of aromatherapy: Mechanisms and clinical value in physiological and psychological regulation","authors":"Ling Men , Ling-Ling Liang , Shang-Wei Wu , Yi Sun , Hao Liu , Qiang Mi , Maryam Mazhar , Gang Luo , Qiu-Yu Liu , Meng-Nan Liu","doi":"10.1016/j.ctim.2025.103261","DOIUrl":"10.1016/j.ctim.2025.103261","url":null,"abstract":"<div><h3>Objective</h3><div>This narrative review comprehensively explores the physiological mechanisms, psychological effects, and theoretical hypotheses of aromatherapy, along with its applications in clinical practice.</div></div><div><h3>Background</h3><div>Aromatherapy, utilizing plant-derived essential oils, is a significant component of complementary medicine widely implemented in clinical practice. Recent research advancements demonstrate its regulatory effects physiologically and psychologically, showing clinical potential for nervous, circulatory, and immune systems.</div></div><div><h3>Methods</h3><div>Searches were conducted in the China National Knowledge Infrastructure (CNKI), PubMed, and Web of Science databases to identify relevant studies published in recent years. Based on the retrieved literature, the biological effects of aromatherapy on the nervous, circulatory, and immune systems are summarized in this review.</div></div><div><h3>Discussion</h3><div>From a physiological perspective, olfactory molecules can enter the bloodstream either through the olfactory system or via transdermal absorption, subsequently modulating the immune system. They have been shown to inhibit the release of pro-inflammatory cytokines, enhance the expression of anti-inflammatory factors, scavenge free radicals, reduce cellular oxidative stress, and mitigate systemic inflammatory responses. Regarding psychological effects, aromatherapy modulates the secretion of neurotransmitters such as gamma-aminobutyric acid (GABA), thereby alleviating anxiety. Additionally, it influences emotional states and cognitive functions by stimulating the olfactory system, which interacts with the limbic system and brain regions involved in emotional processing. Specific essential oils like lavender demonstrate substantial evidence for analgesic and anxiolytic effects, while Rosmarinus officinalis shows efficacy in enhancing cognitive function. The review particularly focuses on its mechanisms and clinical applications in pain relief, anti-inflammatory activity, antioxidative properties, antidepressant and anxiolytic effects, and adjunctive care.</div></div><div><h3>Conclusion</h3><div>Future research should prioritize elucidating mechanisms of action, bioavailability, and long-term safety to fully uncover its therapeutic potential.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103261"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Overweight and obesity are major health concerns. The impact of ginger on weight has been studied. In the present systematic review and dose-response meta-analysis we aim to sum up the findings from randomized controlled trials (RCTs) on the effect of ginger on various weight measurements/indices.
Methods
Several databases (PubMed, Scopus, Web of Science Core Collection, and Google Scholar) were comprehensively searched. Relevant studies were selected using defined criteria. Outcomes included: body weight (BW), body mass index (BMI), waist circumference (WC), body fat percentage (BFP), adiponectin and leptin. Weighted mean difference (WMD) and confidence interval (CI) were reported. Subgroup analysis was carried out. Linear and non-linear associations, based on dosage and duration of interventions, were investigated.
Results
Thirty-six RCTs were included. Ginger supplementation significantly improved WC (WMD: −0.65 cm, 95 % CI: −1.07, −0.24), BFP (WMD: −1.49 %, 95 % CI: −2.65, −0.32), and serum adiponectin levels (WMD = 0.84 μg/mL; 95 % CI: 0.01). Other measurements were not improved by the intervention. An inverse, linear association was found between the duration of intervention and changes in BW (BW: coefficient = -0.471, P = 0.001). Also, a non-linear direct association was observed between ginger dosages and WC (P-nonlinearity = 0.023).
Conclusions
Ginger supplementation does not seem effective in improving major measurements/indices of weight, including body weight and BMI. However, ameliorations in other measurements of local adiposity, findings from subgroup analyses, and investigations of linear and non-linear association on dosage and duration, indicate that further studies with longer intervention periods are needed to make a conclusive decision.
{"title":"Impact of ginger supplementation on obesity indices and Adipokine profiles in adults: A GRADE-based systematic review and dose-response meta-analysis of randomized controlled trials","authors":"Shrin Rjabi , Seyed Sina Seyedhatami , Maede Makhtoomi , Mohammad Reza Ahmadi , Saeede Alimohamadi , Ehsan Aliabadi , Soroush Talakesh , Mehran Nouri , Behzad Zamani , Moein Askarpour","doi":"10.1016/j.ctim.2025.103260","DOIUrl":"10.1016/j.ctim.2025.103260","url":null,"abstract":"<div><h3>Background</h3><div>Overweight and obesity are major health concerns. The impact of ginger on weight has been studied. In the present systematic review and dose-response meta-analysis we aim to sum up the findings from randomized controlled trials (RCTs) on the effect of ginger on various weight measurements/indices.</div></div><div><h3>Methods</h3><div>Several databases (PubMed, Scopus, Web of Science Core Collection, and Google Scholar) were comprehensively searched. Relevant studies were selected using defined criteria. Outcomes included: body weight (BW), body mass index (BMI), waist circumference (WC), body fat percentage (BFP), adiponectin and leptin. Weighted mean difference (WMD) and confidence interval (CI) were reported. Subgroup analysis was carried out. Linear and non-linear associations, based on dosage and duration of interventions, were investigated.</div></div><div><h3>Results</h3><div>Thirty-six RCTs were included. Ginger supplementation significantly improved WC (WMD: −0.65 cm, 95 % CI: −1.07, −0.24), BFP (WMD: −1.49 %, 95 % CI: −2.65, −0.32), and serum adiponectin levels (WMD = 0.84 μg/mL; 95 % CI: 0.01). Other measurements were not improved by the intervention. An inverse, linear association was found between the duration of intervention and changes in BW (BW: coefficient = -0.471, P = 0.001). Also, a non-linear direct association was observed between ginger dosages and WC (P-nonlinearity = 0.023).</div></div><div><h3>Conclusions</h3><div>Ginger supplementation does not seem effective in improving major measurements/indices of weight, including body weight and BMI. However, ameliorations in other measurements of local adiposity, findings from subgroup analyses, and investigations of linear and non-linear association on dosage and duration, indicate that further studies with longer intervention periods are needed to make a conclusive decision.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103260"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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