Pub Date : 2024-06-01DOI: 10.1016/j.ctim.2024.103057
Han-Gyul Lee , Hyein Jeong , Chan-Young Kwon , Kyeong-Han Kim , Soo Hyun Sung , Ji Eun Han , Minjung Park , Soobin Jang
Background
Herbal decoctions (HDs) are the oldest and most common herbal medicine formulations. Different HDs exist, and some consumers are concerned that they may become contaminated during manufacturing. Therefore, the need for a safety assessment of HDs has been raised. This study aimed to investigate the adverse events (AEs) associated with HDs by comprehensively analyzing randomized controlled trials (RCTs) using systematic reviews and meta-analyses.
Methods
A systematic search was conducted on PubMed, Embase, and the Cochrane Library for articles published up to November 2022. The included RCTs compared HDs with other treatments published between 2013 and 2022, and the risk of bias was assessed using RevMan 5.4. Meta-analyses of the number of AEs associated with HDs reported in the included RCTs were also performed.
Results
The systematic review included 26 RCTs, and the meta-analysis included 17 RCTs that reported AEs. The meta-analysis comparing HDs with active controls showed that both the number of AEs (14 studies; risk ratio (RR)= 0.50 cases, 95 % confidence interval (CI) [0.29, 0.88]; I2 = 42 %) and the number of patients who complained of AEs (seven studies; RR=0.51 patients, 95 % CI [0.28, 0.94]; I2 =9 %) were fewer in the HDs group than in the active control groups.
Conclusion
This study showed that HDs are safer than other conventional medications based on the results of qualitative and quantitative syntheses of RCTs.
{"title":"Adverse events of herbal decoction: A systematic review and meta-analysis over past 10 years","authors":"Han-Gyul Lee , Hyein Jeong , Chan-Young Kwon , Kyeong-Han Kim , Soo Hyun Sung , Ji Eun Han , Minjung Park , Soobin Jang","doi":"10.1016/j.ctim.2024.103057","DOIUrl":"10.1016/j.ctim.2024.103057","url":null,"abstract":"<div><h3>Background</h3><p>Herbal decoctions (HDs) are the oldest and most common herbal medicine formulations. Different HDs exist, and some consumers are concerned that they may become contaminated during manufacturing. Therefore, the need for a safety assessment of HDs has been raised. This study aimed to investigate the adverse events (AEs) associated with HDs by comprehensively analyzing randomized controlled trials (RCTs) using systematic reviews and meta-analyses.</p></div><div><h3>Methods</h3><p>A systematic search was conducted on PubMed, Embase, and the Cochrane Library for articles published up to November 2022. The included RCTs compared HDs with other treatments published between 2013 and 2022, and the risk of bias was assessed using RevMan 5.4. Meta-analyses of the number of AEs associated with HDs reported in the included RCTs were also performed.</p></div><div><h3>Results</h3><p>The systematic review included 26 RCTs, and the meta-analysis included 17 RCTs that reported AEs. The meta-analysis comparing HDs with active controls showed that both the number of AEs (14 studies; risk ratio (RR)= 0.50 cases, 95 % confidence interval (CI) [0.29, 0.88]; I<sup>2</sup> = 42 %) and the number of patients who complained of AEs (seven studies; RR=0.51 patients, 95 % CI [0.28, 0.94]; I<sup>2</sup> =9 %) were fewer in the HDs group than in the active control groups.</p></div><div><h3>Conclusion</h3><p>This study showed that HDs are safer than other conventional medications based on the results of qualitative and quantitative syntheses of RCTs.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"83 ","pages":"Article 103057"},"PeriodicalIF":3.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000451/pdfft?md5=4ff6fcc836b26edc81e32a5a7a6954a0&pid=1-s2.0-S0965229924000451-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.ctim.2024.103058
Natalia Shania Francis , Yang Mooi Lim , Sumaiyah Mat , Annaletchumy Loganathan
Purpose
Hypertension is the primary cause of mortality. Hence globally, there is a growing interest in complementing antihypertensive drugs with herbs to alleviate blood pressure among hypertensive patients. Thus, this review aimed to evaluate the effectiveness of complementing drugs with herbs on blood pressure and lipid profile outcomes, the associated factors and the types of complementary herbs alongside their consumption regimes.
Methods
This review is registered in PROSPERO on the National Institute of Health Database with an ID: CRD42021270481. Using the PICOS (population, intervention, comparison, outcome, study type) mnemonic formula and search strategy, we searched (January 2010 to February 2024) five electronic databases including Pubmed, Scopus, Web of Science, CINAHL (Cumulative Index for Nursing and Allied Health Literature) and Psychology & Behavioral Sciences Collection (PBSC). The inclusion criteria of the review were that all included papers had to be randomised control trials in English among hypertensive adults who complemented antihypertensive drugs with herbs. A Cochrane risk of bias assessment as well as a meta-analysis and narrative synthesis were conducted to answer the objectives.
Results
Twenty-five randomised controlled trials involving 1996 participants from 14 countries were included. The risk of bias among included articles was assessed and presented using the Cochrane risk of bias tool and the graphs were generated. The effects of complementing antihypertensive drugs with different herb regimes on blood pressure and lipid profile outcomes were compared to those solely on antihypertensive drugs and placebo via a random model effects meta-analysis using the Revman manager. Systolic blood pressure (SBP) and triglycerides gave a significant reduction in favour of the intervention group which complemented herbs. The overall pooled systolic blood pressure showed a reduction of (SMD=0.81, 95 % CI 0.14–1.47, p < 0.02, p for heterogeneity=0.00001, I2 =97 %) while triglycerides were (SMD=0.73, 95 % CI 0.17–1.28, p < 0.01, p for heterogeneity=0.00001, I2 =85 %). However, diastolic blood pressure, total cholesterol, HDL and LDL did not exert significant outcomes.
Conclusion
The complemented herbs with antihypertensive drugs did show improvement in overall blood pressure management in the majority of the studies compared to the placebo group. Blood pressure and lipid profiles are the health outcomes that enable access to complementing herbs in controlling high blood pressure. Some limitations of this review are attributed to performance, detection and attrition bias in a few included articles alongside the presence of a high heterogeneity overall.
{"title":"Effectiveness of herbs taken concurrently with antihypertensive drugs in managing hypertension and lipid outcomes. A systematic review and meta-analysis.","authors":"Natalia Shania Francis , Yang Mooi Lim , Sumaiyah Mat , Annaletchumy Loganathan","doi":"10.1016/j.ctim.2024.103058","DOIUrl":"10.1016/j.ctim.2024.103058","url":null,"abstract":"<div><h3>Purpose</h3><p>Hypertension is the primary cause of mortality. Hence globally, there is a growing interest in complementing antihypertensive drugs with herbs to alleviate blood pressure among hypertensive patients. Thus, this review aimed to evaluate the effectiveness of complementing drugs with herbs on blood pressure and lipid profile outcomes, the associated factors and the types of complementary herbs alongside their consumption regimes.</p></div><div><h3>Methods</h3><p>This review is registered in PROSPERO on the National Institute of Health Database with an ID: CRD42021270481. Using the PICOS (population, intervention, comparison, outcome, study type) mnemonic formula and search strategy, we searched (January 2010 to February 2024) five electronic databases including Pubmed, Scopus, Web of Science, CINAHL (Cumulative Index for Nursing and Allied Health Literature) and Psychology & Behavioral Sciences Collection (PBSC). The inclusion criteria of the review were that all included papers had to be randomised control trials in English among hypertensive adults who complemented antihypertensive drugs with herbs. A Cochrane risk of bias assessment as well as a meta-analysis and narrative synthesis were conducted to answer the objectives.</p></div><div><h3>Results</h3><p>Twenty-five randomised controlled trials involving 1996 participants from 14 countries were included. The risk of bias among included articles was assessed and presented using the Cochrane risk of bias tool and the graphs were generated. The effects of complementing antihypertensive drugs with different herb regimes on blood pressure and lipid profile outcomes were compared to those solely on antihypertensive drugs and placebo via a random model effects meta-analysis using the Revman manager. Systolic blood pressure (SBP) and triglycerides gave a significant reduction in favour of the intervention group which complemented herbs. The overall pooled systolic blood pressure showed a reduction of (SMD=0.81, 95 % CI 0.14–1.47, <em>p</em> < 0.02, <em>p</em> for heterogeneity=0.00001, I<sup>2</sup> =97 %) while triglycerides were (SMD=0.73, 95 % CI 0.17–1.28, <em>p</em> < 0.01, <em>p</em> for heterogeneity=0.00001, I<sup>2</sup> =85 %). However, diastolic blood pressure, total cholesterol, HDL and LDL did not exert significant outcomes.</p></div><div><h3>Conclusion</h3><p>The complemented herbs with antihypertensive drugs did show improvement in overall blood pressure management in the majority of the studies compared to the placebo group. Blood pressure and lipid profiles are the health outcomes that enable access to complementing herbs in controlling high blood pressure. Some limitations of this review are attributed to performance, detection and attrition bias in a few included articles alongside the presence of a high heterogeneity overall.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"83 ","pages":"Article 103058"},"PeriodicalIF":3.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000463/pdfft?md5=f89493eb6b1f8cab1da8045ffd0270d6&pid=1-s2.0-S0965229924000463-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-29DOI: 10.1016/j.ctim.2024.103059
P.S. Deo , T.M. Barber , C. Gotts , M. Villarreal , H. Randeva , S. Brown , J. Bath , P. O’Hare , S. Chaggar , P. Hanson
Objective
The study aimed to investigate the feasibility of a remote mindfulness based self-management intervention for individuals with type 2 diabetes. It is important to further our understanding of how to improve self-management to improve health outcomes and low levels of uptake to self-management courses.
Method
29 participants with type 2 diabetes were recruited from the University Hospital Coventry and Warwickshire NHS trust. Three groups of participants engaged with a remote mindfulness based self-management intervention, which were delivered sequentially. After each intervention was complete, patient feedback was retrieved and implemented into the following intervention. The quantitative analysis comprised of descriptive statistics, independent sample t-test, paired sample t-test and multiple regression analysis. A qualitative analysis was also conducted through reflexive thematic analysis (RTA) to understand participant’s perspective on the intervention.
Results
There was a total of 17 who attended the course (59 %) and a total drop out of 12 participants over the three courses (41 %). The qualitative findings reported three main themes: (1) Eating to manage my emotions rather than my diabetes (2) Implementing mindfulness has helped me manage my emotions (3) Medication rather than self-management behaviours control my diabetes. The focus group feedback included participants’ appreciation of the community aspect of the intervention and their perception that the current course was more interactive compared to previous interventions. In addition, participants highlighted the importance of offering the course at an earlier stage of diagnosis to provide further support at the beginning of their diabetes journey. No significant findings were reported for the independent sample t-test, paired sample t-test and multiple regression analysis.
Conclusion
The qualitative findings suggested that the course was beneficial, especially in demonstrating how mindfulness could aid self-management for individuals living with type 2 diabetes. Further funding and trials are warranted to improve the quality of technology used and to assess impact on diabetes control and mental health.
研究目的该研究旨在调查对 2 型糖尿病患者进行远程正念自我管理干预的可行性。方法：从考文垂和沃里克郡大学医院 NHS 信托基金会招募了 29 名 2 型糖尿病患者。三组参与者依次接受了远程正念自我管理干预。每次干预结束后，都会收集患者的反馈意见，并将其应用到下一次干预中。定量分析包括描述性统计、独立样本 t 检验、配对样本 t 检验和多元回归分析。此外，还通过反思性主题分析（RTA）进行了定性分析，以了解参与者对干预措施的看法：共有 17 人参加了课程（占 59%），三门课程中共有 12 人退出（占 41%）。定性研究结果报告了三大主题：（1）饮食是为了控制情绪而不是控制糖尿病（2）正念的实施帮助我控制了情绪（3）药物治疗而不是自我管理行为控制了糖尿病。焦点小组的反馈意见包括，参与者对干预措施的社区性表示赞赏，并认为与以往的干预措施相比，目前的课程更具互动性。此外，参与者还强调了在确诊糖尿病的较早阶段提供该课程的重要性，以便在糖尿病初期提供进一步的支持。独立样本 t 检验、配对样本 t 检验和多元回归分析均未得出重要结果：定性研究结果表明，该课程是有益的，尤其是在展示正念如何帮助 2 型糖尿病患者进行自我管理方面。为提高所使用技术的质量并评估其对糖尿病控制和心理健康的影响，有必要进一步提供资金并开展试验。
{"title":"A pilot study to assess the feasibility and uptake of MindDEC, a mindfulness-based self-management course for type 2 diabetes","authors":"P.S. Deo , T.M. Barber , C. Gotts , M. Villarreal , H. Randeva , S. Brown , J. Bath , P. O’Hare , S. Chaggar , P. Hanson","doi":"10.1016/j.ctim.2024.103059","DOIUrl":"10.1016/j.ctim.2024.103059","url":null,"abstract":"<div><h3>Objective</h3><p>The study aimed to investigate the feasibility of a remote mindfulness based self-management intervention for individuals with type 2 diabetes. It is important to further our understanding of how to improve self-management to improve health outcomes and low levels of uptake to self-management courses.</p></div><div><h3>Method</h3><p>29 participants with type 2 diabetes were recruited from the University Hospital Coventry and Warwickshire NHS trust. Three groups of participants engaged with a remote mindfulness based self-management intervention, which were delivered sequentially. After each intervention was complete, patient feedback was retrieved and implemented into the following intervention. The quantitative analysis comprised of descriptive statistics, independent sample t-test, paired sample t-test and multiple regression analysis. A qualitative analysis was also conducted through reflexive thematic analysis (RTA) to understand participant’s perspective on the intervention.</p></div><div><h3>Results</h3><p>There was a total of 17 who attended the course (59 %) and a total drop out of 12 participants over the three courses (41 %). The qualitative findings reported three main themes: (1) Eating to manage my emotions rather than my diabetes (2) Implementing mindfulness has helped me manage my emotions (3) Medication rather than self-management behaviours control my diabetes. The focus group feedback included participants’ appreciation of the community aspect of the intervention and their perception that the current course was more interactive compared to previous interventions. In addition, participants highlighted the importance of offering the course at an earlier stage of diagnosis to provide further support at the beginning of their diabetes journey. No significant findings were reported for the independent sample t-test, paired sample t-test and multiple regression analysis.</p></div><div><h3>Conclusion</h3><p>The qualitative findings suggested that the course was beneficial, especially in demonstrating how mindfulness could aid self-management for individuals living with type 2 diabetes. Further funding and trials are warranted to improve the quality of technology used and to assess impact on diabetes control and mental health.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"83 ","pages":"Article 103059"},"PeriodicalIF":3.6,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000475/pdfft?md5=f69418341ed4e5d6fa7b65a80de54106&pid=1-s2.0-S0965229924000475-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-25DOI: 10.1016/j.ctim.2024.103053
Lili Yang , Xiaorui Liu , Wen Yang , Siqi Wang , Zimu Li , Yiming Lei , Dongling Liu
Objective
Shenmai injection is a classic herbal prescription, and is often recommended for the treatment of anthracycline-induced cardiotoxicity. However, the efficacy and safety of Shenmai injection for the treatment of anthracycline-induced cardiotoxicity have not been reported.
Materials and methods
We conducted a comprehensive search of eight literature databases and two clinical trial registries, retrieving all randomized controlled trials (RCTs) related to the treatment of anthracycline-induced cardiotoxicity with Shenmai injection from the establishment of the databases to July 1, 2023. Data analysis was performed using the Meta package in RStudio and RevMan 5.4. The GRADE pro3.6.1 software was utilized for assessing the quality of evidence.
Results
A total of 16 RCTs including 2140 patients were included in this study. Meta-analysis showed that Shenmai injection had an advantage in improving ST-T segment changes (RR = 0.28; 95 % CI, 0.20 to 0.39; P < 0.0001) (P < 0.01), creatine kinase isoenzyme (SMD = −3.49; 95 % CI, −5.24 to −1.74; P < 0.0001), Prolonged QT interval (RR = 0.46; 95 % CI, 0.28 to 0.75; P = 0.0018), Low QRS Voltage (RR = 0.44; 95 % CI, 0.27 to 0.71; P = 0.0007), sinus tachycardia (RR = 0.41; 95 % CI, 0.28 to 0.60; P < 0.0001), atrial premature beats (RR = 0.55; 95 % CI, 0.35 to 0.87; P = 0.01), Premature Ventricular Contractions (RR = 0.39; 95 % CI, 0.26 to 0.59; P < 0.0001) and creatine kinase (SMD = −1.43; 95 % CI, −2.57 to −0.29; P < 0.0001) in patients with anthracycline-induced cardiotoxicity. advantage, which was supported by sensitivity analyses, but not in improving left ventricular ejection fraction (MD = 16.01; 95 % CI, −3.10 to 35.12; P = 0.10) and atrioventricular block (RR = 0.49; 95 % CI, 0.24 to 1.03; P = 0.06). The literature included in the study did not refer to data regarding the safety aspects of Shenmai injection, so we do not yet know the safety of Shenmai injection. The results of subgroup analyses suggested that heterogeneity was not related to the administered dose and chemotherapy regimen. The publication bias test showed no publication bias. The quality of evidence for the results ranged from “very low” to “moderate.”
Conclusion
This study suggests that Shenmai injection is effective in treating anthracycline-induced cardiotoxicity and is a potential treatment for anthracycline-induced cardiotoxicity. However, due to the poor methodological quality of the included RCTs, we recommend rigorous, high-quality, large-sample trials to confirm our findings.
{"title":"Effect of shenmai injection on anthracycline-induced cardiotoxicity: A systematic review and meta-analysis","authors":"Lili Yang , Xiaorui Liu , Wen Yang , Siqi Wang , Zimu Li , Yiming Lei , Dongling Liu","doi":"10.1016/j.ctim.2024.103053","DOIUrl":"10.1016/j.ctim.2024.103053","url":null,"abstract":"<div><h3>Objective</h3><p>Shenmai injection is a classic herbal prescription, and is often recommended for the treatment of anthracycline-induced cardiotoxicity. However, the efficacy and safety of Shenmai injection for the treatment of anthracycline-induced cardiotoxicity have not been reported.</p></div><div><h3>Materials and methods</h3><p>We conducted a comprehensive search of eight literature databases and two clinical trial registries, retrieving all randomized controlled trials (RCTs) related to the treatment of anthracycline-induced cardiotoxicity with Shenmai injection from the establishment of the databases to July 1, 2023. Data analysis was performed using the Meta package in RStudio and RevMan 5.4. The GRADE pro3.6.1 software was utilized for assessing the quality of evidence.</p></div><div><h3>Results</h3><p>A total of 16 RCTs including 2140 patients were included in this study. Meta-analysis showed that Shenmai injection had an advantage in improving ST-T segment changes (RR = 0.28; 95 % CI, 0.20 to 0.39; <em>P</em> < 0.0001) (<em>P</em> < 0.01), creatine kinase isoenzyme (SMD = −3.49; 95 % CI, −5.24 to −1.74; <em>P</em> < 0.0001), Prolonged QT interval (RR = 0.46; 95 % CI, 0.28 to 0.75; <em>P</em> = 0.0018), Low QRS Voltage (RR = 0.44; 95 % CI, 0.27 to 0.71; <em>P</em> = 0.0007), sinus tachycardia (RR = 0.41; 95 % CI, 0.28 to 0.60; <em>P</em> < 0.0001), atrial premature beats (RR = 0.55; 95 % CI, 0.35 to 0.87; <em>P</em> = 0.01), Premature Ventricular Contractions (RR = 0.39; 95 % CI, 0.26 to 0.59; <em>P</em> < 0.0001) and creatine kinase (SMD = −1.43; 95 % CI, −2.57 to −0.29; <em>P</em> < 0.0001) in patients with anthracycline-induced cardiotoxicity. advantage, which was supported by sensitivity analyses, but not in improving left ventricular ejection fraction (MD = 16.01; 95 % CI, −3.10 to 35.12; <em>P</em> = 0.10) and atrioventricular block (RR = 0.49; 95 % CI, 0.24 to 1.03; <em>P</em> = 0.06). The literature included in the study did not refer to data regarding the safety aspects of Shenmai injection, so we do not yet know the safety of Shenmai injection. The results of subgroup analyses suggested that heterogeneity was not related to the administered dose and chemotherapy regimen. The publication bias test showed no publication bias. The quality of evidence for the results ranged from “very low” to “moderate.”</p></div><div><h3>Conclusion</h3><p>This study suggests that Shenmai injection is effective in treating anthracycline-induced cardiotoxicity and is a potential treatment for anthracycline-induced cardiotoxicity. However, due to the poor methodological quality of the included RCTs, we recommend rigorous, high-quality, large-sample trials to confirm our findings.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"83 ","pages":"Article 103053"},"PeriodicalIF":3.6,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000414/pdfft?md5=33a424fe527865aa08fc5af53ce617e3&pid=1-s2.0-S0965229924000414-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To determine the effects of traditional Thai massage (TTM) on improving fatigue recovery and fatigue-related parameters of the gastrocnemius muscle after a heel-raise exercise.
Design
A single-blind randomised controlled trial.
Setting
Mae Fah Luang University Hospital, Thailand.
Participants
Fifty-four healthy participants were randomly assigned to two groups: TTM (n = 27; 51.85 % women; mean age 23.15 ± 4.90 years; number of exercises/week: 4.78 ± 1.58) and control (n = 27; 59.26 % women; mean age 22.63 ± 4.88 years; number of exercises/week: 4.48 ± 1.25).
Interventions
After the participants performed a heel-raise exercise to induce fatigue of the gastrocnemius muscle, they received either 30 min of TTM to the gastrocnemius muscle or 30 min of control (29 min of rest and 1 min total gastrocnemius stretching).
Outcome measures
The outcome measures were the median frequency (MDF) of the electromyography signal, muscle power (MP) and feelings of muscle fatigue (FMF). All the outcome measures were evaluated before (T1) and after (T2) the fatigue-inducement protocol as well as immediately (T3), 1 h (T4) and 2 h (T5) after the interventions.
Results
The results show that MDF and MP were significantly increased and FMF significantly decreased in both groups immediately after the interventions and at 1 h and 2 h after the interventions (repeated measures ANOVA: p < .05). In the between-group comparisons, participants in the TTM group showed significantly greater improvement than those in the control group on all outcomes at all post-intervention assessment time points (T3, T4, T5), reflecting faster recovery from muscle fatigue (ANCOVA: p < .05).
Conclusion
TTM proved an effective intervention for maximising recovery from fatigue of the gastrocnemius muscle.
{"title":"The influence of traditional Thai massage on recovery from gastrocnemius muscle fatigue: A single-blind randomised controlled trial","authors":"Vitsarut Buttagat, Sujittra Kluayhomthong, Pattanasin Areeudomwong","doi":"10.1016/j.ctim.2024.103056","DOIUrl":"10.1016/j.ctim.2024.103056","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the effects of traditional Thai massage (TTM) on improving fatigue recovery and fatigue-related parameters of the gastrocnemius muscle after a heel-raise exercise.</p></div><div><h3>Design</h3><p>A single-blind randomised controlled trial.</p></div><div><h3>Setting</h3><p>Mae Fah Luang University Hospital, Thailand.</p></div><div><h3>Participants</h3><p>Fifty-four healthy participants were randomly assigned to two groups: TTM (n = 27; 51.85 % women; mean age 23.15 ± 4.90 years; number of exercises/week: 4.78 ± 1.58) and control (n = 27; 59.26 % women; mean age 22.63 ± 4.88 years; number of exercises/week: 4.48 ± 1.25).</p></div><div><h3>Interventions</h3><p>After the participants performed a heel-raise exercise to induce fatigue of the gastrocnemius muscle, they received either 30 min of TTM to the gastrocnemius muscle or 30 min of control (29 min of rest and 1 min total gastrocnemius stretching).</p></div><div><h3>Outcome measures</h3><p>The outcome measures were the median frequency (MDF) of the electromyography signal, muscle power (MP) and feelings of muscle fatigue (FMF). All the outcome measures were evaluated before (T1) and after (T2) the fatigue-inducement protocol as well as immediately (T3), 1 h (T4) and 2 h (T5) after the interventions.</p></div><div><h3>Results</h3><p>The results show that MDF and MP were significantly increased and FMF significantly decreased in both groups immediately after the interventions and at 1 h and 2 h after the interventions (repeated measures ANOVA: <em>p</em> < .05). In the between-group comparisons, participants in the TTM group showed significantly greater improvement than those in the control group on all outcomes at all post-intervention assessment time points (T3, T4, T5), reflecting faster recovery from muscle fatigue (ANCOVA: <em>p</em> < .05).</p></div><div><h3>Conclusion</h3><p>TTM proved an effective intervention for maximising recovery from fatigue of the gastrocnemius muscle.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"83 ","pages":"Article 103056"},"PeriodicalIF":3.6,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S096522992400044X/pdfft?md5=f4805386e5da6f487c24ecb26e2dfd83&pid=1-s2.0-S096522992400044X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-22DOI: 10.1016/j.ctim.2024.103054
Mohammad Abbasian Josheghani, Zahra Tagharrobi, Khadijeh Sharifi, Zahra Sooki, Fatemeh Zare Joshaghani, Mohammad Zare
Background
Given the high prevalence of depression in elderly people, appropriate interventions are essential. This study aimed to assess the effects of auriculotherapy on depression among elderly people.
Methods
This randomized controlled clinical trial was conducted in 2021. Fifty-two elderly were conveniently selected and randomly allocated to the sham (n = 26) and intervention (n = 26) groups through block randomization. The intervention group was subjected to four weeks of auriculotherapy at the Shen-Men, zero, heart, antidepressant, and master cerebral points using Vaccaria seeds fixed with adhesive tape. In the sham group, adhesive tapes were attached to the points with neither seeds nor compression. The elderly and data collector were blinded. The 15-item Geriatric Depression Scale was used to assess depression before, immediately after, and four weeks after the intervention (T1–T3). The statistical methods used were repeated measures analysis of variance and covariance.
Results
Groups significantly differed concerning participants' gender, education, and employment (p < 0.05). After adjusting for confounding effects, the time-group interaction significantly affected the mean depression score (p < 0.0001, effect size = 0.54). There was no significant difference between the depression score in the sham and intervention groups at T1 (9.6 ± 2.5 vs 9.5 ± 2.5, p = 0.263); however, this difference was found to be significant at T2 (8.6 ± 2 vs 4.2 ± 1.2, p < 0.0001, effect size = 0.68) and T3 (9.3 ± 2.3 vs 4.3 ± 1.3, p < 0.0001, effect size = 0.65). Within-group analysis revealed significant differences in the depression scores of the intervention group at T1 compared with those at T2 and T3 (p < 0.05). In contrast, the mean depression score in the sham group at T2 was significantly lower than that at T1 (p = 0.003) and greater than that at T3 (p = 0.049).
Conclusions
Auriculotherapy alleviates depression and can be used as a complementary therapy for elderly people with depression.
{"title":"The effects of auriculotherapy on depression among elderly people: A randomized controlled clinical trial","authors":"Mohammad Abbasian Josheghani, Zahra Tagharrobi, Khadijeh Sharifi, Zahra Sooki, Fatemeh Zare Joshaghani, Mohammad Zare","doi":"10.1016/j.ctim.2024.103054","DOIUrl":"10.1016/j.ctim.2024.103054","url":null,"abstract":"<div><h3>Background</h3><p>Given the high prevalence of depression in elderly people, appropriate interventions are essential. This study aimed to assess the effects of auriculotherapy on depression among elderly people.</p></div><div><h3>Methods</h3><p>This randomized controlled clinical trial was conducted in 2021. Fifty-two elderly were conveniently selected and randomly allocated to the sham (n = 26) and intervention (n = 26) groups through block randomization. The intervention group was subjected to four weeks of auriculotherapy at the Shen-Men, zero, heart, antidepressant, and master cerebral points using Vaccaria seeds fixed with adhesive tape. In the sham group, adhesive tapes were attached to the points with neither seeds nor compression. The elderly and data collector were blinded. The 15-item Geriatric Depression Scale was used to assess depression before, immediately after, and four weeks after the intervention (T1–T3). The statistical methods used were repeated measures analysis of variance and covariance.</p></div><div><h3>Results</h3><p>Groups significantly differed concerning participants' gender, education, and employment (p < 0.05). After adjusting for confounding effects, the time-group interaction significantly affected the mean depression score (p < 0.0001, effect size = 0.54). There was no significant difference between the depression score in the sham and intervention groups at T1 (9.6 ± 2.5 vs 9.5 ± 2.5, p = 0.263); however, this difference was found to be significant at T2 (8.6 ± 2 vs 4.2 ± 1.2, p < 0.0001, effect size = 0.68) and T3 (9.3 ± 2.3 vs 4.3 ± 1.3, p < 0.0001, effect size = 0.65). Within-group analysis revealed significant differences in the depression scores of the intervention group at T1 compared with those at T2 and T3 (p < 0.05). In contrast, the mean depression score in the sham group at T2 was significantly lower than that at T1 (p = 0.003) and greater than that at T3 (p = 0.049).</p></div><div><h3>Conclusions</h3><p>Auriculotherapy alleviates depression and can be used as a complementary therapy for elderly people with depression.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"83 ","pages":"Article 103054"},"PeriodicalIF":3.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000426/pdfft?md5=800eaccbafe39ed8d736d6cd18d7fc73&pid=1-s2.0-S0965229924000426-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-21DOI: 10.1016/j.ctim.2024.103055
Yuantao Hou , Hansheng Liang , Cungang Fan , Ruen Liu , Yi Feng
Background
Dizziness often occurs after microvascular decompression (MVD), and therapeutic options are limited. The aim of this trial was to determine the potential efficacy of transcutaneous electrical acupoint stimulation (TEAS), against dizziness and its safety in patients undergoing MVD.
Methods
Adult patients scheduled to undergo MVD for hemifacial spasm under total intravenous anesthesia were randomized at a 1:1 ratio to receive, after extubation, 30-min TEAS in the mastoid region as well as Fengchi acupoints (GB20) and Neiguan acupoints (PC6) or 30-min sham stimulation. The primary outcome was the incidence of dizziness at 2 h after surgery. Secondary outcomes included dizziness, postoperative nausea and vomiting (PONV) or headache severity, rescue medication, changes in intraocular pressure before and after surgery, length of stay, dizziness symptoms 4 weeks after discharge, and surgical complications.
Results
A total of 86 patients (51.9 ± 9.4 years of age; 67 women) were enrolled. One patient (in the TEAS arm) was excluded from analysis due to conversion to sevoflurane anesthesia. The rate of dizziness at 2 h after surgery was 31.0 % (13/42) in the TEAS arm vs. 53.5 % (23/43) in the sham control arm (P = 0.036). TEAS was also associated with significantly lower severity of dizziness, based on a 10-point scale, during the first 24 h after surgery. None of the other secondary efficacy outcomes differed significantly between the two arms. All postoperative complications were Clavien-Dindo grade I or II. The rate of postoperative complications was 21.4 % (9/42) in the TEAS arm vs. 16.3 % (7/43) in the sham control arm (P = 0.544).
Conclusions
Compared with sham control, TEAS was associated with a lower incidence of dizziness within 2 h and lower severity of dizziness within 24 h post-operatively, but no improvement in other outcomes, in adult patients undergoing MVD for hemifacial spasm.
{"title":"Transcutaneous electrical acupoint stimulation to prevent dizziness after microvascular decompression for hemifacial spasm: A randomized controlled trial","authors":"Yuantao Hou , Hansheng Liang , Cungang Fan , Ruen Liu , Yi Feng","doi":"10.1016/j.ctim.2024.103055","DOIUrl":"10.1016/j.ctim.2024.103055","url":null,"abstract":"<div><h3>Background</h3><p>Dizziness often occurs after microvascular decompression (MVD), and therapeutic options are limited. The aim of this trial was to determine the potential efficacy of transcutaneous electrical acupoint stimulation (TEAS), against dizziness and its safety in patients undergoing MVD.</p></div><div><h3>Methods</h3><p>Adult patients scheduled to undergo MVD for hemifacial spasm under total intravenous anesthesia were randomized at a 1:1 ratio to receive, after extubation, 30-min TEAS in the mastoid region as well as Fengchi acupoints (GB20) and Neiguan acupoints (PC6) or 30-min sham stimulation. The primary outcome was the incidence of dizziness at 2 h after surgery. Secondary outcomes included dizziness, postoperative nausea and vomiting (PONV) or headache severity, rescue medication, changes in intraocular pressure before and after surgery, length of stay, dizziness symptoms 4 weeks after discharge, and surgical complications.</p></div><div><h3>Results</h3><p>A total of 86 patients (51.9 ± 9.4 years of age; 67 women) were enrolled. One patient (in the TEAS arm) was excluded from analysis due to conversion to sevoflurane anesthesia. The rate of dizziness at 2 h after surgery was 31.0 % (13/42) in the TEAS arm <em>vs.</em> 53.5 % (23/43) in the sham control arm (<em>P</em> = 0.036). TEAS was also associated with significantly lower severity of dizziness, based on a 10-point scale, during the first 24 h after surgery. None of the other secondary efficacy outcomes differed significantly between the two arms. All postoperative complications were Clavien-Dindo grade I or II. The rate of postoperative complications was 21.4 % (9/42) in the TEAS arm <em>vs.</em> 16.3 % (7/43) in the sham control arm (<em>P</em> = 0.544).</p></div><div><h3>Conclusions</h3><p>Compared with sham control, TEAS was associated with a lower incidence of dizziness within 2 h and lower severity of dizziness within 24 h post-operatively, but no improvement in other outcomes, in adult patients undergoing MVD for hemifacial spasm.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"83 ","pages":"Article 103055"},"PeriodicalIF":3.6,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000438/pdfft?md5=cb473f096b37cf611f0111ba772a74f8&pid=1-s2.0-S0965229924000438-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-17DOI: 10.1016/j.ctim.2024.103052
Huaixing Cui , Naijin Zhang , JiaLi An , Xianyue Zeng , Ye Zhao , Xuan Sun , Huaien Bu , Hongwu Wang
Objective
The purpose of this systematic review was to examine the association between folic acid supplementation during pregnancy and the risk of preeclampsia.
Methods
Relevant studies were included by searching Embase, PubMed, Scope, Web of science, Cochrane Library databases. Studies were reviewed according to prespecified inclusion and exclusion criteria. Study characteristics were summarized, and study quality was assessed. Risk ratios (RR) and 95 % confidence intervals (CI) were used as indicators of effect to assess the relationship between folic acid supplementation and risk of preeclampsia.
Results
The protocol of this study was prospectively registered with the PROSPERO (registration No. CRD42022380636). A total of nine studies were included, divided into three groups according to the type of study, containing a total of 107 051 and 105 222 women who were supplemented and not supplemented with folic acid during pregnancy. The results showed that folic acid supplementation during pregnancy could not be proven to reduce the risk of preeclampsia.
Conclusion
The results of the study suggest that folic acid supplementation alone is not associated with a decreased risk of pre-eclampsia,but the inferences are somewhat limited by the low methodological quality of the included literature, and therefore higher quality studies are needed to prove this point.
{"title":"Maternal folic acid supplementation to prevent preeclampsia: a systematic review and meta-analysis","authors":"Huaixing Cui , Naijin Zhang , JiaLi An , Xianyue Zeng , Ye Zhao , Xuan Sun , Huaien Bu , Hongwu Wang","doi":"10.1016/j.ctim.2024.103052","DOIUrl":"10.1016/j.ctim.2024.103052","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of this systematic review was to examine the association between folic acid supplementation during pregnancy and the risk of preeclampsia.</p></div><div><h3>Methods</h3><p>Relevant studies were included by searching Embase, PubMed, Scope, Web of science, Cochrane Library databases. Studies were reviewed according to prespecified inclusion and exclusion criteria. Study characteristics were summarized, and study quality was assessed. Risk ratios (RR) and 95<!--> <!-->% confidence intervals (CI) were used as indicators of effect to assess the relationship between folic acid supplementation and risk of preeclampsia.</p></div><div><h3>Results</h3><p>The protocol of this study was prospectively registered with the PROSPERO (registration No. CRD42022380636). A total of nine studies were included, divided into three groups according to the type of study, containing a total of 107 051 and 105 222 women who were supplemented and not supplemented with folic acid during pregnancy. The results showed that folic acid supplementation during pregnancy could not be proven to reduce the risk of preeclampsia.</p></div><div><h3>Conclusion</h3><p>The results of the study suggest that folic acid supplementation alone is not associated with a decreased risk of pre-eclampsia,but the inferences are somewhat limited by the low methodological quality of the included literature, and therefore higher quality studies are needed to prove this point.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"82 ","pages":"Article 103052"},"PeriodicalIF":3.6,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000402/pdfft?md5=c558a71e2b030f4264033a15a9acd949&pid=1-s2.0-S0965229924000402-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141049452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acupuncture stands out as a prominent complementary and alternative medicine therapy employed for functional dyspepsia (FD). We conducted a Bayesian meta-analysis to ascertain both the relative effectiveness and safety of various acupuncture methods in the treatment of functional dyspepsia.
Methods
We systematically searched eight electronic databases, spanning from their inception to April 2023. The eligibility criteria included randomized controlled trials investigating acupuncture treatments for FD. Study appraisal was conducted using the Cochrane risk of bias tool. Pairwise and network meta-analyses were conducted using RevMan 5.3 and ADDIS V.1.16.6 software. Bayesian network meta-analysis was performed to compare and rank the efficacy of different acupuncture therapies for FD symptoms.
Results
This study found that combining different acupuncture methods or using acupuncture in conjunction with Western medicine is more effective in improving symptoms of functional dyspepsia compared to using Western medicine alone. According to the comprehensive analysis results, notably, the combination of Western medicine and acupuncture exhibited superior efficacy in alleviating early satiation and postprandial fullness symptoms. For ameliorating epigastric pain, acupuncture combined with moxibustion proved to be the most effective treatment, while moxibustion emerged as the optimal choice for addressing burning sensations. Warming needle was identified as the preferred method for promoting motilin levels.
Conclusion
The findings of this study demonstrate that acupuncture, both independently and in conjunction with other modalities, emerged as a secure and effective treatment option for patients with functional dyspepsia.
{"title":"Acupuncture for functional dyspepsia: Bayesian meta-analysis","authors":"Xiaoyun Liao , Yu Tian , Yajun Zhang , Zhiyuan Bian , Pingzhu Wang , Peiqi Li , Jianqiao Fang , Xiaomei Shao","doi":"10.1016/j.ctim.2024.103051","DOIUrl":"10.1016/j.ctim.2024.103051","url":null,"abstract":"<div><h3>Background</h3><p>Acupuncture stands out as a prominent complementary and alternative medicine therapy employed for functional dyspepsia (FD). We conducted a Bayesian meta-analysis to ascertain both the relative effectiveness and safety of various acupuncture methods in the treatment of functional dyspepsia.</p></div><div><h3>Methods</h3><p>We systematically searched eight electronic databases, spanning from their inception to April 2023. The eligibility criteria included randomized controlled trials investigating acupuncture treatments for FD. Study appraisal was conducted using the Cochrane risk of bias tool. Pairwise and network meta-analyses were conducted using RevMan 5.3 and ADDIS V.1.16.6 software. Bayesian network meta-analysis was performed to compare and rank the efficacy of different acupuncture therapies for FD symptoms.</p></div><div><h3>Results</h3><p>This study found that combining different acupuncture methods or using acupuncture in conjunction with Western medicine is more effective in improving symptoms of functional dyspepsia compared to using Western medicine alone. According to the comprehensive analysis results, notably, the combination of Western medicine and acupuncture exhibited superior efficacy in alleviating early satiation and postprandial fullness symptoms. For ameliorating epigastric pain, acupuncture combined with moxibustion proved to be the most effective treatment, while moxibustion emerged as the optimal choice for addressing burning sensations. Warming needle was identified as the preferred method for promoting motilin levels.</p></div><div><h3>Conclusion</h3><p>The findings of this study demonstrate that acupuncture, both independently and in conjunction with other modalities, emerged as a secure and effective treatment option for patients with functional dyspepsia.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"82 ","pages":"Article 103051"},"PeriodicalIF":3.6,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000396/pdfft?md5=53b6403007cccbb308c3731c722995bd&pid=1-s2.0-S0965229924000396-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To determine the effect of oral Lavandula angustifolia Mill. essential oil (LEO) on menopausal symptoms, serum cortisol level, and lipid profile in postmenopausal women.
Methods
This was a triple-blind parallel-armed randomized trial. Seventy-two postmenopausal women aged 50–65 years referring to healthcare centers in Tabriz, Iran with a score of 15–42 on the Green scale were included from May 10, 2022 to May 22, 2023. The participants were randomly assigned to two groups with a 1:1 ratio and using four and six blocks. One group received LEO soft gel 80 mg per day, and another group received a similar placebo for 60 days. A demographic questionnaire and a Greene menopause symptom scale were used for data collection. The lipid profile (total cholesterol, triglyceride, LDL, HDL) and the serum levels of cortisol were measured using biochemical methods. Chi-square, Fisher's exact tests, Independent samples t-test, Analysis of Covariance (ANCOVA), Repeated measure ANOVA, and Paired sample t-test were utilized for analyses. A p-value less than 0.05 was considered statistically significant.
Results
The demographic and personal characteristics of the participants were similar. After two months of intervention, all symptoms in psychological, physical, vasomotor, anxiety, depression, and sexual dysfunction domains were significantly relieved (decreased) among both groups (p < 0.003), except for sexual dysfunction, the reduction of which was not significant in the placebo group (p = 0.317). The mean (SD) total score of menopausal symptoms reduced from 27.4 (6.3) at baseline to 17.7 (4.9) at the end of the study in the LEO group (p < 0.001). It also decreased from 27.4 (7.1) to 17.6 (5.1) in the placebo group (p < 0.001). However, between-group analyses revealed that this reduction was significantly greater in the LEO group compared to the placebo group only in the sexual dysfunction (Mean (SD): 1.3 (0.6) vs. 1.0 (0.5); adjusted mean difference (95% confidence interval); p: − 0.35 (−0.67 to −0.02); 0.039). No significant within-group changes or between-group differences were observed (p > 0.05) in terms of studied serum markers.
Conclusion
The oral LEO exhibited a significant enhancement in sexual dysfunction among postmenopausal women. Therefore, it can be used alongside other therapies to improve sexual dysfunction during menopause. LEO did not affect lipid profile and serum cortisol level in this study.
摘要确定口服薰衣草精油（LEO）对绝经后妇女更年期症状、血清皮质醇水平和血脂状况的影响：这是一项三盲平行臂随机试验。从 2022 年 5 月 10 日至 2023 年 5 月 22 日，72 名 50-65 岁的绝经后妇女到伊朗大不里士的医疗中心就诊，格林量表评分为 15-42 分。参与者按 1:1 的比例随机分配到两组，分别使用 4 块和 6 块。一组每天服用80毫克的LEO软凝胶，另一组服用类似的安慰剂，为期60天。数据收集采用人口统计学问卷和格林更年期症状量表。采用生化方法测量血脂概况（总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白）和血清皮质醇水平。分析采用了卡方检验、费雪精确检验、独立样本 t 检验、协方差分析 (ANCOVA)、重复测量方差分析和配对样本 t 检验。P 值小于 0.05 即为具有统计学意义：结果：参与者的人口统计学特征和个人特征相似。干预两个月后，从研究的血清指标来看，两组患者在心理、生理、血管运动、焦虑、抑郁和性功能障碍方面的所有症状均明显缓解（减轻）（P 0.05）：结论：口服 LEO 能明显改善绝经后妇女的性功能障碍。结论：口服 LEO 能明显改善绝经后妇女的性功能障碍，因此可与其他疗法一起用于改善绝经期性功能障碍。在这项研究中，LEO对血脂和血清皮质醇水平没有影响。
{"title":"The efficacy of oral Lavandula angustifolia Mill. essential oil on menopausal symptoms, serum lipid profile, and cortisol concentration in postmenopausal women: A triple-blind, randomized, controlled trial","authors":"Morteza Haramshahi , Soraya Babaie , Mahnaz Shahnazi , Behnam Kafil , Azizeh Farshbaf-Khalili , Mina Naghdi","doi":"10.1016/j.ctim.2024.103050","DOIUrl":"10.1016/j.ctim.2024.103050","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the effect of oral Lavandula angustifolia Mill. essential oil (LEO) on menopausal symptoms, serum cortisol level, and lipid profile in postmenopausal women.</p></div><div><h3>Methods</h3><p>This was a triple-blind parallel-armed randomized trial. Seventy-two postmenopausal women aged 50–65 years referring to healthcare centers in Tabriz, Iran with a score of 15–42 on the Green scale were included from May 10, 2022 to May 22, 2023. The participants were randomly assigned to two groups with a 1:1 ratio and using four and six blocks. One group received LEO soft gel 80 mg per day, and another group received a similar placebo for 60 days. A demographic questionnaire and a Greene menopause symptom scale were used for data collection. The lipid profile (total cholesterol, triglyceride, LDL, HDL) and the serum levels of cortisol were measured using biochemical methods. Chi-square, Fisher's exact tests, Independent samples t-test, Analysis of Covariance (ANCOVA), Repeated measure ANOVA, and Paired sample t-test were utilized for analyses. A p-value less than 0.05 was considered statistically significant.</p></div><div><h3>Results</h3><p>The demographic and personal characteristics of the participants were similar. After two months of intervention, all symptoms in psychological, physical, vasomotor, anxiety, depression, and sexual dysfunction domains were significantly relieved (decreased) among both groups (p < 0.003), except for sexual dysfunction, the reduction of which was not significant in the placebo group (p = 0.317). The mean (SD) total score of menopausal symptoms reduced from 27.4 (6.3) at baseline to 17.7 (4.9) at the end of the study in the LEO group (p < 0.001). It also decreased from 27.4 (7.1) to 17.6 (5.1) in the placebo group (p < 0.001). However, between-group analyses revealed that this reduction was significantly greater in the LEO group compared to the placebo group only in the sexual dysfunction (Mean (SD): 1.3 (0.6) vs. 1.0 (0.5); adjusted mean difference (95% confidence interval); p: − 0.35 (−0.67 to −0.02); 0.039). No significant within-group changes or between-group differences were observed (p > 0.05) in terms of studied serum markers.</p></div><div><h3>Conclusion</h3><p>The oral LEO exhibited a significant enhancement in sexual dysfunction among postmenopausal women. Therefore, it can be used alongside other therapies to improve sexual dysfunction during menopause. LEO did not affect lipid profile and serum cortisol level in this study.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"82 ","pages":"Article 103050"},"PeriodicalIF":3.6,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000384/pdfft?md5=d620aec51a85eca1632a64b596be38fb&pid=1-s2.0-S0965229924000384-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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