Pub Date : 2024-04-10DOI: 10.1016/j.ctim.2024.103040
V. Bellisario , G. Squillacioti , F. Ghelli , MC. Monti , L. Correale , C. Montomoli , R. Bono
Objectives
Due to the inflammatory nature of multiple sclerosis (MS), the most widely used therapeutic approach targets the immune response but can comprise side effects (e.g. secondary immunosuppression). For these reasons, among non-pharmaceutical interventions without known side effects, physical activity (PA) gained importance because it is feasible, safe and a supportive complementary treatment strategy to alleviate symptoms in MS subjects. Consequently, the main aim of this systematic review is to analyze the effect of PA protocols, as a complementary therapy, on inflammatory status in MS patients.
Methods
Four electronic databases (PubMed, Embase, CINAHL, and Cochrane CENTRAL) were systematically searched up to 01 June 2023 (Prospero Protocol ID=CRD42021244418). The refined search strategy was based on three concepts: “MULTIPLE SCLEROSIS” AND “PHYSICAL ACTIVITY” AND “INFLAMMATION”.
Results
three main findings emerged: 1) untrained subjects showed a negative modulation of inflammatory biomarkers concentrations when compared to trained people (−0.74, 95 %C.I.–1.16, −0.32); 2) training modulated positively inflammatory biomarkers (+0.47, 95 %C.I. 0.24,0.71); 3) Aerobic PA protocol enhance higher positive influence on inflammation.
Conclusions
Persistent, low-grade inflammation in MS could be upregulated by non-pharmacological complementary therapies, in particular by regular aerobic PA that could reduce and positively modulate inflammation.
{"title":"Inflammation and physical activity in multiple sclerosis patients. A systematic review and meta-analysis","authors":"V. Bellisario , G. Squillacioti , F. Ghelli , MC. Monti , L. Correale , C. Montomoli , R. Bono","doi":"10.1016/j.ctim.2024.103040","DOIUrl":"https://doi.org/10.1016/j.ctim.2024.103040","url":null,"abstract":"<div><h3>Objectives</h3><p>Due to the inflammatory nature of multiple sclerosis (MS), the most widely used therapeutic approach targets the immune response but can comprise side effects (e.g. secondary immunosuppression). For these reasons, among non-pharmaceutical interventions without known side effects, physical activity (PA) gained importance because it is feasible, safe and a supportive complementary treatment strategy to alleviate symptoms in MS subjects. Consequently, the main aim of this systematic review is to analyze the effect of PA protocols, as a complementary therapy, on inflammatory status in MS patients.</p></div><div><h3>Methods</h3><p>Four electronic databases (PubMed, Embase, CINAHL, and Cochrane CENTRAL) were systematically searched up to 01 June 2023 (Prospero Protocol ID=CRD42021244418). The refined search strategy was based on three concepts: “MULTIPLE SCLEROSIS” AND “PHYSICAL ACTIVITY” AND “INFLAMMATION”.</p></div><div><h3>Results</h3><p>three main findings emerged: 1) untrained subjects showed a negative modulation of inflammatory biomarkers concentrations when compared to trained people (−0.74, 95 %C.I.–1.16, −0.32); 2) training modulated positively inflammatory biomarkers (+0.47, 95 %C.I. 0.24,0.71); 3) Aerobic PA protocol enhance higher positive influence on inflammation.</p></div><div><h3>Conclusions</h3><p>Persistent, low-grade inflammation in MS could be upregulated by non-pharmacological complementary therapies, in particular by regular aerobic PA that could reduce and positively modulate inflammation.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000281/pdfft?md5=05eacc8e6ea962fc12bbb28f9181a4fe&pid=1-s2.0-S0965229924000281-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140550848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.1016/j.ctim.2024.103038
Yi-ping Song , Jia-li Liu , Chen-zhong Zong , Fang-shuo Zhang , Yan-feng Ren , Yuen-Lim Ching , Yi-xiao Wang , Wen-xun Li , He Zhao , Yi-ran Huang , Kuo Gao
Objective
An increasing body of evidence suggests a positive role of chiropractic in the treatment of neuro-musculoskeletal disorders. This study aims to explore current research hotspots and trends, providing insights into the broad prospects of this field.
Methods
A bibliometric review was conducted on all chiropractic articles included in the Web of Science Core Collection before December 31, 2023.
Results
Over the past century, the volume of research in the field of chiropractic has been fluctuating annually, with four peaks observed in total. The United States, Canada, Australia, and the United Kingdom are leading countries. Chu, Eric Chun-Pu is the author with the most publications, while Bronfort, Gert has the highest total citation count. The University of Southern Denmark has produced the most publications, while Queens University - Canada is the most central institution. The Journal of Manipulative and Physiological Therapeutics is the journal with the most publications and citations, while the Journal of the American Medical Association is the most central journal. The two most-cited articles were both authored by Eisenberg DM. Emerging keywords include "chronic pain" and "skills". The theoretical mechanisms and scientific basis of chiropractic, its clinical practice and safety, education and training, integration with other disciplines, and patient experiences and satisfaction are the frontiers and hotspots of research.
Conclusion
This study integrates bibliometric analysis to summarize the current state of research and global network centers in the field of chiropractic, further highlighting the hotspots and trends in this field. However, Individual and national rankings should be interpreted with caution due to our focus on Web of Science rather than PubMed.
目的 越来越多的证据表明，整脊疗法在治疗神经-肌肉-骨骼疾病方面发挥着积极作用。本研究旨在探讨当前的研究热点和趋势，为这一领域的广阔前景提供见解。研究方法对2023年12月31日之前收录在《科学网》（Web of Science）核心文献集中的所有脊骨神经医学论文进行了文献计量学回顾。美国、加拿大、澳大利亚和英国居于领先地位。朱春璞是发表论文最多的作者，而格特-布朗福特则是总引用次数最多的作者。南丹麦大学（University of Southern Denmark）发表的论文最多，而加拿大皇后大学（Queens University - Canada）则是最核心的机构。手法与生理治疗学杂志》是发表文章和被引用次数最多的杂志，而《美国医学会杂志》则是最重要的杂志。被引用次数最多的两篇文章均由 Eisenberg DM 撰写。新出现的关键词包括 "慢性疼痛 "和 "技能"。脊骨神经科学的理论机制与科学基础、临床实践与安全性、教育与培训、与其他学科的整合、患者体验与满意度是研究的前沿和热点。结论本研究综合文献计量学分析，总结了脊骨神经科学领域的研究现状和全球网络中心，进一步突出了该领域的热点和趋势。然而，由于我们关注的是Web of Science而不是PubMed，因此在解释个人和国家排名时应谨慎。
{"title":"A bibliometric study on trends in chiropractic research from 1920 to 2023","authors":"Yi-ping Song , Jia-li Liu , Chen-zhong Zong , Fang-shuo Zhang , Yan-feng Ren , Yuen-Lim Ching , Yi-xiao Wang , Wen-xun Li , He Zhao , Yi-ran Huang , Kuo Gao","doi":"10.1016/j.ctim.2024.103038","DOIUrl":"https://doi.org/10.1016/j.ctim.2024.103038","url":null,"abstract":"<div><h3>Objective</h3><p>An increasing body of evidence suggests a positive role of chiropractic in the treatment of neuro-musculoskeletal disorders. This study aims to explore current research hotspots and trends, providing insights into the broad prospects of this field.</p></div><div><h3>Methods</h3><p>A bibliometric review was conducted on all chiropractic articles included in the Web of Science Core Collection before December 31, 2023.</p></div><div><h3>Results</h3><p>Over the past century, the volume of research in the field of chiropractic has been fluctuating annually, with four peaks observed in total. The United States, Canada, Australia, and the United Kingdom are leading countries. Chu, Eric Chun-Pu is the author with the most publications, while Bronfort, Gert has the highest total citation count. The University of Southern Denmark has produced the most publications, while Queens University - Canada is the most central institution. The Journal of Manipulative and Physiological Therapeutics is the journal with the most publications and citations, while the Journal of the American Medical Association is the most central journal. The two most-cited articles were both authored by Eisenberg DM. Emerging keywords include \"chronic pain\" and \"skills\". The theoretical mechanisms and scientific basis of chiropractic, its clinical practice and safety, education and training, integration with other disciplines, and patient experiences and satisfaction are the frontiers and hotspots of research.</p></div><div><h3>Conclusion</h3><p>This study integrates bibliometric analysis to summarize the current state of research and global network centers in the field of chiropractic, further highlighting the hotspots and trends in this field. However, Individual and national rankings should be interpreted with caution due to our focus on Web of Science rather than PubMed.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000268/pdfft?md5=dc0e044272d22621e0d3ee622650dd90&pid=1-s2.0-S0965229924000268-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140533707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.1016/j.ctim.2024.103037
Huifang Luo , Ping Du , Wenyan Qin , Yiyi Hu , Zhen Xian , Changsong Lin , Peiwu Li , Yang Song , Xiangwei Yang
Background and purpose
Rheumatoid arthritis (RA) is called “immortal cancer”, and it affects the quality of life, disability rate and even the survival of patients. This study aimed to observe the clinical efficacy, and adverse reactions of intradermal acupuncture (IA) in the treatment of RA patients with liver and kidney deficiency syndrome.
Materials and methods
132 RA patients were split into an IA group and a sham IA group at a 1:1 ratio. Both groups were assessed before and after the intervention with the assessments: a traditional Chinese medicine (TCM) syndrome evaluation, the Health Assessment Questionnaire (HAQ), the Disease Activity Score 28 (DAS28) and serum C-reactive protein (CRP).
Results
There was a statistically significant difference in TCM syndrome evaluation, HAQ, DAS28, and CRP between both groups before and after treatment (P < 0.01). The improvement of TCM syndrome evaluation (95% CI [1.14(0.38–1.89)]; P = 0.001), HAQ (95% CI [2.00(1.00–3.00)]; P = 0.003), and DAS28 (95% CI [0.11(0.02–0.20)]; P = 0.021) in the IA group was more obvious than that in the sham IA group (P < 0.05), except for CRP (95% CI [0.50(− 2.09 to 7.08)], P = 0.786). The difference in CRP outcome changes between the two groups was not statistically significant (P > 0.05). Both groups had comparable results in the implementation of RA in the upper and lower extremity acupoints and did not differ due to different sites (IA group: P = 0.852; sham IA group: P = 0.861). The comparison of effective rate of the upper limb as well as that of the lower limb was statistically significant (P = 0.001). Besides, patients reported no adverse effects.
Conclusion
The IA intervention was associated with a promising effect on the decrease in RA disease activity and delayed overall disease progression.
背景与目的类风湿性关节炎（RA）被称为 "不死的癌症"，影响患者的生活质量、致残率甚至生存。本研究旨在观察皮内针刺（IA）治疗RA肝肾亏虚证患者的临床疗效及不良反应。两组患者在干预前后均接受了中医证候评估、健康评估问卷（HAQ）、疾病活动度评分28（DAS28）和血清C反应蛋白（CRP）的评估。结果两组患者在治疗前后的中医证候评估、HAQ、DAS28和CRP差异均有统计学意义（P < 0.01）。中医综合征评估（95% CI [1.14(0.38-1.89)]；P = 0.001）、HAQ（95% CI [2.00(1.00-3.00)]；P = 0.003）和 DAS28（95% CI [0.11(0.02-0.20）]；P = 0.021），除CRP（95% CI [0.50(- 2.09 to 7.08)]，P = 0.786）外，IA组较假IA组明显（P < 0.05）。两组 CRP 结果变化的差异无统计学意义（P > 0.05）。两组在上肢和下肢穴位实施 RA 的效果相当，没有因部位不同而产生差异（IA 组：P = 0.852；假 IA 组：P = 0.861）。上肢和下肢的有效率比较有统计学意义（P = 0.001）。此外，患者未报告任何不良反应。
{"title":"Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome – A sham-controlled, randomized, clinical trial","authors":"Huifang Luo , Ping Du , Wenyan Qin , Yiyi Hu , Zhen Xian , Changsong Lin , Peiwu Li , Yang Song , Xiangwei Yang","doi":"10.1016/j.ctim.2024.103037","DOIUrl":"https://doi.org/10.1016/j.ctim.2024.103037","url":null,"abstract":"<div><h3>Background and purpose</h3><p>Rheumatoid arthritis (RA) is called “immortal cancer”, and it affects the quality of life, disability rate and even the survival of patients. This study aimed to observe the clinical efficacy, and adverse reactions of intradermal acupuncture (IA) in the treatment of RA patients with liver and kidney deficiency syndrome.</p></div><div><h3>Materials and methods</h3><p>132 RA patients were split into an IA group and a sham IA group at a 1:1 ratio. Both groups were assessed before and after the intervention with the assessments: a traditional Chinese medicine (TCM) syndrome evaluation, the Health Assessment Questionnaire (HAQ), the Disease Activity Score 28 (DAS28) and serum C-reactive protein (CRP).</p></div><div><h3>Results</h3><p>There was a statistically significant difference in TCM syndrome evaluation, HAQ, DAS28, and CRP between both groups before and after treatment (<em>P</em> < 0.01). The improvement of TCM syndrome evaluation (95% <em>CI</em> [1.14(0.38–1.89)]; <em>P</em> = 0.001), HAQ (95% <em>CI</em> [2.00(1.00–3.00)]; <em>P</em> = 0.003), and DAS28 (95% <em>CI</em> [0.11(0.02–0.20)]; <em>P</em> = 0.021) in the IA group was more obvious than that in the sham IA group (<em>P</em> < 0.05), except for CRP (95% <em>CI</em> [0.50(− 2.09 to 7.08)], <em>P</em> = 0.786). The difference in CRP outcome changes between the two groups was not statistically significant (<em>P</em> > 0.05). Both groups had comparable results in the implementation of RA in the upper and lower extremity acupoints and did not differ due to different sites (IA group: <em>P</em> = 0.852; sham IA group: <em>P</em> = 0.861). The comparison of effective rate of the upper limb as well as that of the lower limb was statistically significant (<em>P</em> = 0.001). Besides, patients reported no adverse effects.</p></div><div><h3>Conclusion</h3><p>The IA intervention was associated with a promising effect on the decrease in RA disease activity and delayed overall disease progression.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000256/pdfft?md5=9dffba969dbaa5db1ee0e86a752929e1&pid=1-s2.0-S0965229924000256-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140539904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-21DOI: 10.1016/j.ctim.2024.103034
Tingting Lu , Bin Liu , Cuncun Lu , Zouxi Du , Kehu Yang , Long Ge
Objective
Acupuncture overviews are increasing rapidly; however, their reporting quality is yet unclear. We aimed to investigate the reporting quality of relevant overviews according to the preferred reporting items for overviews of reviews (PRIOR) statement.
Methods
We systematically searched PubMed from inception to August 16, 2022 for overviews on acupuncture therapies. Reporting quality of included overviews was evaluated using the PRIOR statement, and the results were cross-checked. Multiple linear regression analysis was used to assess the predictors of the reporting completeness. GraphPad 9.4 was utilized to generate an evidence map, Excel 2019 was used to extract and manage data, and R 4.2.3 was used for data analysis.
Results
A total of 49 overviews published from 2006 to 2022 were included, of which China ranked first with 38 overviews. The most frequently searched database was PubMed/ Medline (n = 48, 98%), and commonly used methodological quality assessment tool was AMSTAR-2 (n = 14, 29%). The overarching themes centered on acupuncture for obstetrics, gynecology, reproductive diseases, as well as depression, anxiety, and insomnia. Reporting quality needs to be improved involving the definition of systematic reviews (SRs), overlap of primary studies and SRs, methods for managing discrepant data across SRs, risk of bias in primary studies, heterogeneity, and sensitivity analysis of synthesized results, reporting bias assessment, and registration and protocol. Moreover, publication in recent years and receiving funding support were significantly associated with higher overall reporting quality score (P < 0.05).
Conclusion
Based on the PRIOR statement, this methodological study indicates that the reporting quality of the included acupuncture overviews is poor. In the future, authors of overviews are encouraged to use the PRIOR statement for standardized reporting. Furthermore, it is recommended that journal editors mandate the inclusion of this statement in authors’ reports and require a complete PRIOR checklist.
{"title":"Reporting quality of acupuncture overviews: A methodological investigation based on the PRIOR statement","authors":"Tingting Lu , Bin Liu , Cuncun Lu , Zouxi Du , Kehu Yang , Long Ge","doi":"10.1016/j.ctim.2024.103034","DOIUrl":"10.1016/j.ctim.2024.103034","url":null,"abstract":"<div><h3>Objective</h3><p>Acupuncture overviews are increasing rapidly; however, their reporting quality is yet unclear. We aimed to investigate the reporting quality of relevant overviews according to the preferred reporting items for overviews of reviews (PRIOR) statement.</p></div><div><h3>Methods</h3><p>We systematically searched PubMed from inception to August 16, 2022 for overviews on acupuncture therapies. Reporting quality of included overviews was evaluated using the PRIOR statement, and the results were cross-checked. Multiple linear regression analysis was used to assess the predictors of the reporting completeness. GraphPad 9.4 was utilized to generate an evidence map, Excel 2019 was used to extract and manage data, and R 4.2.3 was used for data analysis.</p></div><div><h3>Results</h3><p>A total of 49 overviews published from 2006 to 2022 were included, of which China ranked first with 38 overviews. The most frequently searched database was PubMed/ Medline (n = 48, 98%), and commonly used methodological quality assessment tool was AMSTAR-2 (n = 14, 29%). The overarching themes centered on acupuncture for obstetrics, gynecology, reproductive diseases, as well as depression, anxiety, and insomnia. Reporting quality needs to be improved involving the definition of systematic reviews (SRs), overlap of primary studies and SRs, methods for managing discrepant data across SRs, risk of bias in primary studies, heterogeneity, and sensitivity analysis of synthesized results, reporting bias assessment, and registration and protocol. Moreover, publication in recent years and receiving funding support were significantly associated with higher overall reporting quality score (<em>P</em> < 0.05).</p></div><div><h3>Conclusion</h3><p>Based on the PRIOR statement, this methodological study indicates that the reporting quality of the included acupuncture overviews is poor. In the future, authors of overviews are encouraged to use the PRIOR statement for standardized reporting. Furthermore, it is recommended that journal editors mandate the inclusion of this statement in authors’ reports and require a complete PRIOR checklist.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000220/pdfft?md5=c7575e4a220e0cbb1137a40e795af125&pid=1-s2.0-S0965229924000220-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.1016/j.ctim.2024.103035
Oh-Bin Kwon , Dong Wook Hwang , Dong-Hyeob Kang , Sang-Joon Yoo , Do-Hoon Lee , Minjin Kwon , Seon-Woo Jang , Hyun-Woo Cho , Sang Don Kim , Kyong Sun Park , Eun-San Kim , Yoon Jae Lee , Doori Kim , In-Hyuk Ha
Background and purpose
This parallel, single-center, pragmatic, randomized controlled study aimed to investigate the effectiveness and safety of motion style acupuncture treatment (MSAT; a combination of acupuncture and Doin therapy) to reduce pain and improve the functional disability of patients with acute low back pain (aLBP) due to road traffic accidents.
Materials and Methods
Ninety-six patients with aLBP admitted to the Haeundae Jaseng Hospital of Korean Medicine in South Korea due to traffic accidents were treated with integrative Korean medicine (IKM) with additional 3-day MSAT sessions during hospitalization (MSAT group, 48 patients) or without (control group, 48 patients), and followed up for 90 days.
Results
The mean numeric rating scale (NRS) scores of low back pain (LBP) of the MSAT and control groups were both 6.7 (95% confidence interval [CI]: 6.3, 7.1) at baseline. After completing the third round of all applicable treatment sessions (the primary endpoint in this study), the mean NRS scores of the MSAT and control groups were 3.76 (95% CI: 3.54, 3.99) and 5.32 (95% CI: 5.09, 5.55), respectively. The difference in the mean NRS score between the two groups was 1.56 (95% CI: 1.25, 1.87).
Conclusion
IKM treatment combined with MSAT can reduce pain and improve the range of motion of patients with aLBP.
Trial registration
This trial is registered at ClinicalTrial.gov (NCT04956458).
{"title":"Effectiveness of lumbar motion style acupuncture treatment on inpatients with acute low back pain: A pragmatic, randomized controlled trial","authors":"Oh-Bin Kwon , Dong Wook Hwang , Dong-Hyeob Kang , Sang-Joon Yoo , Do-Hoon Lee , Minjin Kwon , Seon-Woo Jang , Hyun-Woo Cho , Sang Don Kim , Kyong Sun Park , Eun-San Kim , Yoon Jae Lee , Doori Kim , In-Hyuk Ha","doi":"10.1016/j.ctim.2024.103035","DOIUrl":"10.1016/j.ctim.2024.103035","url":null,"abstract":"<div><h3>Background and purpose</h3><p>This parallel, single-center, pragmatic, randomized controlled study aimed to investigate the effectiveness and safety of motion style acupuncture treatment (MSAT; a combination of acupuncture and Doin therapy) to reduce pain and improve the functional disability of patients with acute low back pain (aLBP) due to road traffic accidents.</p></div><div><h3>Materials and Methods</h3><p>Ninety-six patients with aLBP admitted to the Haeundae Jaseng Hospital of Korean Medicine in South Korea due to traffic accidents were treated with integrative Korean medicine (IKM) with additional 3-day MSAT sessions during hospitalization (MSAT group, 48 patients) or without (control group, 48 patients), and followed up for 90 days.</p></div><div><h3>Results</h3><p>The mean numeric rating scale (NRS) scores of low back pain (LBP) of the MSAT and control groups were both 6.7 (95% confidence interval [CI]: 6.3, 7.1) at baseline. After completing the third round of all applicable treatment sessions (the primary endpoint in this study), the mean NRS scores of the MSAT and control groups were 3.76 (95% CI: 3.54, 3.99) and 5.32 (95% CI: 5.09, 5.55), respectively. The difference in the mean NRS score between the two groups was 1.56 (95% CI: 1.25, 1.87).</p></div><div><h3>Conclusion</h3><p>IKM treatment combined with MSAT can reduce pain and improve the range of motion of patients with aLBP.</p></div><div><h3>Trial registration</h3><p>This trial is registered at ClinicalTrial.gov (NCT04956458).</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000232/pdfft?md5=b14ec800fc780b1f2d2f82fc15bf7167&pid=1-s2.0-S0965229924000232-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-06DOI: 10.1016/j.ctim.2024.103033
Siyang Peng , Linghao Meng , Ruiying Fang , Qiqi Shen , Yukun Tian , Anni Xiong , Shaohong Li , Yajing Yang , Weiqian Chang , Jinxia Ni , Wenzeng Zhu
Objective
To provide a comprehensive overview of existing evidence, research gaps, and future research priorities concerning the treatment of myasthenia gravis (MG) using exercise therapies.
Method
Clinical studies on exercise treatment for MG were searched in nine databases to conduct a scoping review. Two independent researchers screened the literature and comprehensively analyzed the characteristics and limitations of the included articles.
Results
A total of 5725 studies were retrieved, of which 24 were included. The included studies were conducted in 16 different countries/regions and 456 patients were enrolled. Study designs included both interventional and observational studies. Exercise interventions included aerobic exercise, resistance exercise, balance training, and stretch training, and are typically administered in conjunction with medication, usual care, or some other interventions. The intensity, frequency, and duration of exercise interventions varied hugely among studies. Six-minute walk test, adverse events, muscle strength, MG quality of life-15 scale, forced vital capacity, quantitative MG scale, and MG activities of daily living scale were the most frequently used outcomes. All studies reported results in favor of the efficacy and safety of exercise in MG, and exercise-related adverse events were reported in two studies.
Conclusion
This scoping review provides an overview of the evidence concerning exercise treatment for MG. Key gaps in evidence include a limited number of participants, complex interventions, variability in outcome selection, and insufficient reporting in publications. The promotion of exercise treatment for MG still encounters several obstacles. A larger population, rigorous study design and conduction, standardized interventions and outcomes, and standardized reporting are essential.
{"title":"Current state of research on exercise for the treatment of myasthenia gravis: A scoping review","authors":"Siyang Peng , Linghao Meng , Ruiying Fang , Qiqi Shen , Yukun Tian , Anni Xiong , Shaohong Li , Yajing Yang , Weiqian Chang , Jinxia Ni , Wenzeng Zhu","doi":"10.1016/j.ctim.2024.103033","DOIUrl":"10.1016/j.ctim.2024.103033","url":null,"abstract":"<div><h3>Objective</h3><p>To provide a comprehensive overview of existing evidence, research gaps, and future research priorities concerning the treatment of myasthenia gravis (MG) using exercise therapies.</p></div><div><h3>Method</h3><p>Clinical studies on exercise treatment for MG were searched in nine databases to conduct a scoping review. Two independent researchers screened the literature and comprehensively analyzed the characteristics and limitations of the included articles.</p></div><div><h3>Results</h3><p>A total of 5725 studies were retrieved, of which 24 were included. The included studies were conducted in 16 different countries/regions and 456 patients were enrolled. Study designs included both interventional and observational studies. Exercise interventions included aerobic exercise, resistance exercise, balance training, and stretch training, and are typically administered in conjunction with medication, usual care, or some other interventions. The intensity, frequency, and duration of exercise interventions varied hugely among studies. Six-minute walk test, adverse events, muscle strength, MG quality of life-15 scale, forced vital capacity, quantitative MG scale, and MG activities of daily living scale were the most frequently used outcomes. All studies reported results in favor of the efficacy and safety of exercise in MG, and exercise-related adverse events were reported in two studies.</p></div><div><h3>Conclusion</h3><p>This scoping review provides an overview of the evidence concerning exercise treatment for MG. Key gaps in evidence include a limited number of participants, complex interventions, variability in outcome selection, and insufficient reporting in publications. The promotion of exercise treatment for MG still encounters several obstacles. A larger population, rigorous study design and conduction, standardized interventions and outcomes, and standardized reporting are essential.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000219/pdfft?md5=a359bf80e898fc05cff9f36a9705b1a1&pid=1-s2.0-S0965229924000219-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.1016/j.ctim.2024.103032
Jingqi Yang , Zhuoping Deng , Shichun Pei , Nan Zhang
Introduction
Therapeutic horticulture (TH) is increasingly being applied for sub-health or patient mental health care. Whether plant and activity type will affect TH’s effectiveness is unclear.
Aim
To evaluate the feasibility of an indoor TH for alleviating the anxiety symptoms and sleeping problems of people with poor sleep quality, and explore the potential affection of plant and activity type on health benefits.
Method
Thirty subjects (all with sleep problems and half with anxiety problems) were randomly assigned to three groups to do horticultural activities with ornamental plants, general aromatic plants, or aromatic plants with reported mental health functions, respectively. Six indoor TH activities were then held sequentially within two weeks. Psychological scales, subjective feedback questionnaires, and physiological indicators were used as evaluation indexes before and after horticulture activities.
Results
The TH relieved subjects' sleep and anxiety problems and was particularly effective in alleviating anxiety among people with high anxiety levels. Using ornamental plants was more effective in relieving stress while functional aromatic plants performed better in sleep improvement and satisfaction to TH. Each horticultural activity could improve mood state but showed different effects on the vitality of the participants.
Conclusion
The above findings provided some basis for the potential benefits of selecting plants and activities based on psychological care needs in the development of TH plans. Future research that expands upon the current project is warranted. A larger sample size is beneficial for obtaining more powerful statistical results.
{"title":"A feasibility study on indoor therapeutic horticulture to alleviate sleep and anxiety problems: The impact of plants and activity choice on its therapeutic effect","authors":"Jingqi Yang , Zhuoping Deng , Shichun Pei , Nan Zhang","doi":"10.1016/j.ctim.2024.103032","DOIUrl":"10.1016/j.ctim.2024.103032","url":null,"abstract":"<div><h3>Introduction</h3><p>Therapeutic horticulture (TH) is increasingly being applied for sub-health or patient mental health care. Whether plant and activity type will affect TH’s effectiveness is unclear.</p></div><div><h3>Aim</h3><p>To evaluate the feasibility of an indoor TH for alleviating the anxiety symptoms and sleeping problems of people with poor sleep quality, and explore the potential affection of plant and activity type on health benefits.</p></div><div><h3>Method</h3><p>Thirty subjects (all with sleep problems and half with anxiety problems) were randomly assigned to three groups to do horticultural activities with ornamental plants, general aromatic plants, or aromatic plants with reported mental health functions, respectively. Six indoor TH activities were then held sequentially within two weeks. Psychological scales, subjective feedback questionnaires, and physiological indicators were used as evaluation indexes before and after horticulture activities.</p></div><div><h3>Results</h3><p>The TH relieved subjects' sleep and anxiety problems and was particularly effective in alleviating anxiety among people with high anxiety levels. Using ornamental plants was more effective in relieving stress while functional aromatic plants performed better in sleep improvement and satisfaction to TH. Each horticultural activity could improve mood state but showed different effects on the vitality of the participants.</p></div><div><h3>Conclusion</h3><p>The above findings provided some basis for the potential benefits of selecting plants and activities based on psychological care needs in the development of TH plans. Future research that expands upon the current project is warranted. A larger sample size is beneficial for obtaining more powerful statistical results.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000207/pdfft?md5=ed10debcec24e43c24b94473efa0a285&pid=1-s2.0-S0965229924000207-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-02DOI: 10.1016/j.ctim.2024.103030
Jennifer Kawi , Chao Hsing Yeh , Lauren Grant , Xinran Huang , Hulin Wu , Chunyan Hua , Paul Christo
Objectives
Evaluate a digital health intervention using Auricular Point Acupressure (APA) for chronic musculoskeletal pain in terms of participant retention, adherence, acceptability, and satisfaction. Chronic musculoskeletal pain is a global concern and there are persistent challenges in pain management. Despite the value of digital health interventions, these interventions need to be fully evaluated for feasibility.
Methods
We conducted a 3-group, longitudinal, randomized controlled trial (RCT). After Institutional Review Board approval, we posted recruitment flyers in a university, healthcare clinics, and community settings. Participants were randomized into an in-person + app group (n = 8), virtual + app group (n = 7), and a wait-list, education-enhanced control group (n = 8), evaluating our outcomes using standard feasibility measures. The 4-week intervention consisted of virtual sessions, telecommunications, and our APA app, followed by a 3-month follow-up.
Results
Data from 22 participants were subsequently analyzed (95.7%). All app participants adhered to the study protocol and used APA at the minimum recommended frequency and duration. The virtual + app group used APA more during the intervention and follow-up periods. All app participants found the intervention to be acceptable and at least 80% overall were satisfied with APA at the 3-month follow-up. There were no adverse events reported.
Conclusions
Our digital health intervention was found to be acceptable and sustainable; participants adhered to and were satisfied with the intervention providing support for a larger RCT.
Clinical Trial
#: NCT05020470
目标： 评估使用耳穴指压法（APA）治疗慢性肌肉骨骼疼痛的数字健康干预措施的参与者保留率、坚持率、接受率和满意度：评估使用耳穴指压法（APA）治疗慢性肌肉骨骼疼痛的数字健康干预措施在参与者保留率、坚持率、可接受性和满意度方面的效果。慢性肌肉骨骼疼痛是全球关注的问题，在疼痛管理方面一直存在挑战。尽管数字健康干预措施很有价值，但还需要对这些干预措施的可行性进行全面评估：我们进行了一项三组纵向随机对照试验（RCT）。经机构审查委员会批准后，我们在大学、医疗诊所和社区张贴了招募传单。参与者被随机分为面对面+应用程序组（8 人）、虚拟+应用程序组（7 人）和候补名单、教育强化对照组（8 人），我们使用标准的可行性措施对结果进行评估。为期 4 周的干预包括虚拟课程、电信和我们的 APA 应用程序，然后进行为期 3 个月的随访：随后对 22 名参与者（95.7%）的数据进行了分析。所有应用程序参与者都遵守了研究方案，并按照建议的最低频率和持续时间使用了 APA。虚拟 + 应用程序组在干预和随访期间使用 APA 的频率更高。所有应用程序参与者都认为干预是可以接受的，至少有 80% 的参与者在 3 个月的随访中对 APA 表示满意。没有不良事件报告：我们的数字健康干预被认为是可接受和可持续的；参与者坚持并对干预表示满意，这为更大规模的 RCT 临床试验提供了支持：#：NCT05020470。
{"title":"Retention, adherence, and acceptability testing of a digital health intervention in a 3-group randomized controlled trial for chronic musculoskeletal pain","authors":"Jennifer Kawi , Chao Hsing Yeh , Lauren Grant , Xinran Huang , Hulin Wu , Chunyan Hua , Paul Christo","doi":"10.1016/j.ctim.2024.103030","DOIUrl":"10.1016/j.ctim.2024.103030","url":null,"abstract":"<div><h3>Objectives</h3><p>Evaluate a digital health intervention using Auricular Point Acupressure (APA) for chronic musculoskeletal pain in terms of participant retention, adherence, acceptability, and satisfaction. Chronic musculoskeletal pain is a global concern and there are persistent challenges in pain management. Despite the value of digital health interventions, these interventions need to be fully evaluated for feasibility.</p></div><div><h3>Methods</h3><p>We conducted a 3-group, longitudinal, randomized controlled trial (RCT). After Institutional Review Board approval, we posted recruitment flyers in a university, healthcare clinics, and community settings. Participants were randomized into an in-person + app group (<em>n</em> = 8), virtual + app group (<em>n</em> = 7), and a wait-list, education-enhanced control group (<em>n</em> = 8), evaluating our outcomes using standard feasibility measures. The 4-week intervention consisted of virtual sessions, telecommunications, and our APA app, followed by a 3-month follow-up.</p></div><div><h3>Results</h3><p>Data from 22 participants were subsequently analyzed (95.7%). All app participants adhered to the study protocol and used APA at the minimum recommended frequency and duration. The virtual + app group used APA more during the intervention and follow-up periods. All app participants found the intervention to be acceptable and at least 80% overall were satisfied with APA at the 3-month follow-up. There were no adverse events reported.</p></div><div><h3>Conclusions</h3><p>Our digital health intervention was found to be acceptable and sustainable; participants adhered to and were satisfied with the intervention providing support for a larger RCT.</p></div><div><h3>Clinical Trial</h3><p>#: NCT05020470</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000189/pdfft?md5=0965e1355678f278e3eb4d3b5f82f23e&pid=1-s2.0-S0965229924000189-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-02DOI: 10.1016/j.ctim.2024.103031
Rebecca Büttner , Melanie Schwermer , Thomas Ostermann , Alfred Längler , Tycho Zuzak
Background
Medical guidelines are an important basis for qualitative and cost-effective patient care. However, there is a lack of clinical recommendations in anthroposophic medicine (AM), an integrative medicine approach frequently practised in Europe. Acute tonsillitis, which includes tonsillopharyngitis, is a common childhood disease. that is mostly caused by a viral infection. Symptomatic treatment is therefore of high importance, and AM can offer several therapy options.
Methods
53 physicians from Germany, Spain, Netherlands, Switzerland, Austria, and Hungary with at least one year of experience in anthroposophic paediatric medicine were invited to participate in an online Delphi process. The process comprises five survey rounds starting with open-ended questions and ending with final statements, which need 75% agreement of experts to reach consensus. Expert answers were evaluated by two independent reviewers using MAXQDA and Excel.
Results
Response rate was between 28% and 45%. The developed recommendation included 15 subtopics. These covered clinical, diagnostic, therapeutic and psychosocial aspects of acute tonsillitis. Six subtopics achieved a high consensus (>90%) and nine subtopics achieved consensus (75–90%).
Conclusion
The clinical recommendation for acute tonsillitis in children aims to simplify everyday patient care and provide decision-making support when considering and prescribing anthroposophic therapies. Moreover, the recommendation makes AM more transparent for physicians, parents, and maybe political stakeholders as well.
{"title":"Expert consensus-based clinical recommendation for an integrative anthroposophic treatment approach to acute tonsillitis in childhood","authors":"Rebecca Büttner , Melanie Schwermer , Thomas Ostermann , Alfred Längler , Tycho Zuzak","doi":"10.1016/j.ctim.2024.103031","DOIUrl":"10.1016/j.ctim.2024.103031","url":null,"abstract":"<div><h3>Background</h3><p>Medical guidelines are an important basis for qualitative and cost-effective patient care. However, there is a lack of clinical recommendations in anthroposophic medicine (AM), an integrative medicine approach frequently practised in Europe. Acute tonsillitis, which includes tonsillopharyngitis, is a common childhood disease. that is mostly caused by a viral infection. Symptomatic treatment is therefore of high importance, and AM can offer several therapy options.</p></div><div><h3>Methods</h3><p>53 physicians from Germany, Spain, Netherlands, Switzerland, Austria, and Hungary with at least one year of experience in anthroposophic paediatric medicine were invited to participate in an online Delphi process. The process comprises five survey rounds starting with open-ended questions and ending with final statements, which need 75% agreement of experts to reach consensus. Expert answers were evaluated by two independent reviewers using MAXQDA and Excel.</p></div><div><h3>Results</h3><p>Response rate was between 28% and 45%. The developed recommendation included 15 subtopics. These covered clinical, diagnostic, therapeutic and psychosocial aspects of acute tonsillitis. Six subtopics achieved a high consensus <em>(>90%)</em> and nine subtopics achieved consensus (<em>75–90%</em>).</p></div><div><h3>Conclusion</h3><p>The clinical recommendation for acute tonsillitis in children aims to simplify everyday patient care and provide decision-making support when considering and prescribing anthroposophic therapies. Moreover, the recommendation makes AM more transparent for physicians, parents, and maybe political stakeholders as well.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000190/pdfft?md5=d9c19f9d36372ed3d66a2067a5882e49&pid=1-s2.0-S0965229924000190-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23DOI: 10.1016/j.ctim.2024.103029
Tong Wu , Luolin Zhou , Xinru Liao , Yuewen He , Ronglin Xu , Daihong Luo
Background
Hypertension is a prevalent condition with significant impacts on human health. Chinese herbal foot bath, a traditional Chinese medicine treatment, is believed to help manage hypertension.
Objective
This systematic review aims to assess the efficacy of combining Chinese herbal foot bath with conventional treatment for hypertension.
Methods
A thorough search across eight databases was conducted to identify relevant studies on Chinese herbal foot bath for hypertension. Randomized controlled trials examining the benefits and risks of using Chinese herbal foot bath combined with conventional treatment for hypertension were included. Blood pressure changes before and after the Chinese herbal foot bath were assessed, and outcomes were analyzed using Review Manager 5.3 software. The certainty of evidence was evaluated using the GRADE tool.
Results
Compared to conventional treatment, Chinese herbal foot bath combined with conventional treatment demonstrated greater effectiveness in reducing systolic blood pressure (MD 6.69, 95% CI: 5.86 to 7.53, p < 0.00001) and diastolic blood pressure (MD 5.83, 95% CI: 5.23 to 6.43, p < 0.00001), which reported fewer adverse effects.These studies commonly present issues such as inadequate randomization, lack of blinding, and absence of independent testing for the purity or potency of herbs.
Conclusion
The meta-analysis suggests that Chinese herbal foot bath combined with conventional treatment may effectively manage hypertension, with few adverse effects. However, high-quality clinical trials are still needed to confirm these findings due to methodological weaknesses in randomization, blinding, long-term follow-up, and independent testing for the purity and potency of herbs.
{"title":"Efficacy and safety of chinese herbal foot bath for hypertension: A systematic review and meta-analysis","authors":"Tong Wu , Luolin Zhou , Xinru Liao , Yuewen He , Ronglin Xu , Daihong Luo","doi":"10.1016/j.ctim.2024.103029","DOIUrl":"10.1016/j.ctim.2024.103029","url":null,"abstract":"<div><h3>Background</h3><p>Hypertension is a prevalent condition with significant impacts on human health. Chinese herbal foot bath, a traditional Chinese medicine treatment, is believed to help manage hypertension.</p></div><div><h3>Objective</h3><p>This systematic review aims to assess the efficacy of combining Chinese herbal foot bath with conventional treatment for hypertension.</p></div><div><h3>Methods</h3><p>A thorough search across eight databases was conducted to identify relevant studies on Chinese herbal foot bath for hypertension. Randomized controlled trials examining the benefits and risks of using Chinese herbal foot bath combined with conventional treatment for hypertension were included. Blood pressure changes before and after the Chinese herbal foot bath were assessed, and outcomes were analyzed using Review Manager 5.3 software. The certainty of evidence was evaluated using the GRADE tool.</p></div><div><h3>Results</h3><p>Compared to conventional treatment, Chinese herbal foot bath combined with conventional treatment demonstrated greater effectiveness in reducing systolic blood pressure (MD 6.69, 95% CI: 5.86 to 7.53, p < 0.00001) and diastolic blood pressure (MD 5.83, 95% CI: 5.23 to 6.43, p < 0.00001), which reported fewer adverse effects.These studies commonly present issues such as inadequate randomization, lack of blinding, and absence of independent testing for the purity or potency of herbs.</p></div><div><h3>Conclusion</h3><p>The meta-analysis suggests that Chinese herbal foot bath combined with conventional treatment may effectively manage hypertension, with few adverse effects. However, high-quality clinical trials are still needed to confirm these findings due to methodological weaknesses in randomization, blinding, long-term follow-up, and independent testing for the purity and potency of herbs.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000177/pdfft?md5=ae4993240fd816716634bf9596899586&pid=1-s2.0-S0965229924000177-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139943982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号