Clinical Neurophysiology最新文献_第10页

Minimal social co-presence modulates heartbeat evoked potentials and EEG dynamics during a parallel crafting task 在并行制作任务中，最小的社会共同存在调节心跳诱发电位和脑电图动态。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-11-05 DOI: 10.1016/j.clinph.2025.2111414

Junya Orui , Keigo Shiraiwa , Fumie Tazaki , Masaya Ueda , Keita Ueno , Yasuo Naito , Ryouhei Ishii

Objective

To investigate the neurophysiological effects of minimal social co-presence on the Heartbeat Evoked Potential (HEP) and EEG dynamics, providing a normative baseline for altered interoception in clinical disorders.

Methods

Thirty healthy adults performed a repetitive crafting task in “alone” and “parallel social presence” conditions. EEG and ECG were recorded, and HEPs plus time–frequency dynamics were compared using permutation testing. Changes in cardiac vagal activity and subjective stress were also assessed.

Results

Parallel co-presence significantly altered HEP morphology (reduced frontal negativity, central-parietal positivity) and EEG power (beta, theta, alpha bands). Only under parallel condition, frontal HEP amplitude correlated with increased cardiac vagal activity (r = 0.39) and reduced subjective stress (rS = -0.55).

Conclusion

Minimal social context alters the brain’s processing of cardiac signals and its autonomic relationship in healthy young adults, establishing a neurophysiological benchmark for brain-body-society interactions. As this study used a non-clinical sample, the findings are not direct evidence of HEP’s clinical utility. This work provides a foundational baseline for future comparative studies needed to determine its potential as a clinical biomarker.

Significance

This study is the first to demonstrate normative neurophysiological effects of minimal social presence on HEP, providing critical evidence and guidance for future clinical research.

目的：探讨最小社会共存在对心电诱发电位（HEP）和脑电图动态的神经生理影响，为临床障碍中内感受的改变提供规范的基线。方法：30名健康成人在“单独”和“平行社会存在”条件下进行重复性制作任务。记录脑电图和心电图，采用排列试验比较HEPs和时频动态。还评估了心脏迷走神经活动和主观应激的变化。结果：平行共存显著改变了HEP形态学（额叶负性、中央-顶叶正性减弱）和脑电图功率（β、θ、α波段）。只有在平行条件下，额部HEP振幅与心脏迷走神经活动增加（r = 0.39）和主观应激减少（r = -0.55）相关。结论：最小的社会环境改变了健康年轻人大脑对心脏信号的处理及其自主关系，为脑-体-社会相互作用建立了神经生理学基准。由于本研究使用的是非临床样本，因此研究结果并不是HEP临床应用的直接证据。这项工作为未来的比较研究奠定了基础，以确定其作为临床生物标志物的潜力。意义：本研究首次证明了最小社会存在对HEP的规范性神经生理影响，为今后的临床研究提供了重要的证据和指导。

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引用次数: 0

Temporal dynamics of electroconvulsive therapy induced seizures 电痉挛疗法诱发癫痫发作的时间动力学。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-11-12 DOI: 10.1016/j.clinph.2025.2111439

Sven Stuiver , Prejaas K.B. Tewarie , Julia C.M. Pottkämper , Joey P.A.J. Verdijk , Michel J.A.M. van Putten , Jeannette Hofmeijer , Jeroen A. van Waarde

Objective

Electroconvulsive therapy (ECT) is an effective treatment for several psychiatric disorders. The role of cortex and thalamus in seizure expression and termination seems critical. Here we study spatiotemporal dynamics of ECT-induced seizures based on electroencephalogram (EEG) features and biophysical parameters using a corticothalamic mean-field model.

Methods

We analyzed 345 ictal EEGs from 33 patients (19 female). EEG features included the dominant frequency, and temporal and spatial correlations. A corticothalamic biophysical model assessed cortical excitation/inhibition (E/I) balance and effective corticothalamic and intrathalamic loop strengths. We tracked the temporal evolution of each feature and parameter from seizure onset to termination.

Results

ECT-induced seizures showed EEG slowing (i.e., a decrease in dominant frequency) and increased temporal correlations as seizures approached termination. Cortical E/I ratios and corticothalamic loop strength increased, while intrathalamic strength decreased. Both EEG slowing and increase in temporal correlations were associated with increased cortical E/I ratios and decreased intrathalamic loop strength.

Conclusions

ECT-induced seizures show slowing and increased temporal correlations toward termination. These dynamics may be driven by increased cortical E/I ratios and decreased intrathalamic loop strength.

Significance

ECT-induced seizures exhibit characteristic temporal corticothalamic dynamics.

目的：电休克治疗是治疗多种精神疾病的有效方法。皮层和丘脑在癫痫表达和终止中的作用似乎至关重要。本研究采用皮质丘脑平均场模型，基于脑电图特征和生物物理参数研究ect诱发癫痫发作的时空动态。方法：对33例患者345例脑电图进行分析，其中女性19例。脑电特征包括主频率、时间和空间相关性。皮质丘脑生物物理模型评估皮质兴奋/抑制（E/I）平衡和有效的皮质丘脑和丘脑内环路强度。我们跟踪了每个特征和参数从发作到终止的时间演变。结果：随着癫痫发作接近终止，ect诱导的癫痫发作表现为脑电图减慢（即优势频率降低）和时间相关性增加。皮层E/I比值和皮质丘脑回路强度增加，而丘脑内强度降低。脑电图减慢和时间相关性增加都与皮层E/I比值增加和丘脑内环路强度下降有关。结论：ect诱发的癫痫发作表现出缓慢和增加的时间相关性。这些动态可能是由皮质E/I比率增加和丘脑内环路强度下降驱动的。意义：ect诱发的癫痫发作表现出特征性的颞皮质-丘脑动力学。

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引用次数: 0

Classic midline versus lateral scalp montages in lower limb somatosensory evoked potentials during intra-operative neuromonitoring 术中神经监测中下肢躯体感觉诱发电位的经典中线与外侧头皮蒙太奇。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-11-08 DOI: 10.1016/j.clinph.2025.2111428

Danilo E. Lopez-Garcia , Luis A. Marin-Castaneda , Huguette Heredia Martínez , Daniel Murra-Talamas , Fabiola M. López-Castellanos , Antonio de León , Gerson Ángel Alavez , Daniel San-Juan , Geronimo Pacheco-Aispuro

引用次数: 0

EEG in the critical care setting 脑电图在重症监护环境

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI: 10.1016/j.clinph.2025.2111431

Lawrence J. Hirsch , Margaret T. Gopaul

Continuous EEG (cEEG) is increasingly used in the intensive care unit (ICU), but implementation and interpretation remain variable. To better understand its clinical impact, this review evaluates its role in diagnosis, prognostication, and treatment. To do so, we conducted a narrative review of observational studies, randomized controlled trials, consensus recommendations, and illustrative cases across adult and pediatric critical care populations. In these studies, nonconvulsive seizures occur in ∼10–20 % of ICU patients undergoing cEEG, most without clinical signs, and risk is highest in coma, pediatrics, with prior clinical seizures (recent or remote), and acute structural brain injury. Seizure burden > 12 min/hour (20 % burden) qualifies as status epilepticus (SE). Furthermore, higher seizure burden consistently predicts poor outcomes, including hippocampal injury, functional and cognitive impairment, epilepsy, and increased mortality. Additionally, rapid-response EEG and AI-based tools improve diagnostic efficiency, expand access, and may improve outcomes and length of stay. Quantitative EEG can reliably detect other acute brain events, such as delayed cerebral ischemia after subarachnoid hemorrhage, usually sooner than any other practical method. In summary, cEEG has transformed seizure detection and outcome prediction in the ICU, though gaps persist in access, workforce capacity, interpretation, patient selection, and clinical implementation. Broader standardization, expansion of point-of-care rapid EEG devices, and AI integration are critical to scaling cEEG and improving patient outcomes.

连续脑电图（cEEG）越来越多地用于重症监护病房（ICU），但实施和解释仍然存在变数。为了更好地了解其临床影响，本综述评估了其在诊断、预后和治疗中的作用。为此，我们对观察性研究、随机对照试验、共识建议和成人和儿童重症监护人群的说明性病例进行了叙述性回顾。在这些研究中，非惊厥性癫痫发作发生在10 - 20%的ICU患者中，大多数没有临床症状，在昏迷、儿科、既往临床癫痫发作（近期或远期）和急性结构性脑损伤中风险最高。癫痫发作负担12分钟/小时（20%负担）为癫痫持续状态（SE）。此外，较高的癫痫发作负担始终预示着不良结果，包括海马损伤、功能和认知障碍、癫痫和死亡率增加。此外，快速反应脑电图和基于人工智能的工具提高了诊断效率，扩大了可及性，并可能改善结果和住院时间。定量脑电图可以可靠地检测到其他急性脑事件，如蛛网膜下腔出血后的延迟性脑缺血，通常比任何其他实用方法都要快。综上所述，脑电图已经改变了ICU的癫痫发作检测和结果预测，尽管在获取、劳动力能力、解释、患者选择和临床实施方面仍然存在差距。更广泛的标准化、医疗点快速脑电图设备的扩展和人工智能集成对于扩大脑电图和改善患者预后至关重要。

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引用次数: 0

Modulating altered sensory prediction using bilateral auditory cortex high-definition transcranial random noise stimulation and acoustic masking 利用双侧听觉皮层高清晰度经颅随机噪声刺激和声掩蔽调节改变的感觉预测。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-11-16 DOI: 10.1016/j.clinph.2025.2111388

Zino H. Wellauer , Deniza Avdi , Payam S. Shabestari , Allegra Preisig , Jessica Fritzsche , Nicole Peter , Martin Meyer , Tobias Kleinjung , Patrick K.A. Neff

Objective:

To assess the combined effect of high-definition transcranial random noise stimulation (HD-tRNS) of bilateral auditory cortex and acoustic stimulation (AS) on auditory evoked potentials and tinnitus perception.

Methods:

A double-blind, randomized, controlled, within-subject crossover trial was conducted with thirteen adults with chronic tinnitus. Each participant completed four sessions, at least 48 h apart, consisting of active HD-tRNS + AS, active HD-tRNS alone, sham HD-tRNS + sham AS and sham HD-tRNS alone. Auditory evoked potentials (including mismatch negativity) and tinnitus characteristics were measured before and after each session.

Results:

Active electric and bimodal stimulation significantly modulated auditory evoked potentials, unlike their sham equivalents. Bimodal stimulation produced significant changes in MMN amplitude that countered the tinnitus-related alteration in processing intensity deviants. However, these effects did not survive family-wise correction in this complex design. Bimodal and bimodal-sham stimulation reduced objective loudness by >3 dB.

Conclusion:

HD-tRNS, particularly when combined with AS, may induce changes in auditory-system excitability and acutely alter neural processing and loudness perception in tinnitus.

Significance:

Combining acoustic and electric stimulation is a promising approach for basic research and clinical applications in auditory neuroscience, providing new insights into neuroplasticity in an altered auditory system. This is the first study to measure the modifiability of evoked neural correlates in tinnitus.

目的：探讨双侧听觉皮层高清晰度经颅随机噪声刺激（HD-tRNS）和声刺激（AS）对听觉诱发电位和耳鸣感知的联合影响。方法：对13例成人慢性耳鸣患者进行双盲、随机、对照、组内交叉试验。每个参与者完成四个疗程，间隔至少48小时，包括活性HD-tRNS + AS、单独活性HD-tRNS、假HD-tRNS +假AS和单独假HD-tRNS。每次训练前后分别测量听觉诱发电位（包括错配负性）和耳鸣特征。结果：与假刺激不同，主动电刺激和双峰刺激显著调节了听觉诱发电位。双峰刺激产生了MMN振幅的显著变化，抵消了耳鸣相关的加工强度偏差的改变。然而，在这个复杂的设计中，这些影响并没有在家庭明智的纠正中幸存下来。双峰刺激和双峰-假刺激使客观响度降低bb30 dB。结论：HD-tRNS，特别是与AS合并时，可引起耳鸣患者听觉系统兴奋性的改变，并严重改变耳鸣患者的神经加工和响度感知。意义：声电结合刺激是听觉神经科学基础研究和临床应用的一种有前景的方法，为听觉系统改变中的神经可塑性提供了新的见解。这是第一个测量耳鸣中诱发神经相关物可变性的研究。

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引用次数: 0

Youth with essential tremor differ from age-matched controls in multiple aspects of visually-guided reaching movements 患有特发性震颤的青少年在视觉引导的伸手动作的多个方面与年龄匹配的对照组不同

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/j.clinph.2025.2111445

Nicholas Cothros , Catherine Lowrey , Stephen H. Scott , Alex Medina Escobar , Sean Dukelow , Davide Martino , Tamara Pringsheim

Objective

Essential tremor (ET) likely includes deficits outside tremor, though this is under-examined in youth. We tested the hypothesis that reaching movements in youth with ET are characterized by greater incoordination.

Methods

Fifteen youth with ET (ages 11 to 17) recruited from the Calgary Tourette and Pediatric Movement Disorders Clinic completed a visually-guided reaching task using the Kinarm Exoskeleton Lab. Performance in several kinematic parameters was compared with age-matched controls.

Results

Youth with ET differed from controls in multiple parameters. In the dominant arm, the initial portion of reaching movements was slower and smaller-amplitude, with longer reaction time and greater posture speed at movement end when the hand should be at rest. In the non-dominant arm, those with ET differed from controls in a larger number of parameters. All but three with ET were impaired in at least one task parameter, scoring outside age-predicted norms.

Conclusion

Our study supports the notion of ET as a disorder with abnormalities beyond tremor, and that motoric abnormalities are demonstrable in youth with ET.

Significance

This is the first study showing youth with ET differ from age-matched controls in multiple aspects of reaching movements, including initial trajectory control, movement smoothness, overall trajectory, and endpoint control.

目的特发性震颤（ET）可能包括震颤以外的缺陷，尽管这在青少年中尚未得到充分研究。我们测试了一个假设，即ET青少年的伸展运动的特点是更大的不协调。方法从卡尔加里抽动秽语和儿童运动障碍诊所招募了15名ET青少年（11至17岁），使用Kinarm外骨骼实验室完成了一项视觉引导的到达任务。将几个运动学参数的表现与年龄匹配的对照组进行比较。结果ET患儿与对照组在多个参数上存在差异。优势臂到达动作的起始部分速度较慢，幅度较小，动作结束时反应时间较长，动作结束时姿态速度较大。在非优势组中，ET患者在许多参数上与对照组不同。除了三个外，所有ET患者在至少一个任务参数上都受损，得分超出了年龄预测标准。结论：我们的研究支持ET是一种除震颤外的异常疾病的观点，并且运动异常在ET的青少年中是明显的。意义：这是第一个研究表明ET的青少年在到达运动的多个方面与年龄匹配的对照组不同，包括初始轨迹控制、运动平滑度、总体轨迹和终点控制。

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引用次数: 0

Effect of resting motor threshold availability on preoperative motor cortex localization using navigated-TMS in glioma surgery 脑胶质瘤手术中静息运动阈值可用性对术前运动皮质定位的影响。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-11-09 DOI: 10.1016/j.clinph.2025.2111429

Buntou Ro , Manabu Tamura , Atsushi Kuwano , Tomokazu Takakura , Sachiko Kodera , Akimasa Hirata , Takakazu Kawamata , Ken Masamune , Yoshihiro Muragaki

Objective

To assess the concordance between preoperative motor cortex mapping using navigated transcranial magnetic stimulation (nTMS) and intraoperative direct electrical stimulation (DES), and to determine whether the ability to obtain the resting motor threshold (RMT) affects mapping accuracy.

Methods

Seventeen patients with motor or premotor cortical gliomas underwent preoperative nTMS and intraoperative DES. Motor mapping was performed using the RMT or, if unobtainable, the active motor threshold (AMT). Concordance between nTMS and DES was analyzed using Fisher’s exact test.

Results

Spatial concordance between nTMS and DES was observed in 9 of 12 patients (75 %) with measurable RMT. None of the five AMT-only cases demonstrated concordance. The difference in concordance rates between RMT and AMT-only cases was statistically significant (p = 0.026). Representative cases illustrate the relationship between RMT availability and mapping accuracy.

Conclusions

Preoperative nTMS mapping showed high concordance with DES when the RMT was obtainable. The lack of an RMT may predict reduced intraoperative mapping reliability.

Significance

RMT preoperative assessment can guide surgical planning, including the need for subcortical mapping or adjusted resection margins. These findings highlight the utility of nTMS for motor localization and emphasize the value of the RMT for predicting intraoperative mapping success.

目的：评估术前经颅磁刺激（nTMS）和术中直接电刺激（DES）运动皮质映射的一致性，并确定获得静息运动阈值（RMT）的能力是否影响映射精度。方法：17例运动或运动前皮质胶质瘤患者术前接受nTMS和术中DES。运动映射使用RMT，如果无法获得，则使用活动运动阈值（AMT）。采用Fisher精确检验分析nTMS与DES的一致性。结果：在12例可测量RMT的患者中，有9例（75%）观察到nTMS和DES的空间一致性。5例仅amt的病例均未显示一致性。RMT与amt的一致性率差异有统计学意义（p = 0.026）。代表性的案例说明了RMT可用性和映射准确性之间的关系。结论：术前行RMT时，nTMS图谱与DES高度一致。缺乏RMT可能预示术中测图可靠性降低。意义：RMT术前评估可以指导手术计划，包括需要皮质下作图或调整切除边缘。这些发现强调了nTMS在运动定位中的应用，并强调了RMT在预测术中定位成功方面的价值。

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引用次数: 0

Fiber recruitment in intra-epidermal electrical stimulation: Assessing the likelihood of Aδ- and Aβ-fiber activation 表皮内电刺激中的纤维募集：评估Aδ-和a β-纤维激活的可能性

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-11-05 DOI: 10.1016/j.clinph.2025.2111415

Sara U. Júlio , Jana Vaterlaus , Robin Lütolf , Markus Kofler , Michèle Hubli , Martin Schubert

Objective

To compare intra-epidermal (IES) and transcutaneous (TES) electrical stimulation with regard to nociceptive Aδ-fiber activation and Aβ-fiber co-activation. Cutaneous silent periods (CSPs) were assessed as a proxy for Aδ-fiber activation, and cortical vertex potentials (VPs) in the absence of somatosensory evoked cortical potentials (SSEPs) were assessed to exclude Aβ-fiber activation.

Methods

IES and TES were applied at increasing intensities (multiples of electrical detection threshold, EDT). In Experiment 1, psychophysical assessments, i.e., pain intensity and quality, and CSPs were compared for IES and TES at the index finger in 29 participants (10 m, 26.6 ± 3.5 years). In Experiment 2, SSEPs and VPs were compared for IES and TES over the superficial radial nerve in 28 participants (11 m, 26.6 ± 3.4 years).

Results

IES, irrespective of stimulation intensity, was mainly perceived as noxious and significantly more painful than TES (p < 0.001). Significant EMG suppression (p = 0.002) indicated robust CSPs following IES, suggesting efficient Aδ-fiber activation compared to TES at 4x EDT. Moreover, SSEPs were absent in response to IES at 4x EDT, suggesting low Aβ-fiber co-activation, while VPs were consistently detected.

Conclusions

IES at 4x EDT produces efficient Aδ-fiber activation with minimal Aβ-fiber co-activation, accompanied by consistently detected VPs.

Significance

IES at 4x EDT is suggested for efficient electrical nociceptive testing.

目的比较表皮内电刺激（IES）和经皮电刺激（TES）对痛觉性a δ-纤维激活和a β-纤维共激活的影响。评估皮肤沉默期（CSPs）作为a - β纤维激活的替代指标，评估体感诱发皮层电位（ssep）缺失时的皮质顶点电位（vp）以排除a - β纤维激活。方法以增加的强度（电检测阈值的倍数，EDT）应用sies和TES。在实验1中，比较29名参与者（10 m, 26.6±3.5岁）的IES和TES在食指的心理物理评估，即疼痛强度和质量，以及csp。实验2比较28例（11 m, 26.6±3.4岁）患者桡浅神经上IES和TES的ssep和VPs。结果，无论刺激强度如何，主要被认为是有害的，明显比TES更痛苦（p < 0.001）。显著的肌电抑制（p = 0.002）表明，IES后csp强健，表明在4倍EDT时，与TES相比，a - δ纤维激活更有效。此外，在4倍EDT时，ssep对IES的反应缺失，表明a β-纤维共激活较低，而VPs一直被检测到。结论在4倍EDT下，a - δ-纤维有效活化，a - β-纤维协同活化最小，并伴有持续检测到的VPs。建议在4倍EDT时进行有效的电伤害性测试。

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引用次数: 0

Cerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3: An electric field modelling study 经颅直流电刺激治疗脊髓小脑共济失调3型：电场模拟研究。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-10-26 DOI: 10.1016/j.clinph.2025.2111405

Roderick P.P.W.M. Maas , ESMI MR Study Group , Jennifer Faber , Bart P.C. van de Warrenburg , Dennis J.L.G. Schutter

Objectives

To compare cerebellar transcranial direct current stimulation (tDCS)-induced electric field strengths between individuals with spinocerebellar ataxia type 3 (SCA3) and healthy controls and to identify factors that underlie the variability in field strength.

Methods

MRI scans from 68 SCA3 mutation carriers spanning the disease spectrum and 37 healthy adults were used to reconstruct tetrahedral volume meshes of the head. Electric field simulations of midline cerebellar tDCS were performed with the buccinator muscle, frontopolar region, and lower neck as reference electrode positions. Eight regions of interest were defined throughout the cerebellum.

Results

Simulated electric field strengths induced by cerebellar tDCS were generally lower in SCA3 mutation carriers than in healthy controls, particularly in the anterior lobe and with cephalic reference electrodes. The frontopolar montage induced the highest field strengths, while the lower neck montage caused the lowest field strengths. Skin-cerebellum distance, Scale for the Assessment and Rating of Ataxia (SARA) score, and “occipital angle” were independently associated with electric field strength.

Conclusion

Skin-cerebellum distance, posterior fossa morphometry, ataxia severity, and electrode montage predict cerebellar tDCS-induced electric field strength in SCA3 mutation carriers. These results may guide the development of personalized neuromodulation protocols and inform the design of future cerebellar tDCS trials in degenerative ataxias.

Significance

This study identified clinical and anatomical factors that affect cerebellar tDCS-induced field strength in individuals with the most common type of dominantly inherited ataxia worldwide.

目的：比较脊髓小脑性失调3型（SCA3）患者与健康对照者的经颅直流电刺激（tDCS）诱发的电场强度，并确定电场强度差异的因素。方法：对68例SCA3突变携带者和37例健康成人进行MRI扫描，重建头部四面体体积网格。以颊肌、额极区和下颈部为参比电极位置，对小脑中线tDCS进行电场模拟。在整个小脑中确定了八个感兴趣的区域。结果：SCA3突变携带者的小脑tDCS诱导的模拟电场强度普遍低于健康对照组，尤其是在前叶和使用头侧参考电极的人群中。顶极蒙太奇诱导的场强最高，下颈蒙太奇诱导的场强最低。皮肤-小脑距离、共济失调评定量表（SARA）评分和“枕角”与电场强度独立相关。结论：皮肤-小脑距离、后窝形态、共济失调严重程度和电极蒙太奇可预测SCA3突变携带者tdcs诱导的小脑电场强度。这些结果可能指导个性化神经调节方案的发展，并为未来退行性共济失调小脑tDCS试验的设计提供信息。意义：本研究确定了影响世界上最常见的显性遗传性共济失调患者tdcs诱导的小脑电场强度的临床和解剖学因素。

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引用次数: 0

Does the ability to stop ongoing movement differentiate cervical dystonia from functional cervical dystonia? 停止正在进行的运动的能力能否区分颈张力障碍和功能性颈张力障碍？

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-11-04 DOI: 10.1016/j.clinph.2025.2111417

Sattwika Banerjee , Supriyo Choudhury , Asit Baran Bayen , Suchismita Majumdar , Akash Roy , Praveen Kumar , Souvik Chakroborty , Soumava Mukherjee , Jacky Ganguly , Purba Basu , Mark R Baker , Stuart N Baker , Hrishikesh Kumar

Objective

Functional Cervical Dystonia (FCD) is characterized by hyperkinetic movements resembling Cervical Dystonia (CD). Previous studies report impaired reactive inhibition in CD, reflected by prolonged optimum combination Stop Signal Reaction Time (ocSSRT). This study compared ocSSRT in FCD, CD, and healthy controls.

Methods

20 CD and 14 FCD patients were recruited along with 23 age-matched healthy controls. All participants used a battery-operated portable device that measured both median reaction time and ocSSRT. Subjects released a button following a GO (green) signal and attempted to abort the movement when a STOP (red) signal followed the GO cue after a short delay.

Results

CD patients had significantly prolonged ocSSRT compared to FCD and healthy controls (CD: 373 ± 76 ms, FCD: 285 ± 80 ms, healthy: 248 ± 64 ms; CD vs FCD, p = 0.026; CD vs healthy, p < 0.001). No significant difference was found between FCD and healthy controls (p = 0.396). Median reaction time was significantly longer in CD (563 ± 117 ms) than healthy controls (466 ± 82 ms; p = 0.015), but not FCD (500 ± 117 ms; p = 0.296). The ROC curve AUC for ocSSRT distinguishing CD from FCD was 0.775 (p = 0.002).

Conclusion and Significance

ocSSRT may serve as a useful marker to differentiate CD from FCD in clinical settings.

目的：功能性颈肌张力障碍（FCD）的特征是类似于颈肌张力障碍（CD）的过度运动。先前的研究报告了CD的反应性抑制受损，反映在最佳组合停止信号反应时间（ocSSRT）延长。本研究比较了FCD、CD和健康对照的ocSSRT。方法：招募20例乳糜泻患者和14例乳糜泻患者以及23例年龄匹配的健康对照者。所有参与者都使用了一个电池供电的便携式设备来测量中位反应时间和ocSSRT。受试者在绿灯信号发出后释放按钮，并在短暂延迟后红灯信号发出后试图中止动作。结果：与FCD和健康对照相比，CD患者的ocSSRT时间明显延长（CD: 373±76 ms, FCD: 285±80 ms，健康对照：248±64 ms； CD vs FCD, p = 0.026； CD vs健康对照，p）。结论及意义：ocSSRT可作为临床区分CD和FCD的有效标志物。

{"title":"Does the ability to stop ongoing movement differentiate cervical dystonia from functional cervical dystonia?","authors":"Sattwika Banerjee , Supriyo Choudhury , Asit Baran Bayen , Suchismita Majumdar , Akash Roy , Praveen Kumar , Souvik Chakroborty , Soumava Mukherjee , Jacky Ganguly , Purba Basu , Mark R Baker , Stuart N Baker , Hrishikesh Kumar","doi":"10.1016/j.clinph.2025.2111417","DOIUrl":"10.1016/j.clinph.2025.2111417","url":null,"abstract":"<div><h3>Objective</h3><div>Functional Cervical Dystonia (FCD) is characterized by hyperkinetic movements resembling Cervical Dystonia (CD). Previous studies report impaired reactive inhibition in CD, reflected by prolonged optimum combination Stop Signal Reaction Time (ocSSRT). This study compared ocSSRT in FCD, CD, and healthy controls.</div></div><div><h3>Methods</h3><div>20 CD and 14 FCD patients were recruited along with 23 age-matched healthy controls. All participants used a battery-operated portable device that measured both median reaction time and ocSSRT. Subjects released a button following a GO (green) signal and attempted to abort the movement when a STOP (red) signal followed the GO cue after a short delay.</div></div><div><h3>Results</h3><div>CD patients had significantly prolonged ocSSRT compared to FCD and healthy controls (CD: 373 ± 76 ms, FCD: 285 ± 80 ms, healthy: 248 ± 64 ms; CD vs FCD, p = 0.026; CD vs healthy, p < 0.001). No significant difference was found between FCD and healthy controls (p = 0.396). Median reaction time was significantly longer in CD (563 ± 117 ms) than healthy controls (466 ± 82 ms; p = 0.015), but not FCD (500 ± 117 ms; p = 0.296). The ROC curve AUC for ocSSRT distinguishing CD from FCD was 0.775 (p = 0.002).</div></div><div><h3>Conclusion and Significance</h3><div>ocSSRT may serve as a useful marker to differentiate CD from FCD in clinical settings.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111417"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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