Clinical Neurophysiology最新文献_第10页

Short-latency afferent inhibition and modulation of contralateral and ipsilateral motor output: A neurophysiological study 对侧和同侧运动输出的短潜伏期传入抑制和调节：一项神经生理学研究。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-26 DOI: 10.1016/j.clinph.2025.2111397

Francesco Motolese , Antonio Todisco , Licia Maria Celani , Gabriella Musumeci , Alessandro Cruciani , Davide Norata , Francesca Santoro , Mariagrazia Rossi , Fabio Pilato , Fioravante Capone , Vincenzo Di Lazzaro

Objective

Sensorimotor integration involves processing sensory input to modulate motor output through cortical-subcortical interactions. Short-latency afferent inhibition (SAI), a transcranial magnetic stimulation (TMS) protocol, is widely used to investigate this phenomenon. In this study, we investigated sensorimotor integration by assessing SAI using both contralateral (conventional protocol) and ipsilateral (experimental protocol) peripheral electrical stimulation, including interstimulus intervals (ISIs) preceding the cortical response of somatosensory evoked potentials (N20).

Methods

Twenty-four healthy participants underwent TMS over the primary motor cortex (M1), paired with either ipsilateral or contralateral median nerve stimulation at various ISIs relative to individual N20 latencies (–2 ms, –1 ms, +2 ms, +3 ms, +4 ms). Both hemispheres and stimulation conditions (ipsilateral, contralateral) were tested.

Results

Significant MEP amplitude reduction occurred with contralateral stimulation at ISIs preceding (only dominant hemisphere) and following the N20 response (both hemispheres). Ipsilateral stimulation did not modulate motor output at any ISI.

Conclusion

Our results confirm that SAI is a strictly lateralized phenomenon, occurring exclusively with contralateral peripheral stimulation and elicitable at intervals preceding the N20 response, but limited to the dominant hemisphere.

Significance

These findings emphasize the pivotal role of contralateral thalamo-cortical circuits in sensorimotor integration and provide deeper insights into the mechanisms underlying the short-latency afferent inhibition (SAI) phenomenon.

目的：感觉运动整合是指通过皮层-皮层下相互作用对感觉输入进行加工以调节运动输出。短潜伏期传入抑制（SAI）是一种经颅磁刺激（TMS）方案，被广泛用于研究这一现象。在这项研究中，我们通过对侧（常规方案）和同侧（实验方案）外周电刺激评估SAI来研究感觉运动整合，包括在躯体感觉诱发电位（N20）皮层反应之前的刺激间期（ISIs）。方法：24名健康参与者在初级运动皮层（M1）上接受经颅磁刺激，并在相对于个体N20潜伏期（-2 ms, -1 ms, +2 ms, +3 ms, +4 ms）的不同ISIs下对同侧或对侧正中神经进行刺激。测试了两个半球和刺激条件（同侧，对侧）。结果：在N20反应之前（仅占主导半球）和之后（两个半球），对侧刺激在ISIs发生显著的MEP振幅降低。同侧刺激没有调节任何ISI的运动输出。结论：我们的研究结果证实，SAI是一种严格的侧化现象，只发生在对侧外周刺激下，在N20反应之前的间隔时间内可引起，但仅限于优势半球。意义：这些发现强调了对侧丘脑-皮层回路在感觉运动整合中的关键作用，并为短潜伏期传入抑制（SAI）现象的机制提供了更深入的见解。

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引用次数: 0

EEG variability in inflammatory encephalopathy: Dissemination in time and space 炎症性脑病的脑电图变异性：时间和空间的传播。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-26 DOI: 10.1016/j.clinph.2025.2111402

Enrico Binaghi , Nora Schwab , Francesco Capecchi , David Weller , Stephan Neidhart , Christian R Baumann , Michael Weller , Ilijas Jelcic , Lukas Imbach

Objective

To assess the diagnostic value of repeated EEG in differentiating autoimmune encephalitis (AE) from herpes simplex virus-associated viral encephalitis (HSVE).

Methods

This observational case-control study analyzed 269 EEGs from 35 AE, 26 HSVE patients and two control groups with temporal lobe epilepsy (TLE) and acute non-inflammatory encephalopathy (ENC). We examined time- and space-related EEG changes in focal slowing (FS), epileptiform discharges (ED), and seizures. A five-item EEG variability score was calculated for each patient.

Results

Patients with AE showed greater spatial variability in FS (46.4 % vs. 28.9 %, p < 0.001) and higher variability in FS severity (44.3 % vs. 34.6 %, p < 0.05) than patients with HSVE. Bilateral FS was more frequent in AE (67.7 % vs. 41.7 %, p = 0.05).

AE demonstrated also higher ED location variability (37.5 % vs. 29.87 %, p = 0.058), and more bilateral ED (40 % vs. 23.5 %, p = 0.73). The EEG variability score was higher in patients with AE (2.34) than HSVE (1.43, p < 0.05) or in patients with TLE (1.17, p < 0.005) and acute encephalopathy (0.63, p < 0.001).

Conclusion

AE is characterized by greater temporal and spatial EEG variability than HSVE.

Significance

EEG variability is a consistent feature mainly seen in AE and may offer additional insights for differential diagnosis.

目的：探讨反复脑电图对自身免疫性脑炎（AE）与单纯疱疹病毒相关病毒性脑炎（HSVE）的鉴别诊断价值。方法：本观察性病例对照研究分析了35例AE患者、26例HSVE患者和2个颞叶癫痫（TLE）和急性非炎症性脑病（ENC）对照组的269例脑电图。我们检查了局灶性慢化（FS）、癫痫样放电（ED）和癫痫发作的时间和空间相关脑电图变化。计算每位患者的五项EEG变异性评分。结果：AE患者在FS表现出更大的空间变异性（46.4% vs. 28.9%）。结论：AE比HSVE具有更大的时间和空间EEG变异性。意义：脑电图变异性是主要见于AE的一致特征，可能为鉴别诊断提供额外的见解。

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引用次数: 0

Cerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3: An electric field modelling study 经颅直流电刺激治疗脊髓小脑共济失调3型：电场模拟研究。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-26 DOI: 10.1016/j.clinph.2025.2111405

Roderick P.P.W.M. Maas , ESMI MR Study Group , Jennifer Faber , Bart P.C. van de Warrenburg , Dennis J.L.G. Schutter

Objectives

To compare cerebellar transcranial direct current stimulation (tDCS)-induced electric field strengths between individuals with spinocerebellar ataxia type 3 (SCA3) and healthy controls and to identify factors that underlie the variability in field strength.

Methods

MRI scans from 68 SCA3 mutation carriers spanning the disease spectrum and 37 healthy adults were used to reconstruct tetrahedral volume meshes of the head. Electric field simulations of midline cerebellar tDCS were performed with the buccinator muscle, frontopolar region, and lower neck as reference electrode positions. Eight regions of interest were defined throughout the cerebellum.

Results

Simulated electric field strengths induced by cerebellar tDCS were generally lower in SCA3 mutation carriers than in healthy controls, particularly in the anterior lobe and with cephalic reference electrodes. The frontopolar montage induced the highest field strengths, while the lower neck montage caused the lowest field strengths. Skin-cerebellum distance, Scale for the Assessment and Rating of Ataxia (SARA) score, and “occipital angle” were independently associated with electric field strength.

Conclusion

Skin-cerebellum distance, posterior fossa morphometry, ataxia severity, and electrode montage predict cerebellar tDCS-induced electric field strength in SCA3 mutation carriers. These results may guide the development of personalized neuromodulation protocols and inform the design of future cerebellar tDCS trials in degenerative ataxias.

Significance

This study identified clinical and anatomical factors that affect cerebellar tDCS-induced field strength in individuals with the most common type of dominantly inherited ataxia worldwide.

目的：比较脊髓小脑性失调3型（SCA3）患者与健康对照者的经颅直流电刺激（tDCS）诱发的电场强度，并确定电场强度差异的因素。方法：对68例SCA3突变携带者和37例健康成人进行MRI扫描，重建头部四面体体积网格。以颊肌、额极区和下颈部为参比电极位置，对小脑中线tDCS进行电场模拟。在整个小脑中确定了八个感兴趣的区域。结果：SCA3突变携带者的小脑tDCS诱导的模拟电场强度普遍低于健康对照组，尤其是在前叶和使用头侧参考电极的人群中。顶极蒙太奇诱导的场强最高，下颈蒙太奇诱导的场强最低。皮肤-小脑距离、共济失调评定量表（SARA）评分和“枕角”与电场强度独立相关。结论：皮肤-小脑距离、后窝形态、共济失调严重程度和电极蒙太奇可预测SCA3突变携带者tdcs诱导的小脑电场强度。这些结果可能指导个性化神经调节方案的发展，并为未来退行性共济失调小脑tDCS试验的设计提供信息。意义：本研究确定了影响世界上最常见的显性遗传性共济失调患者tdcs诱导的小脑电场强度的临床和解剖学因素。

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引用次数: 0

Somatotopic sensory trigeminal rootlets identification via unmasked trigemino-facial reflexes. Insights from trigeminal nerve surgery 通过揭露三叉神经-面部反射识别体位感觉三叉神经根。三叉神经手术的启示

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-25 DOI: 10.1016/j.clinph.2025.2111404

Marc Sindou , Joseph Maarrawi

Objectives

Among the brainstem reflexes, the well-known blink reflex is commonly used to assess pathologies involving the trigeminal and/or facial nerves and to enhance surgical safety through monitoring.

Taking advantage of percutaneous access to the trigeminal root during radio-frequency thermo-rhizotomies for trigeminal neuralgia, sensory rootlets corresponding to the trigger zone were identified by electrical stimulation prior to lesioning. During stimulation, we observed evoked motor responses (EMRs) not only in the orbicularis oculi but also in lower facial muscles—an observation not previously reported, to our knowledge.

Methods

Stimulation at 5 Hz was used to evoke paresthesias in the patient’s face. Concurrently, EMRs were observed in the orbicularis oculi or, independently, in the levator labii or orbicularis oris muscles, depending on electrode position within the targeted sensory rootlets.

Results

EMRs were clinically observed in 44.2 % of 459 procedures when the electrode contacted closely targeted rootlets.

A positive correlation was found between EMR topography (orbicularis oculi, levator labii, orbicularis oris) and trigeminal territories (V1, V2, V3) in 95 % and 96 % of procedures for evoked paresthesias and post-thermolesion hypoesthesia, respectively.

Conclusions

EMRs topography, when observable, accurately predicts trigeminal territories.

Significance

Those EMRs interpreted as trigemino-facial reflexes (TFRs) may serve as a useful tool for identifying retrogasserian sensory fibers.

目的在脑干反射中，众所周知的眨眼反射常用于评估涉及三叉神经和/或面神经的病变，并通过监测提高手术安全性。利用射频热根切断术治疗三叉神经痛时经皮进入三叉神经根的优势，在损伤前通过电刺激识别与触发区相对应的感觉根。在刺激过程中，我们不仅在眼轮匝肌中观察到诱发运动反应（EMRs），而且在面部下部肌肉中也观察到——据我们所知，这一观察结果以前没有报道过。方法采用5hz电刺激引起患者面部感觉异常。同时，根据电极在目标感觉根内的位置，在眼轮匝肌或独立的提唇肌或口轮匝肌中观察到emr。结果在459例手术中，44.2%的患者在电极与靶根紧密接触时观察到磁共振成像。EMR地形（眼轮匝肌、提唇肌、口轮匝肌）和三叉神经区域（V1、V2、V3）在95%和96%的诱发性感觉异常和热消融后感觉减退的手术中分别呈正相关。结论磁共振地形图可准确预测三叉神经区域。意义：这些被解释为三叉神经-面部反射（TFRs）的emr可以作为识别后神经感觉纤维的有用工具。

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引用次数: 0

Ipsilateral and contralateral cortical control of the external oblique muscles revealed by TMS 经颅磁刺激揭示的外斜肌同侧和对侧皮质控制

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-24 DOI: 10.1016/j.clinph.2025.2111400

Ryoji Miyano , Yuichiro Shirota , Satoshi Kodama , Tatsushi Toda , Masashi Hamada

Objectives

Transcranial magnetic stimulation (TMS) is used widely to explore human motor function. This study was conducted to investigate the differences between contralateral and ipsilateral cortical control on trunk muscles for eliciting contralateral and ipsilateral motor evoked potentials (MEPs) in the external oblique muscles.

Methods

Twenty healthy participants were examined: 10 younger and 10 older adults. They underwent TMS to locate contralateral and ipsilateral hot spots. For the identified hot spots in the younger group, the coil was positioned in eight orientations, each separated by 45 degrees, to measure active motor threshold (AMT) and onset latencies.

Results

Contralateral MEPs were obtained from all participants, whereas ipsilateral MEPs were detected in 14 out of 20 participants. The ipsilateral hot spots were located more laterally from Cz (p < 0.05). Coil orientation that induced an antero-medially directed current in the brain produced the shortest onset latency and lowest AMT for both stimulations. However contralateral MEPs required lower AMT and exhibited shorter onset latency than ipsilateral MEPs (p < 0.05).

Conclusions

Ipsilateral motor pathways of the external oblique muscles have physiological features unlike those of contralateral motor pathways.

Significance

These findings suggest differential cortical control between contralateral and ipsilateral pathways in trunk muscles and provide bases for additional investigations into ipsilateral motor control.

目的颅磁刺激（TMS）被广泛应用于人体运动功能的研究。本研究旨在探讨对侧和同侧皮层控制躯干肌肉对侧和同侧外斜肌运动诱发电位（MEPs）的差异。方法对20名健康参与者进行了检查：10名年轻人和10名老年人。他们接受TMS定位对侧和同侧热点。对于年轻组中确定的热点，线圈定位在八个方向上，每个方向间隔45度，以测量主动运动阈值（AMT）和发作潜伏期。结果所有参与者均获得对侧MEPs，而20名参与者中有14名检测到同侧MEPs。同侧热点位置较Cz偏外侧（p < 0.05）。线圈定向在大脑中诱导的前正中定向电流在两种刺激中产生了最短的发作潜伏期和最低的AMT。然而，与同侧MEPs相比，对侧MEPs需要更低的AMT，并且表现出更短的发病潜伏期（p < 0.05）。结论腹外斜肌单侧运动通路具有不同于对侧运动通路的生理特征。这些发现表明躯干肌肉对侧和同侧通路的皮层控制存在差异，为进一步研究同侧运动控制提供了基础。

{"title":"Ipsilateral and contralateral cortical control of the external oblique muscles revealed by TMS","authors":"Ryoji Miyano , Yuichiro Shirota , Satoshi Kodama , Tatsushi Toda , Masashi Hamada","doi":"10.1016/j.clinph.2025.2111400","DOIUrl":"10.1016/j.clinph.2025.2111400","url":null,"abstract":"<div><h3>Objectives</h3><div>Transcranial magnetic stimulation (TMS) is used widely to explore human motor function. This study was conducted to investigate the differences between contralateral and ipsilateral cortical control on trunk muscles for eliciting contralateral and ipsilateral motor evoked potentials (MEPs) in the external oblique muscles.</div></div><div><h3>Methods</h3><div>Twenty healthy participants were examined: 10 younger and 10 older adults. They underwent TMS to locate contralateral and ipsilateral hot spots. For the identified hot spots in the younger group, the coil was positioned in eight orientations, each separated by 45 degrees, to measure active motor threshold (AMT) and onset latencies.</div></div><div><h3>Results</h3><div>Contralateral MEPs were obtained from all participants, whereas ipsilateral MEPs were detected in 14 out of 20 participants. The ipsilateral hot spots were located more laterally from Cz (<em>p</em> < 0.05). Coil orientation that induced an antero-medially directed current in the brain produced the shortest onset latency and lowest AMT for both stimulations. However contralateral MEPs required lower AMT and exhibited shorter onset latency than ipsilateral MEPs (<em>p</em> < 0.05).</div></div><div><h3>Conclusions</h3><div>Ipsilateral motor pathways of the external oblique muscles have physiological features unlike those of contralateral motor pathways.</div></div><div><h3>Significance</h3><div>These findings suggest differential cortical control between contralateral and ipsilateral pathways in trunk muscles and provide bases for additional investigations into ipsilateral motor control.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111400"},"PeriodicalIF":3.6,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of preoperative and intraoperative motor cortex excitability in brain tumor patients using regressions and machine learning 应用回归和机器学习分析脑肿瘤患者术前和术中运动皮质兴奋性的相关性。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-21 DOI: 10.1016/j.clinph.2025.2111384

Hanna Lenggenhager , Jonathan Wermelinger , Philippe Schucht, Claire Descombes, Andreas Raabe, Katharina Lutz , Kathleen Seidel

Objective

We compared the preoperative navigated transcranial magnetic stimulation (nTMS) resting motor threshold (RMT) with the intraoperative neurophysiological monitoring (IONM) motor threshold (MT) in relation to clinical and tumor characteristics.

Methods

We retrospectively analyzed the data of 65 patients with motor eloquent supratentorial tumors, preoperative nTMS and resection with IONM. An nTMS and IONM threshold ratio was defined by dividing the motor evoked potential (MEP) (R)MT of the tumor-affected side by that of the healthy side. A random forest (machine learning (ML) algorithm) was implemented to distinguish the tumor side from the healthy side based on MEPs.

Results

Tumor side nTMS-RMT and IONM-MT were significantly higher than that of the healthy side, most notably for tumors in the precentral gyrus. A positive linear correlation between nTMS-RMT_ratio and IONM-MT_ratio was observed. The random forest classifier achieved an accuracy of >90 % with the nTMS and IONM MEP data.

Conclusion

We observed lower excitability in the tumor-affected hemisphere in pre- and intraoperative data, particularly with tumors in the precentral gyrus. Low preoperative excitability during nTMS correlated with lower intraoperative excitability.

Significance

Preoperative nTMS mapping might influence the selection of intraoperative stimulation intensities to reduce the risk of false negative mapping.

目的：比较术前导航经颅磁刺激（nTMS）静息运动阈值（RMT）与术中神经生理监测（IONM）运动阈值（MT）与临床和肿瘤特征的关系。方法：回顾性分析65例幕上肿瘤患者术前nTMS及IONM切除的资料。用肿瘤一侧的运动诱发电位（MEP） (R)MT除以健康侧的运动诱发电位(R)MT来定义nTMS和IONM阈值比值。基于mep实现随机森林（机器学习（ML）算法）来区分肿瘤侧和健康侧。结果：肿瘤侧nTMS-RMT和IONM-MT均显著高于健康侧，以中心前回肿瘤最为显著。nTMS-RMTratio与IONM-MTratio呈线性正相关。随机森林分类器在nTMS和IONM MEP数据上的准确率达到了90%。结论：我们在术前和术中观察到肿瘤影响半球的低兴奋性，特别是在中央前回的肿瘤。nTMS期间术前低兴奋性与术中低兴奋性相关。意义：术前nTMS测图可能影响术中刺激强度的选择，以降低假阴性测图的风险。

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引用次数: 0

Risk factors for intraoperative seizures during asleep motor evoked potential monitoring in supratentorial surgery 幕上手术中睡眠运动诱发电位监测术中癫痫发作的危险因素

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-17 DOI: 10.1016/j.clinph.2025.2111387

Cristiano Parisi , Davide Giampiccolo , Vincenzo Tramontano , Pietro Meneghelli , Nicola Tommasi , Marco Galuppo , Federica Basaldella , Francesco Sala

Objective

Intraoperative-seizures(IOS) following direct electrical stimulation(DES) affects intraoperative neurophysiological monitoring(IONM) and may lead to stop surgical resection. We analyzed IOS risk factors during asleep brain surgery.

Methods

We reviewed 232 consecutive patients who underwent surgery for supratentorial brain lesions with IONM, that consisted in motor evoked potentials monitoring and mapping, elicited by DES using the train-of-five technique. Preoperative history of seizures, paresis, use of anti-seizure medications(ASM), stimulated cortical regions, histology, and motor performance were evaluated.

IOS was defined as clinical seizure or an after-discharge.

Results

IOS occurred in 35 patients (15.1 %). IOS risk increased with higher stimulation intensities, younger age, cavernomas, and a history of seizures, especially in patients without ASM at the time of surgery. IOS did not significantly impact the extent of resection or clinical outcome, but prolonged hospital stays.

Conclusion

Our findings suggest that lower stimulation intensities are advisable when operating on patients with specific risk factors for IOS.

Significance

We observed a significant increase in IOS risk with stimulation above 20 mA, thresholds being lower in high-risk patients. Tailored stimulation can reduce the risk of IOS. This study presents a large series on IOS risk factors during asleep surgeries and provides a review of these factors.

目的直接电刺激（DES）后术中癫痫发作（IOS）影响术中神经生理监测（IONM），可能导致手术停止切除。我们分析了睡眠脑外科手术中IOS的危险因素。方法我们回顾了232例连续接受脑幕上病变手术的患者，其中包括运动诱发电位监测和作图，由DES使用五列技术引发。评估术前癫痫发作史、轻瘫、抗癫痫药物（ASM）的使用、受刺激的皮质区域、组织学和运动表现。IOS定义为临床发作或出院后。结果35例患者发生os，占15.1%。刺激强度越高、年龄越小、有海绵状瘤、有癫痫发作史，尤其是手术时无ASM的患者，发生IOS的风险越高。IOS对切除程度或临床结果没有显著影响，但会延长住院时间。结论对于有特定危险因素的患者，宜降低刺激强度。我们观察到，当刺激超过20 mA时，IOS风险显著增加，高危患者的阈值较低。量身定制的刺激可以降低IOS的风险。本研究提出了一系列关于睡眠手术中IOS的危险因素，并对这些因素进行了综述。

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引用次数: 0

Phase cancellations of Aδ sensory fibers revealed by lidocaine 利多卡因显示的Aδ感觉纤维相消

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-17 DOI: 10.1016/j.clinph.2025.2111389

Winfried Raabe

引用次数: 0

Corticospinal imbalance following major upper limb amputation is transiently modulated by continuous theta burst stimulation 主要上肢截肢后的皮质脊髓失衡可通过持续的θ波爆发刺激进行短暂调节

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-16 DOI: 10.1016/j.clinph.2025.2111381

Emma Falato , Federico Ranieri , Gabriella Musumeci , Marco D’Alonzo , Fioravante Capone , Giovanni Di Pino , Fabio Pilato , Vincenzo Di Lazzaro

Objective

Major upper limb amputation (mULA) induces neuroplastic changes that can impact neurorehabilitation and prosthetic control. Previous literature suggested heightened corticospinal excitability (CE) in the hemisphere contralateral to the amputation (CLH). This interhemispheric imbalance in CE might represent a maladaptive process. We aimed to assess baseline CE in individuals with chronic mULA and the acute effects of continuous theta burst stimulation (cTBS) applied to the primary motor cortex (M1) contralateral to the amputation.

Methods

Thirteen adults with chronic transradial or transhumeral mULA underwent electrophysiological assessments before and after unilateral cTBS. CE was measured through motor-evoked potential (MEP) amplitudes at baseline, 5 and 10 min post-stimulation. Linear mixed models assessed the effects of Hemisphere (contralateral vs ipsilateral), Time (baseline, 5, 10 min), and their interaction.

Results

Group-level analyses indicated higher MEP amplitudes in the CLH compared with the ipsilateral hemisphere. cTBS was associated with a transient reduction of MEP amplitudes in the stimulated CLH at 5 minutes, with partial recovery at 10 minutes, leading to a temporary attenuation of interhemispheric asymmetry.

Conclusions

These findings suggest that cTBS may transiently modulate CE in chronic mULA, with effects that appear restricted to the stimulated hemisphere.

Significance

This study provides preliminary evidence of interhemispheric asymmetry in CE after mULA and indicates that cTBS could represent a potential tool to modulate it. Further studies are needed to establish robustness and clinical relevance.

目的：主要上肢截肢（mULA）引起神经可塑性改变，影响神经康复和假肢控制。先前的文献表明，在截肢（CLH）的对侧半球皮质脊髓兴奋性（CE）升高。CE的这种半球间失衡可能代表了一种适应不良的过程。我们的目的是评估慢性mULA患者的基线CE和持续θ波爆发刺激（cTBS）对截肢侧初级运动皮质（M1）的急性效果。方法对13例成人慢性经桡骨或肱骨mULA患者行单侧cTBS前后电生理评估。通过运动诱发电位（MEP）在基线、刺激后5和10分钟测量CE。线性混合模型评估了半球（对侧与同侧）、时间（基线、5分钟、10分钟）及其相互作用的影响。结果组水平分析显示，与同侧半球相比，CLH的MEP振幅更高。cTBS与受刺激CLH的MEP振幅在5分钟内短暂降低有关，在10分钟后部分恢复，导致半球间不对称性暂时减弱。这些发现表明cTBS可能会短暂地调节慢性mULA的CE，其作用似乎仅限于受刺激的半球。本研究提供了mULA后CE半球间不对称的初步证据，表明cTBS可能是一种潜在的调节工具。需要进一步的研究来建立稳健性和临床相关性。

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引用次数: 0

Attenuated theta-band activity and cross-frequency coupling in schizophrenia during affective response inhibition 情感反应抑制期间精神分裂症的θ波段活性减弱和交叉频率耦合。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-15 DOI: 10.1016/j.clinph.2025.2111386

Jacob D. Kraft , Takakuni Suzuki , Margo W. Menkes , Carolyn M. Andrews , Melvin G. McInnis , Patricia J. Deldin , Ivy F. Tso

Objective

Schizophrenia (SZ) is marked by impaired cognitive control; however, the underlying neural mechanisms remain unclear. This study examined theta-band (4–7 Hz) neural oscillatory activity and cross-frequency coupling with gamma (30–50 Hz) in an affective cognitive control paradigm in SZ in comparison with healthy controls (HC) and those with bipolar disorder (BD). Methods: Thirty-two participants with SZ, 67 with BD, and 48 HC completed an affective Go/No-Go Task with emotional face stimuli during electroencephalography recording. Time-frequency decomposition quantified theta-band power and intertrial phase consistency (ITPC) over midline fronto-central areas. Theta-gamma phase-amplitude coupling (PAC; Kullback-Leibler Modulation Index) was indexed within the midline frontal area and cross-regionally between midline frontal theta and bilateral parietal gamma. Results: Participants with SZ displayed decreased midline frontal theta power, ITPC, and local midline frontal theta-gamma PAC compared to HC, with BD falling in between SZ and HC groups across all these measures. Theta power, ITPC, and theta-gamma PAC were correlated with behavioral performance, particularly in the SZ group. Conclusion: Findings show abnormalities across the amplitude, phase consistency, and cross-frequency coordination aspects of theta-related activity when individuals with SZ engage in affective cognitive control. Significance: This study supports the assertion that SZ is associated with abnormal theta-related neural activity.

目的：精神分裂症（SZ）以认知控制功能受损为特征；然而，潜在的神经机制尚不清楚。本研究考察了情感认知控制范式下SZ与健康对照（HC）和双相情感障碍（BD）患者的theta波段（4- 7hz）神经振荡活动和与gamma （30- 50hz）的交叉频率耦合。方法：在脑电图记录中，32例SZ、67例BD和48例HC患者完成了情绪性面部刺激的情感性Go/No-Go任务。时频分解量化了中线前中央区域的波段功率和试验间相位一致性。theta -gamma相位振幅耦合（PAC； Kullback-Leibler调制指数）在额叶中线区域内以及额叶中线θ和双侧顶叶伽马之间的跨区域被索引。结果：与HC组相比，SZ组的参与者表现出较低的中线额波功率、ITPC和局部中线额波theta-gamma PAC，在所有这些测量中，BD介于SZ组和HC组之间。Theta功率、ITPC和Theta -gamma PAC与行为表现相关，尤其是在SZ组。结论：研究结果显示，当SZ患者参与情感认知控制时，theta相关活动的振幅、相位一致性和交叉频率协调方面都存在异常。意义：本研究支持SZ与异常的θ相关神经活动相关的论断。

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引用次数: 0