Pub Date : 2024-11-19DOI: 10.1016/j.clinph.2024.11.007
Valentina Hrtonova , Petr Nejedly , Vojtech Travnicek , Jan Cimbalnik , Barbora Matouskova , Martin Pail , Laure Peter-Derex , Christophe Grova , Jean Gotman , Josef Halamek , Pavel Jurak , Milan Brazdil , Petr Klimes , Birgit Frauscher
Introduction
Precise localization of the epileptogenic zone is critical for successful epilepsy surgery. However, imbalanced datasets in terms of epileptic vs. normal electrode contacts and a lack of standardized evaluation guidelines hinder the consistent evaluation of automatic machine learning localization models.
Methods
This study addresses these challenges by analyzing class imbalance in clinical datasets and evaluating common assessment metrics. Data from 139 drug-resistant epilepsy patients across two Institutions were analyzed. Metric behaviors were examined using clinical and simulated data.
Results
Complementary use of Area Under the Receiver Operating Characteristic (AUROC) and Area Under the Precision-Recall Curve (AUPRC) provides an optimal evaluation approach. This must be paired with an analysis of class imbalance and its impact due to significant variations found in clinical datasets.
Conclusions
The proposed framework offers a comprehensive and reliable method for evaluating machine learning models in epileptogenic zone localization, improving their precision and clinical relevance.
Significance
Adopting this framework will improve the comparability and multicenter testing of machine learning models in epileptogenic zone localization, enhancing their reliability and ultimately leading to better surgical outcomes for epilepsy patients.
{"title":"Metrics for evaluation of automatic epileptogenic zone localization in intracranial electrophysiology","authors":"Valentina Hrtonova , Petr Nejedly , Vojtech Travnicek , Jan Cimbalnik , Barbora Matouskova , Martin Pail , Laure Peter-Derex , Christophe Grova , Jean Gotman , Josef Halamek , Pavel Jurak , Milan Brazdil , Petr Klimes , Birgit Frauscher","doi":"10.1016/j.clinph.2024.11.007","DOIUrl":"10.1016/j.clinph.2024.11.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Precise localization of the epileptogenic zone is critical for successful epilepsy surgery. However, imbalanced datasets in terms of epileptic vs. normal electrode contacts and a lack of standardized evaluation guidelines hinder the consistent evaluation of automatic machine learning localization models.</div></div><div><h3>Methods</h3><div>This study addresses these challenges by analyzing class imbalance in clinical datasets and evaluating common assessment metrics. Data from 139 drug-resistant epilepsy patients across two Institutions were analyzed. Metric behaviors were examined using clinical and simulated data.</div></div><div><h3>Results</h3><div>Complementary use of Area Under the Receiver Operating Characteristic (AUROC) and Area Under the Precision-Recall Curve (AUPRC) provides an optimal evaluation approach. This must be paired with an analysis of class imbalance and its impact due to significant variations found in clinical datasets.</div></div><div><h3>Conclusions</h3><div>The proposed framework offers a comprehensive and reliable method for evaluating machine learning models in epileptogenic zone localization, improving their precision and clinical relevance.</div></div><div><h3>Significance</h3><div>Adopting this framework will improve the comparability and multicenter testing of machine learning models in epileptogenic zone localization, enhancing their reliability and ultimately leading to better surgical outcomes for epilepsy patients.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 33-46"},"PeriodicalIF":3.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-16DOI: 10.1016/j.clinph.2024.11.001
Anne B. Arnett , Matthew Zimon , Sambridhi Subedi , Virginia Peisch , Erica Ferrara , Gaelle Gourdet , Carissa Mastrangelo
Background
Aperiodic resting electroencephalography (EEG) activity is dynamic, reflecting shifting excitatory:inhibitory (E:I) balance with changing environmental conditions. We examined developmental and cognitive correlates of aperiodic and dynamic aperiodic indices in a cross-sequential cohort of early, middle, and late childhood youth with and without attention deficit hyperactivity disorder (ADHD).
Methods
Two-hundred eighty-five children ages 2 – 14 years provided resting EEG during high- and low-visual input conditions. Licensed clinical psychologists determined ADHD diagnosis or likelihood (in young children). Linear regressions were estimated to examine associations between aperiodic features and age, ADHD diagnosis, IQ, and experimental condition.
Results
From early to middle childhood, the aperiodic exponent increased linearly, indicating lower E:I, followed by a decreasing trajectory in late childhood. The aperiodic exponent was greater with high versus low visual input in young children, but this effect reversed with age. The ADHD group had a decreased aperiodic exponent, overall. Dynamic aperiodic activity, i.e. shifts in E:I balance, was associated with IQ.
Conclusions
The aperiodic exponent and aperiodic dynamics are proxies for age-related cortical maturation and E:I balance, and have distinct associations with ADHD symptoms and cognitive ability.
Significance
We provide novel evidence that dynamic aperiodic activity is a candidate marker of cortical efficiency in childhood.
{"title":"EEG aperiodic dynamics from early through late childhood: Associations with ADHD, cognition, and development","authors":"Anne B. Arnett , Matthew Zimon , Sambridhi Subedi , Virginia Peisch , Erica Ferrara , Gaelle Gourdet , Carissa Mastrangelo","doi":"10.1016/j.clinph.2024.11.001","DOIUrl":"10.1016/j.clinph.2024.11.001","url":null,"abstract":"<div><h3>Background</h3><div>Aperiodic resting electroencephalography (EEG) activity is dynamic, reflecting shifting excitatory:inhibitory (E:I) balance with changing environmental conditions. We examined developmental and cognitive correlates of aperiodic and dynamic aperiodic indices in a cross-sequential cohort of early, middle, and late childhood youth with and without attention deficit hyperactivity disorder (ADHD).</div></div><div><h3>Methods</h3><div>Two-hundred eighty-five children ages 2 – 14 years provided resting EEG during high- and low-visual input conditions. Licensed clinical psychologists determined ADHD diagnosis or likelihood (in young children). Linear regressions were estimated to examine associations between aperiodic features and age, ADHD diagnosis, IQ, and experimental condition.</div></div><div><h3>Results</h3><div>From early to middle childhood, the aperiodic exponent increased linearly, indicating lower E:I, followed by a decreasing trajectory in late childhood. The aperiodic exponent was greater with high versus low visual input in young children, but this effect reversed with age. The ADHD group had a decreased aperiodic exponent, overall. Dynamic aperiodic activity, i.e. shifts in E:I balance, was associated with IQ.</div></div><div><h3>Conclusions</h3><div>The aperiodic exponent and aperiodic dynamics are proxies for age-related cortical maturation and E:I balance, and have distinct associations with ADHD symptoms and cognitive ability.</div></div><div><h3>Significance</h3><div>We provide novel evidence that dynamic aperiodic activity is a candidate marker of cortical efficiency in childhood.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 161-167"},"PeriodicalIF":3.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-16DOI: 10.1016/j.clinph.2024.11.003
Markus Kofler , Josep Valls-Solé , Michael Thurner , Elke Pucks-Faes , Viviana Versace
Objective
Blink reflexes following supraorbital nerve (SON) stimulation are typically modulated by conditioning stimuli (CS) to the index finger (D2) (low-intensity, prepulse inhibition paradigm) or SON (same intensity, paired-pulse paradigm). We aimed to disentangle whether CS-intensity or CS-induced motor responses define blink reflex modulation.
Methods
In 35 subjects, test SON stimuli (8 times sensory threshold, 8 × ST) were applied either alone or following CS. In experiment 1, CS were delivered to D2 with low (2 × ST) or high intensity (inducing a somatosensory blink reflex). In experiment 2, CS were applied to SON with low (<2 × ST) or test intensity. Test blink reflex size was correlated to CS-intensity and to CS-induced motor response size. Relative strength of their influence was determined in regression analyses.
Results
Test blink reflex size showed higher inverse correlation to CS-intensity than to CS-induced motor response size for both CS delivered to D2 or SON. Regression analyses confirmed a significantly higher relative strength of CS-intensity than of CS-induced motor response size.
Conclusions
The sensory input of CS, rather than CS-induced motor output, defines subsequent blink reflex modulation.
Significance
This ubiquitous phenomenon calls for caution when relating the size of test responses to the size of conditioning responses particularly in paired-pulse paradigms.
{"title":"The sensory input, not the motor output, defines blink reflex conditioning","authors":"Markus Kofler , Josep Valls-Solé , Michael Thurner , Elke Pucks-Faes , Viviana Versace","doi":"10.1016/j.clinph.2024.11.003","DOIUrl":"10.1016/j.clinph.2024.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>Blink reflexes following supraorbital nerve (SON) stimulation are typically modulated by conditioning stimuli (CS) to the index finger (D2) (low-intensity, prepulse inhibition paradigm) or SON (same intensity, paired-pulse paradigm). We aimed to disentangle whether CS-intensity or CS-induced motor responses define blink reflex modulation.</div></div><div><h3>Methods</h3><div>In 35 subjects, test SON stimuli (8 times sensory threshold, 8 × ST) were applied either alone or following CS. In <em>experiment 1</em>, CS were delivered to D2 with low (2 × ST) or high intensity (inducing a somatosensory blink reflex). In <em>experiment 2</em>, CS were applied to SON with low (<2 × ST) or test intensity. Test blink reflex size was correlated to CS-intensity and to CS-induced motor response size. Relative strength of their influence was determined in regression analyses.</div></div><div><h3>Results</h3><div>Test blink reflex size showed higher inverse correlation to CS-intensity than to CS-induced motor response size for both CS delivered to D2 or SON. Regression analyses confirmed a significantly higher relative strength of CS-intensity than of CS-induced motor response size.</div></div><div><h3>Conclusions</h3><div>The sensory input of CS, rather than CS-induced motor output, defines subsequent blink reflex modulation.</div></div><div><h3>Significance</h3><div>This ubiquitous phenomenon calls for caution when relating the size of test responses to the size of conditioning responses particularly in paired-pulse paradigms.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 168-175"},"PeriodicalIF":3.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-16DOI: 10.1016/j.clinph.2024.11.004
Victor H. Souza , Jaakko O. Nieminen , Sergei Tugin , Lari M. Koponen , Ulf Ziemann , Oswaldo Baffa , Risto J. Ilmoniemi
Objective
Electric-field orientation is crucial for optimizing neuronal excitation in transcranial magnetic stimulation (TMS). Yet, the stimulus orientation effects on short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) are poorly understood due to technical challenges in manipulating the TMS-induced stimulus orientation within milliseconds. We aimed to assess the orientation sensitivity of SICI and ICF paradigms and identify optimal orientations for motor evoked potential (MEP) facilitation and suppression.
Methods
We applied paired-pulse multi-channel TMS to 12 healthy subjects with conditioning and test stimuli in the same, opposite, and perpendicular orientations to each other at four interstimulus intervals (ISI) to generate refractoriness, SICI, and ICF.
Results
MEP modulation was affected by the conditioning- and test-stimulus orientation, being strongest when both pulses were in the same direction. MEP modulation with 2.5-ms and 6.0-ms ISIs were more sensitive to orientation changes than 0.5- and 8.0-ms ISIs.
Conclusion
SICI and ICF orientation sensitivity exhibit a complex dependence on the conditioning stimulus orientation, which might be explained by anatomical and morphological arrangements of inhibitory and excitatory neuronal populations.
Significance
Distinct mechanisms mediating SICI and ICF are sensitive to stimulus orientation at specific ISIs, describing a structural–functional relationship that maximizes each effect at the cortical level.
{"title":"Probing the orientation specificity of excitatory and inhibitory circuitries in the primary motor cortex with multi-channel TMS","authors":"Victor H. Souza , Jaakko O. Nieminen , Sergei Tugin , Lari M. Koponen , Ulf Ziemann , Oswaldo Baffa , Risto J. Ilmoniemi","doi":"10.1016/j.clinph.2024.11.004","DOIUrl":"10.1016/j.clinph.2024.11.004","url":null,"abstract":"<div><h3>Objective</h3><div>Electric-field orientation is crucial for optimizing neuronal excitation in transcranial magnetic stimulation (TMS). Yet, the stimulus orientation effects on short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) are poorly understood due to technical challenges in manipulating the TMS-induced stimulus orientation within milliseconds. We aimed to assess the orientation sensitivity of SICI and ICF paradigms and identify optimal orientations for motor evoked potential (MEP) facilitation and suppression.</div></div><div><h3>Methods</h3><div>We applied paired-pulse multi-channel TMS to 12 healthy subjects with conditioning and test stimuli in the same, opposite, and perpendicular orientations to each other at four interstimulus intervals (ISI) to generate refractoriness, SICI, and ICF.</div></div><div><h3>Results</h3><div>MEP modulation was affected by the conditioning- and test-stimulus orientation, being strongest when both pulses were in the same direction. MEP modulation with 2.5-ms and 6.0-ms ISIs were more sensitive to orientation changes than 0.5- and 8.0-ms ISIs.</div></div><div><h3>Conclusion</h3><div>SICI and ICF orientation sensitivity exhibit a complex dependence on the conditioning stimulus orientation, which might be explained by anatomical and morphological arrangements of inhibitory and excitatory neuronal populations.</div></div><div><h3>Significance</h3><div>Distinct mechanisms mediating SICI and ICF are sensitive to stimulus orientation at specific ISIs, describing a structural–functional relationship that maximizes each effect at the cortical level.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 23-32"},"PeriodicalIF":3.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noisy galvanic vestibular stimulation (GVS) using weak random noise waveforms enhances postural stability by modulating vestibular-related neural networks. This study aimed to investigate the neural interference mechanisms of noisy GVS on lateral vestibulospinal tract (LVST) excitability.
Methods
Twenty-six healthy volunteers were randomly divided into two groups: balance training combined with noisy GVS and sham GVS. Participants performed 10-minute balance training while standing on a soft foam surface with their eyes closed while adapting to each electrical stimulus. LVST excitability was assessed by measuring the soleus H-reflex following square-wave pulse GVS. Postural stability was measured by assessing the center of foot pressure sway while standing on a foam surface with eyes closed.
Results
The noisy GVS group showed significantly increased post-intervention H-reflex amplitude. The sham GVS group showed no significant difference in H-reflex amplitude pre- and post-intervention. The average sway velocity in the noisy and sham GVS groups significantly decreased in the medial–lateral direction of the center of foot pressure.
Conclusions
Noisy GVS may enhance LVST excitability and decrease body sway via vestibular system interference during holding upright, which relies heavily on vestibular sensations.
Significance
These findings may help understand the neural mechanisms of noisy GVS in neurorehabilitation.
{"title":"Neural interference effects on lateral vestibulospinal tract excitability by noisy galvanic vestibular stimulation","authors":"Tsubasa Mitsutake , Hisato Nakazono , Tomoyuki Shiozaki , Takanori Taniguchi , Hisayoshi Yoshizuka , Maiko Sakamoto","doi":"10.1016/j.clinph.2024.11.002","DOIUrl":"10.1016/j.clinph.2024.11.002","url":null,"abstract":"<div><h3>Objective</h3><div>Noisy galvanic vestibular stimulation (GVS) using weak random noise waveforms enhances postural stability by modulating vestibular-related neural networks. This study aimed to investigate the neural interference mechanisms of noisy GVS on lateral vestibulospinal tract (LVST) excitability.</div></div><div><h3>Methods</h3><div>Twenty-six healthy volunteers were randomly divided into two groups: balance training combined with noisy GVS and sham GVS. Participants performed 10-minute balance training while standing on a soft foam surface with their eyes closed while adapting to each electrical stimulus. LVST excitability was assessed by measuring the soleus H-reflex following square-wave pulse GVS. Postural stability was measured by assessing the center of foot pressure sway while standing on a foam surface with eyes closed.</div></div><div><h3>Results</h3><div>The noisy GVS group showed significantly increased post-intervention H-reflex amplitude. The sham GVS group showed no significant difference in H-reflex amplitude pre- and post-intervention. The average sway velocity in the noisy and sham GVS groups significantly decreased in the medial–lateral direction of the center of foot pressure.</div></div><div><h3>Conclusions</h3><div>Noisy GVS may enhance LVST excitability and decrease body sway via vestibular system interference during holding upright, which relies heavily on vestibular sensations.</div></div><div><h3>Significance</h3><div>These findings may help understand the neural mechanisms of noisy GVS in neurorehabilitation.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 153-160"},"PeriodicalIF":3.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-06DOI: 10.1016/j.clinph.2024.10.014
Agnese Zazio , Cora Miranda Lanza , Antonietta Stango , Giacomo Guidali , Eleonora Marcantoni , Delia Lucarelli , Serena Meloni , Nadia Bolognini , Roberta Rossi , Marta Bortoletto
Objectives
Patients with borderline personality disorder (pw-BPD) have decreased levels of cognitive empathy, which may be subtended by mirror-like mechanisms in the somatosensory cortices, i.e., the Tactile Mirror System (TaMS). Here, we aimed to shed light on the TaMS and empathic deficits in pw-BPD focusing on connectivity, using transcranial magnetic stimulation and electroencephalography (TMS-EEG).
Methods
After study preregistration, we collected self-report measures of empathic abilities, behavioral performance in a visuo-tactile spatial congruency task investigating TaMS activity, and TMS-evoked potentials (TEPs) from 20 pw-BPD and 20 healthy controls. TMS was delivered over the right primary somatosensory cortex (S1) during touch observation and real touch delivery.
Results
Pw-BPD reported significantly lower levels of cognitive empathy than controls and made significantly more errors in reporting the side of real touches during touch observation. Moreover, pw-BPD presented an altered connectivity pattern from S1-TEPs during touch perception and touch observation, in the last case without differences between human- and object-directed touches.
Conclusions
The results do not support a specific impairment of TaMS in pw-BPD, but reveal significant behavioral and connectivity alterations within the somatosensory network during touch processing.
Significance
The present findings temper the proposed role of the TaMS in BPD, while still highlighting the involvement of somatosensory network alterations.
{"title":"Investigating visuo-tactile mirror properties in borderline personality disorder: A TMS-EEG study","authors":"Agnese Zazio , Cora Miranda Lanza , Antonietta Stango , Giacomo Guidali , Eleonora Marcantoni , Delia Lucarelli , Serena Meloni , Nadia Bolognini , Roberta Rossi , Marta Bortoletto","doi":"10.1016/j.clinph.2024.10.014","DOIUrl":"10.1016/j.clinph.2024.10.014","url":null,"abstract":"<div><h3>Objectives</h3><div>Patients with borderline personality disorder (pw-BPD) have decreased levels of cognitive empathy, which may be subtended by mirror-like mechanisms in the somatosensory cortices, i.e., the Tactile Mirror System (TaMS). Here, we aimed to shed light on the TaMS and empathic deficits in pw-BPD focusing on connectivity, using transcranial magnetic stimulation and electroencephalography (TMS-EEG).</div></div><div><h3>Methods</h3><div>After study preregistration, we collected self-report measures of empathic abilities, behavioral performance in a visuo-tactile spatial congruency task investigating TaMS activity, and TMS-evoked potentials (TEPs) from 20 pw-BPD and 20 healthy controls. TMS was delivered over the right primary somatosensory cortex (S1) during touch observation and real touch delivery.</div></div><div><h3>Results</h3><div>Pw-BPD reported significantly lower levels of cognitive empathy than controls and made significantly more errors in reporting the side of real touches during touch observation. Moreover, pw-BPD presented an altered connectivity pattern from S1-TEPs during touch perception and touch observation, in the last case without differences between human- and object-directed touches.</div></div><div><h3>Conclusions</h3><div>The results do not support a specific impairment of TaMS in pw-BPD, but reveal significant behavioral and connectivity alterations within the somatosensory network during touch processing.</div></div><div><h3>Significance</h3><div>The present findings temper the proposed role of the TaMS in BPD, while still highlighting the involvement of somatosensory network alterations.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 139-152"},"PeriodicalIF":3.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.clinph.2024.09.020
Noah S. Philip, Amanda R. Arulpragasam
{"title":"Listening for the beat: Low intensity ultrasound modulates heartbeat evoked potentials","authors":"Noah S. Philip, Amanda R. Arulpragasam","doi":"10.1016/j.clinph.2024.09.020","DOIUrl":"10.1016/j.clinph.2024.09.020","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"167 ","pages":"Pages 264-266"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.clinph.2024.09.006
Andrew Strohman , Gabriel Isaac , Brighton Payne , Charles Verdonk , Sahib S. Khalsa , Wynn Legon
Objective
The heartbeat evoked potential (HEP) is a brain response time-locked to the heartbeat and a potential marker of interoceptive processing that may be generated in the insula and dorsal anterior cingulate cortex (dACC). Low-intensity focused ultrasound (LIFU) can selectively modulate sub-regions of the insula and dACC to better understand their contributions to the HEP.
Methods
Healthy participants (n = 16) received stereotaxically targeted LIFU to the anterior insula (AI), posterior insula (PI), dACC, or Sham at rest during continuous electroencephalography (EEG) and electrocardiography (ECG) recording on separate days. Primary outcome was HEP amplitudes. Relationships between LIFU pressure and HEP changes and effects of LIFU on heart rate and heart rate variability (HRV) were also explored.
Results
Relative to sham, LIFU to the PI, but not AI or dACC, decreased HEP amplitudes; PI effects were partially explained by increased LIFU pressure. LIFU did not affect heart rate or HRV.
Conclusions
These results demonstrate the ability to modulate HEP amplitudes via non-invasive targeting of key interoceptive brain regions.
Significance
Our findings have implications for the causal role of these areas in bottom-up heart-brain communication that could guide future work investigating the HEP as a marker of interoceptive processing in healthy and clinical populations.
目的：心跳诱发电位（HEP心跳诱发电位（HEP）是一种与心跳时间锁定的大脑反应，也是可能在脑岛和背侧前扣带回皮层（dACC）中产生的感知间处理的潜在标记。低强度聚焦超声（LIFU）可选择性地调节岛叶和dACC的子区域，从而更好地了解它们对HEP的贡献。方法：健康参与者（n = 16）在连续脑电图（EEG）和心电图（ECG）记录期间，分别在前岛叶（AI）、后岛叶（PI）、dACC或静息时接受立体定向LIFU。主要结果是HEP振幅。此外，还探讨了 LIFU 压力与 HEP 变化之间的关系，以及 LIFU 对心率和心率变异性（HRV）的影响：结果：与假性相比，LIFU 对 PI（而非 AI 或 dACC）的影响降低了 HEP 波幅；LIFU 压力的增加部分解释了对 PI 的影响。LIFU 不影响心率或心率变异：这些结果表明，通过对关键的感知间脑区进行非侵入性靶向治疗，能够调节 HEP 波幅：我们的研究结果对这些区域在自下而上的心脑交流中的因果作用具有重要意义，可指导未来研究 HEP 作为健康和临床人群感知间处理标记的工作。
{"title":"Low-intensity focused ultrasound to the insula differentially modulates the heartbeat-evoked potential: A proof-of-concept study","authors":"Andrew Strohman , Gabriel Isaac , Brighton Payne , Charles Verdonk , Sahib S. Khalsa , Wynn Legon","doi":"10.1016/j.clinph.2024.09.006","DOIUrl":"10.1016/j.clinph.2024.09.006","url":null,"abstract":"<div><h3>Objective</h3><div>The heartbeat evoked potential (HEP) is a brain response time-locked to the heartbeat and a potential marker of interoceptive processing that may be generated in the insula and dorsal anterior cingulate cortex (dACC). Low-intensity focused ultrasound (LIFU) can selectively modulate sub-regions of the insula and dACC to better understand their contributions to the HEP.</div></div><div><h3>Methods</h3><div>Healthy participants (<em>n</em> = 16) received stereotaxically targeted LIFU to the anterior insula (AI), posterior insula (PI), dACC, or Sham at rest during continuous electroencephalography (EEG) and electrocardiography (ECG) recording on separate days. Primary outcome was HEP amplitudes. Relationships between LIFU pressure and HEP changes and effects of LIFU on heart rate and heart rate variability (HRV) were also explored.</div></div><div><h3>Results</h3><div>Relative to sham, LIFU to the PI, but not AI or dACC, decreased HEP amplitudes; PI effects were partially explained by increased LIFU pressure. LIFU did not affect heart rate or HRV.</div></div><div><h3>Conclusions</h3><div>These results demonstrate the ability to modulate HEP amplitudes via non-invasive targeting of key interoceptive brain regions.</div></div><div><h3>Significance</h3><div>Our findings have implications for the causal role of these areas in bottom-up heart-brain communication that could guide future work investigating the HEP as a marker of interoceptive processing in healthy and clinical populations.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"167 ","pages":"Pages 267-281"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.clinph.2024.10.015
Yingchun Xu , Ping Jiang , Zixian Zhou , Fangzhou Liu , Yingying Tang , Ling Liu
{"title":"Polygenic mutations and their brain spatial expression contribute to presurgical evaluation in patients with refractory focal epilepsy: A case report","authors":"Yingchun Xu , Ping Jiang , Zixian Zhou , Fangzhou Liu , Yingying Tang , Ling Liu","doi":"10.1016/j.clinph.2024.10.015","DOIUrl":"10.1016/j.clinph.2024.10.015","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 129-130"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142587456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.clinph.2024.07.008
Mikael Gian Andrea Izzo , Davide Rossi Sebastiano , Valentina Catanzaro , Ylenia Melillo , Ramona Togni , Elisa Visani , Jacopo Falco , Cecilia Casali , Marco Gemma , Paolo Ferroli , Annamaria Gallone , Daniele Cazzato , Grazia Devigili , Sara Alverà , Paola Lanteri
Objective
We assessed the Transcranial Electrical Stimulation (TES)-induced Corticobulbar-Motor Evoked Potentials (Cb-MEPs) evoked from Orbicularis Oculi (Oc) and Orbicularis Oris (Or) muscles with FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6/-Cz stimulation, during IntraOperative NeuroMonitoring (IONM) in 30 patients who underwent skull-base surgery.
Methods
before (T0) and after (T1) the surgery, we compared the peak-to-peak amplitudes of Cb-MEPs obtained from TES with C3/C4-Cz, C5/C6-Cz and FCC5h/FCC6h-Mz. Then, we compared the response category (present, absent and peripheral) related to different montages. Finally, we classified the Cb-MEPs data from each patient for concordance with clinical outcome and we assessed the diagnostic measures for Cb-MEPs data obtained from FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6-Cz TES stimulation.
Results
Both at T0 and T1, FCC5h/FCC6h-Mz stimulation evoked larger Cb-MEPs than C3/C4-Cz, less peripheral responses from direct activation of facial nerve than C5/C6-Cz. FCC5h/FCC6h-Mz stimulation showed the best accuracy and specificity of Cb-MEPs for clinical outcomes.
Conclusions
FCC5h/FCC6h-Mz stimulation showed the best performances for monitoring the facial nerve functioning, maintaining excellent diagnostic measures even at low stimulus voltages.
Significance
We demonstrated that FCC5h/FCC6h-Mz TES montage for Cb-MEPs in IONM has good accuracy in predicting the post-surgery outcome of facial nerve functioning.
{"title":"Three montages for Transcranial electric stimulation in predicting the early post-surgery outcome of the facial nerve functioning","authors":"Mikael Gian Andrea Izzo , Davide Rossi Sebastiano , Valentina Catanzaro , Ylenia Melillo , Ramona Togni , Elisa Visani , Jacopo Falco , Cecilia Casali , Marco Gemma , Paolo Ferroli , Annamaria Gallone , Daniele Cazzato , Grazia Devigili , Sara Alverà , Paola Lanteri","doi":"10.1016/j.clinph.2024.07.008","DOIUrl":"10.1016/j.clinph.2024.07.008","url":null,"abstract":"<div><h3>Objective</h3><div>We assessed the Transcranial Electrical Stimulation (TES)-induced Corticobulbar-Motor Evoked Potentials (Cb-MEPs) evoked from Orbicularis Oculi (Oc) and Orbicularis Oris (Or) muscles with FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6/-Cz stimulation, during IntraOperative NeuroMonitoring (IONM) in 30 patients who underwent skull-base surgery.</div></div><div><h3>Methods</h3><div>before (T0) and after (T1) the surgery, we compared the peak-to-peak amplitudes of Cb-MEPs obtained from TES with C3/C4-Cz, C5/C6-Cz and FCC5h/FCC6h-Mz. Then, we compared the response category (present, absent and peripheral) related to different montages. Finally, we classified the Cb-MEPs data from each patient for concordance with clinical outcome and we assessed the diagnostic measures for Cb-MEPs data obtained from FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6-Cz TES stimulation.</div></div><div><h3>Results</h3><div>Both at T0 and T1, FCC5h/FCC6h-Mz stimulation evoked larger Cb-MEPs than C3/C4-Cz, less peripheral responses from direct activation of facial nerve than C5/C6-Cz. FCC5h/FCC6h-Mz stimulation showed the best accuracy and specificity of Cb-MEPs for clinical outcomes.</div></div><div><h3>Conclusions</h3><div>FCC5h/FCC6h-Mz stimulation showed the best performances for monitoring the facial nerve functioning, maintaining excellent diagnostic measures even at low stimulus voltages.</div></div><div><h3>Significance</h3><div>We demonstrated that FCC5h/FCC6h-Mz TES montage for Cb-MEPs in IONM has good accuracy in predicting the post-surgery outcome of facial nerve functioning.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"167 ","pages":"Pages 282-293"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号