Clinical Neurophysiology最新文献_第5页

Cerebellar repetitive transcranial magnetic stimulation attenuates essential tremor by modulating visuomotor network connectivity 小脑重复性经颅磁刺激通过调节视运动网络连接来减弱特发性震颤

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-07 DOI: 10.1016/j.clinph.2025.2111472

Xue Shi , Runyang He , Lin Zhu , Nan Yan , Shaoxia Fan , Zian Pei , Xiaolin Su , Fali Li , Yumei Liu , Ge Dang , Shuhan Fan , Peng Xu , Dezhong Yao , Robert Chen , Yi Guo

Objective

To investigate the neurophysiological mechanisms underlying cerebellar repetitive transcranial magnetic stimulation (rTMS) in essential tremor (ET) using source-level electroencephalography (EEG) phase-locking value analysis.

Methods

EEG recordings and clinical assessments of ET patients (n = 20) before and after 4-week bilateral cerebellar rTMS were studied and evaluated for correlations. Brain source activities were reconstructed using standardized low-resolution brain electromagnetic tomography (LORETA). Functional connectivity and local network metrics in the alpha band (8–13 Hz) were compared with those of healthy controls (n = 20).

Results

ET patients had lower nodal efficiency in visual areas and reduced inter-regional occipital connectivity than controls. Local network metrics in the left superior occipital gyrus, left cuneus, and right fusiform gyrus negatively correlated with tremor severity and significantly improved with rTMS. Connectivity changes between the left inferior occipital gyrus (IOG) and superior parietal gyrus (SPG) and the right SPG and midcingulate cortex (MCC), strongly correlated with improvements in activities of daily living. Performance-related connectivity changes involved the left IOG-SPG, right SPG-MCC, and left middle occipital gyrus to the supplementary motor area.

Conclusions

Cerebellar rTMS may alleviate ET by reorganizing functional connectivity within the visuomotor network.

Significance

Our findings provide preliminary mechanistic insights and potential biomarkers for ET treatment, pending validation in future sham-controlled studies.

目的通过源级脑电图（EEG）锁相值分析，探讨小脑重复经颅磁刺激（rTMS）治疗特发性震颤（ET）的神经生理机制。方法对20例ET患者（n = 20）双侧小脑rTMS前后4周的seeg记录和临床评价进行研究，并评价相关性。采用标准化低分辨率脑电磁断层扫描（LORETA）重建脑源活动。将α波段（8-13 Hz）的功能连通性和局部网络指标与健康对照（n = 20）进行比较。结果与对照组相比，set组患者视觉区节效率较低，枕叶区域间连通性较差。左侧枕上回、左侧楔叶和右侧梭状回的局部网络指标与震颤严重程度呈负相关，rTMS显著改善了震颤严重程度。左侧枕下回（IOG）和顶叶上回（SPG）以及右侧SPG和中扣带皮层（MCC）之间的连通性变化与日常生活活动的改善密切相关。与表现相关的连通性变化包括左眼动脑区、右眼动脑区和左枕中回至辅助运动区。结论小脑rTMS可能通过重组视觉运动网络内的功能连接来缓解ET。我们的发现为ET治疗提供了初步的机制见解和潜在的生物标志物，有待于未来的假对照研究的验证。

{"title":"Cerebellar repetitive transcranial magnetic stimulation attenuates essential tremor by modulating visuomotor network connectivity","authors":"Xue Shi , Runyang He , Lin Zhu , Nan Yan , Shaoxia Fan , Zian Pei , Xiaolin Su , Fali Li , Yumei Liu , Ge Dang , Shuhan Fan , Peng Xu , Dezhong Yao , Robert Chen , Yi Guo","doi":"10.1016/j.clinph.2025.2111472","DOIUrl":"10.1016/j.clinph.2025.2111472","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the neurophysiological mechanisms underlying cerebellar repetitive transcranial magnetic stimulation (rTMS) in essential tremor (ET) using source-level electroencephalography (EEG) phase-locking value analysis.</div></div><div><h3>Methods</h3><div>EEG recordings and clinical assessments of ET patients (n = 20) before and after 4-week bilateral cerebellar rTMS were studied and evaluated for correlations. Brain source activities were reconstructed using standardized low-resolution brain electromagnetic tomography (LORETA). Functional connectivity and local network metrics in the alpha band (8–13 Hz) were compared with those of healthy controls (n = 20).</div></div><div><h3>Results</h3><div>ET patients had lower nodal efficiency in visual areas and reduced inter-regional occipital connectivity than controls. Local network metrics in the left superior occipital gyrus, left cuneus, and right fusiform gyrus negatively correlated with tremor severity and significantly improved with rTMS. Connectivity changes between the left inferior occipital gyrus (IOG) and superior parietal gyrus (SPG) and the right SPG and midcingulate cortex (MCC), strongly correlated with improvements in activities of daily living. Performance-related connectivity changes involved the left IOG-SPG, right SPG-MCC, and left middle occipital gyrus to the supplementary motor area.</div></div><div><h3>Conclusions</h3><div>Cerebellar rTMS may alleviate ET by reorganizing functional connectivity within the visuomotor network.</div></div><div><h3>Significance</h3><div>Our findings provide preliminary mechanistic insights and potential biomarkers for ET treatment, pending validation in future sham-controlled studies.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111472"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detecting emotion in individuals with disorders of consciousness: a pilot study of heart rate deceleration on affective auditory stimuli 意识障碍患者的情绪检测：情感性听觉刺激下心率减速的初步研究

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1016/j.clinph.2025.2111469

Hugo Ardaillon , Anne Dubois , Kate-Mary Ndocko , Jérôme Etienne , Catherine Tallon-Baudry , Jacques Luauté

Objective

To evaluate heart rate deceleration on affective auditory stimulations as an objective marker of purposeful affective behaviour, as used in the diagnosis of minimally conscious state (MCS) in brain-injured individuals with disorders of consciousness (DoC), awake but unable to communicate.

Methods

We recorded the heart rate of participants (14 healthy controls and 10 brain injured individuals, conscious or with DoC) on repeated exposure to a random sequence of three emotional sounds of neutral, positive, and negative valence, in an unconditioned manner (experiment 1) or in a trace-conditioning procedure (experiment 2), with successful trace-conditioning assumed to indicate consciousness.

Results

In experiment 1, heart rate deceleration after aversive acoustic stimulus was significantly higher in healthy subjects at the group level from the second to the seventh inter-beat interval, with limited sensitivity at the individual level. In experiment 2, there was no evidence of trace-conditioned learning in healthy subjects, precluding any extrapolation to brain-injured individuals.

Conclusions

Heart rate deceleration after aversive acoustic stimulus was significant in passive hearing but not in a trace-conditioning paradigm and was of limited sensitivity at the individual level.

Significance

Heart rate deceleration may constitute an objective marker of purposeful affective behaviour triggered by emotional sounds. The question of whether this response is a reflex or a marker of conscious access needs further study.

目的评价情感性听觉刺激引起的心率减速作为有目的情感性行为的客观指标，在意识障碍（DoC）脑损伤患者的最低意识状态（MCS）诊断中的应用。方法：我们记录了参与者（14名健康对照者和10名有意识或有DoC的脑损伤者）在重复以无条件方式（实验1）或痕迹条件反射程序（实验2）随机序列暴露于中性、积极和消极三种情绪声音时的心率，假设成功的痕迹条件反射表明意识。结果在实验1中，健康受试者在第2 ~ 7次心跳间隔时，厌恶声刺激后的心率减速度在组水平上显著提高，但在个体水平上敏感性有限。在实验2中，没有证据表明在健康受试者中存在追踪条件学习，排除了对脑损伤个体的任何推断。结论厌声刺激后的心率减慢在被动听力中显著，但在痕迹条件反射模式中不明显，在个体水平上敏感性有限。意义心率减速可能是由情绪声音触发的有目的的情感行为的客观标志。这种反应是一种反射还是一种有意识接触的标志，这个问题需要进一步研究。

{"title":"Detecting emotion in individuals with disorders of consciousness: a pilot study of heart rate deceleration on affective auditory stimuli","authors":"Hugo Ardaillon , Anne Dubois , Kate-Mary Ndocko , Jérôme Etienne , Catherine Tallon-Baudry , Jacques Luauté","doi":"10.1016/j.clinph.2025.2111469","DOIUrl":"10.1016/j.clinph.2025.2111469","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate heart rate deceleration on affective auditory stimulations as an objective marker of purposeful affective behaviour, as used in the diagnosis of minimally conscious state (MCS) in brain-injured individuals with disorders of consciousness (DoC), awake but unable to communicate.</div></div><div><h3>Methods</h3><div>We recorded the heart rate of participants (14 healthy controls and 10 brain injured individuals, conscious or with DoC) on repeated exposure to a random sequence of three emotional sounds of neutral, positive, and negative valence, in an unconditioned manner (experiment 1) or in a trace-conditioning procedure (experiment 2), with successful trace-conditioning assumed to indicate consciousness.</div></div><div><h3>Results</h3><div>In experiment 1, heart rate deceleration after aversive acoustic stimulus was significantly higher in healthy subjects at the group level from the second to the seventh inter-beat interval, with limited sensitivity at the individual level. In experiment 2, there was no evidence of trace-conditioned learning in healthy subjects, precluding any extrapolation to brain-injured individuals.</div></div><div><h3>Conclusions</h3><div>Heart rate deceleration after aversive acoustic stimulus was significant in passive hearing but not in a trace-conditioning paradigm and was of limited sensitivity at the individual level.</div></div><div><h3>Significance</h3><div>Heart rate deceleration may constitute an objective marker of purposeful affective behaviour triggered by emotional sounds. The question of whether this response is a reflex or a marker of conscious access needs further study.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111469"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145735499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural signatures of central auditory aging under sensory and cognitive loads 感觉和认知负荷下中枢听觉老化的神经特征

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1016/j.clinph.2025.2111465

Yifat Yaar-Soffer , Brilliant Brilliant , Chava Muchnik , Andrej Kral , Yael Henkin

Objective

To investigate the neural mechanisms underlying auditory processing in older adults (OAs) under conditions of sensory-perceptual (S-P) and auditory-cognitive (A-C) loads.

Methods

Electroencephalography was recorded in 20 OAs (mean age = 69.6 ± 5.2 years) with age-appropriate hearing and preserved cognition, and 20 younger adults (YAs) (mean age = 24.9 ± 1.8 years). Participants performed tasks under S-P load (quiet vs. noise), A-C load (simple vs. demanding task), and combined load. Analyses included event-related potentials and time-frequency representations.

Results

OAs showed delayed early (N1) and late (P3) cortical responses and slower reaction times (RTs) compared to YAs. Increased alpha-band desynchronization emerged as an age-related biomarker, reflecting OAs’ reduced ability to inhibit irrelevant information. Distinct load-specific processing strategies appeared: S-P load was associated with delayed neural responses across cortical stages, longer RTs, and delta- and theta-band activity. A-C load was associated with prolonged late (P3) cortical activity, slower RTs, and broader neural recruitment across all frequency bands. Under combined load, OAs showed P3 latency prolongation, revealing vulnerability to the dual challenge of noise suppression and cognitive demand.

Conclusion

Integrated time- and frequency-domain electroencephalography analyses exposed distinct listening strategies in OAs, characterized by load-specific neural signatures.

Significance

Improved understanding of auditory processing strategies in OAs will advance targeted auditory rehabilitation.

目的探讨老年人在感觉-知觉（S-P）和听觉-认知（A-C）负荷下听觉加工的神经机制。方法对20例听力正常、认知功能完好的老年患者（平均年龄69.6±5.2岁）和20例青壮年（平均年龄24.9±1.8岁）进行脑电图记录。参与者在S-P负载（安静vs.噪音）、A-C负载（简单vs.苛刻任务）和组合负载下执行任务。分析包括事件相关电位和时频表示。结果与YAs相比，soas的早期（N1）和晚期（P3）皮质反应延迟，反应时间（RTs）减慢。α波段不同步增加是一种与年龄相关的生物标志物，反映了oa抑制无关信息的能力降低。出现了不同的负荷特异性加工策略：S-P负荷与皮层阶段延迟的神经反应、较长的RTs以及δ和θ波段活动有关。A-C负荷与延长的晚期（P3）皮质活动、较慢的RTs和更广泛的所有频带神经募集相关。在复合负荷下，OAs表现出P3潜伏期延长，表明易受到噪声抑制和认知需求的双重挑战。综合时间和频域脑电图分析揭示了oa患者不同的听力策略，其特征是负载特异性神经特征。意义提高对听力加工策略的认识，有助于促进针对性的听力康复。

{"title":"Neural signatures of central auditory aging under sensory and cognitive loads","authors":"Yifat Yaar-Soffer , Brilliant Brilliant , Chava Muchnik , Andrej Kral , Yael Henkin","doi":"10.1016/j.clinph.2025.2111465","DOIUrl":"10.1016/j.clinph.2025.2111465","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the neural mechanisms underlying auditory processing in older adults (OAs) under conditions of sensory-perceptual (S-P) and auditory-cognitive (A-C) loads.</div></div><div><h3>Methods</h3><div>Electroencephalography was recorded in 20 OAs (mean age = 69.6 ± 5.2 years) with age-appropriate hearing and preserved cognition, and 20 younger adults (YAs) (mean age = 24.9 ± 1.8 years). Participants performed tasks under S-P load (quiet vs. noise), A-C load (simple vs. demanding task), and combined load. Analyses included event-related potentials and time-frequency representations.</div></div><div><h3>Results</h3><div>OAs showed delayed early (N1) and late (P3) cortical responses and slower reaction times (RTs) compared to YAs. Increased alpha-band desynchronization emerged as an age-related biomarker, reflecting OAs’ reduced ability to inhibit irrelevant information. Distinct load-specific processing strategies appeared: S-P load was associated with delayed neural responses across cortical stages, longer RTs, and delta- and theta-band activity. A-C load was associated with prolonged late (P3) cortical activity, slower RTs, and broader neural recruitment across all frequency bands. Under combined load, OAs showed P3 latency prolongation, revealing vulnerability to the dual challenge of noise suppression and cognitive demand.</div></div><div><h3>Conclusion</h3><div>Integrated time- and frequency-domain electroencephalography analyses exposed distinct listening strategies in OAs, characterized by load-specific neural signatures.</div></div><div><h3>Significance</h3><div>Improved understanding of auditory processing strategies in OAs will advance targeted auditory rehabilitation.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111465"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145735500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical connectivity reorganization Induced by tDCS and Robotic-Assisted gait training in individuals with spinal cord injury 脊髓损伤患者tDCS和机器人辅助步态训练诱导的皮质连通性重组

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-24 DOI: 10.1016/j.clinph.2025.2111498

Daniel Boari Coelho , Artur Cesar Aquino dos Santos , Felipe Fregni , Linamara Rizzo Battistella

引用次数: 0

Sensory and motor cortical hyperexcitability in patients with amyotrophic lateral sclerosis: are they related? a prospective pilot study 肌萎缩性侧索硬化症患者的感觉和运动皮质亢进性：它们之间是否相关？一项前瞻性试点研究。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2026-01-02 DOI: 10.1016/j.clinph.2025.2111485

Giovanna Squintani , Marta Di Muzio , Andrea Rasera , Fabio Paio , Giovanni Umberto Borin , Kais Humaidan , Davide Orlando , Nicola Refatti , Silvia Romito , Michele Tinazzi , Bruno Bonetti , Mario Ermani

Objective

Our study evaluates sensory and motor cortical hyperexcitability as diagnostic biomarkers in ALS patients and investigates their relationship, identifying distinct or interconnected pathophysiological mechanisms in different sub-groups.

Methods

We examined 26 ALS patients and 18 healthy controls. Motor cortex excitability was assessed using transcranial magnetic stimulation to measure the motor evoked potential (MEP) suppression ratio. Somatosensory cortex excitability was evaluated through upper-limb somatosensory evoked potentials (SEPs) with conventional and paired-pulse techniques. Statistical analyses included parametric/non-parametric tests, correlation analyses, and χ² tests. ROC analysis was used to assess diagnostic performance. Significance threshold was p < 0.05.

Results

ALS patients showed a significantly reduced MEP suppression ratio (p < 0.001) with excellent discriminative power (100 % accuracy). SEP suppression ratio was significantly lower in ALS (p < 0.001), with sensitivity 76.3 %, specificity 91.7 %, and accuracy 84 %. In patients with giant SEPs, a strong inverse correlation was observed between MEP and SEP suppression ratios (r = − 0.70, p < 0.001).

Conclusions

MEP and SEP suppression ratio are robust biomarkers of motor cortical dysfunction in ALS patients with a highlighting cortical heterogeneity between sub-groups, suggesting cortical interconnection.

Significance

Alongside confirming motor and sensory cortical hyperexcitability as ALS hallmarks, this study reveals subgroup-specific patterns suggesting a compensatory interplay between sensory and motor cortex.

目的：本研究评估感觉和运动皮质高兴奋性作为ALS患者的诊断性生物标志物，并探讨它们之间的关系，确定不同亚组中不同或相互关联的病理生理机制。方法：选取26例ALS患者和18例健康对照。采用经颅磁刺激法测定运动诱发电位（MEP）抑制比，评估运动皮质兴奋性。采用常规和配对脉冲技术，通过上肢体感诱发电位（sep）评估躯体感觉皮层的兴奋性。统计分析包括参数/非参数检验、相关分析和χ2检验。采用ROC分析评估诊断表现。结果：肌萎缩侧索硬化症患者MEP抑制率显著降低(p)。结论：MEP和SEP抑制率是肌萎缩侧索硬化症患者运动皮质功能障碍的有力生物标志物，亚组间皮层异质性突出，提示皮层相互联系。意义：除了确认运动和感觉皮质亢奋是ALS的标志外，本研究还揭示了亚组特异性模式，提示感觉和运动皮质之间存在代偿性相互作用。

{"title":"Sensory and motor cortical hyperexcitability in patients with amyotrophic lateral sclerosis: are they related? a prospective pilot study","authors":"Giovanna Squintani , Marta Di Muzio , Andrea Rasera , Fabio Paio , Giovanni Umberto Borin , Kais Humaidan , Davide Orlando , Nicola Refatti , Silvia Romito , Michele Tinazzi , Bruno Bonetti , Mario Ermani","doi":"10.1016/j.clinph.2025.2111485","DOIUrl":"10.1016/j.clinph.2025.2111485","url":null,"abstract":"<div><h3>Objective</h3><div>Our study evaluates sensory and motor cortical hyperexcitability as diagnostic biomarkers in ALS patients and investigates their relationship, identifying distinct or interconnected pathophysiological mechanisms in different sub-groups.</div></div><div><h3>Methods</h3><div>We examined 26 ALS patients and 18 healthy controls. Motor cortex excitability was assessed using transcranial magnetic stimulation to measure the motor evoked potential (MEP) suppression ratio. Somatosensory cortex excitability was evaluated through upper-limb somatosensory evoked potentials (SEPs) with conventional and paired-pulse techniques. Statistical analyses included parametric/non-parametric tests, correlation analyses, and χ<sup>2</sup> tests. ROC analysis was used to assess diagnostic performance. Significance threshold was p < 0.05.</div></div><div><h3>Results</h3><div>ALS patients showed a significantly reduced MEP suppression ratio (p < 0.001) with excellent discriminative power (100 % accuracy). SEP suppression ratio was significantly lower in ALS (p < 0.001), with sensitivity 76.3 %, specificity 91.7 %, and accuracy 84 %. In patients with giant SEPs, a strong inverse correlation was observed between MEP and SEP suppression ratios (r = − 0.70, p < 0.001).</div></div><div><h3>Conclusions</h3><div>MEP and SEP suppression ratio are robust biomarkers of motor cortical dysfunction in ALS patients with a highlighting cortical heterogeneity between sub-groups, suggesting cortical interconnection.</div></div><div><h3>Significance</h3><div>Alongside confirming motor and sensory cortical hyperexcitability as ALS hallmarks, this study reveals subgroup-specific patterns suggesting a compensatory interplay between sensory and motor cortex.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111485"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory-evoked changes in slow oscillations and spindles correlate with memory consolidation in children with epilepsy and controls 听觉诱发的慢振荡和纺锤波的变化与癫痫和控制儿童的记忆巩固有关。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-07 DOI: 10.1016/j.clinph.2025.2111475

Hunki Kwon , Dhinakaran M. Chinappen , Anirudh Wodeyar , Elizabeth A. Kinard , Skyler K. Goodman , Wen Shi , Bryan S. Baxter , Dara S. Manoach , Mark A. Kramer , Catherine J. Chu

Objective

We investigated the effects of auditory stimulation during sleep on slow oscillations (SOs), SO-spindle complexes, and sleep-dependent memory consolidation in children with Rolandic Epilepsy (RE) and controls.

Methods

Participants completed two nap visits with auditory or sham stimulation. SOs and SO-spindle complexes rates were measured offline using validated detectors. Sleep-dependent memory consolidation was assessed using the motor sequence typing task.

Results

Auditory stimulation evoked SOs and SO-spindle complexes with maximal effect over frontal electrodes. Compared to sham, stimulation of background activity increased SOs (29.8 %, p < 0.001) and SO-spindle complexes (16.8 %, p < 0.001); stimulation of an ongoing SO upstate maximally evoked SOs (51.3 % increase, p < 0.001) and SO-spindle complexes (32.3 % increase, p < 0.001). Changes in frontal SO (1.9 % improvement per increase in SO/min; p < 0.001) and SO-spindle complexes (9.5 % improvement per increase in SO-spindle/min; p = 0.007) event rates due to auditory stimulation positively predicted changes in sleep-dependent memory consolidation.

Conclusion

Auditory stimulation reliably modulates sleep oscillations when delivered on background activity and during the upstate of SOs. As increased event rates improve memory consolidation, stimulation paradigms to increase SO and SO-spindle complex rates are required to enhance memory.

Significance

Auditory stimulation paradigms that increase SO and SO-spindle complex rates may enhance sleep-dependent memory consolidation.

目的：探讨睡眠时听觉刺激对罗兰dic癫痫（RE）患儿及对照组慢振荡（so）、慢梭形复合体和睡眠依赖性记忆巩固的影响。方法：参与者在听觉或假刺激下完成两次午睡访问。使用经过验证的检测器离线测量SOs和so纺锤体配合物速率。通过运动序列输入任务评估睡眠依赖性记忆巩固。结果：听觉刺激诱发的SOs和so纺锤体复合物在额电极上的作用最大。与假手术相比，背景活动刺激增加了SOs（29.8%）。结论：听觉刺激在背景活动和SOs上状态时可靠地调节睡眠振荡。由于增加的事件率促进记忆巩固，因此需要增加SO和SO-纺锤体复合体率的刺激范式来增强记忆。意义：听觉刺激范式增加梭形和梭形纺锤体复合体速率可能促进睡眠依赖性记忆巩固。

{"title":"Auditory-evoked changes in slow oscillations and spindles correlate with memory consolidation in children with epilepsy and controls","authors":"Hunki Kwon , Dhinakaran M. Chinappen , Anirudh Wodeyar , Elizabeth A. Kinard , Skyler K. Goodman , Wen Shi , Bryan S. Baxter , Dara S. Manoach , Mark A. Kramer , Catherine J. Chu","doi":"10.1016/j.clinph.2025.2111475","DOIUrl":"10.1016/j.clinph.2025.2111475","url":null,"abstract":"<div><h3>Objective</h3><div>We investigated the effects of auditory stimulation during sleep on slow oscillations (SOs), SO-spindle complexes, and sleep-dependent memory consolidation in children with Rolandic Epilepsy (RE) and controls.</div></div><div><h3>Methods</h3><div>Participants completed two nap visits with auditory or sham stimulation. SOs and SO-spindle complexes rates were measured offline using validated detectors. Sleep-dependent memory consolidation was assessed using the motor sequence typing task.</div></div><div><h3>Results</h3><div>Auditory stimulation evoked SOs and SO-spindle complexes with maximal effect over frontal electrodes. Compared to sham, stimulation of background activity increased SOs (29.8 %, p < 0.001) and SO-spindle complexes (16.8 %, p < 0.001); stimulation of an ongoing SO upstate maximally evoked SOs (51.3 % increase, p < 0.001) and SO-spindle complexes (32.3 % increase, p < 0.001). Changes in frontal SO (1.9 % improvement per increase in SO/min; p < 0.001) and SO-spindle complexes (9.5 % improvement per increase in SO-spindle/min; p = 0.007) event rates due to auditory stimulation positively predicted changes in sleep-dependent memory consolidation.</div></div><div><h3>Conclusion</h3><div>Auditory stimulation reliably modulates sleep oscillations when delivered on background activity and during the upstate of SOs. As increased event rates improve memory consolidation, stimulation paradigms to increase SO and SO-spindle complex rates are required to enhance memory.</div></div><div><h3>Significance</h3><div>Auditory stimulation paradigms that increase SO and SO-spindle complex rates may enhance sleep-dependent memory consolidation.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111475"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145818309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to “Revisiting the accuracy of motor evoked potential determination: The overlooked role of surface electrode montage” 回复“重新审视运动诱发电位测定的准确性：表面电极蒙太奇被忽视的作用”。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-17 DOI: 10.1016/j.clinph.2025.2111481

Marten Nuyts , Stefanie Verstraelen , Joana Frieske , Raf Meesen , Sybren Van Hoornweder

引用次数: 0

Motor evoked potentials as a side effect biomarker for deep brain stimulation 运动诱发电位作为深部脑刺激的副作用生物标志物

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-24 DOI: 10.1016/j.clinph.2025.2111499

Paola Testini , Austin Wang , Eric R. Cole , Svjetlana Miocinovic

Objectives

To determine if motor evoked potentials (MEP) – stimulation-induced muscle activation measured using electromyography – can serve as a biomarker of corticobulbar (CBT) and corticospinal (CST) tract activation induced by deep brain stimulation (DBS).

Methods

In 12 patients with Parkinson’s disease and subthalamic (n = 10) or pallidal (n = 2) DBS, contact mapping determined clinical motor side effect thresholds. For equivalent stimulation parameters (except lower frequency), EMG was recorded from cranial and arm muscles to determine the presence, peak amplitudes and latencies of MEP. Clinical side effect and MEP thresholds were compared and accuracy metrics calculated.

Results

The MEP amplitudes increased with stimulation intensity. Latencies were shorter for cranial muscles, which were also more likely to generate an MEP. Clinical side effect and MEP thresholds were significantly correlated (R² = 0.31; p = 0.0006), although most MEP thresholds were lower than side effect thresholds. The MEP accuracy in predicting side effects was 0.72, with a sensitivity of 0.68 and a specificity of 0.73.

Conclusions

MEP thresholds correlated with side effect thresholds but were often lower indicating subclinical CBT/CST activations.

Significance

This study characterizes motor potentials evoked by DBS and demonstrates their potential utility as an objective biomarker for motor side effect detection during DBS programming.

目的确定运动诱发电位(MEP) -使用肌电图测量刺激诱导的肌肉激活-是否可以作为脑深部刺激（DBS）诱导的皮质球束（CBT）和皮质脊髓束（CST）激活的生物标志物。方法对12例伴有丘脑下丘脑DBS （n = 10）或pallial DBS （n = 2）的帕金森病患者进行接触映射，确定临床运动副作用阈值。对于等效的刺激参数（低频除外），记录颅骨和手臂肌肉的肌电图，以确定MEP的存在、峰值振幅和潜伏期。比较临床副作用和MEP阈值并计算准确性指标。结果MEP振幅随刺激强度的增大而增大。颅肌的潜伏期较短，也更容易产生MEP。临床副作用与MEP阈值显著相关（R2 = 0.31; p = 0.0006），但大多数MEP阈值低于副作用阈值。MEP预测副作用的准确度为0.72，敏感性为0.68，特异性为0.73。结论smep阈值与不良反应阈值相关，但通常较低表明亚临床CBT/CST激活。本研究表征了DBS诱发的运动电位，并证明了它们作为DBS编程过程中运动副作用检测的客观生物标志物的潜在用途。

{"title":"Motor evoked potentials as a side effect biomarker for deep brain stimulation","authors":"Paola Testini , Austin Wang , Eric R. Cole , Svjetlana Miocinovic","doi":"10.1016/j.clinph.2025.2111499","DOIUrl":"10.1016/j.clinph.2025.2111499","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine if motor evoked potentials (MEP) – stimulation-induced muscle activation measured using electromyography – can serve as a biomarker of corticobulbar (CBT) and corticospinal (CST) tract activation induced by deep brain stimulation (DBS).</div></div><div><h3>Methods</h3><div>In 12 patients with Parkinson’s disease and subthalamic (n = 10) or pallidal (n = 2) DBS, contact mapping determined clinical motor side effect thresholds. For equivalent stimulation parameters (except lower frequency), EMG was recorded from cranial and arm muscles to determine the presence, peak amplitudes and latencies of MEP. Clinical side effect and MEP thresholds were compared and accuracy metrics calculated.</div></div><div><h3>Results</h3><div>The MEP amplitudes increased with stimulation intensity. Latencies were shorter for cranial muscles, which were also more likely to generate an MEP. Clinical side effect and MEP thresholds were significantly correlated (R<sup>2</sup> = 0.31; p = 0.0006), although most MEP thresholds were lower than side effect thresholds. The MEP accuracy in predicting side effects was 0.72, with a sensitivity of 0.68 and a specificity of 0.73.</div></div><div><h3>Conclusions</h3><div>MEP thresholds correlated with side effect thresholds but were often lower indicating subclinical CBT/CST activations.</div></div><div><h3>Significance</h3><div>This study characterizes motor potentials evoked by DBS and demonstrates their potential utility as an objective biomarker for motor side effect detection during DBS programming.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111499"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of corticospinal excitability by paired associative stimulation following stroke 脑卒中后成对联想刺激对皮质脊髓兴奋性的调节

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-06 DOI: 10.1016/j.clinph.2025.2111474

Alona Ron Levy , Iuly Treger , Uri Alyagon , Tatiana Gulevsky , Noam Ygael , Amit Hiedemann , Olga Nachliely , Orna Kohav , Judith S. Nosgorodsky , Alan Friedman , Lena Lutsky , Jechil S. Sieratzki , Abraham Zangen

引用次数: 0

Reduced neural speech tracking in adolescents with listening difficulty 听力障碍青少年的神经语言追踪功能降低

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2026-01-02 DOI: 10.1016/j.clinph.2026.2111502

Katsuaki Kojima , Chunyan Liu , Shelley Ehrlich , Harvey Dillon , Chelsea Blankenship , Lina Motlagh Zadeh , Jennifer Vannest , Lisa Hunter , Srikantan Nagarajan , David R. Moore

Objective

To investigate neural mechanisms underlying speech-in-speech listening in adolescents with listening difficulties (LiD).

Methods

Neural speech tracking (NST) was assessed using magnetoencephalography (MEG; 275 sensors) in 21 adolescents with LiD (11 females), identified by caregiver report, and 25 typically developing (TD) peers (10 females), all with normal audiograms and frequency-matched on age, sex, race, and ethnicity. Participants completed a cocktail-party task with target speech alone and with competing streams that varied in talker and spatial cues. NST was quantified using theta-band (4–8 Hz) inter-event phase coherence (IEPC) to acoustic edges.

Results

Adolescents with LiD showed reduced target-speech NST relative to TD peers, with comparable competitor tracking. Theta-band IEPC correlated with listening ability (partial R² = 0.10; p = 0.037). Concurrent talker and spatial cues synergistically enhanced target-speech NST, especially in TD adolescents, but not competitor streams.

Conclusions

LiD is characterized by impaired processing of attended speech rather than enhanced competitor processing or generalized auditory disengagement. Reduced integration of talker and spatial cues in LiD may contribute to real-world listening challenges.

Significance

Theta‑band NST provides a clinically relevant neural index of everyday listening and may guide interventions targeting selective attention and cue integration.

目的探讨听力障碍青少年语中听的神经机制。方法采用脑磁图（MEG； 275个传感器）对21名青少年（11名女性）和25名正常发育（TD）同龄人（10名女性）的神经语音跟踪（NST）进行评估，这些青少年的听力图正常，年龄、性别、种族和民族的频率匹配。参与者完成了一项鸡尾酒会任务，其中有单独的目标演讲，也有在说话者和空间线索上不同的竞争流。利用theta波段（4-8 Hz）到声学边缘的事件间相位相干性（IEPC）对NST进行量化。结果在竞争对手跟踪方面，低语言障碍青少年的目标言语NST水平低于低语言障碍同龄人。θ波段IEPC与听力能力相关（偏R2 = 0.10; p = 0.037）。同时说话者和空间线索协同增强了目标言语NST，特别是在TD青少年中，但没有竞争者线索。结论滑脱的特点是参与言语加工受损，而非竞争对手加工增强或广义听觉脱离。在LiD中，说话者和空间线索的整合减少可能会导致现实听力挑战。theta - band NST提供了临床相关的日常听力神经指标，可以指导针对选择性注意和线索整合的干预措施。

{"title":"Reduced neural speech tracking in adolescents with listening difficulty","authors":"Katsuaki Kojima , Chunyan Liu , Shelley Ehrlich , Harvey Dillon , Chelsea Blankenship , Lina Motlagh Zadeh , Jennifer Vannest , Lisa Hunter , Srikantan Nagarajan , David R. Moore","doi":"10.1016/j.clinph.2026.2111502","DOIUrl":"10.1016/j.clinph.2026.2111502","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate neural mechanisms underlying speech-in-speech listening in adolescents with listening difficulties (LiD).</div></div><div><h3>Methods</h3><div>Neural speech tracking (NST) was assessed using magnetoencephalography (MEG; 275 sensors) in 21 adolescents with LiD (11 females), identified by caregiver report, and 25 typically developing (TD) peers (10 females), all with normal audiograms and frequency-matched on age, sex, race, and ethnicity. Participants completed a cocktail-party task with target speech alone and with competing streams that varied in talker and spatial cues. NST was quantified using theta-band (4–8 Hz) inter-event phase coherence (IEPC) to acoustic edges.</div></div><div><h3>Results</h3><div>Adolescents with LiD showed reduced target-speech NST relative to TD peers, with comparable competitor tracking. Theta-band IEPC correlated with listening ability (partial R<sup>2</sup> = 0.10; p = 0.037). Concurrent talker and spatial cues synergistically enhanced target-speech NST, especially in TD adolescents, but not competitor streams.</div></div><div><h3>Conclusions</h3><div>LiD is characterized by impaired processing of attended speech rather than enhanced competitor processing or generalized auditory disengagement. Reduced integration of talker and spatial cues in LiD may contribute to real-world listening challenges.</div></div><div><h3>Significance</h3><div>Theta‑band NST provides a clinically relevant neural index of everyday listening and may guide interventions targeting selective attention and cue integration.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111502"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0