Clinical Neurophysiology最新文献_第5页

Nerve ultrasound in asymptomatic hereditary transthyretin amyloidosis carriers 无症状遗传性甲状腺转蛋白淀粉样变携带者的神经超声检查

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-20 DOI: 10.1016/j.clinph.2025.2111446

Wilder-Smith E , Tournev I , Chamova T , Asenov O , Bohlhalter S , Antimov P , Mihaylova V

Objective

The aim of our study was to perform high-resolution nerve ultrasound in asymptomatic carriers of transthyretin (TTR) p.Glu89Gln (p.Glu109Gln) mutation and to evaluate its role as a complementary non-invasive diagnostic tool in early detection of amyloid deposits in peripheral nerves.

Methods

The study included 21 asymptomatic carriers of TTR p.Glu89Gln (p.Glu109Gln). History, neurological examination, nerve conduction studies, sympathetic skin response, SudoScan and high-resolution nerve ultrasound were performed.

Results

Ultrasound pattern sum score was abnormal in 70% of the carriers. Despite the younger age of male carriers compared to the female carriers the abnormal ultrasound findings were more frequently encountered in males. The latter also demonstrated more pronounced cross-sectional area enlargement of the peroneal nerve at the fibular head and had more frequently ultrasound evidence of median nerve swelling at the wrist. Sural nerves were not enlarged in contrast to radial and fibular superficial nerves which showed male preponderance.

Conclusions

Our data suggest early ultrasound detection of amyloid deposition in presymptomatic TTR p. Glu89Gln (p.Glu109Gln) carriers and demonstrated sex related differences with earlier amyloid deposition in male carriers.

Significance

As a non-invasive tool nerve ultrasound may be added to the established follow up program for the asymptomatic TTR carriers.

目的对无症状转甲状腺素（TTR） p.Glu89Gln （p.Glu109Gln）突变携带者进行高分辨率神经超声检查，并评价其作为一种辅助的非侵入性诊断工具在早期检测周围神经淀粉样蛋白沉积中的作用。方法选取21例无症状TTR p.Glu89Gln （p.Glu109Gln）携带者。进行病史、神经学检查、神经传导研究、交感皮肤反应、SudoScan和高分辨率神经超声检查。结果70%的携带者超声模式综合评分异常。尽管男性携带者比女性携带者年龄小，但异常超声结果在男性中更常见。后者也表现出腓骨头腓神经更明显的横截面积扩大，并且在手腕处有更频繁的正中神经肿胀的超声证据。腓肠神经没有扩张，而桡骨和腓骨浅神经则以男性为主。结论早期超声可检出TTR p. Glu89Gln （p. glu109gln）症状前携带者的淀粉样蛋白沉积，且与男性携带者的早期淀粉样蛋白沉积存在性别差异。意义：神经超声作为一种无创工具，可加入到已建立的无症状TTR携带者随访计划中。

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引用次数: 0

Hemispheric asymmetry of the ipsilateral silent period following voluntary movement of the opposite hand 另一只手自主运动后同侧沉默期的半球不对称。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-19 DOI: 10.1016/j.clinph.2025.2111444

Sabira Alibhai-Najarali , John P. de Grosbois , Aaron E. Philipp-Muller , Jennifer Shao , Matthew J. Hawken , Matea Skenderija , Jed A. Meltzer

Objective

To investigate whether post-movement beta rebound (PMBR), a proposed marker of cortical inhibition, reflects interhemispheric inhibition as measured by the ipsilateral silent period (iSP) following voluntary movement and to assess hemispheric asymmetries.

Methods

Twenty right-handed participants underwent transcranial magnetic stimulation (TMS) to elicit iSPs at baseline (no button-press) and eight timepoints following movement of the opposite hand, iSPs and motor-evoked potentials (MEPs) were recorded for both hemispheres. Six participants completed magnetoencephalography (MEG) to characterize beta oscillatory activity during the task. Five participants completed the task without the TMS as a control.

Results

iSP magnitude did not significantly change during PMBR period. Instead, post-movement iSP increased in the right hemisphere and decreased in the left, yielding a significant hemispheric difference (p = 0.014). MEG data confirmed symmetrical PMBR across hemispheres. MEPs showed increased excitability post-movement, particularly at early timepoints. Movement alone, without TMS, did not account for hemispheric asymmetry.

Conclusions

PMBR and iSP appear to reflect distinct inhibitory mechanisms. The dissociation suggests PMBR does not index transcallosal inhibition (TCI). Hemispheric asymmetry in iSP suggests stronger TCI following non-dominant hand movements.

Significance

The dissociation between iSP and PMBR underscores the complexity of motor control, informs understanding lateralized motor function and rehabilitation.

目的：研究运动后β反弹（PMBR），一种被提出的皮层抑制标志物，是否反映了自主运动后同侧沉默期（iSP）测量的半球间抑制，并评估半球不对称性。方法：采用经颅磁刺激（TMS）诱发20名右撇子参与者在基线（不按按钮）和对侧手运动后8个时间点的iSPs，记录双脑的iSPs和运动诱发电位（MEPs）。六名参与者完成了脑磁图（MEG）来表征任务期间的β振荡活动。五名参与者在没有经颅磁刺激作为对照的情况下完成了任务。结果：PMBR期间iSP大小无明显变化。相反，运动后的iSP在右半球增加，在左半球减少，产生显著的半球差异（p = 0.014）。脑磁图数据证实了跨半球的对称PMBR。mep在运动后表现出兴奋性增强，尤其是在早期。单独运动，不经颅磁刺激，不能解释半球不对称。结论：PMBR和iSP似乎反映了不同的抑制机制。分离表明PMBR不能反映经胼胝体抑制（TCI）。iSP的半球不对称表明非优势手运动后TCI增强。意义：iSP和PMBR之间的分离强调了运动控制的复杂性，有助于理解侧化运动功能和康复。

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引用次数: 0

Youth with essential tremor differ from age-matched controls in multiple aspects of visually-guided reaching movements 患有特发性震颤的青少年在视觉引导的伸手动作的多个方面与年龄匹配的对照组不同

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-19 DOI: 10.1016/j.clinph.2025.2111445

Nicholas Cothros , Catherine Lowrey , Stephen H. Scott , Alex Medina Escobar , Sean Dukelow , Davide Martino , Tamara Pringsheim

Objective

Essential tremor (ET) likely includes deficits outside tremor, though this is under-examined in youth. We tested the hypothesis that reaching movements in youth with ET are characterized by greater incoordination.

Methods

Fifteen youth with ET (ages 11 to 17) recruited from the Calgary Tourette and Pediatric Movement Disorders Clinic completed a visually-guided reaching task using the Kinarm Exoskeleton Lab. Performance in several kinematic parameters was compared with age-matched controls.

Results

Youth with ET differed from controls in multiple parameters. In the dominant arm, the initial portion of reaching movements was slower and smaller-amplitude, with longer reaction time and greater posture speed at movement end when the hand should be at rest. In the non-dominant arm, those with ET differed from controls in a larger number of parameters. All but three with ET were impaired in at least one task parameter, scoring outside age-predicted norms.

Conclusion

Our study supports the notion of ET as a disorder with abnormalities beyond tremor, and that motoric abnormalities are demonstrable in youth with ET.

Significance

This is the first study showing youth with ET differ from age-matched controls in multiple aspects of reaching movements, including initial trajectory control, movement smoothness, overall trajectory, and endpoint control.

目的特发性震颤（ET）可能包括震颤以外的缺陷，尽管这在青少年中尚未得到充分研究。我们测试了一个假设，即ET青少年的伸展运动的特点是更大的不协调。方法从卡尔加里抽动秽语和儿童运动障碍诊所招募了15名ET青少年（11至17岁），使用Kinarm外骨骼实验室完成了一项视觉引导的到达任务。将几个运动学参数的表现与年龄匹配的对照组进行比较。结果ET患儿与对照组在多个参数上存在差异。优势臂到达动作的起始部分速度较慢，幅度较小，动作结束时反应时间较长，动作结束时姿态速度较大。在非优势组中，ET患者在许多参数上与对照组不同。除了三个外，所有ET患者在至少一个任务参数上都受损，得分超出了年龄预测标准。结论：我们的研究支持ET是一种除震颤外的异常疾病的观点，并且运动异常在ET的青少年中是明显的。意义：这是第一个研究表明ET的青少年在到达运动的多个方面与年龄匹配的对照组不同，包括初始轨迹控制、运动平滑度、总体轨迹和终点控制。

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引用次数: 0

Between Mind and Movement: Electrophysiological insights into functional dystonia 在意识和运动之间：功能性肌张力障碍的电生理学见解

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-17 DOI: 10.1016/j.clinph.2025.2111442

Alexey Sedov , Ulia Semenova , Anna Gamaleya , Alexey Tomskiy , Aasef G. Shaikh

引用次数: 0

Intraoperative Ultrasound-Assisted 3D-Electrocorticography for resection of type II focal cortical dysplasias 术中超声辅助3d皮质电成像切除II型局灶性皮质发育不良

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-17 DOI: 10.1016/j.clinph.2025.2111443

Giuseppe Didato , Nicolò Castelli , Chiara Pastori , Paola Lanteri , Ambra Dominese , Michele Introna , Rita Garbelli , Fabio Martino Doniselli , Gianluca Marucci , Elena Freri , Angelo Del Sole , Valeria Cuccarini , Francesco Deleo , Andrea Stabile , Roberta Di Giacomo , Francesca Ragona , Laura Rossini , Carla Carozzi , Massimiliano Del Bene , Vittoria Nazzi , Michele Rizzi

Objective

Type II focal cortical dysplasias (FCDII) present a clear-cut anatomo-electro-clinical profile and are associated with optimal surgical outcome when completely resected. Alongside presurgical planning and neuroimaging, intraoperative electrocorticography (ECoG) can aid in delineating FCDII boundaries. We report outcomes from patients undergoing FCDII resection using 3D-ECoG with an intracerebral electrode guided by intraoperative ultrasound (ioUS).

Methods

Patients with suspected FCDII underwent 3D-ECoG during surgery to record intracerebral interictal epileptiform discharges (IEDs) classified as: 1) rhythmic spikes (RS), and 2) periodic bursts of polyspikes (PBOP).

Results

Ten patients (5 male, 5 female; median age 19.5 years, median epilepsy duration 16 years) were included. Bottom-of-sulcus dysplasia (BOSD) was found in 60 %. 3D-ECoG identified RS in 30 % and PBOP in 70 %. Total IED removal was achieved in 60 %. Histopathology revealed FCDII in 80 %, while 20 % had a diagnosis of “no definite FCD on histopathology”. After a median 24-month follow-up, 90 % achieved ILAE class 1 outcome (seizure free), 10 % had class 2 (only auras). No major complications occurred.

Conclusions

IoUS-assisted 3D-ECoG is a safe procedure for intraoperative delineation of FCDII, supporting complete resection.

Significance

Integrating IoUS with 3D-ECoG can offer substantial benefits for surgical management of FCDII-related epilepsy.

目的II型局灶性皮质发育不良（FCDII）具有明确的解剖-电-临床特征，并与完全切除后的最佳手术结果相关。除了术前计划和神经成像外，术中皮质电图（ECoG）可以帮助划定FCDII边界。我们报告了术中超声（iou）引导下脑内电极3D-ECoG切除FCDII患者的结果。方法疑似FCDII患者术中行3D-ECoG记录脑内癫痫样间期放电（IEDs），分为：1)节律性尖峰（RS）和2)多尖峰周期性爆发（PBOP）。结果纳入患者10例，男5例，女5例，中位年龄19.5岁，中位癫痫持续时间16年。沟底发育不良（BOSD）占60%。3D-ECoG鉴定RS为30%，PBOP为70%。总IED清除率为60%。组织病理学检查显示FCDII的占80%，而20%的组织病理学诊断为“没有明确的FCD”。中位随访24个月后，90%达到ILAE 1级结果（无癫痫发作），10%达到2级结果（仅有先兆）。无重大并发症发生。结论辅助3D-ECoG是术中描绘FCDII的安全方法，支持完全切除。意义将借据与3D-ECoG相结合可以为fcdii相关癫痫的手术治疗提供实质性的好处。

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引用次数: 0

Modulating altered sensory prediction using bilateral auditory cortex high-definition transcranial random noise stimulation and acoustic masking 利用双侧听觉皮层高清晰度经颅随机噪声刺激和声掩蔽调节改变的感觉预测。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-16 DOI: 10.1016/j.clinph.2025.2111388

Zino H. Wellauer , Deniza Avdi , Payam S. Shabestari , Allegra Preisig , Jessica Fritzsche , Nicole Peter , Martin Meyer , Tobias Kleinjung , Patrick K.A. Neff

Objective:

To assess the combined effect of high-definition transcranial random noise stimulation (HD-tRNS) of bilateral auditory cortex and acoustic stimulation (AS) on auditory evoked potentials and tinnitus perception.

Methods:

A double-blind, randomized, controlled, within-subject crossover trial was conducted with thirteen adults with chronic tinnitus. Each participant completed four sessions, at least 48 h apart, consisting of active HD-tRNS + AS, active HD-tRNS alone, sham HD-tRNS + sham AS and sham HD-tRNS alone. Auditory evoked potentials (including mismatch negativity) and tinnitus characteristics were measured before and after each session.

Results:

Active electric and bimodal stimulation significantly modulated auditory evoked potentials, unlike their sham equivalents. Bimodal stimulation produced significant changes in MMN amplitude that countered the tinnitus-related alteration in processing intensity deviants. However, these effects did not survive family-wise correction in this complex design. Bimodal and bimodal-sham stimulation reduced objective loudness by >3 dB.

Conclusion:

HD-tRNS, particularly when combined with AS, may induce changes in auditory-system excitability and acutely alter neural processing and loudness perception in tinnitus.

Significance:

Combining acoustic and electric stimulation is a promising approach for basic research and clinical applications in auditory neuroscience, providing new insights into neuroplasticity in an altered auditory system. This is the first study to measure the modifiability of evoked neural correlates in tinnitus.

目的：探讨双侧听觉皮层高清晰度经颅随机噪声刺激（HD-tRNS）和声刺激（AS）对听觉诱发电位和耳鸣感知的联合影响。方法：对13例成人慢性耳鸣患者进行双盲、随机、对照、组内交叉试验。每个参与者完成四个疗程，间隔至少48小时，包括活性HD-tRNS + AS、单独活性HD-tRNS、假HD-tRNS +假AS和单独假HD-tRNS。每次训练前后分别测量听觉诱发电位（包括错配负性）和耳鸣特征。结果：与假刺激不同，主动电刺激和双峰刺激显著调节了听觉诱发电位。双峰刺激产生了MMN振幅的显著变化，抵消了耳鸣相关的加工强度偏差的改变。然而，在这个复杂的设计中，这些影响并没有在家庭明智的纠正中幸存下来。双峰刺激和双峰-假刺激使客观响度降低bb30 dB。结论：HD-tRNS，特别是与AS合并时，可引起耳鸣患者听觉系统兴奋性的改变，并严重改变耳鸣患者的神经加工和响度感知。意义：声电结合刺激是听觉神经科学基础研究和临床应用的一种有前景的方法，为听觉系统改变中的神经可塑性提供了新的见解。这是第一个测量耳鸣中诱发神经相关物可变性的研究。

{"title":"Modulating altered sensory prediction using bilateral auditory cortex high-definition transcranial random noise stimulation and acoustic masking","authors":"Zino H. Wellauer , Deniza Avdi , Payam S. Shabestari , Allegra Preisig , Jessica Fritzsche , Nicole Peter , Martin Meyer , Tobias Kleinjung , Patrick K.A. Neff","doi":"10.1016/j.clinph.2025.2111388","DOIUrl":"10.1016/j.clinph.2025.2111388","url":null,"abstract":"<div><h3>Objective:</h3><div>To assess the combined effect of high-definition transcranial random noise stimulation (HD-tRNS) of bilateral auditory cortex and acoustic stimulation (AS) on auditory evoked potentials and tinnitus perception.</div></div><div><h3>Methods:</h3><div>A double-blind, randomized, controlled, within-subject crossover trial was conducted with thirteen adults with chronic tinnitus. Each participant completed four sessions, at least 48 h apart, consisting of active HD-tRNS + AS, active HD-tRNS alone, sham HD-tRNS + sham AS and sham HD-tRNS alone. Auditory evoked potentials (including mismatch negativity) and tinnitus characteristics were measured before and after each session.</div></div><div><h3>Results:</h3><div>Active electric and bimodal stimulation significantly modulated auditory evoked potentials, unlike their sham equivalents. Bimodal stimulation produced significant changes in MMN amplitude that countered the tinnitus-related alteration in processing intensity deviants. However, these effects did not survive family-wise correction in this complex design. Bimodal and bimodal-sham stimulation reduced objective loudness by >3 dB.</div></div><div><h3>Conclusion:</h3><div>HD-tRNS, particularly when combined with AS, may induce changes in auditory-system excitability and acutely alter neural processing and loudness perception in tinnitus.</div></div><div><h3>Significance:</h3><div>Combining acoustic and electric stimulation is a promising approach for basic research and clinical applications in auditory neuroscience, providing new insights into neuroplasticity in an altered auditory system. This is the first study to measure the modifiability of evoked neural correlates in tinnitus.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111388"},"PeriodicalIF":3.6,"publicationDate":"2025-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145602214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG-based stratification in Alzheimer’s disease: Cognitive progression, pathological marker associations, and therapeutic interventions 基于脑电图的阿尔茨海默病分层：认知进展、病理标志物关联和治疗干预

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-15 DOI: 10.1016/j.clinph.2025.2111440

Zian Pei , Lin Zhu , Huixia Ren , Yumei Liu , Xue Shi , Yun Lin , Jing Wang , Pan Li , Pan Wang , Yong Ji , Yuying Zhou , Xiaoying Tang , Xin Jiang , Xiaoguang Tong , Yi Guo

Objective

Clinical cognitive and pathological marker stratification systems have evolved separately, causing mismatches that limit their clinical use. This study retrospectively validated the link between EEG and clinical symptoms, pathological markers, and the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS).

Methods

This multicenter study involved 308 Alzheimer’s patients (AD), 176 with Parkinson’s (PD), and 181 normal controls. Resting-state EEG were analyzed to identify four oscillation modes. An EEG-based cognitive risk system was created and validated, also evaluating its effect on rTMS therapy effectiveness.

Results

EEG oscillation changes correlated with cognitive decline, revealing distinct brain network disruptions in AD and PD. These oscillation changes were associated with AD biomarkers, particularly tau hyperphosphorylation. Multicenter validation showed an 83% concordance with the Clinical Dementia Rating Scale, and EEG stratification enhanced rTMS therapeutic efficacy.

Conclusions

This study showed that EEG-based stratification can assess cognitive function, track disease progression, identify key intervention periods, and improve patient selection for better treatment outcomes in clinical settings.

Significance

This study demonstrates that EEG can connect disease processes to clinical symptoms at a molecular level, offering a unified framework for improved dementia management. This method allows for dynamic monitoring and precise neuromodulation, enhancing personalized care for neurodegenerative diseases.

临床认知和病理标记物分层系统已经分开发展，导致不匹配，限制了它们的临床应用。本研究回顾性地验证了脑电图与临床症状、病理标志物和重复经颅磁刺激（rTMS）治疗效果之间的联系。方法本研究纳入308例阿尔茨海默病（AD）患者、176例帕金森病（PD）患者和181例正常对照。静息状态脑电图分析确定了四种振荡模式。建立并验证了基于脑电图的认知风险系统，并评估了其对rTMS治疗效果的影响。结果seeg振荡变化与认知能力下降相关，揭示了AD和PD患者明显的脑网络中断。这些振荡变化与AD生物标志物有关，特别是tau过度磷酸化。多中心验证显示与临床痴呆评定量表的一致性为83%，脑电图分层增强了rTMS的治疗效果。结论：基于脑电图的分层可以评估认知功能，跟踪疾病进展，确定关键干预期，改善患者选择，以获得更好的临床治疗效果。本研究表明脑电图可以在分子水平上将疾病过程与临床症状联系起来，为改善痴呆管理提供统一的框架。这种方法允许动态监测和精确的神经调节，加强对神经退行性疾病的个性化护理。

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引用次数: 0

Decoding alzheimer’s: The role of EEG rhythms and aperiodic components in cognitive decline 解码阿尔茨海默病：脑电图节律和非周期性成分在认知衰退中的作用

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-13 DOI: 10.1016/j.clinph.2025.2111437

Mingyang Zhang , Xia Liu , Yanan Ren , Lixuan Li , Ruoyu Wang , Lihui Sun , Qinying Ma

Objective

To investigate detailed alterations in brain electrical activity and their relationship with cognitive decline in Alzheimer’s disease (AD) using electroencephalogram (EEG) power spectrum analysis.

Methods

EEG data from 80 AD patients and 80 healthy control (HC) were analyzed, focusing on theta and alpha band powers, aperiodic offset, and exponent. Topographic and gender-specific analyses were conducted to explore associations with disease progression and cognitive impairment.

Results

AD patients showed increased theta and alpha band powers, with theta band power exhibiting statistically significant differences. Globally elevated theta band power correlated with cognitive impairment severity. Higher aperiodic offsets and exponents were observed in AD patients, exhibiting upward trends with disease progression. Male AD patients displayed more pronounced EEG abnormalities and unique Montreal Cognitive Assessment (MOCA) score patterns.

Conclusions

Our findings highlight the critical role of theta band power in AD pathology and suggest potential EEG biomarkers for neurodegenerative changes. Gender-specific differences emphasize the importance of personalized approaches in AD diagnosis and treatment.

Significance

This study provides novel neurophysiological insights into AD, underscoring the clinical utility of EEG markers and the necessity for gender-specific considerations in precision medicine for AD.

目的利用脑电图（EEG）功率谱分析阿尔茨海默病（AD）脑电活动的详细变化及其与认知能力下降的关系。方法对80例AD患者和80例健康对照（HC）的seeg数据进行分析，重点分析theta和alpha波段功率、非周期偏移和指数。进行地形和性别分析，以探讨疾病进展和认知障碍的关系。结果ad患者theta和alpha波段功率均升高，其中theta波段功率差异有统计学意义。整体θ波段功率升高与认知障碍严重程度相关。在AD患者中观察到较高的非周期性偏移和指数，随着疾病进展呈现上升趋势。男性AD患者表现出更明显的脑电图异常和独特的蒙特利尔认知评估（MOCA）评分模式。结论我们的研究结果强调了θ波段功率在AD病理中的关键作用，并提示了神经退行性改变的潜在EEG生物标志物。性别差异强调了AD诊断和治疗中个性化方法的重要性。这项研究为阿尔茨海默病提供了新的神经生理学见解，强调了脑电图标志物的临床应用，以及在阿尔茨海默病的精准医学中考虑性别的必要性。

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引用次数: 0

Temporal dynamics of electroconvulsive therapy induced seizures 电痉挛疗法诱发癫痫发作的时间动力学。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-12 DOI: 10.1016/j.clinph.2025.2111439

Sven Stuiver , Prejaas K.B. Tewarie , Julia C.M. Pottkämper , Joey P.A.J. Verdijk , Michel J.A.M. van Putten , Jeannette Hofmeijer , Jeroen A. van Waarde

Objective

Electroconvulsive therapy (ECT) is an effective treatment for several psychiatric disorders. The role of cortex and thalamus in seizure expression and termination seems critical. Here we study spatiotemporal dynamics of ECT-induced seizures based on electroencephalogram (EEG) features and biophysical parameters using a corticothalamic mean-field model.

Methods

We analyzed 345 ictal EEGs from 33 patients (19 female). EEG features included the dominant frequency, and temporal and spatial correlations. A corticothalamic biophysical model assessed cortical excitation/inhibition (E/I) balance and effective corticothalamic and intrathalamic loop strengths. We tracked the temporal evolution of each feature and parameter from seizure onset to termination.

Results

ECT-induced seizures showed EEG slowing (i.e., a decrease in dominant frequency) and increased temporal correlations as seizures approached termination. Cortical E/I ratios and corticothalamic loop strength increased, while intrathalamic strength decreased. Both EEG slowing and increase in temporal correlations were associated with increased cortical E/I ratios and decreased intrathalamic loop strength.

Conclusions

ECT-induced seizures show slowing and increased temporal correlations toward termination. These dynamics may be driven by increased cortical E/I ratios and decreased intrathalamic loop strength.

Significance

ECT-induced seizures exhibit characteristic temporal corticothalamic dynamics.

目的：电休克治疗是治疗多种精神疾病的有效方法。皮层和丘脑在癫痫表达和终止中的作用似乎至关重要。本研究采用皮质丘脑平均场模型，基于脑电图特征和生物物理参数研究ect诱发癫痫发作的时空动态。方法：对33例患者345例脑电图进行分析，其中女性19例。脑电特征包括主频率、时间和空间相关性。皮质丘脑生物物理模型评估皮质兴奋/抑制（E/I）平衡和有效的皮质丘脑和丘脑内环路强度。我们跟踪了每个特征和参数从发作到终止的时间演变。结果：随着癫痫发作接近终止，ect诱导的癫痫发作表现为脑电图减慢（即优势频率降低）和时间相关性增加。皮层E/I比值和皮质丘脑回路强度增加，而丘脑内强度降低。脑电图减慢和时间相关性增加都与皮层E/I比值增加和丘脑内环路强度下降有关。结论：ect诱发的癫痫发作表现出缓慢和增加的时间相关性。这些动态可能是由皮质E/I比率增加和丘脑内环路强度下降驱动的。意义：ect诱发的癫痫发作表现出特征性的颞皮质-丘脑动力学。

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引用次数: 0

Optimal parameters for reliable PMv–M1 facilitation identified with dual coil TMS 双线圈TMS鉴定可靠PMv-M1促进的最佳参数

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-11 DOI: 10.1016/j.clinph.2025.2111434

N. Bevacqua , S. Turrini , A. Avenanti

引用次数: 0