Clinical Neurophysiology最新文献

英文中文

Elevated body mass index in youth is associated with neural disinhibition and internetwork functional dysconnectivity: A magnetoencephalography study 青少年身体质量指数升高与神经去抑制和网络间功能连接障碍有关：一项脑磁图研究

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-08 DOI: 10.1016/j.clinph.2025.2111476

A.C. Reichelt , E. Daskalakis , J. Cohen , K.G. Solar , M. Saberi , M. Ventresca , M. Ali , R. Zamyadi , V. Bhat , S.E. Scratch , J. Hamilton , B.T. Dunkley

Objective

The developing brain has a vulnerability to the negative impact of obesity and excessive consumption of hyperpalatable foods. Animal models suggest changes in the excitation:inhibition balance of the brain in obesogenic diets, including disinhibition and hyperexcitability, and altered connectivity between brain regions.

Methods

We investigated the neurophysiological effects of overweight and obesity in 32youth (8–19 years), using a naturalistic viewing protocol with magnetoencephalography (MEG). Subjects were recruited into two groups based on normalised / z-scored body mass index (zBMI), a < 1 SD group (n = 15) and ≥ 1 SD group (n = 17). We assessed spontaneous oscillatory activity and aperiodic components (spectral exponent and offset) and network functional connectivity.

Results

Elevated zBMI was associated with significant increases in gamma activity, as well as a reduced exponent and offset across multiple regions, which suggest changes in neural excitation and inhibition. Additionally, we observed low frequency hypoconnectivity and high frequency hyperconnectivity between multiple brain networks.

Conclusions

These findings underscore the neural impact of body composition on the developing brain, suggesting deleterious alterations in excitation and inhibition and brain networks linked with cognition and behaviour.

Significance

These alterations may contribute to the persistent behavioural rigidity and difficulties in adopting healthier eating behaviours into adulthood.

目的发育中的大脑容易受到肥胖和过度食用美味食物的负面影响。动物模型表明，在致肥性饮食中，大脑的兴奋：抑制平衡发生了变化，包括去抑制和高兴奋性，以及大脑区域之间连接的改变。方法采用自然观察脑磁图（MEG）方法，对32例8 ~ 19岁青少年超重和肥胖的神经生理影响进行研究。根据标准化/ z评分的体重指数（zBMI）将受试者分为两组，1 SD组（n = 15）和≥1 SD组（n = 17）。我们评估了自发振荡活动和非周期成分（谱指数和偏移）以及网络功能连通性。结果zBMI升高与γ活性显著升高相关，且多个区域的指数和偏移量降低，提示神经兴奋和抑制发生变化。此外，我们观察到多个大脑网络之间的低频低连通性和高频超连通性。这些发现强调了身体组成对发育中的大脑的神经影响，表明与认知和行为相关的兴奋和抑制以及大脑网络的有害改变。这些改变可能导致持续的行为僵化和成年后难以采用更健康的饮食行为。

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引用次数: 0

Clinical neurophysiology in movement disorders: toward integration into systems-based practice 运动障碍的临床神经生理学：迈向系统实践的整合。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-16 DOI: 10.1016/j.clinph.2025.2111480

Karlo J. Lizarraga , Robert Chen

引用次数: 0

Brain connectivity predict surgical outcomes of low-grade epilepsy-associated neuroepithelial tumors 脑连通性预测低级别癫痫相关神经上皮肿瘤的手术结果

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-13 DOI: 10.1016/j.clinph.2025.2111478

Wenjie Ming , Yang Zheng , Qi Lian , Chunhong Shen , Yinxi Zhang , Zhongjin Wang , Shuang Wang , Fang Li , Zhe Zheng , Yu Qi , Junming Zhu , Hemmings Wu

Objective

Low-grade epilepsy-associated neuroepithelial tumors (LEATs) often cause drug-resistant epilepsy. Despite complete resection of these lesions, approximately 20% of patients continue to experience suboptimal seizure control. This study aims to investigate the predictive value of quantitative features in determining the surgical outcomes for LEAT patients.

Methods

We retrospectively analyzed 44 temporal LEAT patients who underwent gross-total lesionectomy. EEG features, including power spectral density (PSD) and weighted phase lag index (wPLI), were compared between patients with good (Engel I) and poor (Engel II-IV) outcomes. Significant EEG features were identified through these analyses. Domain Adversarial Neural Network (DANN) was employed to assess the predictive value of these features for surgical outcomes.

Results

No significant PSD differences were found, but patients with good outcomes had higher alpha-band wPLI (p = 0.008). LEATnet, predicted outcomes with an AUC of 0.81and correctly classified 8 of 11 patients in the independent validation cohort.

Conclusions

Alpha-band functional connectivity is a key predictor of surgical outcomes in LEAT patients.

Significance

EEG-based connectivity analysis may improve prognostic accuracy and aid clinical decision-making in LEAT epilepsy.

目的：低级别癫痫相关神经上皮肿瘤（LEATs）常引起耐药癫痫。尽管完全切除了这些病变，大约20%的患者仍然经历不理想的癫痫控制。本研究旨在探讨定量特征在确定LEAT患者手术结果中的预测价值。方法回顾性分析44例颞叶LEAT患者行病灶全切术。比较好（Engel I）和差（Engel II-IV）患者的EEG特征，包括功率谱密度（PSD）和加权相位滞后指数（wPLI）。通过这些分析确定了重要的脑电图特征。应用领域对抗神经网络（DANN）来评估这些特征对手术结果的预测价值。结果两组患者PSD无显著差异，但预后良好的患者α带wPLI较高（p = 0.008）。LEATnet预测结果的AUC为0.81，并在独立验证队列中正确分类了11例患者中的8例。结论alpha -band功能连通性是LEAT患者手术预后的重要预测指标。基于脑电图的连通性分析可提高LEAT癫痫的预后准确性和辅助临床决策。

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引用次数: 0

Spatial activation of motor evoked potentials depends on paired-pulse transcranial magnetic stimulation orientation and intensity 运动诱发电位的空间激活取决于对脉冲经颅磁刺激的方向和强度

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-10 DOI: 10.1016/j.clinph.2025.2111477

Shokoofeh Parvin , Joona Juurakko , Heikki Sinisalo , Giacinto L. Cerone , Alberto Botter , Risto J. Ilmoniemi , Harri Piitulainen , Victor H. Souza

Objective

To investigate how stimulus orientation, intensity, and interstimulus interval (ISI) in paired-pulse transcranial magnetic stimulation (TMS) influence the spatial activation of motor evoked potentials (MEPs) in forearm flexor muscles.

Methods

Paired-pulse paradigms were applied to the motor cortex using multi-coil TMS (mTMS) to control the stimulus parameters electronically without coil repositioning. MEP spatial activation was recorded with a high-density surface electromyography (HDsEMG) grid over the forearm muscles. Conditioning stimuli (CS) were delivered at anterior-to-medial (0°) and posterior-to-medial (90°) orientations and 70–90 % of resting motor threshold (rMT), followed by test stimuli (TS) at 0° and 110 % rMT. ISIs of 0.5 and 8 ms probed neuronal refractoriness and intracortical facilitation, respectively.

Results

MEPs were facilitated at 8-ms and suppressed at 0.5-ms ISI. At 0.5 ms, changing CS orientation from 0° to 90° reduced suppression. Increasing CS intensity shifted activation centroids medially in most cases. Centroids were more medial at 8 ms and more lateral at 0.5 ms.

Conclusions

TMS pulse orientation, intensity, and ISI systematically affect the magnitude and spatial activation of forearm muscles.

Significance

Our findings highlight the utility of mTMS–HDsEMG in probing neurophysiological mechanisms of corticomotor control with important diagnostic and therapeutic clinical implications.

目的探讨双脉冲经颅磁刺激（TMS）对前臂屈肌运动诱发电位（MEPs）空间激活的影响。方法采用多线圈经颅磁刺激（mTMS）对运动皮层进行脉冲电刺激，无需重新定位线圈即可控制刺激参数。通过前臂肌肉的高密度表面肌电图（HDsEMG）网格记录MEP空间激活。条件反射刺激（CS）在前内侧（0°）和后内侧（90°）方向和70 - 90%的静息运动阈值（rMT）上进行，然后是测试刺激（TS）在0°和110% rMT上进行。0.5和8 ms的ISIs分别探测神经元的难治性和皮质内便利化。结果meps在8 ms时促进，在0.5 ms时抑制。在0.5 ms时，将CS方向从0°改变为90°降低了抑制。在大多数情况下，CS强度的增加使激活质心向内移动。结论stms脉冲方向、强度和ISI系统地影响前臂肌肉的大小和空间激活。我们的研究结果强调了mTMS-HDsEMG在探索皮质运动控制的神经生理机制方面的应用，具有重要的诊断和治疗临床意义。

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引用次数: 0

The integrity of double-blinding of continuous theta-burst stimulation targeting the supplementary motor area in a within-subjects design 以辅助运动区域为目标的连续脉冲刺激双盲实验的完整性。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-17 DOI: 10.1016/j.clinph.2025.2111482

Melker Hagsäter , Jonatan Malmros , Jonas Persson , Jonas Jester-Broms , Robert Bodén

引用次数: 0

Is EEG useful in predicting neurotoxicity and outcomes related to chimeric antigen receptor (CAR) T-cell therapy? 脑电图在预测嵌合抗原受体（CAR） t细胞治疗相关的神经毒性和预后方面有用吗？

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-16 DOI: 10.1016/j.clinph.2025.2111484

Brin E. Freund , Adrian Safa , Filippo Emanuele Colella , Guido Chiriboga , Toni Betiku , Andy Shar , Cornelia Drees , Jeffrey Britton , Anteneh M. Feyissa , William O. Tatum

Background

Chimeric antigen receptor (CAR) T-cell therapy revolutionized cancer treatment, though has potential for neurotoxicity (immune effector cell-associated neurotoxicity syndrome, ICANS). EEG has been proposed as a predictive and prognostic tool in ICANS.

Objective

Evaluate pre-treatment EEG, neuroimaging, and clinical features in predicting ICANS, and EEG in prognosis in ICANS.

Methods

Retrospective multicenter study involving adult patients who underwent CAR T-cell therapy at Mayo Clinic Florida, Minnesota, and Arizona between October 2019 and July 2024. Univariable, multivariable and survival analyses were performed.

Results

We included 207 patients (111 female). Pre-treatment EEG was performed in 50.2 % of patients. Multivariable analysis of EEG, imaging, and clinical data demonstrated older age (roughly 1 % increased odds per 1 year of increased age, p = 0.006) and generalized slowing on pre-treatment EEG being associated with ICANS (p = 0.021). There were no factors predictive of hospital duration or survival in ICANS using multivariable analysis. Patients with ICANS had longer hospitalization (p < 0.001) and were less likely to survive at 12- and 24-months (p = 0.001, p < 0.001 respectively).

Conclusion

ICANS is associated with longer hospitalization and worse survival. ICANS risk increases with older age. Generalized slowing on pre-treatment EEG may identify patients at risk of ICANS.

Significance

ICANS is associated with worse outcomes and may be predicted by pre-treatment EEG and older age.

背景：嵌合抗原受体（CAR） t细胞疗法彻底改变了癌症治疗，尽管它有潜在的神经毒性（免疫效应细胞相关神经毒性综合征，ICANS）。脑电图已被建议作为ICANS的预测和预后工具。目的：评价治疗前脑电图、神经影像学和临床特征对ICANS的预测价值，以及脑电图对ICANS预后的影响。方法：回顾性多中心研究，涉及2019年10月至2024年7月期间在佛罗里达州、明尼苏达州和亚利桑那州梅奥诊所接受CAR - t细胞治疗的成年患者。进行单变量、多变量和生存分析。结果：纳入207例患者，其中女性111例。50.2%的患者在治疗前进行脑电图检查。脑电图、影像学和临床数据的多变量分析表明，年龄越大（每增加1年的几率增加约1%，p = 0.006）和治疗前脑电图的普遍减慢与ICANS有关（p = 0.021）。使用多变量分析，没有预测ICANS患者住院时间或生存的因素。结论：ICANS患者住院时间较长，生存期较差。ICANS的风险随着年龄的增长而增加。治疗前脑电图的全身性减慢可以识别有ICANS风险的患者。意义：ICANS与较差的预后相关，可通过治疗前脑电图和年龄预测。

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引用次数: 0

Postoperative epileptiform discharges predict seizure outcomes in pediatric low-grade developmental and epilepsy associated tumors 术后癫痫样放电预测小儿低度发育性和癫痫相关肿瘤的发作结局

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1016/j.clinph.2025.2111462

Florian Mayer , Johannes Zielke , Birgit Pimpel , Katharina Moser , Clara Köller , Sarah Glatter , Gregor Kasprian , Amedeo A. Azizi , Johannes Gojo , Matthias Tomschik , Christian Dorfer , Karl Roessler , Martha Feucht

Objective

To assess the prognostic value of interictal epileptiform discharges (iEDs) on postoperative video-EEG in children and adolescents undergoing epilepsy surgery for low-grade developmental and epilepsy-associated tumors (LEATs).

Methods

This retrospective single-center study analyzed prospectively collected pre- and postoperative EEG data from pediatric LEAT patients. Associations between iED characteristics and seizure outcomes ≥ 24 months after surgery were examined.

Results

Fifty-nine patients with a median postoperative follow-up of 59.0 months (IQR: 36.0–118.0) were included. Univariate analysis identified the presence of a secondary iED focus at 3 months (p = 0.04), persistent iEDs at 12 months (p = 0.007), and a ≥ 50 % increase in iED frequency over time (p = 0.009) as predictors of unfavorable seizure outcomes. Multivariate analysis confirmed that a ≥ 50 % increase in iED frequency within the first 12 months post-surgery was independently associated with unfavorable outcomes (OR: 16.2, 95 % CI: 1.2–555.0, p = 0.037).

Conclusions

Postoperative iEDs, particularly their evolution over time, are valuable predictors of long-term seizure outcomes following LEAT surgery.

Significance

Prognostic models for seizure outcomes in LEAT patients should not only include clinical, radiological and surgical characteristics, but also presence and progression of iEDs in postoperative EEGs.

目的探讨癫痫样放电（ied）对儿童和青少年癫痫手术后低级别发育性和癫痫相关肿瘤（LEATs）的预后价值。方法回顾性单中心研究前瞻性分析小儿LEAT患者术前和术后的脑电图数据。检查iED特征与术后≥24个月癫痫发作结果之间的关系。结果纳入59例患者，术后中位随访59.0个月（IQR: 36.0 ~ 118.0）。单因素分析发现，3个月时继发iED灶（p = 0.04）、12个月时持续iED （p = 0.007）以及iED频率随时间增加≥50% （p = 0.009）是不良癫痫发作结果的预测因素。多因素分析证实，术后前12个月内iED频率增加≥50%与不良结果独立相关（OR: 16.2, 95% CI: 1.2-555.0, p = 0.037）。结论术后ied，特别是其随时间的变化，是LEAT手术后长期癫痫发作结局的重要预测指标。LEAT患者癫痫发作结局的预后模型不仅应包括临床、放射学和外科特征，还应包括术后脑电图中ied的存在和进展。

{"title":"Postoperative epileptiform discharges predict seizure outcomes in pediatric low-grade developmental and epilepsy associated tumors","authors":"Florian Mayer , Johannes Zielke , Birgit Pimpel , Katharina Moser , Clara Köller , Sarah Glatter , Gregor Kasprian , Amedeo A. Azizi , Johannes Gojo , Matthias Tomschik , Christian Dorfer , Karl Roessler , Martha Feucht","doi":"10.1016/j.clinph.2025.2111462","DOIUrl":"10.1016/j.clinph.2025.2111462","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the prognostic value of interictal epileptiform discharges (iEDs) on postoperative video-EEG in children and adolescents undergoing epilepsy surgery for low-grade developmental and epilepsy-associated tumors (LEATs).</div></div><div><h3>Methods</h3><div>This retrospective single-center study analyzed prospectively collected pre- and postoperative EEG data from pediatric LEAT patients. Associations between iED characteristics and seizure outcomes ≥ 24 months after surgery were examined.</div></div><div><h3>Results</h3><div>Fifty-nine patients with a median postoperative follow-up of 59.0 months (IQR: 36.0–118.0) were included. Univariate analysis identified the presence of a secondary iED focus at 3 months (p = 0.04), persistent iEDs at 12 months (p = 0.007), and a ≥ 50 % increase in iED frequency over time (p = 0.009) as predictors of unfavorable seizure outcomes. Multivariate analysis confirmed that a ≥ 50 % increase in iED frequency within the first 12 months post-surgery was independently associated with unfavorable outcomes (OR: 16.2, 95 % CI: 1.2–555.0, p = 0.037).</div></div><div><h3>Conclusions</h3><div>Postoperative iEDs, particularly their evolution over time, are valuable predictors of long-term seizure outcomes following LEAT surgery.</div></div><div><h3>Significance</h3><div>Prognostic models for seizure outcomes in LEAT patients should not only include clinical, radiological and surgical characteristics, but also presence and progression of iEDs in postoperative EEGs.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111462"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145697914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of frequency on dual target deep brain stimulation 频率对双靶深部脑刺激的影响

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI: 10.1016/j.clinph.2025.2111467

Rocio Rodriguez Capilla , Aislinn M. Hurley , Karthik Kumaravelu , Jennifer J. Peters , Hui-Jie Lee , Dennis A. Turner , Warren M. Grill , Stephen L. Schmidt

Background

Deep brain stimulation reduces the motor symptoms of Parkinson’s disease (PD). Dual target deep brain stimulation (DT DBS) may better reduce symptoms and minimize side effects than single target, but the optimal parameters of DT DBS are unknown.

Objective

To quantify the frequency response of DT DBS on bradykinesia and beta oscillations, and to explore intrahemispheric pulse delay shifts as a means to reduce total energy delivered.

Methods

We applied DT DBS using the Summit RC + S in six participants with PD, varying DBS frequency. We further examined the effects of frequency in a biophysical model.

Results

DT DBS at 50 Hz was effective at reducing bradykinesia, whereas increasing DT DBS frequency up to 125 Hz also led to significantly lower beta power. This frequency effect on beta power was replicated in a biophysical model. The model suggested that 22 Hz DT DBS, with an intrahemispheric delay of 40 ms, can reduce beta power by 87 %.

Conclusion

This exploratory study (n = 6) suggests that 125 Hz DT DBS best reduced bradykinesia. However, low frequency DBS with an appropriate intrahemispheric delay could also improve symptom relief.

Significance

Both 125 Hz and tailored low-frequency DT DBS may achieve equivalent symptomatic control of PD symptoms.

脑深部刺激可减轻帕金森病（PD）的运动症状。双靶点深部脑刺激（DT DBS）可能比单靶点更好地减轻症状和减少副作用，但DT DBS的最佳参数尚不清楚。目的量化DT DBS对运动迟缓和β振荡的频率响应，并探讨脑内脉冲延迟移位作为减少总能量传递的手段。方法采用Summit RC + S对6例PD患者进行不同DBS频率的DBS治疗。我们在生物物理模型中进一步研究了频率的影响。结果50 Hz的DBS能有效降低运动迟缓，而125 Hz的DBS频率也能显著降低β功率。这种频率对能量的影响在生物物理模型中得到了复制。该模型表明，22 Hz DT DBS，在半球内延迟40 ms的情况下，可以使β功率降低87%。结论探索性研究（n = 6）表明125 Hz DT DBS治疗运动迟缓效果最好。然而，适当的脑内延迟低频DBS也可以改善症状缓解。意义125 Hz和量身定制的低频DT DBS均可达到PD症状的等效症状控制。

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引用次数: 0

Routine EEG with quantitative analysis to detect delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage 常规脑电图定量分析检测动脉瘤性蛛网膜下腔出血迟发性脑缺血。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-11-20 DOI: 10.1016/j.clinph.2025.2111449

Marina S. Cherchi , Miguel A. Hernández-Hernández , Javier Hernández-Cabello , Eduardo Torres Díez , Pedro Orizaola , Tetyana Stakhurska-Bilynska , Rubén Martín-Láez , José L. Fernández-Torre

Objective

To assess the ability of routine electroencephalography (rEEG) to predict delayed cerebral ischemia (DCI) in aneurysmal subarachnoid hemorrhage (aSAH).

Methods

Single-center prospective study including adult patients with aSAH. Two rEEG recordings with quantitative analysis and transcranial Doppler sonography (TCD) were performed, within the first 72 h (EEG1 and TCD1) and between days 4–7 (EEG2 and TCD2). Multivariate logistic regression was performed to identify DCI predictors.

Results

Seventeen (25.4 %) of 67 patients developed DCI. In qualitative analysis, no patient with a normal EEG1 had DCI, while in EEG2, the absence of bilateral posterior alpha rhythm was more frequently observed in patients with DCI (52.9 % vs 20 %; p = 0.009). Quantitative EEG2 analysis revealed significantly higher total, delta, and theta power in DCI patients, with lower alpha–beta/theta-delta ratio and edge. Delta power ≥ 4.5 μV in EEG2 showed higher sensitivity than vasospasm on TCD2 but lower specificity. Age (OR 1.08; p = 0.04), vasospasm on TCD2 (OR 41.01; p = 0.003) and delta power ≥ 4.5 μV in EEG2 (OR 4.30; p = 0.06) were independent predictors of DCI.

Conclusions

rEEG with quantitative analysis is a useful tool for predicting DCI.

Significance

Integration of rEEG and TCD may improve detection of DCI in aSAH patients.

目的：探讨常规脑电图（rEEG）对动脉瘤性蛛网膜下腔出血（aSAH）迟发性脑缺血（DCI）的预测价值。方法：纳入成年aSAH患者的单中心前瞻性研究。在头72小时（EEG1和TCD1）和第4-7天（EEG2和TCD2）进行2次rEEG定量分析和经颅多普勒超声（TCD）记录。采用多元逻辑回归来确定DCI预测因子。结果：67例患者中17例（25.4%）发生DCI。在定性分析中，EEG1正常的患者没有DCI，而在EEG2中，DCI患者更常观察到双侧后α节律缺失（52.9% vs 20%; p = 0.009）。定量EEG2分析显示，DCI患者的总功率、δ和θ功率显著较高，α - β / δ - δ比值和边缘较低。EEG2 δ功率≥4.5 μV对TCD2的敏感性高于血管痉挛，但特异性较低。年龄（OR 1.08; p = 0.04）、TCD2血管痉挛（OR 41.01; p = 0.003）和EEG2 δ功率≥4.5 μV （OR 4.30; p = 0.06）是DCI的独立预测因子。结论：rEEG结合定量分析是预测DCI的有效工具。意义：结合rEEG和TCD可提高aSAH患者DCI的检出率。

{"title":"Routine EEG with quantitative analysis to detect delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage","authors":"Marina S. Cherchi , Miguel A. Hernández-Hernández , Javier Hernández-Cabello , Eduardo Torres Díez , Pedro Orizaola , Tetyana Stakhurska-Bilynska , Rubén Martín-Láez , José L. Fernández-Torre","doi":"10.1016/j.clinph.2025.2111449","DOIUrl":"10.1016/j.clinph.2025.2111449","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the ability of routine electroencephalography (rEEG) to predict delayed cerebral ischemia (DCI) in aneurysmal subarachnoid hemorrhage (aSAH).</div></div><div><h3>Methods</h3><div>Single-center prospective study including adult patients with aSAH. Two rEEG recordings with quantitative analysis and transcranial Doppler sonography (TCD) were performed, within the first 72 h (EEG1 and TCD1) and between days 4–7 (EEG2 and TCD2). Multivariate logistic regression was performed to identify DCI predictors.</div></div><div><h3>Results</h3><div>Seventeen (25.4 %) of 67 patients developed DCI. In qualitative analysis, no patient with a normal EEG1 had DCI, while in EEG2, the absence of bilateral posterior alpha rhythm was more frequently observed in patients with DCI (52.9 % vs 20 %; p = 0.009). Quantitative EEG2 analysis revealed significantly higher total, delta, and theta power in DCI patients, with lower alpha–beta/theta-delta ratio and edge. Delta power ≥ 4.5 μV in EEG2 showed higher sensitivity than vasospasm on TCD2 but lower specificity. Age (OR 1.08; p = 0.04), vasospasm on TCD2 (OR 41.01; p = 0.003) and delta power ≥ 4.5 μV in EEG2 (OR 4.30; p = 0.06) were independent predictors of DCI.</div></div><div><h3>Conclusions</h3><div>rEEG with quantitative analysis is a useful tool for predicting DCI.</div></div><div><h3>Significance</h3><div>Integration of rEEG and TCD may improve detection of DCI in aSAH patients.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111449"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145602517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trigemino-cervical reflex can be recorded simultaneously with other trigeminal reflexes after V3 stimulation under general anesthesia 全身麻醉V3刺激后三叉-颈反射可与其他三叉反射同时记录。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-01-01 Epub Date: 2025-11-20 DOI: 10.1016/j.clinph.2025.2111448

Denise Lima Medeiros de Melo, Dayanne Rodrigues da Cunha Alves Bento Oliveira, Patricia Lago dos Santos Madureira

引用次数: 0

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