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Mapping direct cortical responses to their underlying cytoarchitectonics 直接映射皮层对其潜在细胞结构的反应
IF 3.6 3区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-04-01 Epub Date: 2026-01-15 DOI: 10.1016/j.clinph.2026.2111505
Aleksander Leon Lysomiski , Jan Van Dijk , Davide Giampiccolo
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引用次数: 0
Excitability prediction of the motor cortex leg representation using EEG-TMS 脑电-经颅磁刺激法预测运动皮层腿部表征的兴奋性。
IF 3.6 3区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-04-01 Epub Date: 2026-02-03 DOI: 10.1016/j.clinph.2026.2111694
Miriam Kirchhoff , Sarah Harders , David Emanuel Vetter , Maria Ermolova , Jiahua Xu , Ulf Ziemann

Objectives

Corticospinal excitability of the motor cortex (M1) hand representation is predicted by phase and power of the sensorimotor mu-rhythm in EEG-TMS studies. Here we address for the first time corticospinal excitability prediction of the M1 leg representation.

Methods

In 16 healthy subjects, 1,000 trials of single-pulse navigated focal TMS to the hot spot of the tibialis anterior muscle were obtained during motor evoked potential (MEP) and EEG recording, using Hjorth montages centered over sensorimotor cortex, ipsilateral to the hemisphere that was targeted by TMS.

Results

Power in the high gamma frequency bands correlated directly, and power in the beta band inversely with MEP amplitude. The phase of the mu-rhythm had no effect but a significant interaction between mu-power and mu-phase was observed: with high mu-power, largest MEPs occurred during the early peak, while with low mu-power largest MEPs were observed during the late peak.

Conclusions

Findings demonstrate that an interaction of mu-power and −phase, and power in other frequency bands of the EEG signal from the sensorimotor cortex prior to the TMS pulse predict corticospinal excitability of the M1 leg representation.

Significance

Findings may inform brain-state dependent stimulation of M1 leg representation for treatment of gait or balance disorders.
目的:通过EEG-TMS研究中感觉-运动mu-节律的相位和功率来预测运动皮层(M1)手表征的皮质脊髓兴奋性。在这里,我们首次讨论了M1腿表征的皮质脊髓兴奋性预测。方法:选取16名健康受试者,在运动诱发电位(MEP)和脑电图(EEG)记录过程中,采用以感觉运动皮层为中心的Hjorth蒙太奇(Hjorth蒙太奇),在经颅磁刺激靶半球同侧,对胫骨前肌热点进行1000次单脉冲导航局灶性经颅磁刺激。结果:高频段功率与MEP幅值成正相关,高频段功率与MEP幅值成负相关。mu节律的相位没有影响,但在mu功率和mu相位之间观察到显著的相互作用:高mu功率时,最大的mep出现在高峰的早期,而低mu功率时,最大的mep出现在高峰的后期。结论:研究结果表明,在TMS脉冲之前,来自感觉运动皮层的脑电图信号的mu-功率和-相位以及其他频段的功率的相互作用预测了M1腿表征的皮质脊髓兴奋性。意义:研究结果可能为M1腿表征脑状态依赖性刺激治疗步态或平衡障碍提供信息。
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引用次数: 0
Influence of stimulus intensity on the TMS induced ipsilateral silent period – Comprehensive findings from a large healthy cohort 刺激强度对经颅磁刺激诱导的同侧沉默期的影响——来自大型健康队列的综合研究结果。
IF 3.6 3区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.clinph.2026.2111588
Matthias Wiemann , Nina Drämel , Mads A.J. Madsen , Hartwig R. Siebner , Martin Lotze , Matthias Grothe , Sebastian Strauss

Introduction

Transcranial magnetic stimulation (TMS) of the primary motor area induces a brief suppression of voluntary muscle activity in electromyography (EMG), known as the ipsilateral silent period (iSP). The iSP reflects transcallosal inhibitory interaction between motor cortices. However, protocols vary, and systematic studies on how stimulation intensity influences the iSP are lacking.

Methods

In 100 healthy young adults, we applied line based neuronavigated single-pulse TMS to both primary motor hand areas at 90–230% of resting motor threshold (RMT). iSPs were recorded at each intensity, and summary statistics were calculated for common parameters. A multilevel mixed-effects model identified variables contributing to differences in outcomes.

Results

We obtained 197 complete datasets (2116 iSPs). iSP duration and depth increased non-linearly with intensity, while onset remained unchanged. Consistently detectable iSPs (>80% occurrence) were observed at 120% RMT. Variability increased at higher intensities, interacting with pre-stimulation EMG.

Conclusion

iSP parameters show a non-linear relationship with intensity, except for onset, with greater variability at higher levels. To minimize variability, we recommend 120–140% RMT.

Significance

This first systematic evaluation of stimulation intensity on iSPs in the largest cohort to date provides recommendations for future TMS studies.
简介:经颅磁刺激(TMS)原发性运动区诱导肌电(EMG)中随意肌活动的短暂抑制,称为同侧沉默期(iSP)。iSP反映了运动皮质间的经胼胝体抑制相互作用。然而,方案各不相同,并且缺乏关于刺激强度如何影响iSP的系统研究。方法:在100名健康年轻人中,我们在90-230%的静息运动阈值(RMT)下对两个主要手部运动区域应用基于线的神经导航单脉冲经颅磁刺激。记录每个强度下的isp,并对常见参数进行汇总统计。多层次混合效应模型确定了导致结果差异的变量。结果:共获得197个完整数据集(2116个isp)。iSP持续时间和深度随强度呈非线性增加,而发作时间不变。在120% RMT时观察到一致可检测到的isp(发生率为80%)。变异性在高强度时增加,与刺激前肌电图相互作用。结论:除发病外,iSP参数与强度呈非线性关系,在较高水平上变异性较大。为了最小化可变性,我们建议RMT为120-140%。意义:这是迄今为止在最大队列中首次对isp刺激强度进行的系统评估,为未来的TMS研究提供了建议。
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引用次数: 0
Abnormal Resting-State EEG delta and alpha rhythms in Huntington’s and Alzheimer’s Diseases: An exploratory study 亨廷顿氏病和阿尔茨海默病静息状态脑电图δ和α节律异常:一项探索性研究
IF 3.6 3区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-04-01 Epub Date: 2026-01-25 DOI: 10.1016/j.clinph.2026.2111518
Dharmendra Jakhar , Giuseppe Noce , Claudio Del Percio , Susanna Lopez , Filippo Carducci , Roberta Lizio , Mina De Bartolo , Verónica Henao Isaza , Asia Macrì , Andrea Soricelli , Marco Salvatore , Giuseppina Ciccarelli , Simona Galluccio , Angelica Di Cecca , Marco Aiello , Bahar Güntekin , Görsev Yener , Federico Massa , Dario Arnaldi , Francesco Famà , Claudio Babiloni

Objectives

This exploratory study tested the hypothesis that Huntington’s disease (HD) is characterized by distinct abnormalities in resting-state electroencephalographic (rsEEG) rhythms compared to Alzheimer’s disease (AD).

Methods

Clinical and rsEEG data were collected from 35 patients with HD, 81 patients with AD, and 102 healthy controls (HC). The rsEEG cortical source activations from 30 electrodes were estimated using eLORETA and were harmonized across clinical sites.

Results

Compared to the HC group, both the HD and AD groups showed widespread increases in rsEEG delta source activation and decreases in alpha source activation, with the HD patients exhibiting the most pronounced frontal effects. In patients with HD, those abnormal rsEEG source activations were associated with cognitive, motor, and functional deficits.

Conclusions

Patients with HD were characterized by a particular slowing of frontal rsEEG rhythms associated with clinically relevant variables.

Significance

A topographically widespread slowing of cortical oscillatory activity was observed in both HD and AD groups, with a particularly pronounced frontal effect in HD, which may predict a greater impact on the sleep–wake cycle. These observations should be considered exploratory and need validation in future studies with enhanced vigilance monitoring during longer rsEEG recordings.
目的:本探索性研究验证了亨廷顿病(HD)与阿尔茨海默病(AD)相比,其特征是静息状态脑电图(rsEEG)节律明显异常的假设。方法收集35例HD患者、81例AD患者和102例健康对照(HC)的临床和rsEEG数据。使用eLORETA估计来自30个电极的rsEEG皮质源激活,并在临床部位进行协调。结果与HC组相比,HD和AD组均表现出广泛的rsEEG δ源激活增加和α源激活减少,其中HD患者表现出最明显的额叶效应。在HD患者中,那些异常的rsEEG源激活与认知、运动和功能缺陷相关。结论HD患者的特点是与临床相关变量相关的额叶reseeg节律减慢。在HD和AD组中都观察到广泛的皮质振荡活动减慢,其中HD的额叶效应特别明显,这可能预示着对睡眠-觉醒周期的更大影响。这些观察结果应该被认为是探索性的,需要在未来的研究中进行验证,在更长的rsEEG记录期间加强警惕性监测。
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引用次数: 0
The dual diversity crisis in TMS-EEG research: population homogeneity and neurobiological heterogeneity as unaddressed validity threats. TMS-EEG研究中的双重多样性危机:群体同质性和神经生物学异质性作为未解决的效度威胁。
IF 3.6 3区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-03-18 DOI: 10.1016/j.clinph.2026.2111852
Thorsten Rudroff
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引用次数: 0
Addressing population and neurobiological diversity in TMS-EEG biomarker research. TMS-EEG生物标志物研究中的人群与神经生物学多样性
IF 3.6 3区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-03-17 DOI: 10.1016/j.clinph.2026.2111851
Ulf Ziemann, Silvia Casarotto, Faranak Farzan, Nigel C Rogasch, Risto J Ilmoniemi
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引用次数: 0
Multiple lesions in traumatic brachial plexopathy: a multimodal image demonstration for preoperative planning. 外伤性臂丛病的多发病变:术前规划的多模态图像论证。
IF 3.6 3区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-03-17 DOI: 10.1016/j.clinph.2026.2111850
Nickolas G Kessler, Robert J Spinner, Nicholas Pulos, Alexander Y Shin, James B Meiling
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引用次数: 0
Predictive value of corticospinal tract integrity and clinical factors for post-stroke motor recovery using diffusion tensor imaging. 弥散张量成像对脑卒中后运动恢复的皮质脊髓束完整性及临床因素的预测价值。
IF 3.6 3区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-03-17 DOI: 10.1016/j.clinph.2026.2111848
Jihee Park, Sekwang Lee, Yoonhye Na, Minjae Cho, Sung-Bom Pyun

Objective: This study aimed to investigate whether initial corticospinal tract (CST) integrity and clinical assessments are associated with motor recovery after stroke and whether follow-up CST evaluation provides additional explanatory value for predicting outcomes.

Methods: Eighty patients with stroke underwent diffusion tensor tractography (DTT) during the subacute and chronic phases. Motor recovery at 6 months was assessed using the Fugl-Meyer Assessment (FMA). Baseline CST integrity was quantified using the fiber-number ratio (FNr). Multivariable regression analyses were conducted to determine the explanatory contributions of baseline and follow-up CST integrity. Among patients with severe motor impairment (initial FMA-upper score <20), motor outcomes were compared between the preserved and disrupted CST groups.

Results: Initial FNr, FMA scores, and muscle strength were independently associated with motor recovery. The inclusion of follow-up CST integrity did not significantly increase the proportion of explained variance in motor outcomes. Among patients with severe impairment, those with preserved CST integrity exhibited significantly higher FMA total scores.

Conclusions: Initial CST integrity and clinical factors were independently associated with motor recovery, whereas follow-up DTT did not provide significant additional explanatory value. Early assessments may inform prognostic evaluation and guide rehabilitation planning, even in patients with severe stroke.

Significance: Early CST integrity is independently associated with motor recovery, supporting its potential as a prognostic biomarker in stroke rehabilitation.

目的:本研究旨在探讨脑卒中后初始皮质脊髓束(CST)完整性和临床评估是否与运动恢复相关,以及随访CST评估是否为预测预后提供了额外的解释价值。方法:80例脑卒中患者分别在亚急性期和慢性期行弥散张量神经束造影(DTT)检查。使用Fugl-Meyer评估(FMA)评估6个月时的运动恢复情况。基线CST完整性采用纤维数比(FNr)进行量化。进行多变量回归分析以确定基线和随访CST完整性的解释贡献。结果:初始FNr、FMA评分和肌力与运动恢复独立相关。纳入随访CST完整性并没有显著增加运动结果中可解释方差的比例。在严重损伤的患者中,保留CST完整性的患者表现出显著更高的FMA总分。结论:初始CST完整性和临床因素与运动恢复独立相关,而随访DTT没有提供显著的额外解释价值。早期评估可以为预后评估提供信息,指导康复计划,甚至对严重中风患者也是如此。意义:早期CST完整性与运动恢复独立相关,支持其作为脑卒中康复预后生物标志物的潜力。
{"title":"Predictive value of corticospinal tract integrity and clinical factors for post-stroke motor recovery using diffusion tensor imaging.","authors":"Jihee Park, Sekwang Lee, Yoonhye Na, Minjae Cho, Sung-Bom Pyun","doi":"10.1016/j.clinph.2026.2111848","DOIUrl":"https://doi.org/10.1016/j.clinph.2026.2111848","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate whether initial corticospinal tract (CST) integrity and clinical assessments are associated with motor recovery after stroke and whether follow-up CST evaluation provides additional explanatory value for predicting outcomes.</p><p><strong>Methods: </strong>Eighty patients with stroke underwent diffusion tensor tractography (DTT) during the subacute and chronic phases. Motor recovery at 6 months was assessed using the Fugl-Meyer Assessment (FMA). Baseline CST integrity was quantified using the fiber-number ratio (FNr). Multivariable regression analyses were conducted to determine the explanatory contributions of baseline and follow-up CST integrity. Among patients with severe motor impairment (initial FMA-upper score <20), motor outcomes were compared between the preserved and disrupted CST groups.</p><p><strong>Results: </strong>Initial FNr, FMA scores, and muscle strength were independently associated with motor recovery. The inclusion of follow-up CST integrity did not significantly increase the proportion of explained variance in motor outcomes. Among patients with severe impairment, those with preserved CST integrity exhibited significantly higher FMA total scores.</p><p><strong>Conclusions: </strong>Initial CST integrity and clinical factors were independently associated with motor recovery, whereas follow-up DTT did not provide significant additional explanatory value. Early assessments may inform prognostic evaluation and guide rehabilitation planning, even in patients with severe stroke.</p><p><strong>Significance: </strong>Early CST integrity is independently associated with motor recovery, supporting its potential as a prognostic biomarker in stroke rehabilitation.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"186 ","pages":"2111848"},"PeriodicalIF":3.6,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of cortico-cortical spectral response analysis parameters for seizure onset zone localization. 癫痫发作区定位的皮质-皮质光谱反应分析参数优化。
IF 3.6 3区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-03-17 DOI: 10.1016/j.clinph.2026.2111855
Helen E Brinyark, Rebekah Chatfield, Caila A Coyne, Ryan West, Brittany H Scheid, Joshua J LaRocque, Arie Nakhmani, Benjamin C Cox, Erin C Conrad, Rachel J Smith

Objective: While cortico-cortical spectral responses (CCSRs) have shown potential for seizure onset zone (SOZ) localization, it is unclear which features of the CCSR are most localizing, limiting their use as potential biomarkers of the SOZ.

Methods: Single-pulse electrical stimulation (SPES) was performed during intracranial EEG (sEEG and ECoG) monitoring in 27 patients, and CCSRs were calculated. We quantified significant increases and decreases in the CCSR and then segmented the CCSRs into 11 time-frequency zones (TFZs). We compared brain regions with the most significant responses in each TFZ to the hypothesized SOZ to determine the localization potential of individual TFZs.

Results: We found that the contacts having the strongest responses in the TFZ spanning the high gamma frequency band (50-250 Hz) and the N2 time interval (50-500 ms) were more related to the SOZ than other TFZs.

Conclusions: These findings suggest that changes in high gamma power 50-500 ms following SPES hold the greatest SOZ localizing potential and may be optimal parameters for investigating the CCSR for biomarkers of the SOZ.

Significance: Optimal interpretation of CCSRs may lead to improved SOZ localization and more favorable treatment outcomes for those with drug-resistant epilepsy.

目的:虽然皮质-皮质光谱反应(CCSR)显示出癫痫发作区(SOZ)定位的潜力,但目前尚不清楚CCSR的哪些特征是最本地化的,这限制了它们作为SOZ潜在生物标志物的使用。方法:对27例患者在颅内脑电图(sEEG和ECoG)监测时进行单脉冲电刺激(SPES),计算ccsr。我们量化了CCSR的显著增加和减少,然后将CCSR划分为11个时频区(TFZs)。我们比较了每个TFZ对假设SOZ反应最显著的大脑区域,以确定单个TFZ的定位潜力。结果:在高γ频带(50 ~ 250 Hz)和N2时间间隔(50 ~ 500 ms)内反应最强的接触点与SOZ的相关性高于其他TFZ。结论:这些发现表明,SPES后50-500 ms的高伽马功率变化具有最大的SOZ定位潜力,可能是研究SOZ生物标志物CCSR的最佳参数。意义:CCSRs的最佳解释可能会改善SOZ定位,并为耐药癫痫患者带来更有利的治疗结果。
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引用次数: 0
Anal sphincter electromyography as a guidance tool for optimal electrode positioning in sacral neuromodulation. 肛门括约肌肌电图作为骶神经调节中最佳电极定位的指导工具。
IF 3.6 3区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-03-17 DOI: 10.1016/j.clinph.2026.2111847
Melita Rotar, Urska Kogovsek
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引用次数: 0
期刊
Clinical Neurophysiology
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