Clinical Neurophysiology最新文献

英文中文

Investigating visuo-tactile mirror properties in borderline personality disorder: A TMS-EEG study 调查边缘型人格障碍的视觉-触觉镜像特性：TMS-EEG 研究。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-11-06 DOI: 10.1016/j.clinph.2024.10.014

Agnese Zazio , Cora Miranda Lanza , Antonietta Stango , Giacomo Guidali , Eleonora Marcantoni , Delia Lucarelli , Serena Meloni , Nadia Bolognini , Roberta Rossi , Marta Bortoletto

Objectives

Patients with borderline personality disorder (pw-BPD) have decreased levels of cognitive empathy, which may be subtended by mirror-like mechanisms in the somatosensory cortices, i.e., the Tactile Mirror System (TaMS). Here, we aimed to shed light on the TaMS and empathic deficits in pw-BPD focusing on connectivity, using transcranial magnetic stimulation and electroencephalography (TMS-EEG).

Methods

After study preregistration, we collected self-report measures of empathic abilities, behavioral performance in a visuo-tactile spatial congruency task investigating TaMS activity, and TMS-evoked potentials (TEPs) from 20 pw-BPD and 20 healthy controls. TMS was delivered over the right primary somatosensory cortex (S1) during touch observation and real touch delivery.

Results

Pw-BPD reported significantly lower levels of cognitive empathy than controls and made significantly more errors in reporting the side of real touches during touch observation. Moreover, pw-BPD presented an altered connectivity pattern from S1-TEPs during touch perception and touch observation, in the last case without differences between human- and object-directed touches.

Conclusions

The results do not support a specific impairment of TaMS in pw-BPD, but reveal significant behavioral and connectivity alterations within the somatosensory network during touch processing.

Significance

The present findings temper the proposed role of the TaMS in BPD, while still highlighting the involvement of somatosensory network alterations.

研究目的边缘型人格障碍（pw-BPD）患者的认知移情能力下降，这可能与体感皮层中的镜像机制（即触觉镜像系统（TaMS））有关。在此，我们旨在利用经颅磁刺激和脑电图（TMS-EEG），以连接性为重点，揭示触觉镜像系统（TaMS）和移情缺陷在 Pw-BPD 中的作用：研究预登记后，我们收集了 20 名 Pw-BPD 和 20 名健康对照者的共情能力自我报告测量结果、视觉-触觉空间一致性任务中调查 TaMS 活动的行为表现以及 TMS 诱发电位 (TEP)。在触觉观察和真实触觉传递过程中，在右侧初级体感皮层（S1）上传递 TMS：结果：与对照组相比，心理障碍患者的认知共情水平明显较低，在触摸观察过程中，他们在报告真实触摸的侧面时出现的错误也明显较多。此外，在触摸感知和触摸观察过程中，pw-BPD 的 S1-TEPs 连接模式发生了改变，在最后一种情况下，人类和物体引导的触摸之间没有差异：结论：本研究结果并不支持 pw-BPD 的 TaMS 存在特定障碍，但揭示了在触觉处理过程中躯体感觉网络内存在显著的行为和连接性改变：重要意义：本研究结果使TaMS在BPD中的作用有所缓和，同时仍强调了躯体感觉网络改变的参与。

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引用次数: 0

Listening for the beat: Low intensity ultrasound modulates heartbeat evoked potentials 聆听心跳低强度超声波调节心跳诱发电位

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-11-01 DOI: 10.1016/j.clinph.2024.09.020

Noah S. Philip, Amanda R. Arulpragasam

引用次数: 0

Low-intensity focused ultrasound to the insula differentially modulates the heartbeat-evoked potential: A proof-of-concept study 低强度聚焦超声波对岛叶的心跳诱发电位有不同程度的调节作用：概念验证研究

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-11-01 DOI: 10.1016/j.clinph.2024.09.006

Andrew Strohman , Gabriel Isaac , Brighton Payne , Charles Verdonk , Sahib S. Khalsa , Wynn Legon

Objective

The heartbeat evoked potential (HEP) is a brain response time-locked to the heartbeat and a potential marker of interoceptive processing that may be generated in the insula and dorsal anterior cingulate cortex (dACC). Low-intensity focused ultrasound (LIFU) can selectively modulate sub-regions of the insula and dACC to better understand their contributions to the HEP.

Methods

Healthy participants (n = 16) received stereotaxically targeted LIFU to the anterior insula (AI), posterior insula (PI), dACC, or Sham at rest during continuous electroencephalography (EEG) and electrocardiography (ECG) recording on separate days. Primary outcome was HEP amplitudes. Relationships between LIFU pressure and HEP changes and effects of LIFU on heart rate and heart rate variability (HRV) were also explored.

Results

Relative to sham, LIFU to the PI, but not AI or dACC, decreased HEP amplitudes; PI effects were partially explained by increased LIFU pressure. LIFU did not affect heart rate or HRV.

Conclusions

These results demonstrate the ability to modulate HEP amplitudes via non-invasive targeting of key interoceptive brain regions.

Significance

Our findings have implications for the causal role of these areas in bottom-up heart-brain communication that could guide future work investigating the HEP as a marker of interoceptive processing in healthy and clinical populations.

目的：心跳诱发电位（HEP心跳诱发电位（HEP）是一种与心跳时间锁定的大脑反应，也是可能在脑岛和背侧前扣带回皮层（dACC）中产生的感知间处理的潜在标记。低强度聚焦超声（LIFU）可选择性地调节岛叶和dACC的子区域，从而更好地了解它们对HEP的贡献。方法：健康参与者（n = 16）在连续脑电图（EEG）和心电图（ECG）记录期间，分别在前岛叶（AI）、后岛叶（PI）、dACC或静息时接受立体定向LIFU。主要结果是HEP振幅。此外，还探讨了 LIFU 压力与 HEP 变化之间的关系，以及 LIFU 对心率和心率变异性（HRV）的影响：结果：与假性相比，LIFU 对 PI（而非 AI 或 dACC）的影响降低了 HEP 波幅；LIFU 压力的增加部分解释了对 PI 的影响。LIFU 不影响心率或心率变异：这些结果表明，通过对关键的感知间脑区进行非侵入性靶向治疗，能够调节 HEP 波幅：我们的研究结果对这些区域在自下而上的心脑交流中的因果作用具有重要意义，可指导未来研究 HEP 作为健康和临床人群感知间处理标记的工作。

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引用次数: 0

Polygenic mutations and their brain spatial expression contribute to presurgical evaluation in patients with refractory focal epilepsy: A case report 多基因突变及其脑空间表达有助于对难治性局灶性癫痫患者进行术前评估：病例报告

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-11-01 DOI: 10.1016/j.clinph.2024.10.015

Yingchun Xu , Ping Jiang , Zixian Zhou , Fangzhou Liu , Yingying Tang , Ling Liu

引用次数: 0

Three montages for Transcranial electric stimulation in predicting the early post-surgery outcome of the facial nerve functioning 经颅电刺激预测面神经功能术后早期疗效的三个蒙太奇。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-11-01 DOI: 10.1016/j.clinph.2024.07.008

Mikael Gian Andrea Izzo , Davide Rossi Sebastiano , Valentina Catanzaro , Ylenia Melillo , Ramona Togni , Elisa Visani , Jacopo Falco , Cecilia Casali , Marco Gemma , Paolo Ferroli , Annamaria Gallone , Daniele Cazzato , Grazia Devigili , Sara Alverà , Paola Lanteri

Objective

We assessed the Transcranial Electrical Stimulation (TES)-induced Corticobulbar-Motor Evoked Potentials (Cb-MEPs) evoked from Orbicularis Oculi (Oc) and Orbicularis Oris (Or) muscles with FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6/-Cz stimulation, during IntraOperative NeuroMonitoring (IONM) in 30 patients who underwent skull-base surgery.

Methods

before (T0) and after (T1) the surgery, we compared the peak-to-peak amplitudes of Cb-MEPs obtained from TES with C3/C4-Cz, C5/C6-Cz and FCC5h/FCC6h-Mz. Then, we compared the response category (present, absent and peripheral) related to different montages. Finally, we classified the Cb-MEPs data from each patient for concordance with clinical outcome and we assessed the diagnostic measures for Cb-MEPs data obtained from FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6-Cz TES stimulation.

Results

Both at T0 and T1, FCC5h/FCC6h-Mz stimulation evoked larger Cb-MEPs than C3/C4-Cz, less peripheral responses from direct activation of facial nerve than C5/C6-Cz. FCC5h/FCC6h-Mz stimulation showed the best accuracy and specificity of Cb-MEPs for clinical outcomes.

Conclusions

FCC5h/FCC6h-Mz stimulation showed the best performances for monitoring the facial nerve functioning, maintaining excellent diagnostic measures even at low stimulus voltages.

Significance

We demonstrated that FCC5h/FCC6h-Mz TES montage for Cb-MEPs in IONM has good accuracy in predicting the post-surgery outcome of facial nerve functioning.

目的我们评估了经颅电刺激（TES）诱发的皮质巴尔运动诱发电位（Cb-MEPs），该诱发电位是在 30 名接受颅底手术的患者接受术中神经监测（IONM）时，用 FCC5h/FCC6h-Mz、C3/C4-Cz 和 C5/C6/-Cz 刺激眼轮匝肌 (Oc) 和眼轮匝肌 (Or) 诱发的。方法：在手术前（T0）和手术后（T1），我们比较了通过 C3/C4-Cz、C5/C6-Cz 和 FCC5h/FCC6h-Mz TES 获得的 Cb-MEP 峰-峰振幅。然后，我们比较了与不同蒙太奇相关的反应类别（存在、不存在和外周）。最后，我们对每位患者的 Cb-MEPs 数据进行了分类，以确定与临床结果的一致性，并评估了从 FCC5h/FCC6h-Mz、C3/C4-Cz 和 C5/C6-Cz TES 刺激中获得的 Cb-MEPs 数据的诊断措施：在 T0 和 T1，FCC5h/FCC6h-Mz 刺激引起的 Cb-MEP 均大于 C3/C4-Cz，直接激活面神经引起的外周反应小于 C5/C6-Cz。FCC5h/FCC6h-Mz刺激对临床结果显示出最佳的Cb-MEPs准确性和特异性：结论：FCC5h/FCC6h-Mz 刺激在监测面神经功能方面表现最佳，即使在低刺激电压下也能保持出色的诊断效果：我们证明了 FCC5h/FCC6h-Mz TES 蒙太奇用于 IONM 中的 Cb-MEPs 在预测手术后面神经功能结果方面具有良好的准确性。

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引用次数: 0

Low-frequency EEG power and coherence differ between drug-induced parkinsonism and Parkinson’s disease 药物诱发的帕金森病与帕金森病的低频脑电图功率和一致性存在差异

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-10-30 DOI: 10.1016/j.clinph.2024.10.013

Seungbeom Seo , Sunmin Kim , Sung-Phil Kim , Jaeho Kim , Suk Yun Kang , Dongil Chung

Objective

Drug-induced parkinsonism (DIP) ranks second to Parkinson’s disease (PD) in causing parkinsonism. Despite sharing similar symptoms, DIP results from exposure to specific medications or substances, underscoring the need for accurate diagnosis. Here, we used resting-state electroencephalography (rsEEG) to investigate neural markers characterizing DIP and PD.

Methods

We conducted a retrospective analysis of rsEEG recordings from 18 DIP patients, 43 de novo PD patients, and 12 healthy controls (HC). After exclusions, data from 15 DIP, 41 PD, and 12 HC participants were analyzed. EEG spectral power and inter-channel coherence were compared across the groups.

Results

Our results demonstrated significant differences in rsEEG patterns among DIP, PD, and HC groups. DIP patients exhibited increased theta band power compared with PD patients and HC. Moreover, DIP patients showed higher delta band coherence compared with PD patients.

Conclusion

The current study highlights the differences in EEG spectral power and inter-channel coherence between DIP and PD patients.

Significance

Our results suggest that rsEEG holds promise as a valuable tool for capturing differential characteristics between DIP and PD patients.

目的药物诱发帕金森病（DIP）是仅次于帕金森病（PD）的第二大帕金森病。尽管症状相似，但药物性帕金森综合征（DIP）是由接触特定药物或物质引起的，因此需要准确诊断。在此，我们使用静息状态脑电图（rsEEG）研究了DIP和PD的神经标记物特征。经过排除，我们分析了 15 名 DIP 患者、41 名 PD 患者和 12 名 HC 患者的数据。结果表明，DIP、PD 和 HC 组之间的 rsEEG 模式存在显著差异。与 PD 患者和 HC 相比，DIP 患者表现出更高的 Theta 波段功率。意义我们的研究结果表明，rsEEG有望成为捕捉DIP和PD患者不同特征的重要工具。

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引用次数: 0

Patterns of ictal surface EEG in occipital seizures: A simultaneous scalp and intracerebral recording study 枕叶癫痫发作时的发作表面脑电图模式：头皮和脑内同步记录研究

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-10-26 DOI: 10.1016/j.clinph.2024.10.012

Margaux Cheval , Mickaël Ferrand , Sophie Colnat-Coubois , Olivier Aron , Louise Tyvaert , Laurent Koessler , Louis Maillard

Objective

To describe the ictal scalp EEG patterns of occipital seizures (OS) and their spatiotemporal correlations with intracerebral occipital ictal discharges derived from simultaneous SEEG-EEG recordings.

Methods

Patients with SEEG confirmed OS (14 OS from 8 patients) were selected from an epilepsy surgery center and were monitored 3–10 days using simultaneous scalp EEG and SEEG recordings.

Results

On scalp EEG, the most common onset patterns were background activity suppression (28.6 %) and high amplitude slow wave corresponding to intracerebral DC-shift (28.6 %) and occurred with a median delay of 0 s after intra-cerebral onset. The initial discharge involved occipital electrodes in only 50 % of the seizures (7/14) with additional basal temporal (8/14) or parietal electrodes (5/14). The onset was ipsilateral to the intra-cerebral onset zone in 71.4 % of seizures and bilateral in the remaining (28.6 %). The most common propagation pattern was either unilateral (50 %) or bilateral (50 %) and a rhythmic slow activity (66.7 %). Different OS subtypes display distinct scalp EEG patterns.

Conclusion

Scalp EEG accurately determines intra-cerebral seizure onset time in OS and has good lateralizing value. However, initial scalp modification does not always involves occipital electrodes and the second modification is well lateralizing in only 50 % of seizures.

Significance

This study describes will help clinicians to better identify OS during video EEG and better plan intra-cerebral explorations for epilepsy surgery.

方法从癫痫外科中心选取经 SEEG 确认的 OS 患者（8 例患者中的 14 例 OS），使用头皮脑电图和 SEEG 同步记录对其进行 3-10 天的监测。结果在头皮脑电图上，最常见的发病模式是背景活动抑制（28.6%）和与脑内直流偏移相对应的高幅慢波（28.6%），脑内发病后的中位延迟时间为 0 秒。只有 50% 的癫痫发作（7/14）的初始放电涉及枕部电极，另有颞叶基底电极（8/14）或顶叶电极（5/14）。在 71.4% 的癫痫发作中，起始点位于大脑内起始区的同侧，其余（28.6%）为双侧。最常见的传播模式是单侧（50%）或双侧（50%）和节律性缓慢活动（66.7%）。结论头皮脑电图能准确判断 OS 的脑内发作起始时间，并具有良好的侧位价值。本研究有助于临床医生在视频脑电图中更好地识别 OS，并更好地规划癫痫手术的脑内探查。

{"title":"Patterns of ictal surface EEG in occipital seizures: A simultaneous scalp and intracerebral recording study","authors":"Margaux Cheval , Mickaël Ferrand , Sophie Colnat-Coubois , Olivier Aron , Louise Tyvaert , Laurent Koessler , Louis Maillard","doi":"10.1016/j.clinph.2024.10.012","DOIUrl":"10.1016/j.clinph.2024.10.012","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the ictal scalp EEG patterns of occipital seizures (OS) and their spatiotemporal correlations with intracerebral occipital ictal discharges derived from simultaneous SEEG-EEG recordings.</div></div><div><h3>Methods</h3><div>Patients with SEEG confirmed OS (14 OS from 8 patients) were selected from an epilepsy surgery center and were monitored 3–10 days using simultaneous scalp EEG and SEEG recordings.</div></div><div><h3>Results</h3><div>On scalp EEG, the most common onset patterns were background activity suppression (28.6 %) and high amplitude slow wave corresponding to intracerebral DC-shift (28.6 %) and occurred with a median delay of 0 s after intra-cerebral onset. The initial discharge involved occipital electrodes in only 50 % of the seizures (7/14) with additional basal temporal (8/14) or parietal electrodes (5/14). The onset was ipsilateral to the intra-cerebral onset zone in 71.4 % of seizures and bilateral in the remaining (28.6 %). The most common propagation pattern was either unilateral (50 %) or bilateral (50 %) and a rhythmic slow activity (66.7 %). Different OS subtypes display distinct scalp EEG patterns.</div></div><div><h3>Conclusion</h3><div>Scalp EEG accurately determines intra-cerebral seizure onset time in OS and has good lateralizing value. However, initial scalp modification does not always involves occipital electrodes and the second modification is well lateralizing in only 50 % of seizures.</div></div><div><h3>Significance</h3><div>This study describes will help clinicians to better identify OS during video EEG and better plan intra-cerebral explorations for epilepsy surgery.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 83-94"},"PeriodicalIF":3.7,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG-based responses of patients with disorders of consciousness and healthy controls to familiar and non-familiar emotional videos 意识障碍患者和健康对照组对熟悉和不熟悉的情感视频的脑电图反应

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-10-26 DOI: 10.1016/j.clinph.2024.10.010

Anny Maza , Sandra Goizueta , María Dolores Navarro , Enrique Noé , Joan Ferri , Valery Naranjo , Roberto Llorens

Objective

To investigate the differences in the brain responses of healthy controls (HC) and patients with disorders of consciousness (DOC) to familiar and non-familiar audiovisual stimuli and their consistency with the clinical progress.

Methods

EEG responses of 19 HC and 19 patients with DOC were recorded while watching emotionally-valenced familiar and non-familiar videos. Differential entropy of the EEG recordings was used to train machine learning models aimed to distinguish brain responses to stimuli type. The consistency of brain responses with the clinical progress of the patients was also evaluated.

Results

Models trained using data from HC outperformed those for patients. However, the performance of the models for patients was not influenced by their clinical condition. The models were successfully trained for over 75% of participants, regardless of their clinical condition. More than 75% of patients whose CRS-R scores increased post-study displayed distinguishable brain responses to both stimuli.

Conclusions

Responses to emotionally-valenced stimuli enabled modelling classifiers that were sensitive to the familiarity of the stimuli, regardless of the clinical condition of the participants and were consistent with their clinical progress in most cases.

Significance

EEG responses are sensitive to familiarity of emotionally-valenced stimuli in HC and patients with DOC.

目的研究健康对照组（HC）和意识障碍患者（DOC）对熟悉和不熟悉视听刺激的大脑反应的差异及其与临床进展的一致性。方法记录19名健康对照组（HC）和19名意识障碍患者在观看情绪化的熟悉和不熟悉视频时的脑电图反应。利用脑电图记录的差分熵来训练机器学习模型，旨在区分大脑对刺激类型的反应。此外，还评估了大脑反应与患者临床进展的一致性。然而，患者模型的表现并不受临床状况的影响。超过 75% 的参与者成功地训练了模型，无论其临床状况如何。超过75%的患者在研究后CRS-R评分上升，他们对这两种刺激都表现出了可区分的大脑反应。结论对情绪化刺激的反应使建模分类器对刺激的熟悉程度敏感，与参与者的临床状况无关，并且在大多数情况下与他们的临床进展一致。

{"title":"EEG-based responses of patients with disorders of consciousness and healthy controls to familiar and non-familiar emotional videos","authors":"Anny Maza , Sandra Goizueta , María Dolores Navarro , Enrique Noé , Joan Ferri , Valery Naranjo , Roberto Llorens","doi":"10.1016/j.clinph.2024.10.010","DOIUrl":"10.1016/j.clinph.2024.10.010","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the differences in the brain responses of healthy controls (HC) and patients with disorders of consciousness (DOC) to familiar and non-familiar audiovisual stimuli and their consistency with the clinical progress.</div></div><div><h3>Methods</h3><div>EEG responses of 19 HC and 19 patients with DOC were recorded while watching emotionally-valenced familiar and non-familiar videos. Differential entropy of the EEG recordings was used to train machine learning models aimed to distinguish brain responses to stimuli type. The consistency of brain responses with the clinical progress of the patients was also evaluated.</div></div><div><h3>Results</h3><div>Models trained using data from HC outperformed those for patients. However, the performance of the models for patients was not influenced by their clinical condition. The models were successfully trained for over 75% of participants, regardless of their clinical condition. More than 75% of patients whose CRS-R scores increased post-study displayed distinguishable brain responses to both stimuli.</div></div><div><h3>Conclusions</h3><div>Responses to emotionally-valenced stimuli enabled modelling classifiers that were sensitive to the familiarity of the stimuli, regardless of the clinical condition of the participants and were consistent with their clinical progress in most cases.</div></div><div><h3>Significance</h3><div>EEG responses are sensitive to familiarity of emotionally-valenced stimuli in HC and patients with DOC.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 104-120"},"PeriodicalIF":3.7,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to "intraoperativecorticobulbar motor evoked potentials and blink reflex during skull base surgery: Significance of anesthetic Regime". 对 "颅底手术中术中皮质束巴运动诱发电位和眨眼反射：麻醉制度的意义"。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-10-25 DOI: 10.1016/j.clinph.2024.10.009

Jiajia Liu, Xing Fan, Lirui Yang, Xiaorong Tao, Yanwen Jin, Ke Li, Jun Yang, Hui Qiao

引用次数: 0

Effects of cervical transcutaneous spinal direct current stimulation on spinal excitability 颈椎经皮脊髓直流电刺激对脊髓兴奋性的影响

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-10-25 DOI: 10.1016/j.clinph.2024.10.011

Luca Pierantoni , Fabrizio Vecchio , Francesca Miraglia , Cristiano Pecchioli , Francesco Iodice , Claudia Carrarini , Mattia Pinardi , Giovanni Di Pino , Silvestro Micera , Paolo Maria Rossini

Objective

To investigate the effects of transcutaneous spinal direct current stimulation (tsDCS) on spinal cord excitability using neurophysiological methods.

Methods

Spinal cord motoneuron excitability was assessed using various neurophysiological techniques in a sham-controlled randomized experiment, which involved delivering 2 mA tsDCS and testing four different montages. Transcranial magnetic stimulation (TMS), F-waves to supramaximal ulnar nerve stimulation and somatosensory evoked potentials to upper limb nerves stimulation were measured in the participants with the electrode configuration that yielded the greatest effect, for a total of about 18 min. 18 young volunteers were recruited.

Results

Among the tested ones, the most promising tsDCS montage was the one with the anode placed on the 7th cervical spinous process and the cathode on the glottis. With this configuration, a significant enhancement of motor responses in the hand muscles to TMS of the contralateral hand motor area was observed during tsDCS (

p < 0.00001

), reaching a plateau after 6 min. This facilitation rapidly declined within a few minutes after the tsDCS was stopped.

Conclusion

Results of the different techniques suggest a possible contribution to facilitatory neuromodulation of the motoneurons at the cervical spine level.

Significance

The occurrence of enhanced excitability after tsDCS suggests potential application in individuals with partial corticospinal fiber impairment affecting hand motor function.

目的通过神经生理学方法研究经皮脊髓直流电刺激（tsDCS）对脊髓兴奋性的影响。方法在一项假对照随机实验中，使用各种神经生理学技术评估脊髓运动神经元的兴奋性，其中包括提供 2 mA tsDCS 和测试四种不同的单体。结果在测试的四种tsDCS组合中，阳极位于第7颈椎棘突、阴极位于声门的组合最有希望。通过这种配置，在tsDCS期间观察到手部肌肉对对侧手部运动区TMS的运动反应明显增强（p<0.00001），6分钟后达到高峰。tsDCS停止后几分钟内，这种促进作用迅速减弱。意义tsDCS后兴奋性增强的现象表明，它有可能应用于影响手部运动功能的部分皮质脊髓纤维损伤患者。

{"title":"Effects of cervical transcutaneous spinal direct current stimulation on spinal excitability","authors":"Luca Pierantoni , Fabrizio Vecchio , Francesca Miraglia , Cristiano Pecchioli , Francesco Iodice , Claudia Carrarini , Mattia Pinardi , Giovanni Di Pino , Silvestro Micera , Paolo Maria Rossini","doi":"10.1016/j.clinph.2024.10.011","DOIUrl":"10.1016/j.clinph.2024.10.011","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of transcutaneous spinal direct current stimulation (tsDCS) on spinal cord excitability using neurophysiological methods.</div></div><div><h3>Methods</h3><div>Spinal cord motoneuron excitability was assessed using various neurophysiological techniques in a sham-controlled randomized experiment, which involved delivering 2 mA tsDCS and testing four different montages. Transcranial magnetic stimulation (TMS), F-waves to supramaximal ulnar nerve stimulation and somatosensory evoked potentials to upper limb nerves stimulation were measured in the participants with the electrode configuration that yielded the greatest effect, for a total of about 18 min. 18 young volunteers were recruited.</div></div><div><h3>Results</h3><div>Among the tested ones, the most promising tsDCS montage was the one with the anode placed on the 7th cervical spinous process and the cathode on the glottis. With this configuration, a significant enhancement of motor responses in the hand muscles to TMS of the contralateral hand motor area was observed during tsDCS (<span><math><mrow><mi>p</mi><mo><</mo><mn>0.00001</mn></mrow></math></span>), reaching a plateau after 6 min. This facilitation rapidly declined within a few minutes after the tsDCS was stopped.</div></div><div><h3>Conclusion</h3><div>Results of the different techniques suggest a possible contribution to facilitatory neuromodulation of the motoneurons at the cervical spine level.</div></div><div><h3>Significance</h3><div>The occurrence of enhanced excitability after tsDCS suggests potential application in individuals with partial corticospinal fiber impairment affecting hand motor function.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 95-103"},"PeriodicalIF":3.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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