Clinical Neurophysiology最新文献

{"title":"Spatiotemporal abnormalities in brain networks as a signature of neurological damage in Wilson’s disease","authors":"Ru-Kai Chen ,&nbsp;Jie Lin ,&nbsp;Chan Zhang ,&nbsp;Wu-Xiang Shi ,&nbsp;Yu-Rong Li ,&nbsp;Zhuo-Peng Hu ,&nbsp;Wan-Jin Chen ,&nbsp;Nai-Qing Cai","doi":"10.1016/j.clinph.2026.2111517","DOIUrl":"10.1016/j.clinph.2026.2111517","url":null,"abstract":"<div><h3>Objectives</h3><div>Resting-state electroencephalogram (EEG) microstates serve as dynamic markers of intrinsic brain activity, reflecting the transient coordination of large-scale neural networks. However, their role in Wilson’s disease (WD) remains largely unexplored. This study aimed to investigate the spatio-temporal dynamics of EEG microstates in WD and explore their relationship with clinical manifestations.</div></div><div><h3>Methods</h3><div>Resting-state EEG data were collected from 17 patients with WD and 17 healthy controls (HCs). Microstate parameters were compared between the two groups. Four commonly recognized typical microstate classes (A-D) were calculated.</div></div><div><h3>Results</h3><div>Microstate analysis results revealed significant differences in the temporal parameters of microstates B, C, and D (<em>p</em> &lt; 0.05) between the HCs and WD patients. Additionally, WD patients exhibited distinct microstate transition patterns (<em>p</em> &lt; 0.05). In the WD cohort, the occurrence and time coverage of microstate B and the transition probability from microstate C to microstate A significantly correlated with the Unified Wilson Disease Rating Scale (UWDRS) scores. The ROC analysis further indicated good discriminative power of these microstate features for differentiating WD patients from HCs.</div></div><div><h3>Conclusions</h3><div>Abnormal microstate dynamics represent a key aspect of neurological impairments in WD, potentially reflecting underlying functional deficits, thereby enhancing our understanding of WD pathophysiology.</div></div><div><h3>Significance</h3><div>This study offers a thorough understanding of the spatiotemporal patterns of brain activity interactions in WD patients.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111517"},"PeriodicalIF":3.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Resting-State EEG delta and alpha rhythms in Huntington’s and Alzheimer’s Diseases: An exploratory study","authors":"Dharmendra Jakhar ,&nbsp;Giuseppe Noce ,&nbsp;Claudio Del Percio ,&nbsp;Susanna Lopez ,&nbsp;Filippo Carducci ,&nbsp;Roberta Lizio ,&nbsp;Mina De Bartolo ,&nbsp;Verónica Henao Isaza ,&nbsp;Asia Macrì ,&nbsp;Andrea Soricelli ,&nbsp;Marco Salvatore ,&nbsp;Giuseppina Ciccarelli ,&nbsp;Simona Galluccio ,&nbsp;Angelica Di Cecca ,&nbsp;Marco Aiello ,&nbsp;Bahar Güntekin ,&nbsp;Görsev Yener ,&nbsp;Federico Massa ,&nbsp;Dario Arnaldi ,&nbsp;Francesco Famà ,&nbsp;Claudio Babiloni","doi":"10.1016/j.clinph.2026.2111518","DOIUrl":"10.1016/j.clinph.2026.2111518","url":null,"abstract":"<div><h3>Objectives</h3><div>This exploratory study tested the hypothesis that Huntington’s disease (HD) is characterized by distinct abnormalities in resting-state electroencephalographic (rsEEG) rhythms compared to Alzheimer’s disease (AD).</div></div><div><h3>Methods</h3><div>Clinical and rsEEG data were collected from 35 patients with HD, 81 patients with AD, and 102 healthy controls (HC). The rsEEG cortical source activations from 30 electrodes were estimated using eLORETA and were harmonized across clinical sites.</div></div><div><h3>Results</h3><div>Compared to the HC group, both the HD and AD groups showed widespread increases in rsEEG delta source activation and decreases in alpha source activation, with the HD patients exhibiting the most pronounced frontal effects. In patients with HD, those abnormal rsEEG source activations were associated with cognitive, motor, and functional deficits.</div></div><div><h3>Conclusions</h3><div>Patients with HD were characterized by a particular slowing of frontal rsEEG rhythms associated with clinically relevant variables.</div></div><div><h3>Significance</h3><div>A topographically widespread slowing of cortical oscillatory activity was observed in both HD and AD groups, with a particularly pronounced frontal effect in HD, which may predict a greater impact on the sleep–wake cycle. These observations should be considered exploratory and need validation in future studies with enhanced vigilance monitoring during longer rsEEG recordings.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111518"},"PeriodicalIF":3.6,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of EEG recording time for juvenile myoclonic epilepsy diagnosis confirmation: a reappraisal","authors":"Guillaume Thévoz ,&nbsp;Davide Bassi ,&nbsp;Andrea O. Rossetti","doi":"10.1016/j.clinph.2026.2111519","DOIUrl":"10.1016/j.clinph.2026.2111519","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111519"},"PeriodicalIF":3.6,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacosamide modulates alpha-band network hubness: a quantitative EEG study in drug-Naïve focal epilepsy","authors":"Marco Sferruzzi ,&nbsp;Lorenzo Ricci ,&nbsp;Margherita A.G. Matarrese ,&nbsp;Mario Tombini ,&nbsp;Patrizia Pulitano ,&nbsp;Francesca Izzi ,&nbsp;Fabio Placidi ,&nbsp;Biagio Sancetta ,&nbsp;Vincenzo Di Lazzaro ,&nbsp;Giovanni Assenza","doi":"10.1016/j.clinph.2026.2111506","DOIUrl":"10.1016/j.clinph.2026.2111506","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates pharmaco-EEG changes induced by Lacosamide (LCM) in drug-naive people with focal epilepsy (PwE) and explores the association between quantitative EEG (qEEG) and long-term clinical outcome.</div></div><div><h3>Methods</h3><div>We retrospectively identified 28 PwE and 25 healthy controls (HC). PwE were classified as seizure-free (SF) or non-seizure-free (NSF) after two years of LCM. EEGs were acquired before and ∼ 6 months after LCM. Power spectral density (PSD), amplitude-envelope correlation (AEC), and graph-theoretical metrics were compared between PwE and HC. Logistic regression was employed to examine the association between long-term outcomes (two-year seizure freedom) and qEEG metrics, in combination with clinical variables (sex, aetiology, seizure type, baseline EEG).</div></div><div><h3>Results</h3><div>LCM did not significantly modify global-averaged qEEG metrics (p &gt; 0.05). Theta-band PSD was higher in PwE than HC. PwE exhibited higher alpha-band betweenness centrality (BtwC) than HC only before LCM (p = 0.007). Alpha-band BtwC provided the greatest discriminative value for seizure freedom (accuracy = 0.86; area under the curve [AUC] = 0.88).</div></div><div><h3>Conclusions</h3><div>Although no significant differences were observed between pre- and post-LCM conditions, alpha-band BtwC showed a return toward a more physiological state after treatment, suggesting partial network normalization. Combining qEEG with clinical data improved long-term outcome discrimination, with alpha-band BtwC as the most relevant feature.</div></div><div><h3>Significance</h3><div>Graph-theoretical qEEG metrics offer additional insight into LCM’s neurophysiological effects in focal epilepsy.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111506"},"PeriodicalIF":3.6,"publicationDate":"2026-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping direct cortical responses to their underlying cytoarchitectonics","authors":"Aleksander Leon Lysomiski ,&nbsp;Jan Van Dijk ,&nbsp;Davide Giampiccolo","doi":"10.1016/j.clinph.2026.2111505","DOIUrl":"10.1016/j.clinph.2026.2111505","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111505"},"PeriodicalIF":3.6,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of ictal OP-MEG","authors":"Stephanie Mellor ,&nbsp;George C. O’Neill ,&nbsp;Daniel Bush ,&nbsp;Arjun Ramaswamy ,&nbsp;Ryan C. Timms ,&nbsp;David Doig ,&nbsp;Tim M. Tierney ,&nbsp;Meaghan E. Spedden ,&nbsp;Matthew C. Walker ,&nbsp;Gareth R. Barnes ,&nbsp;Umesh Vivekananda","doi":"10.1016/j.clinph.2026.2111504","DOIUrl":"10.1016/j.clinph.2026.2111504","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111504"},"PeriodicalIF":3.6,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error processing in major depressive disorder: a systematic review and meta-analysis of event-related potential studies","authors":"Kai-Jie Liang ,&nbsp;Chun-Che Hung ,&nbsp;Chia-Wen Ko ,&nbsp;Pin-Chi Lin ,&nbsp;Pei-Ying S Chan ,&nbsp;Chia-Hsiung Cheng","doi":"10.1016/j.clinph.2026.2111503","DOIUrl":"10.1016/j.clinph.2026.2111503","url":null,"abstract":"<div><h3>Objective</h3><div>Alterations in error-related negativity (ERN) and error positivity (Pe)—electrophysiological markers of error processing—have been frequently reported in major depressive disorder (MDD); findings, however, remain inconsistent.</div></div><div><h3>Methods</h3><div>Literature search was performed using Web of Science, MEDLINE/PubMed, and Scopus electronic databases. The effect sizes (Hedges’ g) in the comparisons of ERN (22 studies) and Pe (10 studies) amplitudes between MDD and healthy controls (HC) were employed by a random-effect, inverse-variance weighted model.</div></div><div><h3>Results</h3><div>ERN and Pe amplitudes in MDD patients were generally comparable to those of HC. Nevertheless, moderator analyses revealed specific conditions under which Pe amplitudes were reduced in MDD. Specifically, MDD patients with comorbid conditions showed diminished Pe amplitudes relative to HC (p = 0.001). Moreover, task type moderated Pe responses: studies using the Flanker task reported significantly reduced Pe amplitudes in MDD patients (p = 0.012), a pattern not observed with other paradigms. No significant moderators were identified for ERN amplitudes.</div></div><div><h3>Conclusions</h3><div>Comorbidity and task design, particularly the use of the Flanker task, appear to influence Pe amplitudes in patients with MDD and should be carefully considered in future research.</div></div><div><h3>Significance</h3><div>Our data highlight the importance of methodological factors in interpreting error processing deficits in MDD.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111503"},"PeriodicalIF":3.6,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.","authors":"Ulf Ziemann, Yang Bai, Fiona M Baumer, Mikkel M Beck, Paolo Belardinelli, Daniele Belvisi, Stephan Bender, Til Ole Bergmann, Marta Bortoletto, Silvia Casarotto, Elias Casula, Arthur R Chaves, Daniel Ciampi de Andrade, Antonella Conte, Zafiris J Daskalakis, Faranak Farzan, Fabio Ferrarelli, Paul B Fitzgerald, Pedro C Gordon, Christian Grefkes, Sylvain Harquel, Julio C Hernandez-Pavon, Aron T Hill, Kate E Hoy, Friedhelm C Hummel, Petro Julkunen, Elisa Kallioniemi, Corey J Keller, Vasilios K Kimiskidis, Melissa Kirkovski, Giacomo Koch, Giorgio Leodori, Pantelis Lioumis, Sara Määttä, Inbal Maidan, Marcello Massimini, Annerose Mengel, Johanna Metsomaa, Carlo Miniussi, Tuomas P Mutanen, Yoshihiro Noda, Recep A Ozdemir, Estelle Raffin, Lorenzo Rocchi, Nigel C Rogasch, Mario Rosanova, Emiliano Santarnecchi, Simone Sarasso, Siobhan M Schabrun, Mouhsin M Shafi, Hartwig R Siebner, Else A Tolner, Leo Tomasevic, Sara Tremblay, Caroline Tscherpel, Domenica Veniero, Viviana Versace, Daphne Voineskos, Steve Vucic, Abraham Zangen, Christoph Zrenner, Risto J Ilmoniemi","doi":"10.1016/j.clinph.2025.2111487","DOIUrl":"https://doi.org/10.1016/j.clinph.2025.2111487","url":null,"abstract":"<p><p>Transcranial magnetic stimulation (TMS) is a non-invasive technique to stimulate the brain, while electroencephalography (EEG) is a non-invasive technique to record its electrical activity. Their combined use (TMS-EEG) has been established only relatively recently, after successful development of TMS-compatible EEG amplifiers. TMS-EEG offers the unparalleled opportunity to directly perturb the brain with TMS and simultaneously record its response with EEG. This allows inferences on causal input-output relationships, therefore going critically beyond purely observational techniques, such as resting-state EEG or functional MRI, in the study of brain dynamics. This consensus review updates the work of Tremblay and coworkers [Clin Neurophysiol 2019; 130: 802-844]. Since then, substantial advances have been made in understanding contamination of TMS-EEG signals by physiological and non-physiological artifacts, as well as in developing strategies to avoid or control them. In parallel, new insights have emerged regarding the physiological mechanisms underlying TMS-EEG responses and their diagnostic and prognostic utility in a broad range of psychiatric and neurological disorders. As such, TMS-EEG is rapidly shaping a dynamic new field in clinical neurophysiology and neuroscience. This review provides a critical and comprehensive synthesis of current knowledge, including practical guidance for implementing TMS-EEG in the clinical setting.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":"2111487"},"PeriodicalIF":3.6,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory and motor cortical hyperexcitability in patients with amyotrophic lateral sclerosis: are they related? a prospective pilot study","authors":"Giovanna Squintani ,&nbsp;Marta Di Muzio ,&nbsp;Andrea Rasera ,&nbsp;Fabio Paio ,&nbsp;Giovanni Umberto Borin ,&nbsp;Kais Humaidan ,&nbsp;Davide Orlando ,&nbsp;Nicola Refatti ,&nbsp;Silvia Romito ,&nbsp;Michele Tinazzi ,&nbsp;Bruno Bonetti ,&nbsp;Mario Ermani","doi":"10.1016/j.clinph.2025.2111485","DOIUrl":"10.1016/j.clinph.2025.2111485","url":null,"abstract":"<div><h3>Objective</h3><div>Our study evaluates sensory and motor cortical hyperexcitability as diagnostic biomarkers in ALS patients and investigates their relationship, identifying distinct or interconnected pathophysiological mechanisms in different sub-groups.</div></div><div><h3>Methods</h3><div>We examined 26 ALS patients and 18 healthy controls. Motor cortex excitability was assessed using transcranial magnetic stimulation to measure the motor evoked potential (MEP) suppression ratio. Somatosensory cortex excitability was evaluated through upper-limb somatosensory evoked potentials (SEPs) with conventional and paired-pulse techniques. Statistical analyses included parametric/non-parametric tests, correlation analyses, and χ² tests. ROC analysis was used to assess diagnostic performance. Significance threshold was p &lt; 0.05.</div></div><div><h3>Results</h3><div>ALS patients showed a significantly reduced MEP suppression ratio (p &lt; 0.001) with excellent discriminative power (100 % accuracy). SEP suppression ratio was significantly lower in ALS (p &lt; 0.001), with sensitivity 76.3 %, specificity 91.7 %, and accuracy 84 %. In patients with giant SEPs, a strong inverse correlation was observed between MEP and SEP suppression ratios (r =  − 0.70, p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>MEP and SEP suppression ratio are robust biomarkers of motor cortical dysfunction in ALS patients with a highlighting cortical heterogeneity between sub-groups, suggesting cortical interconnection.</div></div><div><h3>Significance</h3><div>Alongside confirming motor and sensory cortical hyperexcitability as ALS hallmarks, this study reveals subgroup-specific patterns suggesting a compensatory interplay between sensory and motor cortex.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111485"},"PeriodicalIF":3.6,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced neural speech tracking in adolescents with listening difficulty","authors":"Katsuaki Kojima ,&nbsp;Chunyan Liu ,&nbsp;Shelley Ehrlich ,&nbsp;Harvey Dillon ,&nbsp;Chelsea Blankenship ,&nbsp;Lina Motlagh Zadeh ,&nbsp;Jennifer Vannest ,&nbsp;Lisa Hunter ,&nbsp;Srikantan Nagarajan ,&nbsp;David R. Moore","doi":"10.1016/j.clinph.2026.2111502","DOIUrl":"10.1016/j.clinph.2026.2111502","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate neural mechanisms underlying speech-in-speech listening in adolescents with listening difficulties (LiD).</div></div><div><h3>Methods</h3><div>Neural speech tracking (NST) was assessed using magnetoencephalography (MEG; 275 sensors) in 21 adolescents with LiD (11 females), identified by caregiver report, and 25 typically developing (TD) peers (10 females), all with normal audiograms and frequency-matched on age, sex, race, and ethnicity. Participants completed a cocktail-party task with target speech alone and with competing streams that varied in talker and spatial cues. NST was quantified using theta-band (4–8 Hz) inter-event phase coherence (IEPC) to acoustic edges.</div></div><div><h3>Results</h3><div>Adolescents with LiD showed reduced target-speech NST relative to TD peers, with comparable competitor tracking. Theta-band IEPC correlated with listening ability (partial R² = 0.10; p = 0.037). Concurrent talker and spatial cues synergistically enhanced target-speech NST, especially in TD adolescents, but not competitor streams.</div></div><div><h3>Conclusions</h3><div>LiD is characterized by impaired processing of attended speech rather than enhanced competitor processing or generalized auditory disengagement. Reduced integration of talker and spatial cues in LiD may contribute to real-world listening challenges.</div></div><div><h3>Significance</h3><div>Theta‑band NST provides a clinically relevant neural index of everyday listening and may guide interventions targeting selective attention and cue integration.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111502"},"PeriodicalIF":3.6,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}