Clinical Neurophysiology最新文献_第2页

Reduced alpha-band phase coherence and cortical complexity in fibromyalgia: A tms-eeg exploratory study 纤维肌痛的α带相位一致性和皮质复杂性降低：一项颅磁-脑电图探索性研究。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-05-01 Epub Date: 2026-02-25 DOI: 10.1016/j.clinph.2026.2111711

Anne Jakobsen , Enrico De Martino , Bruno A.N. Couto , Margit M. Bach , Stian Ingemann-Molden , Thorvaldur S. Palsson , Jakob Udby Blicher , Adenauer G. Casali , Thomas Graven-Nielsen , Daniel Ciampi de Andrade

Objectives

Cortico-spinal excitability of the primary motor cortex (M1) is reduced in fibromyalgia, and repetitive transcranial magnetic stimulation (TMS) targeting M1 normalizes these changes and relieves symptoms. TMS combined with electroencephalography (TMS-EEG) allows the measurement of M1 excitability and its connectivity to other regions, which may help clarify neurophysiological abnormalities in fibromyalgia. We assessed cortical excitability, oscillatory activity, and complexity in individuals with fibromyalgia compared to pain-free healthy controls.

Methods

Global- and local-mean field power, peak-to-peak amplitude, event-related spectral perturbation, intertrial coherence (ITC), natural frequency, and perturbational complexity index (PCIst) of the EEG response after left-M1 TMS were compared between groups (n = 18 fibromyalgia; n = 15 controls). Pain intensity, interference, current therapy, mood, and quality of life were assessed in individuals with fibromyalgia.

Results

Compared with controls, individuals with fibromyalgia showed a reduction in the alpha-band ITC in middle- (p = 0.044) and right-parieto-occipital areas (p = 0.040). Middle-parieto-occipital ITC negatively correlated with reported pain relief (rho = -0.552, p = 0.019). The PCIst was lower in fibromyalgia compared with controls (p = 0.009) and correlated with higher pain interference in general activity (rho = -0.486, p = 0.042).

Conclusion

Individuals with fibromyalgia have abnormal cortical connectivity compared with asymptomatic controls.

Significance

TMS-EEG may provide insights on brain connectivity relevant for prognostication and therapy in fibromyalgia.

目的：纤维肌痛患者初级运动皮质（M1）的皮质-脊髓兴奋性降低，针对M1的重复经颅磁刺激（TMS）可使这些变化正常化并缓解症状。经颅磁刺激联合脑电图（TMS- eeg）可以测量M1兴奋性及其与其他区域的连接，这可能有助于阐明纤维肌痛的神经生理异常。我们评估了纤维肌痛患者与无痛健康对照者的皮质兴奋性、振荡活动和复杂性。方法：比较两组（18例纤维肌痛患者和15例对照组）左- m1经颅磁刺激后脑电反应的全局和局部平均场强、峰间振幅、事件相关谱摄动、试验间相干性（ITC）、固有频率和摄动复杂性指数（PCIst）。对纤维肌痛患者的疼痛强度、干扰、当前治疗、情绪和生活质量进行评估。结果：与对照组相比，纤维肌痛患者在中部（p = 0.044）和右侧顶枕区（p = 0.040）的α波段ITC降低。中顶枕ITC与报告的疼痛缓解呈负相关（rho = -0.552, p = 0.019）。与对照组相比，纤维肌痛症患者的PCIst较低（p = 0.009），并且与一般活动中较高的疼痛干扰相关（rho = -0.486, p = 0.042）。结论：与无症状对照相比，纤维肌痛患者的皮质连通性异常。意义：颅磁-脑电图可能为纤维肌痛的预后和治疗提供相关的脑连通性见解。

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引用次数: 0

Experiences of ictal OP-MEG 关键的OP-MEG经验。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-04-01 Epub Date: 2026-01-10 DOI: 10.1016/j.clinph.2026.2111504

Stephanie Mellor , George C. O’Neill , Daniel Bush , Arjun Ramaswamy , Ryan C. Timms , David Doig , Tim M. Tierney , Meaghan E. Spedden , Matthew C. Walker , Gareth R. Barnes , Umesh Vivekananda

引用次数: 0

Lacosamide modulates alpha-band network hubness: a quantitative EEG study in drug-Naïve focal epilepsy 拉科沙胺调节α频带网络中枢：drug-Naïve局灶性癫痫的定量脑电图研究

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-04-01 Epub Date: 2026-01-17 DOI: 10.1016/j.clinph.2026.2111506

Marco Sferruzzi , Lorenzo Ricci , Margherita A.G. Matarrese , Mario Tombini , Patrizia Pulitano , Francesca Izzi , Fabio Placidi , Biagio Sancetta , Vincenzo Di Lazzaro , Giovanni Assenza

Objective

This study investigates pharmaco-EEG changes induced by Lacosamide (LCM) in drug-naive people with focal epilepsy (PwE) and explores the association between quantitative EEG (qEEG) and long-term clinical outcome.

Methods

We retrospectively identified 28 PwE and 25 healthy controls (HC). PwE were classified as seizure-free (SF) or non-seizure-free (NSF) after two years of LCM. EEGs were acquired before and ∼ 6 months after LCM. Power spectral density (PSD), amplitude-envelope correlation (AEC), and graph-theoretical metrics were compared between PwE and HC. Logistic regression was employed to examine the association between long-term outcomes (two-year seizure freedom) and qEEG metrics, in combination with clinical variables (sex, aetiology, seizure type, baseline EEG).

Results

LCM did not significantly modify global-averaged qEEG metrics (p > 0.05). Theta-band PSD was higher in PwE than HC. PwE exhibited higher alpha-band betweenness centrality (BtwC) than HC only before LCM (p = 0.007). Alpha-band BtwC provided the greatest discriminative value for seizure freedom (accuracy = 0.86; area under the curve [AUC] = 0.88).

Conclusions

Although no significant differences were observed between pre- and post-LCM conditions, alpha-band BtwC showed a return toward a more physiological state after treatment, suggesting partial network normalization. Combining qEEG with clinical data improved long-term outcome discrimination, with alpha-band BtwC as the most relevant feature.

Significance

Graph-theoretical qEEG metrics offer additional insight into LCM’s neurophysiological effects in focal epilepsy.

目的研究拉科沙胺（Lacosamide， LCM）致局灶性癫痫（PwE）患者的药物-脑电图变化，并探讨定量脑电图（qEEG）与长期临床预后的关系。方法回顾性分析28例PwE和25例健康对照。LCM治疗2年后，将PwE分为无癫痫发作（SF）和非癫痫发作（NSF）。在LCM前和LCM后6个月采集脑电图。比较了PwE和HC的功率谱密度（PSD）、幅包络相关性（AEC）和图形理论指标。采用Logistic回归，结合临床变量（性别、病因、发作类型、基线EEG），检验长期结局（两年癫痫发作无次数）与qEEG指标之间的关系。结果slcm对全球平均qEEG指标无显著影响（p > 0.05）。PwE组theta波段PSD高于HC组。PwE仅在LCM前表现出高于HC的α带中间度中心性（BtwC）（p = 0.007）。α波段BtwC对癫痫发作自由具有最大的鉴别价值（准确度= 0.86，曲线下面积[AUC] = 0.88）。结论lcm治疗前后BtwC α带虽无明显差异，但治疗后BtwC α带向生理状态恢复，提示网络部分正常化。qEEG与临床资料相结合可改善长期预后判别，其中α波段BtwC是最相关的特征。意义：图理论qEEG指标为LCM在局灶性癫痫中的神经生理作用提供了额外的见解。

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引用次数: 0

Error processing in major depressive disorder: a systematic review and meta-analysis of event-related potential studies 重性抑郁症的错误处理：事件相关电位研究的系统回顾和荟萃分析

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-04-01 Epub Date: 2026-01-09 DOI: 10.1016/j.clinph.2026.2111503

Kai-Jie Liang , Chun-Che Hung , Chia-Wen Ko , Pin-Chi Lin , Pei-Ying S Chan , Chia-Hsiung Cheng

Objective

Alterations in error-related negativity (ERN) and error positivity (Pe)—electrophysiological markers of error processing—have been frequently reported in major depressive disorder (MDD); findings, however, remain inconsistent.

Methods

Literature search was performed using Web of Science, MEDLINE/PubMed, and Scopus electronic databases. The effect sizes (Hedges’ g) in the comparisons of ERN (22 studies) and Pe (10 studies) amplitudes between MDD and healthy controls (HC) were employed by a random-effect, inverse-variance weighted model.

Results

ERN and Pe amplitudes in MDD patients were generally comparable to those of HC. Nevertheless, moderator analyses revealed specific conditions under which Pe amplitudes were reduced in MDD. Specifically, MDD patients with comorbid conditions showed diminished Pe amplitudes relative to HC (p = 0.001). Moreover, task type moderated Pe responses: studies using the Flanker task reported significantly reduced Pe amplitudes in MDD patients (p = 0.012), a pattern not observed with other paradigms. No significant moderators were identified for ERN amplitudes.

Conclusions

Comorbidity and task design, particularly the use of the Flanker task, appear to influence Pe amplitudes in patients with MDD and should be carefully considered in future research.

Significance

Our data highlight the importance of methodological factors in interpreting error processing deficits in MDD.

错误相关负性（ERN）和错误正性（Pe）——错误处理的电生理标记——的改变在重度抑郁症（MDD）中经常被报道；然而，研究结果仍然不一致。方法采用Web of Science、MEDLINE/PubMed、Scopus电子数据库进行文献检索。MDD与健康对照（HC）之间的ERN（22项研究）和Pe（10项研究）振幅比较的效应量（Hedges ' g）采用随机效应、反方差加权模型。结果重度抑郁症患者的sern和Pe波幅与HC大体相当。然而，慢剂分析揭示了MDD中Pe振幅降低的特定条件。具体而言，伴有合并症的重度抑郁症患者的Pe振幅相对于HC降低（p = 0.001）。此外，任务类型调节了Pe反应：使用Flanker任务的研究报告显著降低了重度抑郁症患者的Pe振幅（p = 0.012），这一模式在其他范式中没有观察到。没有发现显著的调节因子对ERN振幅有影响。结论合并症和任务设计，特别是Flanker任务的使用，似乎会影响重度抑郁症患者的Pe振幅，在未来的研究中应仔细考虑。我们的数据强调了方法因素在解释MDD错误处理缺陷中的重要性。

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引用次数: 0

Relevance of EEG recording time for juvenile myoclonic epilepsy diagnosis confirmation: a reappraisal 脑电图记录时间与青少年肌阵挛性癫痫诊断确认的相关性：重新评估。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-04-01 Epub Date: 2026-01-24 DOI: 10.1016/j.clinph.2026.2111519

Guillaume Thévoz , Davide Bassi , Andrea O. Rossetti

引用次数: 0

Memories of Mark. Personal reflections by those in IFCN who worked with Mark Hallett 马克的回忆。IFCN中与Mark Hallett共事的人的个人反思。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-04-01 Epub Date: 2026-02-01 DOI: 10.1016/j.clinph.2026.2111590

David Burke , Robert Chen , Andrew Eisen , Marc Nuwer , Walter Paulus , Paolo Rossini , John Rothwell , Eric Stålberg , Jonathan Cole

引用次数: 0

High-density EEG in the eyes closed condition reveals early reduction of alpha oscillations after galcanezumab: A pilot study in migraine 闭眼状态下的高密度脑电图显示galcanezumab后早期α振荡减少：偏头痛的一项初步研究

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-04-01 Epub Date: 2026-01-30 DOI: 10.1016/j.clinph.2026.2111589

Giulia Furregoni , Letizia Bernardelli , Gabriel Hassan , Marta Porro , Elisabetta Litterio , Marcello Massimini , Michele Colombo , Carlo Lovati , Mario Rosanova

Objective

This study investigates the impact of galcanezumab on spontaneous cortical electrical activity, focusing on its potential to reduce abnormal alpha oscillations.

Methods

We recorded high-density spontaneous EEG (hd-EEG) in 10 migraine patients before (T0) and 7 days after the first galcanezumab administration (T1) in eyes open (EO) and closed (EC) conditions. For each EEG frequency band, we assessed total power, including both aperiodic and periodic components, of the Power Spectral Density (PSD), and compared values between T0 and T1. For the alpha band, we further estimated the change in the periodic component. Clinical changes were assessed through MIDAS and MMD scores after 3 months (T2).

Results

All patients showed clinical improvement. At the electrophysiological level, alpha total power (FDR corrected P = 0.034) and alpha periodic power (P = 0.005) significantly decreased in T1 in EC condition. No significant changes were observed in EO, nor in other frequency bands.

Conclusions

Alpha power, previously found to be elevated in migraine, decreased after galcanezumab treatment in EC condition.

Significance

These findings point to a cortical effect of galcanezumab in migraine patients as early as 7 days after treatment. The EC condition appears particularly sensitive and should be included in future evaluations.

目的本研究探讨galcanezumab对自发皮质电活动的影响，重点关注其减少异常α振荡的潜力。方法对10例偏头痛患者在首次给药前（T0）和第一次给药后（T1）在睁眼（EO）和闭眼（EC）条件下高密度自发脑电图（hd-EEG）进行记录。对于每个EEG频带，我们评估了总功率，包括功率谱密度（PSD）的非周期和周期分量，并比较了T0和T1之间的值。对于alpha波段，我们进一步估计了周期分量的变化。3个月（T2）后通过MIDAS和MMD评分评估临床变化。结果所有患者临床表现均有改善。在电生理水平上，α总功率（FDR校正P = 0.034）和α周期功率（P = 0.005）在T1时显著降低。在EO和其他频段均未观察到明显变化。结论：经galcanezumab治疗后，偏头痛患者的salpha功率降低，而先前发现偏头痛患者的salpha功率升高。这些发现表明，早在治疗后7天，galcanezumab就对偏头痛患者产生皮质效应。欧共体条件似乎特别敏感，应列入今后的评价。

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引用次数: 0

Neurophysiology in the mirror: A tri-layer model of mirror movements informed by TMS evidence 镜子中的神经生理学：经颅磁刺激证据显示的镜子运动的三层模型。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-04-01 Epub Date: 2026-02-03 DOI: 10.1016/j.clinph.2026.2111692

Luca Sebastianelli , Viviana Versace , Davide Ferrazzoli , Paola Ortelli , Eugen Trinka , Johann Sellner , Raffaele Nardone

Objective

Mirror movements are involuntary, task-coupled contractions in contralateral homologous muscles during unilateral movement. While often described as a developmental remnant or rare clinical sign, mirror movements offer insight into the physiological mechanisms that underlie motor lateralization and interhemispheric balance. This review aimed to synthesize the available neurophysiological evidence—primarily from transcranial magnetic stimulation (TMS)—and propose a structured, mechanism-based framework for interpreting mirror movements across neurological conditions.

Methods

A structured narrative review was conducted of studies published between 1966 and November 2025 using TMS in individuals with congenital, developmental, or acquired mirror movements. Studies using neuroimaging or peripheral electrophysiology were included selectively to support anatomical or functional interpretation of TMS findings. Data were organized into three mechanistic layers based on prevailing neurophysiological signatures rather than etiology alone.

Results

Three non-mutually exclusive mechanisms were identified: (I) persistent fast-conducting ipsilateral corticospinal projections, primarily in congenital mirror movement syndromes and early brain injury; (II) deficient transcallosal inhibition, observed in conditions affecting interhemispheric balance such as amyotrophic lateral sclerosis, multiple sclerosis, Parkinson’s disease, and callosal agenesis; and (III) bilateral overactivation of premotor and supplementary motor areas, especially under conditions of impaired motor program selection or increased task demands.

Conclusions

Mirror movements can be interpreted within a tri-layer model reflecting distinct disruptions in corticospinal connectivity, interhemispheric inhibition, and supraspinal motor control.

Significance

This framework provides an integrative model for interpreting neurophysiological findings in mirror movements, offering insight into hierarchical motor control without implying specific diagnostic or therapeutic applications.

目的：镜像运动是单侧运动时对侧同源肌肉的不自主的、任务耦合的收缩。镜像运动通常被描述为一种发育残余或罕见的临床症状，但它提供了对运动侧化和半球间平衡的生理机制的深入了解。本综述旨在综合现有的神经生理学证据——主要来自经颅磁刺激（TMS）——并提出一个结构化的、基于机制的框架来解释神经系统疾病中的镜像运动。方法：对1966年至2025年11月期间发表的使用经颅磁刺激治疗先天性、发育性或获得性镜像运动的研究进行结构化的叙述回顾。选择性地纳入神经影像学或外周电生理学研究，以支持经颅磁刺激结果的解剖或功能解释。数据被组织成三个机制层，基于主要的神经生理特征，而不仅仅是病因学。结果：确定了三种不相互排斥的机制：(1)持续的快速传导同侧皮质脊髓投射，主要发生在先天性镜像运动综合征和早期脑损伤中；（II）经胼胝体抑制缺陷，见于影响半球间平衡的疾病，如肌萎缩侧索硬化、多发性硬化症、帕金森病和胼胝体发育不全；（III）双侧运动前区和辅助运动区过度激活，尤其是在运动项目选择受损或任务要求增加的情况下。结论：镜像运动可以在三层模型中解释，反映了皮质脊髓连通性、半球间抑制和棘上运动控制的明显中断。意义：该框架为解释镜像运动中的神经生理学发现提供了一个综合模型，在不暗示特定诊断或治疗应用的情况下，提供了对分层运动控制的见解。

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引用次数: 0

Peripheral nerve stimulation synchronized with brain stimulation facilitates somatosensory function 周围神经刺激与脑刺激同步，促进体感觉功能。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-04-01 Epub Date: 2026-02-03 DOI: 10.1016/j.clinph.2026.2111693

Yuki Maruyama , Sumiya Shibata , Sho Kojima , Tatsuya Mima , Hideaki Onishi

Objectives

We developed a peripherocentral synchronized stimulation (pcSS) system which enables peripheral nerve stimulation synchronized with transcranial alternating current stimulation (tACS). We investigated the neuromodulatory effects of pcSS to the median nerve and the primary somatosensory cortex (S1) on the somatosensory function and the excitability of the S1 in healthy humans by assessing the two point discrimination (TPD) test and somatosensory evoked potential (SEP).

Methods

Twenty adults participated in this study. tACS was delivered across the right S1. The frequency was individually determined based on the latency of SEP. The left median nerve was stimulated at the specific phases (0 and π) of the tACS.

Results

pcSS with the phase of 0, in which the median nerve stimulation was carried to the S1 at the timing when the peak current flowed in the posterior-anterior direction across the S1, the TPD threshold was decreased and the SEP amplitude was increased. Either pcSS with the phase of π or the median nerve stimulation without tACS did not alter the outcomes.

Conclusion

pcSS induced the different effects depending on the phases of tACS when the peripheral nerve was stimulated.

Significance

pcSS has the potential to become a new intervention for somatosensory rehabilitation.

目的：我们开发了一个外周中枢同步刺激（pcSS）系统，使外周神经刺激与经颅交流电刺激（tACS）同步。通过两点辨别（TPD）测试和体感诱发电位（SEP）测试，研究了pcSS对健康人正中神经和初级体感皮层（S1）的神经调节作用。方法：20名成人参与本研究。tACS通过右侧S1输送。根据SEP潜伏期单独确定频率，在tACS的特定相（0和π）刺激左正中神经。结果：pcSS为0期，在峰值电流经S1后-前方向流过时，将正中神经刺激传递至S1， TPD阈值降低，SEP振幅升高。无论是具有π期的pcSS还是没有tACS的正中神经刺激都没有改变结果。结论：pcSS刺激周围神经时，不同的tACS阶段有不同的效果。意义：pcSS有可能成为躯体感觉康复的一种新的干预手段。

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引用次数: 0

Spatiotemporal abnormalities in brain networks as a signature of neurological damage in Wilson’s disease 脑网络时空异常作为威尔逊病神经损伤的标志。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.clinph.2026.2111517

Ru-Kai Chen , Jie Lin , Chan Zhang , Wu-Xiang Shi , Yu-Rong Li , Zhuo-Peng Hu , Wan-Jin Chen , Nai-Qing Cai

Objectives

Resting-state electroencephalogram (EEG) microstates serve as dynamic markers of intrinsic brain activity, reflecting the transient coordination of large-scale neural networks. However, their role in Wilson’s disease (WD) remains largely unexplored. This study aimed to investigate the spatio-temporal dynamics of EEG microstates in WD and explore their relationship with clinical manifestations.

Methods

Resting-state EEG data were collected from 17 patients with WD and 17 healthy controls (HCs). Microstate parameters were compared between the two groups. Four commonly recognized typical microstate classes (A-D) were calculated.

Results

Microstate analysis results revealed significant differences in the temporal parameters of microstates B, C, and D (p < 0.05) between the HCs and WD patients. Additionally, WD patients exhibited distinct microstate transition patterns (p < 0.05). In the WD cohort, the occurrence and time coverage of microstate B and the transition probability from microstate C to microstate A significantly correlated with the Unified Wilson Disease Rating Scale (UWDRS) scores. The ROC analysis further indicated good discriminative power of these microstate features for differentiating WD patients from HCs.

Conclusions

Abnormal microstate dynamics represent a key aspect of neurological impairments in WD, potentially reflecting underlying functional deficits, thereby enhancing our understanding of WD pathophysiology.

Significance

This study offers a thorough understanding of the spatiotemporal patterns of brain activity interactions in WD patients.

目的：静息状态脑电图（EEG）微状态是脑内在活动的动态标记，反映了大规模神经网络的瞬态协调。然而，它们在威尔逊氏病（WD）中的作用在很大程度上仍未被探索。本研究旨在探讨WD患者脑电微态的时空动态变化及其与临床表现的关系。方法：收集17例WD患者和17例健康对照（hc）静息状态EEG数据。比较两组患者的微状态参数。计算了四种公认的典型微状态类别（A-D）。结果：微状态分析结果显示，微状态B、C和D的时间参数存在显著差异(p)。结论：异常的微状态动力学是WD神经损伤的一个关键方面，可能反映了潜在的功能缺陷，从而增强了我们对WD病理生理学的理解。意义：本研究深入了解了WD患者脑活动相互作用的时空模式。

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引用次数: 0