Pub Date : 2026-01-09DOI: 10.1016/j.clinph.2026.2111503
Kai-Jie Liang , Chun-Che Hung , Chia-Wen Ko , Pin-Chi Lin , Pei-Ying S Chan , Chia-Hsiung Cheng
Objective
Alterations in error-related negativity (ERN) and error positivity (Pe)—electrophysiological markers of error processing—have been frequently reported in major depressive disorder (MDD); findings, however, remain inconsistent.
Methods
Literature search was performed using Web of Science, MEDLINE/PubMed, and Scopus electronic databases. The effect sizes (Hedges’ g) in the comparisons of ERN (22 studies) and Pe (10 studies) amplitudes between MDD and healthy controls (HC) were employed by a random-effect, inverse-variance weighted model.
Results
ERN and Pe amplitudes in MDD patients were generally comparable to those of HC. Nevertheless, moderator analyses revealed specific conditions under which Pe amplitudes were reduced in MDD. Specifically, MDD patients with comorbid conditions showed diminished Pe amplitudes relative to HC (p = 0.001). Moreover, task type moderated Pe responses: studies using the Flanker task reported significantly reduced Pe amplitudes in MDD patients (p = 0.012), a pattern not observed with other paradigms. No significant moderators were identified for ERN amplitudes.
Conclusions
Comorbidity and task design, particularly the use of the Flanker task, appear to influence Pe amplitudes in patients with MDD and should be carefully considered in future research.
Significance
Our data highlight the importance of methodological factors in interpreting error processing deficits in MDD.
错误相关负性（ERN）和错误正性（Pe）——错误处理的电生理标记——的改变在重度抑郁症（MDD）中经常被报道；然而，研究结果仍然不一致。方法采用Web of Science、MEDLINE/PubMed、Scopus电子数据库进行文献检索。MDD与健康对照（HC）之间的ERN（22项研究）和Pe（10项研究）振幅比较的效应量（Hedges ' g）采用随机效应、反方差加权模型。结果重度抑郁症患者的sern和Pe波幅与HC大体相当。然而，慢剂分析揭示了MDD中Pe振幅降低的特定条件。具体而言，伴有合并症的重度抑郁症患者的Pe振幅相对于HC降低（p = 0.001）。此外，任务类型调节了Pe反应：使用Flanker任务的研究报告显著降低了重度抑郁症患者的Pe振幅（p = 0.012），这一模式在其他范式中没有观察到。没有发现显著的调节因子对ERN振幅有影响。结论合并症和任务设计，特别是Flanker任务的使用，似乎会影响重度抑郁症患者的Pe振幅，在未来的研究中应仔细考虑。我们的数据强调了方法因素在解释MDD错误处理缺陷中的重要性。
{"title":"Error processing in major depressive disorder: a systematic review and meta-analysis of event-related potential studies","authors":"Kai-Jie Liang , Chun-Che Hung , Chia-Wen Ko , Pin-Chi Lin , Pei-Ying S Chan , Chia-Hsiung Cheng","doi":"10.1016/j.clinph.2026.2111503","DOIUrl":"10.1016/j.clinph.2026.2111503","url":null,"abstract":"<div><h3>Objective</h3><div>Alterations in error-related negativity (ERN) and error positivity (Pe)—electrophysiological markers of error processing—have been frequently reported in major depressive disorder (MDD); findings, however, remain inconsistent.</div></div><div><h3>Methods</h3><div>Literature search was performed using Web of Science, MEDLINE/PubMed, and Scopus electronic databases. The effect sizes (Hedges’ g) in the comparisons of ERN (22 studies) and Pe (10 studies) amplitudes between MDD and healthy controls (HC) were employed by a random-effect, inverse-variance weighted model.</div></div><div><h3>Results</h3><div>ERN and Pe amplitudes in MDD patients were generally comparable to those of HC. Nevertheless, moderator analyses revealed specific conditions under which Pe amplitudes were reduced in MDD. Specifically, MDD patients with comorbid conditions showed diminished Pe amplitudes relative to HC (p = 0.001). Moreover, task type moderated Pe responses: studies using the Flanker task reported significantly reduced Pe amplitudes in MDD patients (p = 0.012), a pattern not observed with other paradigms. No significant moderators were identified for ERN amplitudes.</div></div><div><h3>Conclusions</h3><div>Comorbidity and task design, particularly the use of the Flanker task, appear to influence Pe amplitudes in patients with MDD and should be carefully considered in future research.</div></div><div><h3>Significance</h3><div>Our data highlight the importance of methodological factors in interpreting error processing deficits in MDD.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111503"},"PeriodicalIF":3.6,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1016/j.clinph.2025.2111485
Giovanna Squintani , Marta Di Muzio , Andrea Rasera , Fabio Paio , Giovanni Umberto Borin , Kais Humaidan , Davide Orlando , Nicola Refatti , Silvia Romito , Michele Tinazzi , Bruno Bonetti , Mario Ermani
Objective
Our study evaluates sensory and motor cortical hyperexcitability as diagnostic biomarkers in ALS patients and investigates their relationship, identifying distinct or interconnected pathophysiological mechanisms in different sub-groups.
Methods
We examined 26 ALS patients and 18 healthy controls. Motor cortex excitability was assessed using transcranial magnetic stimulation to measure the motor evoked potential (MEP) suppression ratio. Somatosensory cortex excitability was evaluated through upper-limb somatosensory evoked potentials (SEPs) with conventional and paired-pulse techniques. Statistical analyses included parametric/non-parametric tests, correlation analyses, and χ2 tests. ROC analysis was used to assess diagnostic performance. Significance threshold was p < 0.05.
Results
ALS patients showed a significantly reduced MEP suppression ratio (p < 0.001) with excellent discriminative power (100 % accuracy). SEP suppression ratio was significantly lower in ALS (p < 0.001), with sensitivity 76.3 %, specificity 91.7 %, and accuracy 84 %. In patients with giant SEPs, a strong inverse correlation was observed between MEP and SEP suppression ratios (r = − 0.70, p < 0.001).
Conclusions
MEP and SEP suppression ratio are robust biomarkers of motor cortical dysfunction in ALS patients with a highlighting cortical heterogeneity between sub-groups, suggesting cortical interconnection.
Significance
Alongside confirming motor and sensory cortical hyperexcitability as ALS hallmarks, this study reveals subgroup-specific patterns suggesting a compensatory interplay between sensory and motor cortex.
{"title":"Sensory and motor cortical hyperexcitability in patients with amyotrophic lateral sclerosis: are they related? a prospective pilot study","authors":"Giovanna Squintani , Marta Di Muzio , Andrea Rasera , Fabio Paio , Giovanni Umberto Borin , Kais Humaidan , Davide Orlando , Nicola Refatti , Silvia Romito , Michele Tinazzi , Bruno Bonetti , Mario Ermani","doi":"10.1016/j.clinph.2025.2111485","DOIUrl":"10.1016/j.clinph.2025.2111485","url":null,"abstract":"<div><h3>Objective</h3><div>Our study evaluates sensory and motor cortical hyperexcitability as diagnostic biomarkers in ALS patients and investigates their relationship, identifying distinct or interconnected pathophysiological mechanisms in different sub-groups.</div></div><div><h3>Methods</h3><div>We examined 26 ALS patients and 18 healthy controls. Motor cortex excitability was assessed using transcranial magnetic stimulation to measure the motor evoked potential (MEP) suppression ratio. Somatosensory cortex excitability was evaluated through upper-limb somatosensory evoked potentials (SEPs) with conventional and paired-pulse techniques. Statistical analyses included parametric/non-parametric tests, correlation analyses, and χ<sup>2</sup> tests. ROC analysis was used to assess diagnostic performance. Significance threshold was p < 0.05.</div></div><div><h3>Results</h3><div>ALS patients showed a significantly reduced MEP suppression ratio (p < 0.001) with excellent discriminative power (100 % accuracy). SEP suppression ratio was significantly lower in ALS (p < 0.001), with sensitivity 76.3 %, specificity 91.7 %, and accuracy 84 %. In patients with giant SEPs, a strong inverse correlation was observed between MEP and SEP suppression ratios (r = − 0.70, p < 0.001).</div></div><div><h3>Conclusions</h3><div>MEP and SEP suppression ratio are robust biomarkers of motor cortical dysfunction in ALS patients with a highlighting cortical heterogeneity between sub-groups, suggesting cortical interconnection.</div></div><div><h3>Significance</h3><div>Alongside confirming motor and sensory cortical hyperexcitability as ALS hallmarks, this study reveals subgroup-specific patterns suggesting a compensatory interplay between sensory and motor cortex.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111485"},"PeriodicalIF":3.6,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1016/j.clinph.2026.2111502
Katsuaki Kojima , Chunyan Liu , Shelley Ehrlich , Harvey Dillon , Chelsea Blankenship , Lina Motlagh Zadeh , Jennifer Vannest , Lisa Hunter , Srikantan Nagarajan , David R. Moore
Objective
To investigate neural mechanisms underlying speech-in-speech listening in adolescents with listening difficulties (LiD).
Methods
Neural speech tracking (NST) was assessed using magnetoencephalography (MEG; 275 sensors) in 21 adolescents with LiD (11 females), identified by caregiver report, and 25 typically developing (TD) peers (10 females), all with normal audiograms and frequency-matched on age, sex, race, and ethnicity. Participants completed a cocktail-party task with target speech alone and with competing streams that varied in talker and spatial cues. NST was quantified using theta-band (4–8 Hz) inter-event phase coherence (IEPC) to acoustic edges.
Results
Adolescents with LiD showed reduced target-speech NST relative to TD peers, with comparable competitor tracking. Theta-band IEPC correlated with listening ability (partial R2 = 0.10; p = 0.037). Concurrent talker and spatial cues synergistically enhanced target-speech NST, especially in TD adolescents, but not competitor streams.
Conclusions
LiD is characterized by impaired processing of attended speech rather than enhanced competitor processing or generalized auditory disengagement. Reduced integration of talker and spatial cues in LiD may contribute to real-world listening challenges.
Significance
Theta‑band NST provides a clinically relevant neural index of everyday listening and may guide interventions targeting selective attention and cue integration.
目的探讨听力障碍青少年语中听的神经机制。方法采用脑磁图（MEG； 275个传感器）对21名青少年（11名女性）和25名正常发育（TD）同龄人（10名女性）的神经语音跟踪（NST）进行评估，这些青少年的听力图正常，年龄、性别、种族和民族的频率匹配。参与者完成了一项鸡尾酒会任务，其中有单独的目标演讲，也有在说话者和空间线索上不同的竞争流。利用theta波段（4-8 Hz）到声学边缘的事件间相位相干性（IEPC）对NST进行量化。结果在竞争对手跟踪方面，低语言障碍青少年的目标言语NST水平低于低语言障碍同龄人。θ波段IEPC与听力能力相关（偏R2 = 0.10; p = 0.037）。同时说话者和空间线索协同增强了目标言语NST，特别是在TD青少年中，但没有竞争者线索。结论滑脱的特点是参与言语加工受损，而非竞争对手加工增强或广义听觉脱离。在LiD中，说话者和空间线索的整合减少可能会导致现实听力挑战。theta - band NST提供了临床相关的日常听力神经指标，可以指导针对选择性注意和线索整合的干预措施。
{"title":"Reduced neural speech tracking in adolescents with listening difficulty","authors":"Katsuaki Kojima , Chunyan Liu , Shelley Ehrlich , Harvey Dillon , Chelsea Blankenship , Lina Motlagh Zadeh , Jennifer Vannest , Lisa Hunter , Srikantan Nagarajan , David R. Moore","doi":"10.1016/j.clinph.2026.2111502","DOIUrl":"10.1016/j.clinph.2026.2111502","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate neural mechanisms underlying speech-in-speech listening in adolescents with listening difficulties (LiD).</div></div><div><h3>Methods</h3><div>Neural speech tracking (NST) was assessed using magnetoencephalography (MEG; 275 sensors) in 21 adolescents with LiD (11 females), identified by caregiver report, and 25 typically developing (TD) peers (10 females), all with normal audiograms and frequency-matched on age, sex, race, and ethnicity. Participants completed a cocktail-party task with target speech alone and with competing streams that varied in talker and spatial cues. NST was quantified using theta-band (4–8 Hz) inter-event phase coherence (IEPC) to acoustic edges.</div></div><div><h3>Results</h3><div>Adolescents with LiD showed reduced target-speech NST relative to TD peers, with comparable competitor tracking. Theta-band IEPC correlated with listening ability (partial R<sup>2</sup> = 0.10; p = 0.037). Concurrent talker and spatial cues synergistically enhanced target-speech NST, especially in TD adolescents, but not competitor streams.</div></div><div><h3>Conclusions</h3><div>LiD is characterized by impaired processing of attended speech rather than enhanced competitor processing or generalized auditory disengagement. Reduced integration of talker and spatial cues in LiD may contribute to real-world listening challenges.</div></div><div><h3>Significance</h3><div>Theta‑band NST provides a clinically relevant neural index of everyday listening and may guide interventions targeting selective attention and cue integration.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111502"},"PeriodicalIF":3.6,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.clinph.2025.2111498
Daniel Boari Coelho , Artur Cesar Aquino dos Santos , Felipe Fregni , Linamara Rizzo Battistella
{"title":"Cortical connectivity reorganization Induced by tDCS and Robotic-Assisted gait training in individuals with spinal cord injury","authors":"Daniel Boari Coelho , Artur Cesar Aquino dos Santos , Felipe Fregni , Linamara Rizzo Battistella","doi":"10.1016/j.clinph.2025.2111498","DOIUrl":"10.1016/j.clinph.2025.2111498","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111498"},"PeriodicalIF":3.6,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.clinph.2025.2111499
Paola Testini , Austin Wang , Eric R. Cole , Svjetlana Miocinovic
Objectives
To determine if motor evoked potentials (MEP) – stimulation-induced muscle activation measured using electromyography – can serve as a biomarker of corticobulbar (CBT) and corticospinal (CST) tract activation induced by deep brain stimulation (DBS).
Methods
In 12 patients with Parkinson’s disease and subthalamic (n = 10) or pallidal (n = 2) DBS, contact mapping determined clinical motor side effect thresholds. For equivalent stimulation parameters (except lower frequency), EMG was recorded from cranial and arm muscles to determine the presence, peak amplitudes and latencies of MEP. Clinical side effect and MEP thresholds were compared and accuracy metrics calculated.
Results
The MEP amplitudes increased with stimulation intensity. Latencies were shorter for cranial muscles, which were also more likely to generate an MEP. Clinical side effect and MEP thresholds were significantly correlated (R2 = 0.31; p = 0.0006), although most MEP thresholds were lower than side effect thresholds. The MEP accuracy in predicting side effects was 0.72, with a sensitivity of 0.68 and a specificity of 0.73.
Conclusions
MEP thresholds correlated with side effect thresholds but were often lower indicating subclinical CBT/CST activations.
Significance
This study characterizes motor potentials evoked by DBS and demonstrates their potential utility as an objective biomarker for motor side effect detection during DBS programming.
{"title":"Motor evoked potentials as a side effect biomarker for deep brain stimulation","authors":"Paola Testini , Austin Wang , Eric R. Cole , Svjetlana Miocinovic","doi":"10.1016/j.clinph.2025.2111499","DOIUrl":"10.1016/j.clinph.2025.2111499","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine if motor evoked potentials (MEP) – stimulation-induced muscle activation measured using electromyography – can serve as a biomarker of corticobulbar (CBT) and corticospinal (CST) tract activation induced by deep brain stimulation (DBS).</div></div><div><h3>Methods</h3><div>In 12 patients with Parkinson’s disease and subthalamic (n = 10) or pallidal (n = 2) DBS, contact mapping determined clinical motor side effect thresholds. For equivalent stimulation parameters (except lower frequency), EMG was recorded from cranial and arm muscles to determine the presence, peak amplitudes and latencies of MEP. Clinical side effect and MEP thresholds were compared and accuracy metrics calculated.</div></div><div><h3>Results</h3><div>The MEP amplitudes increased with stimulation intensity. Latencies were shorter for cranial muscles, which were also more likely to generate an MEP. Clinical side effect and MEP thresholds were significantly correlated (R<sup>2</sup> = 0.31; p = 0.0006), although most MEP thresholds were lower than side effect thresholds. The MEP accuracy in predicting side effects was 0.72, with a sensitivity of 0.68 and a specificity of 0.73.</div></div><div><h3>Conclusions</h3><div>MEP thresholds correlated with side effect thresholds but were often lower indicating subclinical CBT/CST activations.</div></div><div><h3>Significance</h3><div>This study characterizes motor potentials evoked by DBS and demonstrates their potential utility as an objective biomarker for motor side effect detection during DBS programming.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111499"},"PeriodicalIF":3.6,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patients with temporal lobe epilepsy (TLE) suffer from epileptic seizures and memory decline. While focal resection eliminates seizures in 60–70% of patients, surgery carries the risk of further compromising memory. We hypothesized that hippocampal neurofeedback (NF) will induce targeted brain activity associated with memory function.
Methods
Patients with intracranial electrodes implanted in bilateral hippocampi performed a memory NF task, developed specifically for this project. The NF task involved real-time analysis of hippocampal activity using the electrode in the less-affected hippocampus while conducting a memory task. Changes in theta activity and task performance were assessed.
Results
The NF task was conducted in seven TLE patients. In five patients, theta activity increased significantly in the targeted hippocampus (Mann-Kendall test; p < 0.05). Mixed linear model analysis across all sessions revealed a significant increase in theta activity in the targeted hippocampus (p = 0.0032), with no significant change contralaterally (p = 0.19). Three additional TLE patients underwent random NF to assess if theta activity was induced merely by the encoding process, but none of them showed significant changes in theta activity.
Conclusion
Memory NF task effectively induced targeted hippocampal activity in TLE patients.
Significance
Hippocampal NF may enhance memory function in TLE patients prior to focal resection.
{"title":"Optimization of memory neurofeedback system utilizing intracranial electroencephalogram of the hippocampus","authors":"Ako Matsuhashi , Seijiro Shimada , Naoto Kunii , Takeshi Matsuo , Anna Takeda , Toshiya Aono , Shigeta Fujitani , Keisuke Nagata , Makoto Sato , Yohei Ishishita , Kenji Ibayashi , Keisuke Ohtani , Yoshiyuki Onuki , Kensuke Kawai , Nobuhito Saito","doi":"10.1016/j.clinph.2025.2111490","DOIUrl":"10.1016/j.clinph.2025.2111490","url":null,"abstract":"<div><h3>Objective</h3><div>Patients with temporal lobe epilepsy (TLE) suffer from epileptic seizures and memory decline. While focal resection eliminates seizures in 60–70% of patients, surgery carries the risk of further compromising memory. We hypothesized that hippocampal neurofeedback (NF) will induce targeted brain activity associated with memory function.</div></div><div><h3>Methods</h3><div>Patients with intracranial electrodes implanted in bilateral hippocampi performed a memory NF task, developed specifically for this project. The NF task involved real-time analysis of hippocampal activity using the electrode in the less-affected hippocampus while conducting a memory task. Changes in theta activity and task performance were assessed.</div></div><div><h3>Results</h3><div>The NF task was conducted in seven TLE patients. In five patients, theta activity increased significantly in the targeted hippocampus (Mann-Kendall test; p < 0.05). Mixed linear model analysis across all sessions revealed a significant increase in theta activity in the targeted hippocampus (p = 0.0032), with no significant change contralaterally (p = 0.19). Three additional TLE patients underwent random NF to assess if theta activity was induced merely by the encoding process, but none of them showed significant changes in theta activity.</div></div><div><h3>Conclusion</h3><div>Memory NF task effectively induced targeted hippocampal activity in TLE patients.</div></div><div><h3>Significance</h3><div>Hippocampal NF may enhance memory function in TLE patients prior to focal resection.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111490"},"PeriodicalIF":3.6,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-22DOI: 10.1016/j.clinph.2025.2111489
William O. Tatum , Adrian Safa , Filippo Colella , Erik H. Middlebrooks , Anteneh M. Feyissa , Aafreen Khan , David Sabsevitz , Alicia Kissinger-Knox , Phillip Gauthier , Dawn Radford , Anahita Jafari , Marco Failla Mulone , Sanjeet Grewal , Rich Byrne , Kaisorn Chaichana , Alfredo Quinones-Hinojosa , Brin Freund
Objective
To compare the signal detection performance of a circular grid versus a strip electrode during intraoperative electrocorticography (iECoG) for Functional Brain Mapping (FBM).
Methods
We performed a single center retrospective evaluation of signal detection by recording intraoperative ECoG comparing two intraoperative recording devices and techniques during awake craniotomy for FBM. A circular grid and linear strip evaluated stimulation artifact, afterdischarges (ADs), and epileptiform activity.
Results
142 patients underwent awake craniotomy, and 26 (18.3 %) had reoperations with repeat iECoG performed during their subsequent procedure. A total of 71 patients underwent iECoG using circular grids and 71 with linear strip electrodes. Max and min Signal amplitudes were higher with the circular grid (p < 0.01). The minimum (2.3 vs. 2.8 mA) and maximum (4.9 vs. 6.3 mA) currents required to evoke visible stimulation artifact were lower with the circular grid (p < 0.01), suggesting increased sensitivity to stimulation-related signals. Physiological signals represented by ADs were detected in 59.2 % of circular-grid patients vs 40.8 % of strip-electrode patients (Fisher’s exact p = 0.044). When adjusting for stimulation trials in a Negative Binomial model with an offset, AD rates per stimulation were 2.5 × higher with circular grids (rate ratio 2.51; 95 % CI 1.61–3.91; p < 0.0001). Total stimulation counts were 2,786 (circular) and 2,209 (strip). Notably, the circular grid also involved more electrodes (5.06 vs. 0.95, p < 0.001).
Conclusions
High-density circular grids enhance intraoperative detection of artifacts and ADs with lower stimulus currents.
Significance
The high-density circular grid offered more interpretable contacts and higher sensitivity.
{"title":"Artifactual signal detection using intraoperative electrocorticographic devices during functional brain mapping of brain tumors","authors":"William O. Tatum , Adrian Safa , Filippo Colella , Erik H. Middlebrooks , Anteneh M. Feyissa , Aafreen Khan , David Sabsevitz , Alicia Kissinger-Knox , Phillip Gauthier , Dawn Radford , Anahita Jafari , Marco Failla Mulone , Sanjeet Grewal , Rich Byrne , Kaisorn Chaichana , Alfredo Quinones-Hinojosa , Brin Freund","doi":"10.1016/j.clinph.2025.2111489","DOIUrl":"10.1016/j.clinph.2025.2111489","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the signal detection performance of a circular grid versus a strip electrode during intraoperative electrocorticography (iECoG) for Functional Brain Mapping (FBM).</div></div><div><h3>Methods</h3><div>We performed a single center retrospective evaluation of signal detection by recording intraoperative ECoG comparing two intraoperative recording devices and techniques during awake craniotomy for FBM. A circular grid and linear strip evaluated stimulation artifact, afterdischarges (ADs), and epileptiform activity.</div></div><div><h3>Results</h3><div>142 patients underwent awake craniotomy, and 26 (18.3 %) had reoperations with repeat iECoG performed during their subsequent procedure. A total of 71 patients underwent iECoG using circular grids and 71 with linear strip electrodes. Max and min Signal amplitudes were higher with the circular grid (p < 0.01). The minimum (2.3 vs. 2.8 mA) and maximum (4.9 vs. 6.3 mA) currents required to evoke visible stimulation artifact were lower with the circular grid (p < 0.01), suggesting increased sensitivity to stimulation-related signals. Physiological signals represented by ADs were detected in 59.2 % of circular-grid patients vs 40.8 % of strip-electrode patients (Fisher’s exact p = 0.044). When adjusting for stimulation trials in a Negative Binomial model with an offset, AD rates per stimulation were 2.5 × higher with circular grids (rate ratio 2.51; 95 % CI 1.61–3.91; p < 0.0001). Total stimulation counts were 2,786 (circular) and 2,209 (strip). Notably, the circular grid also involved more electrodes (5.06 vs. 0.95,<!--> <!-->p < 0.001).</div></div><div><h3>Conclusions</h3><div>High-density circular grids enhance intraoperative detection of artifacts and ADs with lower stimulus currents.</div></div><div><h3>Significance</h3><div>The high-density circular grid offered more interpretable contacts and higher sensitivity.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111489"},"PeriodicalIF":3.6,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145832922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-20DOI: 10.1016/j.clinph.2025.2111488
Clotilde Turpin, Olivier Rossel, Félix Schlosser-Perrin, Riki Matsumoto, Emmanuel Mandonnet, Sam Ng, Hugues Duffau, François Bonnetblanc
Objectives: Cyto-myelo architecture vary across brain regions, particularly between primary areas (motor M1, sensory S1), the premotor cortex and the more associative areas such as the Broca, Wernicke, and other association areas. Due to the specific characteristics of electrical stimulation, these architectural variations should be reflected in cortical responses evoked by direct electrical stimulation (DES). We sought to test this hypothesis.
Methods: DES was administered directly to different regions of the cortex while recording DCRs (direct cortical responses) in 10 patients. The shapes of the first components P0 and N1 of the signals were analyzed.
Results: The downward slope of the first component (P0) of the signal is statistically greater for responses recorded in precentral motor cortex and S1 than that of EPs recorded in more associative areas.
Conclusions: Precentral motor cortex and S1 are distinguished by the presence of larger diameter, heavily myelinated fibers. These anatomical features explain the response and the increased slope of the P0 component in these regions, compared to associative areas.
Significance: The first component of DES-evoked responses reflects myelo architecture in particular. This could form the basis of an electrodiagnostic method using the evoked response.
{"title":"Influence of myelo-architectures on direct cortical response evoked by electrical stimulation.","authors":"Clotilde Turpin, Olivier Rossel, Félix Schlosser-Perrin, Riki Matsumoto, Emmanuel Mandonnet, Sam Ng, Hugues Duffau, François Bonnetblanc","doi":"10.1016/j.clinph.2025.2111488","DOIUrl":"https://doi.org/10.1016/j.clinph.2025.2111488","url":null,"abstract":"<p><strong>Objectives: </strong>Cyto-myelo architecture vary across brain regions, particularly between primary areas (motor M1, sensory S1), the premotor cortex and the more associative areas such as the Broca, Wernicke, and other association areas. Due to the specific characteristics of electrical stimulation, these architectural variations should be reflected in cortical responses evoked by direct electrical stimulation (DES). We sought to test this hypothesis.</p><p><strong>Methods: </strong>DES was administered directly to different regions of the cortex while recording DCRs (direct cortical responses) in 10 patients. The shapes of the first components P0 and N1 of the signals were analyzed.</p><p><strong>Results: </strong>The downward slope of the first component (P0) of the signal is statistically greater for responses recorded in precentral motor cortex and S1 than that of EPs recorded in more associative areas.</p><p><strong>Conclusions: </strong>Precentral motor cortex and S1 are distinguished by the presence of larger diameter, heavily myelinated fibers. These anatomical features explain the response and the increased slope of the P0 component in these regions, compared to associative areas.</p><p><strong>Significance: </strong>The first component of DES-evoked responses reflects myelo architecture in particular. This could form the basis of an electrodiagnostic method using the evoked response.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":"2111488"},"PeriodicalIF":3.6,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145832834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cortical tremor (CT), a rhythmic variant of cortical myoclonus (CM), is the hallmark of benign adult familial myoclonus epilepsy (BAFME), though the underlying mechanism of rhythmicity remains unproven. This study aimed to reveal the cortical rhythmic activity of CT using induced activity analysis for somatosensory evoked potentials (SEP).
Methods
We investigated 46 SEP datasets from 23 patients (11 with BAFME, 12 with other CM) and 35 SEPs from 18 healthy controls. SEPs were recorded by 1.1-Hz stimuli at a sampling rate of 10,000 Hz. A short-time Fourier transform was applied to each SEP epoch, and the power spectrums were averaged. We set an analysis window of 0–150 ms and a frequency range of 0–1,000 Hz for time–frequency representation and compared the induced power changes between groups.
Results
Stimulus-induced power changes over a wide-band (0–1000 Hz) were conspicuously prominent in BAFME patients compared to both CM and controls. These activities presented repetitive and alternating increases and decreases in power and its total number of induced activities were the highest in age 40s and declined with aging.
Conclusions
We demonstrated rhythmic cortical activity in BAFME patients, which may reflect the underlying pathophysiology of CT.
Significance
Detecting the induced activity of a single somatosensory stimulus may offer novel insights into the pathophysiology of BAFME.
{"title":"Repetitive wide-band cortical power in benign adult familial myoclonus epilepsy","authors":"Haruo Yamanaka , Katsuya Kobayashi , Takefumi Hitomi , Maya Tojima , Masao Matsuhashi , Kiyohide Usami , Ryosuke Takahashi , Akio Ikeda","doi":"10.1016/j.clinph.2025.2111486","DOIUrl":"10.1016/j.clinph.2025.2111486","url":null,"abstract":"<div><h3>Background</h3><div>Cortical tremor (CT), a rhythmic variant of cortical myoclonus (CM), is the hallmark of benign adult familial myoclonus epilepsy (BAFME), though the underlying mechanism of rhythmicity remains unproven. This study aimed to reveal the cortical rhythmic activity of CT using induced activity analysis for somatosensory evoked potentials (SEP).</div></div><div><h3>Methods</h3><div>We investigated 46 SEP datasets from 23 patients (11 with BAFME, 12 with other CM) and 35 SEPs from 18 healthy controls. SEPs were recorded by 1.1-Hz stimuli at a sampling rate of 10,000 Hz. A short-time Fourier transform was applied to each SEP epoch, and the power spectrums were averaged. We set an analysis window of 0–150 ms and a frequency range of 0–1,000 Hz for time–frequency representation and compared the induced power changes between groups.</div></div><div><h3>Results</h3><div>Stimulus-induced power changes over a wide-band (0–1000 Hz) were conspicuously prominent in BAFME patients compared to both CM and controls. These activities presented repetitive and alternating increases and decreases in power and its total number of induced activities were the highest in age 40s and declined with aging.</div></div><div><h3>Conclusions</h3><div>We demonstrated rhythmic cortical activity in BAFME patients, which may reflect the underlying pathophysiology of CT.</div></div><div><h3>Significance</h3><div>Detecting the induced activity of a single somatosensory stimulus may offer novel insights into the pathophysiology of BAFME.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111486"},"PeriodicalIF":3.6,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.clinph.2025.2111483
Marco Antonio Cavalcanti Garcia , Anaelli Aparecida Nogueira-Campos
{"title":"Revisiting the accuracy of motor evoked potential determination: The overlooked role of surface electrode montage","authors":"Marco Antonio Cavalcanti Garcia , Anaelli Aparecida Nogueira-Campos","doi":"10.1016/j.clinph.2025.2111483","DOIUrl":"10.1016/j.clinph.2025.2111483","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111483"},"PeriodicalIF":3.6,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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