Clinical Neurophysiology最新文献

英文中文

Ultrasonographic characteristics of peripheral neuropathy in systemic lupus erythematosus 系统性红斑狼疮周围神经病变的超声特征。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.002

Nan Hu , Yuxue Nie , Xingbei Dong , Jingwen Niu , Liying Cui , Mingsheng Liu

Objective

To explore the ultrasonographic characteristics of SLE-related peripheral neuropathy (PN) using nerve ultrasound.

Methods

Patients with SLE were recruited consecutively between December 2022 and June 2023. Detailed clinical assessment and nerve ultrasound were conducted on each SLE patient and healthy control (HC) at predetermined sites of peripheral nerves. The upper limit of the CSA for each nerve location was defined as 95th percentile in healthy controls for the identification of nerve enlargement. Nerve conduction studies (NCS) and relevant ancillary examinations were conducted on all SLE patients for comparisons.

Results

A total of 32 SLE female patients and age- and gender-marched 52 HC were finally recruited. At M6 (P = 0.041) point of median nerve, U1 (P < 0.001) and U6-10 (P < 0.001, =0.008, <0.001, <0.001, <0.001, respectively) points of ulnar nerve, the CSA in SLE patients were remarkably higher than that in HC. Mild and moderate nerve enlargement were detected in 12 and 20 SLE patients, respectively. Only 12 tested nerves showed both axonal damage in electrophysiological studies and nerve enlargement under ultrasound.

Conclusion

Nerve enlargement was extremely common in SLE patients, mainly in the forms of mild to moderate and focal thickening in upper limbs. There was significant inconsistency between NCS and ultrasound in detecting peripheral nerve involvement and a combined examination using NCS and nerve ultrasound might be more effective in detecting SLE-related PN.

目的：利用神经超声探讨sle相关性周围神经病变（PN）的声像图特征。方法：在2022年12月至2023年6月期间连续招募SLE患者。在预定的周围神经位置对每位SLE患者和健康对照（HC）进行详细的临床评估和神经超声检查。每个神经位置的CSA上限被定义为健康对照的第95个百分位数，以识别神经扩张。对所有SLE患者进行神经传导研究（NCS）及相关辅助检查进行比较。结果：最终共招募了32例SLE女性患者和52例不同年龄和性别的HC患者。结论：神经扩张在SLE患者中极为常见，主要表现为上肢轻度至中度及局灶性增厚。NCS与超声在检测周围神经受累方面存在明显的不一致性，NCS与神经超声联合检查可能更有效地检测sle相关PN。

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引用次数: 0

High-density theta oscillatory-modulated tDCS over the parietal cortex for targeted memory enhancement 通过顶叶皮层的高密度θ振荡调制tDCS，有针对性地增强记忆。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.004

Milica Manojlović , Jovana Bjekić , Danka Purić , Saša R. Filipović

Objectives

Associative memory (AM) declines due to healthy aging as well as in various neurological conditions. Standard transcranial electrical stimulation (tES) protocols show inconclusive facilitatory effects on AM, often lacking function specificity and stimulation focality. We tested the effectiveness of high-density electrode montage delivering anodal theta oscillatory-modulated transcranial direct current stimulation (HD-Theta-otDCS) over the left posterior parietal cortex (PPC), aiming to target AM in a spatially focused and function-specific manner.

Methods

In a sham-controlled cross-over experiment we explored the differential effects of HD-Theta-otDCS applied during either encoding or the retrieval phases of two AM tasks (Face-Word and Object-Location). The stimulation protocol consisted of an anode over the left PPC (P3) and four surrounding return electrodes (CP1, CP5, PO3, POz) with electrical current oscillating in theta rhythm (5 Hz, 1.5 ± 0.5 mA).

Results

HD-Theta-otDCS stimulation applied during both encoding and retrieval increased AM performance compared to sham control in the Face-Word task. We found no differences between the two active stimulation conditions.

Conclusions

HD-Theta-otDCS showed to be a promising tool for enhancing AM, regardless of the stimulation timing. The results provide further support for our previous findings with bipolar otDCS and confirm that PPC stimulation can induce behaviorally relevant modulation in the memory-related cortico-subcortical networks.

Significance

The presented approach is one step forward towards precision brain stimulation for memory neuromodulation. The novelty lies in the combination of increased focality and function-specific current waveform. Positive results set the ground for further research on HD-theta-otDCS effectiveness in clinical populations.

目的：联想记忆（AM）的下降是由于健康的衰老以及各种神经系统疾病。标准经颅电刺激（tES）方案对AM的促进作用尚无定论，往往缺乏功能特异性和刺激聚焦性。我们测试了高密度电极蒙太奇在左侧后顶叶皮层（PPC）上传递阳极θ振荡调制经颅直流电刺激（high- theta - otdcs）的有效性，旨在以空间聚焦和功能特异性的方式靶向AM。方法：在一个假对照交叉实验中，我们探讨了HD-Theta-otDCS在两个AM任务（人脸-词和物体-定位）的编码和检索阶段的不同效果。刺激方案包括左PPC （P3）上的阳极和周围的四个返回电极（CP1, CP5, PO3, POz），电流以theta节律振荡（5 Hz, 1.5±0.5 mA）。结果：与假对照相比，在编码和检索过程中应用HD-Theta-otDCS刺激可提高AM在Face-Word任务中的表现。我们发现两种主动刺激条件之间没有差异。结论：无论刺激时间如何，HD-Theta-otDCS都是一种很有前途的增强AM的工具。这一结果进一步支持了我们之前关于双相otDCS的研究结果，并证实PPC刺激可以在记忆相关的皮质-皮质下网络中诱导行为相关的调节。意义：提出的方法是向记忆神经调节的精确脑刺激迈出的一步。新颖之处在于增强的聚焦性和功能特定的电流波形的结合。积极的结果为进一步研究HD-theta-otDCS在临床人群中的有效性奠定了基础。

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引用次数: 0

Time-Frequency functional connectivity alterations in Alzheimer’s disease and frontotemporal dementia: An EEG analysis using machine learning 阿尔茨海默病和额颞叶痴呆的时频功能连接改变：使用机器学习的脑电图分析。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.008

Huang Zheng , Han Xiao , Yinan Zhang, Haozhe Jia, Xing Ma, Yiqun Gan

Objective

Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are prevalent neurodegenerative diseases characterized by altered brain functional connectivity (FC), affecting over 100 million people worldwide. This study aims to identify distinct FC patterns as potential biomarkers for differential diagnosis.

Methods

Resting-state EEG data from 36 AD patients, 23 FTD patients, and 29 healthy controls were analyzed using time-frequency and bandpass filtering FC metrics. These metrics were estimated through Pearson’s correlations, mutual information, and phase lag index, and served as input features in a support vector machine (SVM) with Leave-One-Out Cross-Validation for group classification.

Results

Both AD and FTD exhibited significantly decreased FC in the theta band within the frontal lobe and increased FC in the beta band in the posterior regions. Additionally, a decreased FC in central regions at theta band was observed uniquely in AD, but not in FTD. SVM classification accuracies reached 95% for AD and 86% for FTD.

Conclusions

High classification accuracies underscore the potential of these FC alterations as reliable biomarkers for AD and FTD.

Significance

This is the first study to integrate time-frequency and bandpass filtering FC metrics to reveal brain network alterations in AD and FTD, providing new insights for diagnostics and neurodegenerative pathologies.

目的：阿尔茨海默病（AD）和额颞叶痴呆（FTD）是以脑功能连接改变（FC）为特征的常见神经退行性疾病，影响全球超过1亿人。本研究旨在确定不同的FC模式作为鉴别诊断的潜在生物标志物。方法：采用时频和带通滤波FC指标对36例AD患者、23例FTD患者和29例健康对照的静息状态EEG数据进行分析。这些指标通过Pearson的相关性、互信息和相位滞后指数进行估计，并作为支持向量机（SVM）的输入特征，通过Leave-One-Out交叉验证进行群体分类。结果：AD和FTD均表现出额叶θ波段的FC显著降低，后叶β波段的FC显著增加。此外，仅在AD中观察到θ波段中央区域的FC减少，而在FTD中则没有。SVM对AD的分类准确率达到95%，对FTD的分类准确率达到86%。结论：高分类准确性强调了这些FC改变作为AD和FTD可靠生物标志物的潜力。意义：这是首次将时频和带通滤波FC指标结合起来，揭示AD和FTD的脑网络改变，为诊断和神经退行性病理提供新的见解。

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引用次数: 0

Peripheral nerve excitability abnormalities in Neuronal Intranuclear Inclusion Disease: Assessment with histopathological analysis 神经元核内包涵病的周围神经兴奋性异常：组织病理学分析评估。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.013

Yusuke Osaki , Hiroyuki Nodera , Ryota Sato , Shotaro Haji , Koji Fujita , Ryosuke Miyamoto , Kohei Muto , Hiroki Yamazaki , Hiroyuki Morino , Takashi Kanda , Shigeo Murayama , Ryuji Kaji , Yuishin Izumi

Objective

Neuronal Intranuclear Inclusion Disease (NIID) is a neurodegenerative disease affecting the central and peripheral nerves. We aimed to assess the pathophysiological features of peripheral nerve dysfunction in NIID.

Methods

We observed six unrelated NIID patients through clinical records, nerve conduction studies, and multiple measures of motor nerve excitability. Additionally, we reviewed one NIID patientt who underwent a nerve biopsy. Control measures were obtained from 22 age-matched normal subjects.

Results

The NIID patients exhibited mild conduction slowing and distinct nerve excitability abnormalities, including a significant decrease in excitability through hyperpolarizing threshold electrotonus (TE) and increased overshoots in both depolarizing and hyperpolarizing conditions. Histopathology revealed thinly myelinated fibers and axonal degeneration. Mathematical modeling suggested that reduced leak conductance was the key factor contributing to the observed excitability changes.

Conclusions

The findings indicate that NIID involves a complex interplay of axonal degeneration and myelin dysfunction, leading to unique peripheral nerve excitability changes. These results provide new insights into the pathophysiology of NIID.

Significance

Nerve excitability testing offers insight into particular axonal excitability abnormalities especially combined with histopathologic studies.

目的：神经元核内包涵病（NIID）是一种影响中枢和周围神经的神经退行性疾病。我们旨在评估NIID周围神经功能障碍的病理生理特征。方法：我们通过临床记录、神经传导研究和多种运动神经兴奋性测量来观察6例不相关的NIID患者。此外，我们回顾了一位接受神经活检的NIID患者。对照措施来自22名年龄匹配的正常受试者。结果：NIID患者表现出轻微的传导减慢和明显的神经兴奋性异常，包括通过超极化阈值电张力（TE）引起的兴奋性显著降低以及去极化和超极化条件下的过调增加。组织病理学显示髓鞘纤维薄，轴突变性。数学模型表明，泄漏电导的降低是导致所观察到的兴奋性变化的关键因素。结论：研究结果表明，NIID涉及轴突变性和髓鞘功能障碍的复杂相互作用，导致独特的周围神经兴奋性变化。这些结果为NIID的病理生理学提供了新的见解。意义：神经兴奋性测试提供了对特定轴突兴奋性异常的见解，特别是结合组织病理学研究。

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引用次数: 0

Tracking local and distant cortico-cortical interactions in brain tumor patients: A proof of concept TMS-EEG study 追踪脑肿瘤患者局部和远端皮质-皮质相互作用：TMS-EEG研究的概念验证。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.005

Chiara Mazzi , Elena Bertacco , Nicolò Cardobi , Alessandro Boaro , Francesco Sala , Silvia Savazzi , Chiara Bagattini

引用次数: 0

Comment on “Tonic stretch reflex threshold as a measure of disordered motor control and spasticity – A critical review” by Levin et al. (2024) 对Levin等人（2024）的“张力拉伸反射阈值作为运动控制紊乱和痉挛的测量-一项重要的回顾”的评论。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.016

John W. Chow, Stuart A. Yablon, Dobrivoje S. Stokic

引用次数: 0

Reply to: Commentary: Tonic stretch reflex threshold as a measure of disordered motor control and spasticity – A critical review 回复：评论：张力拉伸反射阈值作为运动控制紊乱和痉挛的测量-一个重要的回顾。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.017

Mindy F. Levin, Daniele Piscitelli, Joy Khayat

引用次数: 0

Self-regulation of slow cortical potential and seizure suppression by scalp electroencephalography: Early prediction of therapeutic efficacy 头皮脑电图对皮层慢电位的自我调节和癫痫抑制：治疗效果的早期预测。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.11.018

Tomoyuki Fumuro , Masao Matsuhashi , Masako Kinoshita , Riki Matsumoto , Ryosuke Takahashi , Akio Ikeda

Objective

Seizure suppression using the neurofeedback (NFB) method by self-regulation of scalp-recorded slow cortical potential (SCP) is effective for patients with refractory focal epilepsy. However, the prolonged training period required prevents it from wider implementation as the standard treatment in clinical practice. Therefore, we examined whether it would be appropriate to shorten the training period, in spite of the small number of patients.

Methods

12 patients participated the NFB training. 1 course of NFB training consisted of 35 sessions divided into 2 phases. After each phase we evaluated whether each patient acquired NFB control, and seizure reduction was assessed compared to that before training.

Results

Of 11 patients who completed the first training phase, 4 showed reduced post-training seizure frequency, of whom 3 could regulate the SCP polarity (NFB control). Of the remaining 7, 2 acquired NFB control during the second training phase but seizure frequency did not decrease. Furthermore, the other 5 did not acquire NFB control, and seizure frequency did not decrease.

Conclusions

Patients who acquired NFB control within a short period, i.e., 3 weeks, were more likely to exhibit a lower post-training seizure frequency.

Significance

SCP self-regulation can be acquired within a short period and is associated with seizure reduction.

目的：应用脑皮层慢电位（SCP）自我调节的神经反馈（NFB）方法抑制难治性局灶性癫痫的发作是有效的。然而，所需的长期培训时间阻碍了它作为临床实践中的标准治疗的广泛实施。因此，尽管患者数量较少，我们还是研究了缩短培训时间是否合适。方法：12例患者参加NFB培训。1期NFB训练共35节，分为2个阶段。每个阶段结束后，我们评估每位患者是否获得NFB控制，并评估与训练前相比癫痫发作减少情况。结果：11例完成第一期训练的患者中，4例训练后癫痫发作频率降低，其中3例可以调节SCP极性（NFB控制）。在剩下的7人中，2人在第二训练阶段获得了NFB控制，但癫痫发作频率没有下降。此外，其他5例未获得NFB控制，癫痫发作频率未降低。结论：在短时间内（即3周）获得NFB控制的患者更有可能表现出较低的训练后癫痫发作频率。意义：SCP自我调节可在短时间内获得，并与癫痫发作减少有关。

{"title":"Self-regulation of slow cortical potential and seizure suppression by scalp electroencephalography: Early prediction of therapeutic efficacy","authors":"Tomoyuki Fumuro , Masao Matsuhashi , Masako Kinoshita , Riki Matsumoto , Ryosuke Takahashi , Akio Ikeda","doi":"10.1016/j.clinph.2024.11.018","DOIUrl":"10.1016/j.clinph.2024.11.018","url":null,"abstract":"<div><h3>Objective</h3><div>Seizure suppression using the neurofeedback (NFB) method by self-regulation of scalp-recorded slow cortical potential (SCP) is effective for patients with refractory focal epilepsy. However, the prolonged training period required prevents it from wider implementation as the standard treatment in clinical practice. Therefore, we examined whether it would be appropriate to shorten the training period, in spite of the small number of patients.</div></div><div><h3>Methods</h3><div>12 patients participated the NFB training. 1 course of NFB training consisted of 35 sessions divided into 2 phases. After each phase we evaluated whether each patient acquired NFB control, and seizure reduction was assessed compared to that before training.</div></div><div><h3>Results</h3><div>Of 11 patients who completed the first training phase, 4 showed reduced post-training seizure frequency, of whom 3 could regulate the SCP polarity (NFB control). Of the remaining 7, 2 acquired NFB control during the second training phase but seizure frequency did not decrease. Furthermore, the other 5 did not acquire NFB control, and seizure frequency did not decrease.</div></div><div><h3>Conclusions</h3><div>Patients who acquired NFB control within a short period, i.e., 3 weeks, were more likely to exhibit a lower post-training seizure frequency.</div></div><div><h3>Significance</h3><div>SCP self-regulation can be acquired within a short period and is associated with seizure reduction.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 182-191"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reorganization of pragmatic language networks in patients with temporal lobe epilepsy 颞叶癫痫患者语用网络的重组。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.012

Bautista Elizalde Acevedo , Silvia Kochen , Lucy Alba-Ferrara , Mariana Bendersky

Objective

To investigate the neural networks involved in idiomatic expressions (IE) comprehension in healthy controls and patients with drug-resistant temporal lobe epilepsy (TLE), with a functional magnetic resonance imaging (fMRI) task.

Methods

Thirty-two patients with TLE (left or right) and seventeen healthy controls were evaluated. Activated nodes in the fMRI task were defined as Regions of Interest (ROIs) for a posterior functional connectivity analysis.

Results

All participants completed the task successfully. We found a bilateral fronto-temporal network, lateralized to the right, during IE processing in the overall sample. Compared to controls, patients additionally activated frontal, temporal, and insular areas in both hemispheres. Controls exhibited fewer connections but greater inhibitory connectivity, while the opposite (more connections and increased excitatory connectivity) occurred in patients. Compared to controls, TLE patients recruited additional brain areas on top of the expected bilateral frontotemporal network. The connectivity analysis revealed that controls exhibited more effective inhibitory connectivity, with more modular ROIs. In contrast, patients demonstrated greater excitatory connectivity.

Conclusion

The results suggest compensatory neural recruitment in additional areas in TLE during IE comprehension.

Significance

Exacerbated connections in TLE may reflect the need to recruit alternative regions, resulting in higher costs and lower efficiency of the neural network.

目的：通过功能磁共振成像（fMRI）研究正常对照和耐药颞叶癫痫（TLE）患者习语表达理解的神经网络功能。方法：对32例TLE患者（左、右）和17例健康对照进行评价。fMRI任务中的激活节点被定义为感兴趣区域（roi），用于后验功能连接分析。结果：所有参与者都成功完成了任务。在整个样本的IE处理过程中，我们发现了一个向右偏侧的双侧额颞网络。与对照组相比，患者在两个大脑半球的额叶、颞叶和岛叶区域被额外激活。对照组表现出较少的连接，但更大的抑制性连接，而患者则相反（更多的连接和增加的兴奋性连接）。与对照组相比，TLE患者在预期的双侧额颞叶网络之上增加了额外的脑区域。连通性分析显示，对照组表现出更有效的抑制连通性，具有更多的模块化roi。相反，患者表现出更大的兴奋性连通性。结论：在IE理解过程中，颞叶有额外区域的代偿性神经补充。意义：TLE连接加剧可能反映了需要招募替代区域，从而导致神经网络成本增加，效率降低。

{"title":"Reorganization of pragmatic language networks in patients with temporal lobe epilepsy","authors":"Bautista Elizalde Acevedo , Silvia Kochen , Lucy Alba-Ferrara , Mariana Bendersky","doi":"10.1016/j.clinph.2024.12.012","DOIUrl":"10.1016/j.clinph.2024.12.012","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the neural networks involved in idiomatic expressions (IE) comprehension in healthy controls and patients with drug-resistant temporal lobe epilepsy (TLE), with a functional magnetic resonance imaging (fMRI) task.</div></div><div><h3>Methods</h3><div>Thirty-two patients with TLE (left or right) and seventeen healthy controls were evaluated. Activated nodes in the fMRI task were defined as Regions of Interest (ROIs) for a posterior functional connectivity analysis.</div></div><div><h3>Results</h3><div>All participants completed the task successfully. We found a bilateral fronto-temporal network, lateralized to the right, during IE processing in the overall sample. Compared to controls, patients additionally activated frontal, temporal, and insular areas in both hemispheres. Controls exhibited fewer connections but greater inhibitory connectivity, while the opposite (more connections and increased excitatory connectivity) occurred in patients. Compared to controls, TLE patients recruited additional brain areas on top of the expected bilateral frontotemporal network. The connectivity analysis revealed that controls exhibited more effective inhibitory connectivity, with more modular ROIs. In contrast, patients demonstrated greater excitatory connectivity.</div></div><div><h3>Conclusion</h3><div>The results suggest compensatory neural recruitment in additional areas in TLE during IE comprehension.</div></div><div><h3>Significance</h3><div>Exacerbated connections in TLE may reflect the need to recruit alternative regions, resulting in higher costs and lower efficiency of the neural network.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 194-205"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep spindle variation in patients with Parkinson’s disease on first nights of sub-optimal deep brain stimulation 帕金森病患者在次优深部脑刺激第一夜的睡眠纺锤体变化

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.11.020

Rig Das , Stephen V. Gliske , Dulce Maroni , Miguel Situ-Kcomt , Leslie C West , Michael O Summers , Siqun Tang , Pavan A. Vaswani , Casey H. Halpern , John A. Thompson , Clete A. Kushida , Aviva Abosch

Objective

Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) is a common treatment for motor symptoms of Parkinson’s disease but its influence on non-motor symptoms is less clear. Sleep spindles are known to be reduced in patients with Parkinson’s disease, but the effect of STN DBS is unknown. The objective of our study was to address this knowledge gap.

Method

Polysomnograms were recorded for three consecutive nights in 15 patients with advanced Parkinson’s disease (11 male, 4 female; age: 53–75 years), including at least one night each of unilateral STN DBS stimulation ON and OFF. Stimulation ON was set to 70 % of clinical amplitude to mitigate sleep being altered via changing motor symptoms or due to patient awareness of stimulation. Sleep spindles were detected in electroencephalogram (EEG) data by two previously published, validated automated sleep spindle detection algorithms: Ferrarelli et al. (2007) and Martin et al. (2013).

Results

Sleep spindle density was higher during stimulation ON than OFF nights in 11 of 12 subjects using either sleep spindle detection algorithm (p<=0.01, Wilcoxon rank sum). Stimulation ON versus OFF had no statistically significant effect on sleep spindle duration or amplitude.

Conclusion

Our analysis indicates that a single night of sub-optimal STN stimulation significantly increases sleep spindle density in Parkinson’s disease patients.

Significance

These results further our understanding of how DBS impacts non-motor symptoms of Parkinson’s disease.

目的：针对丘脑底核的脑深部电刺激（DBS）是治疗帕金森病运动症状的常用方法，但其对非运动症状的影响尚不清楚。已知帕金森病患者的睡眠纺锤波减少，但STN DBS的影响尚不清楚。我们研究的目的是解决这一知识差距。方法：对15例晚期帕金森病患者(男11例，女4例；年龄：53-75岁)，包括至少一个晚上的单侧STN DBS刺激ON和OFF。刺激ON被设置为临床振幅的70%，以减轻通过改变运动症状或由于患者对刺激的意识而改变的睡眠。睡眠纺锤波在脑电图（EEG）数据中是通过两种先前发表的、经过验证的自动睡眠纺锤波检测算法检测到的：Ferrarelli等人（2007）和Martin等人（2013）。结果：无论使用哪种睡眠纺锤波检测算法，12名受试者中有11名受试者的睡眠纺锤波密度在打开刺激的夜晚都高于关闭刺激的夜晚(结论：我们的分析表明，单晚次优的STN刺激显著增加了帕金森病患者的睡眠纺锤波密度。意义：这些结果进一步加深了我们对DBS如何影响帕金森病非运动症状的理解。

{"title":"Sleep spindle variation in patients with Parkinson’s disease on first nights of sub-optimal deep brain stimulation","authors":"Rig Das , Stephen V. Gliske , Dulce Maroni , Miguel Situ-Kcomt , Leslie C West , Michael O Summers , Siqun Tang , Pavan A. Vaswani , Casey H. Halpern , John A. Thompson , Clete A. Kushida , Aviva Abosch","doi":"10.1016/j.clinph.2024.11.020","DOIUrl":"10.1016/j.clinph.2024.11.020","url":null,"abstract":"<div><h3>Objective</h3><div>Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) is a common treatment for motor symptoms of Parkinson’s disease but its influence on non-motor symptoms is less clear. Sleep spindles are known to be reduced in patients with Parkinson’s disease, but the effect of STN DBS is unknown. The objective of our study was to address this knowledge gap.</div></div><div><h3>Method</h3><div>Polysomnograms were recorded for three consecutive nights in 15 patients with advanced Parkinson’s disease (11 male, 4 female; age: 53–75 years), including at least one night each of unilateral STN DBS stimulation ON and OFF. Stimulation ON was set to 70 % of clinical amplitude to mitigate sleep being altered via changing motor symptoms or due to patient awareness of stimulation. Sleep spindles were detected in electroencephalogram (EEG) data by two previously published, validated automated sleep spindle detection algorithms: Ferrarelli et al. (2007) and Martin et al. (2013).</div></div><div><h3>Results</h3><div>Sleep spindle density was higher during stimulation ON than OFF nights in 11 of 12 subjects using either sleep spindle detection algorithm (p<=0.01, Wilcoxon rank sum). Stimulation ON versus OFF had no statistically significant effect on sleep spindle duration or amplitude.</div></div><div><h3>Conclusion</h3><div>Our analysis indicates that a single night of sub-optimal STN stimulation significantly increases sleep spindle density in Parkinson’s disease patients.</div></div><div><h3>Significance</h3><div>These results further our understanding of how DBS impacts non-motor symptoms of Parkinson’s disease.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 91-97"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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