Clinical Neurophysiology最新文献

英文中文

The seizure onset zone: More than just the "onset" zone. 癫痫发作区：不仅仅是 "发作 "区

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-10-18 DOI: 10.1016/j.clinph.2024.10.002

Katherine A Zarroli, Ramon Edmundo D Bautista

引用次数: 0

Resting-state EEG spectral and fractal features in dementia with Lewy bodies with and without visual hallucinations 伴有或不伴有视幻觉的路易体痴呆症静息态脑电图频谱和分形特征。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-10-16 DOI: 10.1016/j.clinph.2024.10.004

Objective

Complex visual hallucinations (VH) are a core feature of dementia with Lewy bodies (DLB), though they may not occur in all patients. Power spectral density (PSD) analysis of resting-state EEG (rs-EEG) shows associations between some frequency bands (e.g., theta), individual alpha frequency (IAF) and VH. However, new tools that improve early differential diagnosis and symptom-based stratification with higher sensitivity and specificity, even within the DLB population, are desirable. We aimed to assess differences in rs-EEG data between DLB patients with VH (DLB-VH+) and without VH (DLB-VH-), comparing innovative non-linear approaches with more traditional linear ones.

Methods

We retrospectively analyzed rs-EEG recordings of DLB-VH+, DLB-VH-, Alzheimer’s disease patients and age-matched healthy controls. EEG was analyzed using the nonlinear Higuchi’s Fractal Dimension (FD) measure, and the results were compared with those of entropy and standard linear methods based on PSD and IAF.

Results

Only the FD measure could discriminate between DLB-VH+ and DLB-VH-.

Conclusions

In conclusion, rs-EEG differences between DLB-VH+ and DLB-VH- are better characterized by FD analysis than by a more traditional power spectrum approach.

Significance

This suggests that the presence of complex VH is associated with less complex brain dynamics at rest, as reflected by the FD measure.

目的：复杂视幻觉（VH）是路易体痴呆（DLB）的一个核心特征，但并非所有患者都会出现。静息态脑电图（rs-EEG）的功率谱密度（PSD）分析表明，某些频段（如θ）、单个α频率（IAF）与VH之间存在关联。然而，即使是在 DLB 患者中，也需要能提高早期鉴别诊断和基于症状分层的灵敏度和特异性的新工具。我们旨在评估有 VH 的 DLB 患者（DLB-VH+）和无 VH 的 DLB 患者（DLB-VH-）之间的 rs-EEG 数据差异，比较创新的非线性方法和更传统的线性方法：我们回顾性分析了 DLB-VH+、DLB-VH-、阿尔茨海默病患者和年龄匹配的健康对照者的 rs-EEG 记录。使用非线性樋口分形维度（FD）测量法分析脑电图，并将结果与熵法以及基于 PSD 和 IAF 的标准线性方法进行比较：结果：只有 FD 测量能区分 DLB-VH+ 和 DLB-VH-：总之，与更传统的功率谱方法相比，FD分析能更好地描述DLB-VH+和DLB-VH-之间的rs-EEG差异：意义：这表明，复杂 VH 的存在与静息状态下较不复杂的大脑动力学有关，这一点在 FD 测量中得到了反映。

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引用次数: 0

Intraoperative corticobulbar motor evoked potentials and blink reflex during skull base surgery: Significance of anesthetic regime 颅底手术中的术中皮质布巴运动诱发电位和眨眼反射：麻醉机制的意义。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-10-15 DOI: 10.1016/j.clinph.2024.10.001

引用次数: 0

Long-term motor learning in focal hand dystonia 局灶性手部肌张力障碍的长期运动学习

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-10-09 DOI: 10.1016/j.clinph.2024.09.024

Objective

Because focal hand dystonia usually occurs in the over-learned stage, it would be valuable to know long-term motor learning characteristics and underlying pathophysiological features that might predispose to dystonia.

Methods

We conducted a case-control exploratory study of 15 visits over 12 weeks in the non-affected hand of a 4-finger sequence of 8 key presses in eight patients with FHD compared with eight age- and sex-matched, healthy volunteers (HVs). We studied the behavioral data and the physiological changes of the brain, including motor cortical excitability and cortical oscillations.

Results

There was no significant difference in the time to reach 100 % accuracy between FHD and HV during the 80-day follow-up period. There was a statistically significant difference in the accuracy of sequential finger movement tasks between patients with FHD compared with HVs over 12 weeks, but post-hoc analysis with multiple comparion correction did not show difference. There were no significant differences in recruitment curve changes and task-related power changes of alpha and beta bands.

Conclusion

Over 12 weeks, FHD have motor learning capacity comparable to HVs and do not show pathophysiological abnormalities.

Significance

Further studies would be valuable with more patients, more extended periods of practice, and more detailed electrophysiological explorations.

目的由于局灶性手肌张力障碍通常发生在过度学习阶段，因此了解长期的运动学习特征以及可能导致肌张力障碍的潜在病理生理特点非常有价值。方法我们对8名FHD患者与8名年龄和性别匹配的健康志愿者（HVs）进行了一项病例对照探索性研究，在12周内对8个按键的4指序列进行了15次访问。我们研究了行为数据和大脑的生理变化，包括运动皮层兴奋性和皮层振荡。结果在 80 天的随访期间，FHD 和 HV 达到 100 % 准确率的时间没有显著差异。在12周内，FHD患者与HV患者在连续手指运动任务的准确性上存在显著统计学差异，但经多重比较校正的事后分析未显示出差异。结论在 12 周内，FHD 患者的运动学习能力与 HVs 相当，且未出现病理生理异常。

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引用次数: 0

Serial compound muscle action potential recordings in Duchenne muscular dystrophy 杜氏肌营养不良症的序列复合肌肉动作电位记录

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-10-09 DOI: 10.1016/j.clinph.2024.09.025

引用次数: 0

Abnormal individualized functional connectivity: A potential stimulation target for pediatric tourette syndrome 异常的个性化功能连接：小儿抽动秽语综合征的潜在刺激目标

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-10-09 DOI: 10.1016/j.clinph.2024.09.026

Objective

In order to examine whether individualized peak functional connectivity could potentially serve as a target for repetitive transcranial magnetic stimulation (rTMS) therapy, we investigated the location of peak functional connectivity (FC) between the cortical motor area and the key brain region, the globus pallidus internus (GPi), in Tourette syndrome, and explored the relationship between the severity of the disease and these aberrant functional connections.

Methods

The study involved a cohort of 103 children diagnosed with Tourette syndrome and 66 age-matched typically developing children. The GPi was served as the seed, and the study compared individualized peak FC strength in the supplementary motor area (SMA) and premotor area between the two groups. Spatial distribution of peak FC in the motor area and GPi-based voxel-wise FC were also analyzed.

Results

Children with Tourette syndrome exhibited lower peak FC in the left SMA when using left GPi as the seed. This reduction in peak FC demonstrated a significant and negative correlation with the Yale Global Tic Severity Scale scores.

Conclusions

SMA-GPi FC is one of the key pathological circuit in Tourette syndrome.

Significance

The individual peak FC location in the left SMA potentially serve as stimulation targets for rTMS treatment of TS.

研究目的为了研究个体化的峰值功能连接是否有可能成为重复经颅磁刺激（rTMS）疗法的目标，我们调查了图雷特综合征患者皮层运动区与关键脑区苍白球内侧（GPi）之间峰值功能连接（FC）的位置，并探讨了疾病严重程度与这些异常功能连接之间的关系：研究对象包括 103 名确诊为妥瑞症的儿童和 66 名年龄匹配的发育正常儿童。研究以 GPi 为种子，比较了两组儿童辅助运动区（SMA）和前运动区的个体化 FC 峰值强度。研究还分析了运动区FC峰值的空间分布以及基于GPi的体素FC：结果：以左侧 GPi 为种子，图雷特综合征患儿左侧 SMA 的 FC 峰值较低。FC峰值的降低与耶鲁全球抽搐严重程度量表评分呈显著负相关：结论：SMA-GPi FC是妥瑞症的关键病理回路之一：意义：左侧SMA的单个FC峰值位置可作为经颅磁刺激治疗TS的刺激目标。

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引用次数: 0

Standardized Kalman filtering for dynamical source localization of concurrent subcortical and cortical brain activity 标准化卡尔曼滤波用于并发皮层下和皮层脑活动的动态源定位

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-09-28 DOI: 10.1016/j.clinph.2024.09.021

Objective

We introduce standardized Kalman filtering (SKF) as a new spatiotemporal method for tracking brain activity. Via the Kalman filtering scheme, the computational workload is low, and by spatiotemporal standardization, we reduce the depth bias of non-standardized Kalman filtering (KF).

Methods

We describe the standardized KF methodology for spatiotemporal tracking from the Bayesian perspective. We construct a realistic simulation setup that resembles activity due to somatosensory evoked potential (SEP) to validate the proposed methodology before we run our tests using real SEP data.

Results

In the experiments, SKF was compared with standardized low-resolution brain electromagnetic tomography (sLORETA) and the non-standardized KF. SKF localized the cortical and subcortical SEP originators appropriately and tracked P20/N20 originators for investigated signal-to-noise ratios (25, 15, and 5 dB). sLORETA distinguished those for 25 and 15 dB suppressing the subcortical originators. KF tracked only the evolution of cortical activity but mislocalized it.

Conclusions

The numerical results suggest that SKF inherits the estimation accuracy of sLORETA and traceability of KF while producing focal estimates for SEP originators.

Significance

SKF could help study time-evolving brain activities and localize landmarks with a deep contributor or when there is no prior knowledge of evolution.

目的我们引入标准化卡尔曼滤波（SKF）作为一种新的时空追踪大脑活动的方法。通过卡尔曼滤波方案，计算工作量低，而且通过时空标准化，我们减少了非标准化卡尔曼滤波（KF）的深度偏差。方法我们从贝叶斯的角度描述了时空跟踪的标准化卡尔曼滤波方法。在使用真实的躯体感觉诱发电位（SEP）数据进行测试之前，我们构建了一个类似于躯体感觉诱发电位（SEP）活动的真实模拟装置，以验证所提出的方法。结果在实验中，SKF 与标准化低分辨率脑电磁断层扫描（sLORETA）和非标准化 KF 进行了比较。SKF 对皮层和皮层下 SEP 起源进行了适当定位，并跟踪了调查信噪比（25、15 和 5 dB）的 P20/N20 起源。结论数值结果表明，SKF 继承了 sLORETA 的估计精度和 KF 的可追溯性，同时还能对 SEP 起源进行重点估计。

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引用次数: 0

tDCS and local scalp cooling do not change corticomotor and intracortical excitability in healthy humans tDCS 和局部头皮冷却不会改变健康人的皮质运动和皮质内兴奋性。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-09-28 DOI: 10.1016/j.clinph.2024.09.023

Objective

Scalp cooling might increase the long-term potentiation (LTP)-like effect of transcranial direct current stimulation (tDCS) by reducing the threshold for after-effects according to metaplasticity and increasing electrical current density reaching the cortical neurons. We aimed to investigate whether priming scalp cooling potentiates the tDCS after-effect on motor cortex excitability.

Methods

This study had a randomized, parallel-arms, sham-controlled, double-blinded design with an adequately powered sample of 105 healthy subjects. Corticomotor and intracortical excitability were assessed with motor evoked potentials (MEP) from transcranial magnetic stimulation (TMS) in short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) paradigms. Subjects were randomly allocated into six intervention groups, including anodal and cathodal tDCS (1-mA/20-min), scalp cooling, and sham. MEPs were recorded before, immediately, and 15 min after the interventions.

Results

We did not observe changes in MEP amplitude from single-pulse TMS, SICI, and ICF with any intervention protocol.

Conclusion

Anodal and cathodal tDCS did not have an LTP-like neuromodulatory effect on corticospinal and did not provide detectable GABAergic and glutamatergic neurotransmission changes, which were not influenced by priming scalp cooling.

Significance

We provide strong evidence that tDCS (1-mA/20-min) does not alter corticomotor and intracortical excitability with or without priming scalp cooling.

目的头皮冷却可能会提高经颅直流电刺激（tDCS）的长期电位（LTP）样效应，其方法是根据元弹性降低后效应阈值并增加到达皮层神经元的电流密度。我们的目的是研究头皮冷却是否会增强 tDCS 对运动皮层兴奋性的后效应：本研究采用随机、平行臂、假对照、双盲设计，对 105 名健康受试者进行了充分的抽样调查。在短间隔皮层内抑制（SICI）和皮层内促进（ICF）范例中，通过经颅磁刺激（TMS）产生的运动诱发电位（MEP）评估皮层运动和皮层内兴奋性。受试者被随机分配到六个干预组，包括阳极和阴极 tDCS（1-mA/20-min）、头皮冷却和假干预。分别在干预前、干预后和干预后 15 分钟记录 MEPs：结果：在任何干预方案下，我们都没有观察到单脉冲 TMS、SICI 和 ICF 对 MEP 振幅的影响：结论：正极和负极 tDCS 对皮质脊髓没有 LTP 样的神经调节作用，也没有提供可检测到的 GABA 能和谷氨酸能神经传递变化，这些变化不受引物头皮冷却的影响：我们提供了强有力的证据，证明无论是否使用头皮冷却引物，tDCS（1-mA/20-min）都不会改变皮质运动和皮质内的兴奋性。

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引用次数: 0

Burst suppression like EEG pattern under levetiracetam without anaesthesia or cerebral hypoxia 在没有麻醉或脑缺氧的情况下，左乙拉西坦会产生类似脉冲抑制的脑电图模式。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-09-27 DOI: 10.1016/j.clinph.2024.09.022

引用次数: 0

Listening for the beat: Low intensity ultrasound modulates heartbeat evoked potentials. 聆听心跳低强度超声波调节心跳诱发电位

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2024-09-26 DOI: 10.1016/j.clinph.2024.09.020

Noah S Philip, Amanda R Arulpragasam

引用次数: 0

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