Pub Date : 2018-05-10DOI: 10.15406/JNSK.2018.08.00301
N. Koberskaya
the Russian Academy of the Medical Sciences, by the end of the acute period of the blood-stroke aphasia is reported in 36% of the cases, while dysarthria is reported only in 14% of the cases.13–17 Speech disorder is the cause of the social and mental maladjustment of the patients, it significantly reduces their communicative capabilities, everyday vitality, contributes to their social exclusion. Recovery after the post-stroke speech disorder is a daunting task and depends on many factors. Unfortunately, the speech disorder is very persistent and the full recovery usually takes from 2 to 6 years.14–16,18,19 The presence of the gross total sensorimotor aphasia of the patients having the acute period of the blood-stroke (especially, if these defects are refractory during 3-4 months) is an adverse factor for the speech disorder recovery.20,21 With no regard of the severity of the blood-stroke and the starting date of the speech corrective therapy, speech function recovery in usually poor. In most cases, providing the long systematic psychological corrective therapy by the speech therapist-afasiologist can only induce the limited improvement of the speech function.21 In view of all these factors, the drug treatment plays a major role in the process of the post-stroke patients’ rehabilitation. There are no specific recommendations concerning the treatment of such patients in the present literature on the post-stroke cognitive defects. That’s why, specialists follow general approaches to treat the patients with bloodstroke (vascular risk factors correction, antihypertensive therapy, statins etc.). There are a lot of medications used for the recovery of the cognitive functions of the patients with the acute cerebrovascular accident but all of them could be divided into 4 groups: 1) medications that effect on the certain neurotransmitter systems; 2) medications with neurotrophic action; 3) medications with neurometabolic action; 4) medications with vasoactive action. Unfortunately, most of the medications used in Russian clinical practice have no evidencebased guidelines there are no results of placebo-controlled studies, that’s why, there is no objective evidence of the effectiveness. Today there is no consensus on the effectiveness of speech disorder’s drug therapy. In recent years many researches, studying the effect of the number of medications on neurorehabilitation’s effectiveness, are carried out. The series of scientific researches have proved positive effect of the Paricetam. The Paricetam administration at a dose of 2400 mg twice per day had a positive effect on the expressive speech indicators.22,23 According to Berthier et al.,24 Donepezil use at a dose of 10 mg once daily combined with weekly two hour speech corrective therapy improved the parameters of the nominal speech function and reduced the severity of post-stroke aphasia.24 According to the results of the randomized placebo-controlled studies that were performed by Walker-Batson et al.
{"title":"Treatment of the post-stroke speech disorders in the patients with cardiac and cerebrovascular pathology","authors":"N. Koberskaya","doi":"10.15406/JNSK.2018.08.00301","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00301","url":null,"abstract":"the Russian Academy of the Medical Sciences, by the end of the acute period of the blood-stroke aphasia is reported in 36% of the cases, while dysarthria is reported only in 14% of the cases.13–17 Speech disorder is the cause of the social and mental maladjustment of the patients, it significantly reduces their communicative capabilities, everyday vitality, contributes to their social exclusion. Recovery after the post-stroke speech disorder is a daunting task and depends on many factors. Unfortunately, the speech disorder is very persistent and the full recovery usually takes from 2 to 6 years.14–16,18,19 The presence of the gross total sensorimotor aphasia of the patients having the acute period of the blood-stroke (especially, if these defects are refractory during 3-4 months) is an adverse factor for the speech disorder recovery.20,21 With no regard of the severity of the blood-stroke and the starting date of the speech corrective therapy, speech function recovery in usually poor. In most cases, providing the long systematic psychological corrective therapy by the speech therapist-afasiologist can only induce the limited improvement of the speech function.21 In view of all these factors, the drug treatment plays a major role in the process of the post-stroke patients’ rehabilitation. There are no specific recommendations concerning the treatment of such patients in the present literature on the post-stroke cognitive defects. That’s why, specialists follow general approaches to treat the patients with bloodstroke (vascular risk factors correction, antihypertensive therapy, statins etc.). There are a lot of medications used for the recovery of the cognitive functions of the patients with the acute cerebrovascular accident but all of them could be divided into 4 groups: 1) medications that effect on the certain neurotransmitter systems; 2) medications with neurotrophic action; 3) medications with neurometabolic action; 4) medications with vasoactive action. Unfortunately, most of the medications used in Russian clinical practice have no evidencebased guidelines there are no results of placebo-controlled studies, that’s why, there is no objective evidence of the effectiveness. Today there is no consensus on the effectiveness of speech disorder’s drug therapy. In recent years many researches, studying the effect of the number of medications on neurorehabilitation’s effectiveness, are carried out. The series of scientific researches have proved positive effect of the Paricetam. The Paricetam administration at a dose of 2400 mg twice per day had a positive effect on the expressive speech indicators.22,23 According to Berthier et al.,24 Donepezil use at a dose of 10 mg once daily combined with weekly two hour speech corrective therapy improved the parameters of the nominal speech function and reduced the severity of post-stroke aphasia.24 According to the results of the randomized placebo-controlled studies that were performed by Walker-Batson et al.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125028484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-05-08DOI: 10.15406/jnsk.2018.08.00300
A. Shubbar, Ali R Dehdashtian, M. A. Arif, Khurram A Siddiqui
Posterior reversible encephalopathy syndrome (PRES) is a rare clinico-radiological entity characterized by rapid onset of symptoms including headache, seizures, altered consciousness, and visual disturbance. Associated with white matter changes predominantly affecting the posterior parietal and occipital lobes of the brain on neuro imaging. Several conditions have been associated with PRES. The well documented are hypertension; eclampsia, immunosuppressive and cytotoxic treatments, autoimmune diseases and infections/sepsis. There are as well numerous associations rarely or anecdotally reported. It is particularly important not to exclude PRES as a possible diagnosis when we have the appropriate clinical presentation accompanied by the typical radiological findings. It is an increasingly recognized disorder, with a wide clinical spectrum of both symptoms and triggers, and yet it remains poorly understood. We report unusual reasons of PRES and findings.
{"title":"Unusual reasons and imaging finding in (PRES) posterior reversible encephalopathy syndromes","authors":"A. Shubbar, Ali R Dehdashtian, M. A. Arif, Khurram A Siddiqui","doi":"10.15406/jnsk.2018.08.00300","DOIUrl":"https://doi.org/10.15406/jnsk.2018.08.00300","url":null,"abstract":"Posterior reversible encephalopathy syndrome (PRES) is a rare clinico-radiological entity characterized by rapid onset of symptoms including headache, seizures, altered consciousness, and visual disturbance. Associated with white matter changes predominantly affecting the posterior parietal and occipital lobes of the brain on neuro imaging. Several conditions have been associated with PRES. The well documented are hypertension; eclampsia, immunosuppressive and cytotoxic treatments, autoimmune diseases and infections/sepsis. There are as well numerous associations rarely or anecdotally reported. It is particularly important not to exclude PRES as a possible diagnosis when we have the appropriate clinical presentation accompanied by the typical radiological findings. It is an increasingly recognized disorder, with a wide clinical spectrum of both symptoms and triggers, and yet it remains poorly understood. We report unusual reasons of PRES and findings.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132352493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-05-07DOI: 10.15406/jnsk.2018.08.00299
G. Tabeeva, J. Azimova, Kirill Skorobogatych, A. Sergeev, E. Klimov
minutes later, and after another 15 minutes the patient experienced an intense pulsating headache in the right temporal region scoring 8 on the Visual Analogue Scale (VAS) and accompanied by vomiting, photo-, phono-, and osmophobia. The pain persisted for 6-8 hours, and afterwards the patient fell asleep. The patient experienced three more similar episodes with an interval of 2 to 3 days. Two days after the last episode, the patient again woke up with an intense headache, feeling discomfort in an arm and the face. The headache score reached 10 on the VAS. Due to these complaints, the patient was admitted to a hospital.
{"title":"Syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL)","authors":"G. Tabeeva, J. Azimova, Kirill Skorobogatych, A. Sergeev, E. Klimov","doi":"10.15406/jnsk.2018.08.00299","DOIUrl":"https://doi.org/10.15406/jnsk.2018.08.00299","url":null,"abstract":"minutes later, and after another 15 minutes the patient experienced an intense pulsating headache in the right temporal region scoring 8 on the Visual Analogue Scale (VAS) and accompanied by vomiting, photo-, phono-, and osmophobia. The pain persisted for 6-8 hours, and afterwards the patient fell asleep. The patient experienced three more similar episodes with an interval of 2 to 3 days. Two days after the last episode, the patient again woke up with an intense headache, feeling discomfort in an arm and the face. The headache score reached 10 on the VAS. Due to these complaints, the patient was admitted to a hospital.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":" 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113950827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-27DOI: 10.15406/jnsk.2018.08.00298
J. Gol, Gustavo Doroszuk, Fern, O. Alvarez
Transradial approach is used routinely for performing coronary angiography in multiple centers worldwide. In our center is the first choice of approach for cerebral angiographies from two years ago. The aim of this paper is to present a case of cerebral angiography performed in a lateral decubitus position in a patient with a history of recurrent bleeding AVM at supine decubitus. Cervical and brain vessels angiography was performed in lateral decubitus position through a right radial artery puncture. This case shows the utility of this approach in cases of supine decubitus contraindication
{"title":"Cerebral Angiography in lateral decubitus","authors":"J. Gol, Gustavo Doroszuk, Fern, O. Alvarez","doi":"10.15406/jnsk.2018.08.00298","DOIUrl":"https://doi.org/10.15406/jnsk.2018.08.00298","url":null,"abstract":"Transradial approach is used routinely for performing coronary angiography in multiple centers worldwide. In our center is the first choice of approach for cerebral angiographies from two years ago. The aim of this paper is to present a case of cerebral angiography performed in a lateral decubitus position in a patient with a history of recurrent bleeding AVM at supine decubitus. Cervical and brain vessels angiography was performed in lateral decubitus position through a right radial artery puncture. This case shows the utility of this approach in cases of supine decubitus contraindication","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132875185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-25DOI: 10.15406/JNSK.2018.08.00297
Pitta Izabela Jardim Rodrigues, A. L. Rocha, Silveira Raquel Custódio, G. L. Mara, A. S. L. Gomes, Sarno Euzenir Nunes, J. M. Rodrigues
Neural damage caused by leprosy commonly presents itself as easily recognizable and treatable acute neuritis, which may occur at any time during the course of the disease.1 However, some leprosy patients present what is known as “silent neuritis”, which, due to a paucity of overt symptoms, often remains unnoticed until extensive nerve damage has taken place, particularly in the multi-bacillary (MB) leprosy forms.1–5
{"title":"Demyelination in newly-diagnosed leprosy neuropathy","authors":"Pitta Izabela Jardim Rodrigues, A. L. Rocha, Silveira Raquel Custódio, G. L. Mara, A. S. L. Gomes, Sarno Euzenir Nunes, J. M. Rodrigues","doi":"10.15406/JNSK.2018.08.00297","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00297","url":null,"abstract":"Neural damage caused by leprosy commonly presents itself as easily recognizable and treatable acute neuritis, which may occur at any time during the course of the disease.1 However, some leprosy patients present what is known as “silent neuritis”, which, due to a paucity of overt symptoms, often remains unnoticed until extensive nerve damage has taken place, particularly in the multi-bacillary (MB) leprosy forms.1–5","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133936604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-12DOI: 10.15406/jnsk.2018.8.00296
Akanksha Sharma, Marie F. Grill, S. Spritzer, A. Leis, Mark D. Anderson, P. Vig, A. Porter
Background: Acute West Nile Virus (WNV) infection can cause a spectrum of neurological disorders, including meningitis, encephalitis, and acute flaccid paralysis. Relatively little is described regarding the etiology of delayed neurological deficits or long-term sequelae in survivors of WNV neuroinvasive disease (WNND). Results: We present two cases of glial neuronal tumors in patients with severe WNND in which viral infection appears to have been a precursor to the development of aggressive brain tumors. We describe a potential mechanism where changes on a molecular signaling level by the WNV infection may result in tumor promotion. Conclusions: West Nile virus infection increases expression of pro-inflammatory and tumor-promoting proteins S100 calcium binding protein B (S100B), high-mobility group box-1 (HMGB1), and osteopontin (OPN). S100B and HMGB1 bind the receptor for advanced glycation end products (RAGE), a protein documented to be in overabundance in glial tumors. Activation of RAGE may contribute to proliferation and invasiveness of tumor cells. The presence of OPN in the tumor milieu, irrespective of its source, also leads to enhanced tumor growth and metastasis. To our knowledge, these are the first reported cases of their type. Given that WNV has the potential for altering cellular signaling at a molecular level and increasing expression of tumorigenic molecules known to be overexpressed in glial tumors, further investigations are warranted to clarify the relationship between these disease processes and potential risk for developing CNS neoplasm. In addition, there may be significant implications for brain tumor patients who develop WNV infection.
{"title":"Malignant glial neuronal tumors after west nile virus neuroinvasive disease","authors":"Akanksha Sharma, Marie F. Grill, S. Spritzer, A. Leis, Mark D. Anderson, P. Vig, A. Porter","doi":"10.15406/jnsk.2018.8.00296","DOIUrl":"https://doi.org/10.15406/jnsk.2018.8.00296","url":null,"abstract":"Background: Acute West Nile Virus (WNV) infection can cause a spectrum of neurological disorders, including meningitis, encephalitis, and acute flaccid paralysis. Relatively little is described regarding the etiology of delayed neurological deficits or long-term sequelae in survivors of WNV neuroinvasive disease (WNND). \u0000 \u0000 Results: We present two cases of glial neuronal tumors in patients with severe WNND in which viral infection appears to have been a precursor to the development of aggressive brain tumors. We describe a potential mechanism where changes on a molecular signaling level by the WNV infection may result in tumor promotion. \u0000 \u0000 Conclusions: West Nile virus infection increases expression of pro-inflammatory and tumor-promoting proteins S100 calcium binding protein B (S100B), high-mobility group box-1 (HMGB1), and osteopontin (OPN). S100B and HMGB1 bind the receptor for advanced glycation end products (RAGE), a protein documented to be in overabundance in glial tumors. Activation of RAGE may contribute to proliferation and invasiveness of tumor cells. The presence of OPN in the tumor milieu, irrespective of its source, also leads to enhanced tumor growth and metastasis. To our knowledge, these are the first reported cases of their type. Given that WNV has the potential for altering cellular signaling at a molecular level and increasing expression of tumorigenic molecules known to be overexpressed in glial tumors, further investigations are warranted to clarify the relationship between these disease processes and potential risk for developing CNS neoplasm. In addition, there may be significant implications for brain tumor patients who develop WNV infection.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"13 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125860819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-06DOI: 10.15406/JNSK.2018.08.00295
T. Wolf, Stephanie Kersten, C. Haas
The rehabilitation of severe neurological disorders belongs to the socially and economically relevant medical and therapeutic work areas. Rickels et al.1 estimate an incidence of traumatic brain injury of 332 per 100,000 inhabitants and approximately 273,000 traumatic brain injuries in Germany each year. According to the S1 guidelines of the German Society of Neurology (DGN),2 the annual incidence of acute traumatic spinal cord lesions located in industrialized countries is 10-30 cases per one million inhabitants. Men are affected 70% more often than women. The average age at accident is 40 years.3 The incidence of nontraumatic spinal cord injury (including tumors, spinal perfusion disorders, myelitis) is not known, but their frequency increases significantly with the aging of the population.
{"title":"Intensive therapeutic treatment in neuro-rehabilitation – a qualitative analysis from the therapist’s perspective","authors":"T. Wolf, Stephanie Kersten, C. Haas","doi":"10.15406/JNSK.2018.08.00295","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00295","url":null,"abstract":"The rehabilitation of severe neurological disorders belongs to the socially and economically relevant medical and therapeutic work areas. Rickels et al.1 estimate an incidence of traumatic brain injury of 332 per 100,000 inhabitants and approximately 273,000 traumatic brain injuries in Germany each year. According to the S1 guidelines of the German Society of Neurology (DGN),2 the annual incidence of acute traumatic spinal cord lesions located in industrialized countries is 10-30 cases per one million inhabitants. Men are affected 70% more often than women. The average age at accident is 40 years.3 The incidence of nontraumatic spinal cord injury (including tumors, spinal perfusion disorders, myelitis) is not known, but their frequency increases significantly with the aging of the population.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131533250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-30DOI: 10.15406/JNSK.2018.08.00292
S. Racchiusa, M. Cavallaro, M. Longo, A.A. Caragliano, Ugo Barbaro, Karol Galletta, S. Vinci, F. Granata
Spinal cord arteriovenous malformations are relatively rare pathological entities characterized by anomalous arteriovenous communication.Althoughuncommon, they are characterized by non-specific clinical presentation, ranging from mild general symptoms to even life-threatening events, such as subarachnoid or intramedullary haemorrhage, that usually results in delayed diagnosis and treatment.The purpose of this article is to briefly review the different types of spinal cord arteriovenous malformations providing an overview of the clinical, radiological and therapeutic features
{"title":"Spinal cord arteriovenous malformations: a practical guide","authors":"S. Racchiusa, M. Cavallaro, M. Longo, A.A. Caragliano, Ugo Barbaro, Karol Galletta, S. Vinci, F. Granata","doi":"10.15406/JNSK.2018.08.00292","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00292","url":null,"abstract":"Spinal cord arteriovenous malformations are relatively rare pathological entities characterized by anomalous arteriovenous communication.Althoughuncommon, they are characterized by non-specific clinical presentation, ranging from mild general symptoms to even life-threatening events, such as subarachnoid or intramedullary haemorrhage, that usually results in delayed diagnosis and treatment.The purpose of this article is to briefly review the different types of spinal cord arteriovenous malformations providing an overview of the clinical, radiological and therapeutic features","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114583438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-29DOI: 10.15406/JNSK.2018.08.00294
M. Morais, R. Mathias, B. Camporeze, S. Bologna, Vinicius Oliveira Fern, Es, C. Caggiano, P. Aguiar
The anatomy of the paraclinoid region is complex and neurosurgeons need precise microsurgical knowledge and ability to treat the aneurysms of this region. The detailed study of the clinoid region aiming to understand the anatomical landmarks and relationships between neurovascular structures (optic nerve, cavernous sinus, sella turcica) and Internal Carotid Artery (ICA) shows a crucial methodology for a safe surgical treatment of the paraclinoid aneurysms.1 This study presents a review carotid cave anatomy and aneurysms, the surgical technique to reach this area and the report of two cases.
{"title":"Case report of 2 Carotid cave aneurysms: Microsurgical anatomy and technical pitfalls","authors":"M. Morais, R. Mathias, B. Camporeze, S. Bologna, Vinicius Oliveira Fern, Es, C. Caggiano, P. Aguiar","doi":"10.15406/JNSK.2018.08.00294","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00294","url":null,"abstract":"The anatomy of the paraclinoid region is complex and neurosurgeons need precise microsurgical knowledge and ability to treat the aneurysms of this region. The detailed study of the clinoid region aiming to understand the anatomical landmarks and relationships between neurovascular structures (optic nerve, cavernous sinus, sella turcica) and Internal Carotid Artery (ICA) shows a crucial methodology for a safe surgical treatment of the paraclinoid aneurysms.1 This study presents a review carotid cave anatomy and aneurysms, the surgical technique to reach this area and the report of two cases.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133743790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-27DOI: 10.15406/JNSK.2018.08.00291
V. Kulchitsky, Alex, ra Zamaro, S. Pashkevich, Timur V. Sushko, S. Koulchitsky
Modern cell technologies quickly became the usual approach in complex treatment of patients with various diseases of the brain and spinal cord.1–4 There are systemic and local methods as the dominant ways of introducing stem cells (SC) in traumas, strokes and other destructive processes. Intravenous and intra-arterial ways of introducing SC suspension are the most popular among systemic methods.5,6 Specialists also use local methods of SC delivery to the brain, which include skull trepanation, laminectomy, and the SC introduction into cerebrospinal fluid.7,8 Additional surgical interventions (trepanation, laminectomy, suboccipital or lumbar puncture), as well as damage of significant number of SC on the way from the site of injection to the area of destruction are the disadvantages of these methods. In this regard, scientists offer alternative ways of SC introduction to the brain and spinal cord.
{"title":"Nasolacrimal way of stem cells implantation","authors":"V. Kulchitsky, Alex, ra Zamaro, S. Pashkevich, Timur V. Sushko, S. Koulchitsky","doi":"10.15406/JNSK.2018.08.00291","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00291","url":null,"abstract":"Modern cell technologies quickly became the usual approach in complex treatment of patients with various diseases of the brain and spinal cord.1–4 There are systemic and local methods as the dominant ways of introducing stem cells (SC) in traumas, strokes and other destructive processes. Intravenous and intra-arterial ways of introducing SC suspension are the most popular among systemic methods.5,6 Specialists also use local methods of SC delivery to the brain, which include skull trepanation, laminectomy, and the SC introduction into cerebrospinal fluid.7,8 Additional surgical interventions (trepanation, laminectomy, suboccipital or lumbar puncture), as well as damage of significant number of SC on the way from the site of injection to the area of destruction are the disadvantages of these methods. In this regard, scientists offer alternative ways of SC introduction to the brain and spinal cord.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114159874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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