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Inaccurate Reporting of the Effects of Laetrile: Mistreatment of Ellison, Byar and Newell (1978) in Professional Papers 对苦杏仁素影响的不准确报道:埃里森、拜尔和纽厄尔(1978)在专业论文中的不当对待
Pub Date : 2008-12-31 DOI: 10.5580/18c5
Stephen D. Krashen
There have been only two large-scale clinical studies on the impact of Laetrile (amygdalin) on cancer. In one of them, Ellison, Byar and Newell (1978) reviewed cases in which Laetrile was thought to be of help. Those who have cited this study have come to very different interpretations, however, some concluding that it showed that Laetrile was effective and some concluding that it was not. A review of Ellison et. al. shows that even a conservative interpretation of their results suggests that condemnation of Laetrile may have been premature.
关于苦杏仁苷对癌症的影响,目前只有两项大规模的临床研究。在其中一篇文章中,埃里森、拜尔和纽维尔(1978)回顾了一些认为苦杏仁素有帮助的案例。然而,那些引用这项研究的人有非常不同的解释,有些人认为它表明苦杏仁素是有效的,有些人则认为它不是。对埃里森等人的回顾表明,即使对他们的结果进行保守的解释,也表明对苦杏仁素的谴责可能为时过早。
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引用次数: 3
The Effect Of Thermal Massage On Human T-Lymphocyte And Natural Killer Cell Function 热按摩对人体t淋巴细胞和自然杀伤细胞功能的影响
Pub Date : 2007-12-31 DOI: 10.5580/317
C. So, J.V. Sarath, R. Giolli, S. Gollapudi
The purpose of this pilot study was to assess the effect of thermomechanical massage on human immune cell function. Immunological studies were performed on 10 healthy volunteers (average age: 24 years). Subjects were asked to lie on a thermomechanical massage device (TMD), for 20 minutes, twice a week, for a total of 8 weeks. Blood samples were collected before entry into the study and at the beginning of the 16th session. Peripheral blood mononuclear cells were isolated and were evaluated for immunophenotypic characteristics as well as for the functional parameters of T-lymphocytes (T cells) and natural killer (NK) cells. T cell proliferation was assessed by 3H-thymidine incorporation assay. NK cell mediated cytotoxicity was determined by a non-radioactive cytotoxicity assay kit using flow cytometry. Immunophenotyping of the peripheral blood lymphocytes showed increased percentages of T cells (CD3+), T cell subsets (CD4+ and CD8+), and NK cells (CD16+CD56+). Functional analysis revealed a significant increase in T cell proliferative response to PHA, a polyclonal T cell mitogen, and a significant increase in NK cell cytotoxicity following the use of TMD. We conclude that use of TMD twice a week may modulate immune function and may be beneficial in subjects with impaired immune function, such as aging individuals and HIV patients.
本初步研究的目的是评估热机械按摩对人体免疫细胞功能的影响。对10名健康志愿者(平均年龄24岁)进行免疫学研究。受试者被要求躺在热机械按摩装置(TMD)上20分钟,每周两次,共8周。在进入研究前和第16期开始时采集了血液样本。分离外周血单个核细胞,评估其免疫表型特征以及T淋巴细胞(T细胞)和自然杀伤细胞(NK细胞)的功能参数。采用3h -胸腺嘧啶掺入法检测T细胞增殖。NK细胞介导的细胞毒性采用非放射性细胞毒性检测试剂盒流式细胞术检测。外周血淋巴细胞的免疫表型显示T细胞(CD3+)、T细胞亚群(CD4+和CD8+)和NK细胞(CD16+CD56+)的百分比增加。功能分析显示,使用TMD后,T细胞对PHA(一种多克隆T细胞有丝分裂原)的增殖反应显著增加,NK细胞毒性显著增加。我们的结论是,每周使用两次TMD可以调节免疫功能,并且可能对免疫功能受损的受试者(如老年人和HIV患者)有益。
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引用次数: 4
Lichens- Role in Traditional Medicine and Drug Discovery 地衣-在传统医学和药物发现中的作用
Pub Date : 2007-12-31 DOI: 10.5580/3d9
S. Malhotra, R. Subban, Amritpal S. Singh
Lichens represent a unique division in the plant kingdom. They have been used in Traditional systems of medicine including Traditional Indian Medicine (TIM), Traditional Chinese Medicine (TCM), Homeopathic and Western Medical Herbals. Lichens have been used in the treatment of diverse diseases like arthritis, alopecia, constipation, kidney diseases, leprosy, pharyngitis rabies, infection, worm and infestation. The medicinal utility of lichens is regarded to presence of secondary compounds like of usnic acid and atranorin. Animal investigations on lichens have demonstrated antimicrobial, antitumor and immunomodulaor activity. One of the reasons for exploring biological compounds in lichens is the potential for medical use. However, much work remains to link medical effects with specific lichen species.
地衣代表了植物王国中一个独特的分支。它们已被用于传统医学系统,包括传统印度医学(TIM),传统中医(TCM),顺势疗法和西医草药。地衣已被用于治疗各种疾病,如关节炎、脱发、便秘、肾病、麻风病、咽炎、狂犬病、感染、蠕虫和虫害。地衣的药用价值被认为是由于地衣中含有usic酸和atanorin等次生化合物。动物实验表明地衣具有抗菌、抗肿瘤和免疫调节作用。探索地衣中生物化合物的原因之一是其潜在的医疗用途。然而,要将医疗效果与特定的地衣物种联系起来,还有很多工作要做。
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引用次数: 50
Viremedy Effects in Severe Contaminations with some Infectious Organisms in Laboratory Mice 实验小鼠受某些传染性微生物严重污染后的补救作用
Pub Date : 2007-12-31 DOI: 10.5580/326
K. Esmaeili, Z. Hassan, H. Vazini, Nima Khorramabadi, Abbas Jamali
It has been stated that Viremedy is a material including specific information, whose translation to correspondent vital information leads to rise of vital potentials fulfillment in living being (in accordance with its nature and development...). Objective: Investigation of Viremedy effects in severe contaminations with infectious organisms (as biologic stresses) in laboratory mice. Method: Control groups were given tap water not including Viremedy, and Case-1 groups were given tap water including Viremedy. Then, all mice were interaperitoneally injected by high dose of the infectious organisms. From this time, also Case-2 groups were given Viremedy. (The numbers of deaths subsequent to the contaminations in the groups were daily recorded.) Results have indicated "significant" effect of Viremedy on increase of the mice survival, in severe contaminations with Herpes simplex (type 1) "Virus" (with a direct relationship between Viremedy effect and duration of taking the remedy), Toxoplasma gondii (RH strain) "parasite", and Salmonella typhimurium "bacterium".
文章指出,Viremedy是一种包含特定信息的材料,将其翻译为相应的生命信息,可以提高生命潜力的实现(根据其性质和发展……)。目的:探讨感染生物(如生物应激)对实验小鼠严重污染的补救作用。方法:对照组给予不含Viremedy的自来水,病例-1组给予含Viremedy的自来水。然后,所有小鼠腹腔注射高剂量的感染性微生物。从此时开始,Case-2组也给予Viremedy。(每天记录各组因污染而死亡的人数。)结果表明,Viremedy对严重感染1型单纯疱疹的小鼠的存活率有“显著”的提高作用。“病毒”(Viremedy效果与服药时间有直接关系),弓形虫(RH株)“寄生虫”和鼠伤寒沙门氏菌“细菌”。
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引用次数: 1
Dietary Supplement Containing Mixture of Raw Curry, Garlic, and Ginger Powder Exerts Both Hypoglycaemic and Hypolipidaemic Effect 含有生咖喱、大蒜和姜粉混合物的膳食补充剂具有降血糖和降血脂的作用
Pub Date : 2007-12-31 DOI: 10.5580/bd4
E. Ugwuja, N. Ugwu, Augustine N. Nwibo
In a bid to determine the effect of spices mixture on some haematological and biochemical parameters, 20 normal albino rats (all male) weighing 91.9-124.84g assigned into groups I-III and controls and fed on dietary supplement containing 1%, 2%, 5% and 0%, W/W mixture of raw curry, garlic and ginger powder were investigated. Supplementation at all levels had no significant (p > 0.05) effect on body weight, haematological parameters (PCV, Hb and WBC), and serum total protein. However, the spices mixture exerted significantly (p < 0.05), both hypoglycaemic and hypolipidaemic effect at 2% w/w of the supplement beyond which there was significant increases in both mean plasma glucose and serum total cholesterol. Conclusion: While spice mixture containing raw curry, ginger and garlic powder are beneficial at culinary doses, its benefits and safety at higher doses remain unclear.
为研究香料混合物对血液学和生化指标的影响,将体重91.9 ~ 124.84g的正常白化大鼠20只(均为雄性)分为I-III组和对照组,分别饲喂含有1%、2%、5%和0% W/W的生咖喱、大蒜和姜粉混合物的饲粮。各添加水平对猪体重、血液学指标(PCV、Hb和WBC)和血清总蛋白均无显著(p > 0.05)影响。然而,在添加2% w/w时,香料混合物具有显著的降血糖和降血脂作用(p < 0.05),超过2% w/w时,平均血糖和血清总胆固醇均显著升高。结论:虽然含有生咖喱、生姜和大蒜粉的香料混合物在烹饪剂量下是有益的,但其在高剂量下的益处和安全性尚不清楚。
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引用次数: 10
Evaluation of the antiseptic properties of Cassia alata-based herbal soap 决明子基草本皂的防腐性能评价
Pub Date : 2007-12-31 DOI: 10.5580/b0e
C. O. Esimone, C. Nworu, U. Ekong, B. Okereke
In this study, we evaluated the antimicrobial potency of a herbal soap formulated with ethanol extract of Cassia alata. The herbal soap exhibited excellent antimicrobial effect in the in vitro studies as well as in the palm-washing studies on volunteers. The antimicrobial activity of the soap is predominantly against Gram-positive and opportunistic yeast. At a reduction time of 5 mins, the herbal soap recorded a significantly (P<0.05) lower mean viable microbial count of 2.12 x 104 cfu/ml (a reduction in microbial load of 94.78%) as against the 4.07 x 105 cfu/ml recorded before the application of the soap. The herbal soap formulated with Cassia alata demonstrated high potency against common pathogens of the skin and therefore a potential excipient in the production of antiseptic soaps. These findings have high medical, industrial and economic significance as extracts of Cassia alata could be harnessed in the formulation of medicated soaps.
在这项研究中,我们评估了用决明子乙醇提取物配制的草药皂的抗菌效力。该草药皂在体外实验和志愿者洗手实验中均表现出良好的抗菌效果。肥皂的抗菌活性主要是对革兰氏阳性和机会性酵母。在5分钟的还原时间内,与使用肥皂前的4.07 × 105 cfu/ml相比,草药皂的平均活菌数显著降低(P<0.05),为2.12 × 104 cfu/ml(微生物负荷减少94.78%)。用决明子配制的草药肥皂显示出对皮肤常见病原体的高效力,因此是生产抗菌肥皂的潜在辅料。这些发现具有很高的医学、工业和经济意义,因为决明子的提取物可以用于药用肥皂的配方中。
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引用次数: 38
Does Massage Therapy affect Brain Metabolites 按摩疗法会影响大脑代谢物吗
Pub Date : 2007-12-31 DOI: 10.5580/1f7f
N. Binesh, R. Cohen, F. Moser, M. Maya, B. Pressman, M. Rapaport
This performed study was to examine changes in brain metabolites following Light Touch (simulated massage) and Swedish massage (deep tissue massage) detected by MR Spectroscopy. The results showed no significant alteration in brain metabolites before and after Light Touch or Swedish massage.
本研究通过磁共振光谱检测轻触(模拟按摩)和瑞典式按摩(深层组织按摩)后脑代谢物的变化。结果显示轻触或瑞典式按摩前后脑代谢物无明显变化。
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引用次数: 2
HPLC Analysis of the Phenolic Profiles in Different Parts of Chilli (Capsicum annum) and Okra (Abelmoschus esculentus L.) Moench 辣椒(Capsicum annum)和秋葵(Abelmoschus esculentus L.)不同部位酚类成分HPLC分析Moench
Pub Date : 2007-12-31 DOI: 10.5580/103d
U. P. Singh, A. Suman, M. Sharma, Jaya Singh, Amitabh Singh, S. Maurya
The nature of phenolic acids in the two important vegetable crops chilli (Capsicum annum, Family Solanaceae) and okra (Abelmoschus esculentus L. Family Malvaceae) was investigated and their medicinal significance was discussed. Presence of tannic, gallic, caffeic, vanillic, ferulic, chlorogenic and cinnamic acids was recorded in different parts of the plant and seeds of various varieties. Gallic acid was found to be the major constituent in almost all the plant parts of chilli and okra. Concentration of tannic, ferulic, chlorogenic and cinnamic acids varied significantly in seeds of okra varieties, namely, BO2, VRO5, IIVRO10 and Prabhani Kranti. Presence of caffeic acid could only be traced in different varieties of chilly while vannillc acid was found only in the fruits of sweet pepper.
研究了两种重要蔬菜作物辣椒(辣椒科,茄科)和秋葵(秋葵科,Abelmoschus esculentus L.)中酚酸的性质,并讨论了它们的药用意义。单宁酸、没食子酸、咖啡酸、香草酸、阿魏酸、绿原酸和肉桂酸存在于植物的不同部位和不同品种的种子中。没食子酸被发现是几乎所有辣椒和秋葵植物部分的主要成分。不同秋葵品种BO2、VRO5、IIVRO10和Prabhani Kranti种子中单宁酸、阿魏酸、绿原酸和肉桂酸的浓度差异显著。咖啡酸只存在于不同品种的辣椒中,而香草酸只存在于甜椒的果实中。
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引用次数: 10
Indian Herbal Drug for General Healthcare: An Overview 印度草药一般医疗保健:概述
Pub Date : 2007-12-31 DOI: 10.5580/1c51
M. Pandey, S. Rastogi, A. Rawat
The medicinal plants are important therapeutic aids for alleviating various ailments of humankind. In the recent past there has been a tremendous increase in the use of plant-based health products in developing as well as developed countries resulting in an exponential growth of herbal products globally. An upward trend has been observed in the research on herbals. Export–Import Bank reports reveal that the global trade of plant-derived and plant originated products is around US $60 billion. Herbal medicines have a strong traditional or conceptual base and the potential to be useful as drugs in terms of safety and effectiveness leads for treating different diseases. India, with its mega-biodiversity and knowledge-rich ancient traditional systems of medicine viz. Ayurveda, Siddha, Unani, Amchi and local health traditions, provides a strong base for the utilization of a large number of plants in general healthcare and alleviation of common ailments of the people. A number of Indian medicinal plants are used as rejuvenators as well as for treating various disease conditions. They may be tonics, antimalarials, antipyretics, aphrodisiacs, expectorants, hepatoprotectives, antirheumatics, diuretics etc. However, proper methodologies for the research and development are the need of the day for tapping the full therapeutic potentials of plants. In the present article an endeavor has been made to present an overview of the Indian medicinal plants used for general healthcare. Since the different systems of medicine practised in India, viz, Ayurveda, Siddha, Unani, Amchi and local health traditions, utilize a large number of plants that are commonly used as tonics, antimalarials, antipyretics, aphrodisiacs, expectorants, hepatoprotectives, antirheumatics, diuretics etc, an attempt has also been made to enumerates some of these plants/ drugs used for the alleviation of some common ailments with special emphasis on Rasayana drugs. 1. HERBAL DRUGS-CURRENT SCENARIO Use of herbal medicines is wide spread in developing as well as developed countries. The use of plant-based health products was also increased in other European countries [1]. Export–Import Bank reports reveal that the global trade of plant-derived and plant originated products is around US $60 billion (with growth of 7% per annum) where India holds stake of US $1 billion [2,3] which is expected to reach 3 trillion US$ by the end of 2015. World Health Organization (WHO) has made an attempt to identify all medicinal plants used globally and listed more than 20,000 species. NAPRALERT database documents ethnomedicinal uses alone for 9200 of 33000 species of monocots, dicots, gymnosperms, pteridophytes, bryophytes and lichens, which would suggest that 28 % of plants on earth have been used ethnomedicinally [4]. India is also considered as one of the potential exporting countries of medicinal plants. India has 2.4% of world's area with 8% of global biodiversity. It is one of the 12 megadiversity hot-spot r
药用植物是缓解人类各种疾病的重要治疗手段。最近,在发展中国家和发达国家,植物性保健产品的使用急剧增加,导致全球草药产品呈指数级增长。草药研究呈上升趋势。进出口银行的报告显示,植物衍生和植物源产品的全球贸易额约为600亿美元。草药具有强大的传统或概念基础,并且在治疗不同疾病的安全性和有效性方面可能成为有用的药物。印度拥有丰富的生物多样性和知识丰富的古老传统医学体系,如阿育吠陀、悉达、乌纳尼、阿姆奇和当地的健康传统,为在一般医疗保健中利用大量植物和减轻人们的常见病提供了坚实的基础。许多印度药用植物被用作恢复活力剂以及治疗各种疾病。它们可能是补药、抗疟药、解热药、壮阳药、祛痰药、护肝药、抗风湿药、利尿剂等。然而,为了充分挖掘植物的治疗潜力,需要适当的研究和开发方法。在本文中,已经作出了一项努力,以介绍用于一般保健的印度药用植物的概述。由于印度不同的医学体系,即阿育吠陀、悉达陀、乌纳尼、阿姆奇和当地的保健传统,使用了大量的植物,这些植物通常被用作补药、抗疟药、解热药、壮阳药、祛痰药、肝保护药、抗风湿药、利尿剂等,因此也试图列举一些用于减轻一些常见疾病的植物/药物,特别强调了Rasayana药物。1. 草药-目前的情况草药的使用在发展中国家和发达国家都很广泛。在其他欧洲国家,植物性保健产品的使用也有所增加[1]。进出口银行的报告显示,植物衍生和植物源产品的全球贸易约为600亿美元(每年增长7%),其中印度持有10亿美元的股份[2,3],预计到2015年底将达到3万亿美元。世界卫生组织(世卫组织)试图确定全球使用的所有药用植物,并列出了2万多种。NAPRALERT数据库记录了单子叶、双子叶、裸子植物、蕨类植物、苔藓植物和地衣等33000种植物中9200种的民族药用用途,这表明地球上28%的植物已被用于民族药用[4]。印度也被认为是药用植物的潜在出口国之一。印度占世界面积的2.4%,生物多样性占全球的8%。它是世界上12个超级多样性热点地区之一,其他国家有巴西、哥伦比亚、中国、南非、墨西哥、委内瑞拉、印度尼西亚、厄瓜多尔、秘鲁、美国和玻利维亚。在全国范围内,印度的森林估计蕴藏着印度90%的药用植物多样性。印度只有大约10%的已知药用植物局限于非森林生境。根据一份报告[5],在印度发现的所有植物中有五分之一用于药用。图1显示了印度前20大药用植物的国内需求量估算[6]。利用植物的治疗特性是所有传统做法的一个组成部分。早在史前时代,各大洲的人们就一直使用数以百计的本土植物来治疗各种疾病。有证据表明尼安德特人生活在6万年前[7]。这些植物在世界各地的民族医药中仍被广泛使用。印度草药一般医疗保健:概述
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引用次数: 92
Critical Study of Aloe ferox in view of Ayurveda 从阿育吠陀的角度对芦荟素的批判性研究
Pub Date : 2007-12-31 DOI: 10.5580/1f4
Sharduli Rajiv Terwadkar Ayurvedavaridhi, P.H.Kulkarn Ayurvedavaridhi
South Africa & India have rich heritage of ancient wisdom and their Traditional Medicinal Systems are part of it. Aloe ferox is compared with Aloe vera on the basis of Ayurvedic principles & other theories. This is theoretical research & can lead to many interesting researches. On the basis of this study, dried exudate of Kumari (Aloe vera) can be used which is not commonly seen in practice. As Kumari (Aloe vera) shows similarity to Aloe ferox used in Traditional South African Medicine, we can use them as substitute to eachother. This study throws light on many new uses of Kumari & also leads to researches in many fields like Ayurveda, Pharmacology, Ethnobotany, Ethnomedicine etc. This study proves that we can compare plants of same family & genus occurring in different countries with the help of Ayurvedic principles explained in texts of DravyaGunaVidnyan.
南非和印度拥有丰富的古代智慧遗产,他们的传统医疗系统是其中的一部分。芦荟素与芦荟在阿育吠陀原理和其他理论的基础上进行比较。这是理论研究,可以导致许多有趣的研究。在本研究的基础上,干燥的库玛利(芦荟)渗出液可以使用,这在实践中并不常见。由于Kumari(芦荟)与南非传统医学中使用的芦荟有相似之处,我们可以将它们相互替代。这项研究揭示了库玛丽的许多新用途,也导致了许多领域的研究,如阿育吠陀、药理学、民族植物学、民族医学等。这项研究证明,我们可以在DravyaGunaVidnyan文本中解释的阿育吠陀原理的帮助下,比较发生在不同国家的同一家族和属的植物。
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引用次数: 2
期刊
The Internet Journal of Alternative Medicine
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