Purpose: In the study, the therapeutic effects of early and long-term transcranial direct current stimulation (tDCS) in Parkinson's disease (PD) rats with 6-hydroxydopamine (6-OHDA) lesions of tDCS were investigated.
Materials and Methods: After early and prolonged tDCS administration in PD animals (starting 24 hours after PD lesion, 1000 mA anodal tDCS, 30 min/day, 13 days), the effects of tDCS on motor and cognitive function behaviors and glutamatergic neuron excitotoxicity were determined by Ca2+, glutamate, and NMDAR1 levels.
Results: We found that the 13-day tDCS intervention significantly reduced 6-OHDA-induced motor deficits in locomotor activity, learning, and memory-like behavior. Biochemically, we showed that it also reduces Ca2+, glutamate, and NMDAR1 levels, which cause hippocampal neuronal damage.
Conclusion: These results suggest that early and long-term tDCS may exert neuroprotective effects and reduce the exacerbation of motor and cognitive impairments in a rat model of 6-OHDA-induced PD. However, it also shows that tDCS has an effect on the glutamatergic pathway in PD and prevents neuronal excitotoxicity. Furthermore, this preclinical model may increase the potential use of therapeutic tDCS and serve as a translation platform to further define the therapeutic mechanism of tDCS for PD or other disorders.
{"title":"Transcranial direct current stimulation ameliorates motor and cognitive functions by regulating neuronal excitotoxicity in experimental Parkinson’s disease model","authors":"Güven AKÇAY, Serhan TAMERER","doi":"10.17826/cumj.1322361","DOIUrl":"https://doi.org/10.17826/cumj.1322361","url":null,"abstract":"Purpose: In the study, the therapeutic effects of early and long-term transcranial direct current stimulation (tDCS) in Parkinson's disease (PD) rats with 6-hydroxydopamine (6-OHDA) lesions of tDCS were investigated.
 Materials and Methods: After early and prolonged tDCS administration in PD animals (starting 24 hours after PD lesion, 1000 mA anodal tDCS, 30 min/day, 13 days), the effects of tDCS on motor and cognitive function behaviors and glutamatergic neuron excitotoxicity were determined by Ca2+, glutamate, and NMDAR1 levels. 
 Results: We found that the 13-day tDCS intervention significantly reduced 6-OHDA-induced motor deficits in locomotor activity, learning, and memory-like behavior. Biochemically, we showed that it also reduces Ca2+, glutamate, and NMDAR1 levels, which cause hippocampal neuronal damage.
 Conclusion: These results suggest that early and long-term tDCS may exert neuroprotective effects and reduce the exacerbation of motor and cognitive impairments in a rat model of 6-OHDA-induced PD. However, it also shows that tDCS has an effect on the glutamatergic pathway in PD and prevents neuronal excitotoxicity. Furthermore, this preclinical model may increase the potential use of therapeutic tDCS and serve as a translation platform to further define the therapeutic mechanism of tDCS for PD or other disorders.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The aim of this study was to evaluate histone deacetylase inhibitory and antioxidant activities of some ethanolic plant extracts.
Materials and Methods: In this study, the inhibitory effects of ethyl alcohol extracts prepared from various plants and some chemical compounds on histone deacetylase activity were investigated. In addition, the antioxidant activity of plant-derived active substances, which have had an important value in alternative medicine in recent years, has been determined to replace chemicals.
Results: All the plant extracts and chemical substances used in the study showed histone deacetylase inhibitory effect (with IC50 range of 0.000078-319.0 µg/mL) and antioxidant activity. The results indicated that the percentage of histone deacetylase inhibition and antioxidant activities increased with increasing concentrations of the plant extracts and chemical compounds.
Conclusion: These plant extracts which are potential sources of histone deacetylase inhibitors may be appropriately used as an alternative support to drug treatment rather than the use of toxic chemicals.
{"title":"Bazı etanolik bitki ekstrelerinin histon deasetilaz inhibitör ve antioksidan aktiviteleri: Kanser için yeni bir terapötik yaklaşım","authors":"Eda DAĞSUYU, Refiye YANARDAĞ","doi":"10.17826/cumj.1316664","DOIUrl":"https://doi.org/10.17826/cumj.1316664","url":null,"abstract":"Purpose: The aim of this study was to evaluate histone deacetylase inhibitory and antioxidant activities of some ethanolic plant extracts. 
 Materials and Methods: In this study, the inhibitory effects of ethyl alcohol extracts prepared from various plants and some chemical compounds on histone deacetylase activity were investigated. In addition, the antioxidant activity of plant-derived active substances, which have had an important value in alternative medicine in recent years, has been determined to replace chemicals.
 Results: All the plant extracts and chemical substances used in the study showed histone deacetylase inhibitory effect (with IC50 range of 0.000078-319.0 µg/mL) and antioxidant activity. The results indicated that the percentage of histone deacetylase inhibition and antioxidant activities increased with increasing concentrations of the plant extracts and chemical compounds. 
 Conclusion: These plant extracts which are potential sources of histone deacetylase inhibitors may be appropriately used as an alternative support to drug treatment rather than the use of toxic chemicals.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The aim of this study is to retrospectively evaluate the effects of body (abdominal) and auricular acupuncture combination therapy on anthropometric measurements and blood parameters in obesity control.
Materials and Methods: This study is a descriptive, cross-sectional and retrospective study. This study was carried out by retrospectively scanning the patient files of the patients who applied to the obesity center between 01.05.2019 and 15.02.2020 and wanted to have acupuncture.
Results: There are 10 points selected: Shenmen (HT7, spirit gate), point zero, small intestine, large intestine, stomach, esophagus, mouth, appetite control (hunger), antidepressant and spleen point. The abdominal acupuncture points applied to the patients for the treatment of obesity are shown in this study. There are 6 points selected: ST 25, ST 26, REN 12 (CV12), REN 10 (CV10), REN 6 (CV6), REN 4 (CV4). The results show that combined ear and abdominal acupuncture resulted in significant weight loss in all participants in the acupuncture group. The mean high-density lipoprotein cholesterol (HDL-C) mean scores of the patients who underwent acupuncture were significantly higher whereas the mean low-density lipoprotein cholesterol (LDL-C) scores was significantly lower than the patients who did not receive acupuncture.
Conclusion: Ear and abdominal acupuncture applications applied for three months for weight loss in obese individuals provided significant weight loss, along with a significant decrease in waist/hip ratio and improvement in all other blood parameters.
{"title":"Vücut ve kulak akupunkturu kombinasyon tedavisinin obezite kontrolündeki etkilerinin değerlendirilmesi: retrospektif bir çalışma","authors":"Duygu İlke YILDIRIM","doi":"10.17826/cumj.1314635","DOIUrl":"https://doi.org/10.17826/cumj.1314635","url":null,"abstract":"Purpose: The aim of this study is to retrospectively evaluate the effects of body (abdominal) and auricular acupuncture combination therapy on anthropometric measurements and blood parameters in obesity control.
 Materials and Methods: This study is a descriptive, cross-sectional and retrospective study. This study was carried out by retrospectively scanning the patient files of the patients who applied to the obesity center between 01.05.2019 and 15.02.2020 and wanted to have acupuncture.
 Results: There are 10 points selected: Shenmen (HT7, spirit gate), point zero, small intestine, large intestine, stomach, esophagus, mouth, appetite control (hunger), antidepressant and spleen point. The abdominal acupuncture points applied to the patients for the treatment of obesity are shown in this study. There are 6 points selected: ST 25, ST 26, REN 12 (CV12), REN 10 (CV10), REN 6 (CV6), REN 4 (CV4). The results show that combined ear and abdominal acupuncture resulted in significant weight loss in all participants in the acupuncture group. The mean high-density lipoprotein cholesterol (HDL-C) mean scores of the patients who underwent acupuncture were significantly higher whereas the mean low-density lipoprotein cholesterol (LDL-C) scores was significantly lower than the patients who did not receive acupuncture.
 Conclusion: Ear and abdominal acupuncture applications applied for three months for weight loss in obese individuals provided significant weight loss, along with a significant decrease in waist/hip ratio and improvement in all other blood parameters.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The aim of this study was to determine the drug-drug interactions that are frequently encountered in critically ill patients and the factors that predict these interactions.
Materials and Methods: All patients who were admitted to the pediatric intensive care unit (13 bed) of a university hospital and used more than one drug in their treatment were included in this prospective and cross-sectional study. Patients' demographics, laboratory findings, and medications included in their treatment were evaluated daily by a clinical pharmacist. The UpToDate® database was used to detect potential drug interactions.
Results: During the study, 797 potential drug-drug interactions were detected in 55 (83.33%) of 66 patients followed. All these interactions were evaluated by the clinical pharmacist and 114 recommendations were made to the physicians following the treatment regarding these potential interactions. Eighty-five (74.56%) of these recommendations were accepted by physicians. Within the scope of the study, each patient was followed up for a median of 9 (2-63) days, and the median value of potential drug interactions detected during this period was calculated as 7 (1-89).
Conclusion: The existence of pDDIs was significantly associated with the number of prescribed medications. Exposure to pDDIs is frequent in critically ill pediatric patients and related to the number of medications. Daily and close cooperation between clinicians and clinical pharmacists is recommended to prevent harmful outcomes of DDIs. In order to minimize this risk, it is recommended to avoid polypharmacy as much as possible and to offer alternatives to inducer and inhibitor drugs in treatment.
{"title":"Evaluation of drug-drug interactions in critically ill pediatric patients","authors":"Nursel SURMELİOGLU, Hatice Yağmur SOYSAL, İkbal TÜRKER, Faruk EKİNCİ, Ozden OZGUR HOROZ, Dinçer YILDIZDAŞ","doi":"10.17826/cumj.1341543","DOIUrl":"https://doi.org/10.17826/cumj.1341543","url":null,"abstract":"Purpose: The aim of this study was to determine the drug-drug interactions that are frequently encountered in critically ill patients and the factors that predict these interactions. 
 Materials and Methods: All patients who were admitted to the pediatric intensive care unit (13 bed) of a university hospital and used more than one drug in their treatment were included in this prospective and cross-sectional study. Patients' demographics, laboratory findings, and medications included in their treatment were evaluated daily by a clinical pharmacist. The UpToDate® database was used to detect potential drug interactions. 
 Results: During the study, 797 potential drug-drug interactions were detected in 55 (83.33%) of 66 patients followed. All these interactions were evaluated by the clinical pharmacist and 114 recommendations were made to the physicians following the treatment regarding these potential interactions. Eighty-five (74.56%) of these recommendations were accepted by physicians. Within the scope of the study, each patient was followed up for a median of 9 (2-63) days, and the median value of potential drug interactions detected during this period was calculated as 7 (1-89). 
 Conclusion: The existence of pDDIs was significantly associated with the number of prescribed medications. Exposure to pDDIs is frequent in critically ill pediatric patients and related to the number of medications. Daily and close cooperation between clinicians and clinical pharmacists is recommended to prevent harmful outcomes of DDIs. In order to minimize this risk, it is recommended to avoid polypharmacy as much as possible and to offer alternatives to inducer and inhibitor drugs in treatment.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The aim of this study was to evaluate the common interventions performed by neurosurgery and otolaryngology in dural invasion in frontal sinus related pathologies.
Materials and Methods: A comprehensive study involving 45 patients who underwent surgical interventions for frontal sinus-associated pathologies between January 2018 and July 2023 was conducted collaboratively by otorhinolaryngology and neurosurgery departments. Patient data, including demographics, pathology types, and surgical approaches, were collected from medical records, surgical reports, imaging studies, and videos. Interdisciplinary surgical teams executed tailored interventions with documented techniques.
Results: Among 45 patients, 31 were female (68.8%) with a mean age of 44. Posterior wall defects were detected in 13 (28.8%) patients, and intervention was necessary for only 8 of them. Among the 8 (17.7%) patients with identified dural invasion, pathological dural tissue was excised, and duraplasty was performed in 5 (11.1%) cases. There were no neurological complications observed in patients during the postoperative period.
Conclusion: Despite limitations, the findings contribute to evolving knowledge and highlight the need for prospective studies to optimize patient care strategies.
{"title":"Assessment of dural invasion in complex cases operated on by collaborative efforts of neurosurgery and otolaryngology for pathologies associated with the frontal sinus","authors":"Tolga GEDİZ, Özer GÜR","doi":"10.17826/cumj.1351185","DOIUrl":"https://doi.org/10.17826/cumj.1351185","url":null,"abstract":"Purpose: The aim of this study was to evaluate the common interventions performed by neurosurgery and otolaryngology in dural invasion in frontal sinus related pathologies.
 Materials and Methods: A comprehensive study involving 45 patients who underwent surgical interventions for frontal sinus-associated pathologies between January 2018 and July 2023 was conducted collaboratively by otorhinolaryngology and neurosurgery departments. Patient data, including demographics, pathology types, and surgical approaches, were collected from medical records, surgical reports, imaging studies, and videos. Interdisciplinary surgical teams executed tailored interventions with documented techniques. 
 Results: Among 45 patients, 31 were female (68.8%) with a mean age of 44. Posterior wall defects were detected in 13 (28.8%) patients, and intervention was necessary for only 8 of them. Among the 8 (17.7%) patients with identified dural invasion, pathological dural tissue was excised, and duraplasty was performed in 5 (11.1%) cases. There were no neurological complications observed in patients during the postoperative period.
 Conclusion: Despite limitations, the findings contribute to evolving knowledge and highlight the need for prospective studies to optimize patient care strategies.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meltem GÜMÜŞ, Alaaddin YORULMAZ, Hakan CANDAN, Anna Carina ERGANİ, Reyhan GÜMÜŞTEKİN, Fuat BUĞRUL, Hüsamettin VATANSEV, Halil Haldun EMİROĞLU
Purpose: The objectives of the present study were to develop biochemical indices as a more practical way for the early diagnosis of cases with suspected metabolic dysfunction-assosiated steatotic liver disease (MASLD) and to develop easy biomarkers to enable clinicians to recognize MASLD in obese children.
Materials and Methods: A total of 90 patients who had MASLD and 70 healthy volunteering children between the ages of 6-18 who were diagnosed with reference to the ESPGHAN 2012 Guideline between January 2020 and March 2023 were included. Age, gender, Anthropometric measurements and biochemical analysis were determined. Some Biochemical ratios such as HOMA-IR, HOMA-β, FGIR, QUICKI, AIP etc were calculated.
Results: There were 40 (44.4%) girls and 50 (55.6%) boys in the patient group.A positive correlation was found between AST, GGT, TSH, LDL, TG, total cholesterol, HDL, FAS, insulin, HOMA-IR, HOMA-β, QUICKI score, FGIR, MHR, LHR, LKR, THR ALT/AST ratios and Systemic Immun Inflammatory Index values in the analysis. The ROC analysis results of the HOMA-IR value was taken as 2.94, the specificity of the diagnostic value was found to be 52.20% and the sensitivity was 80.0%.
Conclusion: MASLD has an increasing trend today.Based on the design of the present study, it was concluded that almost all of the biochemical parameters and biomarkers obtained are among the most accurate and useful indices to determine MASLD and IR and predict complications.
{"title":"Insulin resistance and cardiovascular risk factors in childhood metabolic dysfunction-associated steatotic liver disease","authors":"Meltem GÜMÜŞ, Alaaddin YORULMAZ, Hakan CANDAN, Anna Carina ERGANİ, Reyhan GÜMÜŞTEKİN, Fuat BUĞRUL, Hüsamettin VATANSEV, Halil Haldun EMİROĞLU","doi":"10.17826/cumj.1326206","DOIUrl":"https://doi.org/10.17826/cumj.1326206","url":null,"abstract":"Purpose: The objectives of the present study were to develop biochemical indices as a more practical way for the early diagnosis of cases with suspected metabolic dysfunction-assosiated steatotic liver disease (MASLD) and to develop easy biomarkers to enable clinicians to recognize MASLD in obese children. 
 Materials and Methods: A total of 90 patients who had MASLD and 70 healthy volunteering children between the ages of 6-18 who were diagnosed with reference to the ESPGHAN 2012 Guideline between January 2020 and March 2023 were included. Age, gender, Anthropometric measurements and biochemical analysis were determined. Some Biochemical ratios such as HOMA-IR, HOMA-β, FGIR, QUICKI, AIP etc were calculated.
 Results: There were 40 (44.4%) girls and 50 (55.6%) boys in the patient group.A positive correlation was found between AST, GGT, TSH, LDL, TG, total cholesterol, HDL, FAS, insulin, HOMA-IR, HOMA-β, QUICKI score, FGIR, MHR, LHR, LKR, THR ALT/AST ratios and Systemic Immun Inflammatory Index values in the analysis. The ROC analysis results of the HOMA-IR value was taken as 2.94, the specificity of the diagnostic value was found to be 52.20% and the sensitivity was 80.0%.
 Conclusion: MASLD has an increasing trend today.Based on the design of the present study, it was concluded that almost all of the biochemical parameters and biomarkers obtained are among the most accurate and useful indices to determine MASLD and IR and predict complications.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: This study was conducted to investigate the effects of postoperative lateral positioning on the patients’ outcomes with subarachnoid hemorrhage.
Materials and Methods: This study, which is a randomized controlled intervention study, was conducted with 42 (experimental group: 21, control group: 21) patients who underwent subarachnoid hemorrhage surgery in the neurosurgery intensive care unit of a university hospital and met the sampling criteria. In the study, "Patient Descriptive Information Form" and "Patient Results Form" were used as data collection tools. A total of 42 patients operated on for subarachnoid hemorrhage were included in the study. While the patients in the intervention group were placed in the left lateral, right lateral, and semi-fowler position (30 degrees) every 2 to 4 hours for the first 72 hours, those in the control group were routinely placed in the semi-fowler position (20 to 45 degrees).
Results: The power of hydrogen value and partial oxygen pressure and arterial oxygen saturation at the 48th hour in the intervention group were statistically significantly higher than the control group at the 72nd hour. In the intervention group, a slight decrease was observed only in the heart rate at 72 hours, which was near normal.
Conclusion: Lateral and semi-fowler positions with a 2 to 4 hour interval contributed to improved oxygenation and prevented secondary complications of subarachnoid hemorrhage.
{"title":"Effects of postoperative lateral positioning on outcomes of patients with subarachnoid hemorrhage","authors":"Ceylan KİŞİAL, Sevilay ERDEN","doi":"10.17826/cumj.1277791","DOIUrl":"https://doi.org/10.17826/cumj.1277791","url":null,"abstract":"Purpose: This study was conducted to investigate the effects of postoperative lateral positioning on the patients’ outcomes with subarachnoid hemorrhage. 
 Materials and Methods: This study, which is a randomized controlled intervention study, was conducted with 42 (experimental group: 21, control group: 21) patients who underwent subarachnoid hemorrhage surgery in the neurosurgery intensive care unit of a university hospital and met the sampling criteria. In the study, \"Patient Descriptive Information Form\" and \"Patient Results Form\" were used as data collection tools. A total of 42 patients operated on for subarachnoid hemorrhage were included in the study. While the patients in the intervention group were placed in the left lateral, right lateral, and semi-fowler position (30 degrees) every 2 to 4 hours for the first 72 hours, those in the control group were routinely placed in the semi-fowler position (20 to 45 degrees). 
 Results: The power of hydrogen value and partial oxygen pressure and arterial oxygen saturation at the 48th hour in the intervention group were statistically significantly higher than the control group at the 72nd hour. In the intervention group, a slight decrease was observed only in the heart rate at 72 hours, which was near normal.
 Conclusion: Lateral and semi-fowler positions with a 2 to 4 hour interval contributed to improved oxygenation and prevented secondary complications of subarachnoid hemorrhage.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The goal of this study was to evaluate the expression of transient receptor potential vanilloid 6 (TRPV6) and plasma membrane Ca2+ ATPase 1 (PMCA1) in the endometrium of infertile women with unexplained infertility (UI) and endometriosis (E), and to compare the findings to healthy fertile women.
Materials and Methods: Endometrial expression of TRPV6 and PMCA1 proteins was evaluated during the mid-secretory phase using the immunohistochemical method, and mRNA levels were measured by real-time PCR. Calcium concentrations were determined using Inductively coupled plasma-mass spectrometry (ICP-MS).
Results: TRPV6 and PMCA1 protein expression were significantly increased in both luminal and glandular epithelium of UI or E groups compared to the control group. TRPV6 mRNA expression levels were significantly lower in the UI group (0.525 ± 0.087) compared to the control group (0.809 ± 0.073). There was no significant difference in PMCA1 mRNA expression levels between the groups. Calcium concentration was significantly higher in women with UI (median (Q1-Q3): 50.57 [40.67-51.37], compared to the control group (median (Q1-Q3): 24.29 [20.11-25.55]).
Conclusion: The present findings demonstrate altered expressions of TRPV6 and PMCA1 mRNA and protein, along with differences in calcium concentration among patients, especially those with the UI during the window of implantation. These differences might potentially be considered as one of the underlying causes of infertility. Further studies are needed to elucidate the functional roles of these channels and to develop new strategies for pharmaceutical intervention in the treatment of infertility.
{"title":"The expression of TRPV6 and PMCA1 in the mid-secretory endometrium of infertile patients with unexplained infertility and endometriosis","authors":"Tuba OZCAN METİN, Nafiye YILMAZ, Banu YILMAZ, Şakir Necat YILMAZ, Mehmet Emin ERDAL, İlay BURAN, Gülhan TEMEL, Adem DOĞANER","doi":"10.17826/cumj.1310778","DOIUrl":"https://doi.org/10.17826/cumj.1310778","url":null,"abstract":"Purpose: The goal of this study was to evaluate the expression of transient receptor potential vanilloid 6 (TRPV6) and plasma membrane Ca2+ ATPase 1 (PMCA1) in the endometrium of infertile women with unexplained infertility (UI) and endometriosis (E), and to compare the findings to healthy fertile women.
 Materials and Methods: Endometrial expression of TRPV6 and PMCA1 proteins was evaluated during the mid-secretory phase using the immunohistochemical method, and mRNA levels were measured by real-time PCR. Calcium concentrations were determined using Inductively coupled plasma-mass spectrometry (ICP-MS). 
 Results: TRPV6 and PMCA1 protein expression were significantly increased in both luminal and glandular epithelium of UI or E groups compared to the control group. TRPV6 mRNA expression levels were significantly lower in the UI group (0.525 ± 0.087) compared to the control group (0.809 ± 0.073). There was no significant difference in PMCA1 mRNA expression levels between the groups. Calcium concentration was significantly higher in women with UI (median (Q1-Q3): 50.57 [40.67-51.37], compared to the control group (median (Q1-Q3): 24.29 [20.11-25.55]).
 Conclusion: The present findings demonstrate altered expressions of TRPV6 and PMCA1 mRNA and protein, along with differences in calcium concentration among patients, especially those with the UI during the window of implantation. These differences might potentially be considered as one of the underlying causes of infertility. Further studies are needed to elucidate the functional roles of these channels and to develop new strategies for pharmaceutical intervention in the treatment of infertility.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali ORGUN, Niyazi TOKEL, İlkay ERDOĞAN, Birgül VARAN, Murat ÖZKAN, Mehmet Sait AŞLAMACI
Purpose: In this retrospective study, pediatric patients who underwent surgery for large ventricular septal defect (VSD) with severe pulmonary arterial hypertension (PAH) were evaluated in detail in terms of clinical characteristics, and long-term results, and reinterpreted with the current surgical criteria.
Materials and Methods: Twenty-four patients who underwent surgery for large VSD due to PAH between 1994 and 2005 were included in the study. The patients were divided into two groups according to their pulmonary vascular resistance index (PVRI) and compared (group 1 with PVRI
{"title":"Surgical outcomes and long-term follow-up of patients with large ventricular septal defects with severe pulmonary arterial hypertension: single-center experience","authors":"Ali ORGUN, Niyazi TOKEL, İlkay ERDOĞAN, Birgül VARAN, Murat ÖZKAN, Mehmet Sait AŞLAMACI","doi":"10.17826/cumj.1335119","DOIUrl":"https://doi.org/10.17826/cumj.1335119","url":null,"abstract":"Purpose: In this retrospective study, pediatric patients who underwent surgery for large ventricular septal defect (VSD) with severe pulmonary arterial hypertension (PAH) were evaluated in detail in terms of clinical characteristics, and long-term results, and reinterpreted with the current surgical criteria.
 Materials and Methods: Twenty-four patients who underwent surgery for large VSD due to PAH between 1994 and 2005 were included in the study. The patients were divided into two groups according to their pulmonary vascular resistance index (PVRI) and compared (group 1 with PVRI","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa KALE, Saadet SAĞTAŞ, Yonca BİR, Ayşe Şenay KOÇ, Murat KOÇ
Purpose: This research aims to determine the effect of body satisfaction on impulse purchase behaviour and to detect differences in body satisfaction and impulse buying behaviour according to demographic factors. Materials and Method: The data were collected from 346 students educating different departments at a foundation university in Mersin. The survey method was used and analyzed with path analysis, independent samples t-test, and one-way ANOVA. Results: The positive effect of body satisfaction was observed on impulse buying behaviour. And differences in body satisfaction and impulse buying behaviour were investigated according to gender and monthly budget. Body satisfaction differs by gender, while impulse buying behaviour to a monthly budget. Conclusion: Purchase behaviour tends to increase when body satisfaction increases. Body satisfaction is higher among male students, and the purchase behaviour of students with a high monthly budget is more.
{"title":"Effect of body satisfaction on online impulse purchase behavior of young people","authors":"Mustafa KALE, Saadet SAĞTAŞ, Yonca BİR, Ayşe Şenay KOÇ, Murat KOÇ","doi":"10.17826/cumj.1336920","DOIUrl":"https://doi.org/10.17826/cumj.1336920","url":null,"abstract":"Purpose: This research aims to determine the effect of body satisfaction on impulse purchase behaviour and to detect differences in body satisfaction and impulse buying behaviour according to demographic factors. Materials and Method: The data were collected from 346 students educating different departments at a foundation university in Mersin. The survey method was used and analyzed with path analysis, independent samples t-test, and one-way ANOVA. Results: The positive effect of body satisfaction was observed on impulse buying behaviour. And differences in body satisfaction and impulse buying behaviour were investigated according to gender and monthly budget. Body satisfaction differs by gender, while impulse buying behaviour to a monthly budget. Conclusion: Purchase behaviour tends to increase when body satisfaction increases. Body satisfaction is higher among male students, and the purchase behaviour of students with a high monthly budget is more.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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