Critical reviews in food science and nutrition最新文献

The early intrauterine environment of mothers during pregnancy significantly affects the metabolic health of their offspring. Existing studies suggest that poor maternal nutrition during pregnancy increases the risk of obesity or diabetes in offspring, so it is highly important to intervene during pregnancy to prevent metabolic disorders in mothers and their offspring. Polyphenols with anti-inflammatory and antioxidant properties are found in many foods and have protective effects on obesity, diabetes, cancer, and cardiovascular disease. Furthermore, recent evidence indicates that maternal dietary polyphenols could be a potential therapy for improving pregnancy outcomes and offspring metabolism. In this review, we discuss the studies and mechanisms of different kinds of maternal dietary polyphenols during pregnancy and lactation in improving the metabolism of offspring, analyze the limitations of the current studies, and propose possible directions of further research, which provide new ideas and directions for reducing metabolic diseases in offspring.

Pectin, a complex dietary fiber, constitutes a key structural component of the cell walls of numerous edible plant products. It is resistant to digestion by human enzymes and undergoes depolymerization and saccharification in the gastrointestinal tract through the action of carbohydrate-active enzymes (CAZymes) produced by gut microbiota. This enzymatic breakdown generates intermediate structural fragments, which are subsequently converted into pectin oligosaccharides (POS) and monosaccharides. POS exhibit prebiotic properties and have demonstrated potential health benefits, including anti-carcinogenic effects, mucoadhesive capabilities, and the promotion of beneficial gut bacterial growth. However, the current understanding of the molecular structure of pectin and its degradation dynamics remains fragmented within the literature, impeding progress in dietary fiber intervention research and the development of personalized nutrition approaches. This review aims to provide a comprehensive overview of the structural features of pectin and the intricate breakdown mechanisms orchestrated by CAZymes. It underscores the complex architecture of pectin that influences its breakdown dynamics and specifies the enzymatic requirements for the cleavage of its diverse structural components. These insights complement our accompanying review on the structure-function relationships between pectin and the human gut microbiota, previously published in this journal.

N-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are essential for physiological requirements and disease prevention throughout life but are not adequately consumed worldwide. Dietary supplementation with plant-derived α-linolenic acid (ALA) has the potential to rebalance the fatty acid profile and enhance health benefits but faces challenges such as high β-oxidation consumption, low hepatic conversion efficiency, and high oxidative susceptibility under stress. This review focuses on the metabolic fate and potential regulatory targets of ALA-containing lipids in vivo, specifically the pathway from the gastrointestinal tract to the lymph, blood circulation, and liver. We propose a hypothesis that positively regulates the conversion of ALA into n-3 LCPUFAs based on the model of "fast" or "slow" absorption, transport, and hepatic metabolic fate. Furthermore, the potential effects of dietary nutrients on the metabolic conversion of ALA into n-3 LCPUFAs are discussed. The conversion of ALA is differentially regulated by structured lipids, phospholipids, other lipids, carbohydrates, specific proteins, amino acids, polyphenols, vitamins, and minerals. Future research should focus on designing a steady-state and precise delivery system for ALA, coupled with specific nutrients or phytochemicals, to effectively improve its metabolic conversion and ultimately achieve synergistic regulation of nutrition and health effects.

The transition from breastmilk to solid foods (weaning) is a decisive stage for the development of the colonic microbiota. However, little is known about how complementary foods influence the composition and function of the colonic microbiota in infants. This systematic review collected evidence of the effect of individual foods on the fecal microbiota of weaning infants (4-12 months old) using five databases: PubMed, CENTRAL, Scopus, Web of Science, and ScienceDirect. A total of 3625 records were examined, and seven randomized clinical trials met the review's eligibility criteria. Altogether, 983 participants were enrolled, and plant-based foods, meats, and dairy products were used as interventions. Wholegrain cereal increased the fecal abundance of the order Bacteroidales in the two included studies. Pureed beef increased the fecal abundances of the genus Bacteroides and the Clostridium XIVa group, as well as microbial richness in two of the three included studies. However, the conclusions of this review are limited by the small number of studies included. No conclusions could be drawn about the impact of complementary foods on fecal metabolites. Further clinical trials assessing the effect of dietary interventions on both fecal microbial composition and function are needed to fill this knowledge gap in infant nutrition.

Collagen, recognized as a fundamental protein present in biological tissues and structures, plays a crucial role in maintaining organ structure and tissue integrity. Microbial collagenases are specific for the degradation of collagen. The specific three-stranded helix region of natural collagen can be identified and hydrolyzed by microbial collagenases under physiological conditions, producing collagen peptides with high physiological activity. This article describes microbial collagenases, providing an introduction to the structure, physiological characteristics, factors affecting enzyme activity, and hydrolysis mechanisms of various classes of these enzymes. Microbial collagenase is the most widely used class of collagenase and plays an important role in all aspects of human life, and various applications of microbial collagenases in food industry, healthcare and environmental protection will be addressed in this review. In addition to its beneficial functions, microbial collagenase can exist as a virulence factor for pathogenic bacteria, and enhanced research on its structure and mechanism of action will help us to investigate more effective inhibitors as well as therapeutic agents and tools for the treatment of the corresponding diseases. Finally, this review critically analyses existing challenges and outlines prospects for future advancements in the field.

The structural molecules and conformational variations of soybean β-conglycinin/glycinin are crucial in defining the characteristics of protein-based foods. Recently, significant attention has been focused on the characteristics of soybean β-conglycinin/glycinin across various fields, particularly their structure and application. The research contributes to expanding the application fields of soybean protein-related component in food industry. This research generally concerned on, but not limited to, the novel substitution of animal-originated foods based on globulins and the deeper precising protein nutrition support. Furthermore, the innovative applications and future development of soybean globulins are presented, focusing on plant-based substitutes and advanced materials. This paper provides a comprehensive review of soybean β-conglycinin/glycinin, focusing on structural characteristics, techno-functionalities, innovation applications, and future prospects, supported by diverse citation and analyses. Additionally, the article introduces various methods for modifying soybean globulins, including physical, chemical, and biological treatments. Furthermore, the innovative applications and future development of soybean globulins are presented, focusing on plant-based substitutes and advanced materials. Despite extensive discussion on globulin applications in diverse food forms, the discourse on their flavor and safety is insufficient. Addressing these limitations is essential for a comprehensive understanding and effective utilization of soybean globulins.

Acrylamide (AA), a compound formed during the thermal processing of high-carbohydrate foods, has been implicated in the onset and progression of neurodegenerative diseases. An increasing number of reports support that gut microbiota plays a significant role in brain function and diseases, suggesting it may act as a mediator between AA exposure and the development of neurodegenerative diseases. Available studies have shown that AA intake affects the composition of the gut microbiota and the integrity of the intestinal barrier, both of which are often thought to be associated with the pathogenesis of neurodegenerative diseases, given the numerous evidences linking gut microbiota with the brain. Based on the current understanding, this paper discusses that AA induces the onset and progression of neurodegenerative diseases by disrupting the composition of the gut microbiota and the structure of the intestinal barrier. Furthermore, it explores the interaction between probiotics and AA exposure, as well as the potential for polysaccharides and polyphenols to improve the gut microenvironment, which provides novel perspectives on modulating the neurodegenerative diseases caused by AA exposure through diet.

Antimicrobial resistance (AMR) poses a global public health concern. Recognizing the critical role of bacterial adhesion in pathogenesis of infection, anti-adhesive therapy emerges as a promising approach to impede initial bacterial attachment, thus preventing pathogenic colonization and infection. Natural anti-adhesive agents derived from food sources are generally safe and have the potential to inhibit the emergence of resistant bacteria. This comprehensive review explored diverse natural dietary components exhibiting anti-adhesive activities against several model enteric pathogens, including Helicobacter pylori, Salmonella enterica, Clostridium difficile, and three key diarrheagenic Escherichia coli (i.e., enterotoxigenic E. coli, enteropathogenic E. coli, and enterohemorrhagic E. coli). Investigating various anti-adhesive products will advance our understanding of current research of the field and inspire further development of these agents as potential nutraceuticals or adjuvants to improve the efficacy of conventional antibiotics.

Honey analysis plays a crucial role in ensuring its quality, authenticity, and compliance with regulatory standards. Traditional methods for honey analysis are often time-consuming, labor-intensive, and require complex sample preparation. Infrared spectroscopy is used in the food sector as a fast and reliable technique for the analysis of food. Multivariate analysis applied to infrared spectroscopy has proved to be effective in analyzing honey. In this paper, recently published studies using mid- and near- infrared spectroscopy for the analysis of honey will be reviewed. Honey analysis covers the following objectives: the determination of the physiochemical properties, the determination of the antioxidant activity, the detection of adulteration, the determination of 5-(hydroxymethyl) furfural (HMF) and diastase activity, and the determination of the botanical and geographical origins. A summary of the basic principles of infrared spectroscopy is presented. Different data preprocessing techniques are described. Moreover, this article emphasizes the wide application of chemometrics or multivariate analysis tools for data treatment.