Polyphenols have received considerable attention for their promotive effects on colonic health. However, polyphenols are mostly sensitive to harsh gastrointestinal environments, thus, must be protected. It is necessary to design and develop a colon-targeted delivery system to improve the stability, colon-targeting and bioavailability of polyphenols. This paper mainly introduces research on colon-targeted controlled release of polyphenols. The physiological features affecting the dissolution, release and absorption of polyphenol-loaded delivery systems in the colon are first discussed. Simultaneously, the types of colon-targeted carriers with different release mechanisms are described, and colon-targeting assessment models that have been studied so far and their advantages and limitations are summarized. Based on the current research on polyphenols colon-targeting, outlook and reflections are proposed, with the goal of inspiring strategic development of new colon-targeted therapeutics to ensure that the polyphenols reach the colon with complete bioactivity.
{"title":"Colon-targeted delivery of polyphenols: construction principles, targeting mechanisms and evaluation methods.","authors":"Yidi Wang, Zhiying Li, Yiwen Bao, Huijun Cui, Jiaxin Li, Baoge Song, Mengzhu Wang, Haikun Li, Xingyue Cui, Yi Chen, Wei Chen, Shufang Yang, Yiyun Yang, Zhufeng Jin, Xu Si, Bin Li","doi":"10.1080/10408398.2023.2266842","DOIUrl":"10.1080/10408398.2023.2266842","url":null,"abstract":"<p><p>Polyphenols have received considerable attention for their promotive effects on colonic health. However, polyphenols are mostly sensitive to harsh gastrointestinal environments, thus, must be protected. It is necessary to design and develop a colon-targeted delivery system to improve the stability, colon-targeting and bioavailability of polyphenols. This paper mainly introduces research on colon-targeted controlled release of polyphenols. The physiological features affecting the dissolution, release and absorption of polyphenol-loaded delivery systems in the colon are first discussed. Simultaneously, the types of colon-targeted carriers with different release mechanisms are described, and colon-targeting assessment models that have been studied so far and their advantages and limitations are summarized. Based on the current research on polyphenols colon-targeting, outlook and reflections are proposed, with the goal of inspiring strategic development of new colon-targeted therapeutics to ensure that the polyphenols reach the colon with complete bioactivity.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"64-86"},"PeriodicalIF":7.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41194132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Milk proteins (MPs) have been widely used in the food industry due to their excellent functionalities. However, MPs are thermal-unstable substances and their functional properties are easily affected by heat treatment. Emerging non-thermal approaches (i.e., high-pressure homogenization (HPH), ultrasound (US), pulsed electric field (PEF)) have been increasingly popular. A detailed understanding of these approaches' impacts on the structure and functionalities of MPs can provide theoretical guidance for further development to accelerate their industrialization.
Scope and approach: This review assesses the mechanisms of HPH, US and PEF technologies on the structure and functionalities of MPs from molecular, mesoscopic and macroscopic levels, elucidates the modifications of MPs by these theologies combined with other methods, and further discusses their existing issues and the development in the food filed.
Key findings and conclusions: The structure of MPs changed after HPH, US and PEF treatment, affecting their functionalities. The changes in these properties of MPs are related to treated-parameters of used-technologies, the concentration of MPs, as well as molecular properties. Additionally, these technologies combined with other methods could obtain some outstanding functional properties for MPs. If properly managed, these theologies can be tailored for manufacturing superior functional MPs for various processing fields.
{"title":"Non-thermal techniques as an approach to modify the structure of milk proteins and improve their functionalities: a review of novel preparation.","authors":"Ruijie Shi, Zhishen Mu, Jialun Hu, Zhanmei Jiang, Juncai Hou","doi":"10.1080/10408398.2023.2263571","DOIUrl":"10.1080/10408398.2023.2263571","url":null,"abstract":"<p><strong>Background: </strong>Milk proteins (MPs) have been widely used in the food industry due to their excellent functionalities. However, MPs are thermal-unstable substances and their functional properties are easily affected by heat treatment. Emerging non-thermal approaches (i.e., high-pressure homogenization (HPH), ultrasound (US), pulsed electric field (PEF)) have been increasingly popular. A detailed understanding of these approaches' impacts on the structure and functionalities of MPs can provide theoretical guidance for further development to accelerate their industrialization.</p><p><strong>Scope and approach: </strong>This review assesses the mechanisms of HPH, US and PEF technologies on the structure and functionalities of MPs from molecular, mesoscopic and macroscopic levels, elucidates the modifications of MPs by these theologies combined with other methods, and further discusses their existing issues and the development in the food filed.</p><p><strong>Key findings and conclusions: </strong>The structure of MPs changed after HPH, US and PEF treatment, affecting their functionalities. The changes in these properties of MPs are related to treated-parameters of used-technologies, the concentration of MPs, as well as molecular properties. Additionally, these technologies combined with other methods could obtain some outstanding functional properties for MPs. If properly managed, these theologies can be tailored for manufacturing superior functional MPs for various processing fields.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"1-29"},"PeriodicalIF":7.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41178263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2023-10-26DOI: 10.1080/10408398.2023.2270530
Chengyu Jin, Abel Wend-Soo Zongo, Hengjun Du, Yuanchao Lu, Ningxiang Yu, Xiaohua Nie, Ashton Ma, Qin Ye, Hang Xiao, Xianghe Meng
Gardenia fruit (GF) is the mature fruit of Gardenia jasminoides Ellis, boasting a rich array of nutrients and phytochemicals. Over time, GF has been extensively utilized in both food and medicinal contexts. In recent years, numerous studies have delved into the chemical constituents of GF and their associated pharmacological activities, encompassing its phytochemical composition and health-promoting properties. This review aims to provide a critical and comprehensive summary of GF research, covering nutrient content, extraction technologies, and potential health benefits, offering new avenues for future investigations and highlighting its potential as an innovative food resource. Additionally, the review proposes novel industrial applications for GF, such as utilizing gardenia yellow/red/blue pigments in the food industry and incorporating it with other herbs in traditional Chinese medicine. By addressing current challenges in developing GF-related products, this work provides insights for potential applications in the cosmetics, food, and health products industries. Notably, there is a need for the development of more efficient extraction methods to harness the nutritional components of GF fully. Further research is needed to understand the specific molecular mechanisms underlying its bioactivities. Exploring advanced processing techniques to create innovative GF-derived products will show great promise for the future.
{"title":"Gardenia (<i>Gardenia jasminoides</i> Ellis) fruit: a critical review of its functional nutrients, processing methods, health-promoting effects, comprehensive application and future tendencies.","authors":"Chengyu Jin, Abel Wend-Soo Zongo, Hengjun Du, Yuanchao Lu, Ningxiang Yu, Xiaohua Nie, Ashton Ma, Qin Ye, Hang Xiao, Xianghe Meng","doi":"10.1080/10408398.2023.2270530","DOIUrl":"10.1080/10408398.2023.2270530","url":null,"abstract":"<p><p>Gardenia fruit (GF) is the mature fruit of Gardenia jasminoides Ellis, boasting a rich array of nutrients and phytochemicals. Over time, GF has been extensively utilized in both food and medicinal contexts. In recent years, numerous studies have delved into the chemical constituents of GF and their associated pharmacological activities, encompassing its phytochemical composition and health-promoting properties. This review aims to provide a critical and comprehensive summary of GF research, covering nutrient content, extraction technologies, and potential health benefits, offering new avenues for future investigations and highlighting its potential as an innovative food resource. Additionally, the review proposes novel industrial applications for GF, such as utilizing gardenia yellow/red/blue pigments in the food industry and incorporating it with other herbs in traditional Chinese medicine. By addressing current challenges in developing GF-related products, this work provides insights for potential applications in the cosmetics, food, and health products industries. Notably, there is a need for the development of more efficient extraction methods to harness the nutritional components of GF fully. Further research is needed to understand the specific molecular mechanisms underlying its bioactivities. Exploring advanced processing techniques to create innovative GF-derived products will show great promise for the future.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"165-192"},"PeriodicalIF":7.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50161033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-25DOI: 10.1080/10408398.2024.2439040
Lecheng Li, Xiaojing Li, David Julian McClements, Zhengyu Jin, Hangyan Ji, Chao Qiu
There is growing concern about the potential risks posed by synthetic additives in industrial products, such as foods, cosmetics, agrochemicals, and personal care products. Many plant-derived essential oils (EOs) have been shown to exhibit excellent antibacterial, antifungal, antiviral, and antioxidant activities, and may therefore be used as natural preservatives in these applications. However, most EOs have relatively low water solubility and are prone to chemical degradation during storage. The degradation products of EOs can be toxic and may not be able to fully exert their biological activity, which limits their application. Typically, these challenges can be overcome by encapsulating the essential oil in an appropriate colloid delivery system. This article begins by reviewing the sources, extraction, and activity mechanisms of EOs, and then highlights plant-based encapsulation technologies that can be used to enhance their efficacy. Finally, the potential applications of plant essential oil encapsulation system are discussed.
{"title":"Recent progress in the source, extraction, activity mechanism and encapsulation of bioactive essential oils.","authors":"Lecheng Li, Xiaojing Li, David Julian McClements, Zhengyu Jin, Hangyan Ji, Chao Qiu","doi":"10.1080/10408398.2024.2439040","DOIUrl":"https://doi.org/10.1080/10408398.2024.2439040","url":null,"abstract":"<p><p>There is growing concern about the potential risks posed by synthetic additives in industrial products, such as foods, cosmetics, agrochemicals, and personal care products. Many plant-derived essential oils (EOs) have been shown to exhibit excellent antibacterial, antifungal, antiviral, and antioxidant activities, and may therefore be used as natural preservatives in these applications. However, most EOs have relatively low water solubility and are prone to chemical degradation during storage. The degradation products of EOs can be toxic and may not be able to fully exert their biological activity, which limits their application. Typically, these challenges can be overcome by encapsulating the essential oil in an appropriate colloid delivery system. This article begins by reviewing the sources, extraction, and activity mechanisms of EOs, and then highlights plant-based encapsulation technologies that can be used to enhance their efficacy. Finally, the potential applications of plant essential oil encapsulation system are discussed.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"1-19"},"PeriodicalIF":7.3,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-23DOI: 10.1080/10408398.2024.2442062
Monica Marilena Miazzi, Maria Dellino, Valentina Fanelli, Isabella Mascio, Domenica Nigro, Claudio De Giovanni, Cinzia Montemurro
Given the rapidly increasing global demand for food, it is mandatory to consider new sources of nutrients, safe and sustainably produced protein foods to complement the current traditional and limited sources of protein in the human diet. In recent years, a wide range of nontraditional protein foods have been explored, prompting the European Union to legislate on how novel foods can be introduced and traded on the European market to ensure their safety. This review will illustrate the range of novel foods authorized in the EU and their potential impact on human health, highlighting the gaps, the potential risks, and the future research opportunities and perspectives.
{"title":"Novel foods in the European framework: benefits and risks.","authors":"Monica Marilena Miazzi, Maria Dellino, Valentina Fanelli, Isabella Mascio, Domenica Nigro, Claudio De Giovanni, Cinzia Montemurro","doi":"10.1080/10408398.2024.2442062","DOIUrl":"https://doi.org/10.1080/10408398.2024.2442062","url":null,"abstract":"<p><p>Given the rapidly increasing global demand for food, it is mandatory to consider new sources of nutrients, safe and sustainably produced protein foods to complement the current traditional and limited sources of protein in the human diet. In recent years, a wide range of nontraditional protein foods have been explored, prompting the European Union to legislate on how novel foods can be introduced and traded on the European market to ensure their safety. This review will illustrate the range of novel foods authorized in the EU and their potential impact on human health, highlighting the gaps, the potential risks, and the future research opportunities and perspectives.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":7.3,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-23DOI: 10.1080/10408398.2024.2442527
Mariana Maçãs, Bárbara Biduski, Alessandro Ferragina, Antonia Al Dos Santos, Melanie Huet, Elke K Arendt, Eimear Gallagher
An increasing consumer demand for plant-based and high-protein options, motivated by health and sustainability, has resulted in a surge of food innovation in this area. Incorporating alternative plant sources, such as pulses and pseudocereals, has been proven to enhance the nutritional profile of baked products. However, these can also negatively impact the yeasted bread acceptability. In the bakery sector, it is crucial to consider how incorporating non-wheat ingredients influences product quality. Consequently, exploring effective treatments/processing methods becomes essential to minimize the impact of alternative plant ingredient additions. This review explores conventional and emerging processing approaches for alternative plant materials and discusses the nutritional value may be enhanced while maintaining high acceptability. A meta-analysis was undertaken to visualize the influence of plant processing technologies on product quality, specifically on loaf-specific volume and crumb texture. This review highlighted the importance of conventional processing methods when applied to bread. Additionally revealed the potential of emerging processing which can positively affect a loaf volume and texture when compared with non-processed plant ingredients. Such studies enabled the production of acceptable bakery products with higher levels of alternative ingredient incorporation. However, increased use of emerging technologies is dependent on further research and overcoming scaling-up difficulties.
{"title":"Impact of conventional and emerging processing methods on alternative breads- a comprehensive review and meta-analysis.","authors":"Mariana Maçãs, Bárbara Biduski, Alessandro Ferragina, Antonia Al Dos Santos, Melanie Huet, Elke K Arendt, Eimear Gallagher","doi":"10.1080/10408398.2024.2442527","DOIUrl":"https://doi.org/10.1080/10408398.2024.2442527","url":null,"abstract":"<p><p>An increasing consumer demand for plant-based and high-protein options, motivated by health and sustainability, has resulted in a surge of food innovation in this area. Incorporating alternative plant sources, such as pulses and pseudocereals, has been proven to enhance the nutritional profile of baked products. However, these can also negatively impact the yeasted bread acceptability. In the bakery sector, it is crucial to consider how incorporating non-wheat ingredients influences product quality. Consequently, exploring effective treatments/processing methods becomes essential to minimize the impact of alternative plant ingredient additions. This review explores conventional and emerging processing approaches for alternative plant materials and discusses the nutritional value may be enhanced while maintaining high acceptability. A meta-analysis was undertaken to visualize the influence of plant processing technologies on product quality, specifically on loaf-specific volume and crumb texture. This review highlighted the importance of conventional processing methods when applied to bread. Additionally revealed the potential of emerging processing which can positively affect a loaf volume and texture when compared with non-processed plant ingredients. Such studies enabled the production of acceptable bakery products with higher levels of alternative ingredient incorporation. However, increased use of emerging technologies is dependent on further research and overcoming scaling-up difficulties.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"1-21"},"PeriodicalIF":7.3,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The early intrauterine environment of mothers during pregnancy significantly affects the metabolic health of their offspring. Existing studies suggest that poor maternal nutrition during pregnancy increases the risk of obesity or diabetes in offspring, so it is highly important to intervene during pregnancy to prevent metabolic disorders in mothers and their offspring. Polyphenols with anti-inflammatory and antioxidant properties are found in many foods and have protective effects on obesity, diabetes, cancer, and cardiovascular disease. Furthermore, recent evidence indicates that maternal dietary polyphenols could be a potential therapy for improving pregnancy outcomes and offspring metabolism. In this review, we discuss the studies and mechanisms of different kinds of maternal dietary polyphenols during pregnancy and lactation in improving the metabolism of offspring, analyze the limitations of the current studies, and propose possible directions of further research, which provide new ideas and directions for reducing metabolic diseases in offspring.
{"title":"The effect of maternal dietary polyphenol consumption on offspring metabolism.","authors":"Jing Zhou, Yaolin Ren, Jie Yu, Yuan Zeng, Jing Ren, Yifan Wu, Qian Zhang, Xinhua Xiao","doi":"10.1080/10408398.2024.2442539","DOIUrl":"https://doi.org/10.1080/10408398.2024.2442539","url":null,"abstract":"<p><p>The early intrauterine environment of mothers during pregnancy significantly affects the metabolic health of their offspring. Existing studies suggest that poor maternal nutrition during pregnancy increases the risk of obesity or diabetes in offspring, so it is highly important to intervene during pregnancy to prevent metabolic disorders in mothers and their offspring. Polyphenols with anti-inflammatory and antioxidant properties are found in many foods and have protective effects on obesity, diabetes, cancer, and cardiovascular disease. Furthermore, recent evidence indicates that maternal dietary polyphenols could be a potential therapy for improving pregnancy outcomes and offspring metabolism. In this review, we discuss the studies and mechanisms of different kinds of maternal dietary polyphenols during pregnancy and lactation in improving the metabolism of offspring, analyze the limitations of the current studies, and propose possible directions of further research, which provide new ideas and directions for reducing metabolic diseases in offspring.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"1-18"},"PeriodicalIF":7.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p><strong>Background: </strong>The current knowledge about the efficacy and safety of dietary polyphenol administration in patients with polycystic ovarian syndrome (PCOS) is divergent.</p><p><strong>Objective: </strong>To evaluate the pooled efficacy and safety of dietary polyphenol administration in the treatment of patients with PCOS.</p><p><strong>Methods: </strong>The pubmed, Embase, Scopus, Cochrane Library, and Web of Science databases were searched for randomized controlled trials (RCTs) of dietary polyphenol administration for the treatment of PCOS. English-language RCTs involving adults with PCOS were thoroughly searched in electronic databases from the time of their establishment to May 2024. Random-effects models were used because heterogeneity was derived from differences in intervention materials and study duration, among other confounding factors. The effect sizes of the outcomes in the pooled analysis are expressed as weighted mean differences (WMDs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A total of 15 RCTs involving 934 patients were finally included. Compared with control treatments, dietary polyphenol administration significantly reduced luteinizing hormone (LH) (WMD: -0.85, 95% CI [-1.32 to -0.38], <i>p</i> = 0.00), and prolactin levels (WMD: -3.73, 95% CI [-6.73 to -0.74], <i>p</i> = 0.01). Dietary polyphenol administration significantly reduced insulin levels (WMD: -0.85, 95% CI [-1.32 to -0.38], <i>p</i> = 0.00). Regarding lipid metabolism, dietary polyphenol administration only reduced triglyceride levels (WMD: -8.96, 95% CI [-16.44 to -1.49], <i>p</i> = 0.02). Malondialdehyde (MDA) (WMD: -0.65, 95% CI [-0.68 to -0.62], <i>p</i> = 0.00), tumor necrosis factor (TNF-α) (WMD: -1.39, 95% CI [-2.41 to -0.37], <i>p</i> = 0.01) concentrations were significantly reduced by dietary polyphenol administration. None of the interventions significantly affected weight, body mass index (BMI), waist circumference (WC), homeostatic model-insulin resistance (HOMA-IR), fasting blood sugar (FBS), glycated hemoglobin (HBA1c), follicle-stimulating hormone (FSH), testosterone (T), dehydroepiandrosterone (DHEA), estradiol (E2), anti-Müllerian hormone (AMH), quantitative insulin-sensitivity check index (QUICKI), sex hormone-binding globulin (SHBG), total antioxidant capacity (TAC), C-peptide, C-reactive protein (CRP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, cholesterol/HDL, acne score, thyroid-stimulating hormone (TSH), aspartate aminotransferase (AST), alanine aminotransferase (ALT) or alkaline phosphatase (ALP).</p><p><strong>Conclusion: </strong>Dietary polyphenol administration was efficacious in patients with PCOS in our study. This review might provide new insight into the treatment of patients with PCOS and the potential of daily polyphenol supplementation in patients with PCOS. Nevertheless, these results must be interpreted carefully as a result of the heterogeneity and ris
背景:目前关于多囊卵巢综合征(PCOS)患者膳食多酚的疗效和安全性的认识存在分歧。目的:评价膳食多酚治疗多囊卵巢综合征的综合疗效和安全性。方法:检索pubmed、Embase、Scopus、Cochrane Library和Web of Science数据库,检索膳食多酚治疗PCOS的随机对照试验(rct)。对涉及成人多囊卵巢综合征的英语随机对照试验从建立之日起至2024年5月在电子数据库中进行全面检索。使用随机效应模型是因为异质性来源于干预材料和研究持续时间的差异,以及其他混杂因素。合并分析结果的效应量用加权平均差(wmd)和95%置信区间(ci)表示。结果:最终纳入15项rct,共934例患者。与对照组相比,饲粮多酚处理显著降低了黄体生成素(LH) (WMD: -0.85, 95% CI [-1.32 ~ -0.38], p = 0.00)和催乳素水平(WMD: -3.73, 95% CI [-6.73 ~ -0.74], p = 0.01)。膳食多酚可显著降低胰岛素水平(WMD: -0.85, 95% CI [-1.32 ~ -0.38], p = 0.00)。在脂质代谢方面,膳食多酚只降低了甘油三酯水平(WMD: -8.96, 95% CI[-16.44至-1.49],p = 0.02)。多酚组丙二醛(MDA) (WMD: -0.65, 95% CI [-0.68 ~ -0.62], p = 0.00)、肿瘤坏死因子(TNF-α) (WMD: -1.39, 95% CI [-2.41 ~ -0.37], p = 0.01)浓度显著降低。所有干预措施均未显著影响体重、体重指数(BMI)、腰围(WC)、稳态模型胰岛素抵抗(HOMA-IR)、空腹血糖(FBS)、糖化血红蛋白(HBA1c)、促卵泡激素(FSH)、睾酮(T)、脱氢表雄酮(DHEA)、雌二醇(E2)、抗勒氏激素(AMH)、胰岛素定量敏感性检查指数(QUICKI)、性激素结合球蛋白(SHBG)、总抗氧化能力(TAC)、c肽、c反应蛋白(CRP)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、胆固醇、胆固醇/HDL、痤疮评分、促甲状腺激素(TSH)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)或碱性磷酸酶(ALP)。结论:膳食多酚治疗多囊卵巢综合征是有效的。这一综述可能为多囊卵巢综合征患者的治疗和多囊卵巢综合征患者每日补充多酚的潜力提供新的见解。然而,由于研究的异质性和偏倚风险,这些结果必须仔细解释,我们期望将来会进行更多高质量的随机对照试验来评估膳食多酚给药对PCOS患者的疗效和安全性。系统评价注册:CRD42024498494。
{"title":"Efficacy and safety of dietary polyphenol administration as assessed by hormonal, glycolipid metabolism, inflammation and oxidative stress parameters in patients with PCOS: a meta-analysis and systematic review.","authors":"Xian Jian, Chen Shi, Tongtong Xu, Boya Liu, Liyuan Zhou, Lili Jiang, Kuiran Liu","doi":"10.1080/10408398.2024.2440063","DOIUrl":"https://doi.org/10.1080/10408398.2024.2440063","url":null,"abstract":"<p><strong>Background: </strong>The current knowledge about the efficacy and safety of dietary polyphenol administration in patients with polycystic ovarian syndrome (PCOS) is divergent.</p><p><strong>Objective: </strong>To evaluate the pooled efficacy and safety of dietary polyphenol administration in the treatment of patients with PCOS.</p><p><strong>Methods: </strong>The pubmed, Embase, Scopus, Cochrane Library, and Web of Science databases were searched for randomized controlled trials (RCTs) of dietary polyphenol administration for the treatment of PCOS. English-language RCTs involving adults with PCOS were thoroughly searched in electronic databases from the time of their establishment to May 2024. Random-effects models were used because heterogeneity was derived from differences in intervention materials and study duration, among other confounding factors. The effect sizes of the outcomes in the pooled analysis are expressed as weighted mean differences (WMDs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A total of 15 RCTs involving 934 patients were finally included. Compared with control treatments, dietary polyphenol administration significantly reduced luteinizing hormone (LH) (WMD: -0.85, 95% CI [-1.32 to -0.38], <i>p</i> = 0.00), and prolactin levels (WMD: -3.73, 95% CI [-6.73 to -0.74], <i>p</i> = 0.01). Dietary polyphenol administration significantly reduced insulin levels (WMD: -0.85, 95% CI [-1.32 to -0.38], <i>p</i> = 0.00). Regarding lipid metabolism, dietary polyphenol administration only reduced triglyceride levels (WMD: -8.96, 95% CI [-16.44 to -1.49], <i>p</i> = 0.02). Malondialdehyde (MDA) (WMD: -0.65, 95% CI [-0.68 to -0.62], <i>p</i> = 0.00), tumor necrosis factor (TNF-α) (WMD: -1.39, 95% CI [-2.41 to -0.37], <i>p</i> = 0.01) concentrations were significantly reduced by dietary polyphenol administration. None of the interventions significantly affected weight, body mass index (BMI), waist circumference (WC), homeostatic model-insulin resistance (HOMA-IR), fasting blood sugar (FBS), glycated hemoglobin (HBA1c), follicle-stimulating hormone (FSH), testosterone (T), dehydroepiandrosterone (DHEA), estradiol (E2), anti-Müllerian hormone (AMH), quantitative insulin-sensitivity check index (QUICKI), sex hormone-binding globulin (SHBG), total antioxidant capacity (TAC), C-peptide, C-reactive protein (CRP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, cholesterol/HDL, acne score, thyroid-stimulating hormone (TSH), aspartate aminotransferase (AST), alanine aminotransferase (ALT) or alkaline phosphatase (ALP).</p><p><strong>Conclusion: </strong>Dietary polyphenol administration was efficacious in patients with PCOS in our study. This review might provide new insight into the treatment of patients with PCOS and the potential of daily polyphenol supplementation in patients with PCOS. Nevertheless, these results must be interpreted carefully as a result of the heterogeneity and ris","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"1-25"},"PeriodicalIF":7.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-16DOI: 10.1080/10408398.2024.2437573
Ecem Yüksel, Remco Kort, Alphons G J Voragen
Pectin, a complex dietary fiber, constitutes a key structural component of the cell walls of numerous edible plant products. It is resistant to digestion by human enzymes and undergoes depolymerization and saccharification in the gastrointestinal tract through the action of carbohydrate-active enzymes (CAZymes) produced by gut microbiota. This enzymatic breakdown generates intermediate structural fragments, which are subsequently converted into pectin oligosaccharides (POS) and monosaccharides. POS exhibit prebiotic properties and have demonstrated potential health benefits, including anti-carcinogenic effects, mucoadhesive capabilities, and the promotion of beneficial gut bacterial growth. However, the current understanding of the molecular structure of pectin and its degradation dynamics remains fragmented within the literature, impeding progress in dietary fiber intervention research and the development of personalized nutrition approaches. This review aims to provide a comprehensive overview of the structural features of pectin and the intricate breakdown mechanisms orchestrated by CAZymes. It underscores the complex architecture of pectin that influences its breakdown dynamics and specifies the enzymatic requirements for the cleavage of its diverse structural components. These insights complement our accompanying review on the structure-function relationships between pectin and the human gut microbiota, previously published in this journal.
{"title":"Structure and degradation dynamics of dietary pectin.","authors":"Ecem Yüksel, Remco Kort, Alphons G J Voragen","doi":"10.1080/10408398.2024.2437573","DOIUrl":"https://doi.org/10.1080/10408398.2024.2437573","url":null,"abstract":"<p><p>Pectin, a complex dietary fiber, constitutes a key structural component of the cell walls of numerous edible plant products. It is resistant to digestion by human enzymes and undergoes depolymerization and saccharification in the gastrointestinal tract through the action of carbohydrate-active enzymes (CAZymes) produced by gut microbiota. This enzymatic breakdown generates intermediate structural fragments, which are subsequently converted into pectin oligosaccharides (POS) and monosaccharides. POS exhibit prebiotic properties and have demonstrated potential health benefits, including anti-carcinogenic effects, mucoadhesive capabilities, and the promotion of beneficial gut bacterial growth. However, the current understanding of the molecular structure of pectin and its degradation dynamics remains fragmented within the literature, impeding progress in dietary fiber intervention research and the development of personalized nutrition approaches. This review aims to provide a comprehensive overview of the structural features of pectin and the intricate breakdown mechanisms orchestrated by CAZymes. It underscores the complex architecture of pectin that influences its breakdown dynamics and specifies the enzymatic requirements for the cleavage of its diverse structural components. These insights complement our accompanying review on the structure-function relationships between pectin and the human gut microbiota, previously published in this journal.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"1-20"},"PeriodicalIF":7.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-16DOI: 10.1080/10408398.2024.2442064
Lei Wang, Chen Cheng, Xiao Yu, Liang Guo, Xia Wan, Jiqu Xu, Xia Xiang, Jing Yang, Jingxuan Kang, Qianchun Deng
N-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are essential for physiological requirements and disease prevention throughout life but are not adequately consumed worldwide. Dietary supplementation with plant-derived α-linolenic acid (ALA) has the potential to rebalance the fatty acid profile and enhance health benefits but faces challenges such as high β-oxidation consumption, low hepatic conversion efficiency, and high oxidative susceptibility under stress. This review focuses on the metabolic fate and potential regulatory targets of ALA-containing lipids in vivo, specifically the pathway from the gastrointestinal tract to the lymph, blood circulation, and liver. We propose a hypothesis that positively regulates the conversion of ALA into n-3 LCPUFAs based on the model of "fast" or "slow" absorption, transport, and hepatic metabolic fate. Furthermore, the potential effects of dietary nutrients on the metabolic conversion of ALA into n-3 LCPUFAs are discussed. The conversion of ALA is differentially regulated by structured lipids, phospholipids, other lipids, carbohydrates, specific proteins, amino acids, polyphenols, vitamins, and minerals. Future research should focus on designing a steady-state and precise delivery system for ALA, coupled with specific nutrients or phytochemicals, to effectively improve its metabolic conversion and ultimately achieve synergistic regulation of nutrition and health effects.
{"title":"Conversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acids: bioavailability and dietary regulation.","authors":"Lei Wang, Chen Cheng, Xiao Yu, Liang Guo, Xia Wan, Jiqu Xu, Xia Xiang, Jing Yang, Jingxuan Kang, Qianchun Deng","doi":"10.1080/10408398.2024.2442064","DOIUrl":"https://doi.org/10.1080/10408398.2024.2442064","url":null,"abstract":"<p><p>N-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are essential for physiological requirements and disease prevention throughout life but are not adequately consumed worldwide. Dietary supplementation with plant-derived α-linolenic acid (ALA) has the potential to rebalance the fatty acid profile and enhance health benefits but faces challenges such as high β-oxidation consumption, low hepatic conversion efficiency, and high oxidative susceptibility under stress. This review focuses on the metabolic fate and potential regulatory targets of ALA-containing lipids <i>in vivo</i>, specifically the pathway from the gastrointestinal tract to the lymph, blood circulation, and liver. We propose a hypothesis that positively regulates the conversion of ALA into n-3 LCPUFAs based on the model of \"fast\" or \"slow\" absorption, transport, and hepatic metabolic fate. Furthermore, the potential effects of dietary nutrients on the metabolic conversion of ALA into n-3 LCPUFAs are discussed. The conversion of ALA is differentially regulated by structured lipids, phospholipids, other lipids, carbohydrates, specific proteins, amino acids, polyphenols, vitamins, and minerals. Future research should focus on designing a steady-state and precise delivery system for ALA, coupled with specific nutrients or phytochemicals, to effectively improve its metabolic conversion and ultimately achieve synergistic regulation of nutrition and health effects.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"1-33"},"PeriodicalIF":7.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}