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Colon-targeted delivery of polyphenols: construction principles, targeting mechanisms and evaluation methods. 多酚的结肠靶向递送:构建原理、靶向机制和评价方法。
IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-01-01 Epub Date: 2023-10-12 DOI: 10.1080/10408398.2023.2266842
Yidi Wang, Zhiying Li, Yiwen Bao, Huijun Cui, Jiaxin Li, Baoge Song, Mengzhu Wang, Haikun Li, Xingyue Cui, Yi Chen, Wei Chen, Shufang Yang, Yiyun Yang, Zhufeng Jin, Xu Si, Bin Li

Polyphenols have received considerable attention for their promotive effects on colonic health. However, polyphenols are mostly sensitive to harsh gastrointestinal environments, thus, must be protected. It is necessary to design and develop a colon-targeted delivery system to improve the stability, colon-targeting and bioavailability of polyphenols. This paper mainly introduces research on colon-targeted controlled release of polyphenols. The physiological features affecting the dissolution, release and absorption of polyphenol-loaded delivery systems in the colon are first discussed. Simultaneously, the types of colon-targeted carriers with different release mechanisms are described, and colon-targeting assessment models that have been studied so far and their advantages and limitations are summarized. Based on the current research on polyphenols colon-targeting, outlook and reflections are proposed, with the goal of inspiring strategic development of new colon-targeted therapeutics to ensure that the polyphenols reach the colon with complete bioactivity.

多酚因其对结肠健康的促进作用而受到广泛关注。然而,多酚类物质大多对恶劣的胃肠道环境敏感,因此必须加以保护。有必要设计和开发一种结肠靶向递送系统,以提高多酚的稳定性、结肠靶向性和生物利用度。本文主要介绍多酚类物质结肠靶向控制释放的研究进展。首先讨论了影响多酚负载递送系统在结肠中的溶解、释放和吸收的生理特征。同时,介绍了具有不同释放机制的结肠靶向载体的类型,并总结了迄今为止研究的结肠靶向性评估模型及其优点和局限性。基于目前多酚类结肠靶向药物的研究现状,提出了展望和思考,旨在激发新的结肠靶向治疗药物的战略发展,确保多酚类药物以完全的生物活性到达结肠。
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引用次数: 0
Non-thermal techniques as an approach to modify the structure of milk proteins and improve their functionalities: a review of novel preparation. 非热技术作为一种改变乳蛋白结构和提高其功能的方法:新制备方法综述。
IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-01-01 Epub Date: 2023-10-09 DOI: 10.1080/10408398.2023.2263571
Ruijie Shi, Zhishen Mu, Jialun Hu, Zhanmei Jiang, Juncai Hou

Background: Milk proteins (MPs) have been widely used in the food industry due to their excellent functionalities. However, MPs are thermal-unstable substances and their functional properties are easily affected by heat treatment. Emerging non-thermal approaches (i.e., high-pressure homogenization (HPH), ultrasound (US), pulsed electric field (PEF)) have been increasingly popular. A detailed understanding of these approaches' impacts on the structure and functionalities of MPs can provide theoretical guidance for further development to accelerate their industrialization.

Scope and approach: This review assesses the mechanisms of HPH, US and PEF technologies on the structure and functionalities of MPs from molecular, mesoscopic and macroscopic levels, elucidates the modifications of MPs by these theologies combined with other methods, and further discusses their existing issues and the development in the food filed.

Key findings and conclusions: The structure of MPs changed after HPH, US and PEF treatment, affecting their functionalities. The changes in these properties of MPs are related to treated-parameters of used-technologies, the concentration of MPs, as well as molecular properties. Additionally, these technologies combined with other methods could obtain some outstanding functional properties for MPs. If properly managed, these theologies can be tailored for manufacturing superior functional MPs for various processing fields.

背景:乳蛋白因其优异的功能性在食品工业中得到了广泛的应用。然而,MPs是热不稳定物质,其功能特性很容易受到热处理的影响。新兴的非热方法(即高压均化(HPH)、超声(US)、脉冲电场(PEF))越来越受欢迎。详细了解这些方法对MP结构和功能的影响,可以为进一步发展加快其工业化提供理论指导。范围和方法:本综述从分子、介观和宏观三个层面评估了HPH、US和PEF技术对MPs结构和功能的影响机制,阐述了这些神学与其他方法相结合对MPs的修饰,并进一步讨论了它们在食品领域存在的问题和发展。主要发现和结论:HPH、US和PEF治疗后,MP的结构发生变化,影响其功能。MPs这些性质的变化与所用技术的处理参数、MPs的浓度以及分子性质有关。此外,这些技术与其他方法相结合,可以获得MP的一些突出功能特性。如果管理得当,这些神学家可以为制造各种加工领域的卓越功能MP而量身定制。
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引用次数: 0
Gardenia (Gardenia jasminoides Ellis) fruit: a critical review of its functional nutrients, processing methods, health-promoting effects, comprehensive application and future tendencies. 栀子(Gardenia jasminoides Ellis)果实:对其功能性营养成分、加工方法、保健作用、综合应用及发展趋势进行了综述。
IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-01-01 Epub Date: 2023-10-26 DOI: 10.1080/10408398.2023.2270530
Chengyu Jin, Abel Wend-Soo Zongo, Hengjun Du, Yuanchao Lu, Ningxiang Yu, Xiaohua Nie, Ashton Ma, Qin Ye, Hang Xiao, Xianghe Meng

Gardenia fruit (GF) is the mature fruit of Gardenia jasminoides Ellis, boasting a rich array of nutrients and phytochemicals. Over time, GF has been extensively utilized in both food and medicinal contexts. In recent years, numerous studies have delved into the chemical constituents of GF and their associated pharmacological activities, encompassing its phytochemical composition and health-promoting properties. This review aims to provide a critical and comprehensive summary of GF research, covering nutrient content, extraction technologies, and potential health benefits, offering new avenues for future investigations and highlighting its potential as an innovative food resource. Additionally, the review proposes novel industrial applications for GF, such as utilizing gardenia yellow/red/blue pigments in the food industry and incorporating it with other herbs in traditional Chinese medicine. By addressing current challenges in developing GF-related products, this work provides insights for potential applications in the cosmetics, food, and health products industries. Notably, there is a need for the development of more efficient extraction methods to harness the nutritional components of GF fully. Further research is needed to understand the specific molecular mechanisms underlying its bioactivities. Exploring advanced processing techniques to create innovative GF-derived products will show great promise for the future.

栀子果实(GF)是栀子的成熟果实,具有丰富的营养成分和植物化学物质。随着时间的推移,GF已被广泛用于食品和医药领域。近年来,许多研究深入探讨了GF的化学成分及其相关药理活性,包括其植物化学成分和健康促进特性。这篇综述旨在对GF的研究进行批判性和全面的总结,涵盖营养成分、提取技术和潜在的健康益处,为未来的研究提供新的途径,并强调其作为创新食品资源的潜力。此外,该综述提出了GF的新的工业应用,例如在食品工业中利用栀子黄/红/蓝颜料,并将其与其他草药结合在中药中。通过解决当前开发GF相关产品的挑战,这项工作为化妆品、食品和健康产品行业的潜在应用提供了见解。值得注意的是,需要开发更有效的提取方法来充分利用GF的营养成分。需要进一步的研究来了解其生物活性的具体分子机制。探索先进的加工技术来创造创新的GF衍生产品将在未来显示出巨大的前景。
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引用次数: 0
Recent progress in the source, extraction, activity mechanism and encapsulation of bioactive essential oils. 生物活性精油的来源、提取、作用机理及包封研究进展。
IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-12-25 DOI: 10.1080/10408398.2024.2439040
Lecheng Li, Xiaojing Li, David Julian McClements, Zhengyu Jin, Hangyan Ji, Chao Qiu

There is growing concern about the potential risks posed by synthetic additives in industrial products, such as foods, cosmetics, agrochemicals, and personal care products. Many plant-derived essential oils (EOs) have been shown to exhibit excellent antibacterial, antifungal, antiviral, and antioxidant activities, and may therefore be used as natural preservatives in these applications. However, most EOs have relatively low water solubility and are prone to chemical degradation during storage. The degradation products of EOs can be toxic and may not be able to fully exert their biological activity, which limits their application. Typically, these challenges can be overcome by encapsulating the essential oil in an appropriate colloid delivery system. This article begins by reviewing the sources, extraction, and activity mechanisms of EOs, and then highlights plant-based encapsulation technologies that can be used to enhance their efficacy. Finally, the potential applications of plant essential oil encapsulation system are discussed.

人们越来越关注食品、化妆品、农用化学品和个人护理产品等工业产品中合成添加剂带来的潜在风险。许多植物源性精油(EOs)已被证明具有优异的抗菌、抗真菌、抗病毒和抗氧化活性,因此可以在这些应用中用作天然防腐剂。然而,大多数EOs的水溶性相对较低,并且在储存过程中容易发生化学降解。EOs的降解产物可能是有毒的,并且可能不能充分发挥其生物活性,这限制了它们的应用。通常,这些挑战可以通过将精油封装在适当的胶体输送系统中来克服。本文首先回顾了EOs的来源、提取和活性机制,然后重点介绍了可用于增强其功效的植物包封技术。最后,对植物精油包封系统的应用前景进行了展望。
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引用次数: 0
Novel foods in the European framework: benefits and risks. 欧洲框架下的新型食品:利益与风险。
IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-12-23 DOI: 10.1080/10408398.2024.2442062
Monica Marilena Miazzi, Maria Dellino, Valentina Fanelli, Isabella Mascio, Domenica Nigro, Claudio De Giovanni, Cinzia Montemurro

Given the rapidly increasing global demand for food, it is mandatory to consider new sources of nutrients, safe and sustainably produced protein foods to complement the current traditional and limited sources of protein in the human diet. In recent years, a wide range of nontraditional protein foods have been explored, prompting the European Union to legislate on how novel foods can be introduced and traded on the European market to ensure their safety. This review will illustrate the range of novel foods authorized in the EU and their potential impact on human health, highlighting the gaps, the potential risks, and the future research opportunities and perspectives.

鉴于全球对粮食的需求迅速增长,必须考虑新的营养来源、安全和可持续生产的蛋白质食品,以补充目前人类饮食中传统和有限的蛋白质来源。近年来,人们对各种非传统蛋白质食品进行了探索,促使欧盟立法规定如何在欧洲市场上引进和交易新型食品,以确保其安全性。本综述将阐述欧盟批准的新食品的范围及其对人类健康的潜在影响,强调差距、潜在风险以及未来的研究机会和前景。
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引用次数: 0
Impact of conventional and emerging processing methods on alternative breads- a comprehensive review and meta-analysis. 传统和新兴加工方法对替代面包的影响——一项综合综述和荟萃分析。
IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-12-23 DOI: 10.1080/10408398.2024.2442527
Mariana Maçãs, Bárbara Biduski, Alessandro Ferragina, Antonia Al Dos Santos, Melanie Huet, Elke K Arendt, Eimear Gallagher

An increasing consumer demand for plant-based and high-protein options, motivated by health and sustainability, has resulted in a surge of food innovation in this area. Incorporating alternative plant sources, such as pulses and pseudocereals, has been proven to enhance the nutritional profile of baked products. However, these can also negatively impact the yeasted bread acceptability. In the bakery sector, it is crucial to consider how incorporating non-wheat ingredients influences product quality. Consequently, exploring effective treatments/processing methods becomes essential to minimize the impact of alternative plant ingredient additions. This review explores conventional and emerging processing approaches for alternative plant materials and discusses the nutritional value may be enhanced while maintaining high acceptability. A meta-analysis was undertaken to visualize the influence of plant processing technologies on product quality, specifically on loaf-specific volume and crumb texture. This review highlighted the importance of conventional processing methods when applied to bread. Additionally revealed the potential of emerging processing which can positively affect a loaf volume and texture when compared with non-processed plant ingredients. Such studies enabled the production of acceptable bakery products with higher levels of alternative ingredient incorporation. However, increased use of emerging technologies is dependent on further research and overcoming scaling-up difficulties.

出于健康和可持续性的考虑,消费者对植物性和高蛋白食品的需求不断增加,导致这一领域的食品创新激增。加入替代植物来源,如豆类和假谷物,已被证明可以提高烘焙产品的营养成分。然而,这些也会对发酵面包的可接受性产生负面影响。在烘焙行业,考虑非小麦成分如何影响产品质量是至关重要的。因此,探索有效的处理/加工方法对于减少替代植物成分添加的影响至关重要。这篇综述探讨了替代植物材料的传统和新兴加工方法,并讨论了在保持高可接受性的同时可能提高的营养价值。进行了一项荟萃分析,以可视化植物加工技术对产品质量的影响,特别是对面包特定体积和面包屑质地的影响。这篇综述强调了传统加工方法在面包加工中的重要性。此外,与未加工的植物成分相比,揭示了新兴加工的潜力,它可以积极影响面包的体积和质地。这些研究使生产可接受的烘焙产品具有较高水平的替代成分的掺入。然而,新兴技术的更多使用取决于进一步的研究和克服扩大规模的困难。
{"title":"Impact of conventional and emerging processing methods on alternative breads- a comprehensive review and meta-analysis.","authors":"Mariana Maçãs, Bárbara Biduski, Alessandro Ferragina, Antonia Al Dos Santos, Melanie Huet, Elke K Arendt, Eimear Gallagher","doi":"10.1080/10408398.2024.2442527","DOIUrl":"https://doi.org/10.1080/10408398.2024.2442527","url":null,"abstract":"<p><p>An increasing consumer demand for plant-based and high-protein options, motivated by health and sustainability, has resulted in a surge of food innovation in this area. Incorporating alternative plant sources, such as pulses and pseudocereals, has been proven to enhance the nutritional profile of baked products. However, these can also negatively impact the yeasted bread acceptability. In the bakery sector, it is crucial to consider how incorporating non-wheat ingredients influences product quality. Consequently, exploring effective treatments/processing methods becomes essential to minimize the impact of alternative plant ingredient additions. This review explores conventional and emerging processing approaches for alternative plant materials and discusses the nutritional value may be enhanced while maintaining high acceptability. A meta-analysis was undertaken to visualize the influence of plant processing technologies on product quality, specifically on loaf-specific volume and crumb texture. This review highlighted the importance of conventional processing methods when applied to bread. Additionally revealed the potential of emerging processing which can positively affect a loaf volume and texture when compared with non-processed plant ingredients. Such studies enabled the production of acceptable bakery products with higher levels of alternative ingredient incorporation. However, increased use of emerging technologies is dependent on further research and overcoming scaling-up difficulties.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"1-21"},"PeriodicalIF":7.3,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of maternal dietary polyphenol consumption on offspring metabolism. 母体日粮多酚摄入对子代代谢的影响。
IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-12-19 DOI: 10.1080/10408398.2024.2442539
Jing Zhou, Yaolin Ren, Jie Yu, Yuan Zeng, Jing Ren, Yifan Wu, Qian Zhang, Xinhua Xiao

The early intrauterine environment of mothers during pregnancy significantly affects the metabolic health of their offspring. Existing studies suggest that poor maternal nutrition during pregnancy increases the risk of obesity or diabetes in offspring, so it is highly important to intervene during pregnancy to prevent metabolic disorders in mothers and their offspring. Polyphenols with anti-inflammatory and antioxidant properties are found in many foods and have protective effects on obesity, diabetes, cancer, and cardiovascular disease. Furthermore, recent evidence indicates that maternal dietary polyphenols could be a potential therapy for improving pregnancy outcomes and offspring metabolism. In this review, we discuss the studies and mechanisms of different kinds of maternal dietary polyphenols during pregnancy and lactation in improving the metabolism of offspring, analyze the limitations of the current studies, and propose possible directions of further research, which provide new ideas and directions for reducing metabolic diseases in offspring.

母亲怀孕期间的早期宫内环境显著影响其后代的代谢健康。现有研究表明,孕期孕产妇营养不良会增加后代肥胖或糖尿病的风险,因此在孕期进行干预以预防母亲及其后代的代谢紊乱非常重要。具有抗炎和抗氧化特性的多酚存在于许多食物中,对肥胖、糖尿病、癌症和心血管疾病有保护作用。此外,最近的证据表明,母亲饮食中的多酚可能是改善妊娠结局和后代代谢的潜在疗法。本文综述了孕期和哺乳期不同种类的母体膳食多酚在改善子代代谢中的研究及其作用机制,分析了目前研究的局限性,并提出了可能的进一步研究方向,为减少子代代谢性疾病提供新的思路和方向。
{"title":"The effect of maternal dietary polyphenol consumption on offspring metabolism.","authors":"Jing Zhou, Yaolin Ren, Jie Yu, Yuan Zeng, Jing Ren, Yifan Wu, Qian Zhang, Xinhua Xiao","doi":"10.1080/10408398.2024.2442539","DOIUrl":"https://doi.org/10.1080/10408398.2024.2442539","url":null,"abstract":"<p><p>The early intrauterine environment of mothers during pregnancy significantly affects the metabolic health of their offspring. Existing studies suggest that poor maternal nutrition during pregnancy increases the risk of obesity or diabetes in offspring, so it is highly important to intervene during pregnancy to prevent metabolic disorders in mothers and their offspring. Polyphenols with anti-inflammatory and antioxidant properties are found in many foods and have protective effects on obesity, diabetes, cancer, and cardiovascular disease. Furthermore, recent evidence indicates that maternal dietary polyphenols could be a potential therapy for improving pregnancy outcomes and offspring metabolism. In this review, we discuss the studies and mechanisms of different kinds of maternal dietary polyphenols during pregnancy and lactation in improving the metabolism of offspring, analyze the limitations of the current studies, and propose possible directions of further research, which provide new ideas and directions for reducing metabolic diseases in offspring.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"1-18"},"PeriodicalIF":7.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of dietary polyphenol administration as assessed by hormonal, glycolipid metabolism, inflammation and oxidative stress parameters in patients with PCOS: a meta-analysis and systematic review. 通过激素、糖脂代谢、炎症和氧化应激参数评估多囊卵巢综合征患者膳食多酚给药的有效性和安全性:荟萃分析和系统评价
IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-12-16 DOI: 10.1080/10408398.2024.2440063
Xian Jian, Chen Shi, Tongtong Xu, Boya Liu, Liyuan Zhou, Lili Jiang, Kuiran Liu
<p><strong>Background: </strong>The current knowledge about the efficacy and safety of dietary polyphenol administration in patients with polycystic ovarian syndrome (PCOS) is divergent.</p><p><strong>Objective: </strong>To evaluate the pooled efficacy and safety of dietary polyphenol administration in the treatment of patients with PCOS.</p><p><strong>Methods: </strong>The pubmed, Embase, Scopus, Cochrane Library, and Web of Science databases were searched for randomized controlled trials (RCTs) of dietary polyphenol administration for the treatment of PCOS. English-language RCTs involving adults with PCOS were thoroughly searched in electronic databases from the time of their establishment to May 2024. Random-effects models were used because heterogeneity was derived from differences in intervention materials and study duration, among other confounding factors. The effect sizes of the outcomes in the pooled analysis are expressed as weighted mean differences (WMDs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A total of 15 RCTs involving 934 patients were finally included. Compared with control treatments, dietary polyphenol administration significantly reduced luteinizing hormone (LH) (WMD: -0.85, 95% CI [-1.32 to -0.38], <i>p</i> = 0.00), and prolactin levels (WMD: -3.73, 95% CI [-6.73 to -0.74], <i>p</i> = 0.01). Dietary polyphenol administration significantly reduced insulin levels (WMD: -0.85, 95% CI [-1.32 to -0.38], <i>p</i> = 0.00). Regarding lipid metabolism, dietary polyphenol administration only reduced triglyceride levels (WMD: -8.96, 95% CI [-16.44 to -1.49], <i>p</i> = 0.02). Malondialdehyde (MDA) (WMD: -0.65, 95% CI [-0.68 to -0.62], <i>p</i> = 0.00), tumor necrosis factor (TNF-α) (WMD: -1.39, 95% CI [-2.41 to -0.37], <i>p</i> = 0.01) concentrations were significantly reduced by dietary polyphenol administration. None of the interventions significantly affected weight, body mass index (BMI), waist circumference (WC), homeostatic model-insulin resistance (HOMA-IR), fasting blood sugar (FBS), glycated hemoglobin (HBA1c), follicle-stimulating hormone (FSH), testosterone (T), dehydroepiandrosterone (DHEA), estradiol (E2), anti-Müllerian hormone (AMH), quantitative insulin-sensitivity check index (QUICKI), sex hormone-binding globulin (SHBG), total antioxidant capacity (TAC), C-peptide, C-reactive protein (CRP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, cholesterol/HDL, acne score, thyroid-stimulating hormone (TSH), aspartate aminotransferase (AST), alanine aminotransferase (ALT) or alkaline phosphatase (ALP).</p><p><strong>Conclusion: </strong>Dietary polyphenol administration was efficacious in patients with PCOS in our study. This review might provide new insight into the treatment of patients with PCOS and the potential of daily polyphenol supplementation in patients with PCOS. Nevertheless, these results must be interpreted carefully as a result of the heterogeneity and ris
背景:目前关于多囊卵巢综合征(PCOS)患者膳食多酚的疗效和安全性的认识存在分歧。目的:评价膳食多酚治疗多囊卵巢综合征的综合疗效和安全性。方法:检索pubmed、Embase、Scopus、Cochrane Library和Web of Science数据库,检索膳食多酚治疗PCOS的随机对照试验(rct)。对涉及成人多囊卵巢综合征的英语随机对照试验从建立之日起至2024年5月在电子数据库中进行全面检索。使用随机效应模型是因为异质性来源于干预材料和研究持续时间的差异,以及其他混杂因素。合并分析结果的效应量用加权平均差(wmd)和95%置信区间(ci)表示。结果:最终纳入15项rct,共934例患者。与对照组相比,饲粮多酚处理显著降低了黄体生成素(LH) (WMD: -0.85, 95% CI [-1.32 ~ -0.38], p = 0.00)和催乳素水平(WMD: -3.73, 95% CI [-6.73 ~ -0.74], p = 0.01)。膳食多酚可显著降低胰岛素水平(WMD: -0.85, 95% CI [-1.32 ~ -0.38], p = 0.00)。在脂质代谢方面,膳食多酚只降低了甘油三酯水平(WMD: -8.96, 95% CI[-16.44至-1.49],p = 0.02)。多酚组丙二醛(MDA) (WMD: -0.65, 95% CI [-0.68 ~ -0.62], p = 0.00)、肿瘤坏死因子(TNF-α) (WMD: -1.39, 95% CI [-2.41 ~ -0.37], p = 0.01)浓度显著降低。所有干预措施均未显著影响体重、体重指数(BMI)、腰围(WC)、稳态模型胰岛素抵抗(HOMA-IR)、空腹血糖(FBS)、糖化血红蛋白(HBA1c)、促卵泡激素(FSH)、睾酮(T)、脱氢表雄酮(DHEA)、雌二醇(E2)、抗勒氏激素(AMH)、胰岛素定量敏感性检查指数(QUICKI)、性激素结合球蛋白(SHBG)、总抗氧化能力(TAC)、c肽、c反应蛋白(CRP)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、胆固醇、胆固醇/HDL、痤疮评分、促甲状腺激素(TSH)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)或碱性磷酸酶(ALP)。结论:膳食多酚治疗多囊卵巢综合征是有效的。这一综述可能为多囊卵巢综合征患者的治疗和多囊卵巢综合征患者每日补充多酚的潜力提供新的见解。然而,由于研究的异质性和偏倚风险,这些结果必须仔细解释,我们期望将来会进行更多高质量的随机对照试验来评估膳食多酚给药对PCOS患者的疗效和安全性。系统评价注册:CRD42024498494。
{"title":"Efficacy and safety of dietary polyphenol administration as assessed by hormonal, glycolipid metabolism, inflammation and oxidative stress parameters in patients with PCOS: a meta-analysis and systematic review.","authors":"Xian Jian, Chen Shi, Tongtong Xu, Boya Liu, Liyuan Zhou, Lili Jiang, Kuiran Liu","doi":"10.1080/10408398.2024.2440063","DOIUrl":"https://doi.org/10.1080/10408398.2024.2440063","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The current knowledge about the efficacy and safety of dietary polyphenol administration in patients with polycystic ovarian syndrome (PCOS) is divergent.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the pooled efficacy and safety of dietary polyphenol administration in the treatment of patients with PCOS.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The pubmed, Embase, Scopus, Cochrane Library, and Web of Science databases were searched for randomized controlled trials (RCTs) of dietary polyphenol administration for the treatment of PCOS. English-language RCTs involving adults with PCOS were thoroughly searched in electronic databases from the time of their establishment to May 2024. Random-effects models were used because heterogeneity was derived from differences in intervention materials and study duration, among other confounding factors. The effect sizes of the outcomes in the pooled analysis are expressed as weighted mean differences (WMDs) and 95% confidence intervals (CIs).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 15 RCTs involving 934 patients were finally included. Compared with control treatments, dietary polyphenol administration significantly reduced luteinizing hormone (LH) (WMD: -0.85, 95% CI [-1.32 to -0.38], &lt;i&gt;p&lt;/i&gt; = 0.00), and prolactin levels (WMD: -3.73, 95% CI [-6.73 to -0.74], &lt;i&gt;p&lt;/i&gt; = 0.01). Dietary polyphenol administration significantly reduced insulin levels (WMD: -0.85, 95% CI [-1.32 to -0.38], &lt;i&gt;p&lt;/i&gt; = 0.00). Regarding lipid metabolism, dietary polyphenol administration only reduced triglyceride levels (WMD: -8.96, 95% CI [-16.44 to -1.49], &lt;i&gt;p&lt;/i&gt; = 0.02). Malondialdehyde (MDA) (WMD: -0.65, 95% CI [-0.68 to -0.62], &lt;i&gt;p&lt;/i&gt; = 0.00), tumor necrosis factor (TNF-α) (WMD: -1.39, 95% CI [-2.41 to -0.37], &lt;i&gt;p&lt;/i&gt; = 0.01) concentrations were significantly reduced by dietary polyphenol administration. None of the interventions significantly affected weight, body mass index (BMI), waist circumference (WC), homeostatic model-insulin resistance (HOMA-IR), fasting blood sugar (FBS), glycated hemoglobin (HBA1c), follicle-stimulating hormone (FSH), testosterone (T), dehydroepiandrosterone (DHEA), estradiol (E2), anti-Müllerian hormone (AMH), quantitative insulin-sensitivity check index (QUICKI), sex hormone-binding globulin (SHBG), total antioxidant capacity (TAC), C-peptide, C-reactive protein (CRP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, cholesterol/HDL, acne score, thyroid-stimulating hormone (TSH), aspartate aminotransferase (AST), alanine aminotransferase (ALT) or alkaline phosphatase (ALP).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Dietary polyphenol administration was efficacious in patients with PCOS in our study. This review might provide new insight into the treatment of patients with PCOS and the potential of daily polyphenol supplementation in patients with PCOS. Nevertheless, these results must be interpreted carefully as a result of the heterogeneity and ris","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"1-25"},"PeriodicalIF":7.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure and degradation dynamics of dietary pectin. 日粮果胶的结构与降解动力学。
IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-12-16 DOI: 10.1080/10408398.2024.2437573
Ecem Yüksel, Remco Kort, Alphons G J Voragen

Pectin, a complex dietary fiber, constitutes a key structural component of the cell walls of numerous edible plant products. It is resistant to digestion by human enzymes and undergoes depolymerization and saccharification in the gastrointestinal tract through the action of carbohydrate-active enzymes (CAZymes) produced by gut microbiota. This enzymatic breakdown generates intermediate structural fragments, which are subsequently converted into pectin oligosaccharides (POS) and monosaccharides. POS exhibit prebiotic properties and have demonstrated potential health benefits, including anti-carcinogenic effects, mucoadhesive capabilities, and the promotion of beneficial gut bacterial growth. However, the current understanding of the molecular structure of pectin and its degradation dynamics remains fragmented within the literature, impeding progress in dietary fiber intervention research and the development of personalized nutrition approaches. This review aims to provide a comprehensive overview of the structural features of pectin and the intricate breakdown mechanisms orchestrated by CAZymes. It underscores the complex architecture of pectin that influences its breakdown dynamics and specifies the enzymatic requirements for the cleavage of its diverse structural components. These insights complement our accompanying review on the structure-function relationships between pectin and the human gut microbiota, previously published in this journal.

果胶是一种复杂的膳食纤维,是许多可食用植物产品细胞壁的关键结构成分。它抵抗人体酶的消化,并通过肠道菌群产生的碳水化合物活性酶(CAZymes)的作用在胃肠道中解聚和糖化。这种酶分解产生中间结构片段,随后转化为果胶寡糖(POS)和单糖。POS具有益生元特性,并已证明具有潜在的健康益处,包括抗癌作用、黏附能力和促进有益肠道细菌生长。然而,目前对果胶分子结构及其降解动力学的理解在文献中仍然是碎片化的,阻碍了膳食纤维干预研究和个性化营养方法的发展。本文旨在全面介绍果胶的结构特征和CAZymes介导的复杂分解机制。它强调了果胶的复杂结构,影响其分解动力学,并规定了其多种结构成分的切割酶的要求。这些见解补充了我们之前在该杂志上发表的关于果胶和人类肠道微生物群之间结构-功能关系的评论。
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引用次数: 0
Conversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acids: bioavailability and dietary regulation. α-亚麻酸转化为 n-3 长链多不饱和脂肪酸:生物利用率和膳食调节。
IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-12-16 DOI: 10.1080/10408398.2024.2442064
Lei Wang, Chen Cheng, Xiao Yu, Liang Guo, Xia Wan, Jiqu Xu, Xia Xiang, Jing Yang, Jingxuan Kang, Qianchun Deng

N-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are essential for physiological requirements and disease prevention throughout life but are not adequately consumed worldwide. Dietary supplementation with plant-derived α-linolenic acid (ALA) has the potential to rebalance the fatty acid profile and enhance health benefits but faces challenges such as high β-oxidation consumption, low hepatic conversion efficiency, and high oxidative susceptibility under stress. This review focuses on the metabolic fate and potential regulatory targets of ALA-containing lipids in vivo, specifically the pathway from the gastrointestinal tract to the lymph, blood circulation, and liver. We propose a hypothesis that positively regulates the conversion of ALA into n-3 LCPUFAs based on the model of "fast" or "slow" absorption, transport, and hepatic metabolic fate. Furthermore, the potential effects of dietary nutrients on the metabolic conversion of ALA into n-3 LCPUFAs are discussed. The conversion of ALA is differentially regulated by structured lipids, phospholipids, other lipids, carbohydrates, specific proteins, amino acids, polyphenols, vitamins, and minerals. Future research should focus on designing a steady-state and precise delivery system for ALA, coupled with specific nutrients or phytochemicals, to effectively improve its metabolic conversion and ultimately achieve synergistic regulation of nutrition and health effects.

N-3长链多不饱和脂肪酸(N-3 LCPUFAs)是生命中生理需求和疾病预防所必需的,但在世界范围内并没有得到充分的消耗。膳食中补充植物源性α-亚麻酸(ALA)有可能重新平衡脂肪酸结构并增强健康益处,但面临β-氧化消耗高、肝脏转化效率低和应激下氧化敏感性高等挑战。本文综述了含ala的脂质在体内的代谢命运和潜在的调节靶点,特别是从胃肠道到淋巴、血液循环和肝脏的途径。基于“快”或“慢”的吸收、运输和肝脏代谢命运模型,我们提出了一个正向调节ALA转化为n-3 LCPUFAs的假设。此外,还讨论了膳食营养素对ALA代谢转化为n-3 LCPUFAs的潜在影响。ALA的转化受到结构性脂质、磷脂、其他脂质、碳水化合物、特定蛋白质、氨基酸、多酚、维生素和矿物质的不同调节。未来的研究应着眼于设计一种稳定、精确的ALA输送系统,并与特定的营养素或植物化学物质结合,有效地提高其代谢转化,最终实现营养与健康效应的协同调节。
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Critical reviews in food science and nutrition
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