Pub Date : 2020-06-01DOI: 10.1007/s12281-020-00382-7
J. Serrano, A. Dorado, Y. Chacón, N. Fortuny, R. Valdez
{"title":"Mycetomas in the Endemic Area of Argentina","authors":"J. Serrano, A. Dorado, Y. Chacón, N. Fortuny, R. Valdez","doi":"10.1007/s12281-020-00382-7","DOIUrl":"https://doi.org/10.1007/s12281-020-00382-7","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"115-119"},"PeriodicalIF":1.4,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00382-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43208880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01Epub Date: 2020-03-26DOI: 10.1007/s12281-020-00379-2
Alison R Novak, Mary E Bradley, Tyree H Kiser, Scott W Mueller
Purpose of review: This review summarizes current treatment options for echinocandin-resistant Candida spp. (ERC) and azole-resistant Aspergillus fumigatus (ARAF), emphasizing recent in vitro/in vivo data, clinical reports, and consensus statements.
Recent findings: Advances in ERC and ARAF treatment are limited to specific antifungal combinations and dose optimization but remain reliant on amphotericin products. Although novel antifungals may provide breakthroughs in the treatment of resistant fungi, these agents are not yet available. Early identification and appropriate treatment remain a paramount, albeit elusive, task.
Summary: When either ERC or ARAF are suspected or proven, amphotericin products remain the cornerstone of initial therapy. For ERC, azoles are de-escalation options for susceptible isolates in stable patients to avoid amphotericin toxicities. Although combination echinocandin with high-dose salvage posaconazole or isavuconazole may be attempted in ARAF, it requires careful consideration following patient stabilization. Future research defining optimal therapies and early identification of ERC and ARAF is of extreme importance.
{"title":"Azole-resistant Aspergillus and Echinocandin-resistant Candida - What are the treatment options?","authors":"Alison R Novak, Mary E Bradley, Tyree H Kiser, Scott W Mueller","doi":"10.1007/s12281-020-00379-2","DOIUrl":"https://doi.org/10.1007/s12281-020-00379-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review summarizes current treatment options for echinocandin-resistant <i>Candida</i> spp. (ERC) and azole-resistant <i>Aspergillus fumigatus</i> (ARAF), emphasizing recent <i>in vitro/in vivo</i> data, clinical reports, and consensus statements.</p><p><strong>Recent findings: </strong>Advances in ERC and ARAF treatment are limited to specific antifungal combinations and dose optimization but remain reliant on amphotericin products. Although novel antifungals may provide breakthroughs in the treatment of resistant fungi, these agents are not yet available. Early identification and appropriate treatment remain a paramount, albeit elusive, task.</p><p><strong>Summary: </strong>When either ERC or ARAF are suspected or proven, amphotericin products remain the cornerstone of initial therapy. For ERC, azoles are de-escalation options for susceptible isolates in stable patients to avoid amphotericin toxicities. Although combination echinocandin with high-dose salvage posaconazole or isavuconazole may be attempted in ARAF, it requires careful consideration following patient stabilization. Future research defining optimal therapies and early identification of ERC and ARAF is of extreme importance.</p>","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 2","pages":"141-152"},"PeriodicalIF":1.4,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00379-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38189731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-21DOI: 10.1007/s12281-020-00390-7
Kayla R. Stover, J. Cleary
{"title":"Antifungal Penetration and Distribution into Organs and Tissue","authors":"Kayla R. Stover, J. Cleary","doi":"10.1007/s12281-020-00390-7","DOIUrl":"https://doi.org/10.1007/s12281-020-00390-7","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2020-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00390-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45930410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-19DOI: 10.1007/s12281-020-00391-6
J. Cota, S. Giancola, Taylor M. Benavides, N. Wiederhold
{"title":"Implications of Evolving and Emerging Pharmacokinetic-Pharmacodynamic Research for Triazoles and Echinocandins","authors":"J. Cota, S. Giancola, Taylor M. Benavides, N. Wiederhold","doi":"10.1007/s12281-020-00391-6","DOIUrl":"https://doi.org/10.1007/s12281-020-00391-6","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"1 1","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2020-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00391-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44992411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-16DOI: 10.1007/s12281-020-00383-6
L. Vanderbeke, E. Wijngaerden, J. Maertens, J. Wauters, K. Lagrou
{"title":"Diagnosis of Invasive Aspergillosis in Intensive Care Unit Patients","authors":"L. Vanderbeke, E. Wijngaerden, J. Maertens, J. Wauters, K. Lagrou","doi":"10.1007/s12281-020-00383-6","DOIUrl":"https://doi.org/10.1007/s12281-020-00383-6","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"166-173"},"PeriodicalIF":1.4,"publicationDate":"2020-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00383-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42624622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-16DOI: 10.1007/s12281-020-00388-1
X. Tan, K. Baugh, Z. Bulman, E. Wenzler
{"title":"Review of the Current Management of Urinary Tract Infections due to Fluconazole-Resistant and Non-Albicans Candida Species","authors":"X. Tan, K. Baugh, Z. Bulman, E. Wenzler","doi":"10.1007/s12281-020-00388-1","DOIUrl":"https://doi.org/10.1007/s12281-020-00388-1","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"268 - 278"},"PeriodicalIF":1.4,"publicationDate":"2020-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00388-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42429582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-07DOI: 10.1007/s12281-020-00386-3
C. Gustafson, M. Koslosky, J. Leslie, C. Walczak
{"title":"Antifungal and Oral Anticancer Therapy Drug Interactions","authors":"C. Gustafson, M. Koslosky, J. Leslie, C. Walczak","doi":"10.1007/s12281-020-00386-3","DOIUrl":"https://doi.org/10.1007/s12281-020-00386-3","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"130-140"},"PeriodicalIF":1.4,"publicationDate":"2020-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00386-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48384577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.1007/s12281-020-00387-2
K. Goodlet, K. Spadafora, R. Walia, M. Nailor
{"title":"Updates in the Treatment of Breakthrough Mold Infections","authors":"K. Goodlet, K. Spadafora, R. Walia, M. Nailor","doi":"10.1007/s12281-020-00387-2","DOIUrl":"https://doi.org/10.1007/s12281-020-00387-2","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"153-165"},"PeriodicalIF":1.4,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00387-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44470764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-11DOI: 10.1007/s12281-020-00384-5
S. Challa
{"title":"Invasive Fungal Infections of the Central Nervous System in Immune-Competent Hosts","authors":"S. Challa","doi":"10.1007/s12281-020-00384-5","DOIUrl":"https://doi.org/10.1007/s12281-020-00384-5","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"174-185"},"PeriodicalIF":1.4,"publicationDate":"2020-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00384-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44918577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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