Pub Date : 2020-06-20DOI: 10.1007/s12281-020-00399-y
Sara J. Gore, G. Forrest
{"title":"Cryptococcosis in Liver Transplant Candidates and Recipients","authors":"Sara J. Gore, G. Forrest","doi":"10.1007/s12281-020-00399-y","DOIUrl":"https://doi.org/10.1007/s12281-020-00399-y","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2020-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00399-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48400210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-17DOI: 10.1007/s12281-020-00398-z
Ó. Martínez, J. Jarrah, S. Revankar
{"title":"Invasive Phaeohyphomycosis in Immunocompetent Hosts","authors":"Ó. Martínez, J. Jarrah, S. Revankar","doi":"10.1007/s12281-020-00398-z","DOIUrl":"https://doi.org/10.1007/s12281-020-00398-z","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":" ","pages":"1-6"},"PeriodicalIF":1.4,"publicationDate":"2020-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00398-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44285450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-11DOI: 10.1007/s12281-020-00394-3
Tirado-Sánchez Andrés, Bonifaz Alexandro
{"title":"Candida Onychomycosis: an Old Problem in Modern Times","authors":"Tirado-Sánchez Andrés, Bonifaz Alexandro","doi":"10.1007/s12281-020-00394-3","DOIUrl":"https://doi.org/10.1007/s12281-020-00394-3","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"209 - 216"},"PeriodicalIF":1.4,"publicationDate":"2020-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00394-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46321074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01Epub Date: 2020-04-16DOI: 10.1007/s12281-020-00385-4
David R Tribble, Anuradha Ganesan, Carlos J Rodriguez
Purpose of review: This review highlights research from the past five years on combat trauma-related invasive fungal wound infections (IFIs) with a focus on risk stratification to aid patient management, microbiology, and diagnostics.
Recent findings: A revised classification scheme stratifies wounds into three risk groups: IFI, High Suspicion of IFI, and Low Suspicion of IFI. This stratification is based on persistence of wound necrosis and laboratory fungal evidence, presence of signs/symptoms of deep soft-tissue infections, and the need for antifungals. Use of this classification could allow for prioritization of antifungal therapy. Further, IFIs delay wound healing, particularly when caused by fungi of the order Mucorales. Lastly, molecular sequencing offers promising and complimentary results to the gold standard histopathology.
Summary: Optimal management of combat-related IFIs depends on early tissue-based diagnosis with aggressive surgical debridement and concomitant dual antifungal therapy. Further research on clinical decision support tools and rapid diagnostics are needed.
{"title":"Combat trauma-related invasive fungal wound infections.","authors":"David R Tribble, Anuradha Ganesan, Carlos J Rodriguez","doi":"10.1007/s12281-020-00385-4","DOIUrl":"10.1007/s12281-020-00385-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review highlights research from the past five years on combat trauma-related invasive fungal wound infections (IFIs) with a focus on risk stratification to aid patient management, microbiology, and diagnostics.</p><p><strong>Recent findings: </strong>A revised classification scheme stratifies wounds into three risk groups: IFI, High Suspicion of IFI, and Low Suspicion of IFI. This stratification is based on persistence of wound necrosis and laboratory fungal evidence, presence of signs/symptoms of deep soft-tissue infections, and the need for antifungals. Use of this classification could allow for prioritization of antifungal therapy. Further, IFIs delay wound healing, particularly when caused by fungi of the order Mucorales. Lastly, molecular sequencing offers promising and complimentary results to the gold standard histopathology.</p><p><strong>Summary: </strong>Optimal management of combat-related IFIs depends on early tissue-based diagnosis with aggressive surgical debridement and concomitant dual antifungal therapy. Further research on clinical decision support tools and rapid diagnostics are needed.</p>","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 2","pages":"186-196"},"PeriodicalIF":2.3,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360332/pdf/nihms-1585309.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38160167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.1007/s12281-020-00382-7
J. Serrano, A. Dorado, Y. Chacón, N. Fortuny, R. Valdez
{"title":"Mycetomas in the Endemic Area of Argentina","authors":"J. Serrano, A. Dorado, Y. Chacón, N. Fortuny, R. Valdez","doi":"10.1007/s12281-020-00382-7","DOIUrl":"https://doi.org/10.1007/s12281-020-00382-7","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"115-119"},"PeriodicalIF":1.4,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00382-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43208880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01Epub Date: 2020-03-26DOI: 10.1007/s12281-020-00379-2
Alison R Novak, Mary E Bradley, Tyree H Kiser, Scott W Mueller
Purpose of review: This review summarizes current treatment options for echinocandin-resistant Candida spp. (ERC) and azole-resistant Aspergillus fumigatus (ARAF), emphasizing recent in vitro/in vivo data, clinical reports, and consensus statements.
Recent findings: Advances in ERC and ARAF treatment are limited to specific antifungal combinations and dose optimization but remain reliant on amphotericin products. Although novel antifungals may provide breakthroughs in the treatment of resistant fungi, these agents are not yet available. Early identification and appropriate treatment remain a paramount, albeit elusive, task.
Summary: When either ERC or ARAF are suspected or proven, amphotericin products remain the cornerstone of initial therapy. For ERC, azoles are de-escalation options for susceptible isolates in stable patients to avoid amphotericin toxicities. Although combination echinocandin with high-dose salvage posaconazole or isavuconazole may be attempted in ARAF, it requires careful consideration following patient stabilization. Future research defining optimal therapies and early identification of ERC and ARAF is of extreme importance.
{"title":"Azole-resistant Aspergillus and Echinocandin-resistant Candida - What are the treatment options?","authors":"Alison R Novak, Mary E Bradley, Tyree H Kiser, Scott W Mueller","doi":"10.1007/s12281-020-00379-2","DOIUrl":"https://doi.org/10.1007/s12281-020-00379-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review summarizes current treatment options for echinocandin-resistant <i>Candida</i> spp. (ERC) and azole-resistant <i>Aspergillus fumigatus</i> (ARAF), emphasizing recent <i>in vitro/in vivo</i> data, clinical reports, and consensus statements.</p><p><strong>Recent findings: </strong>Advances in ERC and ARAF treatment are limited to specific antifungal combinations and dose optimization but remain reliant on amphotericin products. Although novel antifungals may provide breakthroughs in the treatment of resistant fungi, these agents are not yet available. Early identification and appropriate treatment remain a paramount, albeit elusive, task.</p><p><strong>Summary: </strong>When either ERC or ARAF are suspected or proven, amphotericin products remain the cornerstone of initial therapy. For ERC, azoles are de-escalation options for susceptible isolates in stable patients to avoid amphotericin toxicities. Although combination echinocandin with high-dose salvage posaconazole or isavuconazole may be attempted in ARAF, it requires careful consideration following patient stabilization. Future research defining optimal therapies and early identification of ERC and ARAF is of extreme importance.</p>","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 2","pages":"141-152"},"PeriodicalIF":1.4,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00379-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38189731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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