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Sindrome delle apnee ostruttive del sonno 睡眠呼吸暂停障碍综合症
Pub Date : 1900-01-01 DOI: 10.7362/2240-2594.060.2012
M. Fabiani
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引用次数: 7
Electromagnetic fields and autoimmune diseases 电磁场和自身免疫性疾病
Pub Date : 1900-01-01 DOI: 10.11138/PER/2014.3.2.079
P. Boscolo
Introduction: experimental studies demonstrated that electromagnetic fields (EMFs) modify ion calcium fluxes in the membranes of blood mononuclear cells and induce changes in metabolism and surface marker expression. There is also evidence of autoimmune diseases in subjects with genetic predisposition, following exposure to physical, chemical or biological noxious agents or perception of stressful situations. The aim of this systematic review is to evaluate the effects of electromagnetic fields (EMFs) on onset and progression of autoimmune diseases. Materials and Methods: all papers published in scientific journal from 1979 to 2013 were examined for inclusion in the systematic review. The research was conducted using the following key-words: electromagnetic fields, immune response, autoimmunity, Systemic Lupus Erythematosus. 37 studies were included in this article. Results: there is clear evidence that exposure to EMFs produced by radiotelevision broadcasting stations, radars, or electricity induces changes (within the physiological range) in number and percentage of circulating immune cells as well as in the immune response. Experimental studies on rats demonstrated that exposure to electricity induces metabolic effects similar to those of stress. Women resident near high power lines showed reduced melatonin production as in workers performing stressful night shifts. Employees with prolonged conversation time on mobile phone showed lower levels of serum TSH (index of increased thyroid metabolism) as in situations of stress. Discussion: it is demonstrated that there is absorption of energy in organisms exposed to EMFs; the effects of the EMFs (more elevated on the immune and nervous systems) are similar to those induced by stress stimulations. We suggest that the adaptation of tissues to the EMFs, in genetically predisposed subjects, may stimulate the onset and progression of autoimmune diseases.
导论:实验研究表明,电磁场(emf)改变血单核细胞膜上的离子钙通量,诱导代谢和表面标志物表达的变化。也有证据表明,在暴露于物理、化学或生物有害物质或感知压力情况后,具有遗传易感性的受试者会患上自身免疫性疾病。本系统综述的目的是评估电磁场(emf)对自身免疫性疾病的发生和发展的影响。材料与方法:将1979 - 2013年发表在科学期刊上的所有论文纳入系统评价。本研究以电磁场、免疫反应、自身免疫、系统性红斑狼疮为关键词,共纳入37项研究。结果:有明确的证据表明,暴露于无线电电视广播站、雷达或电产生的电磁场会引起循环免疫细胞的数量和百分比以及免疫反应的变化(在生理范围内)。对老鼠的实验研究表明,暴露在电中会引起与压力相似的代谢效应。住在高压电线附近的女性褪黑素分泌减少,与夜班工人一样。与手机通话时间较长的员工在压力情况下血清TSH(甲状腺代谢增加指数)水平较低。讨论:已经证明,暴露于电磁场的生物体有能量吸收;电磁场的影响(对免疫和神经系统的影响更大)与压力刺激引起的影响相似。我们认为,在遗传易感的受试者中,组织对电磁场的适应可能会刺激自身免疫性疾病的发生和进展。
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引用次数: 0
New anathemas: conscientious objection and freedom to access drugs in emergency contraception 新的诅咒:出于良心拒服兵役和获得紧急避孕药物的自由
Pub Date : 1900-01-01 DOI: 10.11138/PR/2012.1.1.001
Costantino Cialella
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引用次数: 1
Case report of an occupational electrocution fatality: histopathological, medicolegal, work safety and insurance implications 职业性触电死亡病例报告:组织病理学、医学、工作安全和保险意义
Pub Date : 1900-01-01 DOI: 10.11138/PER/2017.6.2.012
M. Sammicheli
When the skin comes to contact with power lines or non-insulated electrical instruments, we have an effect called electrocution. This often occurs in
当皮肤接触到电线或非绝缘的电气仪器时,我们会产生一种叫做触电的效应。这种情况经常发生在
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引用次数: 1
Enterobacter cloacae ventriculitis successfully treated with cerebrospinal system irrigation and intraventricular colistin, preliminary report 脑脊髓系统灌洗和脑室内粘菌素治疗阴沟肠杆菌脑室炎成功,初步报告
Pub Date : 1900-01-01 DOI: 10.11138/PER/2017.6.2.031
C. Pizzoni
Ventriculitis is difficult to treat and can lead to serious sequelae, a long course of treatment and hospitalization. We report a case of enterobacter cloacae ventriculitis and progressive hydrocephalus successfully treated by neuroendoscopic intraventricular irrigation followed by ventricular and subarachnoid space (cerebrospinal system) irrigation with Ringer’s lactate solution. Despite surgical intervention has not been established as a first-choice treatment for ventriculitis, neuroendoscopic surgery followed cerebrospinal system irrigation and intraventricular colistin, appears effective for the management of ventriculitis
脑室炎难以治疗,可导致严重的后遗症、长期治疗和住院。我们报告一例阴沟肠杆菌脑室炎和进行性脑积水成功治疗神经内窥镜脑室灌洗后脑室和蛛网膜下腔(脑脊液)灌洗乳酸林格氏溶液。尽管手术干预尚未被确定为脑室炎的首选治疗方法,但神经内窥镜手术后脑脊液系统冲洗和脑室内粘菌素似乎对脑室炎的治疗有效
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引用次数: 0
Recent advances in pathophysiology of biliary tree: influence of sex hormones in cholangiocyte growth 胆道病理生理研究进展:性激素对胆管细胞生长的影响
Pub Date : 1900-01-01 DOI: 10.11138/PR/2012.1.2.073
R. Mancinelli
Cholangiocytes are epithelial cells that line the biliary tree (1). The intrahepatic biliary tree is characterized by interconnected ducts which starts with canals of Hering, continues into intrahepatic ducts of increasing diameter to end at the level of the extrahepatic bile ducts (2). These cells play a key role in the ductal secretion of water and bicarbonate during the process of bile formation. These cells are also the target in several chronic cholestatic liver diseases (termed cholangiopathies), including primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), polycystic liver disease (PCLD) and cholangiocarcinoma (CCA) (3, 4). During these conditions, the balance between proliferation/loss of cholangiocytes is lost with critical effect on the maintenance of biliary functions and intrahepatic bile ductal mass (3, 5, 6). A typical feature that occurs under specific experimental conditions, such as common bile duct ligation (BDL) (Fig.1). After BDL, there is biliary hyperplasia and secretin stimulated choleresis (a functional marker of cholangiocyte growth) (5). Cholangiocyte growth/apoptosis is regulated by several factors, including growth factors, cytokines, gastrointestinal and sex hormones, such as estrogens, prolactin, follicle-stimulating hormone (FSH), testosterone and progesterone (3, 7, 8, 9). The purpose of this review is to summarize the recent findings on the effects of sex hormones in cholangiocyte pathophysiology. To clarify the mechanisms of action of these substances will provide new potential strategies for the management of chronic liver diseases.
胆管细胞是排列在胆道树上的上皮细胞(1)。肝内胆道树的特征是相互连接的管道,从胆管开始,继续进入肝内胆管,直径不断增加,最终到达肝外胆管(2)。这些细胞在胆汁形成过程中,在胆管分泌水和碳酸氢盐中起关键作用。这些细胞也是几种慢性胆汁淤积性肝病(称为胆管病)的靶点,包括原发性硬化性胆管炎(PSC)、原发性胆汁性肝硬化(PBC)、多囊性肝病(PCLD)和胆管癌(CCA)(3,4)。在这些疾病中,胆管细胞增殖/损失之间的平衡被破坏,对胆道功能和肝内胆管肿块的维持产生关键影响(3,5)。6)在特定实验条件下出现的典型特征,如胆总管结扎(BDL)(图1)。胆管细胞的生长/凋亡受多种因素的调控,包括生长因子、细胞因子、胃肠激素和性激素,如雌激素、催乳素、促卵泡激素(FSH)、睾酮和孕酮(3,7,8,9)。本文就性激素在胆管细胞病理生理中的作用的最新研究进展进行综述。阐明这些物质的作用机制将为慢性肝病的治疗提供新的潜在策略。
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引用次数: 2
Medicolegal considerations on the concept of inability according to the law no 222/84 (INPS) and the law no 118/71 (Civil Invalidity): similarities, differences and operational practices in the medicolegal evaluation of oncological diseases 根据第222/84号法律(INPS)和第118/71号法律(民事无效)对无能概念的医学法律考虑:肿瘤疾病医学法律评估中的异同和操作做法
Pub Date : 1900-01-01 DOI: 10.11138/PER/2016.5.4.140
M. Sammicheli
Introduction: the law 222/1984, on which the INPS (Italian National Welfare Institute) social security concept is based and which sets the unfit-to-work person as the one who “is in the total and permanent inability to perform any work activity”, is compared with the similar concept in the Civil Invalidity, which sets the unfit-to-work person as the one who has lost the “general working
导言:以意大利国家福利协会(INPS)社会保障概念为基础的第222/1984号法律将不适合工作的人定为“完全和永久不能从事任何工作活动”的人,并将其与《民事无效法》中的类似概念进行比较,后者将不适合工作的人定为失去“一般工作能力”的人
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引用次数: 0
THE PRIMARY AND SECONDARY ENDOMETRIOSIS WITHIN ABDOMINAL WALL 腹壁内原发性和继发性子宫内膜异位症
Pub Date : 1900-01-01 DOI: 10.11138/PR/2013.2.1.001
R. Capoano, M. C. Tesori, E. Mastroluca, G. Lacroce, K. Llange, E. Gianfrancesco, C. Donello, Federica Lombardo
Background: Endometriosis is defined as the presence of functional endometrial glands and stroma outside the uterine cavity. It’s classified in a primary and a secondary form. The endometriosis is a common gynecological disease with a prevalence estimated between 8-15%, it usually occurs in women during the reproductive years, with the maximum incidence between 30 and 40 year old women. The primary endometriosis form of the rectus abdominis muscle includes lesions that are not a result of a previous surgical procedure. This is an exceptional occurrence and only 18 cases have been described in Literature from 1984 to 2004. The incidence of the secondary form has been estimated around 0,003%-4%.
背景:子宫内膜异位症被定义为子宫腔外存在功能性子宫内膜腺体和间质。它分为初级和次级形式。子宫内膜异位症是一种常见的妇科疾病,患病率估计在8-15%之间,通常发生在育龄妇女中,发病率最高的是30 - 40岁妇女。原发性子宫内膜异位症形式的腹直肌包括病变,不是以前的外科手术的结果。这是一种罕见的情况,从1984年到2004年,文献中只描述了18例。据估计,继发性的发病率约为0.003% -4%。
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引用次数: 0
Perceived stress and hepatic parameters 感知压力和肝脏参数
Pub Date : 1900-01-01 DOI: 10.11138/PER/2016.5.4.118
F. Tomei
Introduction: the aim of the study is to evaluate work-related subjective stress in a group of employees, of both sexes, operating in the healthcare and welfare, through the administration of a questionnaire (HSE “Indicator Tool”), specifically developed and officially validated, and to analyze any possible correlations between stress levels taken from the questionnaire scores and the concentrations of three main hepatic parameters
简介:本研究的目的是通过专门开发和正式验证的问卷(HSE“指标工具”)的管理,评估一组在医疗保健和福利领域工作的男女员工的工作相关主观压力,并分析从问卷得分中获得的压力水平与三个主要肝脏参数浓度之间可能存在的相关性
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引用次数: 0
Motor ability and visual-motor integration in children 儿童运动能力和视觉-运动整合
Pub Date : 1900-01-01 DOI: 10.11138/PR/2013.2.1.022
V. Baglioni
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引用次数: 1
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