Pub Date : 1900-01-01DOI: 10.11138/PER/2014.3.3.112
G. Palaia
Background: oral cancer has been associated with several risk factor, such as smoking, alcohol, irritants and irradiation. The presence of HPV in oral cancers suggests that HPV may play a similar role in transforming oral epithelia. Objectives: a significant association was appreciated between infection with human papillomavirus (HPV), squamous cell carcinoma and potentially malignant disorders of the oral cavity, such as leukoplakia, erythro-leukoplakia erythroplakia. This review will attempt to focus on relevant characteristics of HPV, analyze its role in oral cancer and discuss some emerging developments. Methods: from the critical analysis of the current literature, many studies evaluating different markers of exposure and viral activity in tumors were collected. Several studies have investigated the prevalence of HPV in these cancers, but the prevalence of HPV detection varies broadly, depending on the population, combination of sub-sites, typology of specimen and method of detection. Results: the majority of HPV-related cancers contain HPV DNA integrated into the host cell genome and express only two viral genes, E6 and E7, both of which encode oncoproteins. Data published in the literature have provided strong evidence that HPVs may be the cause of a defined subset of head and neck cancers and also an indicator of improved survival. Discussion: while the role of HPV infection in the onset of cervix cancer is now well established, there is little information on the prevalence, determinants and natural history of the infection in the oral mucosa, and further studies are needed to clarify the potential role of HPV in the onset of oral cancer.
{"title":"Papilloma virus and oral lesions. Infection and increased risk of potential malignant transformation. A systematic review","authors":"G. Palaia","doi":"10.11138/PER/2014.3.3.112","DOIUrl":"https://doi.org/10.11138/PER/2014.3.3.112","url":null,"abstract":"Background: oral cancer has been associated with several risk factor, such as smoking, alcohol, irritants and irradiation. The presence of HPV in oral cancers suggests that HPV may play a similar role in transforming oral epithelia. Objectives: a significant association was appreciated between infection with human papillomavirus (HPV), squamous cell carcinoma and potentially malignant disorders of the oral cavity, such as leukoplakia, erythro-leukoplakia erythroplakia. This review will attempt to focus on relevant characteristics of HPV, analyze its role in oral cancer and discuss some emerging developments. Methods: from the critical analysis of the current literature, many studies evaluating different markers of exposure and viral activity in tumors were collected. Several studies have investigated the prevalence of HPV in these cancers, but the prevalence of HPV detection varies broadly, depending on the population, combination of sub-sites, typology of specimen and method of detection. Results: the majority of HPV-related cancers contain HPV DNA integrated into the host cell genome and express only two viral genes, E6 and E7, both of which encode oncoproteins. Data published in the literature have provided strong evidence that HPVs may be the cause of a defined subset of head and neck cancers and also an indicator of improved survival. Discussion: while the role of HPV infection in the onset of cervix cancer is now well established, there is little information on the prevalence, determinants and natural history of the infection in the oral mucosa, and further studies are needed to clarify the potential role of HPV in the onset of oral cancer.","PeriodicalId":109386,"journal":{"name":"Prevention and Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131744966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.11138/PER/2016.5.2.050
S. Zoppis
Genetic analyses on bone remains in the field of human identification represent one of the most stimulating and complex challenges for forensic geneticists. In this work, preliminary results of the analysis of bone remains performed by the use of the commercial kit named PowerPlex® Fusion System (Promega Corporation, Madison, WI) are shown. Our study was conducted on 10 casework samples that came to our observation, for which the Prosecutor asked to perform genetic analyses to the purpose of either personal identification or the assessment of a parental relationship. Taking into account the analytical challenges already faced during the analyses previously performed using other commercial STRs kits, our attention was focused on 3 important variable factors that can determine the success or failure of the analyses: the age of the remains, the environmental conditions of storage and/or finding and finally, where known, the cause of death. The preliminary results of this study show that the possibility to obtain a genetic profile useful for identification purposes depends on the variables represented by age of the samples and environmental conditions of storage/finding, with a particular interest to the latter. This study shows, on the one hand, the importance of bone remains as an indisputable resource in cases of forensic interest, and on the other hand the issues related to the genetic analysis of these samples because of the frequent presence of chemical-physical factors responsible for DNA degradation and/or inhibition.
在人类身份鉴定领域，骨骸的遗传分析是法医遗传学家面临的最具挑战性和最复杂的挑战之一。在这项工作中，显示了使用名为PowerPlex®Fusion System (Promega Corporation, Madison, WI)的商业试剂盒进行骨残留物分析的初步结果。我们对我们观察到的10个个案样本进行了研究，检察官要求对这些样本进行遗传分析，以便进行个人鉴定或评估父母关系。考虑到之前使用其他商业STRs试剂盒进行分析时已经面临的分析挑战，我们的注意力集中在可以决定分析成功或失败的3个重要可变因素上:遗骸的年龄、储存和/或发现的环境条件，以及最后，在已知的情况下，死因。这项研究的初步结果表明，获得用于鉴定目的的遗传谱的可能性取决于样品年龄和储存/发现的环境条件所代表的变量，对后者特别感兴趣。这项研究表明，一方面，骨骼作为法医兴趣案例中无可争议的资源的重要性，另一方面，由于经常存在导致DNA降解和/或抑制的化学-物理因素，与这些样本的遗传分析相关的问题。
{"title":"Genetic analyses on bone remains with the PowerPlex Fusion System kit","authors":"S. Zoppis","doi":"10.11138/PER/2016.5.2.050","DOIUrl":"https://doi.org/10.11138/PER/2016.5.2.050","url":null,"abstract":"Genetic analyses on bone remains in the field of human identification represent one of the most stimulating and complex challenges for forensic geneticists. In this work, preliminary results of the analysis of bone remains performed by the use of the commercial kit named PowerPlex® Fusion System (Promega Corporation, Madison, WI) are shown. Our study was conducted on 10 casework samples that came to our observation, for which the Prosecutor asked to perform genetic analyses to the purpose of either personal identification or the assessment of a parental relationship. Taking into account the analytical challenges already faced during the analyses previously performed using other commercial STRs kits, our attention was focused on 3 important variable factors that can determine the success or failure of the analyses: the age of the remains, the environmental conditions of storage and/or finding and finally, where known, the cause of death. The preliminary results of this study show that the possibility to obtain a genetic profile useful for identification purposes depends on the variables represented by age of the samples and environmental conditions of storage/finding, with a particular interest to the latter. This study shows, on the one hand, the importance of bone remains as an indisputable resource in cases of forensic interest, and on the other hand the issues related to the genetic analysis of these samples because of the frequent presence of chemical-physical factors responsible for DNA degradation and/or inhibition.","PeriodicalId":109386,"journal":{"name":"Prevention and Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130048235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.11138/per/2015.4.1.029
R. Palumbo, A. Giannola
{"title":"Female age at first pregnancy and work task: finding correlation and evolution over the past two decades in a Sicilian province","authors":"R. Palumbo, A. Giannola","doi":"10.11138/per/2015.4.1.029","DOIUrl":"https://doi.org/10.11138/per/2015.4.1.029","url":null,"abstract":"","PeriodicalId":109386,"journal":{"name":"Prevention and Research","volume":"42 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126701397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.11138/PER/2016.5.4.134
M. C. Stefano
Introduction: scabies is a contagious parasitic disease which can cause hospital outbreaks, with possible involvement of sanitary staff, and considerable economic and managerial implications. The Policlinico San Matteo of Pavia adopts (since 2005) a protocol for the management of index cases, based on early patient isolation, identification of close contacts, and their prophylactic treatment. We report here descriptive data on reported cases of scabies and on the effectiveness of the
{"title":"Occupational risk of scabies among healthcare workers: problem focus and personal experience","authors":"M. C. Stefano","doi":"10.11138/PER/2016.5.4.134","DOIUrl":"https://doi.org/10.11138/PER/2016.5.4.134","url":null,"abstract":"Introduction: scabies is a contagious parasitic disease which can cause hospital outbreaks, with possible involvement of sanitary staff, and considerable economic and managerial implications. The Policlinico San Matteo of Pavia adopts (since 2005) a protocol for the management of index cases, based on early patient isolation, identification of close contacts, and their prophylactic treatment. We report here descriptive data on reported cases of scabies and on the effectiveness of the","PeriodicalId":109386,"journal":{"name":"Prevention and Research","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115637625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.11138/PER/2015.4.2.050
D. Arnaldi, F. Burla, M. E. Cinti, Antonella Carli
Introduction: the prevention and the early diagnosis in the treatment of breast cancer represents the main type of intervention able to change the course of the disease. The aim of the study is to highlight the peculiarities of the experience of cancer diagnosed inpatients. Materials and methods: through the content analysis the authors have examined, by performing chisquare test, 25 free content verbal reports of patients suffering from gynaecological cancer and 25 reports of patients with non-tumour disease, all in-patients in the same specialised department. Results: in the oncological patients group the results have showed the greatest frequency on emotional disorder and specific behaviour read as an expression of extended defensiveness and frequent references to the family members, in particular to the spouse and children (p<0.05). The two studied groups have in common the feelings of insecurity and the desire to obtain information about the disease. Shortly, the behaviours found in oncological patients can be traced back to the initial reaction of rejection and isolation, accompanied by an indirect request for contact with the family members. The content analysis has not disclosed the differences in the two groups about the perception of the treatment and health facilities ought to welcome the ill person. Discussion: the evaluation of the verbal reports can be the starting point to highlight and operate in any emotional disorder and maladjusted reactions which can further reduce the subjective wellbeing of the patient, compromising the adherence to the therapy and further debilitating, reducing the physical reaction against the neoplasia.
{"title":"Evaluation and prevention of maladaptive reactions in patients with gynaecological cancer: an experimental study of the expression of emotional experience.","authors":"D. Arnaldi, F. Burla, M. E. Cinti, Antonella Carli","doi":"10.11138/PER/2015.4.2.050","DOIUrl":"https://doi.org/10.11138/PER/2015.4.2.050","url":null,"abstract":"Introduction: the prevention and the early diagnosis in the treatment of breast cancer represents the main type of intervention able to change the course of the disease. The aim of the study is to highlight the peculiarities of the experience of cancer diagnosed inpatients. Materials and methods: through the content analysis the authors have examined, by performing chisquare test, 25 free content verbal reports of patients suffering from gynaecological cancer and 25 reports of patients with non-tumour disease, all in-patients in the same specialised department. Results: in the oncological patients group the results have showed the greatest frequency on emotional disorder and specific behaviour read as an expression of extended defensiveness and frequent references to the family members, in particular to the spouse and children (p<0.05). The two studied groups have in common the feelings of insecurity and the desire to obtain information about the disease. Shortly, the behaviours found in oncological patients can be traced back to the initial reaction of rejection and isolation, accompanied by an indirect request for contact with the family members. The content analysis has not disclosed the differences in the two groups about the perception of the treatment and health facilities ought to welcome the ill person. Discussion: the evaluation of the verbal reports can be the starting point to highlight and operate in any emotional disorder and maladjusted reactions which can further reduce the subjective wellbeing of the patient, compromising the adherence to the therapy and further debilitating, reducing the physical reaction against the neoplasia.","PeriodicalId":109386,"journal":{"name":"Prevention and Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114525739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.11138/PER/2014.3.2.054
Mariano Innocenzi
{"title":"Professional Cardiovascular Diseases: analysis of INAIL data from 2008 to 2012 and possible preventive aspects","authors":"Mariano Innocenzi","doi":"10.11138/PER/2014.3.2.054","DOIUrl":"https://doi.org/10.11138/PER/2014.3.2.054","url":null,"abstract":"","PeriodicalId":109386,"journal":{"name":"Prevention and Research","volume":"264 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130785014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.11138/PR/2012.1.2.062
Paola Burla
Background: The present background of the Italian National Health System requires the health professionals not only specific technical and operational skills, but also relational skills. Fast-changing work and life patterns may bring about situations which can be difficult to adapt to, even to the point of creating confusion and bewilderment.
{"title":"Professional profiles in the healthcare field and factors associated with the development of burnout","authors":"Paola Burla","doi":"10.11138/PR/2012.1.2.062","DOIUrl":"https://doi.org/10.11138/PR/2012.1.2.062","url":null,"abstract":"Background: The present background of the Italian National Health System requires the health professionals not only specific technical and operational skills, but also relational skills. Fast-changing work and life patterns may bring about situations which can be difficult to adapt to, even to the point of creating confusion and bewilderment.","PeriodicalId":109386,"journal":{"name":"Prevention and Research","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130969274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.11138/PER/2015.5.1.019
F. Serri
Introduction: the Authors have attempted to show the real effect in the Abruzzo region of mobbing incidents and work-related stress currently assessed in the insurance department handled by INAIL For this propose, the evaluations completed by INAIL between 2003-2013 on the compensation claims for certain effects on the health of the employees stemming from conduct attributable to workplace mobbing have been examined. Materials and Methods: all the results of cases submitted to the Medical Superintendent of the Abruzzo region from January 2003 to November 2013 were taken into consideration. The cases were subjected to the following diagnostic procedure: complete medical history, inspections of the workplaces, psychiatric visits, psychodiagnostic
{"title":"Mental disorders due to work-related mobbing in Abruzzo: analysis of the phenomenon between 2003-2013","authors":"F. Serri","doi":"10.11138/PER/2015.5.1.019","DOIUrl":"https://doi.org/10.11138/PER/2015.5.1.019","url":null,"abstract":"Introduction: the Authors have attempted to show the real effect in the Abruzzo region of mobbing incidents and work-related stress currently assessed in the insurance department handled by INAIL For this propose, the evaluations completed by INAIL between 2003-2013 on the compensation claims for certain effects on the health of the employees stemming from conduct attributable to workplace mobbing have been examined. Materials and Methods: all the results of cases submitted to the Medical Superintendent of the Abruzzo region from January 2003 to November 2013 were taken into consideration. The cases were subjected to the following diagnostic procedure: complete medical history, inspections of the workplaces, psychiatric visits, psychodiagnostic","PeriodicalId":109386,"journal":{"name":"Prevention and Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125958805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.11138/per/2017.6.4.070
F. Tomei
Introduction: The purpose of our study is to assess whether individual exposure to low-dose benzene in urban air may affect the plasma concentrations of cortisol in a population of outdoor workers in a large Italian city. Materials and methods: From a population of 1594 workers, 100 outdoor workers were selected. For each worker, a blood sampling was performed to measure benzene and cortisol. KolmogorovSmirnov test was used to verify the normality of distribution of the different variables. On the total sample, student T tests were performed for 2 mode variables (sex, smoke and job) and ANOVA test for variables with more than 2 modes (age and seniority). Pearson’s correlation index between 70 Prevention & Research 2017; 6(4):70-75 the variables in the total sample and after division on the basis of sex, smoking habit and manners was evaluated. Were considered significant results with p values below 0.05. Results: Our study did not show statistically significant correlations between blood benzene levels and cortisol in none of the groups studied. Discussion: Further studies are needed to confirm the existence of possible significant association between occupational exposure to benzene and cortisol levels alteration.
{"title":"Benzene and cortisol: relationship in workers exposed to outdoor pollution","authors":"F. Tomei","doi":"10.11138/per/2017.6.4.070","DOIUrl":"https://doi.org/10.11138/per/2017.6.4.070","url":null,"abstract":"Introduction: The purpose of our study is to assess whether individual exposure to low-dose benzene in urban air may affect the plasma concentrations of cortisol in a population of outdoor workers in a large Italian city. Materials and methods: From a population of 1594 workers, 100 outdoor workers were selected. For each worker, a blood sampling was performed to measure benzene and cortisol. KolmogorovSmirnov test was used to verify the normality of distribution of the different variables. On the total sample, student T tests were performed for 2 mode variables (sex, smoke and job) and ANOVA test for variables with more than 2 modes (age and seniority). Pearson’s correlation index between 70 Prevention & Research 2017; 6(4):70-75 the variables in the total sample and after division on the basis of sex, smoking habit and manners was evaluated. Were considered significant results with p values below 0.05. Results: Our study did not show statistically significant correlations between blood benzene levels and cortisol in none of the groups studied. Discussion: Further studies are needed to confirm the existence of possible significant association between occupational exposure to benzene and cortisol levels alteration.","PeriodicalId":109386,"journal":{"name":"Prevention and Research","volume":"336 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124721834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.11138/PR/2012.1.1.025
Alberto Battaglia
Introduzione: Lo studio valuta l’escrezione urinaria di 1-idrossipirene (1-OHP) in 108 lavoratori dell’asfalto che svolgevano la loro attività attenendosi scrupolosamente a criteri di carattere preventivo e protettivo coerenti con le specifiche indicazioni della Regione Lombardia. Obiettivi: Valutare la sensibilità del dosaggio dell’idrossipirene urinario come descrittore dell’esposizione a idrocarburi policiclici aromatici e valutare il contributo del fumo sull’escrezione urinaria dell’1-OHP. Metodi: Sono stati confrontati valori rilevati dopo 2 giorni di asfaltatura con valori dopo 2 giorni di inattività. Sono stati inoltre eseguiti confronti tra fumatori e non fumatori, e tra realizzazioni di pavimentazioni stradali all’aperto e asfaltatura in luoghi confinati. Risultati: Sono state riscontrate differenze non statisticamente significative nel dosaggio dell’1-OHP dopo asfaltatura rispetto all’1-OHP dopo inattività, eseguito nei medesimi soggetti. Tali differenze assumono invece significatività nel gruppo che ha svolto attività in ambiente confinato. Anche il confronto tra fumatori e non fumatori ha rilevato differenze non statisticamente significative. Conclusioni: L’1-OHP urinario è un indicatore che correla meglio con l’esposizione a fumi di bitume quando questa è particolarmente elevata, come avviene durante le operazioni di asfaltatura in luoghi confinati, mentre in caso di esposizioni molto basse, gli incrementi nella escrezione urinaria dell’indicatore, pur presenti, possono non assumere significatività statistica. Il fumo di sigaretta, noto per la sua interferenza con l’indicatore di esposizione esaminato, potrebbe averne limitato la specificità, ma non ha prodotto alterazioni significative nei test eseguiti in assenza di esposizione. Biological monitoring of asphalt workers by urinary 1-hydroxypyrene: comparison between outdoor and indoor paving www.preventionandresearch.com Jan-Mar 2012|P&R Scientific |Volume 2|N°1 82 Introduction Paving using bituminous mixtures involves a work-related exposure which depends on amount of time spent working and on the specific activity done. Variability of exposure is more relevant in terms of quantity than(for)quality of chemical hazards. Substances involved, mostly represented by polycyclic aromatic hydrocarbons (PAH), can be a hazard through different penetration ways (1, 2, 3, 4). Bitumen which is used as glue mixed with aggregate particles to create asphalt concrete, is a non volatile residue of petroleum refining process. Due to low levels of aromatic substances contained, bitumen is not classified by EU as carcinogen, as opposed to tar, a substance with similar uses but produced by coal refinery. Bitumen is useful in paving because it is solid at room temperature but fluid or liquid at higher temperatures, therefore it is used between 150°/180° C. Operating temperatures are much lower than boiling temperatures of each PAH. Melting and boiling temperatures of the most common PAH present in the bi
简介:这项研究评估了108名柏油路工人的尿排泄情况，他们的工作严格遵循与伦巴第地区的具体指示一致的预防和保护标准。目的:评估作为多环芳香烃暴露的描述符的尿羟基芘分析的敏感性，并评估烟对1- ohp尿排泄的贡献。方法:将两天沥青后的测量值与两天不活动后的测量值进行比较。此外，还比较了吸烟者和非吸烟者，以及在封闭地区铺设露天道路和铺沥青的情况。结果:在同一受试者中，沥青后1- ohp与不活跃后1- ohp的测定存在统计学上无显著差异。相反，这些差异对于在封闭环境中进行活动的组来说是显著的。吸烟者和非吸烟者之间的比较也显示出统计上没有显著差异。结论:尿L’1-OHP稳是一项指标,当这是更好地与暴露在烟雾、混凝土作业期间特别高,就像在一个有限的情况,而在地方展览指标很低,尿中排泄增加,同时,统计意义上不可能存在。以干扰测试的暴露指示器而闻名的吸烟可能会限制其特异性，但在没有暴露的情况下进行的测试并没有产生显著变化。生物监测of asphalt工人由urinary 1-hydroxypyrene:户外和室内之间的比较2012年paving www . preventionandresearch。com Jan-Mar | P&R科学| N°1第2卷| 82有引言paving bituminous mixtures involves a work-related暴露该depends on数额of time and spent working on the sco done。暴露的多样性比化学危害的质量更重要。由芳香多环芳烃hydrocarbons (PAH)所代表的物质，可通过不同的渗透方式(1、2、3、4)受到危害。两种低水平的芳香物质，沥青不是由欧盟作为致癌物分类的，而是由煤炭精炼厂生产的。沥青是有用的，因为它在房间里很坚固，但在更高的温度下是流动的或流动的。下面列出的沥青中最常见的PAH的熔融和煮沸温度。Molecule棒的(°C) Boiling(°C) Acenaphthene 95 279 Acenaphthylene 9180 275 Anthracene 217 3.4苯并(a) Anthracene 162 436,7苯并(a) pyrene 177 495癸二苯并(b) fluoranthene 168 481 (g, h, i) perylene 278 500苯并(k) fluoranthene 215 480 Chrysene 254 448苯并(a, h) Anthracene 266 524 Phenanthrene 96 340 fluoranthene 109 384芴116 295 (1,2,3-c,第164 (d) pyrene 497 Naphthalene 79 218 pyrene 145 404生物监测of asphalt工人由urinary 1-hydroxypyrene:户外和室内之间的比较2012年paving www . preventionandresearch。com Jan-Mar | P&R科学|第2卷| 1°83桌面As shown in the naphthalene,不要carcinogenic PAH,目前the lowest boiling是at最低温度高等than that丁汉is utilized 40°C。这就是为什么在通常的散步过程中，从液体(或某些固体)到气体状态的大规模变化是不可能的。很明显，这些口味的一小部分会发生变化，但预期的价值是如此之低，无法与其他来源的分子区分开来，比如交通和家庭供暖。2006年6月，伦巴第地区发布了一份名为《改善沥青制品工人健康与安全指南》(Vademecum for improving worers ' Health and Safety in沥青制品)的报告，并于2011年更新。在处理过程中，沥青温度的增加导致了空气传播的增加。The relevance of及其沉积相关在air and The presence of workers are The basis of The workers健康风险(在5、6、7)。在基础条件、博览会doc not appear to be或没有站立are剧情特别situations when The PAHs can amass and及其对糜烂in air becomes高等,as it is The房屋室内paving。 呼吸危害不是唯一的危害，因为在工作活动中，皮肤接触沥青可能发生在肮脏的工具中，也可能发生在被污染的衣服或个人防护设备中(8,9)。环境调查无法确定所有这些类型的暴露，因此需要一种与暴露于沥青烟雾更好相关的生物标志物(10)。urinary1 -羟基芘是芘的代谢物，芘是一种非致癌性多环芳烃，其存在与总多环芳烃不断相关(11,12,13)。因此，ACGIH认为，在每周轮班结束时(在工作周结束时)测量的尿液1-OHP是暴露于多环芳烃的生物学指标(14)。ACGIH将该生物标志物归类为NQ，非定量的，可能是由于暴露与代谢物排泄之间缺乏相关性(15)。目的评价尿中羟基芘作为多环芳烃暴露指标在标准条件下和室内铺装等高危环境下的敏感性。此外，文献中还报道了一些干扰1-OHP作为生物标志物的因素;其中最重要的是烟雾，因此它对尿排泄1-OHP的贡献已经被评估和评估。方法对108名从事不同工作的沥青工人进行抽样调查，这些工人均暴露于沥青烟雾中，并与沥青有皮肤接触。工作任务是:地面操作员，路面摊铺机司机，压路机操作员和维修工。考虑了室外和室内铺装。工人们严格遵守"伦巴第大区"在"改善沥青工程工人健康和安全条例"中规定的预防和保护政策进行日常活动。下面列出了该文档的主要特性。避免接触肮脏的设备和沥青乳液、润滑油、柴油和脂肪，特别是在清洁和维护车辆时。保持皮肤清洁干燥。勤洗手和洗脸。如厕后要洗手。在繁重的维护工作结束后，洗个澡。尿1-羟基芘对沥青工人的生物监测:室外和室内铺装的比较www.preventionandresearch.com 2012年1月- 3月P&R科学|卷2|N°84•不要穿脏或被污染的工作服:定期清洗。定期更换西装和工作服。避免衣服与工作服接触。在沥青生产和铺路过程中，禁止吃、喝或吸烟
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