Background: Traditional herbs have been used in the human healthcare system as medicines, foods, or spices from ancient times. Dolichos lablab is an Indian medicinal herb with a good source of nutrition, and has insulin-like proteins, thus can be employed in the cure of diabetes. Objective: This study aims to evaluate the lipids and blood glucose lowering effect of Dolichos lablab hydroalcoholic extract by using STZ-induced type 1 diabetes mellitus in-vivo model. Methods: Animals were divided into five groups including vehicle control, diabetic control, extract treated (200 & 400 mg/kg), and standard group. All the treatment was continued for 14 days after the confirmation of diabetes. Food consumption, water intake, serum glucose, insulin, kidney function test, liver, and serum lipid profile were assessed to evaluate the antidiabetic potential of the plant. Results: Phytochemical analysis showed the presence of carbohydrates, alkaloids, flavonoids, protein, amino acids, and terpenoids. Extract treatment significantly diminished HbA1c, and blood glucose levels. In addition, an ameliorative effect on serum cholesterol, triglycerides, and lipoprotein was observed at 400 mg/kg/day dose. Moreover, blood urea nitrogen and hepatic SGPT were also reduced significantly with extract treatment. Conclusion: Therefore, the present study depicted that Dolichos lablab is a useful herb in diabetes management and possesses hypolipidemic potential.
{"title":"Antihyperglycemic and Hypolipidemic Effect of Hydroalcoholic Extract of Dolichos lablab Linn in STZ induced Type 1 Diabetes Mellitus in Mice","authors":"Hari Kishan, Manjusha Choudhary, Sachin Sharma, Prabhjeet Kaur Bamrah, Nitesh Choudhary","doi":"10.2174/2215083810666230908155424","DOIUrl":"https://doi.org/10.2174/2215083810666230908155424","url":null,"abstract":"Background: Traditional herbs have been used in the human healthcare system as medicines, foods, or spices from ancient times. Dolichos lablab is an Indian medicinal herb with a good source of nutrition, and has insulin-like proteins, thus can be employed in the cure of diabetes. Objective: This study aims to evaluate the lipids and blood glucose lowering effect of Dolichos lablab hydroalcoholic extract by using STZ-induced type 1 diabetes mellitus in-vivo model. Methods: Animals were divided into five groups including vehicle control, diabetic control, extract treated (200 & 400 mg/kg), and standard group. All the treatment was continued for 14 days after the confirmation of diabetes. Food consumption, water intake, serum glucose, insulin, kidney function test, liver, and serum lipid profile were assessed to evaluate the antidiabetic potential of the plant. Results: Phytochemical analysis showed the presence of carbohydrates, alkaloids, flavonoids, protein, amino acids, and terpenoids. Extract treatment significantly diminished HbA1c, and blood glucose levels. In addition, an ameliorative effect on serum cholesterol, triglycerides, and lipoprotein was observed at 400 mg/kg/day dose. Moreover, blood urea nitrogen and hepatic SGPT were also reduced significantly with extract treatment. Conclusion: Therefore, the present study depicted that Dolichos lablab is a useful herb in diabetes management and possesses hypolipidemic potential.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136361818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-07DOI: 10.2174/2215083810666230907093431
Rashmi Rani, Sumitra Nain, Survesh Kumar Paliwal
Background: Medicago sativa Linn. in Hindi, is called lasunghas, and in English, it is called alfalfa. It is a well-known crop of the Fabaceae family. We can eat its sprouts as a salad vegetable. This plant has a wide range of uses as a feed crop and is tolerant to climate change. Objective: In this review, the authors discussed the active chemical constituents and pharmacological uses of Medicago sativa Linn. in various diseases. Methods: This review article gathered all the information after going through the research papers from different databases like Taylor & Francis, ResearchGate, Elsevier, PubMed, Wiley Online Library, and PMC. Results: Alfalfa has been shown to be an important origin of phytochemicals like amino acids, coumarins, alkaloids, carotenes, flavonoids, organic acids, digestive enzymes, phytosterols, saponins, phytoestrogens, phenolic compounds, polyamines, and a few other volatile organic compounds like ketones, terpenes, alcohols and furanoids. This plant is useful in CNS, anxiety, oxidative stress, hepatotoxicity, inflammation, cancer, atherosclerosis, diabetes, burn wounds, vitiligo, reproductive system, myocardial infraction, bacteria, xanthine oxidase and metabolic syndrome. Conclusion: This review may be helpful in knowing of Medicago sativa Linn. with greater therapeutic potential for treatment of various diseases.
{"title":"A Review on Pharmacological Potential of Medicago sativa Linn.","authors":"Rashmi Rani, Sumitra Nain, Survesh Kumar Paliwal","doi":"10.2174/2215083810666230907093431","DOIUrl":"https://doi.org/10.2174/2215083810666230907093431","url":null,"abstract":"Background: Medicago sativa Linn. in Hindi, is called lasunghas, and in English, it is called alfalfa. It is a well-known crop of the Fabaceae family. We can eat its sprouts as a salad vegetable. This plant has a wide range of uses as a feed crop and is tolerant to climate change. Objective: In this review, the authors discussed the active chemical constituents and pharmacological uses of Medicago sativa Linn. in various diseases. Methods: This review article gathered all the information after going through the research papers from different databases like Taylor & Francis, ResearchGate, Elsevier, PubMed, Wiley Online Library, and PMC. Results: Alfalfa has been shown to be an important origin of phytochemicals like amino acids, coumarins, alkaloids, carotenes, flavonoids, organic acids, digestive enzymes, phytosterols, saponins, phytoestrogens, phenolic compounds, polyamines, and a few other volatile organic compounds like ketones, terpenes, alcohols and furanoids. This plant is useful in CNS, anxiety, oxidative stress, hepatotoxicity, inflammation, cancer, atherosclerosis, diabetes, burn wounds, vitiligo, reproductive system, myocardial infraction, bacteria, xanthine oxidase and metabolic syndrome. Conclusion: This review may be helpful in knowing of Medicago sativa Linn. with greater therapeutic potential for treatment of various diseases.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135096565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-05DOI: 10.2174/2215083810666230905152757
H.R. Topiya, D.J. Pandya
ABSTRACT: The ancient science of life known as Ayurveda offers countless potential to uncover many unexplored manuscripts that lead to effective medications. Understanding traditional medicinal plants can open up a wealth of significant bioactive phytoconstituents with numerous significant pharmacological functions. This treasure must be located based on the understanding of old Ayurveda and other traditional references. Sapindaceae family member Cardiospermum halicacabum Linn. is a rich source of phytochemicals, including tannins, saponins, phenols, flavonoids, terpenoids, alkaloids, and sterols. Many of these phytochemicals exhibit antioxidant, anxiolytic, anti-inflammatory, anti-ulcer, anti-cancer, anti-microbial, antifungal, anti-bacterial, anti-diabetic, immunomodulatory, antiviral, cardioprotective, mainly neuroprotective properties according to Ayurveda. The plants' aerial parts are rich in phenolic acids, glycosidic compounds, tannins, and sterols. Researchers and academicians are examining the pharmacognosy, phytochemistry, and other pharmacological effects of the traditional medicinal plant known as Karnasphota (Cardiospermum halicacabum Linn.), which is cited in Ayurveda as one of the neuroprotective agents. Karnasphota (Cardiospermum halicacabum Linn.) is shown to have promising therapeutic potential by the scientific evidence offered by researchers and academics, and it can be further assessed as a novel candidate for drug discovery. The current review aims to examine the potential of the underexplored herb from Ayurveda "Karnasphota" for developing and designing future medications by reviewing the existence of medicinally significant secondary metabolites, potential pharmacological importance, and its role in neuroprotection in neurodegenerative diseases.
{"title":"Karnasphota: A neuroprotective herb from the treasure of Ayurveda","authors":"H.R. Topiya, D.J. Pandya","doi":"10.2174/2215083810666230905152757","DOIUrl":"https://doi.org/10.2174/2215083810666230905152757","url":null,"abstract":"ABSTRACT: The ancient science of life known as Ayurveda offers countless potential to uncover many unexplored manuscripts that lead to effective medications. Understanding traditional medicinal plants can open up a wealth of significant bioactive phytoconstituents with numerous significant pharmacological functions. This treasure must be located based on the understanding of old Ayurveda and other traditional references. Sapindaceae family member Cardiospermum halicacabum Linn. is a rich source of phytochemicals, including tannins, saponins, phenols, flavonoids, terpenoids, alkaloids, and sterols. Many of these phytochemicals exhibit antioxidant, anxiolytic, anti-inflammatory, anti-ulcer, anti-cancer, anti-microbial, antifungal, anti-bacterial, anti-diabetic, immunomodulatory, antiviral, cardioprotective, mainly neuroprotective properties according to Ayurveda. The plants' aerial parts are rich in phenolic acids, glycosidic compounds, tannins, and sterols. Researchers and academicians are examining the pharmacognosy, phytochemistry, and other pharmacological effects of the traditional medicinal plant known as Karnasphota (Cardiospermum halicacabum Linn.), which is cited in Ayurveda as one of the neuroprotective agents. Karnasphota (Cardiospermum halicacabum Linn.) is shown to have promising therapeutic potential by the scientific evidence offered by researchers and academics, and it can be further assessed as a novel candidate for drug discovery. The current review aims to examine the potential of the underexplored herb from Ayurveda \"Karnasphota\" for developing and designing future medications by reviewing the existence of medicinally significant secondary metabolites, potential pharmacological importance, and its role in neuroprotection in neurodegenerative diseases.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135363218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.2174/2215083810666230901115602
D. Patel
Nature is the best source of all raw materials that we need for growth, development, and better health. Flavonoids are an important class of phytochemicals found to be present in plants and their derived byproducts. Lonicera japonica and its active phytochemicals possess antiviral, anti-endotoxin, anti-pyretic, and blood fat-reducing properties in medicine. Moreover, Galuteolin is a natural flavonoid that has anti-oxidant, anti-tumor, anti-infective, and anti-inflammatory potential. In the present review article, we have collected all scientific information on galuteolin from different scientific databases and analyzed it to know the biological importance and therapeutic benefit of galuteolin in medicine against human disorders. Scientific data on galuteolin were collected from numerous literature databases, such as Google, Google Scholar, PubMed, Scopus and Science Direct. Detailed pharmacological data on galuteolin were collected from these scientific sources and analyzed in the present work to know the health-beneficial aspects of galuteolin in medicine. In addition, scientific data on analytical techniques of galuteolin were also collected and analyzed in the present work to know their importance in the separation, isolation, and identification of galuteolin in different plant materials. The present work signified the biological importance of galuteolin in medicine and other allied health sectors. Pharmacological data analysis revealed the health-beneficial aspects of galuteolin on rheumatoid arthritis, cerebral ischemia, carcinoma, COVID-19, Atherosclerosis, and melanin biosynthesis. Further, intestinal absorption and pharmacokinetic parameters of galuteolin were also discussed in the present work. Analytical data signified the importance of newer and modern analytical techniques in medicine for the qualitative and quantitative analysis of galuteolin in different biological samples. Scientific data analysis of galuteolin revealed its biological importance and therapeutic benefit in medicine.
{"title":"Ethnomedicinal uses, Pharmacological activity, and Analytical aspects of Galuteolin: A Natural Flavonoid of Medicinal Importance","authors":"D. Patel","doi":"10.2174/2215083810666230901115602","DOIUrl":"https://doi.org/10.2174/2215083810666230901115602","url":null,"abstract":"\u0000\u0000Nature is the best source of all raw materials that we need for growth, development, and better health. Flavonoids are an important class of phytochemicals found to be present in plants and their derived byproducts. Lonicera japonica and its active phytochemicals possess antiviral, anti-endotoxin, anti-pyretic, and blood fat-reducing properties in medicine. Moreover, Galuteolin is a natural flavonoid that has anti-oxidant, anti-tumor, anti-infective, and anti-inflammatory potential.\u0000\u0000\u0000\u0000In the present review article, we have collected all scientific information on galuteolin from different scientific databases and analyzed it to know the biological importance and therapeutic benefit of galuteolin in medicine against human disorders. Scientific data on galuteolin were collected from numerous literature databases, such as Google, Google Scholar, PubMed, Scopus and Science Direct. Detailed pharmacological data on galuteolin were collected from these scientific sources and analyzed in the present work to know the health-beneficial aspects of galuteolin in medicine. In addition, scientific data on analytical techniques of galuteolin were also collected and analyzed in the present work to know their importance in the separation, isolation, and identification of galuteolin in different plant materials.\u0000\u0000\u0000\u0000The present work signified the biological importance of galuteolin in medicine and other allied health sectors. Pharmacological data analysis revealed the health-beneficial aspects of galuteolin on rheumatoid arthritis, cerebral ischemia, carcinoma, COVID-19, Atherosclerosis, and melanin biosynthesis. Further, intestinal absorption and pharmacokinetic parameters of galuteolin were also discussed in the present work. Analytical data signified the importance of newer and modern analytical techniques in medicine for the qualitative and quantitative analysis of galuteolin in different biological samples.\u0000\u0000\u0000\u0000Scientific data analysis of galuteolin revealed its biological importance and therapeutic benefit in medicine.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48437455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.2174/2215083810666230831154738
Abdnim Rhizlan, Elbouzidi Amine, Hayat Ouassou, Amal Elrherabi, Ali Berraaouan, Abdelkhaleq Legssyer, A. Ziyyat, Hassane Mekhfi, M. Bnouham
Moroccan medicinal plants with historical usage to treat diabetes have been analyzed to explore their potential anti-glycation and antioxidant activities through in vitro experiments. These investigations have been complemented by molecular docking. The present study has examined the in vitro antioxidant and antiglycation properties of six aqueous extracts from six medicinal plants (Ammodaucus leucotrichus, Thymelaea hirsuta, Arbutus unedo, Urtica dioica, Ptychotis verticillata, and Caralluma europaea), and two seeds oils from Argania spinosa and Opuntia dillenii. The antioxidant activity was determined by using the DPPH radical scavenging activity test and β-carotene/linoleic acid bleaching assay. In addition, the antiglycation activity was detected by using the hemoglobin protein model. All studied plant extracts have shown potent antioxidant and antiglycation activity. Furthermore, to confirm the in silico antiglycation activity of the selected medicinal plants, molecular docking techniques were used assuming that binding energy decreases as compound affinity increases; the best molecules responsible for the remarkable antiglycation activity have also been highlighted. Antidiabetic herbal medicines are responsible for the inhibition of oxidative activity and glycation. The molecular docking analysis showed catechin, kaempferol-O-acetylhexoside, luteolin, luteolin-7-O-glucoside, quercetin, and zeaxanthin, to have a high affinity to AGEs receptor and a potent inhibitory activity.
通过体外实验，分析了摩洛哥药用植物治疗糖尿病的历史，探讨了其潜在的抗糖基化和抗氧化活性。这些研究得到了分子对接的补充。本文研究了六种药用植物(白毛杉、百里菊、杨梅、荨麻、斑蝶和木犀草)的六种水提取物和两种植物种子油的体外抗氧化和抗糖基化特性。采用DPPH自由基清除活性试验和β-胡萝卜素/亚油酸漂白试验测定其抗氧化活性。此外，采用血红蛋白模型检测其抗糖化活性。所有研究的植物提取物都显示出有效的抗氧化和抗糖基化活性。此外，为了确认所选药用植物的硅抗糖基化活性，采用分子对接技术假设结合能随着化合物亲和力的增加而降低;具有显著的抗糖化活性的最佳分子也被强调。抗糖尿病的草药负责抑制氧化活性和糖基化。分子对接分析表明，儿茶素、山奈酚- o -乙酰己糖苷、木犀草素、木犀草素-7- o -葡萄糖苷、槲皮素和玉米黄质对AGEs受体具有较高的亲和力和较强的抑制活性。
{"title":"In vitro Study on Antioxidant and Antiglycation Activities, and Molecular Docking of Moroccan Medicinal Plants for Diabetes","authors":"Abdnim Rhizlan, Elbouzidi Amine, Hayat Ouassou, Amal Elrherabi, Ali Berraaouan, Abdelkhaleq Legssyer, A. Ziyyat, Hassane Mekhfi, M. Bnouham","doi":"10.2174/2215083810666230831154738","DOIUrl":"https://doi.org/10.2174/2215083810666230831154738","url":null,"abstract":"\u0000\u0000Moroccan medicinal plants with historical usage to treat diabetes have been analyzed to explore their potential anti-glycation and antioxidant activities through in vitro experiments. These investigations have been complemented by molecular docking.\u0000\u0000\u0000\u0000The present study has examined the in vitro antioxidant and antiglycation properties of six aqueous extracts from six medicinal plants (Ammodaucus leucotrichus, Thymelaea hirsuta, Arbutus unedo, Urtica dioica, Ptychotis verticillata, and Caralluma europaea), and two seeds oils from Argania spinosa and Opuntia dillenii. The antioxidant activity was determined by using the DPPH radical scavenging activity test and β-carotene/linoleic acid bleaching assay. In addition, the antiglycation activity was detected by using the hemoglobin protein model.\u0000\u0000\u0000\u0000All studied plant extracts have shown potent antioxidant and antiglycation activity. Furthermore, to confirm the in silico antiglycation activity of the selected medicinal plants, molecular docking techniques were used assuming that binding energy decreases as compound affinity increases; the best molecules responsible for the remarkable antiglycation activity have also been highlighted.\u0000\u0000\u0000\u0000Antidiabetic herbal medicines are responsible for the inhibition of oxidative activity and glycation. The molecular docking analysis showed catechin, kaempferol-O-acetylhexoside, luteolin, luteolin-7-O-glucoside, quercetin, and zeaxanthin, to have a high affinity to AGEs receptor and a potent inhibitory activity.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44938653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-30DOI: 10.2174/2215083810666230830125242
V. Vinu, J. Srikanth, Nagendra Prasad K, Lancy Dsouza
Yoga has its roots in India's Vedic era. Practising it enhances the overall health and well-being of students. Superbrain yoga (SBY) is a brief exercise based on the principle of ear acupuncture and repetitive 14 squats. It is practised by many students in India and across other parts of the world. This systematic review assesses SBY on students' cognitive abilities, academic performance, as well as mental health benefits and discusses if using SBY in academic settings is viable. The intervention studies of SBY or mixed with other exercises practiced by the student population published in journals and indexed in Web of Science, SCOPUS, and PubMed, are taken into consideration for this review based on PRISMA guidelines. The primary keywords include Superbrain Yoga, Thoppukaranam, and Super Brain Yoga. Studies published in English peer-reviewed journals between 2005 to 2021 were considered. Fifteen studies met the inclusion criteria. The review found that SBY practise was feasible in academic settings, with advantages to students' cognitive state (memory, attention, concentration), academic performance, and mental health Additionally, SBY and other yogasana were proven to be beneficial in raising cognitive activity and promoting positive behavioural improvements in students with special needs. More rigorous trials on SBY are needed to substantiate the effectiveness.
瑜伽起源于印度的吠陀时代。练习它可以提高学生的整体健康和福祉。超级大脑瑜伽(SBY)是一种基于耳针和重复深蹲原理的简短运动。印度和世界其他地区的许多学生都在练习。本系统综述评估了SBY对学生认知能力、学习成绩以及心理健康的益处，并讨论了在学术环境中使用SBY是否可行。根据PRISMA指南，本综述考虑了发表在期刊上并被Web of Science、SCOPUS和PubMed索引的学生群体进行的SBY干预研究或与其他练习混合进行的研究。主要关键词包括超级大脑瑜伽，Thoppukaranam和超级大脑瑜伽。研究人员考虑了2005年至2021年间发表在英文同行评议期刊上的研究。15项研究符合纳入标准。审查发现，在学术环境中，SBY练习是可行的，对学生的认知状态(记忆、注意力、注意力)、学习成绩和心理健康都有好处。此外，SBY和其他瑜伽体式被证明对有特殊需要的学生提高认知活动和促进积极的行为改善是有益的。需要对SBY进行更严格的试验来证实其有效性。
{"title":"Viability of Superbrain Yoga Practise in Academic Setting: A Systematic Review","authors":"V. Vinu, J. Srikanth, Nagendra Prasad K, Lancy Dsouza","doi":"10.2174/2215083810666230830125242","DOIUrl":"https://doi.org/10.2174/2215083810666230830125242","url":null,"abstract":"\u0000\u0000Yoga has its roots in India's Vedic era. Practising it enhances the overall health and well-being of students. Superbrain yoga (SBY) is a brief exercise based on the principle of ear acupuncture and repetitive 14 squats. It is practised by many students in India and across other parts of the world.\u0000\u0000\u0000\u0000This systematic review assesses SBY on students' cognitive abilities, academic performance, as well as mental health benefits and discusses if using SBY in academic settings is viable.\u0000\u0000\u0000\u0000The intervention studies of SBY or mixed with other exercises practiced by the student population published in journals and indexed in Web of Science, SCOPUS, and PubMed, are taken into consideration for this review based on PRISMA guidelines. The primary keywords include Superbrain Yoga, Thoppukaranam, and Super Brain Yoga. Studies published in English peer-reviewed journals between 2005 to 2021 were considered.\u0000\u0000\u0000\u0000Fifteen studies met the inclusion criteria. The review found that SBY practise was feasible in academic settings, with advantages to students' cognitive state (memory, attention, concentration), academic performance, and mental health Additionally, SBY and other yogasana were proven to be beneficial in raising cognitive activity and promoting positive behavioural improvements in students with special needs.\u0000\u0000\u0000\u0000More rigorous trials on SBY are needed to substantiate the effectiveness.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43389944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-30DOI: 10.2174/2215083810666230830125306
Farina Pramanik, M. Satari, A. Azhari
Uncaria gambir is an Indonesian medicinal herb with healing effects. This plant contains flavonoids, which can be used as antioxidants and anti-inflammatory agents to accelerate healing. In Indonesia, Uncaria gambir is widely accessible, simple to grow, and has a long history of use as an alternative medicine. Following this, studies are conducted in the medical industry using Uncaria gambir. This study aimed to comprehensively review the use of Uncaria gambir extract as an herbal plant for treating experimental animals. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and the risk of bias was evaluated by modifying the ARRIVE guidelines. A report was presented on review articles from 12 publications sourced from PubMed, ScienceDirect, Wiley Online Library, ProQuest, EBSCO Host, and other relevant studies. The Uncaria gambir isolates tested were catechin and ethyl acetate, used primarily for lesions, pain, edema, and diabetes in experimental Wistar rats. Uncaria gambir is an herbal plant that contains flavonoids, which can be used as anti-inflammatory, antioxidant, antibacterial, and hepatoprotective agents and can potentially be applied in the medical field as adjuvant therapy.
{"title":"Therapeutic potential of the herbal plant Uncaria gambir: A systematic review","authors":"Farina Pramanik, M. Satari, A. Azhari","doi":"10.2174/2215083810666230830125306","DOIUrl":"https://doi.org/10.2174/2215083810666230830125306","url":null,"abstract":"\u0000\u0000Uncaria gambir is an Indonesian medicinal herb with healing effects. This plant contains flavonoids, which can be used as antioxidants and anti-inflammatory agents to accelerate healing. In Indonesia, Uncaria gambir is widely accessible, simple to grow, and has a long history of use as an alternative medicine. Following this, studies are conducted in the medical industry using Uncaria gambir.\u0000\u0000\u0000\u0000This study aimed to comprehensively review the use of Uncaria gambir extract as an herbal plant for treating experimental animals.\u0000\u0000\u0000\u0000This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and the risk of bias was evaluated by modifying the ARRIVE guidelines.\u0000\u0000\u0000\u0000A report was presented on review articles from 12 publications sourced from PubMed, ScienceDirect, Wiley Online Library, ProQuest, EBSCO Host, and other relevant studies. The Uncaria gambir isolates tested were catechin and ethyl acetate, used primarily for lesions, pain, edema, and diabetes in experimental Wistar rats.\u0000\u0000\u0000\u0000Uncaria gambir is an herbal plant that contains flavonoids, which can be used as anti-inflammatory, antioxidant, antibacterial, and hepatoprotective agents and can potentially be applied in the medical field as adjuvant therapy.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44361760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.2174/2215083810666230828113447
S. M, Rukaiah Fatma Begum, S. Suresh, V. S. Devi, Muralidhar Moka
Vitamin E influences hormonal parameters in women, but the evidence concerning its effectiveness in polycystic ovarian syndrome (PCOS) are constrained. The objective of this systematic review is to perceive the mechanism behind the hormonal effects of vitamin E in PCOS and explore the effectiveness of vitamin E by analyzing the clinical studies. Electronic bibliographic databases, such as PubMed, Scopus, ProQuest, DOAJ, ScienceDirect, and Cochrane Library, were searched for clinical studies scrutinizing the effect of vitamin E supplementation on PCOS. The systematic review protocol is registered in PROSPERO (CRD42021272963) and was performed as per the PRISMA guidelines. Records analyzing the hormonal parameters were included. For individual study, the risk of bias was ascertained with NHLBI protocol for controlled randomized studies. There were 1438 records identified, of which seven records were retrieved which met the inclusion criteria. Bibliographic details, number of participants, the dose of vitamin E, duration of the treatment and trial, parameters analyzed, and outcome of each study were extracted comprehensively. In the review, the majority of the studies embraced high-quality studies, which included double-blinded controlled trials, open-label controlled studies, and cohort studies. Vitamin E implies having a progesterone-like impression with estrogenic and androgenic properties. Furthermore, the ability of vitamin E as an antioxidant is also advantageous in PCOS women. However, there is a lack of empirical evidence on its mechanism, and the inadequacy of large-scale concerns about different age groups against PCOS is requisite.
{"title":"Does Vitamin E Supplementation Alter Hormonal Levels in Polycystic Ovary Syndrome: A Systematic Review of Randomized Controlled Trials","authors":"S. M, Rukaiah Fatma Begum, S. Suresh, V. S. Devi, Muralidhar Moka","doi":"10.2174/2215083810666230828113447","DOIUrl":"https://doi.org/10.2174/2215083810666230828113447","url":null,"abstract":"Vitamin E influences hormonal parameters in women, but the evidence concerning its effectiveness in polycystic ovarian syndrome (PCOS) are constrained. The objective of this systematic review is to perceive the mechanism behind the hormonal effects of vitamin E in PCOS and explore the effectiveness of vitamin E by analyzing the clinical studies. Electronic bibliographic databases, such as PubMed, Scopus, ProQuest, DOAJ, ScienceDirect, and Cochrane Library, were searched for clinical studies scrutinizing the effect of vitamin E supplementation on PCOS. The systematic review protocol is registered in PROSPERO (CRD42021272963) and was performed as per the PRISMA guidelines. Records analyzing the hormonal parameters were included. For individual study, the risk of bias was ascertained with NHLBI protocol for controlled randomized studies. There were 1438 records identified, of which seven records were retrieved which met the inclusion criteria. Bibliographic details, number of participants, the dose of vitamin E, duration of the treatment and trial, parameters analyzed, and outcome of each study were extracted comprehensively. In the review, the majority of the studies embraced high-quality studies, which included double-blinded controlled trials, open-label controlled studies, and cohort studies. Vitamin E implies having a progesterone-like impression with estrogenic and androgenic properties. Furthermore, the ability of vitamin E as an antioxidant is also advantageous in PCOS women. However, there is a lack of empirical evidence on its mechanism, and the inadequacy of large-scale concerns about different age groups against PCOS is requisite.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"10 1-2","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41301872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-23DOI: 10.2174/2215083810666230823094940
Diptayan Adhikari, Jayati Biswas, Bitihotra De, Bani Kumar Pathak
Various neurodegenerative diseases have become a serious threat to human health all around the world. The progressive loss of functionality of active neurons causes neurodegenerative disease. Current research suggests that plant-derived foods, such as fruits and vegetables, are a good source of natural polyphenols, which can be effective in reducing the risk factors of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), etc. These polyphenols exhibit cognitive repair and can reduce the production of reactive oxygen species (ROS) to establish neuroprotection. Various animal models were developed to understand the neuromodulatory and therapeutic activities of polyphenols for the treatment of AD, PD, HD, etc. Moreover, polyphenols indirectly modulate the gut microbiome to generate neuroprotection. Although there is a disadvantage to the low oral bioavailability of these polyphenols, the conjugation can enhance the efficiency of these compounds with nanoparticles. The present review gives an outline of plant-generated polyphenols and highlights their effects in the treatment of various neurodegenerative diseases. As a result, the prevention of aging-related disorders through natural products certainly shows excellent therapeutic efficiency soon. For this study, various reviews as well as original research articles from PubMed describing the possible therapeutic effects of dietary polyphenols to cure neurodegenerative diseases are used.
{"title":"A Review on the Effective Implications of Plant-generated Polyphenols as Novel Therapeutic Agents against Neurodegenerative Diseases","authors":"Diptayan Adhikari, Jayati Biswas, Bitihotra De, Bani Kumar Pathak","doi":"10.2174/2215083810666230823094940","DOIUrl":"https://doi.org/10.2174/2215083810666230823094940","url":null,"abstract":"\u0000\u0000Various neurodegenerative diseases have become a serious threat to human health all around the world. The progressive loss of functionality of active neurons causes neurodegenerative disease. Current research suggests that plant-derived foods, such as fruits and vegetables, are a good source of natural polyphenols, which can be effective in reducing the risk factors of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), etc. These polyphenols exhibit cognitive repair and can reduce the production of reactive oxygen species (ROS) to establish neuroprotection. Various animal models were developed to understand the neuromodulatory and therapeutic activities of polyphenols for the treatment of AD, PD, HD, etc. Moreover, polyphenols indirectly modulate the gut microbiome to generate neuroprotection. Although there is a disadvantage to the low oral bioavailability of these polyphenols, the conjugation can enhance the efficiency of these compounds with nanoparticles. The present review gives an outline of plant-generated polyphenols and highlights their effects in the treatment of various neurodegenerative diseases. As a result, the prevention of aging-related disorders through natural products certainly shows excellent therapeutic efficiency soon. For this study, various reviews as well as original research articles from PubMed describing the possible therapeutic effects of dietary polyphenols to cure neurodegenerative diseases are used.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45622294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-22DOI: 10.2174/2215083810666230822100119
Marí Castro Santos, A. Mendez, A. Henriques
Species from the Cuphea genus (Lythraceae) have wide usage in traditional medicine for the treatment of various diseases. Cuphea comprises about 260 species distributed worldwide among five continents. This systematic review aimed to synthesize the information available about the traditional uses, phytochemistry, pharmacology, and toxicology of Cuphea spp. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria, with a search in the scientific databases, namely Scopus, Web of Science, PubMed, and ScienceDirect, using keywords, such as “Cuphea”, “sete-sangrias”, “Cuphea” and “polyphenols”, “Cuphea” and “flavonoid”, “Cuphea” and “pharmacology”, “Cuphea” and “traditional uses”, “Cuphea” and “toxicology”, and all references found were analyzed. Among 1438 publications identified in the initial screening, 86 studies were included based on eligibility criteria. The chemical composition of Cuphea spp. is mainly polyphenols related to therapeutic use, especially as an antioxidant, antimicrobial, antitumoral, anti-inflammation, and antihypertensive. In summary, this systematic review provides an overview of the active compounds responsible for the pharmacological actions of the genus, often linked to traditional use. However, its safety and potential toxicology need to be further studied, along with the bioactive mechanisms and discussion of the structure-activity relationship, besides future clinical studies for novel drug development.
赤藓属(赤藓科)在传统医学中有广泛的用途，用于治疗各种疾病。Cuphea约有260种，分布在世界五大洲。本系统综述以“Cuphea”、“sete-sangrias”、“Cuphea”和“polyphenols”、“Cuphea”和“flavonoid”为关键词，按照PRISMA (Preferred Reporting Items for systematic Reviews and meta - analysis)标准，检索Scopus、Web of Science、PubMed和ScienceDirect等科学数据库，综合有关Cuphea的传统用途、植物化学、药理学和毒理学等方面的现有信息。对“Cuphea”与“药理学”、“Cuphea”与“传统用法”、“Cuphea”与“毒理学”等文献资料进行分析。在最初筛选确定的1438份出版物中，根据资格标准纳入了86项研究。茶茶属植物的化学成分主要是多酚类，具有抗氧化、抗菌、抗肿瘤、抗炎症和降压等作用。综上所述，本系统综述提供了负责该属药理作用的活性化合物的概述，通常与传统用途有关。但其安全性和潜在毒理学研究、生物活性机制和构效关系的探讨，以及未来新药开发的临床研究仍需进一步深入。
{"title":"Cuphea Genus: A Systematic Review on the Traditional Uses, Phytochemistry, Pharmacology, and Toxicology","authors":"Marí Castro Santos, A. Mendez, A. Henriques","doi":"10.2174/2215083810666230822100119","DOIUrl":"https://doi.org/10.2174/2215083810666230822100119","url":null,"abstract":"\u0000\u0000Species from the Cuphea genus (Lythraceae) have wide usage in traditional medicine for the treatment of various diseases. Cuphea comprises about 260 species distributed worldwide among five continents.\u0000\u0000\u0000\u0000This systematic review aimed to synthesize the information available about the traditional uses, phytochemistry, pharmacology, and toxicology of Cuphea spp. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria, with a search in the scientific databases, namely Scopus, Web of Science, PubMed, and ScienceDirect, using keywords, such as “Cuphea”, “sete-sangrias”, “Cuphea” and “polyphenols”, “Cuphea” and “flavonoid”, “Cuphea” and “pharmacology”, “Cuphea” and “traditional uses”, “Cuphea” and “toxicology”, and all references found were analyzed. Among 1438 publications identified in the initial screening, 86 studies were included based on eligibility criteria. The chemical composition of Cuphea spp. is mainly polyphenols related to therapeutic use, especially as an antioxidant, antimicrobial, antitumoral, anti-inflammation, and antihypertensive.\u0000\u0000\u0000\u0000In summary, this systematic review provides an overview of the active compounds responsible for the pharmacological actions of the genus, often linked to traditional use.\u0000\u0000\u0000\u0000However, its safety and potential toxicology need to be further studied, along with the bioactive mechanisms and discussion of the structure-activity relationship, besides future clinical studies for novel drug development.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42043664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：