Pub Date : 2023-08-22DOI: 10.2174/2215083810666230822113623
Y. Siddique, Iqra Subhan
Hesperidin is a major flavonoid in sweet oranges and lemons. Aglycone form of hesperidin i.e., hesperetin, and their various derivatives possess significant potential as therapeutic agents for a wide range of diseases and disorders. No signs of toxicity have been observed with the normal intake of hesperidin or related compounds. Hesperidin has been reported to possess a wide range of pharmacological properties, which includes antioxidant, anti-viral, anticancer, antidiabetic, analgesic, organ protective, neuroprotective, antihypertensive, and cardioprotective effects. This needs to be effectively studied at the clinical level so as to firmly establish the usefulness of these compounds in the treatment or prevention of disease in humans. This paper reviews various aspects of hesperidin, including their chemistry, biosynthesis, and bioactivity.
{"title":"Pharmacological Attributes of Hesperidin","authors":"Y. Siddique, Iqra Subhan","doi":"10.2174/2215083810666230822113623","DOIUrl":"https://doi.org/10.2174/2215083810666230822113623","url":null,"abstract":"Hesperidin is a major flavonoid in sweet oranges and lemons. Aglycone form of hesperidin i.e., hesperetin, and their various derivatives possess significant potential as therapeutic agents for a wide range of diseases and disorders. No signs of toxicity have been observed with the normal intake of hesperidin or related compounds. Hesperidin has been reported to possess a wide range of pharmacological properties, which includes antioxidant, anti-viral, anticancer, antidiabetic, analgesic, organ protective, neuroprotective, antihypertensive, and cardioprotective effects. This needs to be effectively studied at the clinical level so as to firmly establish the usefulness of these compounds in the treatment or prevention of disease in humans. This paper reviews various aspects of hesperidin, including their chemistry, biosynthesis, and bioactivity.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46111774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-22DOI: 10.2174/2215083810666230822113646
Shaheen Akhlaq, A. Jamal, A. Siddiqui, S. Ara, Malik Itrat
The Coronavirus disease (COVID-19) impacted not only physical health but also psychological health, including anxiety, depressive symptoms, and sleep issues. Disrupted sleep has now become a global concern and burden in the post-COVID period of recovery. The Unani system of medicine elaborated on sleeping issues and their management during the pandemic. However, the claims of the Unani system and its medications in improving the various domains of sleep quality during the revival period have not been investigated. A search of electronic databases on Pub Med, Scopus, Web of Science, and CINAHL, on sleep disorders, post-COVID-19 and a manual search of Unani classical text related to sleep quality improvement methods was conducted. Recent scientific evidence has found a positive association between COVID-19 and sleep disorders. Unani medicine suggests improvement of sleep issues by maintaining six essential factors, dieto-therapy, pharmacotherapy, and regimens (like Nutool (irrigation), Hamam (Turkish bath), and Dalk (massage). Several pre-clinical and clinical trials done on Unani herbs (single and poly-herbal preparations) have elucidated the scientific rationale for improving sleep quality. Unani therapy has sufficient potential for improving sleep outcomes for COVID-19 patients as they are efficacious, safe and affordable therapeutic options. Additionally, there is still a need for evidence to support the validity of Unani psychotherapy as a multifaceted and holistic approach.
冠状病毒病(COVID-19)不仅影响身体健康，还影响心理健康，包括焦虑、抑郁症状和睡眠问题。在新冠肺炎疫情后的恢复期，睡眠中断已成为全球关注的问题和负担。Unani医学系统详细阐述了大流行期间的睡眠问题及其管理。然而，Unani系统及其药物在复苏期间改善睡眠质量的各个领域的说法尚未得到调查。检索Pub Med、Scopus、Web of Science和CINAHL的电子数据库，检索新冠肺炎后睡眠障碍的相关信息，并手动检索与睡眠质量改善方法相关的Unani经典文本。最近的科学证据发现，COVID-19与睡眠障碍之间存在正相关。Unani医学建议通过保持六个基本因素来改善睡眠问题，饮食疗法，药物疗法和养生法(如Nutool(灌溉)，Hamam(土耳其浴)和Dalk(按摩))。对乌纳尼草药(单草药和多草药制剂)进行的几项临床前和临床试验阐明了改善睡眠质量的科学依据。Unani疗法有足够的潜力改善COVID-19患者的睡眠结果，因为它们是有效、安全和负担得起的治疗选择。此外，仍然需要证据来支持Unani心理治疗作为一种多方面和整体方法的有效性。
{"title":"The Sequelae of Sleeping Issues and their Management in Post COVID-19: A Unani and Contemporary Narrative Review","authors":"Shaheen Akhlaq, A. Jamal, A. Siddiqui, S. Ara, Malik Itrat","doi":"10.2174/2215083810666230822113646","DOIUrl":"https://doi.org/10.2174/2215083810666230822113646","url":null,"abstract":"\u0000\u0000The Coronavirus disease (COVID-19) impacted not only physical health but also psychological health, including anxiety, depressive symptoms, and sleep issues. Disrupted sleep has now become a global concern and burden in the post-COVID period of recovery. The Unani system of medicine elaborated on sleeping issues and their management during the pandemic. However, the claims of the Unani system and its medications in improving the various domains of sleep quality during the revival period have not been investigated.\u0000\u0000\u0000\u0000A search of electronic databases on Pub Med, Scopus, Web of Science, and CINAHL, on sleep disorders, post-COVID-19 and a manual search of Unani classical text related to sleep quality improvement methods was conducted.\u0000\u0000\u0000\u0000Recent scientific evidence has found a positive association between COVID-19 and sleep disorders. Unani medicine suggests improvement of sleep issues by maintaining six essential factors, dieto-therapy, pharmacotherapy, and regimens (like Nutool (irrigation), Hamam (Turkish bath), and Dalk (massage). Several pre-clinical and clinical trials done on Unani herbs (single and poly-herbal preparations) have elucidated the scientific rationale for improving sleep quality.\u0000\u0000\u0000\u0000Unani therapy has sufficient potential for improving sleep outcomes for COVID-19 patients as they are efficacious, safe and affordable therapeutic options. Additionally, there is still a need for evidence to support the validity of Unani psychotherapy as a multifaceted and holistic approach.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46444003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-22DOI: 10.2174/2215083810666230822113615
P. D. Krishna, M. P. Gowrav, Mahendran Bhaskaran, M. R. Kruthika
If a herbal pharmaceutical is intended to impact the function of the human organism, it is categorized as a medication or a nutritional supplement. According to the FDA, the medicine must be offered under a New Drug Application (NDA). The European Medicine Agency (EMA) has established two methods for registering herbal medicals: Under Directive 2001/83/EC, a full marketing authorization (MA) is obtained by submitting a dossier containing data about the quality, safeness, and effectiveness of pharmaceuticals, which include physical and chemical, biological, or microbiological tests, as well as pharmacological, toxicological, and clinical trial documentation; There is a simplest technique under Directive 2004/24/EC for classical herbals that do not needs professional monitoring and where the indication of long history use of pharmaceuticals exists and appropriate relevant journals to illustrate a very well medicinal usage is not provided. A study about the regulatory status of herbal drugs/products was conducted in America and Europe to understand the various classes under which the sale of herbal goods is authorized and their premarketing criteria. This study has been performed by gathering information from the official websites of the USFDA and EMA. A thorough evaluation was carried out in order to identify the impediments to the harmonization of herbal goods. Aside from the challenges of herb supply and conservation, it has been shown that there is a lack of uniformity in the regulatory standards of herbal supplements globally. These are impeding international commerce and the expansion of the herbal goods market. USFDA classifies botanical items as pharmaceutical, nutrition, or dietary supplement based on the indications or ultimate use.
{"title":"Current regulations of Herbal medicines in the US and EU","authors":"P. D. Krishna, M. P. Gowrav, Mahendran Bhaskaran, M. R. Kruthika","doi":"10.2174/2215083810666230822113615","DOIUrl":"https://doi.org/10.2174/2215083810666230822113615","url":null,"abstract":"\u0000\u0000If a herbal pharmaceutical is intended to impact the function of the human organism, it is categorized as a medication or a nutritional supplement. According to the FDA, the medicine must be offered under a New Drug Application (NDA). The European Medicine Agency (EMA) has established two methods for registering herbal medicals: Under Directive 2001/83/EC, a full marketing authorization (MA) is obtained by submitting a dossier containing data about the quality, safeness, and effectiveness of pharmaceuticals, which include physical and chemical, biological, or microbiological tests, as well as pharmacological, toxicological, and clinical trial documentation; There is a simplest technique under Directive 2004/24/EC for classical herbals that do not needs professional monitoring and where the indication of long history use of pharmaceuticals exists and appropriate relevant journals to illustrate a very well medicinal usage is not provided.\u0000\u0000\u0000\u0000A study about the regulatory status of herbal drugs/products was conducted in America and Europe to understand the various classes under which the sale of herbal goods is authorized and their premarketing criteria.\u0000\u0000\u0000\u0000This study has been performed by gathering information from the official websites of the USFDA and EMA.\u0000\u0000\u0000\u0000A thorough evaluation was carried out in order to identify the impediments to the harmonization of herbal goods.\u0000\u0000\u0000\u0000Aside from the challenges of herb supply and conservation, it has been shown that there is a lack of uniformity in the regulatory standards of herbal supplements globally. These are impeding international commerce and the expansion of the herbal goods market. USFDA classifies botanical items as pharmaceutical, nutrition, or dietary supplement based on the indications or ultimate use.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46792496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-18DOI: 10.2174/2215083810666230818092940
J. Dwivedi, Pranjal Sachan, P. Wal, A. Rai
One of the most popular beekeeping products is propolis. The word "propolis," which alludes to a beehive, has Greek sources and implies "defense for the community." Propolis is a resinous material that honey worker bees (Apis mellifera L.) and other bee species make for a variety of uses. Since 300 BC, propolis has been used as a traditional remedy. Various pharmacological effects of distinct propolis extracts as well as those of its ingredients, including antioxidant, antiulcer, anticancer, antiviral, anti-microbial, anti-inflammatory, and antifungal characteristics, have recently been identified. In this review article, we focus on the origin, recent advances in the chemical constituents, and new therapeutic potential of propolis. An exhaustive analysis of the literature search was conducted. The standard keywords "propolis," "origin," "chemical constituents," "pharmacological activity," "recent advances," and "traditional uses" have been used to search a variety of the standard databases, such as Scopus and Elsevier, PubMed, ScienceDirect, and Science Web, for research and review articles published between 1998 and 2023. This review article included over 150 articles (research and reviews) that were appraised and researched. Since 2012, more than 300 substances have been shown to have pharmacological action against a variety of illnesses, including cancer, inflammation, ulcers, wound healing, diabetes, bacterial, viral, and fungal infections, hepatic disorders, dental problems, brain diseases, etc. Overall, propolis may be considered a source of bioactive compounds for pharmaceutical development. Future studies should consider plant types, regional conditions, bee subspecies, and variations.
{"title":"In-depth chemistry and pharmacological potential of Propolis: A critical review of recent developments","authors":"J. Dwivedi, Pranjal Sachan, P. Wal, A. Rai","doi":"10.2174/2215083810666230818092940","DOIUrl":"https://doi.org/10.2174/2215083810666230818092940","url":null,"abstract":"\u0000\u0000One of the most popular beekeeping products is propolis. The word \"propolis,\" which alludes to a beehive, has Greek sources and implies \"defense for the community.\" Propolis is a resinous material that honey worker bees (Apis mellifera L.) and other bee species make for a variety of uses. Since 300 BC, propolis has been used as a traditional remedy. Various pharmacological effects of distinct propolis extracts as well as those of its ingredients, including antioxidant, antiulcer, anticancer, antiviral, anti-microbial, anti-inflammatory, and antifungal characteristics, have recently been identified.\u0000\u0000\u0000\u0000In this review article, we focus on the origin, recent advances in the chemical constituents, and new therapeutic potential of propolis.\u0000\u0000\u0000\u0000An exhaustive analysis of the literature search was conducted. The standard keywords \"propolis,\" \"origin,\" \"chemical constituents,\" \"pharmacological activity,\" \"recent advances,\" and \"traditional uses\" have been used to search a variety of the standard databases, such as Scopus and Elsevier, PubMed, ScienceDirect, and Science Web, for research and review articles published between 1998 and 2023.\u0000\u0000\u0000\u0000This review article included over 150 articles (research and reviews) that were appraised and researched.\u0000\u0000\u0000\u0000Since 2012, more than 300 substances have been shown to have pharmacological action against a variety of illnesses, including cancer, inflammation, ulcers, wound healing, diabetes, bacterial, viral, and fungal infections, hepatic disorders, dental problems, brain diseases, etc. Overall, propolis may be considered a source of bioactive compounds for pharmaceutical development. Future studies should consider plant types, regional conditions, bee subspecies, and variations.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41650375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-18DOI: 10.2174/2215083810666230818092559
Shreyasi Karmakar, Urvashee Gogoi, Riya Saikia, Aparoop Das
A wide variety of Garcinia species have been used over decades, as traditional home remedies starting from their use in flavored food to the treatment of various ailments. The presence of the essential primary and secondary metabolite with curative properties in Garcinia has enhanced its value in the therapeutic world. These have captivated the use of Garcinia in expanding nutritional values and adding extra health benefits. Hereby, observing the potential of different Garcinia species for their use as nutraceuticals. The present-day lifestyle and current health trends are the reasons why the public has accumulated a lot of interest in the nutraceutical food market. Traditionally the various remedies used from plants, fruits, and fruit extracts used in the cure of multiple ailments since antiquity have now made their way into pharmaceutical nutraceuticals. The fruits of Garcinia species have many culinary, nutritional, and pharmaceutical uses. Therefore, the paper aims to focus on the different Garcinia species having nutritional potential along with various therapeutic properties. Studies of different Garcinia species are reviewed, with a focus on their nutritional and medicinal actions on ailments that are the reason for today's lifestyles and current health trends. Different varieties of Garcinia species are found to have various potential primary and secondary metabolites which have curative properties like anti-diabetic, anti-obesity, anti-microbial, anti-cancer, anti-inflammation, and anti-bacterial potential. The natural occurrences of the plant product with nutraceutical value have boosted the quality of life. The Garcinia species containing the essential primary and secondary constituents are accountable for numerous biological activities. Many of the Garcinia species are marketed these days for a better and healthy life. Thus, Garcinia could be used as a nutraceutical to alleviate several disease conditions.
{"title":"Insight into the nutraceutical potential of garcinia species","authors":"Shreyasi Karmakar, Urvashee Gogoi, Riya Saikia, Aparoop Das","doi":"10.2174/2215083810666230818092559","DOIUrl":"https://doi.org/10.2174/2215083810666230818092559","url":null,"abstract":"\u0000\u0000A wide variety of Garcinia species have been used over decades, as traditional home remedies starting from their use in flavored food to the treatment of various ailments. The presence of the essential primary and secondary metabolite with curative properties in Garcinia has enhanced its value in the therapeutic world. These have captivated the use of Garcinia in expanding nutritional values and adding extra health benefits. Hereby, observing the potential of different Garcinia species for their use as nutraceuticals.\u0000\u0000\u0000\u0000The present-day lifestyle and current health trends are the reasons why the public has accumulated a lot of interest in the nutraceutical food market. Traditionally the various remedies used from plants, fruits, and fruit extracts used in the cure of multiple ailments since antiquity have now made their way into pharmaceutical nutraceuticals. The fruits of Garcinia species have many culinary, nutritional, and pharmaceutical uses. Therefore, the paper aims to focus on the different Garcinia species having nutritional potential along with various therapeutic properties.\u0000\u0000\u0000\u0000Studies of different Garcinia species are reviewed, with a focus on their nutritional and medicinal actions on ailments that are the reason for today's lifestyles and current health trends.\u0000\u0000\u0000\u0000Different varieties of Garcinia species are found to have various potential primary and secondary metabolites which have curative properties like anti-diabetic, anti-obesity, anti-microbial, anti-cancer, anti-inflammation, and anti-bacterial potential.\u0000\u0000\u0000\u0000The natural occurrences of the plant product with nutraceutical value have boosted the quality of life. The Garcinia species containing the essential primary and secondary constituents are accountable for numerous biological activities. Many of the Garcinia species are marketed these days for a better and healthy life. Thus, Garcinia could be used as a nutraceutical to alleviate several disease conditions.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48034861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-16DOI: 10.2174/2215083810666230816095403
Amal Mayyas, T. Aburjai, L. Abu-Qatouseh, Mohammad Abu Sini, Rula A Amr, Rand T. Akasheh, N. Alrabadi, R. Darwish
This study was designed to evaluate the antimicrobial activity of some medicinal plants used among Jordanians for the treatment of gastritis and gastric ulcers against H. pylori. Moreover, plants' inhibitory activity against the H. pylori urease enzyme was also evaluated. The activity of 11 medicinal plants used by common people and herbalists to treat ulcers was evaluated against H. pylori (NCTC 11916). Ethanol and essential oil extracts from the tested plants were evaluated using a standard agar dilution method and the MICs were determined. Furthermore, the potential inhibitory effect of each preparation was tested against the enzyme urease using a kinetic colorimetric assay. Cinnamomum cassia oil showed the highest efficiency against H. pylori with the lowest MIC (0.0122 mg.mL-1), followed by Origanum syriacum and Foeniculum vulgare (MICs of 0.39 mg.mL-1). Furthermore, significant urease inhibition activity was recorded for Carum carvi oil (IC50~0.45 mg.mL-1). C. cassia oil (IC50 ~2.8 mg.mL-1), Aloysia citriodora, and Artemisia Judaica (IC50 5.8 mg.mL-1) reported potential urease inhibition activities. Herbs used in Jordanian traditional medicine were found to have anti-H. pylori and significant urease inhibitory activity. These findings might support the use of medicinal plants as adjuvant or alternative therapy for the treatment of H. pylori.
{"title":"Fighting H. pylori with Medicinal Plants: A Study on Jordan's Traditional Remedies","authors":"Amal Mayyas, T. Aburjai, L. Abu-Qatouseh, Mohammad Abu Sini, Rula A Amr, Rand T. Akasheh, N. Alrabadi, R. Darwish","doi":"10.2174/2215083810666230816095403","DOIUrl":"https://doi.org/10.2174/2215083810666230816095403","url":null,"abstract":"\u0000\u0000This study was designed to evaluate the antimicrobial activity of some medicinal plants used among Jordanians for the treatment of gastritis and gastric ulcers against H. pylori. Moreover, plants' inhibitory activity against the H. pylori urease enzyme was also evaluated.\u0000\u0000\u0000\u0000The activity of 11 medicinal plants used by common people and herbalists to treat ulcers was evaluated against H. pylori (NCTC 11916). Ethanol and essential oil extracts from the tested plants were evaluated using a standard agar dilution method and the MICs were determined. Furthermore, the potential inhibitory effect of each preparation was tested against the enzyme urease using a kinetic colorimetric assay.\u0000\u0000\u0000\u0000Cinnamomum cassia oil showed the highest efficiency against H. pylori with the lowest MIC (0.0122 mg.mL-1), followed by Origanum syriacum and Foeniculum vulgare (MICs of 0.39 mg.mL-1). Furthermore, significant urease inhibition activity was recorded for Carum carvi oil (IC50~0.45 mg.mL-1). C. cassia oil (IC50 ~2.8 mg.mL-1), Aloysia citriodora, and Artemisia Judaica (IC50 5.8 mg.mL-1) reported potential urease inhibition activities.\u0000\u0000\u0000\u0000Herbs used in Jordanian traditional medicine were found to have anti-H. pylori and significant urease inhibitory activity. These findings might support the use of medicinal plants as adjuvant or alternative therapy for the treatment of H. pylori.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43655694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-16DOI: 10.2174/2215083810666230816095313
Shilpi Pathak, Riya Verma, Richa Sharma
Since childhood, plants and plant products have been used extensively as medicine. The majority of rural residents still rely on natural resources and the old-fashioned medical system for their daily needs. The biological richness of Arunachal Pradesh is renowned, as is its rich cultural diversity. The native population uses a number of aromatic and medicinal plant species to cure a wide range of illnesses. The current review deals with the biological activity of Stemona tuberosa, a possible medicinal plant species of Arunachal Pradesh. Extract from tuberous roots has numerous properties, including anti-bacterial, anti-inflammatory, anti-tobacco mosaic virus, antitussive, wound healing, and anti-herpes. The roots' powder is employed as a preservation and insect deterrent. Alkaloids, sugars and glycosides, phenolic compounds, trace amounts of proteins, saponin, flavonoids, and gum mucilage, were all found during the phytochemical analysis, which shows that the species has a significant potential for therapeutic use. As a result, it is possible to think of the examined species as a potential source of beneficial medications.
{"title":"Pharmacological Activities of the Roots of Stemona tuberosa Medicinal Plant: An Overview","authors":"Shilpi Pathak, Riya Verma, Richa Sharma","doi":"10.2174/2215083810666230816095313","DOIUrl":"https://doi.org/10.2174/2215083810666230816095313","url":null,"abstract":"\u0000\u0000Since childhood, plants and plant products have been used extensively as medicine. The majority of rural residents still rely on natural resources and the old-fashioned medical system for their daily needs. The biological richness of Arunachal Pradesh is renowned, as is its rich cultural diversity. The native population uses a number of aromatic and medicinal plant species to cure a wide range of illnesses. The current review deals with the biological activity of Stemona tuberosa, a possible medicinal plant species of Arunachal Pradesh. Extract from tuberous roots has numerous properties, including anti-bacterial, anti-inflammatory, anti-tobacco mosaic virus, antitussive, wound healing, and anti-herpes. The roots' powder is employed as a preservation and insect deterrent. Alkaloids, sugars and glycosides, phenolic compounds, trace amounts of proteins, saponin, flavonoids, and gum mucilage, were all found during the phytochemical analysis, which shows that the species has a significant potential for therapeutic use. As a result, it is possible to think of the examined species as a potential source of beneficial medications.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43861129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.2174/2215083810666230815142547
A. Dhingra, M. Chopra, Geeta Deswal, B. Chopra, P. Kriplani, R. Dass, A. Grewal, V. Rathi
The plant Terminalia chebula has been used traditionally in many regions of the world for its therapeutic properties, especially in India. Its therapeutic and health-promoting potential has been recognized for centuries, and modern research continues to unveil its numerous benefits. One of the most significant applications of this plant is its antimicrobial and antioxidant potential. The plant contains high levels of phenolic compounds and flavonoids, which scavenge harmful free radicals in the body, reducing oxidative stress and cellular damage. This antioxidant action contributes to its anti-inflammatory effects, making it beneficial for a wide range of conditions, including arthritis, cardiovascular diseases, and neurodegenerative disorders. Furthermore, Terminalia chebula exhibits antimicrobial activity against various bacteria and fungi, including those responsible for common infections. It has been used to treat respiratory infections, urinary tract infections, and skin ailments. Its broad-spectrum antimicrobial effects make it a valuable natural remedy for combating microbial pathogens. Moreover, Terminalia chebula shows potential in managing diabetes and promoting cardiovascular health. Studies have indicated its ability to regulate blood sugar levels, improve insulin sensitivity, and reduce lipid abnormalities. These properties make it a promising adjunct therapy for individuals with diabetes or at risk of heart disease. In conclusion, Terminalia chebula possesses remarkable therapeutic and health-promoting potential. Its antioxidant, anti-inflammatory, antimicrobial, and digestive benefits make it a valuable natural remedy for various ailments. While research on Terminalia chebula is ongoing, its long-standing use in traditional medicine and emerging scientific evidence solidify its status as a potent medicinal plant with diverse applications in promoting overall well-being.
{"title":"Therapeutic and Health Promoting Potential of Terminalia chebula: An Exploratory Literature Review","authors":"A. Dhingra, M. Chopra, Geeta Deswal, B. Chopra, P. Kriplani, R. Dass, A. Grewal, V. Rathi","doi":"10.2174/2215083810666230815142547","DOIUrl":"https://doi.org/10.2174/2215083810666230815142547","url":null,"abstract":"\u0000\u0000The plant Terminalia chebula has been used traditionally in many regions of the world for its therapeutic properties, especially in India. Its therapeutic and health-promoting potential has been recognized for centuries, and modern research continues to unveil its numerous benefits. One of the most significant applications of this plant is its antimicrobial and antioxidant potential. The plant contains high levels of phenolic compounds and flavonoids, which scavenge harmful free radicals in the body, reducing oxidative stress and cellular damage. This antioxidant action contributes to its anti-inflammatory effects, making it beneficial for a wide range of conditions, including arthritis, cardiovascular diseases, and neurodegenerative disorders. Furthermore, Terminalia chebula exhibits antimicrobial activity against various bacteria and fungi, including those responsible for common infections. It has been used to treat respiratory infections, urinary tract infections, and skin ailments. Its broad-spectrum antimicrobial effects make it a valuable natural remedy for combating microbial pathogens. Moreover, Terminalia chebula shows potential in managing diabetes and promoting cardiovascular health. Studies have indicated its ability to regulate blood sugar levels, improve insulin sensitivity, and reduce lipid abnormalities. These properties make it a promising adjunct therapy for individuals with diabetes or at risk of heart disease. In conclusion, Terminalia chebula possesses remarkable therapeutic and health-promoting potential. Its antioxidant, anti-inflammatory, antimicrobial, and digestive benefits make it a valuable natural remedy for various ailments. While research on Terminalia chebula is ongoing, its long-standing use in traditional medicine and emerging scientific evidence solidify its status as a potent medicinal plant with diverse applications in promoting overall well-being.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44740401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.2174/2215083810666230815142928
H. Motedayyen, Tayebe Pouryousefi-koodehi, M. S. Kahrizi, Hossein Roghani-Shahraki, Fatemeh Rezaei-Tazangi, Reza Arefnezhad
Prostate cancer (PCa) is known as the fifth reason for cancer-related deaths and involves a considerable population of men globally. In PCa, pluriform neoplasm with different cancer patterns is formed. Metastases have a substantial role in disease mortality, and lung, liver, and bone are among the common organs for metastasis. In spite of multiple attempts by researchers, it has not been recommended a safe and suitable approach against PCa so far. Fortunately, herbal remedies have opened a novel window in order to treat several cancers, such as PCa; however, there are some barriers regarding this curative method, like low bioavailability and absorption and low water solubility. On the contrary, some nano-based formulations have revealed a potential ability to overcome these limitations, and it seems that the co-use of herbal products and nanoformulations provides a good opportunity for treating PCa. In this study, we argued about the therapeutic aspects of some nanoformulations of popular herbal products, such as curcumin, quercetin, and resveratrol, against PCa.
{"title":"Nano-based herbal medicine: A new candidate for prostate cancer treatment?","authors":"H. Motedayyen, Tayebe Pouryousefi-koodehi, M. S. Kahrizi, Hossein Roghani-Shahraki, Fatemeh Rezaei-Tazangi, Reza Arefnezhad","doi":"10.2174/2215083810666230815142928","DOIUrl":"https://doi.org/10.2174/2215083810666230815142928","url":null,"abstract":"\u0000\u0000Prostate cancer (PCa) is known as the fifth reason for cancer-related deaths and involves a considerable population of men globally. In PCa, pluriform neoplasm with different cancer patterns is formed. Metastases have a substantial role in disease mortality, and lung, liver, and bone are among the common organs for metastasis. In spite of multiple attempts by researchers, it has not been recommended a safe and suitable approach against PCa so far.\u0000\u0000\u0000\u0000Fortunately, herbal remedies have opened a novel window in order to treat several cancers, such as PCa; however, there are some barriers regarding this curative method, like low bioavailability and absorption and low water solubility. On the contrary, some nano-based formulations have revealed a potential ability to overcome these limitations, and it seems that the co-use of herbal products and nanoformulations provides a good opportunity for treating PCa.\u0000\u0000\u0000\u0000In this study, we argued about the therapeutic aspects of some nanoformulations of popular herbal products, such as curcumin, quercetin, and resveratrol, against PCa.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42919133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-10DOI: 10.2174/2215083810666230810094713
Ganguly Paramita, Kazi Julekha, Mandal Sudip kumar
Dental caries is one of the Periodontal diseases that has been recognized as a major public health problem for decades throughout the world. It occurs in all groups, ethnicities, races, and genders at all socioeconomic levels. Natural remedies are more acceptable in the belief that they are safer with fewer side effects than synthetic ones. Clove and coriander oil are established herbal drugs for periodontal diseases. This research work was intended to formulate a dental gel containing clove and Coriander as the major constituents and evaluate it for dental caries treatment. Both of the herbal oils have a vast range of antimicrobial activity against a great number of periodontal pathogens; therefore, they are used for periodontitis treatment. The combination gel was prepared using carbopol 934 as a gelling agent, clove oil and coriander oil as therapeutic constituents, polyethylene glycol as a co-solvent, methyl paraben and propyl paraben as a preservative and a required quantity of distilled water as vehicle. The gel was analyzed for various properties like antimicrobial activity, pH, spreadability, extrudability, drug content etc., and it was shown that the combination gel is a satisfactory dosage form that is used in periodontitis treatment. The combination gel revealed the ZI ( zone of inhibition ) of about 22.05±0.04 mm. The present study concluded that the combination gel preparations of clove oil and coriander oil reported satisfactory physicochemical properties along with good drug content compared to the single gel preparation.
{"title":"Formulation and Development of Clove and Coriander Combination Herbal Dental Anticaries Gel and Evaluation of its Antimicrobial Activity","authors":"Ganguly Paramita, Kazi Julekha, Mandal Sudip kumar","doi":"10.2174/2215083810666230810094713","DOIUrl":"https://doi.org/10.2174/2215083810666230810094713","url":null,"abstract":"\u0000\u0000Dental caries is one of the Periodontal diseases that has been recognized as a major public health problem for decades throughout the world. It occurs in all groups, ethnicities, races, and genders at all socioeconomic levels. Natural remedies are more acceptable in the belief that they are safer with fewer side effects than synthetic ones. Clove and coriander oil are established herbal drugs for periodontal diseases.\u0000\u0000\u0000\u0000This research work was intended to formulate a dental gel containing clove and Coriander as the major constituents and evaluate it for dental caries treatment. Both of the herbal oils have a vast range of antimicrobial activity against a great number of periodontal pathogens; therefore, they are used for periodontitis treatment.\u0000\u0000\u0000\u0000The combination gel was prepared using carbopol 934 as a gelling agent, clove oil and coriander oil as therapeutic constituents, polyethylene glycol as a co-solvent, methyl paraben and propyl paraben as a preservative and a required quantity of distilled water as vehicle.\u0000\u0000\u0000\u0000The gel was analyzed for various properties like antimicrobial activity, pH, spreadability, extrudability, drug content etc., and it was shown that the combination gel is a satisfactory dosage form that is used in periodontitis treatment. The combination gel revealed the ZI ( zone of inhibition ) of about 22.05±0.04 mm.\u0000\u0000\u0000\u0000The present study concluded that the combination gel preparations of clove oil and coriander oil reported satisfactory physicochemical properties along with good drug content compared to the single gel preparation.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42542845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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