Pub Date : 2023-10-11DOI: 10.2174/0122150838266844230927052225
Prashant L. Pingale, Rupali A. Patil, Anjali P. Bedse, Shilpa S. Raut
Abstract: Recently nanotechnology has emerged with more attention to the cosmetic industry. Formulations for skin whitening are widely applied but hyperpigmentation treatment remains unnoticed. This review summarises use of nanotechnology in hyperpimentaion. Various organic and inorganic nanoparticles used in cosmeceuticals are explained. Various approaches for treatment of hyperpigmentation, barriers for Nanodelivery, availability of organic and inorganic synthetic nanoparticles are stated in the study. The advantages and disadvantages of these organic and inorganic compounds are enlisted. Special emphasis has been given to natural substances including arbutin, Aloesin, hesperidin, niacinamide, liquorice, mulberry, polyphenols, ginseng, gingko which are used used in hyperpigmentation. Regulatory challenges and issues for clinical translation, Patents and publications available in last 20 years related to nanotechnology in hyperpigmentation are discussed in brief. It has been observed that amongst nanocosmeceuticals used for hyperpigmentation, lipid nanoparticles are most widely used due to more skin permeability, biocompatibility, and biodegradable nature. Nonetheless, investigation on health effects and safety profile of nanomaterials are essential for understanding the impact of using these materials.
{"title":"Natural Nanoparticulate Cosmeceuticals: Boon for Hyperpigmentation","authors":"Prashant L. Pingale, Rupali A. Patil, Anjali P. Bedse, Shilpa S. Raut","doi":"10.2174/0122150838266844230927052225","DOIUrl":"https://doi.org/10.2174/0122150838266844230927052225","url":null,"abstract":"Abstract: Recently nanotechnology has emerged with more attention to the cosmetic industry. Formulations for skin whitening are widely applied but hyperpigmentation treatment remains unnoticed. This review summarises use of nanotechnology in hyperpimentaion. Various organic and inorganic nanoparticles used in cosmeceuticals are explained. Various approaches for treatment of hyperpigmentation, barriers for Nanodelivery, availability of organic and inorganic synthetic nanoparticles are stated in the study. The advantages and disadvantages of these organic and inorganic compounds are enlisted. Special emphasis has been given to natural substances including arbutin, Aloesin, hesperidin, niacinamide, liquorice, mulberry, polyphenols, ginseng, gingko which are used used in hyperpigmentation. Regulatory challenges and issues for clinical translation, Patents and publications available in last 20 years related to nanotechnology in hyperpigmentation are discussed in brief. It has been observed that amongst nanocosmeceuticals used for hyperpigmentation, lipid nanoparticles are most widely used due to more skin permeability, biocompatibility, and biodegradable nature. Nonetheless, investigation on health effects and safety profile of nanomaterials are essential for understanding the impact of using these materials.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"255 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136213371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract: COVID-19, or SARS-CoV-2 or novel coronavirus 2019 (nCoV-2019), first reported in Wuhan, China, has become a global pandemic due to human-to-human transmission with no specific treatment available. This review highlights the history of coronavirus, its diagnosis, treatment, and prevention by immunity-modulating Ayurvedic interventions to manage the disease during the early chaotic days of the COVID-19 outburst. Immunity modulation is a documented mode of action for many Ayurvedic drugs, including Tinospora cordifolia, Withania somnifera, Andrographis paniculata, Glycerrhiza glabra, Boerhaevia diffusa, Ocimum sanctum, Tribulus terrestris, Curcuma longa, Emblica officinalis, Terminalia chebula, Terminalia bellirica, etc. Several studies have been performed, and many trials have been registered to evaluate the effects of these herbal drugs to combat infectious diseases like COVID-19. Studies have also shown that Ayurvedic drugs, healthy diet, good lifestyle, and psychological aspects all have been researched over the years and found to have a significant role in increasing immunity and decreasing the number of comorbidities; hence, they should be considered in designing a module for the prevention and treatment of COVID-19 infection.
{"title":"Management of COVID-19 Pandemic by Immunity-modulating Ayurvedic Interventions: A Bright Panacea","authors":"Ruchi Sharma, Shalini Rai, Heena Saini, Dimpal Rochlani, Varnika Singh, Richa Tripathi","doi":"10.2174/0122150838262609231003071619","DOIUrl":"https://doi.org/10.2174/0122150838262609231003071619","url":null,"abstract":"Abstract: COVID-19, or SARS-CoV-2 or novel coronavirus 2019 (nCoV-2019), first reported in Wuhan, China, has become a global pandemic due to human-to-human transmission with no specific treatment available. This review highlights the history of coronavirus, its diagnosis, treatment, and prevention by immunity-modulating Ayurvedic interventions to manage the disease during the early chaotic days of the COVID-19 outburst. Immunity modulation is a documented mode of action for many Ayurvedic drugs, including Tinospora cordifolia, Withania somnifera, Andrographis paniculata, Glycerrhiza glabra, Boerhaevia diffusa, Ocimum sanctum, Tribulus terrestris, Curcuma longa, Emblica officinalis, Terminalia chebula, Terminalia bellirica, etc. Several studies have been performed, and many trials have been registered to evaluate the effects of these herbal drugs to combat infectious diseases like COVID-19. Studies have also shown that Ayurvedic drugs, healthy diet, good lifestyle, and psychological aspects all have been researched over the years and found to have a significant role in increasing immunity and decreasing the number of comorbidities; hence, they should be considered in designing a module for the prevention and treatment of COVID-19 infection.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"255 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136213246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-11DOI: 10.2174/0122150838260749230926072326
Disha Arora, Smriti Parashar, Rupesh K. Gautam, Rajat Goyal
Nature has always been a wonderful supply of therapeutic substances, providing us with a range of medicinal plants that produce helpful phytochemicals. The native species of the genus Echinacea, which are found in North America and are well-known among medicinal plants, are members of the Asteraceae family. Though there are nine different species of echinacea, only three Echinacea angustifolia DC, Echinacea purpurea (L.) Moench, and Echinacea pallida (Nutt.)-are utilized as medicinal herbs with a variety of therapeutic uses. Contrary to other plant families, the Asteraceae family of plants is one of the most well-known and renowned, and as a result, many of its members have been employed for therapeutic purposes. The availability of substances with a variety of medicinal characteristics is to blame for this. This review has included the investigation of the morphological traits, ethnopharmacology, and diverse pharmacological properties of the Echinacea genus. The chemistry of the genus is extensively understood, and various chemical component groups-including alkamides and caffeic acid derivatives-are believed to be crucial for activity.
{"title":"Phytochemical, Ethnobotanical, and Global Perspectives of Genus Echinacea: A Panoramic Review","authors":"Disha Arora, Smriti Parashar, Rupesh K. Gautam, Rajat Goyal","doi":"10.2174/0122150838260749230926072326","DOIUrl":"https://doi.org/10.2174/0122150838260749230926072326","url":null,"abstract":"Nature has always been a wonderful supply of therapeutic substances, providing us\u0000with a range of medicinal plants that produce helpful phytochemicals. The native species of the\u0000genus Echinacea, which are found in North America and are well-known among medicinal\u0000plants, are members of the Asteraceae family. Though there are nine different species of echinacea, only three Echinacea angustifolia DC, Echinacea purpurea (L.) Moench, and Echinacea\u0000pallida (Nutt.)-are utilized as medicinal herbs with a variety of therapeutic uses. Contrary to other plant families, the Asteraceae family of plants is one of the most well-known and renowned,\u0000and as a result, many of its members have been employed for therapeutic purposes. The availability of substances with a variety of medicinal characteristics is to blame for this. This review\u0000has included the investigation of the morphological traits, ethnopharmacology, and diverse\u0000pharmacological properties of the Echinacea genus. The chemistry of the genus is extensively\u0000understood, and various chemical component groups-including alkamides and caffeic acid derivatives-are believed to be crucial for activity.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136213370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Plants have long been utilised as a supplement or alternative treatment for chronic conditions due to their therapeutic capabilities. Objectives: The objective of this study is to explore the ethnopharmacological aspects and therapeutic potential of naturally occurring oleanolic acid. Method: Information regarding oleanolic acid was collected from electronic databases, such as ScienceDirect, Web of Science, PubMed, Springer, Journal websites, Google Scholar, Taylor and Francis, Scopus and Wiley Online Library. Result: The article covered a wide range of immunomodulatory, antihypertensive, anticancer, antiinflammatory, antianxiety, antidepressant, antiischemic, antiviral, and other effects of triterpenoids. One such triterpenoid is oleanolic acid, which was reported to be present in a number of plants with a wide range of pharmacological potential. This article discussed the promising possibilities for alternative neurodegenerative disease treatment and management through oleanolic acid and its derivatives. Conclusion: The goal of this systematic review was to review the medicinal importance of oleanolic acid, extracted from a variety of plants used as a dietary source, such as apple, pomegranate, lemon, grapes, pears, olive, a highly powerful molecule with a wide range of biological actions, such as anti-microbial, anti-viral, anti-diabetic, hepatoprotective, antihypertensive, antiinflammatory, anticancer, anti-ischemic, antiviral, and cytotoxic properties.
植物长期以来一直被用作慢性疾病的补充或替代治疗，因为它们的治疗能力。目的:本研究的目的是探索天然齐墩果酸的民族药理学方面和治疗潜力。方法:从ScienceDirect、Web of Science、PubMed、Springer、Journal websites、Google Scholar、Taylor and Francis、Scopus和Wiley Online Library等电子数据库收集齐墩果酸相关信息。结果:三萜具有广泛的免疫调节、降压、抗癌、抗炎、抗焦虑、抗抑郁、抗缺血、抗病毒等作用。齐墩果酸就是这样一种三萜，据报道，齐墩果酸存在于许多植物中，具有广泛的药理潜力。本文讨论了齐墩果酸及其衍生物治疗和管理神经退行性疾病的可能性。结论:本系统综述的目的是回顾齐墩果酸的药用价值，它是从多种植物中提取的，如苹果、石榴、柠檬、葡萄、梨、橄榄等，是一种具有广泛生物作用的强效分子，如抗微生物、抗病毒、抗糖尿病、保肝、抗高血压、抗炎、抗癌、抗缺血、抗病毒和细胞毒性。
{"title":"Ethnopharmacological Insights on Therapeutic Potential of Oleanolic Acid: A Review","authors":"None Hemlata, Neeru Vasudeva, Sunil Sharma, Archana Kapoor","doi":"10.2174/2215083810666230914165353","DOIUrl":"https://doi.org/10.2174/2215083810666230914165353","url":null,"abstract":"Introduction: Plants have long been utilised as a supplement or alternative treatment for chronic conditions due to their therapeutic capabilities. Objectives: The objective of this study is to explore the ethnopharmacological aspects and therapeutic potential of naturally occurring oleanolic acid. Method: Information regarding oleanolic acid was collected from electronic databases, such as ScienceDirect, Web of Science, PubMed, Springer, Journal websites, Google Scholar, Taylor and Francis, Scopus and Wiley Online Library. Result: The article covered a wide range of immunomodulatory, antihypertensive, anticancer, antiinflammatory, antianxiety, antidepressant, antiischemic, antiviral, and other effects of triterpenoids. One such triterpenoid is oleanolic acid, which was reported to be present in a number of plants with a wide range of pharmacological potential. This article discussed the promising possibilities for alternative neurodegenerative disease treatment and management through oleanolic acid and its derivatives. Conclusion: The goal of this systematic review was to review the medicinal importance of oleanolic acid, extracted from a variety of plants used as a dietary source, such as apple, pomegranate, lemon, grapes, pears, olive, a highly powerful molecule with a wide range of biological actions, such as anti-microbial, anti-viral, anti-diabetic, hepatoprotective, antihypertensive, antiinflammatory, anticancer, anti-ischemic, antiviral, and cytotoxic properties.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136254753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract: The "lipstick tree" is another name for the ornamental plant Bixa orellana L., which is indigenous to South and Central America, the Caribbean Islands, and other regions of Asia. The plant, also known as "Sinduri" or "Latkan," is utilized in India's food, dye, cosmetics, and traditional medicine sectors. Commercially, the plant seeds are significant because they yield bixin, a carotenoid that colours dairy products and is used to manufacture "sindur" and "lipstick." The primary substances present in various portions of this plant include carotenoids, apo carotenoids, terpenes, terpenoids, sterols, and aliphatic chemicals. The various plant parts exhibit a variety of possible health advantages, including antibacterial, anti-hyperglycemic, anti-histaminic, anti-diarrheal, anti-cancer, anti-inflammatory, and antioxidant qualities. The current study provides an overview of Bixa orellana L.
{"title":"Phytochemical Mapping to Comprehend the Bioactivity of Bixa orellana L.","authors":"Mamta Thakur, Rashmi Saxena Pal, Yogendra Pal, MVNL Chaitanya","doi":"10.2174/0122150838261199230925055621","DOIUrl":"https://doi.org/10.2174/0122150838261199230925055621","url":null,"abstract":"Abstract: The \"lipstick tree\" is another name for the ornamental plant Bixa orellana L., which is indigenous to South and Central America, the Caribbean Islands, and other regions of Asia. The plant, also known as \"Sinduri\" or \"Latkan,\" is utilized in India's food, dye, cosmetics, and traditional medicine sectors. Commercially, the plant seeds are significant because they yield bixin, a carotenoid that colours dairy products and is used to manufacture \"sindur\" and \"lipstick.\" The primary substances present in various portions of this plant include carotenoids, apo carotenoids, terpenes, terpenoids, sterols, and aliphatic chemicals. The various plant parts exhibit a variety of possible health advantages, including antibacterial, anti-hyperglycemic, anti-histaminic, anti-diarrheal, anti-cancer, anti-inflammatory, and antioxidant qualities. The current study provides an overview of Bixa orellana L.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136358651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background:: According to the Global Burden of Disease (GBD) study, the global health impact of neurological and psychiatric disorders has been underestimated for years. Neuropsychiatric disorders are now recognised as significant threats to public health. In conjunction with modern pharmaceutical interventions, the clinical application of yoga and meditation techniques has been increasingly recognised for their efficacy in treating various mental health conditions. Objective:: This article aimed to provide a comprehensive review summarizing the influence of yoga and meditation on the human brain, specifically focusing on their clinical implementation for neurological and psychiatric disorders. Methods:: A systematic search was conducted across PubMed and Google Scholar databases utilizing diverse combinations of keywords, including yoga, meditation, neurogenesis, neurological disorder, mental health, mindfulness, thought process, neuroimaging, and brain, to identify pertinent literature for this review. Results:: Prevalent neurological and psychiatric ailments in our society encompass multiple sclerosis, epilepsy, migraine, fibromyalgia, cerebrovascular disease, Alzheimer's disease, major depression, anxiety disorder, and chronic stress. Scientifically corroborated by clinical studies, the advantageous effects of yoga and spiritual practices on these disorders have been substantiated. As our understanding of the complex psychology and functionalities of the human brain progresses, it becomes apparent that yoga and meditation facilitate neurogenesis and restore chemical equilibrium. Such practices aid in dispelling intrusive thoughts, negating negative emotions, and ameliorating stress, thereby offering relief to patients and progressively diminishing their reliance on conventional medication. Conclusion:: The integration of yoga and spiritual practices as complementary and non-invasive adjunctive therapies represents a promising approach to addressing the spectrum of neurological disorders plaguing modern society.
{"title":"Yoga and Meditation in the Treatment of Neurological and Psychiatric Disorders","authors":"Debabrata Ghosh Dastidar, Payel Bhattacharjee, Pratyush Das, Bachaspati Jana, Anirban Bhunia","doi":"10.2174/0122150838246321231003015837","DOIUrl":"https://doi.org/10.2174/0122150838246321231003015837","url":null,"abstract":"Background:: According to the Global Burden of Disease (GBD) study, the global health impact of neurological and psychiatric disorders has been underestimated for years. Neuropsychiatric disorders are now recognised as significant threats to public health. In conjunction with modern pharmaceutical interventions, the clinical application of yoga and meditation techniques has been increasingly recognised for their efficacy in treating various mental health conditions. Objective:: This article aimed to provide a comprehensive review summarizing the influence of yoga and meditation on the human brain, specifically focusing on their clinical implementation for neurological and psychiatric disorders. Methods:: A systematic search was conducted across PubMed and Google Scholar databases utilizing diverse combinations of keywords, including yoga, meditation, neurogenesis, neurological disorder, mental health, mindfulness, thought process, neuroimaging, and brain, to identify pertinent literature for this review. Results:: Prevalent neurological and psychiatric ailments in our society encompass multiple sclerosis, epilepsy, migraine, fibromyalgia, cerebrovascular disease, Alzheimer's disease, major depression, anxiety disorder, and chronic stress. Scientifically corroborated by clinical studies, the advantageous effects of yoga and spiritual practices on these disorders have been substantiated. As our understanding of the complex psychology and functionalities of the human brain progresses, it becomes apparent that yoga and meditation facilitate neurogenesis and restore chemical equilibrium. Such practices aid in dispelling intrusive thoughts, negating negative emotions, and ameliorating stress, thereby offering relief to patients and progressively diminishing their reliance on conventional medication. Conclusion:: The integration of yoga and spiritual practices as complementary and non-invasive adjunctive therapies represents a promising approach to addressing the spectrum of neurological disorders plaguing modern society.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136358100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract:: Herbal medicine has gained massive popularity among researchers worldwide. The leading causes of this rapid development are lower side effects, lower prices, and higher availability of plant extracts compared to synthetic drugs. Ginger (Zingiber officinale), from the Zingiberaceae family, is one of the most commonly used and popular plants utilized as a dietary spice, herbal medicine, and food preservative. Its biologically active components, such as shogaol, paradol, zingerone, and especially gingerol, can be highly effective for the treatment of several illnesses through various anti-inflammatory, anti-neoplastic, anti-emetic, anti-oxidant, antihyperlipidemic and anti-hyperglycaemic activities. Ginger can also be used as an antiviral agent. Numerous studies have been conducted to investigate the antiviral efficacy of ginger on several viruses; for instance, severe acute respiratory syndrome 2 (SARS-COV-2), influenza, dengue, hepatitis, herpes, Human Papilloma Virus (HPV), Human Immunodeficiency Virus (HIV), Epstein- Barr Virus (EBV), Chikungunya virus and so on. This review summarizes the efficacy of ginger in preventing or treating several viral diseases and its mechanism of action, emphasizing coronavirus disease 2019 (COVID-19) due to the current high burden of disease worldwide.
{"title":"The Antiviral Potential of Zingiber officinale (Ginger): A Comprehensive Literature Review","authors":"Mohammad Amin Amini fard, Mahsa Asadi Anar, Gisou Erabi, Farhad Nikzad, Mehran Ghasemi, Mahdi Seyfi-Ghale-Jogh, Fateme Javaherchian, ladan baghban, Amir Jafari, Sepehr Olangian-Tehrani, Sepehr Nanbakhsh, Niloofar Deravi, Zohreh Tutunchian, Tina Mansourian, Fariba Arbab Mojeni, Alaleh Alizadeh, Farzad Sheikhzadeh, Parisa alsadat Dadkhah, Fatemeh Chichagi","doi":"10.2174/0122150838250624230926043708","DOIUrl":"https://doi.org/10.2174/0122150838250624230926043708","url":null,"abstract":"Abstract:: Herbal medicine has gained massive popularity among researchers worldwide. The leading causes of this rapid development are lower side effects, lower prices, and higher availability of plant extracts compared to synthetic drugs. Ginger (Zingiber officinale), from the Zingiberaceae family, is one of the most commonly used and popular plants utilized as a dietary spice, herbal medicine, and food preservative. Its biologically active components, such as shogaol, paradol, zingerone, and especially gingerol, can be highly effective for the treatment of several illnesses through various anti-inflammatory, anti-neoplastic, anti-emetic, anti-oxidant, antihyperlipidemic and anti-hyperglycaemic activities. Ginger can also be used as an antiviral agent. Numerous studies have been conducted to investigate the antiviral efficacy of ginger on several viruses; for instance, severe acute respiratory syndrome 2 (SARS-COV-2), influenza, dengue, hepatitis, herpes, Human Papilloma Virus (HPV), Human Immunodeficiency Virus (HIV), Epstein- Barr Virus (EBV), Chikungunya virus and so on. This review summarizes the efficacy of ginger in preventing or treating several viral diseases and its mechanism of action, emphasizing coronavirus disease 2019 (COVID-19) due to the current high burden of disease worldwide.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134945072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract: Ethnopharmacological relevance: Mesua ferrea Linn. belonging to family Guttiferae. The plant widely grows in the hills and is planted in gardens in many parts of India. It is cultivated as an ornamental plant because of its graceful shape, pink to red hanging leaves and enormous wonderful, fragrant white blossoms. The current review summarizes different significant, fundamental and medicinal properties of this Indian therapeutic herb. It is known to be an evergreen tree 20-30 m in height. Along with its elaborate utilization, entire plant has different therapeutic values in the conventional system of drugs. The main aim of this review is to provide a brief overview of the pharmacological, phytochemical, pharmacognostic, ethanomedical and toxicological studies of M. ferrea. A comprehensive review of the literature was conducted using multiple search sites such as PubMed, Google Scholar, Springer, and Science Direct, Scopus, Web of Science, SciFinder, etc. Other literary sources include Wikipedia, ethnobotanical books, and botanical journals. Numerous phytochemicals have been discovered and isolated from Mesua ferrea plant parts which include xanthones, terpenoids, sterol, β-amyrin, β-sitosterol, mesuaferrol, mesuaferrin-A, mesuaferrin B, caloxanthone C,1,8-dihydro-3-methoxy-6- methylanthraquinone, friedelin, fats, flavanoids and betulinic acid. All of the documented pharmacological activities, such as antioxidant and antibacterial activity, antiarthritic, antiinflammatory, antivenom, antiulcerogenic, anticonvulsant, wound healing, depressant, analgesic are due to the presence of certain phytochemical substances. This review mainly targets the botanical aspects of Mesua ferrea along with their phytochemical constituents, ethnomedicinal use, different pharmacological activity, and future possibilities. Mesua ferrea is very important in the traditional Indian system. More research is needed to uncover important features of Mesua ferrea in medical practice.
摘要:民族药理学相关性:铁蒺藜;属于木虱科。这种植物广泛生长在山上，在印度许多地方的花园里也有种植。它是一种观赏植物，因为它的形状优美，粉红色到红色的垂叶和巨大的美丽，芳香的白色花朵。目前的综述总结了不同的重要意义，基本和药用性质的印度治疗草药。众所周知，它是一种常青树，高度为20-30米。随着其被广泛利用，整个植物在常规药物体系中具有不同的治疗价值。本文综述了铁芽孢杆菌的药理、植物化学、生药学、乙醇医学和毒理学等方面的研究进展。使用PubMed、Google Scholar、Springer、Science Direct、Scopus、Web of Science、SciFinder等多个搜索网站对文献进行了全面的综述。其他文献来源包括维基百科、民族植物学书籍和植物学期刊。从铁杉属植物中已发现和分离出大量的植物化学物质，包括山酮类、萜类、甾醇、β-amyrin、β-谷甾醇、甲铁酚、甲铁蛋白a、甲铁蛋白B、卡氧蒽酮C、1,8-二氢-3-甲氧基-6-甲基蒽醌、叶黄素、脂肪、类黄酮和白桦酸。所有记录的药理学活性，如抗氧化和抗菌活性，抗关节炎，抗炎，抗蛇毒，抗溃疡，抗惊厥，伤口愈合，抑郁，镇痛都是由于某些植物化学物质的存在。本文主要从植物化学成分、民族医药用途、药理活性及其发展前景等方面对铁杉属植物进行了综述。铁杉在传统的印度体系中非常重要。需要更多的研究来揭示铁质蕨在医学实践中的重要特征。
{"title":"A Review of Ethnopharmacological Uses, Phytochemistry and Pharmacological Attributes of Mesua ferrea Linn.","authors":"Sayukta Vijay Pahurkar, Ajaykumar Rikhabchand Surana, Pratiksha Ramesh Pawar","doi":"10.2174/0122150838249162230922034813","DOIUrl":"https://doi.org/10.2174/0122150838249162230922034813","url":null,"abstract":"Abstract: Ethnopharmacological relevance: Mesua ferrea Linn. belonging to family Guttiferae. The plant widely grows in the hills and is planted in gardens in many parts of India. It is cultivated as an ornamental plant because of its graceful shape, pink to red hanging leaves and enormous wonderful, fragrant white blossoms. The current review summarizes different significant, fundamental and medicinal properties of this Indian therapeutic herb. It is known to be an evergreen tree 20-30 m in height. Along with its elaborate utilization, entire plant has different therapeutic values in the conventional system of drugs. The main aim of this review is to provide a brief overview of the pharmacological, phytochemical, pharmacognostic, ethanomedical and toxicological studies of M. ferrea. A comprehensive review of the literature was conducted using multiple search sites such as PubMed, Google Scholar, Springer, and Science Direct, Scopus, Web of Science, SciFinder, etc. Other literary sources include Wikipedia, ethnobotanical books, and botanical journals. Numerous phytochemicals have been discovered and isolated from Mesua ferrea plant parts which include xanthones, terpenoids, sterol, β-amyrin, β-sitosterol, mesuaferrol, mesuaferrin-A, mesuaferrin B, caloxanthone C,1,8-dihydro-3-methoxy-6- methylanthraquinone, friedelin, fats, flavanoids and betulinic acid. All of the documented pharmacological activities, such as antioxidant and antibacterial activity, antiarthritic, antiinflammatory, antivenom, antiulcerogenic, anticonvulsant, wound healing, depressant, analgesic are due to the presence of certain phytochemical substances. This review mainly targets the botanical aspects of Mesua ferrea along with their phytochemical constituents, ethnomedicinal use, different pharmacological activity, and future possibilities. Mesua ferrea is very important in the traditional Indian system. More research is needed to uncover important features of Mesua ferrea in medical practice.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Several drugs have been proposed for the treatment of breast cancer, but none has fully treated the disease so far. Methods: MCF7 cells were cultured in RPMI-1640 medium, consisting of different concentrations of aqueous-alcoholic extract of the fruit of Capparis spinosa (0.125, 0.25, 0.5, 1, 1.5, 2, 2.5, and 5 mg/mL) for 48 and 72 hours. MTT assay was used to determine the cell proliferation inhibition (IC50). The percentage of apoptotic cells was determined by flow cytometry analysis using Annexin V/PI apoptosis detection kit. RT-PCR method was carried out to assess the fold changes of OCT4, NANOG, and SOX2 genes. Two-way ANOVA (tukeys) and t-test (repeated measure) were used for the statistical analysis of obtained data MTT assay and RT-PCR method, respectively. p < 0.05 was considered significant. Results: Our results have shown that cell death was induced by increasing fruit of Capparis spinosa extract concentration. IC50 was observed at 48 h culture period with 4.81 mg/mL, and 72 h with 2.72 mg/mL fruit extract, respectively. Flow cytometry results exhibited an obviously significant augmentation in apoptotic MF7 cells. According to RT-PCR findings on the fruit of Capparis spinosa extract-treated cells, the mean expression of OCT4, NANOG, and SOX2 genes decreased after 48 and 72 h of incubation with IC50 concentration compared to controls. Conclusion: The fruit of the Capparis spinosa species was able to decrease the expression of self-renewal genes in the MCF7 cell line. Therefore, the fruit of Capparis spinosa extract can be considered a promising candidate for the management of human breast cancer after clinical trials.
{"title":"The Survey of the Fruit of Capparis spinosa Extracts Effects on the Expressional Profile of Essential Self-renewal Genes in MCF7 Cell Line","authors":"Faezeh Askarian Marji, Ameneh Javid, Mojgan Noroozi Karimabad, Seyedeh Atekeh Torabizadeh, Mohammad Reza Mirzaei","doi":"10.2174/0122150838258062230920091457","DOIUrl":"https://doi.org/10.2174/0122150838258062230920091457","url":null,"abstract":"Background: Several drugs have been proposed for the treatment of breast cancer, but none has fully treated the disease so far. Methods: MCF7 cells were cultured in RPMI-1640 medium, consisting of different concentrations of aqueous-alcoholic extract of the fruit of Capparis spinosa (0.125, 0.25, 0.5, 1, 1.5, 2, 2.5, and 5 mg/mL) for 48 and 72 hours. MTT assay was used to determine the cell proliferation inhibition (IC50). The percentage of apoptotic cells was determined by flow cytometry analysis using Annexin V/PI apoptosis detection kit. RT-PCR method was carried out to assess the fold changes of OCT4, NANOG, and SOX2 genes. Two-way ANOVA (tukeys) and t-test (repeated measure) were used for the statistical analysis of obtained data MTT assay and RT-PCR method, respectively. p < 0.05 was considered significant. Results: Our results have shown that cell death was induced by increasing fruit of Capparis spinosa extract concentration. IC50 was observed at 48 h culture period with 4.81 mg/mL, and 72 h with 2.72 mg/mL fruit extract, respectively. Flow cytometry results exhibited an obviously significant augmentation in apoptotic MF7 cells. According to RT-PCR findings on the fruit of Capparis spinosa extract-treated cells, the mean expression of OCT4, NANOG, and SOX2 genes decreased after 48 and 72 h of incubation with IC50 concentration compared to controls. Conclusion: The fruit of the Capparis spinosa species was able to decrease the expression of self-renewal genes in the MCF7 cell line. Therefore, the fruit of Capparis spinosa extract can be considered a promising candidate for the management of human breast cancer after clinical trials.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract:: Ganoderma lucidum is a traditional Asian medication used in China, Korea, and Japan. It is a well-known medicinal fungus that is regarded as the elixir of life. Polysaccharides, proteins, enzymes, sterols, fatty acids, vitamins, minerals, and peptides are some of the 400 physiologically active substances. Anti-inflammatory, anti-ulcer, anti-diabetic, antiandrogenic, anti-aging, anti-fibrotic, antioxidant, hepatoprotective, sleep-promoting, anticarcinogenic, chemo and radioprotective, immunomodulation, estrogenic, and antibacterial properties are just a few of the numerous reported pharmacological effects. This review will help us to examine the role that this macro fungus holds in various therapeutic applications and how it can be a significant influence in the field of medicine.
{"title":"Ganoderma lucidum, a Potential Revolutionary Macro Fungus in the Field of Medicine","authors":"Isha Rani, Mehak Gupta, Samarth Sharma, Dr. Gagandeep Kaur, Pankaj Sharma","doi":"10.2174/0122150838264220230926002018","DOIUrl":"https://doi.org/10.2174/0122150838264220230926002018","url":null,"abstract":"Abstract:: Ganoderma lucidum is a traditional Asian medication used in China, Korea, and Japan. It is a well-known medicinal fungus that is regarded as the elixir of life. Polysaccharides, proteins, enzymes, sterols, fatty acids, vitamins, minerals, and peptides are some of the 400 physiologically active substances. Anti-inflammatory, anti-ulcer, anti-diabetic, antiandrogenic, anti-aging, anti-fibrotic, antioxidant, hepatoprotective, sleep-promoting, anticarcinogenic, chemo and radioprotective, immunomodulation, estrogenic, and antibacterial properties are just a few of the numerous reported pharmacological effects. This review will help us to examine the role that this macro fungus holds in various therapeutic applications and how it can be a significant influence in the field of medicine.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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