F. Pigliacelli, E. Abril, N. Cameli, Paolo Iacovelli, Maria Mariano
Atopic dermatitis (AD) is a chronic inflammatory skin disease clinically characterized by eczematous skin manifestations; sometimes it can manifest with non-specific clinical features, in common with other skin conditions, such as infectious and neoplastic diseases. We would like to underline the importance of accurate dermatologic examination and rigorous anamnesis in patient affected by AD, in order to avoid misdiagnosis and delayed treatments.
特应性皮炎（AD）是一种慢性炎症性皮肤病，临床上以皮肤湿疹为特征；有时也会表现出非特异性的临床特征，与其他皮肤病（如感染性和肿瘤性疾病）相同。我们希望强调对 AD 患者进行准确的皮肤科检查和严格的病史询问的重要性，以避免误诊和延误治疗。
{"title":"Scabies mimicking relapsing atopic dermatitis","authors":"F. Pigliacelli, E. Abril, N. Cameli, Paolo Iacovelli, Maria Mariano","doi":"10.4081/dr.2024.10070","DOIUrl":"https://doi.org/10.4081/dr.2024.10070","url":null,"abstract":"Atopic dermatitis (AD) is a chronic inflammatory skin disease clinically characterized by eczematous skin manifestations; sometimes it can manifest with non-specific clinical features, in common with other skin conditions, such as infectious and neoplastic diseases. We would like to underline the importance of accurate dermatologic examination and rigorous anamnesis in patient affected by AD, in order to avoid misdiagnosis and delayed treatments.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vulvar lichen sclerosus is a chronic inflammatory condition characterized by the thinning and atrophy of the skin and mucosa surrounding the vulva and anus. This study evaluates the efficacy of a treatment protocol utilizing blue-diode laser photobiomodulation in managing vulval lichen sclerosus symptoms in a cohort of 12 female patients. The treatment protocol consisted of laser sessions for 3 times a week for 2 weeks, and follow-up sessions over a 16-week period. Objective and subjective parameters were assessed before treatment, at the end of treatment, and at 4-month follow-up visits. Results demonstrated significant reductions in subjective symptoms such as itching and pain, as well as improvements in objective signs including erythema and fissures. No side effects were observed, indicating the safety and tolerability of laser treatment. These findings suggest that photobiomodulation can be an effective therapeutic option for patients with vulval lichen sclerosus, with future research aimed at refining treatment protocols and evaluating its long-term benefits.
{"title":"Blue diode laser as supportive therapy for the management of vulvar lichen sclerosus","authors":"Serena Bergamo, M. Gobbo, Silvia Chimenton, Giorgia D'Angelo, Luca Guarda Nardini, Alessandro Gatti","doi":"10.4081/dr.2024.10046","DOIUrl":"https://doi.org/10.4081/dr.2024.10046","url":null,"abstract":"Vulvar lichen sclerosus is a chronic inflammatory condition characterized by the thinning and atrophy of the skin and mucosa surrounding the vulva and anus. This study evaluates the efficacy of a treatment protocol utilizing blue-diode laser photobiomodulation in managing vulval lichen sclerosus symptoms in a cohort of 12 female patients. The treatment protocol consisted of laser sessions for 3 times a week for 2 weeks, and follow-up sessions over a 16-week period. Objective and subjective parameters were assessed before treatment, at the end of treatment, and at 4-month follow-up visits. Results demonstrated significant reductions in subjective symptoms such as itching and pain, as well as improvements in objective signs including erythema and fissures. No side effects were observed, indicating the safety and tolerability of laser treatment. These findings suggest that photobiomodulation can be an effective therapeutic option for patients with vulval lichen sclerosus, with future research aimed at refining treatment protocols and evaluating its long-term benefits.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141923606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psoriasis is an inflammatory chronic disease of the skin typically located on the extensor surfaces of the body, and the trunk. Patients with psoriasis can often present multiple characteristics, such as lesions located in difficult-to-treat (DTT) areas or a high severity of the disease, which can negatively affect their quality of life. There is a lack of consensus in identifying the best therapy for these complex patient populations, especially after the failure of one or multiple lines of therapy. In this regard, we report a case series describing patients with psoriasis located in different DTT areas or presenting a high Psoriasis Area and Severity Index score at baseline and treated ineffectively with prior lines of therapy. Finally, patients achieved complete remission following therapy with tildrakizumab 200 mg (anti-IL-23p19), highlighting its potential efficacy in these patient populations.
{"title":"Efficacy of tildrakizumab 200 mg for treating difficult-to-treat patient populations with moderate to severe plaque psoriasis","authors":"P. Dapavo, M. Megna, M. Talamonti","doi":"10.4081/dr.2024.9999","DOIUrl":"https://doi.org/10.4081/dr.2024.9999","url":null,"abstract":"Psoriasis is an inflammatory chronic disease of the skin typically located on the extensor surfaces of the body, and the trunk. Patients with psoriasis can often present multiple characteristics, such as lesions located in difficult-to-treat (DTT) areas or a high severity of the disease, which can negatively affect their quality of life. There is a lack of consensus in identifying the best therapy for these complex patient populations, especially after the failure of one or multiple lines of therapy. In this regard, we report a case series describing patients with psoriasis located in different DTT areas or presenting a high Psoriasis Area and Severity Index score at baseline and treated ineffectively with prior lines of therapy. Finally, patients achieved complete remission following therapy with tildrakizumab 200 mg (anti-IL-23p19), highlighting its potential efficacy in these patient populations.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
After Mohs Micrographic Surgery dermsurgeons utilise local flaps, full or partial thickness grafts, with good or acceptable cosmetic results. When we are dealing with older and problematic patients, blood thinner users, and non-collaborative people with large facial neoplasms, using flaps may be very difficult and grafts become the best choice. Our aim was to assess a technique to graft very easily, quickly and safely, full thickness skin grafts in facial wounds and have good cosmetic results in those older and problematic people. Ten elderly patients who underwent Mohs Surgery or other surgical procedures have been grafted with this technique that we called “Mosaic graft”, made possible using a dermal glue in a new way. In some cases, for bigger defects, we also assessed the “Stripes” variant of this technique. Graft survival was almost always complete in all cases and after 6 months the cosmetic outcomes were good. This “Mosaic graft” technique and its “Stripes” variant showed good reliability, fast execution, easy harvesting with tissue saving, good cosmetic outcomes, making this technique a very good choice for older and problematic patients.
{"title":"“Mosaic graft” technique and surgical dermal glue in Mohs micrographic surgery and general dermatologic surgery","authors":"G. Vezzoni, Cristina Ricci","doi":"10.4081/dr.2024.9966","DOIUrl":"https://doi.org/10.4081/dr.2024.9966","url":null,"abstract":"After Mohs Micrographic Surgery dermsurgeons utilise local flaps, full or partial thickness grafts, with good or acceptable cosmetic results. When we are dealing with older and problematic patients, blood thinner users, and non-collaborative people with large facial neoplasms, using flaps may be very difficult and grafts become the best choice. Our aim was to assess a technique to graft very easily, quickly and safely, full thickness skin grafts in facial wounds and have good cosmetic results in those older and problematic people. Ten elderly patients who underwent Mohs Surgery or other surgical procedures have been grafted with this technique that we called “Mosaic graft”, made possible using a dermal glue in a new way. In some cases, for bigger defects, we also assessed the “Stripes” variant of this technique. Graft survival was almost always complete in all cases and after 6 months the cosmetic outcomes were good. This “Mosaic graft” technique and its “Stripes” variant showed good reliability, fast execution, easy harvesting with tissue saving, good cosmetic outcomes, making this technique a very good choice for older and problematic patients.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefano Veraldi, I. F. Aromolo, Francesca Germiniasi, G. Nazzaro
Pityriasis versicolor is characterized clinically by slightly scaly, hyper- or hypopigmented macules usually located on the chest, shoulders, back and arms. Rare cases of atypical locations of pityriasis versicolor have been described, such as groins, penis and perineum. We present three cases of pityriasis versicolor located exclusively on the submammary folds, pubis and inguinal folds (the latter in an 11-year-old girl), respectively. In consideration of both location and clinical presentation of pityriasis versicolor in these three patients, we think that the diagnosis of “erythrasmoid” pityriasis versicolor is acceptable. Differential diagnosis with erythrasma must be taken into consideration. Mycological and bacteriological examinations are therefore necessary in order to make a correct diagnosis and specific therapy.
{"title":"Erythrasmoid pityriasis versicolor: three case reports and review of the literature","authors":"Stefano Veraldi, I. F. Aromolo, Francesca Germiniasi, G. Nazzaro","doi":"10.4081/dr.2024.9976","DOIUrl":"https://doi.org/10.4081/dr.2024.9976","url":null,"abstract":"Pityriasis versicolor is characterized clinically by slightly scaly, hyper- or hypopigmented macules usually located on the chest, shoulders, back and arms. Rare cases of atypical locations of pityriasis versicolor have been described, such as groins, penis and perineum. We present three cases of pityriasis versicolor located exclusively on the submammary folds, pubis and inguinal folds (the latter in an 11-year-old girl), respectively. In consideration of both location and clinical presentation of pityriasis versicolor in these three patients, we think that the diagnosis of “erythrasmoid” pityriasis versicolor is acceptable. Differential diagnosis with erythrasma must be taken into consideration. Mycological and bacteriological examinations are therefore necessary in order to make a correct diagnosis and specific therapy.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giulia Bazzacco, Carlotta Nardello, R. D. Caposiena Caro, N. di Meo, I. Zalaudek, Marina Agozzino
Cutaneous larva migrans (CLM) is a zoonotic disease endemic in tropical regions. CLM diagnosis mainly relies on the morphology of the skin lesions, however dermoscopy can improve diagnostic accuracy. In this paper, we report two cases of CLM to highlight the importance of dermoscopic follow-up in early identification of treatment failure, as well as the effectiveness of topical ivermectin as a combined medication.
{"title":"Cutaneous larva migrans: is dermoscopy useful for the treatment?","authors":"Giulia Bazzacco, Carlotta Nardello, R. D. Caposiena Caro, N. di Meo, I. Zalaudek, Marina Agozzino","doi":"10.4081/dr.2024.10049","DOIUrl":"https://doi.org/10.4081/dr.2024.10049","url":null,"abstract":"Cutaneous larva migrans (CLM) is a zoonotic disease endemic in tropical regions. CLM diagnosis mainly relies on the morphology of the skin lesions, however dermoscopy can improve diagnostic accuracy. In this paper, we report two cases of CLM to highlight the importance of dermoscopic follow-up in early identification of treatment failure, as well as the effectiveness of topical ivermectin as a combined medication.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141666925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benedetta Sonego, Giulia Bazzacco, E. Zelin, C. Conforti, I. Zalaudek, N. di Meo
Riehl’s melanosis (RM) is a pigmentary disorder, more common in individuals with dark skin phototypes, considered a form of pigmented contact dermatitis. In this paper we present a case of RM due to the rubber component of a work facial mask in which dermoscopy and patch test were the most important tools to help physicians in diagnosis. In addition, we reviewed the main dermoscopic clues that may be useful in differential diagnosis with others facial pigmentary disorders.
{"title":"Dermoscopy of Riehl’s melanosis: a case report and a short review of the literature","authors":"Benedetta Sonego, Giulia Bazzacco, E. Zelin, C. Conforti, I. Zalaudek, N. di Meo","doi":"10.4081/dr.2024.9983","DOIUrl":"https://doi.org/10.4081/dr.2024.9983","url":null,"abstract":"Riehl’s melanosis (RM) is a pigmentary disorder, more common in individuals with dark skin phototypes, considered a form of pigmented contact dermatitis. In this paper we present a case of RM due to the rubber component of a work facial mask in which dermoscopy and patch test were the most important tools to help physicians in diagnosis. In addition, we reviewed the main dermoscopic clues that may be useful in differential diagnosis with others facial pigmentary disorders.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An 87-year-old man presented for treatment of a histology-proven basal cell carcinoma involving the left medial canthus. The lesion was successfully resected with adequate margins under local anaesthesia and resulted in a defect measuring 2 x 1.5 cm. How would you repair this defect?
一名 87 岁的老人因左眼内侧眦部患组织学证实的基底细胞癌前来就诊。在局部麻醉的情况下，成功切除了病灶，并留有足够的切缘，造成了 2 x 1.5 厘米的缺损。您将如何修复这个缺损？
{"title":"Repair of a medial canthal defect","authors":"Alberto Murtas, Virginia Maffei, Fabrizio Fantini","doi":"10.4081/dr.2024.10001","DOIUrl":"https://doi.org/10.4081/dr.2024.10001","url":null,"abstract":"An 87-year-old man presented for treatment of a histology-proven basal cell carcinoma involving the left medial canthus. The lesion was successfully resected with adequate margins under local anaesthesia and resulted in a defect measuring 2 x 1.5 cm. How would you repair this defect?","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141683759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vitiligo is an iconic dermatological pathology as its clinical manifestations indelibly mark the patient through the appearance of white spots all over the body. The oldest written testimonies referring to vitiligo are: the first texts of Ayurveda, the Ebers Papyrus and the Leviticus of the Old Testament. During the Roman Empire, the doctors Aulus Cornelius Celsus and Galen, respectively in the I and II centuries AD, were the first to describe this skin disease and their statements were used by all subsequent authors. Hieronymus Mercurialis in the XVI century, Joseph Jakob Ritter Plenck in the XVIII century and Vincenzo Chiarugi again in the XIX century based their writings on the references of the two Roman doctors. After centuries of scientific inaction in the XIX century, there was an exponential increase in dermatological studies and the medical-scientific works produced in this period laid the foundations of modern dermatology. The nineteenth-century texts of Robert Willan and Thomas Bateman, Jean-Louis Alibert, Ferdinand von Hebra, and Moriz Kaposi proved fundamental for the study of skin pathologies, including vitiligo. The nineteenth-century medical-scientific vision and approach to vitiligo is shown in this work through the presentation of direct quotes extrapolated from the most important works of the authors mentioned above, this served to historically contextualize the gradual progress of medical study regarding this skin pathology.
白癜风是一种标志性的皮肤病，因为它的临床表现是全身出现白斑，给患者留下难以磨灭的印记。提到白癜风的最古老的书面证据有：最早的阿育吠陀经文、埃伯斯纸草和《旧约全书》中的利未记。在罗马帝国时期，公元一世纪和二世纪的医生 Aulus Cornelius Celsus 和 Galen 是第一个描述这种皮肤病的人，他们的说法被后来的所有作者所采用。XVI 世纪的 Hieronymus Mercurialis、XVIII 世纪的 Joseph Jakob Ritter Plenck 和 XIX 世纪的 Vincenzo Chiarugi 都是以这两位罗马医生的论述为基础撰写著作的。在经历了几个世纪的科学无为之后，十九世纪的皮肤病学研究急剧增加，这一时期产生的医学科学著作奠定了现代皮肤病学的基础。十九世纪罗伯特-威兰和托马斯-贝特曼、让-路易-阿利伯特、费迪南德-冯-赫布拉和莫里兹-卡波西的著作被证明是研究包括白癜风在内的皮肤病理学的基础。本著作通过直接引用上述作者最重要作品中的内容，展示了十九世纪医学科学界对白癜风的看法和研究方法，这有助于从历史的角度来梳理医学界对这一皮肤病理学研究的逐步进展。
{"title":"Vitiligo in the 19th-century dermatological works of Vincenzo Chiarugi, Robert Willan, Jean-Louis Alibert, and Ferdinand von Hebra","authors":"Flavio Stocco, Mauro Picardo, Viviana Lora","doi":"10.4081/dr.2024.10042","DOIUrl":"https://doi.org/10.4081/dr.2024.10042","url":null,"abstract":"Vitiligo is an iconic dermatological pathology as its clinical manifestations indelibly mark the patient through the appearance of white spots all over the body. The oldest written testimonies referring to vitiligo are: the first texts of Ayurveda, the Ebers Papyrus and the Leviticus of the Old Testament. During the Roman Empire, the doctors Aulus Cornelius Celsus and Galen, respectively in the I and II centuries AD, were the first to describe this skin disease and their statements were used by all subsequent authors. Hieronymus Mercurialis in the XVI century, Joseph Jakob Ritter Plenck in the XVIII century and Vincenzo Chiarugi again in the XIX century based their writings on the references of the two Roman doctors. After centuries of scientific inaction in the XIX century, there was an exponential increase in dermatological studies and the medical-scientific works produced in this period laid the foundations of modern dermatology. The nineteenth-century texts of Robert Willan and Thomas Bateman, Jean-Louis Alibert, Ferdinand von Hebra, and Moriz Kaposi proved fundamental for the study of skin pathologies, including vitiligo. The nineteenth-century medical-scientific vision and approach to vitiligo is shown in this work through the presentation of direct quotes extrapolated from the most important works of the authors mentioned above, this served to historically contextualize the gradual progress of medical study regarding this skin pathology.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Scarpato, M. Palla, S. Strippoli, L. Tagliaferri, Luca Fania, M. Saponara, A. Carbone, F. Spagnolo, Flavia Silvestri, P. Ascierto
Basal cell carcinoma (BCC) is the most common malignant tumour in white populations. Multiple studies demonstrated that the aberrant activation of Hedgehog signaling is a driver of BCC development, and its blockade represents a potential therapeutic target. In Italy, clinicians can prescribe Hedgehog inhibitors (HhIs) Vismodegib and Sonidegib. To highlight the treatment choice of clinicians, we conducted an online survey between November 1 and November 18, 2020 with 33 Italian clinicians from 27 reference hospitals, in which each participant received an anonymous survey consisting of two multiple-choice questions on clinical efficacy and safety profile of Sonidegib and Vismodegib. Respondents reported their opinions on which efficacy and tolerability data of the pivotal phase-II BOLT trial were more relevant in the treatment choice of patients with locally advanced BCC (laBCC). This survey shows that overall response rate (ORR) and the duration of response (DoR) are the most expected across dermatologists and oncologists. The different pharmacokinetic profile of the two HhIs are behind their diverse toxicity spectrum, dose and schedule modification seem to address the choice between vismodegib and sonidegib among dermato-oncology prescribers.
{"title":"Survey of the impact of BOLT-trial data on oncologists’ and dermatologists’ decision-making in treating patients with locally advanced basal cell carcinoma","authors":"L. Scarpato, M. Palla, S. Strippoli, L. Tagliaferri, Luca Fania, M. Saponara, A. Carbone, F. Spagnolo, Flavia Silvestri, P. Ascierto","doi":"10.4081/dr.2024.9882","DOIUrl":"https://doi.org/10.4081/dr.2024.9882","url":null,"abstract":"Basal cell carcinoma (BCC) is the most common malignant tumour in white populations. Multiple studies demonstrated that the aberrant activation of Hedgehog signaling is a driver of BCC development, and its blockade represents a potential therapeutic target. In Italy, clinicians can prescribe Hedgehog inhibitors (HhIs) Vismodegib and Sonidegib. To highlight the treatment choice of clinicians, we conducted an online survey between November 1 and November 18, 2020 with 33 Italian clinicians from 27 reference hospitals, in which each participant received an anonymous survey consisting of two multiple-choice questions on clinical efficacy and safety profile of Sonidegib and Vismodegib. Respondents reported their opinions on which efficacy and tolerability data of the pivotal phase-II BOLT trial were more relevant in the treatment choice of patients with locally advanced BCC (laBCC). This survey shows that overall response rate (ORR) and the duration of response (DoR) are the most expected across dermatologists and oncologists. The different pharmacokinetic profile of the two HhIs are behind their diverse toxicity spectrum, dose and schedule modification seem to address the choice between vismodegib and sonidegib among dermato-oncology prescribers.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141681961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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