Dermatology Reports最新文献

Dear Editor, Pilomatricoma, or Malherbe's calcifying epithelioma, is a benign neoplasm derived from hair follicle matrix cells. It usually presents as a solitary, firm, slow-growing subcutaneous nodule. Multiple pilomatricomas occur in about 2% of cases and may be associated with syndromes like Gardner's syndrome, Turner syndrome, and myotonic dystrophy. The bullous variant is an exceptionally rare form that presents with an overlying blister due to lymphatic dilation. [...].

Dear Editor, Bullous scabies is one of the most rare variant of scabies. Scabies is an itchy skin disease caused by Sarcoptes scabies var. hominis. Recently, it was included in the World Health Organization roadmap for neglected tropical diseases from 2021 to 2030. The prevalence of scabies is very high in poor populations causing elevated mortality rate. Data regarding prevalence reported about 200 million cases of scabies worldwide in 2015. [...].

Microinfusion of medications into the skin (MMP®) is an innovative method that employs tattoo devices to administer pharmaceuticals transdermally. This technique facilitates the formation of microchannels in the skin, allowing for localized drug deposition with minimal systemic absorption and fewer adverse effects. A literature search was conducted using PubMed and Google Scholar to identify studies discussing the application of MMP® as a transdermal drug delivery method, covering publications up to October 2025. All studies identified through the literature search were summarized in chronological order from the earliest (2013) to the most recent (2025). This arrangement was chosen to illustrate the progressive evolution of the MMP® technique and its expanding clinical applications over time. Our research found 14 studies that evaluated the effectiveness of the tattoo machine for transdermal drug administration. Eight studies focused on MMP® for alopecia treatments, demonstrating notable improvements in androgenetic alopecia, alopecia areata, and frontal fibrosing alopecia, with minimal adverse reactions reported. Six studies investigated its role in treating scars and striae, showing significant lesion improvement. One study examined its use with bleomycin in basal cell carcinoma treatment, and another assessed its impact on psoriasis vulgaris with cyclosporine A and methotrexate (MTX). MMP® represents a promising, minimally invasive transdermal delivery system with a growing body of evidence supporting its application in alopecia, oncologic dermatology, and pigmentary disorders. The ability to uniformly distribute medications at targeted skin depths, combined with its favorable safety profile, highlights its potential as a valuable alternative to conventional delivery methods. Furthermore, the microneedling effect of the tattoo device itself may confer therapeutic benefits independent of pharmaceutical administration.

We report a unique case of a 1-year-old boy presenting with nonpruritic erythematous patches and mild keratotic plaques, partially following the lines of Blaschko and mainly involving the extremities. Next-generation sequencing (NGS) revealed a heterozygous missense mutation c.4724C>T (p.Thr1575Met) and a de novo mosaic deletion mutation c.6861_6869del (p.Leu2288_Gly2290del) in the ABCA12 (NM_173076.3) gene from the DNA of the patient's blood. Even more to the point, the lesional skin showed clinical improvement after 2 weeks of moisturizing treatment. Therefore, partial encapsulation treatment, widely used to enhance the percutaneous absorption of drugs, is suitable for mosaic ichthyosis given its localized skin lesions.

Fahr's syndrome is a rare entity characterized by symmetrical and bilateral non-atherosclerotic intracerebral calcifications in the basal ganglia. This entity is usually asymptomatic or may present mainly with neuro-neuropsychiatric and dermatological manifestations. Secondary bilateral striopallidodentate calcinosis (BSPDC) presentations are associated with various diseases. We describe a case of psoriasis vulgaris associated with secondary BSPDC due to hypoparathyroidism. Laboratory tests revealed hypocalcemia, hyperphosphatemia, and a low parathormone serum level; in cerebral computed tomography (CT), bilateral basal ganglia calcification was observed. Correction of calcium deficiency restored the calcium-phosphate balance and led to an improvement in psoriatic lesions. Psoriasis vulgaris is a common condition that may be associated with disturbances in calcium metabolism. Dermatologists should be aware that investigating cases resistant to conventional therapies can uncover underlying systemic disorders that significantly affect patients' quality of life.

Dear Editor, Pilomatricoma is a benign tumor characterized by differentiation from hair matrix cells to hair cortical cells. It commonly occurs on the head and neck in young individuals. Although blistering is rare, when present, it is typically observed on the upper arms, shoulders, and back. The condition is more frequently seen in teenagers and young adults; however, it is rare in young children. [...].

Dear Editor, The occurrence of multiple primary neoplasms in a single patient is rare but well documented, and the incidental discovery of a previously undiagnosed thyroid carcinoma during lymph node dissection for another primary malignancy presents a unique diagnostic challenge. [...].

Psoriasiform eruptions are increasingly reported as adverse events during treatment of atopic dermatitis (AD) with interleukin (IL)-4/IL-13 inhibitors, including dupilumab. These reactions may represent a possible overlap manifestation between AD and psoriasis (PSO), which are two conditions that, according to recent literature, could lie along a clinical spectrum and share certain clinical, pathogenetic, and histological features. We describe the case of a 30-year-old male with lifelong AD who developed psoriasiform plaques on his elbows and knees during dupilumab therapy. After discontinuation of dupilumab and initiation of upadacitinib 15 mg/day, the patient achieved substantial improvement of both AD and psoriasiform eruptions at 6 months. This case highlights dupilumab-induced psoriasiform eruptions and underscores the therapeutic challenges associated with these clinical pictures. Upadacitinib appears to be a possible and effective treatment option for these presentations.

Dear Editor, Jellyfish stings are among the most common marine envenomations worldwide, particularly in coastal tourist regions. They typically cause immediate pain, erythema, and linear urticarial wheals. Although acute effects are well characterized, delayed cutaneous reactions remain under-recognized. These may occur days to weeks later and often mimic insect bites, eczema, or lichen planus. We report a case of delayed papular dermatitis ten days after a jellyfish sting and briefly review the literature. [...].

Several fruits have been identified as allergens and potential triggers for exacerbations of atopic dermatitis (AD). This study evaluated pineapple allergy and sensitization among adult patients with AD and examined the diagnostic accuracy of a locally produced pineapple allergen extract in skin prick tests (SPTs). A total of 30 adult patients with AD, with a mean age of 36.07±10.81 years, were enrolled in the study. Firstly, SPT was performed using a standard pineapple allergen extract manufactured by Astromed® (Astromed Inc., West Warwick, Rhode Island, USA). Subsequently, a second SPT was carried out with the pineapple allergen extract produced by Teaching Industry Allergen Dr. Soetomo General Academic Hospital, Universitas Airlangga (Surabaya, Indonesia). Data were analyzed for diagnostic test accuracy and agreement. The local pineapple SPT had a sensitivity of 33.33% and a specificity of 100%. The test exhibited a positive predictive value (PPV) of 100%, whereas the negative predictive value (NPV) was 93.10%. The agreement between the standard SPT and the local SPT was statistically significant, exhibiting moderate concordance (p=0.002). The Indonesian pineapple allergen extract for SPT can serve as an alternative diagnostic tool to assess pineapple allergy and sensitization in AD patients.