Y. Argobi, Norah Saad Jadaan, Waleed Obaid Alharbi, Sohaila Ahmed Asiri, Juri Ahmad Abdullah Alhatlani, Nujood Hassan Obaid, Seham Marei Ali Alqahtani
The importance of eyebrows in facial aesthetics has long been recognized, and eyebrows restoration is carried out by carefully depositing pigments into the epidermis. This cosmetic procedure is known as microblading which is very popular because of the progress in social media platforms. This study was designed to determine the awareness of eyebrow microblading, complication and laser removal in general population of Saudi Arabia. This was a cross-sectional study conducted in four different regions in Saudi Arabia (Asir, Qasim, Jawf, and Eastern province), from June 2023 to December 2023. Only females were included, and an online questionnaire was distributed. A convenient non-probability sampling method was adopted to gather data from participants. Data analysis was performed using SPSS version 21. A total of 705 participants were included in the study, with the majority 281 (39.9%) falling into the age group >35 years, and the mean age was 29.1±11.9 years. The study revealed a moderate level of awareness (65%) among participants regarding eyebrow microblading. However, alarming gaps regarding hygiene practices in microblading setups still exist. Notably, facing complications during the surgery was identified as a statistically significant factor associated with a higher level of awareness (p=0.049). Of the participants, 17.4% had undergone eyebrow microblading, with friends being the source of advice for 39.5% of them. Laser removal was chosen by more than 60% of microblading recipients, with varying degrees of pleasure and satisfaction reported. Eyebrow microblading is a successful cosmetic procedure with aesthetic advantages. However, this study also emphasizes the necessity for extensive public education regarding microblading, including its associated risks, restrictions, and appropriate practices. To ensure safe and ethical practices, stringent laws and licensing for certified professionals are also deemed essential.
{"title":"A comprehensive evaluation of safety and awareness in eyebrow microblading: a cross-sectional study","authors":"Y. Argobi, Norah Saad Jadaan, Waleed Obaid Alharbi, Sohaila Ahmed Asiri, Juri Ahmad Abdullah Alhatlani, Nujood Hassan Obaid, Seham Marei Ali Alqahtani","doi":"10.4081/dr.2024.9992","DOIUrl":"https://doi.org/10.4081/dr.2024.9992","url":null,"abstract":"The importance of eyebrows in facial aesthetics has long been recognized, and eyebrows restoration is carried out by carefully depositing pigments into the epidermis. This cosmetic procedure is known as microblading which is very popular because of the progress in social media platforms. This study was designed to determine the awareness of eyebrow microblading, complication and laser removal in general population of Saudi Arabia. This was a cross-sectional study conducted in four different regions in Saudi Arabia (Asir, Qasim, Jawf, and Eastern province), from June 2023 to December 2023. Only females were included, and an online questionnaire was distributed. A convenient non-probability sampling method was adopted to gather data from participants. Data analysis was performed using SPSS version 21. A total of 705 participants were included in the study, with the majority 281 (39.9%) falling into the age group >35 years, and the mean age was 29.1±11.9 years. The study revealed a moderate level of awareness (65%) among participants regarding eyebrow microblading. However, alarming gaps regarding hygiene practices in microblading setups still exist. Notably, facing complications during the surgery was identified as a statistically significant factor associated with a higher level of awareness (p=0.049). Of the participants, 17.4% had undergone eyebrow microblading, with friends being the source of advice for 39.5% of them. Laser removal was chosen by more than 60% of microblading recipients, with varying degrees of pleasure and satisfaction reported. Eyebrow microblading is a successful cosmetic procedure with aesthetic advantages. However, this study also emphasizes the necessity for extensive public education regarding microblading, including its associated risks, restrictions, and appropriate practices. To ensure safe and ethical practices, stringent laws and licensing for certified professionals are also deemed essential.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140668010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Trave, I. Salvi, C. Micalizzi, R. Castelli, Aurora Parodi, E. Cozzani
Imiquimod 5% cream is an approved treatment for actinic keratoses, superficial basal cell carcinomas and anogenital warts. Severe systemic side effects associated to imiquimod 5% cream are rare, although few cases of erythema multiforme and Stevens-Johnson syndrome have been described. We present a case of Stevens-Johnson syndrome associated to topical treatment with imiquimod of two superficial basal cell carcinomas.
{"title":"Stevens-Johnson induced by imiquimod 5% cream: a case report","authors":"I. Trave, I. Salvi, C. Micalizzi, R. Castelli, Aurora Parodi, E. Cozzani","doi":"10.4081/dr.2024.9930","DOIUrl":"https://doi.org/10.4081/dr.2024.9930","url":null,"abstract":"Imiquimod 5% cream is an approved treatment for actinic keratoses, superficial basal cell carcinomas and anogenital warts. Severe systemic side effects associated to imiquimod 5% cream are rare, although few cases of erythema multiforme and Stevens-Johnson syndrome have been described. We present a case of Stevens-Johnson syndrome associated to topical treatment with imiquimod of two superficial basal cell carcinomas.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140685327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alvise Montanari, F. Caroppo, Antonio Amabile, Anna Fortina Belloni, Franco Bassetto
Keratitis-ichthyosis-deafness syndrome (KID) is a rare genetic disorder characterized by the triad of hyperkeratosis, ichthyosis, and congenital prelingual sensorineural deafness, with less than 100 cases described in the literature. In addition to many other extra-cutaneous manifestations, these patients are burdened by two principal increased risk factors involving the skin: the risk of developing infections and the risk of developing malignant skin tumors, especially Squamous Cell Carcinoma and Trichilemmal tumors. We present the case of a 7-year-old girl with a unique genetic variant described to date, who developed 4 dyskeratotic neoformation. Since the dermatoscopic examination was not sufficient to exclude malignancy, excisional and punch biopsies were used. Nonetheless, healing was challenging, with wound dehiscence and infection onset. Ad hoc wound care management resorting to negative pressure therapy and advanced medical honey-based dressings was necessary to achieve complete wound healing.
{"title":"Suspect dyskeratotic neoformations in a 7-year-old child with keratitis-ichthyosis-deafness syndrome: diagnostic, surgical and wound care management","authors":"Alvise Montanari, F. Caroppo, Antonio Amabile, Anna Fortina Belloni, Franco Bassetto","doi":"10.4081/dr.2024.9953","DOIUrl":"https://doi.org/10.4081/dr.2024.9953","url":null,"abstract":"Keratitis-ichthyosis-deafness syndrome (KID) is a rare genetic disorder characterized by the triad of hyperkeratosis, ichthyosis, and congenital prelingual sensorineural deafness, with less than 100 cases described in the literature. In addition to many other extra-cutaneous manifestations, these patients are burdened by two principal increased risk factors involving the skin: the risk of developing infections and the risk of developing malignant skin tumors, especially Squamous Cell Carcinoma and Trichilemmal tumors. We present the case of a 7-year-old girl with a unique genetic variant described to date, who developed 4 dyskeratotic neoformation. Since the dermatoscopic examination was not sufficient to exclude malignancy, excisional and punch biopsies were used. Nonetheless, healing was challenging, with wound dehiscence and infection onset. Ad hoc wound care management resorting to negative pressure therapy and advanced medical honey-based dressings was necessary to achieve complete wound healing.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dear Editor, Subepidermal calcified nodules (SCN), are typically asymptomatic, solitary, and idiopathic cutaneous calcinosis. We report a case with two SCN with a symmetrical distribution, where a single nodule was located on the medial aspect of each of the bilateral upper eyelids in a teenage male. [...]
{"title":"A case of symmetrical subepidermal calcified nodules on the eyelids","authors":"Yoko Shimada, Hiroto Ono, Akira Shimizu","doi":"10.4081/dr.2024.9944","DOIUrl":"https://doi.org/10.4081/dr.2024.9944","url":null,"abstract":"Dear Editor, Subepidermal calcified nodules (SCN), are typically asymptomatic, solitary, and idiopathic cutaneous calcinosis. We report a case with two SCN with a symmetrical distribution, where a single nodule was located on the medial aspect of each of the bilateral upper eyelids in a teenage male. [...]","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140698883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psoriasis, affecting 2% of the population, burdens individuals physically and emotionally, with adherence challenges (39–73%). Treatment ranges from topical to systemic therapy including biologics. Although biologic therapy improves clinical outcomes, side effects lead 50% of severe cases to prefer topical treatment. This study evaluates patient satisfaction in Saudi Arabia with various psoriasis treatments, offering insights and addressing the crucial aspect of satisfaction in management. This is a cross-sectional study, using an electronic questionnaire aligned with prior research, included Saudi adults with psoriasis undergoing topical, biological, or phototherapy treatment. Exclusions encompassed non-treatment recipients and participants outside Saudi Arabia. A total of 314 psoriasis patients receiving treatment were included, the most reported types were Plaque psoriasis. The most reported sites of psoriasis included scalp. 70.1% of the patients received topical treatment, 36.3% received systematic treatment, and 18.2% used phototherapy. The participants showed an intermediate satisfaction level, the highest satisfaction for systematic treatments followed by phototherapy and the lowest satisfaction for topical treatments. Male gender, plaque psoriasis, and lack of disease follow-up were associated with poor satisfaction levels.
{"title":"Treatment satisfaction among patients with psoriasis in Saudi Arabia","authors":"Mahdi Aldhafiri, Rahaf Almutairi, Reem Albejais, Asma Almubark, Hussain Alwesaibie, Mohammed Albesher, Manayer Almustihi","doi":"10.4081/dr.2024.9967","DOIUrl":"https://doi.org/10.4081/dr.2024.9967","url":null,"abstract":"Psoriasis, affecting 2% of the population, burdens individuals physically and emotionally, with adherence challenges (39–73%). Treatment ranges from topical to systemic therapy including biologics. Although biologic therapy improves clinical outcomes, side effects lead 50% of severe cases to prefer topical treatment. This study evaluates patient satisfaction in Saudi Arabia with various psoriasis treatments, offering insights and addressing the crucial aspect of satisfaction in management. This is a cross-sectional study, using an electronic questionnaire aligned with prior research, included Saudi adults with psoriasis undergoing topical, biological, or phototherapy treatment. Exclusions encompassed non-treatment recipients and participants outside Saudi Arabia. A total of 314 psoriasis patients receiving treatment were included, the most reported types were Plaque psoriasis. The most reported sites of psoriasis included scalp. 70.1% of the patients received topical treatment, 36.3% received systematic treatment, and 18.2% used phototherapy. The participants showed an intermediate satisfaction level, the highest satisfaction for systematic treatments followed by phototherapy and the lowest satisfaction for topical treatments. Male gender, plaque psoriasis, and lack of disease follow-up were associated with poor satisfaction levels.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aims to evaluate the association between tumor necrosis factor-α (TNF–α) single nucleotide polymorphisms and psoriasis vulgaris. This cross-sectional study involved 140 Vietnamese patients of Kinh ethnicity diagnosed with psoriasis vulgaris. The diagnosis of psoriasis vulgaris was based on clinical signs and symptoms. We used Sanger sequencing to analyze two SNPs rs1799964 and rs1799724. Data were analyzed by SPSS 25. SNP rs1799964 has the highest rate of TT genotype at 62.1%, more than double the heterozygous TC genotype at 30%, CC genotype has the lowest rate at 7.9%. CC genotype of SNP rs1799724 accounted for 90% and no homozygous genotype TT was detected. No statistically significant association was found between both SNPs and clinical features (p >0.05). The Psoriasis Area and Severity Index (PASI) was significantly lower in patients with variant alleles (P =0.021). Our data show a significant negative association between SNPs variant alleles and disease’s severity. Studies with larger sample sizes and more biochemical indices may help identify reliably predictive markers for these SNPs.
{"title":"A study on tumor necrosis factor-α single nucleotide polymorphisms and psoriasis vulgaris in Vietnam","authors":"Vinh Ngo Minh, Thiên Phúc Lý, Hao Nguyen Trong, Chuong Nguyen Hoang","doi":"10.4081/dr.2024.9899","DOIUrl":"https://doi.org/10.4081/dr.2024.9899","url":null,"abstract":"This study aims to evaluate the association between tumor necrosis factor-α (TNF–α) single nucleotide polymorphisms and psoriasis vulgaris. This cross-sectional study involved 140 Vietnamese patients of Kinh ethnicity diagnosed with psoriasis vulgaris. The diagnosis of psoriasis vulgaris was based on clinical signs and symptoms. We used Sanger sequencing to analyze two SNPs rs1799964 and rs1799724. Data were analyzed by SPSS 25. SNP rs1799964 has the highest rate of TT genotype at 62.1%, more than double the heterozygous TC genotype at 30%, CC genotype has the lowest rate at 7.9%. CC genotype of SNP rs1799724 accounted for 90% and no homozygous genotype TT was detected. No statistically significant association was found between both SNPs and clinical features (p >0.05). The Psoriasis Area and Severity Index (PASI) was significantly lower in patients with variant alleles (P =0.021). Our data show a significant negative association between SNPs variant alleles and disease’s severity. Studies with larger sample sizes and more biochemical indices may help identify reliably predictive markers for these SNPs.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140711937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antonio Luca Cucchiara, Benedetta Sonego, S. Sola, C. Massone
Clear cell acanthoma (CCA) is an uncommon benign epidermal tumor of unknown origin and etiology. It is often solitary, and the presence of multiple CCAs in the same individual is rare. Typically, it presents as a slowly growing plaque or nodule located on the legs with a peripheral scaling collarette. Diagnosis is primarily based on clinical and histopathological findings, with dermoscopy enhancing diagnostic accuracy. The differential diagnosis includes various skin tumors and inflammatory dermatoses. The preferred treatment is surgical excision, as these lesions do not regress spontaneously. We describe a case of a large CCA on the right thigh associated with multiple small nodular lesions scattered across the legs.
透明细胞棘皮瘤（CCA）是一种不常见的良性表皮肿瘤，起源和病因不明。它通常是单发的，在同一个人身上出现多个 CCA 的情况并不多见。通常，它表现为缓慢生长的斑块或结节，位于腿部，周围有脱屑的丘疹。诊断主要依据临床和组织病理学结果，皮肤镜检查可提高诊断的准确性。鉴别诊断包括各种皮肤肿瘤和炎症性皮肤病。首选的治疗方法是手术切除，因为这些病变不会自发消退。我们描述了一例右大腿大面积 CCA 病例，该病例伴有散布在腿部的多个小结节性病变。
{"title":"Giant clear cell acanthoma: a case report and a review of the literature","authors":"Antonio Luca Cucchiara, Benedetta Sonego, S. Sola, C. Massone","doi":"10.4081/dr.2024.9931","DOIUrl":"https://doi.org/10.4081/dr.2024.9931","url":null,"abstract":"Clear cell acanthoma (CCA) is an uncommon benign epidermal tumor of unknown origin and etiology. It is often solitary, and the presence of multiple CCAs in the same individual is rare. Typically, it presents as a slowly growing plaque or nodule located on the legs with a peripheral scaling collarette. Diagnosis is primarily based on clinical and histopathological findings, with dermoscopy enhancing diagnostic accuracy. The differential diagnosis includes various skin tumors and inflammatory dermatoses. The preferred treatment is surgical excision, as these lesions do not regress spontaneously. We describe a case of a large CCA on the right thigh associated with multiple small nodular lesions scattered across the legs.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rahaf R. Almutairi, Atheer G. Almutairi, A. Alhallafi, Norah A Almudawi, Mohammed Abdulaziz AlSulaiman, Asem Shadid, Ruaa Alharithy
This study aimed to investigate musculoskeletal complications secondary to isotretinoin use. A systematic review was conducted, and a total of 49 studies, including analytical studies, case reports, and case series, were included in the analysis. The studies examined musculoskeletal symptoms, diagnostic findings, and treatment approaches associated with isotretinoin use. Musculoskeletal symptoms reported in the studies included lethargy, myalgia, low back pain, arthralgia, tendinopathy, and sacroiliitis. Physical examination findings and radiological findings were used to confirm the diagnoses. Treatment approaches ranged from [non-steroidal anti-inflammatory drugs (NSAIDs)] to discontinuation of isotretinoin. Some studies have explored the impact of isotretinoin dosage, treatment duration, and vitamin levels on musculoskeletal symptoms. Isotretinoin-induced sacroiliitis and [diffuse idiopathic skeletal hyperostosis (DISH)] emerged as notable musculoskeletal complications. The findings highlight the importance of monitoring patients for potential musculoskeletal side effects and implementing appropriate interventions.
{"title":"Isotretinoin musculoskeletal side effects: a systematic review","authors":"Rahaf R. Almutairi, Atheer G. Almutairi, A. Alhallafi, Norah A Almudawi, Mohammed Abdulaziz AlSulaiman, Asem Shadid, Ruaa Alharithy","doi":"10.4081/dr.2024.9845","DOIUrl":"https://doi.org/10.4081/dr.2024.9845","url":null,"abstract":"This study aimed to investigate musculoskeletal complications secondary to isotretinoin use. A systematic review was conducted, and a total of 49 studies, including analytical studies, case reports, and case series, were included in the analysis. The studies examined musculoskeletal symptoms, diagnostic findings, and treatment approaches associated with isotretinoin use. Musculoskeletal symptoms reported in the studies included lethargy, myalgia, low back pain, arthralgia, tendinopathy, and sacroiliitis. Physical examination findings and radiological findings were used to confirm the diagnoses. Treatment approaches ranged from [non-steroidal anti-inflammatory drugs (NSAIDs)] to discontinuation of isotretinoin. Some studies have explored the impact of isotretinoin dosage, treatment duration, and vitamin levels on musculoskeletal symptoms. Isotretinoin-induced sacroiliitis and [diffuse idiopathic skeletal hyperostosis (DISH)] emerged as notable musculoskeletal complications. The findings highlight the importance of monitoring patients for potential musculoskeletal side effects and implementing appropriate interventions.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140712219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Almuntaserbellah Almudaimeegh, Hanadi AlMutairi, Fatimah AlTassan, Y. Alquraishi, K. N. Nagshabandi
Nowadays androgenetic alopecia (AGA) has become a common concern of affected subjects of both sexes. Finasteride is approved by the Food and Drug Administration for the treatment of male AGA. There is no clear evidence to support the use of dutasteride in male AGA. In female AGA, the effectiveness of dutasteride and finasteride is still under debate, and there is no clear evidence to use any of them in female AGA. A systematic review was conducted to compare between dutasteride and finasteride in treating both male and female AGA, and their efficacy, safety, side effects with effective dosage. The review was done using several databases including: PubMed, Ovid Medline, Google Scholar, and Cochrane using the following search terms/keywords: "Dutasteride" AND "Finasteride" AND "Male pattern hair loss" AND "Female pattern hair loss" AND "Efficacy", "Tolerability" AND "Side effects" AND "Comparison". To search for articles related to efficacy, tolerability, side effects, used doses of dutasteride and finasteride in the treatment of male and female AGA. The review encompassed a total of nine studies. Four randomized controlled trials, one single-arm trial, two prospective cohorts, and two retrospective cohort studies. Seven studies exclusively enrolled male participants, while only two included female participants. All groups receiving various doses of dutasteride and finasteride exhibited a significant increase in hair count compared to the placebo group. Notably, dutasteride (0.5 mg) and dutasteride (2.5 mg) were significantly more effective than finasteride (1 mg) in increasing hair counts. Furthermore, no significant difference in adverse events was observed between finasteride and dutasteride. Dutasteride is more potent than finasteride in treating AGA in both males and females. All the adverse events between finasteride and dutasteride were comparable.
如今，雄激素性脱发（AGA）已成为男女患者共同关注的问题。美国食品和药物管理局已批准非那雄胺用于治疗男性雄激素性脱发。目前还没有明确的证据支持使用度他雄胺治疗男性AGA。在女性AGA中，度他雄胺和非那雄胺的疗效仍有争议，没有明确的证据支持在女性AGA中使用这两种药物。我们进行了一项系统性综述，比较了度他雄胺和非那雄胺治疗男性和女性AGA的疗效、安全性、副作用和有效剂量。该综述使用了多个数据库，包括PubMed、Ovid Medline、Google Scholar 和 Cochrane，并使用了以下检索词/关键词："都他雄胺"、"非那雄胺"、"男性脱发"、"女性脱发"、"疗效"、"耐受性"、"副作用"、"比较"。搜索与治疗男性和女性 AGA 的度他雄胺和非那雄胺的疗效、耐受性、副作用和使用剂量相关的文章。综述共包括九项研究。其中包括四项随机对照试验、一项单臂试验、两项前瞻性队列研究和两项回顾性队列研究。其中七项研究只招募了男性参与者，只有两项研究招募了女性参与者。与安慰剂组相比，接受不同剂量度他雄胺和非那雄胺治疗的所有组别毛发数量都有显著增加。值得注意的是，在增加毛发数量方面，度他雄胺（0.5 毫克）和度他雄胺（2.5 毫克）明显比非那雄胺（1 毫克）更有效。此外，非那雄胺和度他雄胺在不良反应方面没有明显差异。在治疗男性和女性 AGA 方面，度他雄胺比非那雄胺更有效。非那雄胺和度他雄胺的所有不良反应均不相上下。
{"title":"Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic review","authors":"Almuntaserbellah Almudaimeegh, Hanadi AlMutairi, Fatimah AlTassan, Y. Alquraishi, K. N. Nagshabandi","doi":"10.4081/dr.2024.9909","DOIUrl":"https://doi.org/10.4081/dr.2024.9909","url":null,"abstract":"Nowadays androgenetic alopecia (AGA) has become a common concern of affected subjects of both sexes. Finasteride is approved by the Food and Drug Administration for the treatment of male AGA. There is no clear evidence to support the use of dutasteride in male AGA. In female AGA, the effectiveness of dutasteride and finasteride is still under debate, and there is no clear evidence to use any of them in female AGA. A systematic review was conducted to compare between dutasteride and finasteride in treating both male and female AGA, and their efficacy, safety, side effects with effective dosage. The review was done using several databases including: PubMed, Ovid Medline, Google Scholar, and Cochrane using the following search terms/keywords: \"Dutasteride\" AND \"Finasteride\" AND \"Male pattern hair loss\" AND \"Female pattern hair loss\" AND \"Efficacy\", \"Tolerability\" AND \"Side effects\" AND \"Comparison\". To search for articles related to efficacy, tolerability, side effects, used doses of dutasteride and finasteride in the treatment of male and female AGA. The review encompassed a total of nine studies. Four randomized controlled trials, one single-arm trial, two prospective cohorts, and two retrospective cohort studies. Seven studies exclusively enrolled male participants, while only two included female participants. All groups receiving various doses of dutasteride and finasteride exhibited a significant increase in hair count compared to the placebo group. Notably, dutasteride (0.5 mg) and dutasteride (2.5 mg) were significantly more effective than finasteride (1 mg) in increasing hair counts. Furthermore, no significant difference in adverse events was observed between finasteride and dutasteride. Dutasteride is more potent than finasteride in treating AGA in both males and females. All the adverse events between finasteride and dutasteride were comparable.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mycosis Fungoides (MF) stands as the predominant form of primary cutaneous T-cell lymphoma (CTCL). It manifests a diverse array of clinical, histological, and immunophenotypic variations, each bearing distinct prognostic implications. The typical immunophenotypic profile of mycosis fungoides involves CD3+/CD4+/CD45RO+ memory T cells. Notably, the CD4-/CD8- double-negative variant of MF is a rare occurrence, observed in approximately 12% of early-stage cases and more prevalent in tumor-stage instances, often correlated with atypical clinical presentations. Despite its rarity, scant information is available about double-negative Mycosis Fungoides, with only a limited number of cases documented in the existing literature. This review aims to provide enhanced clarity, comprehension, and a detailed exploration of the spectrum encompassing double-negative mycosis fungoides.
真菌病（MF）是原发性皮肤 T 细胞淋巴瘤（CTCL）的主要形式。它在临床、组织学和免疫分型上表现出多种多样的变异，每种变异都对预后有不同的影响。真菌病的典型免疫表型包括 CD3+/CD4+/CD45RO+ 记忆 T 细胞。值得注意的是，CD4-/CD8-双阴性的MF变异型非常罕见，约占早期病例的12%，在肿瘤期病例中更为常见，通常与非典型的临床表现相关。尽管罕见，但有关双阴性真菌病的信息却很少，现有文献中仅记录了有限的病例。这篇综述旨在进一步阐明、理解和详细探讨双阴性真菌病的范围。
{"title":"CD4/CD8 double-negative mycosis fungoides: a review","authors":"Khalid Nabil Nagshabandi, Abdulrahman Shadid, Asem Shadid, Nouf Almuhanna","doi":"10.4081/dr.2024.9908","DOIUrl":"https://doi.org/10.4081/dr.2024.9908","url":null,"abstract":"Mycosis Fungoides (MF) stands as the predominant form of primary cutaneous T-cell lymphoma (CTCL). It manifests a diverse array of clinical, histological, and immunophenotypic variations, each bearing distinct prognostic implications. The typical immunophenotypic profile of mycosis fungoides involves CD3+/CD4+/CD45RO+ memory T cells. Notably, the CD4-/CD8- double-negative variant of MF is a rare occurrence, observed in approximately 12% of early-stage cases and more prevalent in tumor-stage instances, often correlated with atypical clinical presentations. Despite its rarity, scant information is available about double-negative Mycosis Fungoides, with only a limited number of cases documented in the existing literature. This review aims to provide enhanced clarity, comprehension, and a detailed exploration of the spectrum encompassing double-negative mycosis fungoides.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140711311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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