Pub Date : 2025-11-05Epub Date: 2025-05-07DOI: 10.4081/dr.2025.10245
Roudin H Alhasawi, Esraa A Shaheen, Noura M Alshabanat, Reem Brashi, Walaa Abdu Ahmed, Shumukh H Alqahtani, Ethar G Alharbi, Mazin Aljabri
Pemphigus is a severe autoimmune blistering disorder that significantly affects patients' quality of life. While corticosteroids and immunosuppressive agents are commonly used, they have substantial side effects, highlighting the need for safer alternatives. Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, has shown efficacy in treating other autoimmune diseases and may offer promise for pemphigus. This systematic review evaluated the clinical outcomes, safety, and potential role of apremilast in the treatment of pemphigus by synthesizing available case reports and series. A literature search was conducted across multiple databases (PubMed, EMBASE, Cochrane, Web of Science, ScienceDirect, and Google Scholar) for case reports and series involving apremilast in pemphigus. Inclusion criteria were a confirmed pemphigus diagnosis and apremilast treatment. Five studies (four case reports and one case series) involving 7 patients were included. Apremilast led to significant clinical improvement in 4 patients, with reductions in disease activity, lesion severity, and symptom scores (Pemphigus Disease Area Index [PDAI], Autoimmune Bullous Skin Disorder Intensity Score [ABSIS], Visual Analog Scale [VAS], and Numerical Rating Score [NRS]). Increases in regulatory T cells and decreases in anti-desmoglein antibodies were observed. No serious adverse events were reported, although one study noted treatment failure, possibly due to short follow-up or concurrent infections. Apremilast appears to be a promising treatment for therapy-resistant or corticosteroid-intolerant pemphigus patients. Although the evidence is limited, it supports apremilast's efficacy and favorable safety profile. Further research with larger sample sizes and randomized controlled trials is necessary to confirm these findings.
天疱疮是一种严重的自身免疫性水疱疾病,严重影响患者的生活质量。虽然通常使用皮质类固醇和免疫抑制剂,但它们有很大的副作用,因此需要更安全的替代品。Apremilast是一种口服磷酸二酯酶4 (PDE4)抑制剂,已显示出治疗其他自身免疫性疾病的疗效,并可能为天疱疮提供希望。本系统综述通过综合现有病例报告和系列研究,评估了阿普米司特在天疱疮治疗中的临床结果、安全性和潜在作用。在多个数据库(PubMed、EMBASE、Cochrane、Web of Science、ScienceDirect和谷歌Scholar)中进行文献检索,以获取有关阿普米司特治疗天疱疮的病例报告和系列。纳入标准为确诊的天疱疮和阿普米司特治疗。纳入了涉及7例患者的5项研究(4例病例报告和1例病例系列)。阿普拉米司特显著改善了4例患者的临床,降低了疾病活动性、病变严重程度和症状评分(天疱疮疾病面积指数、自身免疫性大疱性皮肤病强度评分、视觉模拟量表和数值评分)。观察到调节性T细胞增加,抗粘粒蛋白抗体减少。没有严重的不良事件报道,尽管一项研究指出治疗失败,可能是由于随访时间短或并发感染。阿普拉米司特似乎是治疗耐药或皮质类固醇不耐受天疱疮患者的一种有希望的治疗方法。尽管证据有限,但它支持阿普雷米司特的有效性和良好的安全性。进一步的研究需要更大的样本量和随机对照试验来证实这些发现。
{"title":"The efficacy of apremilast in pemphigus: a systematic review of case reports.","authors":"Roudin H Alhasawi, Esraa A Shaheen, Noura M Alshabanat, Reem Brashi, Walaa Abdu Ahmed, Shumukh H Alqahtani, Ethar G Alharbi, Mazin Aljabri","doi":"10.4081/dr.2025.10245","DOIUrl":"10.4081/dr.2025.10245","url":null,"abstract":"<p><p>Pemphigus is a severe autoimmune blistering disorder that significantly affects patients' quality of life. While corticosteroids and immunosuppressive agents are commonly used, they have substantial side effects, highlighting the need for safer alternatives. Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, has shown efficacy in treating other autoimmune diseases and may offer promise for pemphigus. This systematic review evaluated the clinical outcomes, safety, and potential role of apremilast in the treatment of pemphigus by synthesizing available case reports and series. A literature search was conducted across multiple databases (PubMed, EMBASE, Cochrane, Web of Science, ScienceDirect, and Google Scholar) for case reports and series involving apremilast in pemphigus. Inclusion criteria were a confirmed pemphigus diagnosis and apremilast treatment. Five studies (four case reports and one case series) involving 7 patients were included. Apremilast led to significant clinical improvement in 4 patients, with reductions in disease activity, lesion severity, and symptom scores (Pemphigus Disease Area Index [PDAI], Autoimmune Bullous Skin Disorder Intensity Score [ABSIS], Visual Analog Scale [VAS], and Numerical Rating Score [NRS]). Increases in regulatory T cells and decreases in anti-desmoglein antibodies were observed. No serious adverse events were reported, although one study noted treatment failure, possibly due to short follow-up or concurrent infections. Apremilast appears to be a promising treatment for therapy-resistant or corticosteroid-intolerant pemphigus patients. Although the evidence is limited, it supports apremilast's efficacy and favorable safety profile. Further research with larger sample sizes and randomized controlled trials is necessary to confirm these findings.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-05Epub Date: 2025-03-27DOI: 10.4081/dr.2025.10289
Lulwa Alogayel, Sara Alrashid, Renad AlKanaan, Raneem Alnajjar, Ghaida Almarshoud
Nevus of Ota and nevus flammeus are distinct congenital pigmentary and vascular anomalies, respectively, with different etiologies and clinical implications. While both conditions can present unilaterally, their bilateral coexistence is rare. We report a 39-year-old Filipino female with a medical history of type 2 diabetes mellitus and dyslipidemia who presented to the dermatology clinic with concerns over a newly appearing benign nevus on the sole of her hand. Incidentally, dermatological examination revealed two significant congenital pigmentary lesions: bilateral nevus of Ota and a widespread nevus flammeus. The nevus of Ota manifested as well-defined blue-gray macules and patches symmetrically distributed across her face, involving both nasal nostrils and conjunctiva. The nevus flammeus, a congenital vascular malformation commonly known as a port-wine stain, extended over both arms, the upper back, and the chest, presenting as a well-demarcated reddish-purple discoloration. These lesions had been present since birth, remained asymptomatic, and had never been previously evaluated. No systemic involvement was detected, and laboratory investigations were unremarkable. The diagnosis was made clinically. As the patient was not interested in treating the nevi, no treatment was planned. This case highlights the importance of obtaining a detailed family history in all similar cases to aid in understanding the genetic basis of these conditions and their potential coexistence with other congenital dermal anomalies.
{"title":"Bilateral nevus of Ota in association with nevus flammeus: a case report.","authors":"Lulwa Alogayel, Sara Alrashid, Renad AlKanaan, Raneem Alnajjar, Ghaida Almarshoud","doi":"10.4081/dr.2025.10289","DOIUrl":"10.4081/dr.2025.10289","url":null,"abstract":"<p><p>Nevus of Ota and nevus flammeus are distinct congenital pigmentary and vascular anomalies, respectively, with different etiologies and clinical implications. While both conditions can present unilaterally, their bilateral coexistence is rare. We report a 39-year-old Filipino female with a medical history of type 2 diabetes mellitus and dyslipidemia who presented to the dermatology clinic with concerns over a newly appearing benign nevus on the sole of her hand. Incidentally, dermatological examination revealed two significant congenital pigmentary lesions: bilateral nevus of Ota and a widespread nevus flammeus. The nevus of Ota manifested as well-defined blue-gray macules and patches symmetrically distributed across her face, involving both nasal nostrils and conjunctiva. The nevus flammeus, a congenital vascular malformation commonly known as a port-wine stain, extended over both arms, the upper back, and the chest, presenting as a well-demarcated reddish-purple discoloration. These lesions had been present since birth, remained asymptomatic, and had never been previously evaluated. No systemic involvement was detected, and laboratory investigations were unremarkable. The diagnosis was made clinically. As the patient was not interested in treating the nevi, no treatment was planned. This case highlights the importance of obtaining a detailed family history in all similar cases to aid in understanding the genetic basis of these conditions and their potential coexistence with other congenital dermal anomalies.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12670374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-05Epub Date: 2025-04-24DOI: 10.4081/dr.2025.10167
Ronak S Ahmed, Rebaz M Ali, Shvan O Siddiq, Sana B Abdullah, Khanda A Anwar, Ari M Abdullah, Imad J Habibullah, Hawkar A Nasralla, Sasan M Ahmed, Sanaa O Karim, Fahmi H Kakamad
Myiasis is derived from the Greek word "myia", which means "fly". Zumpt, a German entomologist, defined this condition as the infestation of living humans and vertebrate animals by dipterous larvae that feed on living and dead host tissue, liquid body substances, or ingested food for a certain period. Myiasis is a rare complication that can occur in advanced squamous cell carcinoma (SCC). This report describes a rare cutaneous SCC of the face complicated by myiasis. A 70-year-old male patient presented with cutaneous SCC that involved the left lateral side of the nose, medial canthus, and left lower eyelid. The patient complained of multiple live maggots crawling out from a large wound. The larvae were isolated, examined microscopically, and identified as Dermatobia spp. The patient was treated with ivermectin, albendazole, and clindamycin, which were associated with the mechanical removal of the larvae. In the past decade, several case reports have described instances of cutaneous myiasis in head and neck malignancies. These cases were primarily linked to squamous cell carcinoma and involved patients over the age of 60. Additionally, the majority of the reported cases were from India. Myiasis can complicate SCC, particularly in patients who refuse treatment. Combining ivermectin, albendazole, and clindamycin may be a practical approach to managing myiasis.
{"title":"Cutaneous myiasis complicating squamous cell carcinoma: a case report with literature review.","authors":"Ronak S Ahmed, Rebaz M Ali, Shvan O Siddiq, Sana B Abdullah, Khanda A Anwar, Ari M Abdullah, Imad J Habibullah, Hawkar A Nasralla, Sasan M Ahmed, Sanaa O Karim, Fahmi H Kakamad","doi":"10.4081/dr.2025.10167","DOIUrl":"10.4081/dr.2025.10167","url":null,"abstract":"<p><p>Myiasis is derived from the Greek word \"myia\", which means \"fly\". Zumpt, a German entomologist, defined this condition as the infestation of living humans and vertebrate animals by dipterous larvae that feed on living and dead host tissue, liquid body substances, or ingested food for a certain period. Myiasis is a rare complication that can occur in advanced squamous cell carcinoma (SCC). This report describes a rare cutaneous SCC of the face complicated by myiasis. A 70-year-old male patient presented with cutaneous SCC that involved the left lateral side of the nose, medial canthus, and left lower eyelid. The patient complained of multiple live maggots crawling out from a large wound. The larvae were isolated, examined microscopically, and identified as Dermatobia spp. The patient was treated with ivermectin, albendazole, and clindamycin, which were associated with the mechanical removal of the larvae. In the past decade, several case reports have described instances of cutaneous myiasis in head and neck malignancies. These cases were primarily linked to squamous cell carcinoma and involved patients over the age of 60. Additionally, the majority of the reported cases were from India. Myiasis can complicate SCC, particularly in patients who refuse treatment. Combining ivermectin, albendazole, and clindamycin may be a practical approach to managing myiasis.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-05Epub Date: 2025-04-15DOI: 10.4081/dr.2025.10199
Laura Gnesotto, Mario Cutrone, Giuseppe Ruggiero, Carla Morando, Anna Belloni Fortina, Annalisa Patrizi, Luigi Naldi, Andrea Sechi
Focal facial dermal dysplasias (FFDDs) encompass four rare inherited disorders. FFDD types I, II, and III are characterized by bitemporal scar-like lesions present from birth, while FFDD IV is identified by analogous lesions localized in the periauricular area. Most FFDD IV cases show autosomal-recessive inheritance with mutations in the CYP26C1 gene. We describe three infants with bilateral, oval-shaped, hypopigmented preauricular lesions indicative of FFDD IV. It is crucial for physicians to recognize these rare conditions at an early stage to ensure proper diagnosis and to rule out associated malformations.
{"title":"Focal facial dermal dysplasia type IV: a case series.","authors":"Laura Gnesotto, Mario Cutrone, Giuseppe Ruggiero, Carla Morando, Anna Belloni Fortina, Annalisa Patrizi, Luigi Naldi, Andrea Sechi","doi":"10.4081/dr.2025.10199","DOIUrl":"10.4081/dr.2025.10199","url":null,"abstract":"<p><p>Focal facial dermal dysplasias (FFDDs) encompass four rare inherited disorders. FFDD types I, II, and III are characterized by bitemporal scar-like lesions present from birth, while FFDD IV is identified by analogous lesions localized in the periauricular area. Most FFDD IV cases show autosomal-recessive inheritance with mutations in the CYP26C1 gene. We describe three infants with bilateral, oval-shaped, hypopigmented preauricular lesions indicative of FFDD IV. It is crucial for physicians to recognize these rare conditions at an early stage to ensure proper diagnosis and to rule out associated malformations.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12777940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-05Epub Date: 2025-05-09DOI: 10.4081/dr.2025.10266
Mariateresa Rossi, Benedetta Galli, Grazia Linda Artelli, Laura Grigolato, Piergiacomo Calzavara-Pinton
Deep cutaneous and subcutaneous infections caused by dermatophytes are exceptionally uncommon, typically occurring through traumatic inoculation. This clinical report details the complex dermatological journey of a young, immunocompetent 24-year-old girl who reported a rare case of a subcutaneous mycosis caused by Microsporum gypseum. The patient presented with an annular erythematous plaque with centered papules on her left hand, which she referred to as stemming from an insect bite. Initial evaluation at another hospital included a biopsy, which resulted in a preliminary diagnosis of pyoderma gangrenosum. Appropriate treatment with topical steroids and later oral cyclosporine provided no response, leading clinicians to perform a new biopsy and cultural examination; the patient was diagnosed with epidermomycosis and pustular folliculitis caused by M. gypseum, a geophilic dermatophyte. In our patient's case, terbinafine proved effective, resulting in complete remission. This article aims to emphasize the importance of considering rare conditions such as subcutaneous epidermomycosis when the patient's medical history provides suggestive clues, particularly if the clinical manifestation aligns with the hypothesis.
{"title":"Beyond the surface: an uncommon case of <i>Microsporum gypseum</i> subcutaneous mycosis induced by an insect bite.","authors":"Mariateresa Rossi, Benedetta Galli, Grazia Linda Artelli, Laura Grigolato, Piergiacomo Calzavara-Pinton","doi":"10.4081/dr.2025.10266","DOIUrl":"10.4081/dr.2025.10266","url":null,"abstract":"<p><p>Deep cutaneous and subcutaneous infections caused by dermatophytes are exceptionally uncommon, typically occurring through traumatic inoculation. This clinical report details the complex dermatological journey of a young, immunocompetent 24-year-old girl who reported a rare case of a subcutaneous mycosis caused by Microsporum gypseum. The patient presented with an annular erythematous plaque with centered papules on her left hand, which she referred to as stemming from an insect bite. Initial evaluation at another hospital included a biopsy, which resulted in a preliminary diagnosis of pyoderma gangrenosum. Appropriate treatment with topical steroids and later oral cyclosporine provided no response, leading clinicians to perform a new biopsy and cultural examination; the patient was diagnosed with epidermomycosis and pustular folliculitis caused by M. gypseum, a geophilic dermatophyte. In our patient's case, terbinafine proved effective, resulting in complete remission. This article aims to emphasize the importance of considering rare conditions such as subcutaneous epidermomycosis when the patient's medical history provides suggestive clues, particularly if the clinical manifestation aligns with the hypothesis.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12777943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-05Epub Date: 2025-04-03DOI: 10.4081/dr.2025.10191
Wioleta Faruga-Lewicka, Małgorzata Dudek, Wiktoria Staśkiewicz-Bartecka, Marek Kardas
Acne vulgaris is a common inflammatory dermatosis and the most prevalent disorder of the pilosebaceous unit. It primarily affects the face and has an estimated global prevalence of about 9.4%. Many patients treated for acne vulgaris experience symptoms of anxiety, depression, and social withdrawal, often accompanied by feelings such as anger. This can be particularly exacerbated when dermatological treatment fails to have the expected effect. Given the significant psychosocial effects of the aforementioned dermatosis, early intervention is crucial. The survey was conducted between September 2023 and July 2024. The participants were patients at a cosmetology and aesthetic medicine clinic in Katowice, Poland. The Teenagers' Quality of Life Index (T-QoL) and Rosenberg Self-Esteem Scale (RSES) were used to conduct the survey. The study confirmed the significant impact of acne vulgaris on psycho-social aspects in women of different ages. Acne significantly lowers self-esteem and negatively affects the sufferers' perception of themselves and their appearance. The impact was shown to be more severe in a group of women over 27 years of age, who exhibited lower self-esteem compared to the younger group. Women with acne often feel the need to hide skin lesions and pay a lot of attention to their appearance, which can lead to reduced quality of life and emotional disturbances. A significant number of women have disturbed self-esteem and negative beliefs about themselves, which may be related to current beauty canons and social pressure for an unblemished appearance. The study underscores the need for a holistic approach to female patients with acne vulgaris, considering both medical and psychological aspects, in order to effectively treat and improve psychological well-being.
{"title":"Self-esteem, self-perception, and self-image of women with acne vulgaris at different age ranges.","authors":"Wioleta Faruga-Lewicka, Małgorzata Dudek, Wiktoria Staśkiewicz-Bartecka, Marek Kardas","doi":"10.4081/dr.2025.10191","DOIUrl":"10.4081/dr.2025.10191","url":null,"abstract":"<p><p>Acne vulgaris is a common inflammatory dermatosis and the most prevalent disorder of the pilosebaceous unit. It primarily affects the face and has an estimated global prevalence of about 9.4%. Many patients treated for acne vulgaris experience symptoms of anxiety, depression, and social withdrawal, often accompanied by feelings such as anger. This can be particularly exacerbated when dermatological treatment fails to have the expected effect. Given the significant psychosocial effects of the aforementioned dermatosis, early intervention is crucial. The survey was conducted between September 2023 and July 2024. The participants were patients at a cosmetology and aesthetic medicine clinic in Katowice, Poland. The Teenagers' Quality of Life Index (T-QoL) and Rosenberg Self-Esteem Scale (RSES) were used to conduct the survey. The study confirmed the significant impact of acne vulgaris on psycho-social aspects in women of different ages. Acne significantly lowers self-esteem and negatively affects the sufferers' perception of themselves and their appearance. The impact was shown to be more severe in a group of women over 27 years of age, who exhibited lower self-esteem compared to the younger group. Women with acne often feel the need to hide skin lesions and pay a lot of attention to their appearance, which can lead to reduced quality of life and emotional disturbances. A significant number of women have disturbed self-esteem and negative beliefs about themselves, which may be related to current beauty canons and social pressure for an unblemished appearance. The study underscores the need for a holistic approach to female patients with acne vulgaris, considering both medical and psychological aspects, in order to effectively treat and improve psychological well-being.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-05Epub Date: 2025-04-22DOI: 10.4081/dr.2025.10265
Thi Xuan Tam Huynh, Long Phan Son
This study explores the single-nucleotide polymorphism (SNP) variants rs2304365 and rs4074067 in the ST18 gene and their relationship with clinical manifestations of pemphigus vulgaris (PV) in Vietnamese patients. A case series was conducted with PV patients treated from March to October 2023 at the Ho Chi Minh City Hospital of Dermato-Venereology (Vietnam). Clinical data and patient histories were documented. Blood samples (2 mL) were analyzed for SNP variants rs2304365 and rs4074067 using Sanger sequencing at the Biomedical Research Center, Pham Ngoc Thach University of Medicine. Among 34 patients, two alleles, C and T, were identified in both SNPs. For rs2304365, allele C accounted for 91.2% and T for 8.8%. In rs4074067, allele C constituted 88.2% and T 11.8%. Patients carrying the T allele in rs2304365 exhibited moderate to severe disease. Additionally, the T allele in either SNP was associated with higher Pemphigus Disease Area Index (PDAI) scores compared to the C allele. SNP variants rs2304365 and rs4074067 in the ST18 gene may influence disease severity in PV among Vietnamese patients, underscoring the need for further research into their role in personalized treatment strategies.
{"title":"Genetic variations in the <i>ST18</i> gene and their association with pemphigus vulgaris in Vietnamese patients: insights from a case series.","authors":"Thi Xuan Tam Huynh, Long Phan Son","doi":"10.4081/dr.2025.10265","DOIUrl":"10.4081/dr.2025.10265","url":null,"abstract":"<p><p>This study explores the single-nucleotide polymorphism (SNP) variants rs2304365 and rs4074067 in the ST18 gene and their relationship with clinical manifestations of pemphigus vulgaris (PV) in Vietnamese patients. A case series was conducted with PV patients treated from March to October 2023 at the Ho Chi Minh City Hospital of Dermato-Venereology (Vietnam). Clinical data and patient histories were documented. Blood samples (2 mL) were analyzed for SNP variants rs2304365 and rs4074067 using Sanger sequencing at the Biomedical Research Center, Pham Ngoc Thach University of Medicine. Among 34 patients, two alleles, C and T, were identified in both SNPs. For rs2304365, allele C accounted for 91.2% and T for 8.8%. In rs4074067, allele C constituted 88.2% and T 11.8%. Patients carrying the T allele in rs2304365 exhibited moderate to severe disease. Additionally, the T allele in either SNP was associated with higher Pemphigus Disease Area Index (PDAI) scores compared to the C allele. SNP variants rs2304365 and rs4074067 in the ST18 gene may influence disease severity in PV among Vietnamese patients, underscoring the need for further research into their role in personalized treatment strategies.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dear Editor, Atrophic lichen sclerosus (ALS) is a chronic inflammatory dermatosis with significant morbidity, primarily affecting the genital area. The disease is often misdiagnosed or underdiagnosed, resulting in delayed treatment and progression to atrophic stages and permanent scars. While corticosteroids remain the first-line treatment, their long-term use may lead to adverse effects such as skin atrophy, prompting the need for alternative therapies. [...].
{"title":"Cutting-edge insights: line-field confocal optical coherence tomography and 5% cyclosporine for early lichen sclerosus treatment.","authors":"Caterina Mariarosaria Giorgio, Vittorio Tancredi, Gaetano Licata, Elvira Moscarella, Giuseppe Argenziano, Elisabetta Fulgione, Graziella Babino, Paolino Franzese, Eugenia Veronica Di Brizzi","doi":"10.4081/dr.2025.10279","DOIUrl":"10.4081/dr.2025.10279","url":null,"abstract":"<p><p>Dear Editor, Atrophic lichen sclerosus (ALS) is a chronic inflammatory dermatosis with significant morbidity, primarily affecting the genital area. The disease is often misdiagnosed or underdiagnosed, resulting in delayed treatment and progression to atrophic stages and permanent scars. While corticosteroids remain the first-line treatment, their long-term use may lead to adverse effects such as skin atrophy, prompting the need for alternative therapies. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-05Epub Date: 2025-04-11DOI: 10.4081/dr.2025.10342
Caterina Mariarosaria Giorgio, Gaetano Licata, Eugenia Veronica Di Brizzi, Graziella Babino, Elisabetta Fulgione, Elvira Moscarella, Giuseppe Lodi, Nicola Maria Giorgio, Vittorio Tancredi, Giuseppe Argenziano, Adone Baroni
Skin aging is characterized by loss of elasticity, wrinkles, and textural changes. Treatments range from non-invasive options, such as alpha-hydroxy acids and retinoic acid, to invasive procedures like chemical peels and laser therapies. Plasma radiofrequency (PRF) offers a minimally invasive solution with a favorable balance of efficacy and tolerability. This study assessed the clinical and microscopic outcomes of combining PRF ablation with a galenic cream containing 5% resorcinol in NourivanTM Antiox for facial skin aging. Forty-one patients with visible signs of aging underwent a single PRF session followed by weekly applications of a 5% resorcinol cream for six weeks. Outcomes were evaluated using digital photography and line-field confocal optical coherence tomography (LC-OCT) at baseline, three months, and six months. Primary endpoints included wrinkle reduction and texture improvement; secondary endpoints included adverse effects and patient satisfaction. At six months, 92% of patients showed significant wrinkle reduction and improved collagen organization in LC-OCT images. Skin texture improvements were reported by 85% of patients. Adverse effects, such as mild erythema and peeling, were transient and resolved without discontinuation. PRF ablation combined with 5% resorcinol cream is an effective and well-tolerated treatment for facial skin aging, offering significant improvements in skin texture and appearance. Further research is needed to confirm these findings and explore long-term effects.
{"title":"Facial skin rejuvenation through plasma radiofrequency ablation combined with 5% resorcinol cream: clinical and line-field confocal optical coherence tomography evaluation.","authors":"Caterina Mariarosaria Giorgio, Gaetano Licata, Eugenia Veronica Di Brizzi, Graziella Babino, Elisabetta Fulgione, Elvira Moscarella, Giuseppe Lodi, Nicola Maria Giorgio, Vittorio Tancredi, Giuseppe Argenziano, Adone Baroni","doi":"10.4081/dr.2025.10342","DOIUrl":"10.4081/dr.2025.10342","url":null,"abstract":"<p><p>Skin aging is characterized by loss of elasticity, wrinkles, and textural changes. Treatments range from non-invasive options, such as alpha-hydroxy acids and retinoic acid, to invasive procedures like chemical peels and laser therapies. Plasma radiofrequency (PRF) offers a minimally invasive solution with a favorable balance of efficacy and tolerability. This study assessed the clinical and microscopic outcomes of combining PRF ablation with a galenic cream containing 5% resorcinol in NourivanTM Antiox for facial skin aging. Forty-one patients with visible signs of aging underwent a single PRF session followed by weekly applications of a 5% resorcinol cream for six weeks. Outcomes were evaluated using digital photography and line-field confocal optical coherence tomography (LC-OCT) at baseline, three months, and six months. Primary endpoints included wrinkle reduction and texture improvement; secondary endpoints included adverse effects and patient satisfaction. At six months, 92% of patients showed significant wrinkle reduction and improved collagen organization in LC-OCT images. Skin texture improvements were reported by 85% of patients. Adverse effects, such as mild erythema and peeling, were transient and resolved without discontinuation. PRF ablation combined with 5% resorcinol cream is an effective and well-tolerated treatment for facial skin aging, offering significant improvements in skin texture and appearance. Further research is needed to confirm these findings and explore long-term effects.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12628655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study was to evaluate the quality of life (QoL) and psychosocial burden in adult Greek patients with atopic dermatitis (AD) using validated tools and to investigate factors that influence AD's humanistic burden. This observational, cross-sectional study was conducted in Greece (January-September 2023) with 150 adult members of the patient association "Epidermia", all diagnosed with AD. Data was collected through a structured questionnaire, including socio-demographic details, clinical history, AD severity (using the Patient-Oriented Eczema Measure [POEM]), QoL, sleep disorders, and psychological health. Based on POEM scores, 11% of participants had clear/almost clear skin, 27% had mild eczema, 51% had moderate eczema, and 12% had severe/very severe eczema. AD had a moderate or very/extremely large impact on QoL for 29% and 42% of participants, respectively. Insomnia affected 55%, while 31% had mild anxiety, 23% had moderate/severe anxiety, 10% had moderate depression, and 8% had moderately severe/severe depression. AD severity was associated with reduced QoL and higher rates of insomnia, anxiety, and depression. Our study highlights significant associations between AD severity, QoL, and psychosocial factors, emphasizing the need for comprehensive management strategies.
{"title":"The humanistic burden of atopic dermatitis in Greece: a cross-sectional study.","authors":"Georgia Kourlaba, Katerina Lioliou, Garyfallia Stefanou, Soultana Koukopoulou, Eirinaios Vamvakousis, Dimitrios Ioannides","doi":"10.4081/dr.2025.10164","DOIUrl":"10.4081/dr.2025.10164","url":null,"abstract":"<p><p>The purpose of this study was to evaluate the quality of life (QoL) and psychosocial burden in adult Greek patients with atopic dermatitis (AD) using validated tools and to investigate factors that influence AD's humanistic burden. This observational, cross-sectional study was conducted in Greece (January-September 2023) with 150 adult members of the patient association \"Epidermia\", all diagnosed with AD. Data was collected through a structured questionnaire, including socio-demographic details, clinical history, AD severity (using the Patient-Oriented Eczema Measure [POEM]), QoL, sleep disorders, and psychological health. Based on POEM scores, 11% of participants had clear/almost clear skin, 27% had mild eczema, 51% had moderate eczema, and 12% had severe/very severe eczema. AD had a moderate or very/extremely large impact on QoL for 29% and 42% of participants, respectively. Insomnia affected 55%, while 31% had mild anxiety, 23% had moderate/severe anxiety, 10% had moderate depression, and 8% had moderately severe/severe depression. AD severity was associated with reduced QoL and higher rates of insomnia, anxiety, and depression. Our study highlights significant associations between AD severity, QoL, and psychosocial factors, emphasizing the need for comprehensive management strategies.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12670372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}