F. Zamagni, F. Falcini, S. Magi, L. Bucchi, S. Mancini, R. Vattiato, E. Crocetti, S. Falcinelli, Claudio Feliciani, Maurizio Lombardo, D. Melandri, M. Pizzichetta, P. Re, Francesco Ricci, Rosanna Rita Satta, S. Gandini, I. Stanganelli, Fad MelaMEd Working Group
Introduction. According to the National Oncological Plan 2023-2027 on the importance of multidisciplinary and interactive e-learning training, the Italian Melanoma Intergroup (IMI) has developed MelaMEd (Melanoma Multimedia Education), a national project for general practitioners (GPs) on the prevention and detection of cutaneous melanoma through an online platform and an online course. MelaMEd enables participants to (1) recognize skin lesions that require specialist dermatological assessment, (2) select patients at high risk of melanoma and (3) be informed of the diagnosis and treatment pathway of patients with melanoma. Methods. A free online platform and online course were developed and launched in June 2022. Before starting the course, enrolled participants fill out a pre-training questionnaire concerning the basic knowledge of the disease and the recognition and management of suspicious lesions. After the course, participants will fill out the same questionnaire again. The online course will end in December 2023. Here we present a preliminary analysis of the pre-training results (January 2023-July 2023). The data have been analyzed descriptively. Results. So far, five healthcare centers have participated in the project for a total of 1320 participants. Of these, 298 compiled the pre-training questionnaire. Forty-seven percent of them were aged <40 years. Respondents were almost divided between GPs (47%) and resident GPs (48%). Among the theoretical questions, the “ABCDE” rule and “ugly duckling” sign are well known (96% and 91% of correct answers, respectively), but a lower percentage (68%) of respondents knows the “EFG” rule for the recognition of nodular melanomas and the statement of Breslow thickness (29%). Regarding the series of clinical images of pigmented skin lesions and their management, the percentages rate of accuracy varied from 33% to 87%: melanoma (5 cases) ranges from 36% to 71%, melanocytic nevi (3 cases) from 33% to 84%, whereas the percentages rate of referral for dermatological evaluation varied from 44% to 99%. Melanoma cases referred to dermatologist ranges from 67% to 99%. Conclusions. This preliminary analysis on pre-training questionnaire mainly showed a lack of knowledge of the two major points of melanoma diagnosis (EFG) and management (Breslow thickness), as well as a low rate of participants. We will compare the proportions of correct answers to the questionnaires before and after the course once available.
{"title":"Preliminary analysis of the melanoma multimedia educational program for general practitioners on behalf of the Italian melanoma intergroup","authors":"F. Zamagni, F. Falcini, S. Magi, L. Bucchi, S. Mancini, R. Vattiato, E. Crocetti, S. Falcinelli, Claudio Feliciani, Maurizio Lombardo, D. Melandri, M. Pizzichetta, P. Re, Francesco Ricci, Rosanna Rita Satta, S. Gandini, I. Stanganelli, Fad MelaMEd Working Group","doi":"10.4081/dr.2024.9920","DOIUrl":"https://doi.org/10.4081/dr.2024.9920","url":null,"abstract":"Introduction. According to the National Oncological Plan 2023-2027 on the importance of multidisciplinary and interactive e-learning training, the Italian Melanoma Intergroup (IMI) has developed MelaMEd (Melanoma Multimedia Education), a national project for general practitioners (GPs) on the prevention and detection of cutaneous melanoma through an online platform and an online course. MelaMEd enables participants to (1) recognize skin lesions that require specialist dermatological assessment, (2) select patients at high risk of melanoma and (3) be informed of the diagnosis and treatment pathway of patients with melanoma. Methods. A free online platform and online course were developed and launched in June 2022. Before starting the course, enrolled participants fill out a pre-training questionnaire concerning the basic knowledge of the disease and the recognition and management of suspicious lesions. After the course, participants will fill out the same questionnaire again. The online course will end in December 2023. Here we present a preliminary analysis of the pre-training results (January 2023-July 2023). The data have been analyzed descriptively. Results. So far, five healthcare centers have participated in the project for a total of 1320 participants. Of these, 298 compiled the pre-training questionnaire. Forty-seven percent of them were aged <40 years. Respondents were almost divided between GPs (47%) and resident GPs (48%). Among the theoretical questions, the “ABCDE” rule and “ugly duckling” sign are well known (96% and 91% of correct answers, respectively), but a lower percentage (68%) of respondents knows the “EFG” rule for the recognition of nodular melanomas and the statement of Breslow thickness (29%). Regarding the series of clinical images of pigmented skin lesions and their management, the percentages rate of accuracy varied from 33% to 87%: melanoma (5 cases) ranges from 36% to 71%, melanocytic nevi (3 cases) from 33% to 84%, whereas the percentages rate of referral for dermatological evaluation varied from 44% to 99%. Melanoma cases referred to dermatologist ranges from 67% to 99%. Conclusions. This preliminary analysis on pre-training questionnaire mainly showed a lack of knowledge of the two major points of melanoma diagnosis (EFG) and management (Breslow thickness), as well as a low rate of participants. We will compare the proportions of correct answers to the questionnaires before and after the course once available.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12eCollection Date: 2024-03-12DOI: 10.4081/dr.2023.9875
Ernesto De Piano, Pietro Rubegni, Francesca Falcinelli
{"title":"Over-rotated Rieger flap for a large lateral nasal tip defect reconstruction.","authors":"Ernesto De Piano, Pietro Rubegni, Francesca Falcinelli","doi":"10.4081/dr.2023.9875","DOIUrl":"https://doi.org/10.4081/dr.2023.9875","url":null,"abstract":"","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10993645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Stanganelli, S. Magi, L. Bucchi, E. Crocetti, S. Mancini, R. Vattiato, S. Falcinelli, P. Re, D. Melandri, M. Brusasco, S. Gandini, F. Falcini, F. Zamagni, Fad MelaMEd Working Group
The text discusses the role of general practitioners (GPs) in the prevention and early diagnosis of melanoma, a type of skin cancer. It highlights the need for GPs to be able to recognize suspicious skin lesions and refer patients to specialist dermatology centers. However, many GPs lack comprehensive training in diagnosing melanoma. The text mentions that various training courses have been conducted for GPs, but their impact on clinical practice has been limited. The "MelaMEd Programme" is an e-learning course developed by the Italian Melanoma Intergroup (IMI). The program aims to provide GPs with comprehensive knowledge of melanoma prevention, diagnosis, and treatment. It includes an e-learning section and a dedicated platform called MelaMEd platform, which offers a multimedia atlas of melanoma. The objective of the study is to evaluate the impact of the MelaMEd programme on GPs' diagnostic accuracy, knowledge of melanoma, and management of suspicious lesions. The methodology involves administering pre-training and post-training questionnaires to participants, assessing their diagnostic skills and evaluating the training course's effectiveness. The study aims to demonstrate the effectiveness of the MelaMEd programme in improving GPs' ability to recognize and manage melanoma. It also seeks to identify areas for improvement and recommend interventions to enhance diagnostic accuracy. The results will be analyzed statistically using descriptive, univariate, and multivariate analysis methods.
{"title":"Evaluation of a training course for general practitioners within the melanoma multimedia education program of the Italian melanoma intergroup: study protocol","authors":"I. Stanganelli, S. Magi, L. Bucchi, E. Crocetti, S. Mancini, R. Vattiato, S. Falcinelli, P. Re, D. Melandri, M. Brusasco, S. Gandini, F. Falcini, F. Zamagni, Fad MelaMEd Working Group","doi":"10.4081/dr.2024.9919","DOIUrl":"https://doi.org/10.4081/dr.2024.9919","url":null,"abstract":"The text discusses the role of general practitioners (GPs) in the prevention and early diagnosis of melanoma, a type of skin cancer. It highlights the need for GPs to be able to recognize suspicious skin lesions and refer patients to specialist dermatology centers. However, many GPs lack comprehensive training in diagnosing melanoma. The text mentions that various training courses have been conducted for GPs, but their impact on clinical practice has been limited. The \"MelaMEd Programme\" is an e-learning course developed by the Italian Melanoma Intergroup (IMI). The program aims to provide GPs with comprehensive knowledge of melanoma prevention, diagnosis, and treatment. It includes an e-learning section and a dedicated platform called MelaMEd platform, which offers a multimedia atlas of melanoma. The objective of the study is to evaluate the impact of the MelaMEd programme on GPs' diagnostic accuracy, knowledge of melanoma, and management of suspicious lesions. The methodology involves administering pre-training and post-training questionnaires to participants, assessing their diagnostic skills and evaluating the training course's effectiveness. The study aims to demonstrate the effectiveness of the MelaMEd programme in improving GPs' ability to recognize and manage melanoma. It also seeks to identify areas for improvement and recommend interventions to enhance diagnostic accuracy. The results will be analyzed statistically using descriptive, univariate, and multivariate analysis methods.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139788558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincenzo Maione, Laura Miccio, Sara Rovaris, Davide Zardo, S. Bighetti, L. Bettolini, Luigi Naldi
Eosinophilic Fasciitis (EF) poses a diagnostic challenge owing to its uncommon occurrence and aetiology that remains poorly understood. We report a case of a 79-year-old woman with a prolonged history of breast cancer exhibiting EF with concomitant pelvic metastases. This case underscores EF's potential as an indicator signaling a potential resurgence of cancer, highlighting its significance as a red flag of disease recurrence.
嗜酸性粒细胞性筋膜炎（Eosinophilic Fasciitis，EF）是一种诊断难题，因为它并不常见，而且病因至今仍不十分清楚。我们报告了一例 79 岁妇女的病例，她长期患有乳腺癌，表现为嗜酸性筋膜炎并伴有盆腔转移。该病例强调了 EF 作为癌症潜在复发信号指标的潜力，突出了其作为疾病复发红旗的重要性。
{"title":"Eosinophilic fasciitis and breast cancer: a case report highlighting recurrence signals","authors":"Vincenzo Maione, Laura Miccio, Sara Rovaris, Davide Zardo, S. Bighetti, L. Bettolini, Luigi Naldi","doi":"10.4081/dr.2024.9928","DOIUrl":"https://doi.org/10.4081/dr.2024.9928","url":null,"abstract":"Eosinophilic Fasciitis (EF) poses a diagnostic challenge owing to its uncommon occurrence and aetiology that remains poorly understood. We report a case of a 79-year-old woman with a prolonged history of breast cancer exhibiting EF with concomitant pelvic metastases. This case underscores EF's potential as an indicator signaling a potential resurgence of cancer, highlighting its significance as a red flag of disease recurrence.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139847891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Stanganelli, S. Magi, L. Bucchi, E. Crocetti, S. Mancini, R. Vattiato, S. Falcinelli, P. Re, D. Melandri, M. Brusasco, S. Gandini, F. Falcini, F. Zamagni, Fad MelaMEd Working Group
The text discusses the role of general practitioners (GPs) in the prevention and early diagnosis of melanoma, a type of skin cancer. It highlights the need for GPs to be able to recognize suspicious skin lesions and refer patients to specialist dermatology centers. However, many GPs lack comprehensive training in diagnosing melanoma. The text mentions that various training courses have been conducted for GPs, but their impact on clinical practice has been limited. The "MelaMEd Programme" is an e-learning course developed by the Italian Melanoma Intergroup (IMI). The program aims to provide GPs with comprehensive knowledge of melanoma prevention, diagnosis, and treatment. It includes an e-learning section and a dedicated platform called MelaMEd platform, which offers a multimedia atlas of melanoma. The objective of the study is to evaluate the impact of the MelaMEd programme on GPs' diagnostic accuracy, knowledge of melanoma, and management of suspicious lesions. The methodology involves administering pre-training and post-training questionnaires to participants, assessing their diagnostic skills and evaluating the training course's effectiveness. The study aims to demonstrate the effectiveness of the MelaMEd programme in improving GPs' ability to recognize and manage melanoma. It also seeks to identify areas for improvement and recommend interventions to enhance diagnostic accuracy. The results will be analyzed statistically using descriptive, univariate, and multivariate analysis methods.
{"title":"Evaluation of a training course for general practitioners within the melanoma multimedia education program of the Italian melanoma intergroup: study protocol","authors":"I. Stanganelli, S. Magi, L. Bucchi, E. Crocetti, S. Mancini, R. Vattiato, S. Falcinelli, P. Re, D. Melandri, M. Brusasco, S. Gandini, F. Falcini, F. Zamagni, Fad MelaMEd Working Group","doi":"10.4081/dr.2024.9919","DOIUrl":"https://doi.org/10.4081/dr.2024.9919","url":null,"abstract":"The text discusses the role of general practitioners (GPs) in the prevention and early diagnosis of melanoma, a type of skin cancer. It highlights the need for GPs to be able to recognize suspicious skin lesions and refer patients to specialist dermatology centers. However, many GPs lack comprehensive training in diagnosing melanoma. The text mentions that various training courses have been conducted for GPs, but their impact on clinical practice has been limited. The \"MelaMEd Programme\" is an e-learning course developed by the Italian Melanoma Intergroup (IMI). The program aims to provide GPs with comprehensive knowledge of melanoma prevention, diagnosis, and treatment. It includes an e-learning section and a dedicated platform called MelaMEd platform, which offers a multimedia atlas of melanoma. The objective of the study is to evaluate the impact of the MelaMEd programme on GPs' diagnostic accuracy, knowledge of melanoma, and management of suspicious lesions. The methodology involves administering pre-training and post-training questionnaires to participants, assessing their diagnostic skills and evaluating the training course's effectiveness. The study aims to demonstrate the effectiveness of the MelaMEd programme in improving GPs' ability to recognize and manage melanoma. It also seeks to identify areas for improvement and recommend interventions to enhance diagnostic accuracy. The results will be analyzed statistically using descriptive, univariate, and multivariate analysis methods.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincenzo Maione, Laura Miccio, Sara Rovaris, Davide Zardo, S. Bighetti, L. Bettolini, Luigi Naldi
Eosinophilic Fasciitis (EF) poses a diagnostic challenge owing to its uncommon occurrence and aetiology that remains poorly understood. We report a case of a 79-year-old woman with a prolonged history of breast cancer exhibiting EF with concomitant pelvic metastases. This case underscores EF's potential as an indicator signaling a potential resurgence of cancer, highlighting its significance as a red flag of disease recurrence.
嗜酸性粒细胞性筋膜炎（Eosinophilic Fasciitis，EF）是一种诊断难题，因为它并不常见，而且病因至今仍不十分清楚。我们报告了一例 79 岁妇女的病例，她长期患有乳腺癌，表现为嗜酸性筋膜炎并伴有盆腔转移。该病例强调了 EF 作为癌症潜在复发信号指标的潜力，突出了其作为疾病复发红旗的重要性。
{"title":"Eosinophilic fasciitis and breast cancer: a case report highlighting recurrence signals","authors":"Vincenzo Maione, Laura Miccio, Sara Rovaris, Davide Zardo, S. Bighetti, L. Bettolini, Luigi Naldi","doi":"10.4081/dr.2024.9928","DOIUrl":"https://doi.org/10.4081/dr.2024.9928","url":null,"abstract":"Eosinophilic Fasciitis (EF) poses a diagnostic challenge owing to its uncommon occurrence and aetiology that remains poorly understood. We report a case of a 79-year-old woman with a prolonged history of breast cancer exhibiting EF with concomitant pelvic metastases. This case underscores EF's potential as an indicator signaling a potential resurgence of cancer, highlighting its significance as a red flag of disease recurrence.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139788073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Linear IgA Bullous Dermatosis (LABD) is a rare immune-mediated vesiculobullous disease that was reported to be induced by infections or medications. Atezolizumab is a monoclonal antibody targeting programmed cell death ligand-1 (PD-L1), it has been used to treat multiple cancers. Here, we report a case of drug induced LABD following the administration of Atezolizumab.
{"title":"Linear IgA bullous dermatosis induced by atezolizumab: a case report","authors":"Seba Almutairi, Dana Alessa","doi":"10.4081/dr.2024.9923","DOIUrl":"https://doi.org/10.4081/dr.2024.9923","url":null,"abstract":"Linear IgA Bullous Dermatosis (LABD) is a rare immune-mediated vesiculobullous disease that was reported to be induced by infections or medications. Atezolizumab is a monoclonal antibody targeting programmed cell death ligand-1 (PD-L1), it has been used to treat multiple cancers. Here, we report a case of drug induced LABD following the administration of Atezolizumab.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139852730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mitchell Hanson, McKenzie E. Maloney, Louis Kuchnir
Background: Erythema nodosum (EN) is inflammation of subcutaneous fat. Etiologies include autoimmune diseases, drugs, infections, pregnancy, malignancy, and idiopathic origins. Case: A 37- year-old female with a history of recurrent cellulitis and type II diabetes presented with worsening swollen lumps on upper extremities for four months during a Hurley Stage III hidradenitis suppurativa (HS) flare. Exam revealed multiple erythematous pustules and warm indurated nodules over diffuse edema on the upper extremities. Lesions were refractory to trimethoprim/sulfamethoxazole, cefalexin, clindamycin and levofloxacin. Routine blood labs, ESR, and ANA were unremarkable. EN was diagnosed. Trimethoprim/sulfamethoxazole, saturated solution potassium iodide (SSKI) and ibuprofen were prescribed. At three week follow-up, EN had completely resolved except for one lesion. Discussion: Literature review revealed one case of EN manifestation in association with HS but was complicated by Beçhet’s syndrome. We propose HS as an underlying cause of EN and SSKI an effective treatment for EN and HS.
背景：结节性红斑（EN结节性红斑（EN）是一种皮下脂肪炎症。病因包括自身免疫性疾病、药物、感染、妊娠、恶性肿瘤和特发性病因。病例：一名 37 岁的女性，曾患复发性蜂窝组织炎和 II 型糖尿病，在赫尔利化脓性扁桃体炎（HS）III 期复发期间，上肢肿块恶化达四个月之久。检查发现上肢弥漫性水肿上有多个红斑脓疱和温暖的凹陷性结节。三甲双胍/磺胺甲噁唑、头孢氨苄、克林霉素和左氧氟沙星均无效。血常规化验、血沉和ANA均无异常。EN 被确诊。医生给他开了三甲双氨/磺胺甲恶唑、饱和碘化钾溶液（SSKI）和布洛芬。随访三周后，除一处皮损外，EN已完全消退。讨论文献综述显示，有一例EN表现与HS有关，但因贝切氏综合征而并发。我们认为 HS 是导致 EN 的潜在原因，而 SSKI 是治疗 EN 和 HS 的有效方法。
{"title":"Exploring the connection between hidradenitis suppurativa and erythema nodosum: a case report","authors":"Mitchell Hanson, McKenzie E. Maloney, Louis Kuchnir","doi":"10.4081/dr.2024.9866","DOIUrl":"https://doi.org/10.4081/dr.2024.9866","url":null,"abstract":"Background: Erythema nodosum (EN) is inflammation of subcutaneous fat. Etiologies include autoimmune diseases, drugs, infections, pregnancy, malignancy, and idiopathic origins. Case: A 37- year-old female with a history of recurrent cellulitis and type II diabetes presented with worsening swollen lumps on upper extremities for four months during a Hurley Stage III hidradenitis suppurativa (HS) flare. Exam revealed multiple erythematous pustules and warm indurated nodules over diffuse edema on the upper extremities. Lesions were refractory to trimethoprim/sulfamethoxazole, cefalexin, clindamycin and levofloxacin. Routine blood labs, ESR, and ANA were unremarkable. EN was diagnosed. Trimethoprim/sulfamethoxazole, saturated solution potassium iodide (SSKI) and ibuprofen were prescribed. At three week follow-up, EN had completely resolved except for one lesion. Discussion: Literature review revealed one case of EN manifestation in association with HS but was complicated by Beçhet’s syndrome. We propose HS as an underlying cause of EN and SSKI an effective treatment for EN and HS.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139852133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mitchell Hanson, McKenzie E. Maloney, Louis Kuchnir
Background: Erythema nodosum (EN) is inflammation of subcutaneous fat. Etiologies include autoimmune diseases, drugs, infections, pregnancy, malignancy, and idiopathic origins. Case: A 37- year-old female with a history of recurrent cellulitis and type II diabetes presented with worsening swollen lumps on upper extremities for four months during a Hurley Stage III hidradenitis suppurativa (HS) flare. Exam revealed multiple erythematous pustules and warm indurated nodules over diffuse edema on the upper extremities. Lesions were refractory to trimethoprim/sulfamethoxazole, cefalexin, clindamycin and levofloxacin. Routine blood labs, ESR, and ANA were unremarkable. EN was diagnosed. Trimethoprim/sulfamethoxazole, saturated solution potassium iodide (SSKI) and ibuprofen were prescribed. At three week follow-up, EN had completely resolved except for one lesion. Discussion: Literature review revealed one case of EN manifestation in association with HS but was complicated by Beçhet’s syndrome. We propose HS as an underlying cause of EN and SSKI an effective treatment for EN and HS.
背景：结节性红斑（EN结节性红斑（EN）是一种皮下脂肪炎症。病因包括自身免疫性疾病、药物、感染、妊娠、恶性肿瘤和特发性病因。病例：一名 37 岁的女性，曾患复发性蜂窝组织炎和 II 型糖尿病，在赫尔利化脓性扁桃体炎（HS）III 期复发期间，上肢肿块恶化达四个月之久。检查发现上肢弥漫性水肿上有多个红斑脓疱和温暖的凹陷性结节。三甲双胍/磺胺甲噁唑、头孢氨苄、克林霉素和左氧氟沙星均无效。血常规化验、血沉和ANA均无异常。EN 被确诊。医生给他开了三甲双氨/磺胺甲恶唑、饱和碘化钾溶液（SSKI）和布洛芬。随访三周后，除一处皮损外，EN已完全消退。讨论文献综述显示，有一例EN表现与HS有关，但因贝切氏综合征而并发。我们认为 HS 是导致 EN 的潜在原因，而 SSKI 是治疗 EN 和 HS 的有效方法。
{"title":"Exploring the connection between hidradenitis suppurativa and erythema nodosum: a case report","authors":"Mitchell Hanson, McKenzie E. Maloney, Louis Kuchnir","doi":"10.4081/dr.2024.9866","DOIUrl":"https://doi.org/10.4081/dr.2024.9866","url":null,"abstract":"Background: Erythema nodosum (EN) is inflammation of subcutaneous fat. Etiologies include autoimmune diseases, drugs, infections, pregnancy, malignancy, and idiopathic origins. Case: A 37- year-old female with a history of recurrent cellulitis and type II diabetes presented with worsening swollen lumps on upper extremities for four months during a Hurley Stage III hidradenitis suppurativa (HS) flare. Exam revealed multiple erythematous pustules and warm indurated nodules over diffuse edema on the upper extremities. Lesions were refractory to trimethoprim/sulfamethoxazole, cefalexin, clindamycin and levofloxacin. Routine blood labs, ESR, and ANA were unremarkable. EN was diagnosed. Trimethoprim/sulfamethoxazole, saturated solution potassium iodide (SSKI) and ibuprofen were prescribed. At three week follow-up, EN had completely resolved except for one lesion. Discussion: Literature review revealed one case of EN manifestation in association with HS but was complicated by Beçhet’s syndrome. We propose HS as an underlying cause of EN and SSKI an effective treatment for EN and HS.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139792479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Linear IgA Bullous Dermatosis (LABD) is a rare immune-mediated vesiculobullous disease that was reported to be induced by infections or medications. Atezolizumab is a monoclonal antibody targeting programmed cell death ligand-1 (PD-L1), it has been used to treat multiple cancers. Here, we report a case of drug induced LABD following the administration of Atezolizumab.
{"title":"Linear IgA bullous dermatosis induced by atezolizumab: a case report","authors":"Seba Almutairi, Dana Alessa","doi":"10.4081/dr.2024.9923","DOIUrl":"https://doi.org/10.4081/dr.2024.9923","url":null,"abstract":"Linear IgA Bullous Dermatosis (LABD) is a rare immune-mediated vesiculobullous disease that was reported to be induced by infections or medications. Atezolizumab is a monoclonal antibody targeting programmed cell death ligand-1 (PD-L1), it has been used to treat multiple cancers. Here, we report a case of drug induced LABD following the administration of Atezolizumab.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139793000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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