Pub Date : 2022-10-25DOI: 10.2174/04666221025143641
Vaishnavi Bose, A. C. Thomas, Hazem Hussein, Sana Junaid, Nadeem Javed Younas
Enteric fever is a common infection found in many developing countries around the world, which often has life- threatening complications if not treated promptly. One of the rarest complications of enteric fever is splenic abscess. Our case is that of a 32-year-old male, admitted with febrile illness, diagnosed as typhoid fever (enteric fever) with rare complication- multiple splenic abscesses, after his travel to endemic area, which was effectively treated with antibiotics under inpatient setting. Early diagnosis with imaging modalities such as computed tomography can lead to better treatment approaches. Splenic abscesses are often treated with antibiotics or conservative treatment; however, non-responsive cases may require splenectomy.
{"title":"A Rare Case of Enteric Fever with Multiple Splenic Abscesses: Case Report","authors":"Vaishnavi Bose, A. C. Thomas, Hazem Hussein, Sana Junaid, Nadeem Javed Younas","doi":"10.2174/04666221025143641","DOIUrl":"https://doi.org/10.2174/04666221025143641","url":null,"abstract":"\u0000\u0000Enteric fever is a common infection found in many developing countries around the world, which often has life- threatening complications if not treated promptly. One of the rarest complications of enteric fever is splenic abscess.\u0000\u0000\u0000\u0000Our case is that of a 32-year-old male, admitted with febrile illness, diagnosed as typhoid fever (enteric fever) with rare complication- multiple splenic abscesses, after his travel to endemic area, which was effectively treated with antibiotics under inpatient setting.\u0000\u0000\u0000\u0000Early diagnosis with imaging modalities such as computed tomography can lead to better treatment approaches. Splenic abscesses are often treated with antibiotics or conservative treatment; however, non-responsive cases may require splenectomy.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134417296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-21DOI: 10.2174/04666221021150035
Zehdi Eydou, Hamza Wajeeh Issa, Theekshitha Kamalakannan, Biji Thomas George, Ahmed Maasher
Hernias containing the appendix are well-known entities that preferentially affect the groin. The presence of an appendix within a Spigelian hernia, which is a rare ventral hernia that presents with nonspecific symptoms and location, adds significantly to the complexity and rarity of its diagnosis. Further, only 18 such cases were reported and published in the literature. We report a case of Spigelian hernia and appendicitis within the hernial sac to highlight the diagnostic challenges associated with this type of hernia. In her late 30s, a female who underwent laparoscopic surgery for a uterine fibroid two and a half years back presented with right lower quadrant abdominal pain for two days. This followed abdominal pain on exertion for the previous nine months. On examination, there was tenderness, guarding, and a positive cough impulse in the right lower quadrant of the abdomen. Her body mass index was 37.53 kg/m2. A contrast-enhanced computed tomography imaging of the abdomen reported a right iliac fossa incisional hernia with omental congestion necessitating an emergency laparoscopic surgery. At surgery, a Spigelian hernia, which was at least 5 cm away from the port site scar of the previous surgery, was found. The hernia contained an inflamed appendix. Thus, a diagnosis of Spigelian hernia and appendicitis within the hernial sac was made. A laparoscopic reduction and repair of the Spigelian hernia and a laparoscopic appendectomy were performed. Whereas Spigelian hernias are considerably rare, the presence of an appendix within a Spigelian hernia sac is yet a more infrequent occurrence. Although the imaging modalities are often inconclusive, careful interpretation of the computed tomography imaging findings may reveal the pathology preoperatively.
{"title":"Spigelian Hernia and Appendicitis: A Rare Case Report.","authors":"Zehdi Eydou, Hamza Wajeeh Issa, Theekshitha Kamalakannan, Biji Thomas George, Ahmed Maasher","doi":"10.2174/04666221021150035","DOIUrl":"https://doi.org/10.2174/04666221021150035","url":null,"abstract":"\u0000\u0000Hernias containing the appendix are well-known entities that preferentially affect the groin. The presence of an appendix within a Spigelian hernia, which is a rare ventral hernia that presents with nonspecific symptoms and location, adds significantly to the complexity and rarity of its diagnosis. Further, only 18 such cases were reported and published in the literature. We report a case of Spigelian hernia and appendicitis within the hernial sac to highlight the diagnostic challenges associated with this type of hernia.\u0000\u0000\u0000\u0000In her late 30s, a female who underwent laparoscopic surgery for a uterine fibroid two and a half years back presented with right lower quadrant abdominal pain for two days. This followed abdominal pain on exertion for the previous nine months. On examination, there was tenderness, guarding, and a positive cough impulse in the right lower quadrant of the abdomen. Her body mass index was 37.53 kg/m2. A contrast-enhanced computed tomography imaging of the abdomen reported a right iliac fossa incisional hernia with omental congestion necessitating an emergency laparoscopic surgery. At surgery, a Spigelian hernia, which was at least 5 cm away from the port site scar of the previous surgery, was found. The hernia contained an inflamed appendix. Thus, a diagnosis of Spigelian hernia and appendicitis within the hernial sac was made. A laparoscopic reduction and repair of the Spigelian hernia and a laparoscopic appendectomy were performed.\u0000\u0000\u0000\u0000Whereas Spigelian hernias are considerably rare, the presence of an appendix within a Spigelian hernia sac is yet a more infrequent occurrence. Although the imaging modalities are often inconclusive, careful interpretation of the computed tomography imaging findings may reveal the pathology preoperatively.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127075036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-06DOI: 10.2174/03666221006083724
Ozlem Oz, Ataman Gonel
Differences in free beta HCG and PAPP-A values, which are among the biochemical parameters in the double screening test, is frequently used for pregnancy follow-up, allow aneuploidy and triploidy risk to be determined. In recent studies, it’s suggested that the modified hemogram indices have gained importance as a marker in the prognosis of diseases. In this study, we aimed to determine the hematological parameters, which are routinely applied in the first trimester of pregnancy, have any value in predicting the risk increase in the double screening test and in early diagnosis. Pregnant women who conceived spontaneously and had double screening tests were included in the study. CBC results that were studied together with the first trimester screening test were reported. The patients were divided into two groups according to the results of the screening test as the combined risk ratio. The mean age was found to be significantly higher in the high-risk group than in the low-risk group. Monocyte, % M and WBC values were significantly lower in the high-risk group (0,483±0,140, 5,58±1,44 and 8,75±2,12 , respectively). There was no significant difference in NLR and PLR values compared between the groups. MPV values were lower and PAPP-A, PAPP-A MoM values were significantly lower in high-risk group compared to the low-risk group. The findings support low Monocyte, % M and WBC values as a potential marker for the identification of the high risk pregnancy in otherwise healthy pregnant women. The results indicate that CBC parametres commonly used in pregnancy can be used to predict the prognosis.
{"title":"Are Monocyte, %M and WBC a Biomarker in the First Trimester Screening Test?","authors":"Ozlem Oz, Ataman Gonel","doi":"10.2174/03666221006083724","DOIUrl":"https://doi.org/10.2174/03666221006083724","url":null,"abstract":"\u0000\u0000Differences in free beta HCG and PAPP-A values, which are among the biochemical parameters in the double screening test, is frequently used for pregnancy follow-up, allow aneuploidy and triploidy risk to be determined. In recent studies, it’s suggested that the modified hemogram indices have gained importance as a marker in the prognosis of diseases.\u0000\u0000\u0000\u0000In this study, we aimed to determine the hematological parameters, which are routinely applied in the first trimester of pregnancy, have any value in predicting the risk increase in the double screening test and in early diagnosis.\u0000\u0000\u0000\u0000Pregnant women who conceived spontaneously and had double screening tests were included in the study. CBC results that were studied together with the first trimester screening test were reported. The patients were divided into two groups according to the results of the screening test as the combined risk ratio.\u0000\u0000\u0000\u0000The mean age was found to be significantly higher in the high-risk group than in the low-risk group. Monocyte, % M and WBC values were significantly lower in the high-risk group (0,483±0,140, 5,58±1,44 and 8,75±2,12 , respectively). There was no significant difference in NLR and PLR values compared between the groups. MPV values were lower and PAPP-A, PAPP-A MoM values were significantly lower in high-risk group compared to the low-risk group.\u0000\u0000\u0000\u0000The findings support low Monocyte, % M and WBC values as a potential marker for the identification of the high risk pregnancy in otherwise healthy pregnant women. The results indicate that CBC parametres commonly used in pregnancy can be used to predict the prognosis.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131490447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-21DOI: 10.2174/03666220921085212
S. Manzar
Fetal neurons are sensitive to ischemia which could happen secondary to acute maternal blood loss. The damage to the fetal brain with loss of brain neurons in early gestation leads to encephalomalacia. We describe here a case report of fetal encephalomalacia secondary to acute maternal blood loss. A 23-year-old gravida 3, para 2 woman sustained a forearm laceration at 18 weeks of gestation. Her hemoglobin dropped to 7.9 mg/dL. A surgical laceration repair was completed, and she was transfused with blood. At the OB visit the following week, her fetal US showed abnormal brain, evident by the increased size of the lateral ventricles. A follow-up MRI at 30 weeks of gestation confirmed fetal encephalomalacia. A complete investigation, including free cell maternal DNA for chromosomal anomalies, TORCH infection, and Covid PCR, all were negative. We concluded from the case that any history of significant acute maternal blood loss that required blood transfusion should necessitate a fetal ultrasound to look for fetal well-being, especially for any brain structural changes in the developing brain.
{"title":"Fetal Encephalomalacia Secondary to Acute Maternal Blood Loss: A Case Study","authors":"S. Manzar","doi":"10.2174/03666220921085212","DOIUrl":"https://doi.org/10.2174/03666220921085212","url":null,"abstract":"\u0000\u0000Fetal neurons are sensitive to ischemia which could happen secondary to acute maternal blood loss. The damage to the fetal brain with loss of brain\u0000neurons in early gestation leads to encephalomalacia. We describe here a case report of fetal encephalomalacia secondary to acute maternal blood\u0000loss.\u0000\u0000\u0000\u0000A 23-year-old gravida 3, para 2 woman sustained a forearm laceration at 18 weeks of gestation. Her hemoglobin dropped to 7.9 mg/dL. A surgical\u0000laceration repair was completed, and she was transfused with blood. At the OB visit the following week, her fetal US showed abnormal brain,\u0000evident by the increased size of the lateral ventricles. A follow-up MRI at 30 weeks of gestation confirmed fetal encephalomalacia. A complete\u0000investigation, including free cell maternal DNA for chromosomal anomalies, TORCH infection, and Covid PCR, all were negative.\u0000\u0000\u0000\u0000We concluded from the case that any history of significant acute maternal blood loss that required blood transfusion should necessitate a fetal\u0000ultrasound to look for fetal well-being, especially for any brain structural changes in the developing brain.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124531986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-21DOI: 10.2174/03666220921100058
N. Mohanty, D. Mohapatra, Shakti Rath
To determine the knowledge, attitude and practice of the use of nanoparticles amongst health care professionals for treating oral cancer patients. Also, to understand the indications and contraindications of nanoparticles in treating oral cancer patients. A descriptive cross-sectional study was executed amongst dental surgeons practising with undergraduate and post-graduate degrees. A Google questionnaire form was developed and distributed, and 102 authentic entries were short-listed. Data obtained from the study were recorded in Microsoft Excel 2007 version, and SPSS version 18.0 was used. Calculation of statistical analysis like mean and standard deviation and analysis between variations was done using student t-tests, and the association between variables was determined using Chi-square. A value was found significant when the p-value was less than 0.05. Many practitioners have been using nanoparticles prepared by using nanobiotechnology for the last 2-4 years. 92.9% of participants are well conversant with nanoparticles in treating oral cancer patients, out of which 88% are willing to specify therapeutic medicaments prepared using nano-biotechnology for oral cancer patients. 94.9% of the dentists are accepting to the fact that nanomedicine can also be used in combination therapy for treating patients, and 98% stated that the use of nanotechnology for diagnosing as well as treating patients will not only be advantageous but will also be the new face of cancer management shortly. Lack of awareness, increased tobacco consumption, and late diagnosis are the prime concerns about increasing oral cancer cases and decreased prognosis. Nanoparticles having a small particulate size will be able to detect the changes on the surface and the cellular levels and inside the cells. Similarly, in the case of therapeutic use, nanoparticles are highly efficient in delivering drugs to the systemic circulation by reducing the drug’s immunogenicity by releasing the drug in an environmentally responsive dose, thus lowering the frequency of administration and systemic toxicity.
{"title":"Knowledge, Attitude and Practice of the use of Nanoparticles in the Treatment of Oral Cancer Patients","authors":"N. Mohanty, D. Mohapatra, Shakti Rath","doi":"10.2174/03666220921100058","DOIUrl":"https://doi.org/10.2174/03666220921100058","url":null,"abstract":"\u0000\u0000To determine the knowledge, attitude and practice of the use of nanoparticles amongst health care professionals for treating oral cancer patients. Also, to understand the indications and contraindications of nanoparticles in treating oral cancer patients.\u0000\u0000\u0000\u0000A descriptive cross-sectional study was executed amongst dental surgeons practising with undergraduate and post-graduate degrees. A Google questionnaire form was developed and distributed, and 102 authentic entries were short-listed. Data obtained from the study were recorded in Microsoft Excel 2007 version, and SPSS version 18.0 was used. Calculation of statistical analysis like mean and standard deviation and analysis between variations was done using student t-tests, and the association between variables was determined using Chi-square. A value was found significant when the p-value was less than 0.05.\u0000\u0000\u0000\u0000Many practitioners have been using nanoparticles prepared by using nanobiotechnology for the last 2-4 years. 92.9% of participants are well conversant with nanoparticles in treating oral cancer patients, out of which 88% are willing to specify therapeutic medicaments prepared using nano-biotechnology for oral cancer patients. 94.9% of the dentists are accepting to the fact that nanomedicine can also be used in combination therapy for treating patients, and 98% stated that the use of nanotechnology for diagnosing as well as treating patients will not only be advantageous but will also be the new face of cancer management shortly.\u0000\u0000\u0000\u0000Lack of awareness, increased tobacco consumption, and late diagnosis are the prime concerns about increasing oral cancer cases and decreased prognosis. Nanoparticles having a small particulate size will be able to detect the changes on the surface and the cellular levels and inside the cells. Similarly, in the case of therapeutic use, nanoparticles are highly efficient in delivering drugs to the systemic circulation by reducing the drug’s immunogenicity by releasing the drug in an environmentally responsive dose, thus lowering the frequency of administration and systemic toxicity.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131490955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-13DOI: 10.2174/03666220913105943
B. Mahboub, Yousef El-Hefny, Ayman Al-Fraihat, R. Persaud, A. Juratli, Faheem A Tadros, Abdul Aljassim, A. Hantzakos, B. Hoffmann, Khairullah Alabdali, Khalid Elmesallamy, M. Shkoukani, T. Mohamed, Mohamed Alrakhawy
Allergic rhinitis (AR) is a common chronic health problem in the United Arab Emirates (UAE). Achieving adequate symptom control is pivotal to successful AR management, which may be attained following a stepwise treatment algorithm. Despite the availability of several guideline recommendations for the best management of AR, morbidity remains high in patients with AR, with treatment goals being far from the reach. The objective of this consensus statement was to discuss the currently available knowledge on the treatment of AR and to provide an expert opinion on the use of MP-AzeFlu (azelastine HCl, AZE; 137 µg per spray) and INCS (fluticasone propionate, FP; 50 µg per spray) for the effective management of AR in the UAE. A consensus meet involving 13 otorhinolaryngologists and one pulmonologist was held in Dubai, UAE, to discuss the current understanding on the treatment and management of AR. The panel advised to start AR pharmacotherapy with antihistamines (AH), leukotriene receptor antagonist (LTRA), INCS or MP-AzeFlu based on the visual analogue scale (VAS) score. In mild intermittent AR (VAS score <5/10), AH or LTRA is recommended as first-line therapy. However, in case of VAS score ≥5/10 or persistent AR, and treatment failure with AHs alone, INCS or MP-AzeFlu is recommended followed by reassessment for 7 days to confirm a step-up or step-down down therapy. Patients non-responsive to therapy were advised to step-up with MP-AzeFlu. The panel advocated a combination of intranasal second-generation AH and INCS in a single device (Dymista®) as first-line therapy for the management of AR. The algorithm provided herein can be applied in most healthcare settings by following a step-up or step-down strategy based on the VAS scores for AR control in the UAE.
{"title":"An Algorithm Recommendation for Management of Allergic Rhinitis in the United Arab Emirates: A Consensus Statement from an Expert Panel","authors":"B. Mahboub, Yousef El-Hefny, Ayman Al-Fraihat, R. Persaud, A. Juratli, Faheem A Tadros, Abdul Aljassim, A. Hantzakos, B. Hoffmann, Khairullah Alabdali, Khalid Elmesallamy, M. Shkoukani, T. Mohamed, Mohamed Alrakhawy","doi":"10.2174/03666220913105943","DOIUrl":"https://doi.org/10.2174/03666220913105943","url":null,"abstract":"\u0000\u0000Allergic rhinitis (AR) is a common chronic health problem in the United Arab Emirates (UAE). Achieving adequate symptom control is pivotal to successful AR management, which may be attained following a stepwise treatment algorithm. Despite the availability of several guideline recommendations for the best management of AR, morbidity remains high in patients with AR, with treatment goals being far from the reach.\u0000\u0000\u0000\u0000The objective of this consensus statement was to discuss the currently available knowledge on the treatment of AR and to provide an expert opinion on the use of MP-AzeFlu (azelastine HCl, AZE; 137 µg per spray) and INCS (fluticasone propionate, FP; 50 µg per spray) for the effective management of AR in the UAE.\u0000\u0000\u0000\u0000A consensus meet involving 13 otorhinolaryngologists and one pulmonologist was held in Dubai, UAE, to discuss the current understanding on the treatment and management of AR.\u0000\u0000\u0000\u0000The panel advised to start AR pharmacotherapy with antihistamines (AH), leukotriene receptor antagonist (LTRA), INCS or MP-AzeFlu based on the visual analogue scale (VAS) score. In mild intermittent AR (VAS score <5/10), AH or LTRA is recommended as first-line therapy. However, in case of VAS score ≥5/10 or persistent AR, and treatment failure with AHs alone, INCS or MP-AzeFlu is recommended followed by reassessment for 7 days to confirm a step-up or step-down down therapy. Patients non-responsive to therapy were advised to step-up with MP-AzeFlu.\u0000\u0000\u0000\u0000The panel advocated a combination of intranasal second-generation AH and INCS in a single device (Dymista®) as first-line therapy for the management of AR. The algorithm provided herein can be applied in most healthcare settings by following a step-up or step-down strategy based on the VAS scores for AR control in the UAE.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"47 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114273904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-09DOI: 10.2174/03666220909092340
Dhanya Mohan, Nahla Kharraz, H. A. Al Jaghoub, Hamzeh Alsubbah, F. Alalawi, A. Alhadari
Baclofen is a centrally acting GABA B receptor agonist, widely used for the treatment of neurological diseases ranging from hiccups to multiple sclerosis. As the drug is mainly renally excreted, intoxication can rapidly develop in those patients with a reduced glomerular filtration rate. A strong index of clinical suspicion is essential to correctly diagnose the condition. We report a case series of patients with advanced kidney disease and baclofen-induced encephalopathy that settled with discontinuation of the drug and hemodialysis sessions. We report this cluster of patients with baclofen toxicity to highlight the common occurrence of neurotoxicity after its use in patients with end-stage renal disease and its resolution after cessation of the drug and hemodialysis sessions.
{"title":"Baclofen induced encephalopathy in patients with end-stage Kidney Disease – A case series","authors":"Dhanya Mohan, Nahla Kharraz, H. A. Al Jaghoub, Hamzeh Alsubbah, F. Alalawi, A. Alhadari","doi":"10.2174/03666220909092340","DOIUrl":"https://doi.org/10.2174/03666220909092340","url":null,"abstract":"\u0000\u0000Baclofen is a centrally acting GABA B receptor agonist, widely used for the treatment of neurological diseases ranging from hiccups to multiple sclerosis. As the drug is mainly renally excreted, intoxication can rapidly develop in those patients with a reduced glomerular filtration rate. A strong index of clinical suspicion is essential to correctly diagnose the condition.\u0000\u0000\u0000\u0000We report a case series of patients with advanced kidney disease and baclofen-induced encephalopathy that settled with discontinuation of the drug and hemodialysis sessions.\u0000\u0000\u0000\u0000We report this cluster of patients with baclofen toxicity to highlight the common occurrence of neurotoxicity after its use in patients with end-stage renal disease and its resolution after cessation of the drug and hemodialysis sessions.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115377866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-17DOI: 10.2174/03666220817145707
Dileep Kumar Nanik Ram, Kashif Gulzar, F. Alalawi, Maseer Ahmed, R. Manuel, A. Alhadari
Hemodialysis patients are not only prone to acquire COVID-19 infection but also more likely to suffer a higher rate of morbidity and mortality. This study aims to report the incidence and mortality rate of COVID-19 infection in our hemodialysis patients and to determine risk factors. This is an observational, retrospective study conducted in the dialysis unit of Dubai Hospital. Our target population was hemodialysis patients who tested positive for COVID infection (PCR assay of the nasopharyngeal swab) from 1st April 2020 to 31st August 2021. Our primary outcome was to study the mortality rate associated with COVID-19 infection in dialysis patients in Dubai hospital. Our secondary objectives were to study the incidence and determine risk factors for the severity of infection. Patient demographics and clinical features were collected from medical record software, i.e., EPIC. Univariate Cox regression analysis was performed to evaluate potential risk factors for mortality in our cohort. 72 out of 250 (28.8%) hemodialysis patients acquired COVID infection during the study period, the median age was 54.32 (15-93) years, and 56.94% (n=41) were male. The most common comorbid was hypertension (59.72%), while the main symptom at presentation was shortness of breath (25%). One-third of patients required a different form of oxygen therapy, and 11.11% of patients were mechanically ventilated. The mortality rate was 16.6%. High median age, ischemic heart disease, low absolute lymphocyte count, and high levels of ferritin, LDH, and procalcitonin, as well as mechanical ventilation, were statistically significant risk factors associated with mortality. The overall outcome of COVID infection in our hemodialysis patients was better compared to the hemodialysis population from other parts of the world.
{"title":"COVID-19 infection in hemodialysis patients, incidence, risk factors and mortality. Single Centre Study","authors":"Dileep Kumar Nanik Ram, Kashif Gulzar, F. Alalawi, Maseer Ahmed, R. Manuel, A. Alhadari","doi":"10.2174/03666220817145707","DOIUrl":"https://doi.org/10.2174/03666220817145707","url":null,"abstract":"\u0000\u0000Hemodialysis patients are not only prone to acquire COVID-19 infection but also more likely to suffer a higher rate of morbidity and mortality.\u0000This study aims to report the incidence and mortality rate of COVID-19 infection in our hemodialysis patients and to determine risk factors.\u0000\u0000\u0000\u0000This is an observational, retrospective study conducted in the dialysis unit of Dubai Hospital. Our target population was hemodialysis patients who\u0000tested positive for COVID infection (PCR assay of the nasopharyngeal swab) from 1st April 2020 to 31st August 2021. Our primary outcome was to\u0000study the mortality rate associated with COVID-19 infection in dialysis patients in Dubai hospital. Our secondary objectives were to study the\u0000incidence and determine risk factors for the severity of infection. Patient demographics and clinical features were collected from medical record\u0000software, i.e., EPIC. Univariate Cox regression analysis was performed to evaluate potential risk factors for mortality in our cohort.\u0000\u0000\u0000\u000072 out of 250 (28.8%) hemodialysis patients acquired COVID infection during the study period, the median age was 54.32 (15-93) years, and\u000056.94% (n=41) were male. The most common comorbid was hypertension (59.72%), while the main symptom at presentation was shortness of\u0000breath (25%). One-third of patients required a different form of oxygen therapy, and 11.11% of patients were mechanically ventilated. The\u0000mortality rate was 16.6%. High median age, ischemic heart disease, low absolute lymphocyte count, and high levels of ferritin, LDH, and\u0000procalcitonin, as well as mechanical ventilation, were statistically significant risk factors associated with mortality.\u0000\u0000\u0000\u0000The overall outcome of COVID infection in our hemodialysis patients was better compared to the hemodialysis population from other parts of the\u0000world.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122769936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-16DOI: 10.2174/03666220816103424
M. Jhancy, G. Bernhardt, S. Srinivasamurthy, Wardha Akram, Aysha Simran Haris
Pertussis seroprotection among neonates depends on maternal antibodies before receiving their first childhood acellular pertussis (DTaP) vaccination. Therefore, childbearing women need to have adequate seroprotection, either before conception or during the antenatal period, to protect their neonates from contracting neonatal pertussis. Given the global rise in neonatal pertussis incidence, there is a need to address the importance of protection against this infection by promoting booster vaccinations among female medical students as a preventive measure for their future generation. This paper addresses a part of our study on the seroprevalence of anti-PT IgG antibodies in female medical students who are more prone to acquire infections from the patients during their clinical rotations. A cross-sectional study was conducted for three months by recruiting female medical students of RAK Medical and Health Sciences University, Ras Al Khaimah, UAE. The antibody levels (IgG) of pertussis (anti-PT) in blood sera of the study population were quantitated by enzyme-linked immunoassay. A 60 – 125 IU/mL titer was considered the positive titer level (p-value <0.05 being statistically significant). Among 90 ethnically different student participants (mean age of 21 years), forty-four percent (n=40) showed detectable titers of anti-PT IgG antibodies. Whereas fourteen percent of participants (n=13) had high positive titers above 125U/mL, four percent (n=3) showed positive titers ranging from 60-125IU/mL. Two percent (n=2) were in borderline with 55 - <60IU/mL and twenty three percent (n=21) were < 55IU/mL titres. The mean ± SD of IgG titers was 42 ± 74.93 IU/mL with a range of 0-267 IU/mL Only forty-four percent had detectable titers of anti-PT IgG antibodies, among whom fourteen percent (n=13) had high positive titers indicating recent infection. The results signify a low level of seroprotection among female medical students that emphasizes the need to promote booster vaccination for the high-risk group who work in the health profession.
{"title":"Seroprevalence of pertussis antibodies and infection risk among female medical students","authors":"M. Jhancy, G. Bernhardt, S. Srinivasamurthy, Wardha Akram, Aysha Simran Haris","doi":"10.2174/03666220816103424","DOIUrl":"https://doi.org/10.2174/03666220816103424","url":null,"abstract":"\u0000\u0000Pertussis seroprotection among neonates depends on maternal antibodies before receiving their first childhood acellular pertussis (DTaP) vaccination. Therefore, childbearing women need to have adequate seroprotection, either before conception or during the antenatal period, to protect their neonates from contracting neonatal pertussis. Given the global rise in neonatal pertussis incidence, there is a need to address the importance of protection against this infection by promoting booster vaccinations among female medical students as a preventive measure for their future generation. This paper addresses a part of our study on the seroprevalence of anti-PT IgG antibodies in female medical students who are more prone to acquire infections from the patients during their clinical rotations.\u0000\u0000\u0000\u0000A cross-sectional study was conducted for three months by recruiting female medical students of RAK Medical and Health Sciences University, Ras Al Khaimah, UAE. The antibody levels (IgG) of pertussis (anti-PT) in blood sera of the study population were quantitated by enzyme-linked immunoassay. A 60 – 125 IU/mL titer was considered the positive titer level (p-value <0.05 being statistically significant).\u0000\u0000\u0000\u0000Among 90 ethnically different student participants (mean age of 21 years), forty-four percent (n=40) showed detectable titers of anti-PT IgG antibodies. Whereas fourteen percent of participants (n=13) had high positive titers above 125U/mL, four percent (n=3) showed positive titers ranging from 60-125IU/mL. Two percent (n=2) were in borderline with 55 - <60IU/mL and twenty three percent (n=21) were < 55IU/mL titres. The mean ± SD of IgG titers was 42 ± 74.93 IU/mL with a range of 0-267 IU/mL\u0000\u0000\u0000\u0000Only forty-four percent had detectable titers of anti-PT IgG antibodies, among whom fourteen percent (n=13) had high positive titers indicating recent infection. The results signify a low level of seroprotection among female medical students that emphasizes the need to promote booster vaccination for the high-risk group who work in the health profession.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115435407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：