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CHANGES OF THE MICROCIRCULATORY SKIN BED AND ORGANS ASSOCIATED WITH THE HORMONAL-BIOCHEMICAL BACKGROUND IN WISTAR RATS WHEN MODELING DIABETES MELLITUS 糖尿病模型时wistar大鼠微循环皮肤、床和器官的激素生化变化
Pub Date : 2018-03-05 DOI: 10.29235/1561-8323-2018-62-1-101-108
E. I. Kalinovskaya, L. Archakova, T. Kuznetsova, E. L. Ryzhkovskaya, T. A. Mityukova, O. E. Poluliakh, A. A. Basalai, T. V. Balashevich
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引用次数: 0
ORIGIN OF AN ELECTROMAGNETIC FIELD UNDER IONIZATION CONDITIONS OF EXPLOSION PRODUCTS 爆炸产物电离条件下电磁场的起源
Pub Date : 2018-03-05 DOI: 10.29235/1561-8323-2018-62-1-115-119
A. F. Ilyushchenko, V. Ovchinnikov
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引用次数: 1
ВЛИЯНИЕ ГИБРИДНОГО НАПОЛНЕНИЯ КОРОТКИМ СТЕКЛОВОЛОКНОМ И ТЕРМОРАСШИРЕННЫМ ГРАФИТОМ НА СТРУКТУРУ И СВОЙСТВА ПОЛИЭТИЛЕНТЕРЕФТАЛАТА 短玻璃纤维和热膨胀石墨混合作用
Pub Date : 2018-03-05 DOI: 10.29235/1561-8323-2018-62-1-120-128
Владимир Васильевич Дубровский, В. Н. Адериха, Владимир Анатольевич Шаповалов, С. С. Песецкий
The effect of short glass fibers (GFs) and thermally expanded graphite (TEG), added to polyethyleneterephtalate (PET), on mechanical, including dynamical mechanical, and rheological properties, as well as the structural features of the produced composites is studied. Compounding with the PET melt is realized by reactive extrusion using a co-rotating twin screw extruder-reactor with L / D = 40. Analyzed composites contained from 15 to 60 wt. % of GFs, and the TEG concentration was 0.5 and 3.0 wt. It is found that hybrid filling of PET results in a synergetic increase of the tensile modulus of the composites reaching the values more than 22 GPa, as well as that of the dynamic shear modulus in a wide temperature range. Adding TEG into PET/GF composites increases the degree of binder crystallinity. An effect of an anomalous decrease in the intrinsic viscosity of PET solutions and an increase in the melt flow index of the melt composites observed at higher GF concentrations is attributed to a deeper degradation of polymer.
研究了短玻璃纤维(GFs)和热膨胀石墨(TEG)对聚乙二甲酸乙二醇酯(PET)复合材料力学性能(包括动态力学性能)和流变性能以及结构特征的影响。采用L / D = 40的同向双螺杆挤出反应器,实现了与PET熔体的反应挤出。分析了GFs含量为15 ~ 60 wt. %, TEG浓度为0.5和3.0 wt的复合材料。发现PET的混杂填充导致复合材料的拉伸模量协同增加,达到22 GPa以上的值,以及在很宽的温度范围内的动剪切模量。在PET/GF复合材料中加入TEG可以提高粘结剂的结晶度。在高GF浓度下观察到的PET溶液特性粘度的异常下降和熔体复合材料熔体流动指数的增加的影响归因于聚合物的深度降解。
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引用次数: 5
ANTICANCEROGENIC ACTIVITY OF BRASSINOSTEROIDS IN LIVER TUMOR CELLS 油菜素内酯在肝肿瘤细胞中的抗癌活性
Pub Date : 2018-03-05 DOI: 10.29235/1561-8323-2018-62-1-66-72
O. V. Panibrat, P. Shabunya, S. Fatykhava, V. Zhabinskii, P. A. Kiselev
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引用次数: 3
CHERENKOV-TYPE STIMULATED EMISSION IN GRAPHENE-BASED SYSTEMS 石墨烯基系统中的切伦科夫型受激辐射
Pub Date : 2018-03-05 DOI: 10.29235/1561-8323-2018-62-1-33-40
K. Batrakov, S. Maksimenko
{"title":"CHERENKOV-TYPE STIMULATED EMISSION IN GRAPHENE-BASED SYSTEMS","authors":"K. Batrakov, S. Maksimenko","doi":"10.29235/1561-8323-2018-62-1-33-40","DOIUrl":"https://doi.org/10.29235/1561-8323-2018-62-1-33-40","url":null,"abstract":"","PeriodicalId":11227,"journal":{"name":"Doklady Akademii nauk","volume":"30 1","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85679142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RAMAN SPECTROSCOPY STUDY OF THE BONE TISSUE WITH COXARTHROSIS 关节关节病骨组织的拉曼光谱研究
Pub Date : 2018-03-05 DOI: 10.29235/1561-8323-2018-62-1-24-32
I. Parkhomenko, L. Vlasukova, F. Komarov, A. S. Kamyshan, G. A. Uryev, A. Murzich, R. Nemkaeva
{"title":"RAMAN SPECTROSCOPY STUDY OF THE BONE TISSUE WITH COXARTHROSIS","authors":"I. Parkhomenko, L. Vlasukova, F. Komarov, A. S. Kamyshan, G. A. Uryev, A. Murzich, R. Nemkaeva","doi":"10.29235/1561-8323-2018-62-1-24-32","DOIUrl":"https://doi.org/10.29235/1561-8323-2018-62-1-24-32","url":null,"abstract":"","PeriodicalId":11227,"journal":{"name":"Doklady Akademii nauk","volume":"276 1","pages":"24-32"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73249439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ГЕНЕТИЧЕСКИЙ ПОЛИМОРФИЗМ ВНУТРИКЛЕТОЧНЫХ СИГНАЛЬНЫХ ПУТЕЙ У ПАЦИЕНТОВ С НЕМЕЛКОКЛЕТОЧНЫМ РАКОМ ЛЕГКОГО 非小细胞肺癌患者的细胞内信号通路基因多态性
Pub Date : 2018-03-04 DOI: 10.29235/1561-8323-2018-62-1-78-85
А. Н. Щаюк, Э. В. Крупнова, М. Н. Шепетько, Е. П. Михаленко, Н. В. Чеботарёва, С. Ю. Дедик, А. В. Кильчевский
The key process in the pathogenesis of any malignant neoplasms, including non-small cell lung cancer (NSCLC), is the angiogenesis that is activated by two tyrosine kinase cascades (RAS/RAF/MAPK and PI3K/AKT/mTOR). The main genes controlling these pathways are EGFR, KRAS, PIK3CA and PTEN. The study analyzed the mutations in 18–21 exons of the EGFR gene, 2 exons of the KRAS gene, 9 and 20 exons of the PIK3CA gene and 7 exons of the PTEN gene in patients with NSCLC living in Belarus and their relationship with the clinical and morphological characteristics of the tumor. Our results revealed that mutations in the EGFR gene are significantly frequent more than 5 times in patients with non-small cell lung cancer than those in the control group. Classical mutations in the EGFR gene are found only in patients with lung adenocarcinoma, predominantly in women. Mutations of the KRAS gene are found only in men, and in patients with adenocarcinoma it is 3 times more likely than in patients with squamous cell lung carcinoma. There are no somatic mutations in the PIK3CA and PTEN genes in patients with NSCLC in this study.
包括非小细胞肺癌(NSCLC)在内的任何恶性肿瘤发病的关键过程是由两种酪氨酸激酶级联反应(RAS/RAF/MAPK和PI3K/AKT/mTOR)激活的血管生成。控制这些通路的主要基因是EGFR、KRAS、PIK3CA和PTEN。本研究分析了生活在白俄罗斯的NSCLC患者EGFR基因18-21外显子、KRAS基因2外显子、PIK3CA基因9外显子和20外显子、PTEN基因7外显子的突变及其与肿瘤临床和形态特征的关系。我们的研究结果显示,非小细胞肺癌患者的EGFR基因突变频率明显高于对照组的5倍以上。EGFR基因的经典突变仅在肺腺癌患者中发现,主要发生在女性中。KRAS基因突变仅在男性中发现,并且在腺癌患者中其可能性是鳞状细胞肺癌患者的3倍。本研究中未发现NSCLC患者PIK3CA和PTEN基因的体细胞突变。
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引用次数: 0
ОБ ОЦЕНКАХ ВЕЛИЧИН РЕЗУЛЬТАНТОВ ЦЕЛОЧИСЛЕННЫХ ПОЛИНОМОВ БЕЗ ОБЩИХ КОРНЕЙ
Pub Date : 2018-03-04 DOI: 10.29235/1561-8323-2018-62-1-18-23
Алексей Сергеевич Кудин
In the article we present an improvement to the lemma on the order of simultaneous zero approximation by the values of two integer polynomials without common roots from A. O. Gelfond’s monograph “Transcendental and algebraic numbers”. The lemma says that if two integer polynomials P1 and P2 of degree not exceeding n1 and n2 and of height not exceeding Qµ1 and Qµ2 respectively having no roots in common take values 1 Px Q 1( ) −τ < and 2 Px Q 2 ( ) −τ < at some transcendental point x ∈i, then min( , ) τ τ < µ + µ +δ 1 2 12 21 n n . Gelfond’s lemma and similar results have important applications to many problems of the metric theory of Diophantine approximation. One of such applications is the result due to V. Bernik (1983) on the upper bound for the Hausdorff dimension of the set of real numbers with specified order of zero approximation by the values of integer polynomials. This result along with the result of A. Baker and W. Schmidt (1970) on the lower bound of the Hausdorff dimension of the set mentioned above gives the exact formula. In order to prove the upper bound V. Bernik improved and extended Gelfond’s lemma by considering the values of polynomials of degree not exceeding n and of height not exceeding Qµ on some interval of length Q−η and obtaining a stronger inequality τ+µ+ τ+µ−η < µ +δ 2max( , 0) 2 , n τ= τ τ min( , ). 1 2 However, the need to consider the same estimates for the degree and height of the polynomials is still restrictive and limits the range of problems this result could be applied to. In our work we consider the values of polynomials of different degrees and heights on an interval and obtain a stronger estimate by using higher order derivatives, thus improving and extending Gelfond’s lemma and existing similar results. The result is obtained using the methods of the theory of transcendental numbers.
本文对A. O. Gelfond的专著《超越与代数数》中关于两个无公根整数多项式的值同时逼近零的阶的引理作了改进。引理说,如果两个整数多项式P1和P2的阶不超过n1和n2,高度不超过Qµ1和Qµ2,它们分别在公取值1 Px q1()−τ <和2 Px q2()−τ <中没有根,在某个超越点x∈i处,则min(,) τ τ <µ+µ+δ 12 12 21 n n。Gelfond引理和类似的结果在丢番图近似的度量理论的许多问题中有重要的应用。其中一个应用是V. Bernik(1983)关于由整数多项式的值近似的指定阶的实数集的Hausdorff维的上界的结果。这一结果与A. Baker和W. Schmidt(1970)关于上述集合的Hausdorff维数下界的结果一起给出了精确的公式。为了证明v的上界,Bernik通过在长度为Q−η的区间上考虑阶数不超过n且高度不超过Qµ的多项式的值,改进和推广了Gelfond引理,得到了一个更强的不等式τ+µ+ τ+µ−η <µ+ δ 2max(, 0) 2, n τ= τ τ min(,)。12然而,考虑多项式的阶和高度的相同估计的需要仍然是限制性的,并且限制了这一结果可以适用的问题的范围。本文研究了区间上不同阶高多项式的值,利用高阶导数得到了一个更强的估计,从而改进和推广了Gelfond引理和已有的类似结果。利用超越数理论的方法得到了这一结果。
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引用次数: 0
МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКАЯ ИДЕНТИФИКАЦИЯ ИНВАЗИВНОГО ВИДА – ШАКАЛА АЗИАТСКОГО (CANIS AUREUS) НА ТЕРРИТОРИИ БЕЛАРУСИ 入侵物种的分子-基因鉴定-亚洲豺狼(CANIS AUREUS)在白俄罗斯境内
Pub Date : 2018-03-04 DOI: 10.29235/1561-8323-2018-62-1-86-92
E. Kheidorova, A. Shpak, K. Homel, Vadim E. Sidorovich, Victar V. Demianchyk, Vadzim V. Prakapchuk, M. Nikiforov
An ordinary jackal (Canis aureus Linnaeus, 1758) is a mammal species of the Canidae family that has been characterized by a rapid expansion of the range in recent decades. In Belarus, the first report on the registration of the jackal appeared in 2012 and concerned an animal that was found in the southeast of the Brest region at the end of 2011. However, this finding was not scientifically confirmed at that time. The purpose of this work was to establish by means of molecular genetic methods the species affiliation of “jackal-like” individuals hunted at different times in the territory of Belarus. Molecular genetic studies conducted on the biomaterial of three animals with unclear species affiliation confirmed the fact of the first registration of the Asian jackal in the territory of Belarus in December 2011. It is given that an Asian jackal has a connection with the Balkan distribution center. The other two “jackal-like” individuals were the representatives of the species Canis lupus on the maternal line. However, it is possible that their morphological features unusual for wolves are a consequence of their hybridization with domestic dogs. This requires a further careful study based on the nuclear genome.
普通豺(Canis aureus Linnaeus, 1758年)是犬科的一种哺乳动物,其特征是近几十年来活动范围迅速扩大。在白俄罗斯,关于胡狼登记的第一份报告出现在2012年,涉及2011年底在布列斯特地区东南部发现的一种动物。然而,这一发现在当时并没有得到科学的证实。这项工作的目的是通过分子遗传学方法确定在白俄罗斯境内不同时间被猎杀的“豺狼样”个体的物种归属。对三种物种归属不明的动物的生物材料进行的分子遗传学研究证实了2011年12月在白俄罗斯境内首次登记亚洲胡狼的事实。假设一只亚洲豺狼与巴尔干的配送中心有联系。另外两个“像豺狼”的个体是母系上狼狗物种的代表。然而,它们与狼不同的形态特征可能是它们与家犬杂交的结果。这需要基于核基因组的进一步仔细研究。
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引用次数: 2
LIGAND-BINDING AND CATALYTIC PROPERTIES OF RECOMBINANT HUMAN THROMBOXANE SYNTHASE 重组人血栓素合成酶的配体结合及催化性能
Pub Date : 2018-01-01 DOI: 10.29235/1561-8323-2018-62-1-51-65
A. V. Svirid, M. Shapira, Pavel G. Shahoika, Y. Pakhadnia, A. Gilep, S. Usanov
To study the spectrum of modulators of the human thromboxane synthase activity, the interaction of recombinant protein with various low-molecular weight ligands was analyzed. It was shown that thromboxane synthase interacts with a number of fatty acids and their derivatives (potential substrates or concurrent inhibitors), being a target for nonselective inhibition by imidazole and triazole derivatives used in medical practice and agriculture. Thus, another mechanism of action of endocrine-disrupting chemicals (EDC) was established. For the first time, the reduction of heme iron of thromboxane synthase by cytochrome P450 reductase was shown. This interaction accompanied by a partial inhibitory effect on the enzyme suppresses the formation of reaction by-products 12-hydroxyheptadecatenoic acid (12-HHT) and malonic dialdehyde (MDA). It is likely that this mechanism can participate in the regulation of the enzyme activity in vivo.
为了研究人血栓素合成酶活性调节剂的谱,分析了重组蛋白与各种低分子量配体的相互作用。研究表明,血栓素合成酶与许多脂肪酸及其衍生物(潜在底物或并发抑制剂)相互作用,成为医疗实践和农业中使用的咪唑和三唑衍生物非选择性抑制的靶标。由此,内分泌干扰物(EDC)的另一种作用机制得以确立。首次证实了细胞色素P450还原酶对血栓素合成酶血红素铁的还原作用。这种相互作用伴随着对酶的部分抑制作用,抑制了反应副产物12-羟基十七烯酸(12-HHT)和丙二醛(MDA)的形成。这一机制可能参与了体内酶活性的调控。
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引用次数: 0
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Doklady Akademii nauk
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