Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100908
Paresh Chothe, Andrea Whitcher-Johnstone, Niresh Hariparsad, Diane Ramsden
{"title":"Exploring the human 3D small intestinal model (epiintestinaltm) for improved prediction of oral absorption, metabolism and complex drug-drug interactions of small molecule drugs","authors":"Paresh Chothe, Andrea Whitcher-Johnstone, Niresh Hariparsad, Diane Ramsden","doi":"10.1016/j.dmpk.2023.100908","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100908","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"55 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100976
Jokha Al-Qassabi, Shawn Tan, Aleksandra Galetin, Amin Rostami-Hodjegan, Daniel Scotcher
{"title":"Plasma protein binding in special populations: do current PBPK models correctly account for potential changes to fraction unbound?","authors":"Jokha Al-Qassabi, Shawn Tan, Aleksandra Galetin, Amin Rostami-Hodjegan, Daniel Scotcher","doi":"10.1016/j.dmpk.2023.100976","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100976","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"48 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding CYP3A4 and P-GP mediated drug-drug interactions through PBPK modeling - case example of pralsetinib","authors":"Christine Bowman, Michael Dolton, Fang Ma, Sravanthi Cheeti, Denison Kuruvilla, Rucha Sane, Nastya Kassir, Yuan Chen","doi":"10.1016/j.dmpk.2023.100969","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100969","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"50 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100934
Bin Ma, Susan Wong, Joyce Liu, Jingwei Cai, Cyrus Khojasteh, Donglu Zhang
{"title":"Biotransformation of protein degraders bavdegalutamide and XL01126 in permeabilized cryopreserved human hepatocytes","authors":"Bin Ma, Susan Wong, Joyce Liu, Jingwei Cai, Cyrus Khojasteh, Donglu Zhang","doi":"10.1016/j.dmpk.2023.100934","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100934","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"25 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100945
Ravi Visswanathan, Elaine Tseng, Loretta Cox, Julie Cianfrogna, R. Scott Obach, Rhys Jones
{"title":"Strategies for DDI risk assessment between novel oncology agents and combination generic standard of care (SOC) agents","authors":"Ravi Visswanathan, Elaine Tseng, Loretta Cox, Julie Cianfrogna, R. Scott Obach, Rhys Jones","doi":"10.1016/j.dmpk.2023.100945","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100945","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"45 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100982
Tao Xiong, Yuxi Wang, Xuan Zhang, Xiangling Wang, Hong Zhang, Weiqun Cao, Yi Tao, Liang Shen, Genfu Chen
{"title":"Establishment and characterization of an in vitro model for NTCP substrate and inhibition assessment","authors":"Tao Xiong, Yuxi Wang, Xuan Zhang, Xiangling Wang, Hong Zhang, Weiqun Cao, Yi Tao, Liang Shen, Genfu Chen","doi":"10.1016/j.dmpk.2023.100982","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100982","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"6 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100956
Colten Eberhard, Benjamin Orsburn, Namandjé Bumpus
{"title":"Tenofovir activation is diminished in the brain and liver of creatine kinase brain-type knockout mice","authors":"Colten Eberhard, Benjamin Orsburn, Namandjé Bumpus","doi":"10.1016/j.dmpk.2023.100956","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100956","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"64 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100952
Ryan A. Dick, Xiaomin Liang, Hailing Sun, Bernard P. Murray, Bill J. Smith
{"title":"Identification and characterization of erlotinib as a potent mechanism-based inactivator of human aldehyde oxidase","authors":"Ryan A. Dick, Xiaomin Liang, Hailing Sun, Bernard P. Murray, Bill J. Smith","doi":"10.1016/j.dmpk.2023.100952","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100952","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"66 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100928
Kyle Kim, Julia Cui, Haiwei Gu, Marcus Garcia, Matthew Campen, Eliseo Castillo, Aaron Romero
{"title":"Exposure to mixed microplastic particles altered the fecal microbiome and its associated predictive functional pathways in mice","authors":"Kyle Kim, Julia Cui, Haiwei Gu, Marcus Garcia, Matthew Campen, Eliseo Castillo, Aaron Romero","doi":"10.1016/j.dmpk.2023.100928","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100928","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"27 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}