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The ACA Medicaid expansions and the supply of substance use disorder treatment services in Spanish ACA 医疗补助扩展与西班牙语药物使用障碍治疗服务的供应。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-30 DOI: 10.1016/j.drugalcdep.2024.112468
Agustina Laurito , Jonathan Cantor

Background

Given persistent disparities in substance use disorder (SUD) treatment for Spanish speakers, it is important to understand whether major health policy changes may improve access to linguistically competent services. We estimate changes in the supply of SUD treatment facilities that both accept Medicaid as payment and offer services in Spanish after the Medicaid expansions under the Affordable Care Act.

Methods

We use data from the Mental Health and Addiction Treatment Tracking Repository for years 2010–2020 to calculate the number of facilities per 100 that offered both services in Spanish and accepted Medicaid as payment, facilities per 100 that accepted Medicaid as a form of payment overall, and facilities per 100 that offered Spanish language services overall. We use a difference-in-differences strategy exploiting variation in the timing of the Medicaid expansions across states, and county-level variation in the share of Spanish speaking Latinos across and within states.

Results

We find that treatment facilities that both accepted Medicaid as a form of payment and offered Spanish language services increased by roughly 2–3 per 100, on average, in counties with the highest shares of Spanish speakers compared to counties with low to medium shares. This increase may be explained by more facilities accepting Medicaid as a form of payment.

Conclusion

The Medicaid expansions under the ACA produced a modest increase in the supply of SUD treatment facilities that both accepted Medicaid as payment and provided services in Spanish in areas with highest shares of Spanish speakers.
背景:鉴于讲西班牙语的人在药物使用障碍(SUD)治疗方面长期存在差异,了解重大的医疗政策变化是否会改善语言能力服务的获取非常重要。我们估算了根据《平价医疗法案》(Affordable Care Act)扩大医疗补助(Medicaid)范围后,既接受医疗补助(Medicaid)付款又提供西班牙语服务的药物使用障碍(SUD)治疗机构供应量的变化:我们使用精神健康和成瘾治疗追踪资料库 2010-2020 年的数据,计算出每 100 家既提供西班牙语服务又接受医疗补助付款的机构数量、每 100 家接受医疗补助付款的机构数量以及每 100 家提供西班牙语服务的机构数量。我们利用各州在扩大医疗补助计划时间上的差异,以及各州之间和州内讲西班牙语的拉美裔人口比例在县一级的差异,采用了差分策略:我们发现,在讲西班牙语人口比例最高的县,同时接受医疗补助付款方式和提供西班牙语服务的治疗机构平均每 100 家增加了约 2-3 家,而在讲西班牙语人口比例处于中低水平的县则没有增加。这一增长的原因可能是有更多的医疗机构接受医疗补助作为一种支付方式:结论:根据《美国医疗补助法案》(ACA)扩大医疗补助范围后,在西班牙语使用者比例最高的地区,接受医疗补助付款并提供西班牙语服务的 SUD 治疗机构的供应量略有增加。
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引用次数: 0
Association between gender diversity and substance use experimentation in early adolescents 青少年性别多样性与尝试使用药物之间的关系。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-29 DOI: 10.1016/j.drugalcdep.2024.112473
Iris Y. Shao , Patrick Low , Shirley Sui , Christopher D. Otmar , Kyle T. Ganson , Alexander Testa , Glenn-Milo Santos , Jinbo He , Fiona C. Baker , Jason M. Nagata

Background

Gender diversity, encompassing gender identity beyond traditional binary frameworks, has been associated with substance use during adolescence. However, there is a paucity of studies that consider different dimensions of gender diversity. This study investigates associations between multiple dimensions of gender diversity and substance experimentation in early adolescents.

Methods

Data from 10,092 adolescents aged 12–13 years from the Adolescent Brain Cognitive Development (ABCD) study were used to assess the relationship between gender diversity and substance experimentation. Gender diversity was measured using multiple dimensions, including identity (transgender), felt gender (congruence between gender identity and assigned sex), gender non-contentedness (dissatisfaction with one’s gender), gender expression (adherence to gender expression norms), and place on the gender spectrum (masculine to feminine). Substance use was evaluated using self-reported lifetime and new experimentation (past year) of alcohol, nicotine, and cannabis use. Logistic regression models adjusted for sociodemographic factors were analyzed.

Results

More gender-diverse responses for felt gender, gender non-contentedness, gender expression, and gender spectrum were associated with higher odds of lifetime alcohol experimentation. More gender-diverse responses for gender identity and gender non-contentedness were associated with higher odds of new nicotine experimentation, and more gender-diverse responses for gender identity, felt gender, gender non-contentedness, and gender expression were associated with higher odds of lifetime and new cannabis experimentation.

Conclusion

Gender diversity is differentially associated with new and lifetime substance experimentation in early adolescence. Different dimensions of gender diversity may be uniquely associated with substance use behaviors, highlighting the need for targeted interventions in gender-diverse adolescents.
背景:性别多样性(包括超越传统二元框架的性别认同)与青春期药物使用有关。然而,很少有研究考虑到性别多样性的不同层面。本研究调查了早期青少年性别多样性的多个方面与药物试验之间的关联:研究使用了来自青少年大脑认知发展(ABCD)研究的 10,092 名 12-13 岁青少年的数据,以评估性别多样性与药物尝试之间的关系。性别多样性采用多个维度进行测量,包括身份(变性人)、感觉性别(性别身份与分配性别之间的一致性)、性别无倾向性(对自己的性别不满意)、性别表达(遵守性别表达规范)以及在性别光谱中的位置(从男性化到女性化)。物质使用情况通过自我报告的终生和新尝试(过去一年)使用酒精、尼古丁和大麻的情况进行评估。对调整了社会人口学因素的逻辑回归模型进行了分析:结果:对感觉到的性别、性别无倾向性、性别表达和性别谱系的性别多样性回答越多,则终生尝试饮酒的几率越高。对性别认同和性别无倾向性的性别多元化反应越多,新尝试尼古丁的几率越高;对性别认同、感觉到的性别、性别无倾向性和性别表达的性别多元化反应越多,终生尝试大麻和新尝试大麻的几率越高:结论:在青春期早期,性别多样性与新的和终生的药物尝试有着不同的关联。性别多样性的不同方面可能与药物使用行为有独特的关联,这突出表明需要对性别多样性青少年进行有针对性的干预。
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引用次数: 0
An examination of Black-White disparities in repeat nonfatal opioid overdose incidents, fatal drug overdose, and all-cause mortality in Detroit, Michigan 对密歇根州底特律市黑人和白人在重复非致命性阿片类药物过量事件、致命性药物过量和全因死亡率方面的差异进行研究。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-28 DOI: 10.1016/j.drugalcdep.2024.112488
Grant Victor , Catherine Zettner , Guijin Lee

Background

There has been an approximately 38 percent increase in overdose deaths for Black men since 2015 yet estimates vary between major metropolitan areas. It is crucial to examine local data to inform community-driven harm reduction and overdose prevention services. We used administrative data to examine the effect of demographic characteristics and repeated nonfatal opioid overdoses (NFOO) on drug-related and all-cause mortality.

Methods

Emergency medical services (EMS) data were linked to vital records to determine fatal drug overdose and all-cause mortality. Demographic measures included age, race (Black/White), and sex (male/female). Binary logistic regression modeling was used to assess the relative influence of each of these factors on the odds of a fatal drug overdose.

Results

Among decedents, 27.0 % (n=47) experienced at least one additional NFOO prior to death. After controlling demographic characteristics, the odds of a fatal drug overdose increased by 17 % for each additional NFOO. Compared to White individuals, Black individuals were 60 % less likely to experience a fatal drug overdose, despite experiencing a significantly greater number of NFOO. All-cause mortality among Black individuals was approximately double that experienced by White individuals following a nonfatal opioid overdose.

Conclusion

There is a high risk of fatal drug overdose in the two-years following a nonfatal opioid overdose, and a greater risk of repeated NFOO. Black individuals’ mortality was associated with non-overdose causes, despite being associated with experiencing a significantly greater number of nonfatal overdoses. Widespread implementation of overdose prevention and general medical care is warranted to curb NFOO and allcause mortality.
背景:自 2015 年以来,黑人男性用药过量死亡的人数增加了约 38%,但各大都市地区的估计数字各不相同。研究当地数据至关重要,以便为社区驱动的减低伤害和预防用药过量服务提供信息。我们利用行政数据研究了人口特征和重复非致命性阿片类药物过量(NFOO)对药物相关死亡率和全因死亡率的影响:方法:将紧急医疗服务(EMS)数据与生命记录联系起来,以确定致命性药物过量和全因死亡率。人口统计学指标包括年龄、种族(黑人/白人)和性别(男性/女性)。我们使用二元逻辑回归模型来评估这些因素对吸毒过量致死几率的相对影响:在死者中,27.0%(n=47)的人在死前至少经历过一次额外的NFOO。在控制人口统计学特征后,每增加一次NFOO,致命药物过量的几率就增加17%。与白人相比,尽管黑人经历的NFOO次数要多得多,但他们发生致命药物过量的几率要低60%。黑人在非致命性阿片类药物过量后的全因死亡率约为白人的两倍:结论:在非致命性阿片类药物过量吸食后的两年内,致命性药物过量吸食的风险很高,而反复发生非致命性阿片类药物过量吸食的风险更大。黑人的死亡率与非药物过量原因有关,尽管他们经历的非致命性药物过量次数要多得多。为遏制非致命性阿片类药物过量和全因死亡率,有必要广泛实施过量预防和一般医疗护理。
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引用次数: 0
Neighborhood demographics in relation to marketing and regulation-related factors among cannabis retailers in 5 US cities 美国 5 个城市大麻零售商的邻里人口统计与营销和监管相关因素的关系
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-28 DOI: 10.1016/j.drugalcdep.2024.112471
Carla J. Berg , Nina C. Schleicher , Patricia A. Cavazos-Rehg , Katelyn F. Romm , Cassidy R. LoParco , Yuxian Cui , Yan Wang , Darcey M. McCready , Rishika Chakraborty , Lisa Henriksen

Objectives

This study assessed differences in cannabis retailer practices by neighborhood sociodemographics, which can inform disparity-relevant interventions.

Methods

Multilevel multivariable logistic regressions examined retailers’ census tract demographics (percent <21 years-old; non-Hispanic White, Black, or other race, Hispanic; median household income [MHHI]) in relation to 2022 audit data regarding marketing (youth-oriented signs, health-claims, exterior ads, price specials, membership programs, delivery/pick-up) and regulatory compliance (pregnancy and health-risk warning signage, exterior minimum-age signage) among 150 randomly-selected retailers in 5 US cities/states (Denver, Colorado; Seattle, Washington; Portland, Oregon; Las Vegas, Nevada; Los Angeles, California).

Results

20.7 % had youth-oriented signage, 28.7 % health-claim signage, 27.3 % exterior ads, 75.3 % price specials, 39.3 % membership programs, 28.0 % delivery/pick-up, 72.0 % pregnancy warnings, 38.0 % health-risk warnings, and 64.0 % minimum-age signage. Retailers in tracts with higher percent <21 and non-Hispanic White had lower odds of youth-oriented signage. Higher MHHI had higher odds of health-claims; higher percent Hispanic had lower odds of health-claims. Higher MHHI had lower odds of exterior ads. Higher percent <21 had lower odds of price specials. Higher percent non-Hispanic White had higher odds of membership programs. Higher percent non-Hispanic White, other race, and Hispanic had higher odds of delivery/pick-up; higher MHHI had lower odds of delivery/pick-up. Higher percent non-Hispanic White had higher odds of pregnancy warnings. Higher percent <21 had lowers odds of health-risk warnings. Demographics were unrelated to minimum-age signage.

Conclusions

Given key findings (e.g., less regulation-related signage in racial/ethnic minority communities), cannabis retail could exacerbate disparities, underscoring the need for related regulatory and prevention efforts.
目的本研究评估了大麻零售商的经营方式在不同社区社会人口统计学方面的差异,从而为与差异相关的干预措施提供信息。方法多层次多变量逻辑回归研究了零售商人口普查区的人口统计学特征(21 岁人口比例;非西班牙裔白人、黑人或其他种族、西班牙裔;在美国 5 个城市/州(科罗拉多州丹佛市、华盛顿州西雅图市、俄勒冈州波特兰市、内华达州拉斯维加斯市、加利福尼亚州洛杉矶市)随机抽取的 150 家零售商中,结合 2022 年有关营销(面向青少年的标识、健康声明、外部广告、特价商品、会员计划、送货/取货)和合规(怀孕和健康风险警告标识、外部最低年龄标识)的审计数据,对零售商的人口统计学特征(21 岁的百分比;非西班牙裔白人、黑人或其他种族、西班牙裔;家庭收入中位数 [MHHI])进行了分析。结果20.7%的零售商有面向青少年的标识,28.7%有健康声明标识,27.3%有户外广告,75.3%有特价商品,39.3%有会员计划,28.0%有送货/取货服务,72.0%有怀孕警告,38.0%有健康风险警告,64.0%有最低年龄标识。在 21 岁及非西班牙裔白人比例较高的地区,零售商设置青少年导向标识的几率较低。马萨诸塞州住户健康指数越高,健康诉求的几率越高;西班牙裔百分比越高,健康诉求的几率越低。男性、女性和高收入人群比例越高,户外广告出现的几率越低。21 岁以上人口比例越高,价格特惠的几率越低。非西班牙裔白人百分比越高,会员计划的几率越高。非西班牙裔白人、其他种族和西班牙裔比例越高,送货/取货的几率越高;MHHI越高,送货/取货的几率越低。非西班牙裔白人百分比越高,怀孕警告的几率越高。健康风险警告几率较低的是<21%。结论鉴于主要发现(例如,在少数种族/族裔社区,与监管相关的标识较少),大麻零售可能会加剧差异,这强调了相关监管和预防工作的必要性。
{"title":"Neighborhood demographics in relation to marketing and regulation-related factors among cannabis retailers in 5 US cities","authors":"Carla J. Berg ,&nbsp;Nina C. Schleicher ,&nbsp;Patricia A. Cavazos-Rehg ,&nbsp;Katelyn F. Romm ,&nbsp;Cassidy R. LoParco ,&nbsp;Yuxian Cui ,&nbsp;Yan Wang ,&nbsp;Darcey M. McCready ,&nbsp;Rishika Chakraborty ,&nbsp;Lisa Henriksen","doi":"10.1016/j.drugalcdep.2024.112471","DOIUrl":"10.1016/j.drugalcdep.2024.112471","url":null,"abstract":"<div><h3>Objectives</h3><div>This study assessed differences in cannabis retailer practices by neighborhood sociodemographics, which can inform disparity-relevant interventions.</div></div><div><h3>Methods</h3><div>Multilevel multivariable logistic regressions examined retailers’ census tract demographics (percent &lt;21 years-old; non-Hispanic White, Black, or other race, Hispanic; median household income [MHHI]) in relation to 2022 audit data regarding marketing (youth-oriented signs, health-claims, exterior ads, price specials, membership programs, delivery/pick-up) and regulatory compliance (pregnancy and health-risk warning signage, exterior minimum-age signage) among 150 randomly-selected retailers in 5 US cities/states (Denver, Colorado; Seattle, Washington; Portland, Oregon; Las Vegas, Nevada; Los Angeles, California).</div></div><div><h3>Results</h3><div>20.7 % had youth-oriented signage, 28.7 % health-claim signage, 27.3 % exterior ads, 75.3 % price specials, 39.3 % membership programs, 28.0 % delivery/pick-up, 72.0 % pregnancy warnings, 38.0 % health-risk warnings, and 64.0 % minimum-age signage. Retailers in tracts with higher percent &lt;21 and non-Hispanic White had lower odds of youth-oriented signage. Higher MHHI had higher odds of health-claims; higher percent Hispanic had lower odds of health-claims. Higher MHHI had lower odds of exterior ads. Higher percent &lt;21 had lower odds of price specials. Higher percent non-Hispanic White had higher odds of membership programs. Higher percent non-Hispanic White, other race, and Hispanic had higher odds of delivery/pick-up; higher MHHI had lower odds of delivery/pick-up. Higher percent non-Hispanic White had higher odds of pregnancy warnings. Higher percent &lt;21 had lowers odds of health-risk warnings. Demographics were unrelated to minimum-age signage.</div></div><div><h3>Conclusions</h3><div>Given key findings (e.g., less regulation-related signage in racial/ethnic minority communities), cannabis retail could exacerbate disparities, underscoring the need for related regulatory and prevention efforts.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112471"},"PeriodicalIF":3.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An updated view on the influence of initial opioid prescription characteristics on long-term opioid use among opioid naïve patients 关于阿片类药物处方初始特征对阿片类药物新患者长期使用阿片类药物的影响的最新观点。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-24 DOI: 10.1016/j.drugalcdep.2024.112463
Allen M. Smith , Anuj Shah , Bradley C. Martin

Objectives

This retrospective cohort study provides an updated view on the association between the likelihood of long-term opioid use (LTOU) and characteristics of the initial opioid prescription (dose, opioid type) and initial opioid prescription episode (days’ supplied) among opioid-naïve patients utilizing IQVIA PharMetrics®Plus for Academics database representative of commercially insured patients in the US.

Methods

Kaplan-Meier estimates were used to determine opioid continuation likelihood at 365 days stratified by the characteristics of the initial opioid prescription and initial opioid prescription episode. Cox-proportional hazard models were estimated to determine the strength of association between initial opioid prescription characteristics and opioid continuation.

Results

A total of 578,403 cancer-free, SUD-free, opioid-naïve subjects aged ≥14 years that filled ≥1 opioid prescriptions between April 13, 2016 and April 18, 2020 were identified and categorized based on time to opioid discontinuation. After accounting for censoring, 5.05 % of persons continued opioid use for ≥365 days. Compared to a 1–2 days’ supply (DS), the likelihood of opioid discontinuation was consistently lower with higher DS [HRs (CIs): 3–4 days' supply = 0.66 (0.65–0.66); 5–7 DS = 0.41 (0.41–0.41); 8–10 DS = 0.33 (0.33–0.34); 11–14 DS = 0.30 (0.29–0.31); 15–21 DS = 0.26 (0.26–0.27); ≥22 DS = 0.17 (0.17–0.18)]. These associations between increased DS and decreased likelihood of discontinuing opioid remained consistent across different pain etiologies.

Conclusions

In this era of more conservative opioid prescribing, increases in DS remains the strongest factor associated with a higher likelihood of LTOU.
研究目的这项回顾性队列研究利用代表美国商业保险患者的 IQVIA PharMetrics®Plus for Academics 数据库,对长期使用阿片类药物(LTOU)的可能性与阿片类药物初始处方特征(剂量、阿片类药物类型)和阿片类药物初始处方发作(供应天数)之间的关系提供了最新观点:采用 Kaplan-Meier 估计值确定阿片类药物在 365 天内继续使用的可能性,并根据初始阿片类药物处方和初始阿片类药物处方发作的特征进行分层。对 Cox 比例危险模型进行估计,以确定初始阿片类药物处方特征与阿片类药物持续使用之间的关联强度:共确定了 578,403 名无癌症、无 SUD、年龄≥14 岁、在 2016 年 4 月 13 日至 2020 年 4 月 18 日期间开具过≥1 次阿片类药物处方的受试者,并根据停用阿片类药物的时间进行了分类。在考虑删减因素后,5.05% 的人继续使用阿片类药物的时间≥365 天。与 1-2 天的供应量(DS)相比,DS 越高,停止使用阿片类药物的可能性越低[HRs (CIs):3-4 天用量 = 0.66 (0.65-0.66);5-7 天用量 = 0.41 (0.41-0.41);8-10 天用量 = 0.33 (0.33-0.34);11-14 天用量 = 0.30 (0.29-0.31);15-21 天用量 = 0.26 (0.26-0.27);≥22 天用量 = 0.17 (0.17-0.18)]。在不同的疼痛病因中,DS增加与停用阿片类药物可能性降低之间的关系仍然一致:结论:在阿片类药物处方更加保守的时代,DS的增加仍然是与LTOU可能性增加相关的最强因素。
{"title":"An updated view on the influence of initial opioid prescription characteristics on long-term opioid use among opioid naïve patients","authors":"Allen M. Smith ,&nbsp;Anuj Shah ,&nbsp;Bradley C. Martin","doi":"10.1016/j.drugalcdep.2024.112463","DOIUrl":"10.1016/j.drugalcdep.2024.112463","url":null,"abstract":"<div><h3>Objectives</h3><div>This retrospective cohort study provides an updated view on the association between the likelihood of long-term opioid use (LTOU) and characteristics of the initial opioid prescription (dose, opioid type) and initial opioid prescription episode (days’ supplied) among opioid-naïve patients utilizing IQVIA PharMetrics®Plus for Academics database representative of commercially insured patients in the US.</div></div><div><h3>Methods</h3><div>Kaplan-Meier estimates were used to determine opioid continuation likelihood at 365 days stratified by the characteristics of the initial opioid prescription and initial opioid prescription episode. Cox-proportional hazard models were estimated to determine the strength of association between initial opioid prescription characteristics and opioid continuation.</div></div><div><h3>Results</h3><div>A total of 578,403 cancer-free, SUD-free, opioid-naïve subjects aged ≥14 years that filled ≥1 opioid prescriptions between April 13, 2016 and April 18, 2020 were identified and categorized based on time to opioid discontinuation. After accounting for censoring, 5.05 % of persons continued opioid use for ≥365 days. Compared to a 1–2 days’ supply (DS), the likelihood of opioid discontinuation was consistently lower with higher DS [HRs (CIs): 3–4 days' supply = 0.66 (0.65–0.66); 5–7 DS = 0.41 (0.41–0.41); 8–10 DS = 0.33 (0.33–0.34); 11–14 DS = 0.30 (0.29–0.31); 15–21 DS = 0.26 (0.26–0.27); ≥22 DS = 0.17 (0.17–0.18)]. These associations between increased DS and decreased likelihood of discontinuing opioid remained consistent across different pain etiologies.</div></div><div><h3>Conclusions</h3><div>In this era of more conservative opioid prescribing, increases in DS remains the strongest factor associated with a higher likelihood of LTOU.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112463"},"PeriodicalIF":3.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of discomfort intolerance, discomfort avoidance, and cannabis and alcohol use among persons with chronic pain receiving prescription buprenorphine for opioid use disorder 接受处方丁丙诺啡治疗阿片类药物使用障碍的慢性疼痛患者的不适不耐受、不适回避与大麻和酒精使用的关联。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-24 DOI: 10.1016/j.drugalcdep.2024.112472
Danielle F. Haley , Michael D. Stein , Sally Bendiks , Skylar Karzhevsky , Claire Pierce , Ana Dunn , Debra S. Herman , Bradley Anderson , Risa B. Weisberg

Background

Chronic pain and non-prescribed substance use are associated with lower retention in opioid use disorder (OUD) treatment. We examined the associations of perceived capacity to tolerate uncomfortable physical sensations (discomfort intolerance and discomfort avoidance) and cannabis and alcohol use among persons with chronic pain receiving prescription buprenorphine for OUD.

Methods

This study utilizes baseline data from 163 persons with chronic pain receiving prescription buprenorphine for OUD enrolled in the Treating Opioid use, Persistent Pain, and Sadness (TOPPS) intervention trial. We used negative-binomial regression models, adjusted for age, education, gender, race/ethnicity, pain interference, depression, generalized anxiety disorder, and average cigarettes smoked/day to estimate the associations of discomfort tolerance and discomfort avoidance with frequency of cannabis and alcohol use.

Results

Participants (n=163) were on average 45 years old (standard deviation=10.6) and predominantly White (86 %, n=141). Forty-one percent (n=66) used cannabis and 24 % (n=30) used alcohol use in the past 30 days. In adjusted models, discomfort intolerance was positively associated with days of cannabis use (IRR = 1.11, p =.016) and days of alcohol use (IRR = 1.14, p =.022). Discomfort avoidance was not associated with cannabis or alcohol use.

Conclusion

Individuals with chronic pain receiving prescribed buprenorphine for treatment of OUD with lower tolerance for physical discomfort may augment pain management with cannabis and alcohol. Given the intersections between substance use and retention in care for OUD, future work should extend this preliminary work by exploring these relationships over time and in experimental settings.
Clinical Trial # NCT03698669
背景:慢性疼痛和非处方药物使用与阿片类药物使用障碍(OUD)治疗中的低保留率有关。我们研究了接受处方丁丙诺啡治疗的慢性疼痛患者对不舒服身体感觉的感知忍受能力(不适不耐和不适回避)与大麻和酒精使用的关联:本研究利用了 163 名接受处方丁丙诺啡治疗 OUD 的慢性疼痛患者的基线数据,这些患者参加了治疗阿片类药物使用、持续疼痛和悲伤(TOPPS)干预试验。我们使用负二叉回归模型,并对年龄、教育程度、性别、种族/民族、疼痛干扰、抑郁、广泛性焦虑症和平均吸烟/天数进行调整,以估计不适耐受和不适回避与大麻和酒精使用频率之间的关联:参与者(人数=163)平均年龄 45 岁(标准差=10.6),主要为白人(86%,人数=141)。在过去 30 天内,41% 的参与者(人数=66)吸食大麻,24% 的参与者(人数=30)酗酒。在调整模型中,不耐受不适感与吸食大麻天数(IRR = 1.11,p =.016)和酗酒天数(IRR = 1.14,p =.022)呈正相关。避免不适与大麻或酒精的使用无关:结论:接受丁丙诺啡处方治疗 OUD 的慢性疼痛患者对身体不适的耐受性较低,可能会使用大麻和酒精来增强疼痛控制。鉴于药物使用与 OUD 患者的保留率之间存在交叉关系,未来的工作应通过在实验环境中长期探索这些关系来扩展这项初步工作。临床试验 # NCT03698669。
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引用次数: 0
Minority stress mediates associations of sexual minority state policies and tobacco use among US sexual minority young adults 少数群体压力对美国性少数群体青壮年中性少数群体州政策与烟草使用之间的关联具有中介作用
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-23 DOI: 10.1016/j.drugalcdep.2024.112477
Katelyn F. Romm , Erin A. Vogel , Christina Dyar , Laurie A. Drabble , Patricia A. Cavazos-Rehg , Carla J. Berg

Introduction

State policies surrounding sexual minority (SM) rights are associated with tobacco use among SM individuals. Research is scant regarding the role of distinct SM policy categories on SM young adults’ (SMYAs) tobacco use and mechanisms explaining these associations.

Methods

We analyzed 2023 survey data from 1100 SMYAs (ages 18–34; 14.2 % gender minority; 66.1 % bisexual+, 29.1 % monosexual; 53.2 % racial/ethnic minority) with representation across 45 US states and DC. Regression-based models examined: 1) direct associations of residing in states with negative and limited (vs. comprehensive) SM state policies with respect to 7 policy categories (relationship/parent recognition, nondiscrimination, religious exemptions, LGBTQ youth, healthcare, criminal justice, gender identity documents) with minority stress (mental health, internalized stigma, community connectedness); 2) direct associations of policy categories and minority stress with tobacco use (past-month cigarette, e-cigarette, any tobacco use, number of products used); and 3) indirect associations of policy categories with tobacco use through minority stress.

Results

Relative to residing in states with comprehensive policies, residing in states with limited relationship/parent recognition policies indirectly predicted higher odds of e-cigarette use through mental health; weaker nondiscrimination policies indirectly predicted using more tobacco products through internalized stigma; and negative healthcare policies indirectly predicted higher odds of cigarette and any tobacco use through community connectedness.

Conclusions

These novel findings regarding associations among distinct SM policy categories, minority stress mediators, and tobacco use outcomes warrant further examination to better understand these distinct mechanisms, ultimately to inform SM-related policy and advocacy efforts, as well as tobacco prevention and cessation efforts.
导言:围绕性少数群体(SM)权利的国家政策与 SM 个人的烟草使用相关。我们分析了 2023 年 1100 名 SMYAs(18-34 岁;14.2% 为性别少数;66.1% 为双性恋+,29.1% 为单性恋;53.2% 为种族/族裔少数)的调查数据,这些调查数据来自美国 45 个州和华盛顿特区。基于回归的模型研究了1)在 7 个政策类别(关系/父母认可、不歧视、宗教豁免、LGBTQ 青年、医疗保健、刑事司法、性别认同文件)方面,居住在有消极和有限 SM 州政策(与全面 SM 州政策相比)的州与少数群体压力(心理健康、内在化污名、社区联系)的直接联系;2)政策类别和少数群体压力与烟草使用(过去一个月的香烟、电子烟、任何烟草使用、使用的产品数量)的直接联系;以及 3)政策类别通过少数群体压力与烟草使用的间接联系。结果与居住在政策全面的州相比,居住在关系/父母认可政策有限的州可通过心理健康间接预测较高的电子烟使用率;较弱的非歧视政策可通过内化污名间接预测较多的烟草制品使用率;消极的医疗保健政策可通过社区联系间接预测较高的香烟和任何烟草使用率。结论这些关于不同的 SM 政策类别、少数群体压力介导因素和烟草使用结果之间关联的新发现值得进一步研究,以更好地了解这些不同的机制,最终为 SM 相关政策和倡导工作以及烟草预防和戒烟工作提供信息。
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引用次数: 0
Does sex moderate the effects of early life stress on peripheral inflammation in alcohol use disorder? A preliminary investigation 性别会减缓早期生活压力对酒精使用障碍患者外周炎症的影响吗?初步调查
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-22 DOI: 10.1016/j.drugalcdep.2024.112474
Dylan E. Kirsch , Erica N. Grodin , Artha J. Gillis , Karen Miotto , Lara A. Ray

Introduction

Early life stress (ELS) increases risk for many medical and psychiatric illnesses, including alcohol use disorder (AUD). Females appear to be more vulnerable than males to adverse ELS-related health outcomes, including heavy alcohol use. The biological processes underlying sex differences in ELS-related drinking outcomes are not well understood. Inflammation is one biological mechanism linking ELS to adult alcohol use. This study tested whether biological sex moderates the relationship between ELS and peripheral inflammation in adults with AUD.

Methods

Treatment-seeking males (N=60) and females (N=38) with AUD completed the Adverse Childhood Experiences (ACE) questionnaire and provided blood samples for measures of peripheral C-reactive protein (CRP) and cytokines (TNF-α, IFN-γ, IL-6, IL-8, IL-10). Participants were classified as having “no/moderate-ELS” (ACE=0–3) or “high-ELS” (ACE=4+). A composite cytokine score was calculated using principal component analysis to capture general immune system activation. We tested ELS by sex interactions on CRP and cytokine levels using univariate ANOVA.

Results

The no/moderate-ELS group included 37 males and 22 females; the high-ELS group included 23 males and 16 females. There was an ELS group by sex interaction on CRP (p=0.02) and composite cytokine levels (p=0.02). Females in the high-ELS group exhibited greater CRP (p=0.003) and composite cytokine levels (p=0.01) than females in the no/moderate ELS group. There were no ELS group differences in CRP (p=0.9) or composite cytokine levels (p=0.6) in males.

Conclusion

Results suggest that sex moderates the effects of ELS on peripheral inflammation in adults with AUD; females with AUD may be more vulnerable to the ELS-related adaptations to the immune system, potentially resulting in a proinflammatory state in adulthood.
导言早期生活压力(ELS)会增加许多医疗和精神疾病的风险,包括酒精使用障碍(AUD)。与男性相比,女性似乎更容易出现与 ELS 相关的不良健康后果,包括大量饮酒。与 ELS 相关的饮酒结果的性别差异的生物学过程尚不十分清楚。炎症是将 ELS 与成人饮酒联系起来的一种生物机制。本研究测试了生理性别是否会调节 ELS 与 AUD 成人外周炎症之间的关系。方法接受治疗的 AUD 男性(60 人)和女性(38 人)填写了不良童年经历(ACE)问卷,并提供了血液样本,用于测量外周 C 反应蛋白(CRP)和细胞因子(TNF-α、IFN-γ、IL-6、IL-8、IL-10)。参与者被分为 "无/中度ELS"(ACE=0-3)或 "高ELS"(ACE=4+)。使用主成分分析法计算细胞因子的综合得分,以反映免疫系统的总体激活情况。我们使用单变量方差分析检验了 ELS 与性别对 CRP 和细胞因子水平的交互作用。结果 无/中等 ELS 组包括 37 名男性和 22 名女性;高 ELS 组包括 23 名男性和 16 名女性。在 CRP(P=0.02)和综合细胞因子水平(P=0.02)方面,ELS 组与性别之间存在交互作用。高 ELS 组女性的 CRP(p=0.003)和复合细胞因子水平(p=0.01)高于无/中度 ELS 组女性。结论结果表明,性别可调节 ELS 对 AUD 成年患者外周炎症的影响;AUD 女性患者可能更容易受到 ELS 相关免疫系统适应性的影响,从而可能导致成年后的促炎症状态。
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引用次数: 0
Correlates of post-hospitalization naltrexone adherence for alcohol use disorder 住院后坚持服用纳曲酮治疗酒精使用障碍的相关因素。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-22 DOI: 10.1016/j.drugalcdep.2024.112470
Eden Y.Bernstein , Kara M. Magane , Kimberly A. Dukes , Tibor P. Palfai , Joo H. Lee , Richard Saitz , Jeffrey H. Samet

Introduction

Hospitalizations present an opportunity to initiate naltrexone for patients with alcohol use disorder (AUD). Understanding factors associated with post-hospitalization adherence could inform practice.

Methods

This study is a secondary analysis of a clinical trial in which patients with AUD were randomized to oral (PO) versus long-acting injectable (LAI) naltrexone at hospital discharge. The outcome of this secondary analysis was naltrexone adherence 3 months after discharge, defined as receipt of at least 2 out of 3 monthly injections or the equivalent days of self-reported PO medication use (60 out of 90). We used baseline socio-demographics, substance use history, health status, healthcare utilization, and randomization arm to construct multivariable logistic regression models to identify correlates of adherence.

Results

We evaluated patients who initiated naltrexone treatment, 124 randomized to PO and 120 to LAI (overall mean age 49 years, 80 % male, 51 % Black, 47 % unhoused, and 91 % with severe AUD). At 3 months, 50 % of patients were adherent. LAI naltrexone (aOR 3.88; 95 % CI 2.17–7.13), recent office visit (aOR 2.01; 95 % CI 1.10–3.72), and age (aOR per 10-year increase 1.37; 95 % CI 1.02–1.88) were associated with increased odds of adherence. Unhoused status (aOR 0.54; 95 % CI 0.30–0.98) and cocaine use (aOR 0.35; 95 % CI 0.17–0.71) were associated with decreased odds of adherence.

Conclusions

LAI naltrexone for AUD at hospital discharge was associated with better adherence at 3 months vs PO. Access to LAI naltrexone and targeted interventions for patients with cocaine use or who are unhoused hold potential to improve naltrexone adherence.
简介:住院为酒精使用障碍(AUD)患者提供了开始使用纳曲酮的机会。了解与住院后依从性相关的因素可为实践提供参考:本研究是对一项临床试验进行的二次分析,在该试验中,AUD 患者在出院时随机接受口服 (PO) 和长效注射 (LAI) 纳曲酮治疗。这项二次分析的结果是出院 3 个月后的纳曲酮依从性,即每月 3 次注射中至少接受 2 次注射,或自我报告的口服药物使用天数达到同等水平(90 天中的 60 天)。我们利用基线社会人口统计学、药物使用史、健康状况、医疗保健使用情况和随机分组构建了多变量逻辑回归模型,以确定依从性的相关因素:我们对开始接受纳曲酮治疗的患者进行了评估,其中124人随机接受了PO治疗,120人接受了LAI治疗(总平均年龄为49岁,80%为男性,51%为黑人,47%无住房,91%患有严重的AUD)。3 个月后,50% 的患者坚持治疗。LAI 纳曲酮(aOR 3.88;95 % CI 2.17-7.13)、近期就诊(aOR 2.01;95 % CI 1.10-3.72)和年龄(aOR 每 10 年增加 1.37;95 % CI 1.02-1.88)与坚持治疗的几率增加有关。未居住状态(aOR 0.54;95 % CI 0.30-0.98)和可卡因使用(aOR 0.35;95 % CI 0.17-0.71)与坚持治疗的几率下降有关:结论:出院时接受 LAI 纳曲酮治疗 AUD 与服用 PO 相比,3 个月的依从性更好。对使用可卡因或无家可归的患者提供 LAI 纳曲酮和有针对性的干预措施有望提高纳曲酮的依从性。
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引用次数: 0
Use of tobacco price-minimization strategies among public housing residents compared to U.S. low-income adults 与美国低收入成年人相比,公共住房居民使用烟草价格最小化策略的情况。
IF 3.9 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-22 DOI: 10.1016/j.drugalcdep.2024.112476
Craig T. Dearfield , Kasra Zarei , Kelvin Choi , Debra H. Bernat

Background

Price minimization strategies (PMS) are ways for people to save money on tobacco purchases especially among those of lower socioeconomic status. This study assesses PMS and coupon receipt among public housing residents compared to U.S. low-income adults.

Methods

Data were from adults who currently use tobacco and live in District of Columbia Housing Authority (DCHA) public housing (n=270) and a US nationally representative sample of low-income adults who currently use tobacco (n=820). We examined the prevalence of PMS use across demographic characteristics and smoking behaviors, and qualitatively compared them across the two datasets.

Results

Most DCHA resident participants (84.2 %) and US low-income adults who currently use tobacco (91.5 %) recently used at least one PMS to save money on tobacco. The top-three most common strategies among DCHA residents were saving cigarettes to finish later (35.6 %), smoking fewer cigarettes (32.2 %), and finding cheaper places to buy cigarettes (30.4 %), while among U.S. low-income adults these strategies were using coupons or promotions (62.7 %), purchasing by bulk (55.5 %), and finding cheaper places to buy tobacco products (53.6 %). People who lightly smoke in DCHA were more likely than people who heavily smoke to use PMS in general (25.0 % vs. 13.7 %) and smoke fewer cigarettes to save money (35.8 % vs. 19.2 %). US low-income people who lightly smoke were more likely than people who heavily smoke to cut back on tobacco use (61.9 % vs. 39.8 %).

Conclusion

Most U.S. low-income individuals and DCHA residents who smoke engaged in PMS. Regulating these strategies while supporting tobacco use cessation may reduce the impact of tobacco in these populations.
背景:价格最小化策略(PMS)是人们在购买烟草时省钱的方法,尤其是在社会经济地位较低的人群中。本研究评估了与美国低收入成年人相比,公共住房居民的价格最小化策略和优惠券领取情况:数据来自目前使用烟草并居住在哥伦比亚特区住房管理局(DCHA)公共住房的成年人(人数=270),以及目前使用烟草的美国全国代表性低收入成年人样本(人数=820)。我们研究了不同人口特征和吸烟行为的 PMS 使用率,并对两个数据集进行了定性比较:大多数达卡区居民参与者(84.2%)和目前使用烟草的美国低收入成年人(91.5%)最近至少使用过一次PMS,以节省烟草开支。在大昌华府居民中,最常见的前三种策略分别是将香烟留到以后再抽完(35.6%)、减少吸烟量(32.2%)和寻找更便宜的香烟购买场所(30.4%),而在美国低收入成年人中,这些策略分别是使用优惠券或促销活动(62.7%)、批量购买(55.5%)和寻找更便宜的烟草制品购买场所(53.6%)。在大中华区,轻度吸烟者比重度吸烟者更有可能在一般情况下使用PMS(25.0%对13.7%),也更有可能为了省钱而少吸烟(35.8%对19.2%)。与大量吸烟者相比,轻度吸烟的美国低收入者更有可能减少烟草使用(61.9% 对 39.8%):结论:大多数吸烟的美国低收入者和 DCHA 居民都参与了 PMS。在支持戒烟的同时对这些策略进行规范可能会减少烟草对这些人群的影响。
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引用次数: 0
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Drug and alcohol dependence
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