Drug and alcohol dependence最新文献

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The association between cannabis and alcohol co-use and momentary subjective effects: Risks for increasingly hazardous cannabis use

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence

Pub Date : 2025-02-10 DOI: 10.1016/j.drugalcdep.2025.112595

Margaret F. Bedillion , Emily B. Ansell

Background

Co-use of cannabis and alcohol is associated with a higher prevalence of health-related, psychiatric, and psychosocial impairments. The aims of this study were to 1) examine the association between cannabis and alcohol co-use and subjective effects, 2) determine whether the time between cannabis and alcohol use is associated with subjective effects, and 3) examine whether subjective responses to co-use are associated with hazardous cannabis use over time.

Methods

Young adults who co-used cannabis and alcohol (N = 155, 55.5 % women, Mean age=21 yo) completed baseline, six-month, and twelve-month assessments of hazardous cannabis use. Co-use and subjective effects were assessed across 21 days of EMA at baseline.

Findings

Co-use was associated with greater momentary subjective intoxication, compared to cannabis- and alcohol-only, and stimulation and bad effects, compared to cannabis-only. Subjective intoxication was significantly higher for co-use within 0–90 minutes compared to cannabis-only. Subjective intoxication was significantly higher for co-use within 0–120 minutes compared to alcohol-only. Co-use within 0–30 minutes was associated with significantly greater stimulation and bad effects, compared to cannabis-only use moments. The extent to which an individual becomes more intoxicated when co-using the greater the risk the individual had for increasing hazardous cannabis use six and twelve months later.

Conclusion

Findings indicate that co-use is associated with increased intoxication, compared to cannabis or alcohol use alone, and increased stimulation and bad effects, compared to cannabis use alone. Subjective responses to co-use in a naturalistic setting are important to consider when evaluating long-term risk of cannabis use among young adults.

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引用次数: 0

Differences in barriers to specialty alcohol treatment between Latino and White adults with an alcohol use disorder 患有酒精使用障碍的拉丁裔和白人成年人在接受专业酒精治疗方面的障碍差异

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence

Pub Date : 2025-02-10 DOI: 10.1016/j.drugalcdep.2025.112594

M. Pinedo , SE Zemore , PA Gilbert , Y. Castro , R. Caetano

Background

Among individuals with an alcohol use disorder (AUD), little is known about why Latino adults are less likely to use formal alcohol treatment than their non-Hispanic White counterparts.

Objective

To investigate Latino-White differences in barriers to specialty alcohol treatment, including sex differences by race/ethnicity.

Methods

In 2021, a national sample of 1200 Latino and White adults with AUD were recruited to complete a structured online questionnaire. Alcohol treatment barriers were assessed using the 36-item Barriers to Specialty Alcohol Treatment (BSAT) scale. Differences in barriers to specialty alcohol treatment between Latino and White participants were examined using multivariable regression models.

Results

Latino (vs. White) adults had greater odds of reporting that specialty alcohol treatment was not culturally accepted (AOR): 1.43; 95 % CI: 1.29–1.59), concerns that providers might not understand their cultural background (AOR: 1.45; 95 % CI: 1.32–1.61), and that providers would not be of the same racial/ethnic or cultural background as them (AOR: 1.58; 95 % CI: 1.42–1.76) as reasons for not using treatment. Further, Latino (vs. White) adults were more likely to endorse immigration-related barriers to treatment, including concerns about disclosing sensitive information, such as their immigration status (AOR: 1.34; 95 % CI: 1.21–1.48) or that using treatment would negatively affect their own immigration status (AOR: 1.35; 95 % CI: 1.21–1.48) or the immigration status of someone in their family (AOR: 1.36; 95 % CI: 1.23–1.50). No sex differences by race/ethnicity were documented.

Conclusion

Culturally tailoring existing alcohol treatment services that incorporate immigration-related concerns may be key for encouraging Latino adults to use formal alcohol treatment services.

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引用次数: 0

Longitudinal patterns and predictors of opioid and stimulant use initiation and cessation among female sex workers living with HIV in South Africa

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence

Pub Date : 2025-02-09 DOI: 10.1016/j.drugalcdep.2025.112593

Catherine G. Schluth , Joseph G. Rosen , Mfezi Mcingana , Katherine B. Rucinski , Justin R. Knox , Carly A. Comins , Joel Steingo , Lillian Shipp , Siyanda Makama , Deliwe R. Phetlhu , Sharmistha Mishra , Harry Hausler , Stefan D. Baral , Sheree R. Schwartz

Female sex workers (FSW) are disproportionately impacted by HIV and substance use. Substance use has been linked to poor HIV treatment outcomes, necessitating exploration of substance use patterns — including polysubstance use — and predictors among FSW living with HIV. Data were obtained for 777 FSW living with HIV who were not virally suppressed and previously randomized to Siyaphambili, a trial of HIV treatment support strategies implemented through TB HIV Care in eThekwini, South Africa. FSW were asked about recent marijuana, opioid, stimulant, and hazardous alcohol use at enrollment and semi-annually for 18 months from June 2018-January 2022. We estimated incidence of substance use initiation/cessation post-enrollment and used Kaplan-Meier plots and lasagna plots to visualize trends. Cox proportional hazards models assessed baseline predictors of substance use initiation/cessation. Overall, 454 FSW (58.4 %) reported any opioid and/or stimulant use. Prior visit hazardous alcohol use (aHR: 0.20, 95 % CI 0.09–0.41) and prior-visit stimulant use (aHR: 2.80, 95 % CI 1.23–6.37) were negatively and positively associated with opioid initiation, respectively. Prior visit marijuana use (aHR: 1.75, 95 % CI 1.11–2.75) and opioid use (aHR: 5.31, 95 % CI 3.32–8.51) were positively associated with stimulant initiation. We found a high prevalence of substance use among FSW living with HIV that was dynamic over time, including a shared relationship between opioid and stimulant use that suggests intertwined substance use. Further investigation into the impact of polysubstance use patterns on success of HIV support strategies is needed to inform HIV treatment and harm reduction programming.

{"title":"Longitudinal patterns and predictors of opioid and stimulant use initiation and cessation among female sex workers living with HIV in South Africa","authors":"Catherine G. Schluth , Joseph G. Rosen , Mfezi Mcingana , Katherine B. Rucinski , Justin R. Knox , Carly A. Comins , Joel Steingo , Lillian Shipp , Siyanda Makama , Deliwe R. Phetlhu , Sharmistha Mishra , Harry Hausler , Stefan D. Baral , Sheree R. Schwartz","doi":"10.1016/j.drugalcdep.2025.112593","DOIUrl":"10.1016/j.drugalcdep.2025.112593","url":null,"abstract":"<div><div>Female sex workers (FSW) are disproportionately impacted by HIV and substance use. Substance use has been linked to poor HIV treatment outcomes, necessitating exploration of substance use patterns — including polysubstance use — and predictors among FSW living with HIV. Data were obtained for 777 FSW living with HIV who were not virally suppressed and previously randomized to <em>Siyaphambili</em>, a trial of HIV treatment support strategies implemented through TB HIV Care in eThekwini, South Africa. FSW were asked about recent marijuana, opioid, stimulant, and hazardous alcohol use at enrollment and semi-annually for 18 months from June 2018-January 2022. We estimated incidence of substance use initiation/cessation post-enrollment and used Kaplan-Meier plots and lasagna plots to visualize trends. Cox proportional hazards models assessed baseline predictors of substance use initiation/cessation. Overall, 454 FSW (58.4 %) reported any opioid and/or stimulant use. Prior visit hazardous alcohol use (aHR: 0.20, 95 % CI 0.09–0.41) and prior-visit stimulant use (aHR: 2.80, 95 % CI 1.23–6.37) were negatively and positively associated with opioid initiation, respectively. Prior visit marijuana use (aHR: 1.75, 95 % CI 1.11–2.75) and opioid use (aHR: 5.31, 95 % CI 3.32–8.51) were positively associated with stimulant initiation. We found a high prevalence of substance use among FSW living with HIV that was dynamic over time, including a shared relationship between opioid and stimulant use that suggests intertwined substance use. Further investigation into the impact of polysubstance use patterns on success of HIV support strategies is needed to inform HIV treatment and harm reduction programming.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"269 ","pages":"Article 112593"},"PeriodicalIF":3.9,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Infective Endocarditis and Serious Injection Related Infections Among People Who Inject Drugs in Los Angeles, CA and Denver, CO

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence

Pub Date : 2025-02-06 DOI: 10.1016/j.drugalcdep.2025.112588

Siddhi S. Ganesh , Jesse Lloyd Goldshear , Patricia Wilkins , Eric Kovalsky , Kelsey A. Simpson , Cheyenne J. Page , Karen Corsi , Rachel Carmen Ceasar , Joshua A. Barocas , Ricky N. Bluthenthal

Background

Injection drug use-related infective endocarditis (IDU-IE) and bacterial infections have grown in the United States, but little is known about risk factors for these infections in community samples of people who inject drugs (PWID).

Methods

During 2021–22, PWID were recruited from community settings and surveyed for history of IDU-IE, serious injection related symptoms (SIRI) and untreated infection symptoms in the last 3 months. We used bivariate analysis and multiple logistic regression to examine factors associated with these outcomes.

Results

Among participants (n = 472), 7 % reported ever having IDU-IE, 14 % reported having SIRI symptoms and 20 % reported untreated infection symptoms in the last 3 months. Ever having IDU-IE was associated with HCV (adjusted odds ratio [AOR]=8.37; 95 % confidence interval [CI]=2.46, 28.49), prior MRSA infection (AOR=5.37; 95 % CI=2.44, 11.80), identifying as female and/or gender minority person (AOR=3.14; 95 % CI=1.42, 6.95). SIRI symptoms were associated with greater material hardship (compared to low; AOR=2.47; 95 % CI=1.17, 5.22), fentanyl use (AOR=2.15; 95 % CI=1.01, 4.61), sharing filter/cotton (AOR=1.93; 95 % CI=1.10, 3.39), and licking needle prior to injection (AOR=1.85; 95 % CI=1.02, 3.36). Untreated infection symptoms were associated with poor quality sleep (AOR=2.04; 95 % CI=1.21, 3.43), any mental health diagnoses (AOR=2.01; 95 % CI=3.56), any chronic pain (AOR=1.89; 95 % CI=1.14, 3.11), sharing filters (AOR=1.81; 95 % CI=1.10, 2.98), and prior MRSA infection (AOR=1.75; 95 % CI=1.04, 2.97).

Conclusion

Risk factors identified include treatable co-morbidities (i.e., HCV & MRSA history, mental health, pain, opioid use), modifiable health behaviors (i.e., equipment sharing, needle-licking), and addressable structural conditions (material hardship, housing).

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引用次数: 0

Metal exposures among Native Americans who inject methamphetamine

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence

Pub Date : 2025-02-05 DOI: 10.1016/j.drugalcdep.2025.112587

Michael Anastario , Aaron Specht , Andrea Suarez , Paula Firemoon , Courtney Roper

Background

Methamphetamine injection is associated with disease outcomes that may be amplified by environmental toxicants such as metals contaminating methamphetamine preparations. This study evaluates how exposure to metals and Pb accumulation vary relative to filtration practices among Indigenous people who inject methamphetamine.

Methods

A cross-sectional survey of 100 Fort Peck Tribal members (60 people who inject methamphetamine, 40 referents) was conducted. Questionnaires were administered, and portable x-ray fluorescence measured Pb in tibial bones, metals in used syringes, and seized methamphetamine.

Results

Mean tibial bone Pb concentration did not vary between referents (13.1 μg/g, 95 % CI: 11.2–14.9) and people who inject methamphetamine (12.1 μg/g, 95 % CI: 10.9–13.3), but an interaction effect suggests that years of injection methamphetamine use across the lifespan is positively associated with tibial bone Pb concentration when filtration methods were not reported. In used syringes, Copper (Cu), Zinc (Zn), Tungsten (W), Nickel (Ni), and Mercury (Hg) mercury were detected. Participants who filtered their injection preparation had a lower mean number of metals detected in their syringes (0.19, 95 % CI: −0.06–0.45) compared to non-filterers (0.65, 95 % CI: 0.22–1.08). Zn and Ni were detected in seized methamphetamine samples provided by local law enforcement.

Conclusions

Significant variation in metals was detected between filterers and nonfilterers. More research on optimizing filtration techniques to remove metals is warranted.

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引用次数: 0

Interprofessional Perspectives on Caring for Hospitalized Patients With Opioid Use Disorder

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence

Pub Date : 2025-02-01 DOI: 10.1016/j.drugalcdep.2024.111517

Margaret Lowenstein * , M Holliday-Davis , Lilah Lesniak , David Mandell , Judy Shea

引用次数: 0

Informing the Development of Interventions for E-Cigarette Use and Smoking Risk in Young Adults

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence

Pub Date : 2025-02-01 DOI: 10.1016/j.drugalcdep.2024.111483

Denise Tran * , Jordan Davis , Colin Ring , Keegan Buch , Eric Pedersen

引用次数: 0

Analysis of Medical Claims Made on Popular E-Commerce Cannabis Platforms: Data Mining and Content Analysis of Leafly and Weedmaps

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence

Pub Date : 2025-02-01 DOI: 10.1016/j.drugalcdep.2024.111475

Matthew Nali , Zhuoran Li , Jiawei Li , Meng Zhen Larsen , Doug Roehler , Brooke Hoots , Tim Mackey

引用次数: 0

The System Isn’t Broken; How do we fix it? The Need for Workplace Education About Harm Reduction

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence

Pub Date : 2025-02-01 DOI: 10.1016/j.drugalcdep.2024.111509

Nithya Narayanan * , Miryam Baied , Debbie Humphries , Katie Wang , Phillip Marotta , Robert Heimer

引用次数: 0

Association between Cannabis Use Frequency and Total Body Water Among Young Black Adults

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence

Pub Date : 2025-02-01 DOI: 10.1016/j.drugalcdep.2024.111459

Larry Keen *

引用次数: 0

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